Tablet preparation process and powder tablet press for tablet preparation

Abstract

The invention relates to the technical field of medicine preparations, in particular to a tablet preparation technology and a tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet preparation powder tablet.The tablet The suction-holding type upper die set is arranged on the side portion of the vertical frame and located above the lower die set and can be adjusted in a lifting and front-back translation mode, the conveying belt is installed on the side portion of the vertical frame and located between the suction-holding type upper die set and the lower die set and extends leftwards and rightwards, and the suction-holding type upper die set and the lower die set are used in a matched mode. The lower end of the upper pressing die head is used for sucking pressed tablet bodies and transferring the tablet bodies to the conveying belt, point positions of the upper pressing die head are evenly distributed, compared with a discharging mode of a traditional tablet press, the tablet bodies can be arranged in order in the discharging and transferring process, the tablet bodies cannot collide and rub with the adjacent tablet bodies, the adjacent material receiving plate and other components, and the tablet bodies are not prone to falling off. Therefore, the appearance quality and completeness of the tablet body can be effectively ensured.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical preparations, and particularly to a tablet preparation process and a powder tablet press for tablet preparation. Background Art

[0002] Tablets are a common dosage form, having the advantages of accurate dosage, convenient administration, and low cost. In the field of preparing crystalline drug tablets, there are obvious shortcomings in the mixing link of drugs and excipients in the traditional process. The mixing method lacks scientificity, resulting in uneven dispersion of drugs in the tablets. This problem directly hinders the dissolution process after the tablets enter the human body. According to a large amount of experimental data and clinical feedback, for some tablets prepared by traditional processes, the dissolution rate within 30 minutes is only 60%-70%, which is difficult to meet the urgent clinical need for rapid drug onset. A low dissolution rate means slow drug absorption, delayed drug efficacy, and the inability to provide effective treatment support for patients in a timely manner.

[0003] When preparing cloth drug tablets, it is necessary to use a tablet press to press the prepared powdery drug into a tablet shape. Referring to the invention patent with the authorization announcement number CN103817973B, a non-sticking powder cleaning tablet discharging device for a tablet press and its use method are disclosed. When the upper die head moves down to push out the tablet body, the excess powder cannot contact the formed tablet body. Therefore, no powder will adhere to the surface of the formed tablet body after discharging, and there is no need to perform any powder removal treatment on the tablet body subsequently, nor to be equipped with any powder removal equipment and personnel. This not only improves the utilization rate of the powder, reduces the production cost, but also improves the working environment of the operators, eliminates the occupational injuries caused by the operators absorbing dust, and can maximize the integrity rate of the tablet body.

[0004] When discharging the tablets after tablet pressing, the action of the upper hydraulic cylinder is controlled to drive the upper die head to move down, pushing out the pressed tablets from the forming die cavity and falling onto the moving tablet receiving plate below. The control system controls the reciprocating linear motion component to move the moving tablet receiving plate out from below the tablet die cavity of the tablet pressing cavity template. During the moving process, when the tablet body contacts the scraping plate installed between the two guide rail bodies, all the tablet bodies falling on the moving tablet receiving plate are scraped into the packaging bag preset at the tablet discharging port to complete the material collection.

[0005] However, when the movable splicing plate is used to receive the tablet bodies, the tablet bodies are irregularly gathered and scattered on the movable splicing plate, with a high degree of disorder, making it difficult to detect the appearance of the tablet bodies. At the same time, due to the chaotic arrangement of the tablet bodies, they cannot be directly blister packed. Subsequently, additional arranging equipment is required to arrange the tablet bodies in order for blister packing, which increases the number of steps and time consumption and is inefficient. In addition, in the process of using the scraper plate and the movable splicing plate to move relative to each other, and pushing the tablet bodies collected on the movable splicing plate into the packaging bag to complete the collection, the tablet bodies will rub against the movable splicing plate. Excessive friction will cause scratches, powder loss, wear and tear on the surface of the tablet bodies, reducing the surface integrity of the tablet bodies. Summary of the invention

[0006] The object of the present invention is to provide a tablet preparation process and a tablet preparation powder tablet press to solve the technical problems raised in the above background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions.

[0008] A tablet preparation process, the specific preparation steps are as follows:

[0009] Initial mixing: ibuprofen API and microcrystalline cellulose are put into a high-speed mixer at a mass ratio of 1:1.5-1:2, and mixed at a speed of 1000-1500 r / min for 10-15 minutes to obtain an initial mixture, wherein the active pharmaceutical ingredient is ibuprofen API;

[0010] Granulation: PVP and ethanol are prepared into a binder solution with a mass concentration of 8%-10%, and the binder solution is sprayed into the primary mixed material by spraying, and then low-temperature drying is performed at 40-50°C after spraying to obtain a powder;

[0011] Granulation: the powder is sieved through a 30-40 mesh screen to obtain fine powder;

[0012] Total mixing: adding 1%-3% of cross-linked sodium carboxymethyl cellulose and 0.5%-1% of magnesium stearate by mass ratio to the fine powder, placing the mixture in a three-dimensional mixer, and mixing the mixture at a speed of 30-50 r / min for 15-20 minutes to obtain a powder material;

[0013] Tableting: The powder material is compressed into tablets using a tablet preparation powder press, and the pressure range is controlled at 10-15 kN.

[0014] Preferably, the present invention further provides a powder tablet press for tablet preparation, which includes a vertical frame, a suction-type upper die set, a lower die set and a conveyor belt. The lower die set is arranged on the side of the vertical frame and can be adjusted vertically. The suction-type upper die set is arranged on the side of the vertical frame and above the lower die set, and can be adjusted vertically and horizontally. The conveyor belt is installed on the side of the vertical frame and between the suction-type upper die and the lower die set, and extends horizontally. The suction-type upper die set and the lower die set are used in cooperation to press the powder material into a tablet body. The suction-type upper die set includes a number of evenly distributed upper pressing die heads, and the bottom end of each upper pressing die head has a negative pressure suction effect for sucking and transferring the pressed tablet body onto the conveyor belt.

[0015] Preferably, an installation table is installed on the side of the vertical frame between the conveyor belt and the lower die set through a first cross frame. A number of vertically penetrating sliding holes are evenly distributed on the installation table, and the positions of the sliding holes correspond to the positions of the upper pressing die heads one by one. The lower die set includes a tablet pressing cylinder body, a sliding rod, a lower pressing die head, a first hydraulic cylinder and a second hydraulic cylinder. On both side surfaces of the installation table, first hydraulic cylinders with downwardly extending telescopic rods are vertically fixed through first side frames. On the end parts of the telescopic rods of the two first hydraulic cylinders, second side frames are fixed respectively. A first mounting plate is fixed between the two second side frames. A number of tablet pressing cylinder bodies corresponding to the positions of the sliding holes one by one are evenly distributed on the first mounting plate. The openings of the tablet pressing cylinder bodies are all arranged upward. A lower pressing die head is slidably installed in each tablet pressing cylinder body in a matching manner. A vertically extending sliding rod is fixed to the bottom of each lower pressing die head, and the sliding rods all slide through and extend below the tablet pressing cylinder body. On both sides of the first mounting plate, second hydraulic cylinders extending vertically are fixed respectively. The telescopic rods of the two second hydraulic cylinders both extend downward, and their end parts are jointly fixed to a second mounting plate. The sliding rods are all fixed to the second mounting plate.

[0016] Preferably, the suction-type upper die set further includes a piston rod, a plugging head, a piston body, a second power guide rail, a third liquid oxygen cylinder and a fourth liquid oxygen cylinder. The second power guide rail is installed on the side of the vertical frame. A second moving seat capable of moving back and forth is installed below the second power guide rail. An installation seat is fixed below the second moving seat. On both sides of the lower surface of the installation seat, third liquid oxygen cylinders extending vertically downward are fixed respectively. On the end parts of the telescopic rods of the two third liquid oxygen cylinders, a third mounting plate is jointly fixed. The upper pressing die heads are all fixed on the third mounting plate, and the upper pressing die heads can be inserted into the tablet pressing cylinder bodies in a one-to-one corresponding and matching manner. A piston cavity is provided in each upper pressing die head, and a suction hole communicating with the piston cavity is provided at the bottom end of each upper pressing die head. Third side frames are fixed on both side surfaces of the third mounting plate. On both third side frames, fourth liquid oxygen cylinders are vertically fixed respectively. On the end parts of the telescopic rods of the two fourth liquid oxygen cylinders, fourth side frames are fixed respectively. A fourth mounting plate is fixed between the two fourth side frames. A number of piston rods are evenly distributed and fixed below the fourth mounting plate. Each piston rod extends into the piston cavity in a sliding manner in a one-to-one corresponding manner. A plugging head that is slidably matched and installed in the suction hole is fixed to the bottom end of each piston rod. A piston body that is closely and movably attached to the inner wall of the piston cavity is fixed on the outer wall of each piston rod.

[0017] Preferably, lower die holes are provided at the top of the lower pressing die head, and the aperture of the lower die hole becomes smaller downward. Upper die holes are provided at the bottom end of the upper pressing die head, and the aperture of the upper die hole becomes larger upward. The suction holes communicate with the upper die holes. During tablet pressing, the bottom end surface of the plugging head is flush with the inner end wall of the upper die hole. When the upper pressing die head is inserted into the tablet pressing cylinder body for tablet pressing, the powder material is formed into a cavity formed between the upper die hole and the lower die hole.

[0018] Preferably, the top end of each tablet pressing cylinder body has an annular inclined slope, and the diameter of the inclined slope becomes larger downward.

[0019] Preferably, a rectangular frame body distributed around the periphery of the sliding hole is fixed on the upper surface of the installation table. One side of the rectangular frame body is side A, and the other side is side B. A second cross frame is fixed on the side surface of the vertical frame, a feeding device is fixed at the end of the second cross frame, a feeding pipe is provided below the feeding device, and the bottom end of the feeding pipe is close to side A of the rectangular frame body.

[0020] Preferably, a pair of partition plates are installed in the rectangular frame body. Both partition plates extend beyond the upper part of the rectangular frame body. The two side end faces of the two partition plates are respectively in sliding fit with the inner side wall of the rectangular frame body. The bottom ends of the two partition plates are respectively in sliding fit with the upper surface of the installation table. A storage cavity for storing powder material is formed between the two partition plates and the inner side walls on both sides of the installation table. First power guide rails are respectively installed on both sides of the rectangular frame body. Movable first moving seats are installed on both first power guide rails. Connecting walls are fixed on the tops of the two first moving seats. Side plates are respectively fixed at the two side ends of the two partition plates and above the rectangular frame body. The bottom parts of the two side plates are respectively in sliding fit with the upper end surface of the rectangular frame body. The two connecting walls are respectively fixedly connected with the corresponding side plates. When the two partition plates move to the extreme position on side A, the bottom end of the feeding pipe faces the middle of the storage cavity.

[0021] Preferably, a bidirectional threaded rod is rotatably installed between the two side plates. One end of the bidirectional threaded rod penetrates through and extends to the outside of the corresponding side plate and is fixedly sleeved with a gear. A rack parallel to the length direction of the first power guide rail is fixed on the corresponding side surface of the rectangular frame body. The rack is correspondingly meshed with the gear. A pair of scraping blades are installed between the two partition plates in a limit sliding manner. The two scraping blades are respectively sleeved on both sides of the bidirectional threaded rod through screw holes on them in a threaded matching manner. When the two partition plates move from side A to side B, the two scraping blades move away from each other. When the two partition plates move from side B to side A, the two scraping blades move closer to each other. And when the two partition plates move to the extreme position on side A, the two scraping blades are in contact and centered.

[0022] Preferably, trays are placed equidistantly on the conveyor belt. A number of placement grooves for placing tablet bodies are evenly distributed on the trays. The positions of the placement grooves correspond one by one to the positions of the upper pressing die heads.

[0023] Compared with the prior art, the beneficial effects of the present invention are as follows.

[0024] The tablet preparation powder press provided by the present invention uses the lower end of the upper pressing die head to hold the pressed tablet body and transfer it to the conveyor belt. Moreover, the position points of the upper pressing die head are evenly distributed. Compared with the discharging method of traditional tablet presses, during the discharging and transferring process of the tablet body, the tablet bodies can be arranged orderly. Furthermore, the tablet bodies will not collide or rub against adjacent tablet bodies, the receiving plate, and other components, thereby effectively ensuring the appearance quality and integrity of the tablet bodies.

[0025] When the tablet preparation powder press provided by the present invention transfers the pressed tablet bodies to the conveyor belt by the suction-type upper module, a material tray is arranged at equal intervals on the conveyor belt, and each placement groove on the material tray corresponds to the position of the upper pressing die head one by one. When the suction-type upper module descends, each tablet body can be transferred to the placement groove one by one, realizing the orderly arrangement of the tablet bodies, so as to detect and blister-pack the tablet bodies. Subsequently, there is no need to arrange the tablet bodies additionally, reducing the process and the time-consuming of the processing process, and improving the production efficiency.

[0026] Through the structural design of the lower die concave hole and the upper die concave hole, the two ends of the formed tablet body provided by the present invention are in a chamfered shape that gradually converges towards the axis, so that the contact area between the outer peripheral wall of the tablet body and the inner wall of the tablet pressing cylinder is small, and the friction during demolding is small, ensuring that the process of demolding the tablet body from the inside of the tablet pressing cylinder to the outside is more relaxed and smooth. During the blister packaging process, the tablet body with chamfered ends is more likely to accurately fall into the blister, improving the accuracy and speed of filling, and at the same time facilitating users to take out the medicine for taking.

[0027] When the powder material is supplemented into the storage cavity through the feeding pipe in the tablet preparation powder press provided by the present invention, the bottom end of the feeding pipe is arranged facing the middle of the storage cavity, so that the powder material accumulates in the middle of the storage cavity and is distributed in a state of being high in the middle and low on the periphery. When the two partition plates move, the rotation of the bidirectional threaded rod is driven by the linkage cooperation of the gear and the rack. The rotating bidirectional threaded rod drives the two scraping blades to move away from each other by threads, and the powder material in the middle can be pushed flat to both sides, ensuring that the powder material is evenly distributed in the storage cavity and avoiding the insufficient amount of powder material in the two side areas of the storage cavity and being unable to complete the filling of the tablet pressing cylinder. Secondly, during the movement of the two partition plates, the meshing transmission of the gear and the rack is used as the driving source for the rotation of the bidirectional threaded rod, and thus no additional drive needs to be set, reducing the manufacturing cost.

[0028] The tablets prepared by using the preparation process provided by the present invention have stronger stability and longer shelf life. At the same time, the quality of the tablets is ensured to be uniform, the efficacy of each tablet is more stable and reliable, and the dissolution rate of ibuprofen is significantly improved, and the efficacy can be exerted faster. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is the specific flow chart of the tablet preparation process provided by the present invention;

[0030] Figure 2 Schematic three-dimensional diagram of the overall structure of the tablet preparation powder press provided by the present invention;

[0031] Figure 3 is Figure 2 Schematic diagram of the partial structure shown;

[0032] Figure 4 is Figure 3 Enlarged schematic diagram of the structure at A in;

[0033] Figure 5 Schematic diagram of the internal structure of the tablet pressing cylinder in the present invention;

[0034] Figure 6 Schematic diagram of the installation of the upper pressing die head structure in the present invention;

[0035] Figure 7 Schematic diagram of the internal structure of the upper pressing die head in the present invention;

[0036] Figure 8 Schematic diagram of the structure above the installation table in the present invention;

[0037] Figure 9 is Figure 8 Enlarged schematic diagram of the structure at A in;

[0038] Figure 10 is Figure 8 Schematic sectional view of the structure shown;

[0039] Figure 11 Schematic diagram of the tablet body being pressed and formed;

[0040] Figure 12 Schematic diagram of the tablet body structure;

[0041] Figure 13 Schematic diagram of the piston body moving upward to hold the tablet body;

[0042] Figure 14 Schematic diagram of the feed pipe supplying the powder material between the two partitions;

[0043] Figure 15 Schematic diagram of the two partitions moving away from each other to level the powder material pile;

[0044] Figure 16 Schematic diagram of the structure of the feeding tray on the conveyor belt;

[0045] Figure 17 Schematic diagram of the powder material entering between the inclined plane and the inner wall of the sliding hole.

[0046] In the figure: 01, tablet body; 02, powder material; 1, vertical frame; 11, first horizontal frame; 12, second horizontal frame; 13, feeder; 14, feeding pipe; 2, installation table; 21, sliding hole; 3, tablet pressing cylinder body; 301, inclined slope; 31, sliding rod; 32, lower pressing die head; 321, lower die concave hole; 33, first side frame; 34, first hydraulic cylinder; 35, second side frame; 36, first mounting plate; 37, second hydraulic cylinder; 38, second mounting plate; 4, upper pressing die head; 41, upper die concave hole; 42, suction hole; 43, piston cavity; 44, piston rod; 45, plugging head; 46, piston body; 5, rectangular frame body; 51, A side; 52, B side; 6, partition board; 601, storage cavity; 61, first power guide rail; 62, first moving seat; 63, connecting wall; 64, side board; 7, scraping blade; 71, bidirectional threaded rod; 72, gear; 73, rack; 8, second power guide rail; 81, second moving seat; 82, mounting seat; 83, third liquid oxygen cylinder; 84, third mounting plate; 85, third side frame; 86, fourth liquid oxygen cylinder; 87, fourth side frame; 88, fourth mounting plate; 9, conveyor belt; 91, material tray; 92, placing groove. Specific embodiments

[0047] The embodiments of the present invention will be described below with reference to the accompanying drawings in the embodiments of the present invention.

[0048] Please refer to Figure 1 , the present invention provides a tablet preparation process, and the specific preparation steps are as follows:

[0049] Initial mixing: The ibuprofen raw material and microcrystalline cellulose are put into a high-speed mixer according to a mass ratio of 1:1.5 - 1:2, and mixed at a speed of 1000 - 1500 r / min for 10 - 15 minutes to obtain an initially mixed material. Among them, the drug active ingredient is the ibuprofen raw material.

[0050] Granulation: PVP and an appropriate amount of ethanol are formulated into a binder solution with a mass concentration of 8% - 10%, and the binder solution is sprayed into the initially mixed material by a spraying method. After spraying, low-temperature drying is carried out at 40 - 50 °C to obtain a powder material.

[0051] Screening: The powder material is screened through a 30 - 40 mesh sieve to obtain a fine powder material.

[0052] Final mixing: 1% - 3% of croscarmellose sodium and 0.5% - 1% of magnesium stearate are added to the fine powder material, and put into a three-dimensional mixer, and mixed at a speed of 30 - 50 r / min for 15 - 20 minutes to obtain a powder material.

[0053] Tablet pressing: The powder material is tablet-pressed by a tablet preparation powder press, and the pressure range is controlled at 10 - 15 kN.

[0054] Example 1

[0055] Weigh 100 g of ibuprofen API, 150 g of microcrystalline cellulose, 10 g of PVP, 100 g of ethanol, 4 g of croscarmellose sodium, and 2 g of magnesium stearate. Carefully add the ibuprofen API and microcrystalline cellulose to a high-speed mixer and mix at a speed of 1200 r / min for 12 minutes to ensure thorough mixing of the materials. Dissolve PVP in ethanol to prepare a binder solution with a mass concentration of 10%. Spray the binder solution evenly into the mixed materials and dry at a low temperature of 45°C. Then granulate through a 35-mesh sieve to remove large-volume particles. Next, add croscarmellose sodium and magnesium stearate and mix in a three-dimensional mixer at a speed of 40 r / min for 18 minutes. Finally, use the tablet preparation powder press provided by the present invention to press tablets, controlling the pressure at 12 kN.

[0056] Example 2

[0057] Weigh 100 g of ibuprofen API, 180 g of microcrystalline cellulose, 8 g of PVP, 80 g of ethanol, 3 g of croscarmellose sodium, and 1.5 g of magnesium stearate. Add the ibuprofen API and microcrystalline cellulose to a high-speed mixer and mix at a speed of 1000 r / min for 15 minutes. Dissolve PVP in ethanol to prepare a binder solution with a mass concentration of 8%. Spray the binder solution evenly into the mixed materials and dry at a low temperature of 40°C. Then granulate through a 30-mesh sieve to remove large-volume particles. Next, add croscarmellose sodium and magnesium stearate and mix in a three-dimensional mixer at a speed of 30 r / min for 20 minutes. Finally, use the tablet preparation powder press provided by the present invention to press tablets, controlling the pressure at 10 kN.

[0058] Example 3

[0059] Weigh 100 g of ibuprofen API, 200 g of microcrystalline cellulose, 9 g of PVP, 90 g of ethanol, 3.5 g of croscarmellose sodium, and 1.8 g of magnesium stearate. Add the ibuprofen API and microcrystalline cellulose to a high-speed mixer and mix at a speed of 1300 r / min for 13 minutes. Dissolve PVP in ethanol to prepare a binder solution with a mass concentration of 9%. Spray the binder solution evenly into the mixed materials through spraying and dry at a low temperature of 50°C. Then granulate through a 40-mesh sieve to remove large-volume particles. Next, add croscarmellose sodium and magnesium stearate and mix in a three-dimensional mixer at a speed of 45 r / min for 17 minutes. Finally, use the tablet preparation powder press provided by the present invention to press tablets, controlling the pressure at 13 kN.

[0060] The products of the above Examples 1, 2, and 3 were tested. The weight variation of tablets was controlled within ±5%, the hardness was greater than 50 N, the dissolution rate at 30 minutes reached over 85%. After 6-month accelerated test and long-term stability test, the content change was less than 3%, and the impurity content met the pharmacopoeia standards. The tablets prepared by the preparation process provided by the present invention have stronger stability, longer shelf life, while ensuring the uniform quality of tablets, more stable and reliable efficacy per tablet, and significantly improving the dissolution rate of ibuprofen, enabling the drug effect to be exerted faster.

[0061] Please refer to Figures 2 - 17 , the present invention also provides a powder tablet press for tablet preparation, including a vertical frame 1, a suction-type upper die set, a lower die set, and a conveyor belt 9. The lower die set is arranged on the side of the vertical frame 1 and can be adjusted up and down. The suction-type upper die set is arranged on the side of the vertical frame 1 and above the lower die set, and can be adjusted up and down and back and forth. The conveyor belt 9 is installed on the side of the vertical frame 1 and between the suction-type upper die and the lower die set, and extends left and right. The suction-type upper die set and the lower die set are used in combination to press the powder material 02 into a tablet body 01. The suction-type upper die set includes a number of evenly distributed upper pressing die heads 4. The bottom end of each upper pressing die head 4 has a negative pressure suction effect for sucking and transferring the pressed tablet body 01 onto the conveyor belt 9.

[0062] When the powder tablet press for tablet preparation provided by the present invention is in use, the lower die set moves upward and the suction-type upper die set moves downward to press the powder material 02 into a tablet body 01 in a cooperative manner. After pressing, the bottom end of each upper pressing die head 4 in the suction-type upper die set sucks and holds the tablet body 01. Then the suction-type upper die set moves backward until it is above the conveyor belt 9, and then moves downward until the bottom of the tablet body 01 touches the conveyor belt 9. After that, the suction at the bottom end of each upper pressing die head 4 is cancelled, and the tablet body 01 is released onto the conveyor belt 9. Subsequently, the suction-type upper die set first moves upward and then moves forward to reset above the lower die set for the next batch of tablet pressing processing.

[0063] When transferring and releasing the tablet body 01 onto the conveyor belt 9, the conveyor belt 9 stops running to avoid damage to the tablet body 01 caused by friction between the tablet body 01 and the surface of the conveyor belt 9. The pressed tablet body 01 is sucked by the lower end of the upper pressing die head 4 and transferred onto the conveyor belt 9, and the positions of the upper pressing die heads 4 are evenly distributed. Compared with the traditional tablet press discharging method, during the discharging and transferring process of the tablet body 01, the tablet bodies 01 can be arranged in an orderly manner, so that the tablet body 01 will not collide or rub against adjacent tablet bodies 01, the receiving plate, and other components, thereby effectively ensuring the appearance quality and integrity of the tablet body 01.

[0064] In addition, please refer to Figure 16, on the conveyor belt 9, there are material trays 91 placed at equal intervals. A number of placement grooves 92 for placing tablet bodies 01 are evenly distributed on the material trays 91. The positions of the placement grooves 92 correspond one-to-one with the positions of the upper pressing die heads 4. When the suction-type upper module transfers the pressed tablet bodies 01 to the conveyor belt 9, the placement grooves 92 on the empty material trays 91 correspond one-to-one with the positions of the tablet bodies 01. When the suction-type upper module descends, the tablet bodies 01 are transferred one-to-one into the placement grooves 92 in an orderly manner, realizing the orderly arrangement of the tablet bodies 01, so as to detect and blister-pack the tablet bodies 01. Subsequently, there is no need to additionally arrange the tablet bodies 01, reducing the process and the time-consuming of the processing process, and improving the production efficiency.

[0065] Please refer to Figure 3 , Figure 4 and Figure 5 , on the side of the vertical frame 1 between the conveyor belt 9 and the lower module, an installation table 2 is installed through the first cross frame 11. A number of vertically penetrating sliding holes 21 are evenly distributed on the installation table 2. The positions of the sliding holes 21 correspond one-to-one with the positions of the upper pressing die heads 4. The lower module includes a tablet pressing cylinder body 3, a sliding rod 31, a lower pressing die head 32, a first hydraulic cylinder 34, and a second hydraulic cylinder 37. On both side surfaces of the installation table 2, the first hydraulic cylinders 34 with telescopic rods facing down are vertically fixed through the first side frames 33. The end parts of the telescopic rods of the two first hydraulic cylinders 34 are both fixed with second side frames 35. A first mounting plate 36 is fixed between the two second side frames 35. A number of tablet pressing cylinder bodies 3 corresponding one-to-one with the positions of the sliding holes 21 are evenly distributed on the first mounting plate 36. The openings of the tablet pressing cylinder bodies 3 are all arranged upward. A lower pressing die head 32 is slidably installed in each tablet pressing cylinder body 3 in a matching manner. A vertically extending sliding rod 31 is fixed to the bottom of each lower pressing die head 32. The sliding rods 31 all slide through and extend below the tablet pressing cylinder bodies 3. Second hydraulic cylinders 37 extending vertically are fixed to both sides of the first mounting plate 36 respectively. The telescopic rods of the two second hydraulic cylinders 37 all face down, and the end parts are jointly fixed with a second mounting plate 38. The sliding rods 31 are all fixedly connected to the second mounting plate 38.

[0066] By the telescopic operation of the first hydraulic cylinder 34, the overall lifting adjustment of the first mounting plate 36, the tablet pressing cylinder body 3, the sliding rod 31, and the lower pressing die head 32 can be driven. By the telescopic operation of the second hydraulic cylinder 37, the relative movement adjustment of the second mounting plate 38, the sliding rod 31, and the lower pressing die head 32 relative to the tablet pressing cylinder body 3 can be driven. During the process of the first hydraulic cylinder 34 retracting and driving the tablet pressing cylinder body 3 to rise, the tablet pressing cylinder body 3 can pass through the sliding holes 21 and extend above the installation table 2. The outer wall of the tablet pressing cylinder body 3 will closely slide and fit with the inner wall of the sliding holes 21, avoiding the situation of powder leakage due to too large a gap between the outer wall of the tablet pressing cylinder body 3 and the inner wall of the sliding holes 21.

[0067] Please refer to Figure 3 , Figure 6 and Figure 7, the suction - type upper module further includes a piston rod 44, a plugging head 45, a piston body 46, a second power guide rail 8, a third liquid oxygen cylinder 83, and a fourth liquid oxygen cylinder 86. The second power guide rail 8 is installed on the side of the vertical frame 1. A second moving seat 81 capable of moving back and forth is installed below the second power guide rail 8. An installation seat 82 is fixed below the second moving seat 81. On both sides of the lower surface of the installation seat 82, third liquid oxygen cylinders 83 vertically downward are respectively fixed. A third mounting plate 84 is commonly fixed on the ends of the telescopic rods of the two third liquid oxygen cylinders 83. The upper pressing dies 4 are all fixed on the third mounting plate 84, and the upper pressing dies 4 can all be inserted into the tablet - pressing cylinder body 3 in a one - to - one corresponding manner. Among them, when the upper pressing die 4 is inserted into the tablet - pressing cylinder body 3, the outer wall of the upper pressing die 4 is in close sliding fit with the inner wall of the tablet - pressing cylinder body 3, preventing the leakage of powder due to a large gap between the outer wall of the upper pressing die 4 and the inner wall of the tablet - pressing cylinder body 3.

[0068] Piston cavities 43 are provided in the upper pressing dies 4. Suction holes 42 communicating with the piston cavities 43 are provided at the bottom ends of the upper pressing dies 4. Third side frames 85 are fixed on both side surfaces of the third mounting plate 84. Fourth liquid oxygen cylinders 86 are vertically fixed on the two third side frames 85. Fourth side frames 87 are fixed on the ends of the telescopic rods of the two fourth liquid oxygen cylinders 86. A fourth mounting plate 88 is fixed between the two fourth side frames 87. A number of piston rods 44 are evenly distributed and fixed below the fourth mounting plate 88. Each piston rod 44 slides into the piston cavity 43 in a one - to - one corresponding manner. A plugging head 45 that is slidably and fittingly clamped in the suction hole 42 is fixed at the bottom end of each piston rod 44. The plugging head 45 is used to complete the pressing surface at the bottom end of the upper pressing die 4, ensuring the forming quality of the tablet body 01. Piston bodies 46 that are in close movable fit with the inner wall of the piston cavity 43 are fixed on the outer walls of each piston rod 44.

[0069] When the second power guide rail 8 works, the second moving seat 81 can drive the installation seat 82 to move back and forth, for transferring the formed tablet body 01 to the conveyor belt 9. By the telescopic work of the third liquid oxygen cylinder 83, the third mounting plate 84 and the components thereon can be driven to perform lifting adjustment. By the telescopic work of the fourth liquid oxygen cylinder 86, the fourth mounting plate 88 and the components thereon can be driven to perform lifting adjustment relative to the upper pressing die 4. When the fourth liquid oxygen cylinder 86 extends, it can drive the third liquid oxygen cylinder 83, the piston rod 44, the plugging head 45, and the piston body 46 to move upward relative to the upper pressing die 4. The piston body 46 slides upward along the inner wall of the piston cavity 43, generating negative pressure, for sucking and holding the tablet body 01 at the bottom end of the upper pressing die 4.

[0070] It should be noted that the outer wall of the plugging head 45 is in close sliding fit with the inner wall of the suction hole 42, and air can flow in the small gap between the two.

[0071] Please refer to Figure 5 and Figure 7, the top of the lower pressing die head 32 is provided with a lower die concave hole 321, the aperture of the lower die concave hole 321 becomes smaller downward, the bottom end of the upper pressing die head 4 is provided with an upper die concave hole 41, the aperture of the upper die concave hole 41 becomes larger upward, the suction hole 42 communicates with the upper die concave hole 41. During tablet pressing, the bottom end surface of the plugging head 45 is flush with the inner end wall of the upper die concave hole 41, supplementing the inner end wall of the upper die concave hole 41 to be flat, ensuring the forming quality of the tablet body 01. When the upper pressing die head 4 is inserted into the tablet pressing cylinder body 3 for tablet pressing, the powder material 02 is formed in the die cavity formed between the upper die concave hole 41 and the lower die concave hole 321.

[0072] The powder material 02 is loaded into the tablet pressing cylinder body 3 above the lower pressing die head 32, and the upper pressing die head 4 is inserted into the tablet pressing cylinder body 3. As Figure 11 shown, the lower pressing die head 32 moves upward, and the upper pressing die head 4 moves downward, and the powder material 02 can be pressed into the tablet body 01. The tablet body 01 is formed in the die cavity formed between the upper die concave hole 41 and the lower die concave hole 321. Due to the fact that the aperture of the lower die concave hole 321 becomes smaller downward and the aperture of the upper die concave hole 41 becomes larger upward, as Figure 12 shown, the two ends of the formed tablet body 01 are in a chamfered shape that gradually converges towards the axis. The contact area between the outer peripheral wall of the tablet body 01 and the inner wall of the tablet pressing cylinder body 3 is small, and the friction during demolding is small, ensuring that the process of demolding the tablet body 01 from the tablet pressing cylinder body 3 to the outside is easier and smoother. At the same time, during the blister packaging process, the tablet body 01 with chamfered ends is more likely to accurately fall into the blister, improving the accuracy and speed of filling, and also facilitating users to take out the medicine for taking.

[0073] The specific steps of pressing the powder material 02 into the tablet body 01 and transferring it to the conveyor belt 9 are as follows:

[0074] Fill the powder material 02 into each tablet pressing cylinder body 3. The powder material 02 is temporarily stored above the lower pressing die head 32 in the tablet pressing cylinder body 3. Then, the tablet pressing cylinder body 3 moves upward to the limit position. Subsequently, the upper pressing die head 4 moves downward and correspondingly inserts into the tablet pressing cylinder body 3. While the upper pressing die head 4 moves downward, the lower pressing die head 32 moves upward, and the lower pressing die head 32 and the upper pressing die head 4 approach each other relatively, and finally the powder material 02 is pressed into the tablet body 01;

[0075] The piston rod 44 drives the plugging head 45 and the piston body 46 to move upward. Since the tablet body 01 fits in the upper die concave hole 41, as Figure 13 shown, the arrow in the figure indicates the moving direction of the piston body 46. The piston body 46 moves upward, generating negative pressure in the piston cavity 43 to hold the tablet body 01;

[0076] The slide bar 31 and the upper pressing die head 4 move upward synchronously, driving the tablet body 01 to move upward, so as to demold the tablet body 01 from the top opening of the tablet pressing cylinder body 3 to the outside. The lower pressing die head 32 provides a thrust support at the bottom of the tablet body 01 to prevent the tablet body 01 held in the upper die concave hole 41 from falling off due to the friction between the lower pressing die head 32 and the inner wall of the tablet pressing cylinder body 3;

[0077] The third mounting plate 84 moves backward, driving the demolded tablet body 01 to move above the conveyor belt 9, and the tablet body 01 is aligned with each placement groove 92 one by one. Then the third mounting plate 84 moves downward until the tablet body 01 falls into each placement groove 92. Subsequently, the piston rod 44 drives the piston body 46 and the suction hole 42 to move downward to cancel the negative pressure and release the tablet body 01;

[0078] The third mounting plate 84 moves upward to reset, and then the mounting seat 82 moves forward to reset, so that each upper pressing die head 4 is reset. During this process, the first mounting plate 36 moves downward to drive the tablet pressing cylinder body 3 to move downward to reset.

[0079] Please refer to Figure 2 、 Figure 3 、 Figure 8 、 Figure 9 and Figure 10 As shown in

[0080] A rectangular frame body 5 is fixed on the upper surface of the mounting table 2 and is distributed around the periphery of the sliding hole 21. One side of the rectangular frame body 5 is the A side 51, and the other side is the B side 52. A second cross frame 12 is fixed on the side surface of the vertical frame 1. A feeder 13 is fixed at the end of the second cross frame 12. A feeding pipe 14 is arranged below the feeder 13. The bottom end of the feeding pipe 14 is close to the A side 51 of the rectangular frame body 5. The powder material 02 in the feeder 13 falls into the feeding pipe 14 and is discharged from the bottom of the feeding pipe 14 to realize feeding.

[0081] By operating through the first power guide rail 61, the first moving seat 62 can be driven to move. Under the connection of the connection wall 63 and the side plate 64, the storage cavity 601 formed between the two partition plates 6 can be driven to reciprocate horizontally between the A side 51 and the B side 52. The side plate 64 is used to block the parts of the side portions of the two partition plates 6 that exceed the upper part of the rectangular frame 5 to prevent the powder material 02 from leaking out. At the same time, it also acts as a driving connection member, killing two birds with one stone.

[0082] When filling the tablet pressing cylinder 3, the top of the tablet pressing cylinder 3 is inserted into the sliding hole 21, and at the same time, the top end of the tablet pressing cylinder 3 is flush with the upper surface of the mounting table 2. When the two partition plates 6 move from the A side 51 to the B side 52 and pass through the sliding hole 21, the powder material 02 in the storage cavity 601 will fall downward into the corresponding tablet pressing cylinder 3, realizing the filling of the powder material 02 in the tablet pressing cylinder 3. In addition, since the bottom end of the partition plate 6 is in sliding fit with the upper surface of the mounting table 2, the powder material 02 on the top of the tablet pressing cylinder 3 can be scraped flat. After successive tablet pressing and the tablet pressing cylinder 3 moves downward and resets to the sliding hole 21 and is flush with the upper surface of the mounting table 2 again, the two partition plates 6 move from the B side 52 to the A side 51. Similarly, the tablet pressing cylinder 3 can be filled again. After two fillings, the amount of the powder material 02 in the storage cavity 601 decreases. At this time, the two partition plates 6 at the A side 51 are under the feeding pipe 14, and the powder material 02 is conveyed to the storage cavity 601 by the feeding pipe 14, realizing the replenishment of the powder material 02. That is, in one reciprocating movement cycle of the two partition plates 6, two filling and scraping actions can be realized. After resetting to the A side 51, the powder material 02 can be replenished.

[0083] Among them, as Figure 5 shown, the top end of each tablet pressing cylinder 3 has an annular inclined slope 301, and the diameter of the inclined slope 301 becomes larger downward. When filling with the upper surface of the tablet pressing cylinder 3 flush with the upper surface of the mounting table 2, as Figure 17 shown, due to the gap formed between the inclined slope 301 at the top of the tablet pressing cylinder 3 and the inner wall of the sliding hole 21, after the partition plate 6 scrapes flat, the powder material 02 will remain in this gap. After the tablet pressing cylinder 3 moves upward, the powder material 02 remaining in this gap can be pushed out. Due to the sloping design of the top of the tablet pressing cylinder 3, the stay of the powder material 02 is reduced, and the powder material 02 is conveyed and falls back into the rectangular frame 5. With the repeated movement, filling and scraping of the partition plate 6, this part of the powder material 02 will be pushed and scraped back into the tablet pressing cylinder 3 again, avoiding waste of the powder material 02 and improving the utilization rate of the powder material 02.

[0084] A bidirectional threaded rod 71 is rotatably installed between the two side plates 64, one end of the bidirectional threaded rod 71 extends through and extends to the outside of the corresponding side plate 64, and is fixedly mounted with a gear 72. A rack 73 parallel to the length direction of the first power guide rail 61 is fixed on the corresponding side surface of the rectangular frame 5, and the rack 73 is meshed with the gear 72. A pair of scrapers 7 are limitedly slidably installed between the two partitions 6. The two scrapers 7 are respectively mounted on both sides of the bidirectional threaded rod 71 through the matching screw holes thereon. When the two partitions 6 move from the A side 51 to the B side 52, the two scrapers 7 move away from each other. When the two partitions 6 move from the B side 52 to the A side 51, the two scrapers 7 approach each other, and when the two partitions 6 move to the A side 51 to the extreme position, the two scrapers 7 are fitted and centered.

[0085] When the two partitions 6 are located at the A side 51, the two scrapers 7 are in contact with each other and centered. At this time, the feed pipe 14 replenishes the powder material 02 into the storage chamber 601. Since the bottom end of the feed pipe 14 is facing the middle of the storage chamber 601, Figure 14 As shown, the powder material 02 will accumulate in the middle of the storage chamber 601, and is distributed in a state of high in the middle and low on the periphery. When the two partitions 6 move from the A side 51 to the B side 52, the rack 73 is driven to engage the driving gear 72 and drive the bidirectional threaded rod 71 to rotate. The rotating bidirectional threaded rod 71 drives the two scrapers 7 to move away from each other. Figure 15 As shown in the figure, the arrows indicate the movement directions of the two scrapers 7. The two scrapers 7 can push the powder material 02 in the middle to both sides to ensure that the powder material 02 is evenly distributed in the storage chamber 601, and avoid insufficient powder material 02 in the two side areas of the storage chamber 601 to complete the filling of the tablet pressing cylinder 3. When the two partitions 6 retreat from the B side 52 to the A side 51, the rack 73 engages the driving gear 72 and drives the bidirectional threaded rod 71 to rotate in the opposite direction, thereby driving the two scrapers 7 to approach each other until they are in contact.

[0086] Secondly, during the movement of the two partitions 6, the meshing transmission of the gear 72 and the rack 73 is used as the driving source for the rotation of the bidirectional threaded rod 71, thereby eliminating the need to set up additional driving, thereby reducing manufacturing costs.

[0087] It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention.

Claims

1. A tablet preparation process, characterized in that: Initial mixing: ibuprofen API and microcrystalline cellulose are put into a high-speed mixer at a mass ratio of 1:1.5-1:2, and mixed at a speed of 1000-1500 r / min for 10-15 minutes to obtain an initial mixture, wherein the active pharmaceutical ingredient is ibuprofen API; Granulation: PVP and ethanol are prepared into a binder solution with a mass concentration of 8%-10%, and the binder solution is sprayed into the primary mixed material by spraying, and then low-temperature drying is performed at 40-50°C after spraying to obtain a powder; Granulation: the powder is sieved through a 30-40 mesh screen to obtain fine powder; Total mixing: adding 1%-3% of cross-linked sodium carboxymethyl cellulose and 0.5%-1% of magnesium stearate by mass ratio to the fine powder, placing the mixture in a three-dimensional mixer, and mixing the mixture at a speed of 30-50 r / min for 15-20 minutes to obtain a powder material; Tableting: The powder material is compressed into tablets using a tablet preparation powder press, and the pressure range is controlled at 10-15 kN.

2. A tablet preparation powder tablet press, applied to a tablet preparation process according to claim 1, characterized in that: It comprises a stand (1), a suction-holding upper die set, a lower die set and a conveyor belt (9); The lower mold assembly is arranged on the side of the stand (1) and can be raised and lowered; The suction-holding upper die set is arranged on the side of the stand (1) and is located above the lower die set, and can be raised and lowered and moved forward and backward in translation; The conveyor belt (9) is installed on the side of the stand (1) and is located between the suction-holding upper mold and the lower mold assembly, and extends left and right; The suction-holding upper die set and the lower die set are used in combination to press the powder material (02) into tablets (01); The suction-type upper die set comprises a plurality of evenly distributed upper pressing dies (4), the bottom end of each of the upper pressing dies (4) having a negative pressure suction effect, which is used to suction and transfer the pressed tablet body (01) to the conveyor belt (9).

3. A tablet preparation powder tablet press according to claim 2, characterized in that: A mounting platform (2) is installed on the side of the vertical frame (1) between the conveyor belt (9) and the lower die set through a first horizontal frame (11), and a plurality of vertically penetrating sliding holes (21) are evenly distributed on the mounting platform (2), and the positions of the sliding holes (21) correspond one-to-one to the positions of the upper die head (4); The lower die assembly comprises a tablet pressing cylinder (3), a slide rod (31), a lower pressing die head (32), a first hydraulic cylinder (34) and a second hydraulic cylinder (37); The first hydraulic cylinders (34) with telescopic rods facing downwards are vertically fixed to the two side surfaces of the mounting platform (2) through first side frames (33), and second side frames (35) are fixed to the ends of the telescopic rods of the two first hydraulic cylinders (34); A first mounting plate (36) is fixed between the two second side frames (35), and a plurality of the tablet pressing cylinders (3) corresponding to the positions of the slide holes (21) are evenly distributed on the first mounting plate (36); The openings of the tablet pressing cylinders (3) are all arranged upwards, and the lower pressing die head (32) is slidably mounted in each of the tablet pressing cylinders (3). A vertically extending sliding rod (31) is fixed at the bottom of each of the lower pressing die heads (32), and the sliding rod (31) is slidably penetrated and extended to the bottom of the tablet pressing cylinder (3); A second hydraulic cylinder (37) extending vertically is fixed on both sides of the first mounting plate (36), the telescopic rods of the two second hydraulic cylinders (37) are both downwardly facing, and the ends are commonly fixed with a second mounting plate (38), and the sliding rods (31) are fixedly connected to the second mounting plate (38).

4. A tablet preparation powder tablet press according to claim 3, characterized in that: The suction-holding upper die assembly also includes a piston rod (44), a plugging head (45), a piston body (46), a second power guide rail (8), a third liquid oxygen cylinder (83) and a fourth liquid oxygen cylinder (86); The second power rail (8) is installed on the side of the stand (1), a second movable seat (81) capable of moving forward and backward is installed below the second power rail (8), a mounting seat (82) is fixed below the second movable seat (81), and the third liquid oxygen cylinders (83) facing vertically downward are respectively fixed on both sides of the lower surface of the mounting seat (82), and a third mounting plate (84) is commonly fixed on the ends of the telescopic rods of the two third liquid oxygen cylinders (83), and the upper die heads (4) are all fixed on the third mounting plates (84); The upper pressing die heads (4) can be inserted into the tablet pressing cylinder (3) in a one-to-one matching manner; The upper die head (4) is provided with a piston cavity (43), and the bottom end of the upper die head (4) is provided with a suction hole (42) connected with the piston cavity (43); Third side frames (85) are fixed to both side surfaces of the third mounting plate (84), the fourth liquid oxygen cylinder (86) is vertically fixed to the two third side frames (85), the ends of the telescopic rods of the two fourth liquid oxygen cylinders (86) are fixed to fourth side frames (87), a fourth mounting plate (88) is fixed between the two fourth side frames (87), and a plurality of piston rods (44) are evenly fixed below the fourth mounting plate (88); Each of the piston rods (44) is slidably extended into the piston cavity (43) in a one-to-one manner, and a sealing head (45) is fixed at the bottom end of each of the piston rods (44) and is slidably matched and clamped in the suction hole (42). A piston body (46) is fixed on the outer wall of each of the piston rods (44) and is tightly and movably fitted with the inner wall of the piston cavity (43).

5. A tablet preparation powder tablet press according to claim 4, characterized in that: The top of the lower die head (32) is provided with a lower die concave hole (321), and the diameter of the lower die concave hole (321) decreases as it goes downwards; The bottom end of the upper die head (4) is provided with an upper die concave hole (41), and the diameter of the upper die concave hole (41) increases upwards; The suction hole (42) is in communication with the upper die concave hole (41), and during tableting, the bottom end surface of the plugging head (45) is kept flush with the inner end wall of the upper die concave hole (41); When the upper die head (4) is inserted into the tablet pressing cylinder (3) for tablet pressing, the powder material (02) is formed in the die cavity formed between the upper die concave hole (41) and the lower die concave hole (321).

6. A tablet preparation powder tablet press according to claim 3, characterized in that: The top end of each tablet pressing cylinder (3) has an annular slope (301), and the diameter of the slope (301) increases as it goes downwards.

7. A tablet preparation powder tablet press according to claim 3, characterized in that: A rectangular frame (5) is fixed on the upper surface of the mounting platform (2) and is distributed around the periphery of the sliding hole (21), wherein one side of the rectangular frame (5) is the A side (51) and the other side is the B side (52); A second horizontal frame (12) is fixed on the side of the vertical frame (1), a feeder (13) is fixed at the end of the second horizontal frame (12), and a feed pipe (14) is provided below the feeder (13); The bottom end of the feed pipe (14) is close to the A side (51) of the rectangular frame (5).

8. A tablet preparation powder tablet press according to claim 7, characterized in that: A pair of partitions (6) are installed in the rectangular frame (5), and both of the partitions (6) extend beyond the top of the rectangular frame (5); The two side end surfaces of the two partitions (6) are respectively slidably fitted with the inner side walls of the rectangular frame (5), and the bottom ends of the two partitions (6) are slidably fitted with the upper surface of the mounting platform (2); A material storage cavity (601) for storing powder material (02) is formed between the two partitions (6) and the inner walls on both sides of the mounting platform (2); First power rails (61) are respectively installed on both sides of the rectangular frame (5), and movable first moving seats (62) are installed on the two first power rails (61), and connecting walls (63) are fixed on the tops of the two first moving seats (62); Side plates (64) are fixed to both side ends of the two partitions (6) and located above the rectangular frame (5), and the bottoms of the two side plates (64) are respectively slidably fitted to the upper end surfaces of the rectangular frame (5); The two connecting walls (63) are respectively fixedly connected to the side plates (64) on the corresponding sides; When the two partitions (6) move to the A side (51) to the extreme position, the bottom end of the feed pipe (14) faces the middle of the storage chamber (601).

9. A tablet preparation powder tablet press according to claim 8, characterized in that: A bidirectional threaded rod (71) is rotatably mounted between the two side plates (64), one end of the bidirectional threaded rod (71) extends through and extends to the outside of the corresponding side plate (64) and is fixedly sleeved with a gear (72); A rack (73) parallel to the length direction of the first power guide rail (61) is fixed on the corresponding side surface of the rectangular frame (5), and the rack (73) is meshed with the gear (72) correspondingly; A pair of scrapers (7) are installed between the two partitions (6) in a limited sliding manner, and the two scrapers (7) are respectively sleeved on both sides of the bidirectional threaded rod (71) through thread matching of the screw holes thereon; When the two partitions (6) move from the A side (51) to the B side (52), the two scrapers (7) move away from each other; When the two partitions (6) move from the B side (52) to the A side (51), the two scrapers (7) approach each other, and when the two partitions (6) move to the A side (51) to the extreme position, the two scrapers (7) fit in the middle.

10. A powder tablet press for tablet preparation according to claim 2, characterized in that: Material trays (91) are placed at equal intervals on the conveyor belt (9), and a plurality of placement slots (92) for placing tablet bodies (01) are evenly distributed on the material tray (91); The position of the placement groove (92) corresponds one-to-one to the position of the upper die head (4).

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