Preparation process and device of benzethonium chloride composition for sterilization
Through specific process flow and equipment, the problem of difficult mixing of benzethonium chloride composition components is solved, achieving uniform mixing of ingredients and improving product stability.
Patent Information
- Application Number
- CN202510465620.0
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-15
- Publication Date
- 2025-05-30
AI Technical Summary
In the existing benzethonium chloride composition preparation process, the ingredients are difficult to mix fully, resulting in inconsistent proportions of components in different parts of the product, affecting stability and reliability.
A specific process flow and device is adopted, including the use of agitating tank assembly, auxiliary assembly and distillation assembly, to ensure uniform mixing of each component through steps such as stirring, heating, layering and distillation.
The uniform mixing of benzethonium chloride composition components is achieved, the problem of local concentration inconsistent is avoided, and the stability and reliability of the product are improved.
Smart Images
Figure CN120054292A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of the preparation of benzethonium chloride compositions, and specifically to the preparation process and device of benzethonium chloride compositions for sterilization. Background Art
[0002] Benzethonium chloride composition refers to a disinfectant with broad-spectrum bactericidal effects. Benzethonium chloride composition is a cationic surfactant. By changing the permeability of the bacterial cytoplasmic membrane, it causes the cytoplasmic substances of the bacteria to leak out, thereby hindering the metabolism of the bacteria and playing a bactericidal role. Benzethonium chloride composition has a strong effect on Gram-positive bacteria. In addition, benzethonium chloride composition can quickly bind to proteins. At present, benzethonium chloride composition is widely used as a preservative and bactericide in many fields such as daily chemicals and medicine; Benzethonium chloride composition usually consists of multiple components, which makes it difficult for the components inside the benzethonium chloride composition to be fully mixed, resulting in inconsistent component ratios in different parts of the product. There may be a phenomenon that the concentration of the bactericidal active ingredient in some areas is too high or too low, affecting the stability and reliability of the benzethonium chloride composition. For this reason, we propose a preparation process and device for benzethonium chloride composition for sterilization. Summary of the Invention
[0003] The purpose of the present invention is to provide a preparation process and device for benzethonium chloride composition for sterilization to solve the problems raised in the above background art.
[0004] To solve the above technical problems, the present invention is realized through the following technical solutions: The present invention is a preparation process and device for benzethonium chloride composition for sterilization, including the following materials: tert-octylphenol, dichloroethane, potassium hydroxide solution, and benzyl chloride; Step 1: Dissolve p-tert-octylphenol in dichloroethane, add potassium hydroxide solution as a catalyst, stir and heat to a liquid temperature of 50-90 °C, react for several hours, then let it stand for stratification. Take the organic phase layer and wash it with distilled water until the pH is neutral to obtain p-tert-octylphenoxyethyl chloride; Step 2: Mix p-tert-octylphenoxyethyl chloride with dimethylethanolamine, add sodium hydroxide solution as a catalyst, stir and heat to a liquid temperature of 120-140 °C, react for several hours, then let it stand for stratification. Take the organic phase layer and carry out vacuum distillation, collect the fractions with a boiling point above 180 °C to obtain p-tert-octylphenoxyethyldimethylaminoethyl ether; Step 3: Dissolve p-tert-octylphenoxyethyldimethylaminoethyl ether in an organic solvent, add benzyl chloride, stir and heat to a liquid temperature of 70-80 °C, react for several hours, then naturally cool to room temperature, and then carry out gradient cooling crystallization. After filtration, washing, and drying, benzethonium chloride is obtained; It includes a stirring tank assembly, and the stirring tank assembly includes two stirring tank bodies. Stirring tank covers are provided at the tops of the two stirring tank bodies, and feeding hoppers are provided at the tops of the two stirring tank covers. Stirring assemblies are provided inside the two stirring tank bodies. The stirring assembly includes a motor. The motor is arranged at the center of the top of the stirring tank cover. The bottom of the motor is fixedly connected to the top of the stirring tank cover. A first transmission shaft is provided at the center of the top of the stirring tank cover. The bottom of the first transmission shaft penetrates through the stirring tank cover and extends downward. The outer surface of the first transmission shaft is rotatably connected to the inner surface of the penetrated part of the stirring tank cover. The top of the first transmission shaft is on the same horizontal line as the output end at the bottom of the motor. The output end at the bottom of the motor is fixedly connected to the top of the first transmission shaft through a coupling. Three first connecting pieces are fixedly connected to the outer surface of the first transmission shaft. The three first connecting pieces are horizontally arrayed with the outer surface of the first transmission shaft as the center. A number of first stirring blades are fixedly connected to the outer surfaces of the three first connecting pieces. The number of first stirring blades is circumferentially arrayed with the first transmission shaft as the center. By setting the rotating first stirring blades, the materials in the stirring tank body can be mixed. By setting the first connecting pieces and the first transmission shaft, the rotation of the first stirring blades can be controlled. And by setting the motor, the rotation of the first transmission shaft can be controlled.
[0005] Further, an auxiliary assembly is provided outside the stirring assembly. The auxiliary assembly includes a toothed ring and a cross-shaped second fixing plate. The outer surface of the toothed ring is fixedly connected to the inner surface of the stirring tank cover. A cross-shaped fixing plate is provided below the cross-shaped second fixing plate. The inner surfaces at the centers of the cross-shaped fixing plate and the cross-shaped second fixing plate are both fixedly connected to the outer surface of the first transmission shaft. Four gears are rotatably connected to the top of the stirring tank cover on the side away from the first transmission shaft. The four gears are circumferentially arrayed with the first transmission shaft as the center. The four gears are all meshed with the toothed ring. The bottoms of the four gears are all fixedly connected to second transmission shafts. Two second connecting pieces are fixedly connected to the outer surface of each second transmission shaft. The two second connecting pieces are horizontally arrayed with the second transmission shaft as the center. Two second stirring blades are fixedly connected to the outer surfaces of the two second transmission shafts. The two second stirring blades are circumferentially arrayed with the second transmission shaft as the center. By setting the toothed ring, when the gears are meshed with the inside of the toothed ring, they will rotate. In this way, the rotation of the four second transmission shafts can be controlled. When the four second transmission shafts rotate, they will drive the second stirring blades to rotate through the second connecting pieces.
[0006] Furthermore, a distillation component is provided at the top of the stirring tank assembly. The distillation component includes a sealed elbow pipe. The bottom of the sealed elbow pipe is fixedly connected to the top of the stirring tank top cover on the left side. A diversion pipe is arranged inside the sealed elbow pipe. The bottom of the left side of the diversion pipe is fixedly connected to a first conical funnel. The top of the first conical funnel is fixedly connected to the bottom of the left side of the sealed elbow pipe. The right side of the diversion pipe is fixedly connected to a second conical funnel. The left side of the second conical funnel is fixedly connected to the right side of the sealed elbow pipe. The center of the right side of the second conical funnel is fixedly connected to a discharge pipe. The bottom of the right side of the discharge pipe is fixedly connected to the top of the stirring tank top cover on the right side. By providing the diversion pipe, the material to be distilled can condense into water droplets on the inner surface of the diversion pipe. By providing the first conical funnel, the distilled material inside the stirring tank body on the left side can be guided into the diversion pipe. By providing the second conical funnel, the material inside the diversion pipe can be guided into the discharge pipe.
[0007] Furthermore, an adjustment component is provided outside the stirring tank assembly. The adjustment component includes an adjustment component housing. The inner surface of the adjustment component housing is fixedly connected to the outer surfaces of both stirring tank bodies. Upper and lower left circular convex blocks are fixedly connected to the upper and lower left sides of the adjustment component housing respectively. Upper and lower right circular convex blocks are fixedly connected to the upper and lower right sides of the adjustment component housing respectively. A left condensing pipe is sleeved on the outer surface of the stirring tank body on the left side. A right condensing pipe is sleeved on the outer surface of the stirring tank body on the right side. Both the left condensing pipe and the right condensing pipe are arranged inside the adjustment component housing. The top and bottom of the left condensing pipe penetrate through the left circular convex block and extend outwards. The top and bottom of the right condensing pipe penetrate through the right circular convex block and extend outwards. By providing the left condensing pipe and the right condensing pipe, the operator can control the temperatures of the two stirring tank bodies respectively, so that the materials inside the stirring tank bodies on the left and right sides can be at the most suitable temperatures.
[0008] Furthermore, a first sealing flange is sleeved on the outer surfaces of the tops of both stirring tank bodies. The inner surface of the first sealing flange is fixedly connected to the outer surfaces of both stirring tank bodies. A second sealing flange is sleeved on the outer surfaces of the bottoms of both stirring tank top covers. The inner surface of the second sealing flange is fixedly connected to the outer surfaces of both stirring tank top covers. The top of the first sealing flange is in contact with the bottom of the second sealing flange. A number of bolt holes are provided on both the second sealing flange and the first sealing flange. The bottom of the second sealing flange is fixedly connected to the top of the first sealing flange by bolts passing through the bolt holes. By providing the first sealing flange and the second sealing flange, the tops of the two stirring tank bodies and the bottoms of the two conveying stirring tank top covers can be tightly connected together, which can prevent the stirring tank top cover from accidentally falling off from the top of the stirring tank body and ensure the stability of the operation of several components inside the stirring tank assembly.
[0009] Furthermore, discharge valves are fixedly connected to the centers of the bottoms of the two stirring tank bodies. The two discharge valves are arranged in a mirror image with the outer shell of the adjusting assembly as the center. Discharge valves are fixedly connected to the left side of the discharge valve on the left and the right side of the discharge valve on the right. By providing the discharge valves, operators can discharge the materials inside the two stirring tank bodies. By providing the discharge valves, operators can control the opening and closing of the discharge valves.
[0010] Furthermore, a plurality of support columns are fixedly connected to the bottoms of the two stirring tank bodies. The plurality of support columns are all arranged outside the discharge valves. The plurality of support columns are arranged in a circumferential array with the discharge valve as the center. By providing the plurality of support columns, support force can be provided for the two stirring tank bodies, and it is ensured that the two stirring tank bodies are always on the same horizontal line, ensuring that a plurality of components inside the two stirring tank bodies can operate stably.
[0011] Furthermore, a drain pipe is fixedly connected to the top of the center of the sealed elbow pipe, and an infusion pipe is fixedly connected to the bottom of the center of the sealed elbow pipe. A booster pump is arranged below the infusion pipe. The top of the booster pump is fixedly connected to the center of the top of the second sealing flange. The output end of the top of the booster pump is fixedly connected to the bottom of the infusion pipe. A diversion pipe is arranged inside the sealed elbow pipe. By providing the drain pipe and the infusion pipe, cold water can be injected into the sealed elbow pipe and discharged. By providing the booster pump, cold water can be pumped into the sealed elbow pipe. Through the contact between the cold water and the diversion pipe, the temperature of the diversion pipe can be reduced, accelerating the condensation speed of the materials inside the diversion pipe.
[0012] The present invention has the following beneficial effects: (1) By providing the stirring assembly in the present invention, specifically when the motor is started, the output end at the bottom of the motor will drive the first transmission shaft to rotate through the coupling. When the first transmission shaft rotates, it will drive the first connecting piece to rotate. When the first connecting piece rotates, it will drive a plurality of first stirring blades to rotate synchronously. In this way, the materials inside the stirring tank body can be mixed, so that the various components in the benzethonium chloride composition are evenly mixed, avoiding the situation of too high or too low local concentration, and ensuring the stability and reliability of the benzethonium chloride composition.
[0013] (2) By providing an auxiliary component, specifically, when the motor rotates, it drives the cruciform fixing plate and the second cruciform fixing plate to rotate together, drives a number of gears to move together, and when the gears are meshed with the toothed ring, they rotate, driving the second transmission shaft fixedly connected to the bottom to rotate. When the second transmission shaft rotates, it drives a number of second stirring blades to rotate through the second connecting piece. In this way, a number of raw materials near the inner surface of the stirring tank body can be mixed, which can assist the mixing of the stirring component and ensure the uniformity of the mixing of the raw materials.
[0014] (3) By providing an adjusting component and a distillation component, specifically, the evaporated raw materials will float upward and enter the inside of the diversion pipe from the bottom of the first conical funnel. The materials in the diversion pipe will condense into liquid water droplets in the diversion pipe and move to the right. Finally, they enter the stirring tank body on the right through the discharge pipe. In this way, the materials to be processed in the stirring tank body on the left can be distilled, and the distilled materials flow from the diversion pipe and the discharge pipe into the stirring tank body on the right, which is convenient for secondary processing of the distilled materials.
[0015] Of course, it is not necessary for any product implementing the present invention to achieve all the above-mentioned advantages simultaneously. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for describing the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.
[0017] Figure 1 It is a schematic diagram of the overall structure of the present invention; Figure 2 It is a schematic diagram of the top cover structure of the stirring tank of the present invention; Figure 3 It is a schematic diagram of the structure of the stirring tank body of the present invention; Figure 4 It is a schematic diagram of the first stirring blade of the present invention; Figure 5 It is a schematic diagram of the toothed ring structure of the present invention; Figure 6 It is a schematic diagram of the gear structure of the present invention; Figure 7 It is a schematic cross-sectional view of the housing of the adjusting component of the present invention Figure 8 It is a schematic diagram of the structure of the diversion pipe of the present invention; In the drawings, the list of components represented by each reference numeral is as follows: In the figure: 1. Stirring tank assembly; 11. Stirring tank body; 121. Stirring tank top cover; 122. Feeding hopper; 131. Sealing flange one; 132. Sealing flange two; 141. Discharge valve; 142. Discharge valve body; 15. Support column; 2. Stirring assembly; 21. Electric motor; 22. First transmission shaft; 231. First connecting piece; 232. First stirring blade; 3. Auxiliary assembly; 31. Tooth ring; 321. Cross-shaped fixing plate; 322. Second cross-shaped fixing plate; 331. Gear; 332. Second transmission shaft; 333. Second connecting piece; 334. Second stirring blade; 4. Adjusting assembly; 41. Adjusting assembly housing; 421. Left circular ring convex block; 422. Right circular ring convex block; 431. Left condensing pipe; 432. Right condensing pipe; 5. Distillation assembly; 511. Sealed elbow pipe; 512. Drain pipe; 513. Liquid infusion pipe; 521. Diversion pipe; 522. First conical funnel; 523. Second conical funnel; 53. Discharge pipe; 54. Booster pump. Detailed implementation mode
[0018] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.
[0019] Please refer to Figures 1-8 As shown, the present invention is a preparation process and device for benzethonium chloride composition for sterilization, including the following materials: p-tert-octylphenol, dichloroethane, potassium hydroxide solution and benzyl chloride; Step 1: Dissolve p-tert-octylphenol in dichloroethane, add potassium hydroxide solution as a catalyst, stir and heat to a liquid temperature of 50-90 °C, let it react for several hours and then stand for stratification. Take the organic phase layer and wash it with distilled water until the pH is neutral to obtain p-tert-octylphenoxyethyl chloride; Step 2: Mix p-tert-octylphenoxyethyl chloride with dimethylethanolamine, add sodium hydroxide solution as a catalyst, stir and heat to a liquid temperature of 120-140 °C, let it react for several hours and then stand for stratification. Take the organic phase layer and perform reduced-pressure distillation, collect the fractions with a boiling point above 180 °C to obtain p-tert-octylphenoxyethyldimethylaminoethyl ether; Step 3: Dissolve p-tert-octylphenoxyethyldimethylaminoethyl ether in an organic solvent, add benzyl chloride, stir and heat to a liquid temperature of 70-80 °C, let it react for several hours and then naturally cool to room temperature. Then perform gradient cooling crystallization, filter by suction, wash and dry to obtain benzethonium chloride; It includes a stirring tank assembly 1, and the stirring tank assembly 1 includes two stirring tank bodies 11. At the top of each of the two stirring tank bodies 11, there is a stirring tank top cover 121, and at the top of each of the two stirring tank top covers 121, there is a feed hopper 122; Inside each of the two stirring tank bodies 11, there is a stirring assembly 2. The stirring assembly 2 includes a motor 21. The motor 21 is arranged at the center of the top of the stirring tank top cover 121. The bottom of the motor 21 is fixedly connected to the top of the stirring tank top cover 121. At the center of the top of the stirring tank top cover 121, there is a first transmission shaft 22. The bottom of the first transmission shaft 22 penetrates through the stirring tank top cover 121 and extends downward. The outer surface of the first transmission shaft 22 is rotationally connected to the inner surface of the penetrated part of the stirring tank top cover 121; The top of the first transmission shaft 22 is on the same horizontal line as the output end of the bottom of the motor 21. The output end of the bottom of the motor 21 is fixedly connected to the top of the first transmission shaft 22 through a coupling. Three connecting pieces one 231 are fixedly connected to the outer surface of the first transmission shaft 22. The three connecting pieces one 231 are horizontally arrayed with the outer surface of the first transmission shaft 22 as the center. A number of first stirring blades 232 are fixedly connected to the outer surface of each of the three connecting pieces one 231. The number of first stirring blades 232 is circumferentially arrayed with the first transmission shaft 22 as the center. By setting the stirring assembly 2, specifically when the motor 21 is started, the output end of the bottom of the motor 21 will drive the first transmission shaft 22 to rotate through the coupling. When the first transmission shaft 22 rotates, it will drive the connecting pieces one 231 to rotate. When the connecting pieces one 231 rotate, they will drive a number of first stirring blades 232 to rotate together. In this way, the materials inside the stirring tank body 11 can be mixed, so that the various components in the benzethonium chloride composition are evenly mixed, avoiding the situation of too high or too low local concentration, and ensuring the stability and reliability of the benzethonium chloride composition.
[0020] An auxiliary component 3 is arranged outside the stirring component 2. The auxiliary component 3 includes a toothed ring 31 and a cross-shaped fixing plate II 322. The outer surface of the toothed ring 31 is fixedly connected to the inner surface of the top cover 121 of the stirring tank. Below the cross-shaped fixing plate II 322, there is a cross-shaped fixing plate 321. The inner surfaces at the centers of the cross-shaped fixing plate 321 and the cross-shaped fixing plate II 322 are both fixedly connected to the outer surface of the first transmission shaft 22. Four gears 331 are rotatably connected to the top of the side of the stirring tank top cover 121 away from the first transmission shaft 22. The four gears 331 are arranged in a circumferential array with the first transmission shaft 22 as the center. The four gears 331 are all meshed with the toothed ring 31. The bottoms of the four gears 331 are all fixedly connected to second transmission shafts 332. Two connecting pieces II 333 are fixedly connected to the outer surface of the second transmission shaft 332. The two connecting pieces II 333 are horizontally arranged with the second transmission shaft 332 as the center. Two stirring blades II 334 are fixedly connected to the outer surfaces of the two second transmission shafts 332. The two stirring blades II 334 are arranged in a circumferential array with the second transmission shaft 332 as the center. By arranging the auxiliary component 3, specifically, when the motor 21 rotates, it will drive the cross-shaped fixing plate 321 and the cross-shaped fixing plate II 322 to rotate together, and drive a plurality of gears 331 to move together. And when the gears 331 are meshed with the toothed ring 31, they will rotate, driving the second transmission shafts 332 fixedly connected to the bottom to rotate. When the second transmission shafts 332 rotate, they will drive a plurality of stirring blades II 334 to rotate through the connecting pieces II 333. In this way, a plurality of raw materials near the inner surface of the stirring tank body 11 can be mixed, which can assist the mixing of the stirring component 2 and ensure the uniformity of the raw material mixing.
[0021] At the top of the stirring tank assembly 1, a distillation assembly 5 is provided. The distillation assembly 5 includes a sealed elbow 511. The bottom of the sealed elbow 511 is fixedly connected to the top of the stirring tank top cover 121 on the left side. Inside the sealed elbow 511, a diversion pipe 521 is provided. At the bottom on the left side of the diversion pipe 521, a first conical funnel 522 is fixedly connected. The top of the first conical funnel 522 is fixedly connected to the bottom on the left side of the sealed elbow 511. On the right side of the diversion pipe 521, a second conical funnel 523 is fixedly connected. The left side of the second conical funnel 523 is fixedly connected to the right side of the sealed elbow 511. At the center of the right side of the second conical funnel 523, a discharge pipe 53 is fixedly connected. The bottom on the right side of the discharge pipe 53 is fixedly connected to the top of the stirring tank top cover 121 on the right side. By setting the adjustment assembly for the distillation assembly 5, specifically, the evaporated raw materials will float upward and enter the inside of the diversion pipe 521 from the bottom of the first conical funnel 522. The materials inside the diversion pipe 521 will condense into liquid water droplets in the diversion pipe 521 and move to the right. Finally, they will enter the stirring tank body 11 on the right side through the discharge pipe 53. In this way, the materials to be processed in the stirring tank body 11 on the left side can be distilled, and the distilled materials can flow into the stirring tank body 11 on the right side from the diversion pipe 521 and the discharge pipe 53, which is convenient for secondary processing of the distilled materials.
[0022] On the outer side of the stirring tank assembly 1, an adjustment assembly 4 is provided. The adjustment assembly 4 includes an adjustment assembly housing 41. The inner surface of the adjustment assembly housing 41 is fixedly connected to the outer surfaces of both stirring tank bodies 11. Above and below the left side of the adjustment assembly housing 41, left circular convex blocks 421 are fixedly connected. Above and below the right side of the adjustment assembly housing 41, right circular convex blocks 422 are fixedly connected. A left condenser pipe 431 is sleeved on the outer surface of the stirring tank body 11 on the left side, and a right condenser pipe 432 is sleeved on the outer surface of the stirring tank body 11 on the right side. Both the left condenser pipe 431 and the right condenser pipe 432 are arranged inside the adjustment assembly housing 41. The top and bottom of the left condenser pipe 431 penetrate through the left circular convex blocks 421 and extend outward, and the top and bottom of the right condenser pipe 432 penetrate through the right circular convex blocks 422 and extend outward.
[0023] On the outer surfaces of the tops of both stirring tank bodies 11, a first sealing flange 131 is sleeved. The inner surface of the first sealing flange 131 is fixedly connected to the outer surfaces of both stirring tank bodies 11. On the outer surfaces of the bottoms of both stirring tank top covers 121, a second sealing flange 132 is sleeved. The inner surface of the second sealing flange 132 is fixedly connected to the outer surfaces of both stirring tank top covers 121. The top of the first sealing flange 131 is in contact with the bottom of the second sealing flange 132. A number of bolt holes are provided on both the second sealing flange 132 and the first sealing flange 131. The bottom of the second sealing flange 132 is fixedly connected to the top of the first sealing flange 131 by bolts passing through the bolt holes.
[0024] At the center of the bottom of each of the two stirring tank bodies 11, a discharge valve 141 is fixedly connected. The two discharge valves 141 are mirror - set with the adjustment component housing 41 as the center. A discharge valve 142 is fixedly connected to the left side of the discharge valve 141 on the left and the right side of the discharge valve 141 on the right.
[0025] A number of support columns 15 are fixedly connected to the bottom of each of the two stirring tank bodies 11. The number of support columns 15 are all arranged outside the discharge valve 141, and the number of support columns 15 are arranged in a circumferential array with the discharge valve 141 as the center.
[0026] At the top of the center of the sealed elbow 511, a drain pipe 512 is fixedly connected. At the bottom of the center of the sealed elbow 511, an infusion pipe 513 is fixedly connected. Below the infusion pipe 513, a booster pump 54 is provided. The top of the booster pump 54 is fixedly connected to the center of the top of the sealing flange two 132. The output end at the top of the booster pump 54 is fixedly connected to the bottom of the infusion pipe 513. A diversion pipe 521 is arranged inside the sealed elbow 511.
[0027] During use, first, dichloroethane is put into the left stirring tank body 11 from the hopper 122 at the top of the left stirring tank top cover 121, and then p - tert - octylphenol is poured into the left stirring tank body 11 from the hopper 122. Immediately afterwards, the left condensing pipe 431 on the left is connected to a hot water source through the left circular bump 421. The left condensing pipe 431 is heated under the action of the hot water circulating inside, and through the transfer action, the inside of the left stirring tank body 11 is heated through the adjustment component housing 41. The dichloroethane and p - tert - octylphenol inside the left stirring tank body 11 are heated to a liquid temperature of 50 - 90 °C. Immediately afterwards, the motor 21 is started, so that the first transmission shaft 22 rotates. When the first transmission shaft 22 rotates, it will drive the first stirring blade 232 to rotate through the first connecting piece 231. And when the first transmission shaft 22 rotates, it will drive four gears 331 to rotate through the cross - shaped fixing plate 321 and the second cross - shaped fixing plate 322. When the gear 331 is meshed and connected with the toothed ring 31, it will rotate, and drive the second connecting piece 333 to rotate through the second transmission shaft 332 fixedly connected to the bottom, and drive the second stirring blade 334 to rotate through the rotation of the second connecting piece 333. In this way, p - tert - octylphenol and dichloroethane can be mixed, and after standing and separating, p - tert - octylphenoxyethyl chloride can be obtained. Next, dimethylethanolamine and sodium hydroxide solution are injected into the stirring tank body 11 from the left hopper 122, and then the transmission shaft 22 is started to mix with the auxiliary component 3, and then the water source of the left condenser 431 is controlled to heat the tert-octylphenoxyethyl chloride, dimethylethanolamine and sodium hydroxide solution to a liquid temperature of 120-140° C., and the reaction is allowed to stand for several hours to separate into layers; Next, the temperature of the left condenser 431 is adjusted again, so that the raw materials inside the left stirring tank body 11 reach the collection boiling point of 180°C, and the distilled materials will enter the guide pipe 521 through the conical funnel 1 522, and then the booster pump 54 is started to transport cold water into the sealed elbow 511 through the infusion pipe 513 and then discharged from the discharge pipe 512. The cold water will reduce the temperature of the guide pipe 521 and the temperature of the distilled material inside the guide pipe 521, and condense into liquid, and then flow to the right, and finally flow from the conical funnel 2 523 into the discharge pipe 53, and then enter the stirring tank body 11 on the right, so that 4-tert-octylphenoxyethyl dimethylaminoethyl ether can be obtained; Finally, the organic solvent and benzyl chloride are added into the stirring tank body 11 from the feed hopper 122 of the stirring tank body 11 on the right side, and then the temperature of the right condenser 432 is controlled to heat the material inside the stirring tank body 11 on the right side to a liquid temperature of 70-80°C, and then the stirring component 2 and the auxiliary component 3 on the right side are started to mix 4-tert-octylphenoxyethyl dimethylaminoethyl ether with the organic solvent and benzyl chloride, and then naturally cooled to room temperature after reacting for several hours, and then gradient cooling crystallization is performed, and benzethonium chloride is obtained after filtration, washing and drying.
[0028] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific implementation methods described. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.
Claims
1. A process for preparing a benzethonium chloride composition for sterilization, characterized in that: The following materials are included: p-tert-octylphenol, ethylene dichloride, potassium hydroxide solution and benzyl chloride; Wherein, the production process of the benzethonium chloride composition for sterilization comprises the following steps: Step 1: dissolve 4-tert-octylphenol in dichloroethane, add potassium hydroxide solution as a catalyst, stir and heat to a liquid temperature of 50-90°C, react for several hours and then stand to separate the layers, take the organic phase and wash it with distilled water until the pH is neutral, to obtain 4-tert-octylphenoxyethyl chloride; Step 2: Mix 4-tert-octylphenoxyethyl chloride and dimethylethanolamine, add sodium hydroxide solution as a catalyst, stir and heat to a liquid temperature of 120-140°C, react for several hours, stand and separate, take the organic phase and distill under reduced pressure, collect the fraction with a boiling point above 180°C, and obtain 4-tert-octylphenoxyethyl dimethylaminoethyl ether; Step 3: dissolve 4-tert-octylphenoxyethyl dimethylaminoethyl ether in an organic solvent, add benzyl chloride, stir and heat to a liquid temperature of 70-80°C, react for several hours and then naturally cool to room temperature, then perform gradient cooling and crystallization, filter, wash and dry to obtain benzethonium chloride.
2. A device for preparing a benzethonium chloride composition for sterilization, using the process for preparing a benzethonium chloride composition for sterilization as claimed in claim 1, characterized in that: The stirring tank assembly (1) comprises two stirring tank bodies (11), the tops of the two stirring tank bodies (11) are both provided with stirring tank top covers (121), and the tops of the two stirring tank top covers (121) are both provided with material inlet hoppers (122); A stirring assembly (2) is disposed inside each of the two stirring tank bodies (11), the stirring assembly (2) comprising a motor (21), the motor (21) being disposed at the center of the top of the stirring tank top cover (121), the bottom of the motor (21) being fixedly connected to the top of the stirring tank top cover (121), a transmission shaft (22) being disposed at the center of the top of the stirring tank top cover (121), the bottom of the transmission shaft (22) penetrating the stirring tank top cover (121) and extending downward, the outer surface of the transmission shaft (22) being rotatably connected to the inner surface of the portion where the stirring tank top cover (121) is penetrated; The top of the transmission shaft (22) and the output end of the bottom of the motor (21) are on the same horizontal line, the output end of the bottom of the motor (21) is fixedly connected to the top of the transmission shaft (22) via a coupling, the outer surface of the transmission shaft (22) is fixedly connected with three connecting members (231), the three connecting members (231) are arranged in a horizontal array with the outer surface of the transmission shaft (22) as the center, and the outer surfaces of the three connecting members (231) are fixedly connected with a plurality of stirring blades (232), and the plurality of stirring blades (232) are arranged in a circular array with the transmission shaft (22) as the center.
3. The preparation device of the benzethonium chloride composition for sterilization according to claim 2, characterized in that: An auxiliary component (3) is arranged outside the stirring component (2), and the auxiliary component (3) comprises a gear ring (31) and a second cross-shaped fixing plate (322). The outer surface of the gear ring (31) is fixedly connected to the inner surface of the stirring tank top cover (121). A cross-shaped fixing plate (321) is arranged below the second cross-shaped fixing plate (322). The inner surfaces of the cross-shaped fixing plate (321) and the center of the second cross-shaped fixing plate (322) are both fixedly connected to the outer surface of the first transmission shaft (22). The top of the stirring tank top cover (121) away from the first transmission shaft (22) is rotatably connected to four gears (331). The four gears (331) are arranged on the top of the stirring tank top cover (121) and the side away from the first transmission shaft (22). The gears (331) are arranged in a circular array with the transmission shaft (22) as the center, the four gears (331) are all meshed and connected with the gear ring (31), the bottoms of the four gears (331) are all fixedly connected with the transmission shaft (332), the outer surface of the transmission shaft (332) is fixedly connected with two connecting members (333), the two connecting members (333) are arranged in a horizontal array with the transmission shaft (332) as the center, the outer surfaces of the two transmission shafts (332) are fixedly connected with two stirring blades (334), and the two stirring blades (334) are arranged in a circular array with the transmission shaft (332) as the center.
4. The preparation device of the benzethonium chloride composition for sterilization according to claim 2, characterized in that: A distillation assembly (5) is arranged on the top of the stirring tank assembly (1), and the distillation assembly (5) comprises a sealing elbow (511), the bottom of the sealing elbow (511) is fixedly connected to the top of the stirring tank top cover (121) located on the left side, a flow guide pipe (521) is arranged inside the sealing elbow (511), a conical funnel 1 (522) is fixedly connected to the bottom of the left side of the flow guide pipe (521), the top of the conical funnel 1 (522) is fixedly connected to the bottom of the left side of the sealing elbow (511), a conical funnel 2 (523) is fixedly connected to the right side of the flow guide pipe (521), the left side of the conical funnel 2 (523) is fixedly connected to the right side of the sealing elbow (511), a discharge pipe (53) is fixedly connected at the center of the right side of the conical funnel 2 (523), and the bottom of the right side of the discharge pipe (53) is fixedly connected to the top of the stirring tank top cover (121) located on the right side.
5. The preparation device of the benzethonium chloride composition for sterilization according to claim 2, characterized in that: An adjusting component (4) is provided on the outside of the stirring tank component (1), and the adjusting component (4) comprises an adjusting component housing (41). The inner surface of the adjusting component housing (41) is fixedly connected to the outer surfaces of the two stirring tank bodies (11). The upper and lower parts of the left side of the adjusting component housing (41) are fixedly connected to left annular protrusions (421), and the upper and lower parts of the right side of the adjusting component housing (41) are fixedly connected to right annular protrusions (422). The outer surface of the stirring tank body (11) on the left side is provided with a left condenser (431), and the outer surface of the stirring tank body (11) on the right side is provided with a right condenser (432). The left condenser (431) and the right condenser (432) are both arranged inside the adjusting component housing (41). The top and bottom of the left condenser (431) penetrate the left annular protrusion (421) and extend outwardly, and the top and bottom of the right condenser (432) penetrate the right annular protrusion (422) and extend outwardly.
6. The preparation device of the benzethonium chloride composition for sterilization according to claim 2, characterized in that: The outer surfaces of the tops of the two stirring tank bodies (11) are sleeved with a sealing flange 1 (131), the inner surfaces of the sealing flange 1 (131) are fixedly connected to the outer surfaces of the two stirring tank bodies (11), the outer surfaces of the bottoms of the two stirring tank top covers (121) are sleeved with a sealing flange 2 (132), the inner surfaces of the sealing flange 2 (132) are fixedly connected to the outer surfaces of the two stirring tank top covers (121), the top of the sealing flange 1 (131) is in contact with the bottom of the sealing flange 2 (132), a plurality of bolt holes are provided on the sealing flange 2 (132) and the sealing flange 1 (131), and the bottom of the sealing flange 2 (132) is fixedly connected to the top of the sealing flange 1 (131) by bolts passing through the bolt holes.
7. The preparation device of the benzethonium chloride composition for sterilization according to claim 2, characterized in that: A discharge valve (141) is fixedly connected at the center of the bottom of the two stirring tank bodies (11); the two discharge valves (141) are arranged in a mirror image with the regulating component housing (41) as the center; the left side of the discharge valve (141) on the left and the right side of the discharge valve (141) on the right are both fixedly connected with a discharge valve (142).
8. The preparation device of the benzethonium chloride composition for sterilization according to claim 2, characterized in that: A plurality of support columns (15) are fixedly connected to the bottom of the two stirring tank bodies (11); the plurality of support columns (15) are arranged outside the discharge valve (141); and the plurality of support columns (15) are arranged in a circular array with the discharge valve (141) as the center.
9. The preparation device of the benzethonium chloride composition for sterilization according to claim 4, characterized in that: A drainage pipe (512) is fixedly connected to the top at the center of the sealed curved pipe (511), an infusion pipe (513) is fixedly connected to the bottom at the center of the sealed curved pipe (511), a booster pump (54) is arranged below the infusion pipe (513), the top of the booster pump (54) is fixedly connected to the center of the top of the second sealing flange (132), the output end of the top of the booster pump (54) is fixedly connected to the bottom of the infusion pipe (513), and a flow guide pipe (521) is arranged inside the sealed curved pipe (511).