Sample detection device, sample detection method, and sample analyzer
By introducing the design of heating components and control components into the sample detection device, the problem of abnormal changes in the sample due to excessive waiting time is solved, and the accuracy and reliability of sample detection are improved.
Patent Information
- Application Number
- CN202311626858.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-11-29
- Publication Date
- 2025-05-30
AI Technical Summary
When the waiting time of the existing sample detection device is too long, the samples in the test tube may change abnormally due to the low temperature, thereby reducing the accuracy and reliability of the detection results.
A sample detection device is designed, including an injection assembly, a sampling assembly, a heating assembly and a control assembly. When the test result is abnormal, the device moves the test tube to the heating assembly for heating and re-tests the sample to obtain more accurate results.
By heating the sample and re-testing, the accuracy and reliability of sample detection can be improved, and abnormal detection results can be avoided due to excessive waiting time.
Smart Images
Figure CN120064679A_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of detection technologies, and particularly to a sample detection device, a sample detection method, and a sample analyzer. Background Art
[0002] In the prior art, existing sample detection devices usually integrate functions such as sample injection, sampling, and sample detection to achieve sample detection of samples.
[0003] The defect of the prior art is that when performing sample detection of samples, if there are too many test tubes containing samples, or there are other reasons that cause too long waiting time, abnormal phenomena (such as cold agglutination phenomenon) are likely to occur in the test tubes containing samples with a later order. The detection results obtained by the existing sample detection devices based on such test tubes are less accurate, so the reliability of existing sample detection is poor. Summary of the Invention
[0004] The main technical problem to be solved by this application is how to improve the reliability of sample detection.
[0005] To solve the above technical problem, the first technical solution adopted by this application is: a sample detection device, including: a sample injection component for moving a test tube containing a sample; a sampling component for collecting the sample in the test tube and transporting it to a detection component, and the detection component for performing sample detection on the corresponding sample; a heating component for heating the corresponding test tube; a control component for: controlling the sample injection component to move a first test tube containing a first sample to the sampling component; controlling the sampling component to collect the first sample in the first test tube and transport it to the detection component, so that the detection component performs sample detection on the first sample to obtain a first detection result; in response to the first detection result being abnormal, controlling the sample injection component to move the first test tube to the heating component; controlling the heating component to heat the first test tube; controlling the sample injection component to move the heated first test tube to the sampling component; controlling the sampling component to collect the first sample in the first test tube and transport it to the detection component, so that the detection component performs sample detection on the first sample to obtain a second detection result.
[0006] Among them, the sample injection assembly includes an injector, a gripper, and a relay assembly; controlling the sample injection assembly to move the first test tube containing the first sample to the sampling assembly includes: controlling the injector to move the first test tube to the gripper; controlling the gripper to clamp and swing the first test tube, and move the swung first test tube to the relay assembly; controlling the relay assembly to move the first test tube to the sampling assembly; in response to an abnormal first test result, controlling the sample injection assembly to move the first test tube to the heating assembly, including: in response to an abnormal first test result, controlling the gripper to move the first test tube to the heating assembly; controlling the sample injection assembly to move the heated first test tube to the sampling assembly, including: controlling the gripper to clamp and swing the first test tube, and move the heated and swung first test tube to the relay assembly; controlling the relay assembly to move the first test tube to the sampling assembly.
[0007] Among them, the sample detection device further includes: a vibration assembly for eccentrically vibrating the corresponding test tube; the control assembly is further configured to: control the sample injection assembly to move the second test tube containing the second sample to the vibration assembly; wherein, the content of the second sample in the second test tube is less than the content of the first sample in the first test tube; control the vibration assembly to perform eccentric vibration on the second test tube; control the sample injection assembly to move the vibrated second test tube to the sampling assembly; control the sampling assembly to collect the second sample in the second test tube and transport it to the detection assembly, so that the detection assembly performs sample detection on the second sample to obtain a third test result.
[0008] Among them, the sample detection device includes a mixing assembly, the mixing assembly includes a heating assembly and a vibration assembly, and the sample injection assembly includes an injector, a gripper, and a relay assembly; the injector is used to move the test tube containing the sample to the clamping position; the gripper is used to move to the clamping position, clamp the test tube from the clamping position, and move the clamped test tube to the mixing position or the relay position; the mixing assembly is used to move to the mixing position and heat or vibrate the test tube at the mixing position; the relay assembly is used to move to the relay position, so that the gripper moves the test tube onto the relay assembly and moves the test tube to the sampling position; the sampling assembly is used to move to the sampling position, collect the sample from the test tube at the sampling position, and transport the collected sample to the detection assembly for sample detection.
[0009] Among them, before controlling the sample injection component to move the test tube containing the sample, the control component is further configured to: in response to the sampling component not being in the first initial position, control the sampling component to move to the first initial position; wherein, the sampling component is used to move between the first initial position and the sampling position; in response to the mixing component not being in the second initial position, control the mixing component to move to the second initial position; wherein, the mixing component is used to move between the second initial position and the mixing position; in response to the relay component not being in the third initial position, control the relay component to move to the third initial position; wherein, the relay component is used to move between the relay position and the sampling position, and the third initial position is located between the relay position and the sampling position; control the gripper to perform a self-check moving action, and control the gripper to perform clamping and releasing actions to achieve self-checking.
[0010] Among them, before controlling the sample injection component to move the test tube containing the sample, the control component is further configured to: in response to the gripper not being in the fourth initial position, control the gripper to move to the fourth initial position; wherein, the gripper is used to move between the fourth initial position, the mixing position and the relay position, and the fourth initial position is above the mixing position or the relay position; control the mixing component to perform a self-check moving action to achieve self-checking.
[0011] Among them, before controlling the sample injection component to move the test tube containing the sample, the control component is further configured to: in response to the gripper not being in the fourth initial position, control the gripper to move to the fourth initial position; wherein, the gripper is used to move between the fourth initial position, the mixing position and the relay position, and the fourth initial position is above the mixing position or the relay position; in response to the sampling component not being in the first initial position, control the sampling component to move to the first initial position; wherein, the sampling component is used to move between the first initial position and the sampling position; in response to the mixing component not being in the second initial position, control the mixing component to move to the second initial position; wherein, the mixing component is used to move between the second initial position and the mixing position; control the relay component to perform a self-check moving action to achieve self-checking.
[0012] Among them, before controlling the sample injection component to move the test tube containing the sample, the control component is further configured to: in response to the gripper not being in the fourth initial position, control the gripper to move to the fourth initial position; wherein, the gripper is used to move between the fourth initial position, the mixing position and the relay position, and the fourth initial position is above the mixing position or the relay position; in response to the mixing component not being in the second initial position, control the mixing component to move to the second initial position; wherein, the mixing component is used to move between the second initial position and the mixing position; in response to the sampling component not being in the first initial position, control the sampling component to move to the first initial position; wherein, the sampling component is used to move between the first initial position and the sampling position; in response to the relay component not being in the third initial position, control the relay component to move to the third initial position; wherein, the relay component is used to move between the relay position and the sampling position, and the third initial position is located between the relay position and the sampling position; control the sampling component to perform a self-check moving action.
[0013] To solve the above technical problems, the second technical solution adopted in this application is: a sample detection method applied to the above sample detection device; the sample detection method includes: controlling the sample injection component to move the first test tube containing the first sample to the sampling component; controlling the sampling component to collect the first sample in the first test tube and transport it to the detection component, so that the detection component performs sample detection on the first sample to obtain a first detection result; in response to the abnormality of the first detection result, controlling the sample injection component to move the first test tube to the heating component; controlling the heating component to heat the first test tube; controlling the sample injection component to move the heated first test tube to the sampling component; controlling the sampling component to collect the first sample in the first test tube and transport it to the detection component, so that the detection component performs sample detection on the first sample to obtain a second detection result.
[0014] To solve the above technical problems, the third technical solution adopted in this application is: a sample analyzer including the above sample detection device.
[0015] The beneficial effect of this application is as follows: Different from the prior art, in the technical solution of this application, after performing sample detection on the first sample, the obtained first detection result can be analyzed. If the first detection result is abnormal, the first test tube can be reheated, and the first sample in the heated first test tube can be subjected to sample detection again. The obtained second detection result is used as the final detection result. Based on the above method, when it is determined that the first detection result is abnormal, the first test tube can be reheated, and the first sample in the first test tube can be subjected to sample detection again to obtain a second detection result, and this is used as the final detection result. Based on the above method, when the first sample in the first test tube undergoes abnormal changes due to low temperature because of waiting for sample detection for too long, by heating the first sample and performing sample detection on the first sample again, a second detection result with higher accuracy than the first detection result is obtained and used as the final detection result, improving the reliability of sample detection. Description of the Drawings
[0016] To more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.
[0017] Figure 1 is an axonometric schematic diagram of an embodiment of the sample detection device of this application;
[0018] Figure 2 is one of the structural schematic diagrams of an embodiment of the sample detection device of this application;
[0019] Figure 3 It is the second structural schematic diagram of an embodiment of the sample detection device of the present application;
[0020] Figure 4 It is the flowchart of an embodiment of the sample detection method of the present application;
[0021] Figure 5 It is the structural schematic diagram of an embodiment of the sample analyzer of the present application.
[0022] Among them: the sample injection assembly 101, the injector 1011, the gripper 1012, the relay assembly 1013, the detection assembly 102, the heating assembly 103, the vibration assembly 104, the sampling assembly 105, the alignment assembly 106, the sample analyzer 30, and the sample detection device 1. Detailed implementation manners
[0023] Next, with reference to the accompanying drawings and embodiments, the present application will be further described in detail. It should be specifically noted that the following embodiments are only used to illustrate the present application, but do not limit the scope of the present application. Similarly, the following embodiments are only partial embodiments of the present application rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present application.
[0024] Referring to "embodiment" in this article means that the specific features, structures or characteristics described in combination with the embodiment may be included in at least one embodiment of the present application. The appearance of this phrase in various positions in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. Those skilled in the art will explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.
[0025] In the description of the present application, it should be noted that unless otherwise clearly specified and limited, the terms "installed", "set", "connected", and "coupled" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to specific situations.
[0026] The present application first proposes a sample detection device. Refer to Figure 1 , Figure 1 It is the axonometric schematic diagram of an embodiment of the sample detection device of the present application. As Figure 1 shown, it is the sample detection device 1.
[0027] Refer to Figure 2 and Figure 3 , Figure 2One of the schematic structural diagrams of an embodiment of the sample detection device of the present application Figure 3 Another schematic structural diagram of an embodiment of the sample detection device of the present application, as Figure 2 and Figure 3 shown, the sample detection device includes a sample injection assembly 101, a sampling assembly 105, a heating assembly 103, and a control assembly (not shown in the figure).
[0028] The sample injection assembly 101 is used to move the test tube containing the sample. Among them, the sample injection assembly 101 can specifically be a test tube rack, and test tubes containing various samples can be placed on the test tube rack. For example, the first test tube containing the first sample, or test tubes containing other samples, are not limited herein.
[0029] The sampling assembly 105 is used to collect the sample in the test tube and transport it to the detection assembly 102, so that the detection assembly 102 can perform sample detection on the corresponding sample. Among them, the detection assembly 102 can specifically be an impedance cell, a flow chamber, or other types of components with sample detection functions, which are not limited herein.
[0030] The heating assembly 103 is used to heat the corresponding test tube. Among them, the heating assembly 103 can have a test tube heating slot, and the test tube heating slot can be used for the test tube that needs to be heated to be inserted for heating.
[0031] The control assembly is used for:
[0032] Controlling the sample injection assembly 101 to move the first test tube containing the first sample to the sampling assembly 105.
[0033] Controlling the sampling assembly 105 to collect the first sample in the first test tube and transport it to the detection assembly 102, so that the detection assembly 102 can perform sample detection on the first sample to obtain the first detection result.
[0034] In response to the abnormality of the first detection result, controlling the sample injection assembly 101 to move the first test tube to the heating assembly 103.
[0035] Controlling the heating assembly 103 to heat the first test tube.
[0036] Controlling the sample injection assembly 101 to move the heated first test tube to the sampling assembly 105.
[0037] Controlling the sampling assembly 105 to collect the first sample in the first test tube and transport it to the detection assembly 102, so that the detection assembly 102 can perform sample detection on the first sample to obtain the second detection result.
[0038] Specifically, the situation where the first detection result is abnormal can specifically be that the first detection result contains cold agglutination information, or it can contain other abnormal information, which is not limited herein.
[0039] When the first test result is abnormal, the user can be prompted whether to reheat. In response to the heating instruction input by the user, the sampling component 101 can be controlled to move the first test tube to the heating component 103 for heating, and after heating, a sample test can be performed again. The second test result obtained can be regarded as the final test result for corresponding processing and analysis.
[0040] Based on the above method, the possibility of the first sample being abnormal (such as too low temperature) due to the first test tube waiting for too long can be reduced, thereby avoiding the situation where the abnormal first test result is used as the final test result, and improving the reliability of the sample test.
[0041] Different from the prior art, in the technical solution of the present application, after the sample test of the first sample, the obtained first test result can be analyzed. If the first test result is abnormal, the first test tube can be reheated, and the first sample in the reheated first test tube can be sampled again. The second test result obtained is used as the final test result. Based on the above method, when it is determined that the first test result is abnormal, the first test tube can be reheated, and the first test tube can be sampled again to obtain the second test result, and this is used as the final test result. Based on the above method, when the first sample in the first test tube undergoes abnormal changes due to low temperature because the first test tube waits too long for the sample test, by heating the first sample and sampling the first sample again, a second test result with higher accuracy than the first test result can be obtained as the final test result, improving the reliability of the sample test.
[0042] In one embodiment, as Figure 2 and Figure 3 shown, the sampling component 101 includes a sampler 1011, a gripper 1012, and a relay component 1013.
[0043] Controlling the sampling component 101 to move the first test tube containing the first sample to the sampling component 105 includes:
[0044] Controlling the sampler 1011 to move the first test tube to the gripper 1012.
[0045] Controlling the gripper 1012 to clamp and swing the first test tube, and move the swung first test tube to the relay component 1013.
[0046] Controlling the relay component 1013 to move the first test tube to the sampling component 105.
[0047] In response to the abnormality of the first test result, controlling the sampling component 101 to move the first test tube to the heating component 103 includes:
[0048] In response to the abnormality of the first detection result, the control gripper 1012 moves the first test tube to the heating component 103.
[0049] Controlling the sampling component 101 to move the heated first test tube to the sampling component 105 includes:
[0050] Controlling the gripper 1012 to clamp and swing the first test tube, and moving the heated and swung first test tube to the relay component 1013.
[0051] Controlling the relay component 1013 to move the first test tube to the sampling component 105.
[0052] Specifically, in practice, for example, when the sample detection device is in the whole venous blood test tube mode, it is necessary to perform a whole venous blood test on the first sample in the first test tube. The gripper 1012 can clamp and swing the first test tube to mix the first sample evenly for sample detection to obtain the first detection result.
[0053] After determining that the first detection result is abnormal and heating the first test tube and the first sample therein, the gripper 1012 can also clamp and swing the first test tube to mix the first sample evenly for sample detection to obtain the second detection result.
[0054] Based on the above method, the first test tube can be swung every time before sample detection when the gripper 1012 clamps the first test tube, realizing further mixing treatment before detection and improving the accuracy of subsequent sample detection.
[0055] In one embodiment, as Figure 2 and Figure 3 shown, the sample detection device further includes a vibration component 104.
[0056] The vibration component 104 is used to perform eccentric vibration on the corresponding test tube.
[0057] The control component is further used for:
[0058] Controlling the sampling component 101 to move the second test tube containing the second sample to the vibration component 104. Wherein, the content of the second sample in the second test tube is less than the content of the first sample in the first test tube.
[0059] Controlling the vibration component 104 to perform eccentric vibration on the second test tube.
[0060] Controlling the sampling component 101 to move the vibrated second test tube to the sampling component 105.
[0061] Controlling the sampling component 105 to collect the second sample in the second test tube and transport it to the detection component 102, so that the detection component 102 performs sample detection on the second sample to obtain the third detection result.
[0062] Specifically, in practice, for example, when the sample detection device is in the automatic micro blood tube mode, it is necessary to perform automatic micro blood detection on the second sample in the second tube. Since the second sample in the second tube is a micro blood sample, its content is much smaller than that of the first sample in the first tube. For such samples, it is difficult to achieve thorough mixing by using the swing of the gripper 1012. It is necessary to place the second tube into the vibration assembly 104 to perform eccentric vibration on the second tube, so as to achieve the mixing of the micro blood sample and improve the accuracy of the subsequent obtained third test result.
[0063] In one embodiment, as Figure 2 and Figure 3 shown, the sample detection device includes a mixing assembly, and the mixing assembly includes a heating assembly 103 and a vibration assembly 104. The sampling assembly 101 includes a sampler 1011, a gripper 1012, and a relay assembly 1013.
[0064] The sampler 1011 is used to move the tube containing the sample to the clamping position.
[0065] The gripper 1012 is used to move to the clamping position, clamp the tube from the clamping position, and move the clamped tube to the mixing position or the relay position.
[0066] The mixing assembly is used to move to the mixing position and heat / vibrate the tube at the mixing position.
[0067] The relay assembly 1013 is used to move to the relay position, so that the gripper 1012 moves the tube onto the relay assembly 1013 and moves the tube to the sampling position.
[0068] The sampling assembly 105 is used to move to the sampling position, collect the sample from the tube at the sampling position, and transport the collected sample to the detection assembly 102 for sample detection.
[0069] Specifically, the sampler 1011 may specifically be a test tube rack for placing test tubes storing various samples, and can be used to move the tube containing the sample (such as the first tube, the second tube, or the third tube) to the clamping position. The clamping position can be located below the initial position of the gripper 1012, and the gripper 1012 can move downward to the clamping position to clamp the corresponding tube.
[0070] The mixing position may specifically include the heating position of the heating assembly 103 and the vibration position of the vibration assembly 104 in the mixing assembly. By placing the corresponding tube at the mixing position, corresponding heating and vibration can be performed to achieve mixing. In one example, the mixing position and the relay position can be on the same horizontal plane.
[0071] The gripper 1012 can transfer the test tube at the mixing position to the relay position for the relay component 1013 to move the test tube to the sampling position. The sampling position can be located below the initial position of the sampling component 105. The sampling needle of the sampling component 105 can move downward to sample the sample in the test tube at the sampling position.
[0072] The sampling component 105 can transport the collected sample to at least one detection component 102 for detection to obtain the sample detection result.
[0073] Optionally, the sample detection device may further include a straightening component 106. The initial position of the straightening component 106 is outside the movement range of the relay component 1013, and the straightening position of the straightening component 106 is within the movement range of the relay component 1013. When moving to the straightening position, the straightening component 106 can detect whether there is a test tube on the relay component 1013 (such as optocoupler detection) and can straighten the test tube at the sampling position to ensure that the sampling needle can enter the test tube for sampling, improving the reliability of the sample detection device.
[0074] The straightening component 106 can achieve self-check by moving from the initial position of the straightening component 106 to the straightening position of the straightening component 106 and then moving from the straightening position of the straightening component 106 to the initial position of the straightening component 106.
[0075] Optionally, before controlling the sample injection component 101 to move the test tube containing the sample, the control component is further configured to:
[0076] In response to the sampling component 105 not being in the first initial position, control the sampling component 105 to move to the first initial position. The sampling component 105 is used to move between the first initial position and the sampling position.
[0077] In response to the mixing component not being in the second initial position, control the mixing component to move to the second initial position. The mixing component is used to move between the second initial position and the mixing position.
[0078] In response to the relay component 1013 not being in the third initial position, control the relay component 1013 to move to the third initial position. The relay component 1013 is used to move between the relay position and the sampling position, and the third initial position is located between the relay position and the sampling position.
[0079] Control the gripper 1012 to perform a self-check movement action and control the gripper 1012 to perform clamping and releasing actions to achieve self-check.
[0080] Specifically, such as Figure 2 and Figure 3As shown, the first initial position of the sampling component 105 can be located above the sampling position, the second initial position of the mixing component can be located in the Y direction of the mixing position, and the relay position can be located in the X direction of the sampling position. The X direction and the Y direction are horizontal directions with different directions.
[0081] Before performing the self-check movement action on the gripper 1012, it can be determined whether the sampling component 105 is at its first initial position. If the sampling component 105 is not at its first initial position, the sampling component 105 is controlled to move from its current position to the first initial position to prevent the sampling component 105 from forming an obstructive obstacle during the self-check movement action of the gripper 1012.
[0082] If there is a straightening component 106 as described in the previous embodiment, it is also determined whether the straightening component 106 is at its initial position. If the straightening component 106 is not at its initial position, the straightening component 106 is controlled to move to its initial position to prevent the straightening component 106 from forming an obstructive obstacle during the self-check movement action of the gripper 1012.
[0083] It can be determined whether the mixing component is at its second initial position. If the mixing component is not at its second initial position, the mixing component is controlled to move from its current position to the second initial position to prevent the mixing component from forming an obstructive obstacle during the self-check movement action of the gripper 1012.
[0084] It can be determined whether the relay component 1013 is at its third initial position. If the relay component 1013 is not at its third initial position, the relay component 1013 is controlled to move from its current position to the third initial position to prevent the relay component 1013 from forming an obstructive obstacle during the self-check movement action of the gripper 1012. The third initial position can specifically be located at the midpoint of the movement range of the relay component 1013 in the X direction and at the farthest point of the movement range of the relay component 1013 in the Y direction.
[0085] After completing the avoidance processing of other components outside the gripper 1012 in the above order, the gripper can be controlled to perform the self-check movement action, and the gripper 1012 can be controlled to perform the clamping and releasing actions to determine whether there is a fault, thereby realizing the self-check. If there is a fault, a corresponding warning can be output to notify the corresponding maintenance personnel for maintenance, improving the reliability of the sample detection device.
[0086] It should be noted that the self-check movement action can specifically be to control the gripper to move between its fourth initial position and its clamping position. The actions of the gripper 1012 performing the clamping and releasing actions can specifically be to perform all possible switching or ventilation processes on each solenoid valve and ventilation channel in the pneumatic gripper to detect whether it can be used normally, which is not limited herein.
[0087] Optionally, before controlling the sample injection component 101 to move the test tube containing the sample, the control component is further configured to:
[0088] In response to the gripper 1012 not being in the fourth initial position, control the gripper 1012 to move to the fourth initial position. The gripper 1012 is used to move between the fourth initial position, the mixing position, and the relay position, and the fourth initial position is above the mixing position or the relay position.
[0089] Control the mixing assembly to perform a self-check movement action to achieve self-check.
[0090] Specifically, as Figure 2 and Figure 3 shown, the first initial position of the sampling assembly 105 can be located above the sampling position, the second initial position of the mixing assembly can be located in the Y direction of the mixing position, the relay position can be located in the X direction of the sampling position, and the X direction and the Y direction are horizontal directions with different directions.
[0091] Before performing the self-check movement action on the mixing assembly, it can be determined whether the gripper 1012 is located at its fourth initial position. If the gripper 1012 is not at its fourth initial position, control the gripper 1012 to move from its current position to the fourth initial position to avoid the gripper 1012 forming an obstructive obstacle during the self-check movement action of the mixing assembly.
[0092] After completing the avoidance processing of other components outside the mixing assembly in the above manner, the mixing assembly can be controlled to perform a self-check movement action to determine whether there is a fault and achieve self-check. If there is a fault, a corresponding warning can be output to notify the corresponding maintenance personnel for maintenance, improving the reliability of the sample detection device.
[0093] It should be noted that the self-check movement action can specifically be to control the mixing assembly to move between its second initial position and the mixing position to detect whether it can be used normally, which is not limited here.
[0094] Optionally, before controlling the sampling component 101 to move the test tube containing the sample, the control component is further used for:
[0095] In response to the gripper 1012 not being in the fourth initial position, control the gripper 1012 to move to the fourth initial position. The gripper 1012 is used to move between the fourth initial position, the mixing position, and the relay position, and the fourth initial position is above the mixing position or the relay position.
[0096] In response to the sampling assembly 105 not being in the first initial position, control the sampling assembly 105 to move to the first initial position. The sampling assembly 105 is used to move between the first initial position and the sampling position.
[0097] In response to the mixing assembly not being in the second initial position, control the mixing assembly to move to the second initial position. The mixing assembly is used to move between the second initial position and the mixing position.
[0098] The control relay component 1013 performs a self-check movement action to achieve self-checking.
[0099] Specifically, as Figure 2 and Figure 3 shown, the first initial position of the sampling component 105 can be located above the sampling position, the second initial position of the mixing component can be located in the Y direction of the mixing position, the relay position can be located in the X direction of the sampling position, and the X direction and the Y direction are horizontal directions with different directions.
[0100] Before performing the self-check movement action on the relay component 1013, it can be determined whether the gripper 1012 is at its fourth initial position. If the gripper 1012 is not at its fourth initial position, then control the gripper 1012 to move from its current position to the fourth initial position to avoid the gripper 1012 forming an obstructive obstacle during the self-check movement action of the relay component 1013.
[0101] It can be determined whether the sampling component 105 is at its first initial position. If the sampling component 105 is not at its first initial position, then control the sampling component 105 to move from its current position to the first initial position to avoid the sampling component 105 forming an obstructive obstacle during the self-check movement action of the relay component 1013.
[0102] It can be determined whether the mixing component is at its second initial position. If the mixing component is not at its second initial position, then control the mixing component to move from its current position to the second initial position to avoid the mixing component forming an obstructive obstacle during the self-check movement action of the relay component 1013.
[0103] After completing the avoidance processing of other components outside the relay component 1013 in the above order, the relay component 1013 can be controlled to perform a self-check movement action to determine whether there is a fault, thereby achieving self-checking. If there is a fault, a corresponding warning can be output to notify the corresponding maintenance personnel for maintenance, improving the reliability of the sample detection device.
[0104] It should be noted that the self-check movement action can specifically be to control the relay component 1013 to move in the X direction and the Y direction. For example, the relay component 1013 can be first controlled to move in the Y direction to the nearest point, which is the relay puncture position of the relay component 1013 and is the position for the corresponding sampling needle to perform puncture sampling on the test tube. When the relay component 1013 moves in the Y direction to the relay puncture position, control the relay component 1013 to move to multiple positions (such as the closed injection puncture position, the automatic injection puncture position, the closed out-warehouse position, and other types of custom positions) in the X direction to determine whether there is a fault or other abnormal conditions during the process, thereby achieving self-checking. Finally, the relay component 1013 can be controlled to move back to its third initial position.
[0105] Optionally, before controlling the sample injection component 101 to move the test tube containing the sample, the control component is further configured to:
[0106] In response to the gripper 1012 not being in the fourth initial position, control the gripper 1012 to move to the fourth initial position. The gripper 1012 is used to move between the fourth initial position, the mixing position, and the relay position, and the fourth initial position is above the mixing position or the relay position.
[0107] In response to the mixing component not being in the second initial position, control the mixing component to move to the second initial position. The mixing component is used to move between the second initial position and the mixing position.
[0108] In response to the sampling component 105 not being in the first initial position, control the sampling component 105 to move to the first initial position. The sampling component 105 is used to move between the first initial position and the sampling position. Before the relay component 1013 returns to the initial position, by controlling the sampling component 105 to return to the initial position, it is possible to avoid the situation where the sampling needle of the sampling component 105 is still in the test tube on the relay component 1013, thereby reducing the possibility of the sampling needle breaking or other unexpected situations and improving safety.
[0109] In response to the relay component 1013 not being in the third initial position, control the relay component 1013 to move to the third initial position. The relay component 1013 is used to move between the relay position and the sampling position, and the third initial position is located between the relay position and the sampling position.
[0110] Control the sampling component 105 to perform a self-check moving action.
[0111] Specifically, as Figure 2 and Figure 3 shown, the first initial position of the sampling component 105 can be located above the sampling position, the second initial position of the mixing component can be located in the Y direction of the mixing position, the relay position can be located in the X direction of the sampling position, and the X direction and the Y direction are horizontal directions with different directions.
[0112] Before performing the self-check moving action on the sampling component 105, it can be determined whether the gripper 1012 is in its fourth initial position. If the gripper 1012 is not in its fourth initial position, then control the gripper 1012 to move from its current position to the fourth initial position to avoid the gripper 1012 forming an obstructive obstacle during the self-check moving action of the sampling component 105.
[0113] It can be determined whether the mixing component is in its second initial position. If the mixing component is not in its second initial position, then control the mixing component to move from its current position to the second initial position to avoid the mixing component forming an obstructive obstacle during the self-check moving action of the sampling component 105.
[0114] It is possible to determine whether the sampling component 105 is in its first initial position. If the sampling component 105 is not in its first initial position, the sampling component 105 is controlled to move from its current position to the first initial position, so as to prevent the sampling component 105 from forming an obstructive obstacle during the subsequent movement of the relay component 1013 to its third initial position.
[0115] It is possible to determine whether the relay component 1013 is in its third initial position. If the relay component 1013 is not in its third initial position, the relay component 1013 is controlled to move from its current position to the third initial position, so as to prevent the relay component 1013 from forming an obstructive obstacle during the self-check movement of the gripper 1012. Specifically, the third initial position can be located at the midpoint of the movement range of the relay component 1013 in the X direction and at the farthest point of the movement range of the relay component 1013 in the Y direction.
[0116] After completing the avoidance processing of other components outside the sampling component 105 in the above order, the sampling component 105 can be controlled to perform a self-check movement to determine whether there is a fault, thereby realizing self-check. If there is a fault, a corresponding warning can be output to notify the corresponding maintenance personnel for maintenance, improving the reliability of the sample detection device.
[0117] It should be noted that the self-check movement can specifically be to first control the sampling component 105 to move to the highest point in the vertical direction and at the nearest point in the Y direction, that is, to first control the sampling component 105 to move to its first initial position.
[0118] Then, the sampling needle of the sampling component 105 is controlled to perform downward sampling and upward restoration actions in the vertical direction to determine whether there is a fault with the sampling needle.
[0119] Then, the sampling component 105 is controlled to move to multiple positions in the Y direction (such as at least one of the cleaning liquid level, CRP R2 reagent bottle position, SAA R2 reagent bottle position, RBC / HGB reaction pool position, CRP reaction pool 1 position, CRP reaction pool 2 position, SAA reaction pool 1 position, SAA reaction pool 2 position, WPC reaction pool position, WDF reaction pool position, WNR reaction pool position, RET reaction pool position, and the positions of other custom reagent bottles or reaction pools) to determine whether there is a fault or other abnormal conditions during the process, realizing self-check. Finally, the sampling component 105 can be controlled to move back to its first initial position.
[0120] At least one of the above-mentioned multiple positions (such as the cleaning liquid level, the CRP R2 reagent bottle position, the SAA R2 reagent bottle position, the RBC / HGB reaction cell position, the CRP reaction cell 1 position, the CRP reaction cell 2 position, the SAA reaction cell 1 position, the SAA reaction cell 2 position, the WPC reaction cell position, the WDF reaction cell position, the WNR reaction cell position, the RET reaction cell position, and the positions of other custom reagent bottles or reaction cells) can specifically be the positions of the respective reagent bottles or reaction cells in the detection assembly 102. The sampling assembly 105 injects the sample in the collected test tube and the reagent in the collected reagent bottle into the corresponding reaction cells respectively to achieve sample detection and obtain a detection result.
[0121] In summary, by performing corresponding self-checks on each component in the sample detection device before controlling the sample injection assembly 101 to move the test tube containing the sample, that is, before performing sample detection or its preparation operations, it is possible to ensure that there are no faults in each component before each sample detection, reducing the possibility of sample detection failure due to component faults during subsequent sample detection, thereby reducing the possibility of sample or reagent waste and further improving the reliability of the sample detection device.
[0122] This application proposes a sample detection method, which can be applied to the sample detection device described in any of the previous embodiments. Refer to Figure 4 , Figure 4 which is a schematic flowchart of an embodiment of the sample detection method of this application. The sample detection method can specifically be the steps executed by the control component mentioned above.
[0123] As Figure 4 shown, the sample detection method includes:
[0124] Step S21: Control the sample injection assembly 101 to move the first test tube containing the first sample to the sampling assembly 105.
[0125] Step S22: Control the sampling assembly 105 to collect the first sample in the first test tube and transport it to the detection assembly 102, so that the detection assembly 102 performs sample detection on the first sample to obtain a first detection result.
[0126] Step S23: In response to an abnormal first detection result, control the sample injection assembly 101 to move the first test tube to the heating assembly 103.
[0127] Step S24: Control the heating assembly 103 to heat the first test tube.
[0128] Step S25: Control the sample injection assembly 101 to move the heated first test tube to the sampling assembly 105.
[0129] Step S26: Control the sampling component 105 to collect the first sample in the first test tube and transport it to the detection component 102, so that the detection component 102 performs sample detection on the first sample to obtain a second detection result.
[0130] Specifically, the sample detection method may further include other steps performed by the control component, which will not be elaborated here.
[0131] Different from the prior art, in the technical solution of this application, after performing sample detection on the first sample, the obtained first detection result can be analyzed. If the first detection result is abnormal, the first test tube can be reheated, and the first sample in the reheated first test tube can be subjected to sample detection again. The obtained second detection result is used as the final detection result. Based on the above method, when it is determined that the first detection result is abnormal, the first test tube can be reheated, and the first test tube can be subjected to sample detection again to obtain a second detection result, which is used as the final detection result. Based on the above method, when the first sample in the first test tube undergoes abnormal changes due to low temperature because the waiting time for sample detection is too long, by heating the first sample and performing sample detection on the first sample again, a second detection result with higher accuracy than the first detection result can be obtained as the final detection result, improving the reliability of sample detection.
[0132] This application proposes a sample analyzer. Refer to Figure 5 , Figure 5 which is a schematic structural diagram of an embodiment of the sample analyzer of this application. As Figure 5 shown, the sample analyzer 30 includes a sample detection device 1. The sample detection device 1 can specifically be the sample detection device described in any of the previous embodiments, which will not be elaborated here.
[0133] Different from the prior art, in the technical solution of this application, after performing sample detection on the first sample, the obtained first detection result can be analyzed. If the first detection result is abnormal, the first test tube can be reheated, and the first sample in the reheated first test tube can be subjected to sample detection again. The obtained second detection result is used as the final detection result. Based on the above method, when it is determined that the first detection result is abnormal, the first test tube can be reheated, and the first test tube can be subjected to sample detection again to obtain a second detection result, which is used as the final detection result. Based on the above method, when the first sample in the first test tube undergoes abnormal changes due to low temperature because the waiting time for sample detection is too long, by heating the first sample and performing sample detection on the first sample again, a second detection result with higher accuracy than the first detection result can be obtained as the final detection result, improving the reliability of sample detection.
[0134] In the description of the present application, the descriptions with reference to terms such as "one embodiment", "some embodiments", "examples", "specific examples", or "some examples", etc. mean that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.
[0135] In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of the features. In the description of the present application, "a plurality of" means at least two, such as two, three, etc., unless otherwise specifically defined.
[0136] Any process or method description shown in the flowchart or described in other ways herein can be understood as representing a module, segment, or part of code including one or more executable instructions for implementing a specific logical function or process. And the scope of the preferred embodiments of the present application includes additional implementations, where the functions can be executed in a substantially simultaneous manner or in the reverse order according to the functions involved, rather than in the order shown or discussed, which should be understood by those skilled in the art to which the embodiments of the present application pertain.
[0137] The logic and / or steps represented in the flowchart or otherwise described herein can be considered, for example, a definitional sequence of executable instructions for implementing a logical function, which can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device (which can be a personal computer, server, network device, or other system that can fetch instructions from and execute instructions by the instruction execution system, apparatus, or device). For the purposes of this specification, a "computer-readable medium" can be any device that can contain, store, communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. More specific examples (non-exhaustive list) of the computer-readable medium include the following: an electrical connection portion (electronic device) having one or more wirings, a portable computer diskette (magnetic device), a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium can even be paper or other suitable medium on which the program can be printed, as the program can be obtained electronically, for example, by optically scanning the paper or other medium, followed by editing, interpretation, or otherwise appropriate processing if necessary, and then storing it in a computer memory.
[0138] The above are only the embodiments of the present application, and do not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made by using the content of the specification and drawings of the present application, or directly or indirectly applied in other related technical fields, shall be equally included in the patent protection scope of the present application.
Claims
1. A sample detection device, characterized in that, it includes: a sample injection component for moving a test tube containing a sample; a sampling component for collecting the sample in the test tube and transporting it to a detection component, and the detection component is used to perform sample detection on the corresponding sample; a heating component for heating the corresponding test tube; a control component for: controlling the sample injection component to move a first test tube containing a first sample to the sampling component; controlling the sampling component to collect the first sample in the first test tube and transport it to the detection component, so that the detection component performs sample detection on the first sample to obtain a first detection result; in response to the abnormality of the first detection result, controlling the sample injection component to move the first test tube to the heating component; controlling the heating component to heat the first test tube; controlling the sample injection component to move the heated first test tube to the sampling component; controlling the sampling component to collect the first sample in the first test tube and transport it to the detection component, so that the detection component performs sample detection on the first sample to obtain a second detection result.
2. The sample detection device according to claim 1, characterized in that, the sample injection component includes an injector, a gripper and a relay component; the controlling the sample injection component to move a first test tube containing a first sample to the sampling component includes: controlling the injector to move the first test tube to the gripper; controlling the gripper to clamp and swing the first test tube, and move the swung first test tube to the relay component; controlling the relay component to move the first test tube to the sampling component; the in response to the abnormality of the first detection result, controlling the sample injection component to move the first test tube to the heating component includes: in response to the abnormality of the first detection result, controlling the gripper to move the first test tube to the heating component; the controlling the sample injection component to move the heated first test tube to the sampling component includes: controlling the gripper to clamp and swing the first test tube, and move the heated and swung first test tube to the relay component; controlling the relay component to move the first test tube to the sampling component.
3. The sample detection device according to claim 1 or 2, characterized in that, the sample detection device further includes: a vibration component for performing eccentric vibration on the corresponding test tube; the control component is further used for: controlling the sample injection component to move a second test tube containing a second sample to the vibration component; wherein, the content of the second sample in the second test tube is less than the content of the first sample in the first test tube; controlling the vibration component to perform eccentric vibration on the second test tube; controlling the sample injection component to move the vibrated second test tube to the sampling component; Control the sampling component to collect the second sample in the second test tube and transport it to the detection component, so that the detection component performs sample detection on the second sample to obtain a third detection result.
4. The sample detection device according to claim 1 or 2, wherein, the sample detection device includes a mixing component, the mixing component includes the heating component and the vibration component, and the sample injection component includes a syringe, a gripper and a relay component; the syringe is used to move the test tube containing the sample to the clamping position; the gripper is used to move to the clamping position, clamp the test tube from the clamping position, and move the clamped test tube to the mixing position or the relay position; the mixing component is used to move to the mixing position and heat or vibrate the test tube at the mixing position; the relay component is used to move to the relay position, so that the gripper moves the test tube onto the relay component and moves the test tube to the sampling position; the sampling component is used to move to the sampling position, collect the sample from the test tube at the sampling position, and transport the collected sample to the detection component for sample detection.
5. The sample detection device according to claim 4, wherein, before controlling the sample injection component to move the test tube containing the sample, the control component is further used for: in response to the sampling component not being in the first initial position, controlling the sampling component to move to the first initial position; wherein, the sampling component is used to move between the first initial position and the sampling position; in response to the mixing component not being in the second initial position, controlling the mixing component to move to the second initial position; wherein, the mixing component is used to move between the second initial position and the mixing position; in response to the relay component not being in the third initial position, controlling the relay component to move to the third initial position; wherein, the relay component is used to move between the relay position and the sampling position, and the third initial position is located between the relay position and the sampling position; controlling the gripper to perform a self-check moving action and controlling the gripper to perform clamping and releasing actions to achieve self-check.
6. The sample detection device according to claim 4, wherein, before controlling the sample injection component to move the test tube containing the sample, the control component is further used for: in response to the gripper not being in the fourth initial position, controlling the gripper to move to the fourth initial position; wherein, the gripper is used to move between the fourth initial position, the mixing position and the relay position, and the fourth initial position is above the mixing position or the relay position; controlling the mixing component to perform a self-check moving action to achieve self-check.
7. The sample detection device according to claim 4, wherein, before controlling the sample injection component to move the test tube containing the sample, the control component is further used for: in response to the gripper not being in the fourth initial position, controlling the gripper to move to the fourth initial position; wherein, the gripper is used to move between the fourth initial position, the mixing position and the relay position, and the fourth initial position is above the mixing position or the relay position; In response to the sampling component not being in the first initial position, control the sampling component to move to the first initial position; wherein, the sampling component is used to move between the first initial position and the sampling position; In response to the mixing component not being in the second initial position, control the mixing component to move to the second initial position; wherein, the mixing component is used to move between the second initial position and the mixing position; Control the relay component to perform a self-check movement action to achieve self-check.
8. The sample detection device according to claim 4, wherein, Before controlling the sample injection component to move the test tube containing the sample, the control component is further configured to: In response to the gripper not being in the fourth initial position, control the gripper to move to the fourth initial position; wherein, the gripper is used to move between the fourth initial position, the mixing position, and the relay position, and the fourth initial position is above the mixing position or the relay position; In response to the mixing component not being in the second initial position, control the mixing component to move to the second initial position; wherein, the mixing component is used to move between the second initial position and the mixing position; In response to the sampling component not being in the first initial position, control the sampling component to move to the first initial position; wherein, the sampling component is used to move between the first initial position and the sampling position; In response to the relay component not being in the third initial position, control the relay component to move to the third initial position; wherein, the relay component is used to move between the relay position and the sampling position, and the third initial position is located between the relay position and the sampling position; Control the sampling component to perform a self-check movement action.
9. A sample detection method, wherein, applied to the sample detection device according to any one of claims 1 to 8; the sample detection method includes: Control the sample injection component to move the first test tube containing the first sample to the sampling component; Control the sampling component to collect the first sample in the first test tube and transport it to the detection component, so that the detection component performs sample detection on the first sample to obtain a first detection result; In response to the first detection result being abnormal, control the sample injection component to move the first test tube to the heating component; Control the heating component to heat the first test tube; Control the sample injection component to move the heated first test tube to the sampling component; Control the sampling component to collect the first sample in the first test tube and transport it to the detection component, so that the detection component performs sample detection on the first sample to obtain a second detection result.
10. A sample analyzer, wherein, comprises the sample detection device according to any one of claims 1 to 8.