Sample detection device and sample analyzer

Abstract

The invention discloses a sample detection device and a sample analyzer. The sample detection device comprises a reaction tank; the dye liquor assembly is used for storing dye liquor, and the dye liquor assembly is arranged adjacent to the reaction tank; the sample assembly is used for storing samples; the sampling assembly comprises a sampling needle; a detection assembly; the control assembly is used for controlling the sampling needle to collect a sample from the sample assembly; controlling the sampling needle to inject the sample into the reaction tank; controlling the sampling needle to clean; controlling the sampling needle to collect the dye liquor from the dye liquor assembly; controlling the sampling needle to inject the dye liquor into the reaction tank to obtain sample liquor; and controlling the detection assembly to perform sample detection on the sample liquid to obtain a detection result. Based on the mode, the utilization rate of the dye liquor can be improved.

Description

Technical Field

[0001] This application relates to the field of detection technology, in particular to a sample detection device and a sample analyzer. Background Art

[0002] In the prior art, a reaction pool is usually equipped with a metering pump and a dye solution bottle. The metering pump is respectively connected to the reaction pool and the dye solution bottle. The metering pump can suck the dye solution from the dye solution bottle and spit the sucked dye solution into the reaction pool. In addition, a sampling needle is controlled to inject a sample into the reaction pool, so that the sample, the dye solution and the diluent in the reaction pool are mixed evenly to obtain a sample solution for subsequent sample detection.

[0003] The defect of the prior art is that since the delivery pipeline of the dye solution is directly connected to the reaction pool, when standing still, there will inevitably be a phenomenon of dye solution diffusion between the delivery pipeline of the dye solution and the reaction pool. The current treatment method is usually to discard a part of the contaminated dye solution in the delivery pipeline of the dye solution that is relatively close to the reaction pool before injecting the sample, the diluent and the dye solution into the reaction pool. That is, additional dye solution needs to be consumed in sample detection, resulting in low utilization rate of the dye solution. Summary of the Invention

[0004] The main technical problem to be solved by this application is how to improve the utilization rate of the dye solution.

[0005] To solve the above technical problem, the first technical solution adopted by this application is: a sample detection device, including: a reaction pool; a dye solution assembly for storing the dye solution, the dye solution assembly is arranged adjacent to the reaction pool; a sample assembly for storing the sample; a sampling assembly including a sampling needle; a detection assembly; a control assembly for: controlling the sampling needle to collect the sample from the sample assembly; controlling the sampling needle to inject the sample into the reaction pool; controlling the sampling needle to be cleaned; controlling the sampling needle to collect the dye solution from the dye solution assembly; controlling the sampling needle to inject the dye solution into the reaction pool to obtain a sample solution; controlling the detection assembly to perform sample detection on the sample solution to obtain a detection result.

[0006] Wherein, the sample detection device further includes: a first three-way valve, the first branch of the first three-way valve is connected to the reaction pool; a reaction reagent assembly connected to the second branch of the first three-way valve; a first suction and spit assembly connected to the common port of the first three-way valve; the control assembly is further used for: controlling the first three-way valve to conduct its second branch and its common port; controlling the first suction and spit assembly to suck the reaction reagent from the reaction reagent assembly; controlling the first three-way valve to conduct its first branch and its common port; controlling the first suction and spit assembly to spit the reaction reagent into the reaction pool and controlling the sampling needle to inject the sample into the reaction pool.

[0007] Among them, the control component is further configured to: control the first suction and ejection component to eject a first preset amount of reaction reagent into the reaction pool, and control the sampling needle to inject a sample into the reaction pool; control the sampling needle to inject a staining solution into the reaction pool to obtain a sample solution, including: control the first suction and ejection component to eject a second preset amount of reaction reagent into the above-mentioned reaction pool, and control the sampling needle to inject a staining solution into the reaction pool to obtain a sample solution.

[0008] Among them, the control component is further configured to: control the first suction and ejection component to eject a third preset amount of reaction reagent into the above-mentioned reaction pool, and control the sampling needle to inject a sample into the reaction pool; control the sampling needle to inject a staining solution into the reaction pool, and control the sampling needle to mix the liquid in the reaction pool to obtain a sample solution.

[0009] Among them, the control component is further configured to: control the needle rod of the sampling needle to stir in the liquid in the reaction pool, and / or control the sampling needle to perform multiple suction and ejection operations in the liquid in the reaction pool.

[0010] Among them, controlling the sampling needle to be cleaned includes: controlling the sampling needle to move to the staining solution component, and controlling the sampling needle to be cleaned during the movement.

[0011] Among them, the control component is further configured to: control the sampling needle to move to the staining solution component, and control the sampling needle to be cleaned during the movement, and complete the cleaning of the sampling needle before the sampling needle reaches the staining solution component.

[0012] Among them, the sample detection device further includes: a cleaning solution component for storing a cleaning solution; a waste liquid component for storing waste liquid; a first switching valve; a cleaning swab having a first accommodating cavity, the cleaning swab is sleeved on the outer wall of the sampling needle so that at least a part of the outer wall of the sampling needle is located in the first accommodating cavity, a first opening of the cleaning swab is connected to one end of the first switching valve, the other end of the first switching valve is connected to the cleaning solution component, and a second opening of the cleaning swab is connected to the waste liquid component; the control component is further configured to: control the first switching valve to open, and control a relative movement along the outer wall of the sampling needle between the cleaning swab and the sampling needle.

[0013] Among them, the sample detection device further includes: a second switching valve; the sampling component further includes a syringe having a second accommodating cavity, a first opening of the syringe is connected to the tail of the sampling needle, a second opening of the syringe is connected to one end of the second switching valve, and the other end of the second switching valve is connected to the cleaning solution component; the control component is further configured to: control the cleaning swab to move so that the needle opening of the sampling needle is located in the first accommodating cavity, and control the second switching valve to open.

[0014] To solve the above technical problems, the second technical solution adopted by this application is: a sample detection method applied to the sample detection device as described above, and the method is used for:

[0015] Control the sampling needle to collect a sample from the sample assembly;

[0016] Control the sampling needle to inject the sample into the reaction cell;

[0017] Control the sampling needle to be cleaned;

[0018] Control the sampling needle to collect a dye solution from the dye solution assembly;

[0019] Control the sampling needle to inject the dye solution into the reaction cell to obtain a sample solution;

[0020] Control the detection assembly to perform sample detection on the sample solution to obtain a detection result.

[0021] The beneficial effects of this application are as follows: Different from the prior art, in the technical solution of this application, the sample detection device includes a reaction cell, a dye solution assembly, a sample assembly, a sampling assembly, a detection assembly, and a control assembly. The control assembly controls the sampling needle to collect a sample from the sample assembly, controls the sampling needle to inject the sample into the reaction cell, controls the sampling needle to be cleaned, controls the sampling needle to collect a dye solution from the dye solution assembly, controls the sampling needle to inject the dye solution into the reaction cell to obtain a sample solution, and controls the detection assembly to perform sample detection on the sample solution to obtain a detection result. Based on the above method, the dye solution assembly and the reaction cell can be separately arranged independently of each other. Since there is no fixed connecting pipeline between the dye solution assembly and the reaction cell, and the dye solution is added to the reaction cell by extracting and injecting the dye solution from the dye solution assembly through the sampling needle, the situation of dye solution diffusion caused by long-term static placement between the dye solution assembly and the reaction cell can be avoided. Furthermore, the need to discard the contaminated dye solution due to dye solution diffusion is avoided, reducing the additional consumption of the dye solution and improving the utilization rate of the dye solution. Description of the Drawings

[0022] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0023] Figure 1 It is a schematic structural diagram of an embodiment of the sample detection device of this application.

[0024] Wherein: reaction tank 101, dye solution assembly 102, sample assembly 103, sampling assembly 104, sampling needle 1041, syringe 1042, detection assembly 105, first three-way valve 106, diluent assembly 107, first suction and discharge assembly 108, cleaning solution assembly 109, waste liquid assembly 110, first switching valve 111 and cleaning swab 112, second switching valve 113, third switching valve 114, fourth switching valve 115, fifth switching valve 116, sample detection device 21. Detailed implementation manners

[0025] The present application will be further described in detail below with reference to the accompanying drawings and embodiments. It should be specifically noted that the following embodiments are only used to illustrate the present application, but do not limit the scope of the present application. Similarly, the following embodiments are only partial embodiments of the present application rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present application.

[0026] Referring to "embodiments" herein means that specific features, structures, or characteristics described in connection with the embodiments can be included in at least one embodiment of the present application. The phrase appears in various places in the specification and does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. Those skilled in the art will explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.

[0027] In the description of the present application, it should be noted that unless otherwise clearly specified and limited, the terms "installed", "set", "connected", and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0028] With the continuous development of basic medicine and medical technology, the detection principles of sample analyzers (such as blood analyzers) have become increasingly precise and diverse, the detection technology has been continuously innovated, and the detection parameters have increased significantly. "High precision, high speed, easy operation, and strong functions" are the strong advantages of modern blood analyzers.

[0029] For example, looking at hematology analyzers from different manufacturers on the market, hematology analyzers using the "nucleic acid fluorescence staining" detection principle are the mainstream and model among many blood cell brands. For example, a five-part differential hematology analyzer uses a specific nucleic acid fluorescent dye. After the cells are treated with a special hemolysin, the fluorescent dye can quickly enter the cytoplasm and nucleus to stain the nucleic acid. The fluorescent dye in the cell produces a certain fluorescence intensity under the excitation of a laser with a specific wavelength, and this fluorescence intensity is positively correlated with the nucleic acid content of the cell. However, in actual use, due to the water absorption and light condensation characteristics of the nucleic acid fluorescent dye, the capillary guiding method is mostly used in the industry for sampling the dye solution.

[0030] The above-mentioned nucleic acid fluorescent dye is one of the above-mentioned dye solutions, and the dye solution can specifically be a solution that combines and colors the sample through chemical or other effects.

[0031] For example, when performing sample detection and observing and analyzing samples such as blood cells under an optical microscope or under the detection of laser irradiation, since the sample itself is usually transparent, and there are many types of cells with relatively small volumes, in this case, if the sample is not stained, it is very difficult for us to accurately obtain the sample information. Therefore, the sample is usually stained with a dye solution, and then the corresponding sample detection is carried out to obtain more reliable and accurate sample detection results.

[0032] This application first proposes a sample detection device. Refer to Figure 1 , Figure 1 is a schematic structural diagram of an embodiment of the sample detection device of this application. As Figure 1 shown, the sample detection device includes a reaction pool 101, a dye solution component 102, a sample component 103, a sampling component 104, a detection component 105, and a control component (not shown in the figure).

[0033] The dye solution component 102 is used to store the dye solution, and the dye solution component 102 is disposed adjacent to the reaction pool 101. Among them, the dye solution component 102 can specifically be a dye solution bottle or other types of components for storing the dye solution, which is not limited here. By disposing the dye solution component 102 adjacent to the reaction pool 101, the sampling needle can move a short distance after collecting the sample from the dye solution component 102 to reach the reaction pool 101, reducing the possibility that the dye solution volatilizes or deteriorates due to too long moving time in contact with the outside air and improving the reliability of the dye solution.

[0034] The sample component 103 is used to store the sample. Among them, the sample component 103 can specifically be a test tube containing the sample, or a test tube containing the sample and the test tube rack where it is located. The sample can specifically be a blood sample or other types of samples, which is not limited here.

[0035] The sampling assembly 104 includes a sampling needle 1041. Among them, the sampling assembly 104 can control the needle opening of its sampling needle 1041 to move into the dye solution assembly 102 to collect the dye solution, and can also control the needle opening of its sampling needle 1041 to move into the reaction pool 101 to inject the dye solution.

[0036] The control assembly is used for:

[0037] Controlling the sampling needle 1041 to collect a sample from the sample assembly 103.

[0038] Controlling the sampling needle 1041 to inject the sample into the reaction pool 101.

[0039] Controlling the sampling needle 1041 to be cleaned.

[0040] Controlling the sampling needle 1041 to collect the dye solution from the dye solution assembly 102.

[0041] Controlling the sampling needle 1041 to inject the dye solution into the reaction pool 101 to obtain a sample solution.

[0042] Controlling the detection assembly 105 to perform sample detection on the sample solution to obtain a detection result.

[0043] Specifically, in practical applications, the needle opening of the sampling needle 1041 can be controlled to move into the sample assembly 103 and the sampling needle 1041 can be controlled to suck in the sample, and then the needle opening of the sampling needle 1041 can be controlled to leave the sample assembly 103 and move to the reaction pool 101 to inject the sample, and then the inner wall and outer wall of the sampling needle 1041 are cleaned to reduce the possibility of the dye solution in the dye solution assembly 102 being contaminated due to residual samples.

[0044] After the cleaning is completed, the needle opening of the sampling needle 1041 is controlled to move into the dye solution assembly 102 and the sampling needle 1041 is controlled to suck in the dye solution, and then the needle opening of the sampling needle 1041 is controlled to leave the dye solution assembly 102 and move to the reaction pool 101 to inject the dye solution.

[0045] The sample, the dye solution, and the reaction reagent in the reaction pool 101 are mixed evenly to obtain a sample solution, and the sample solution is injected into the detection assembly 105 to perform sample detection on the sample.

[0046] Based on the above method, since the reaction pool 101 and the dye solution assembly 102 are two independent containers and there is no fixed connecting pipeline between them, the sampling needle 1041 is used to suck in, move, and spit out the dye solution to realize the transportation of the dye solution. Therefore, in this sample detection device, there will be no phenomenon of dye solution diffusion between the reaction pool 101 and the dye solution assembly 102 due to long-term static placement. Furthermore, it is not necessary to discard part of the contaminated dye solution before preparing the sample solution each time, reducing the consumption of the dye solution and improving the utilization rate of the dye solution.

[0047] The dye solution can specifically refer to the RET dye solution or other types of dye solutions, which are not limited here.

[0048] The detection component 105 can specifically be an optical detection component, such as a flow cell. After receiving the sample solution, the detection component 105 can perform fluorescence detection or other types of sample detections on the sample to obtain a detection result, which is not limited here.

[0049] Different from the prior art, in the technical solution of this application, the sample detection device includes a reaction pool, a dye solution component, a sample component, a sampling component, a detection component, and a control component. The control component controls the sampling needle to collect a sample from the sample component, controls the sampling needle to inject the sample into the reaction pool, controls the sampling needle to be cleaned, controls the sampling needle to collect the dye solution from the dye solution component, controls the sampling needle to inject the dye solution into the reaction pool to obtain a sample solution, and controls the detection component to perform a sample detection on the sample solution to obtain a detection result. Based on the above method, the dye solution component and the reaction pool can be separately arranged independently of each other. Since there is no fixed connecting pipeline between the dye solution component and the reaction pool, and the dye solution is added to the reaction pool by extracting it from the dye solution component with a sampling needle and injecting it into the reaction pool, the situation of dye solution diffusion caused by long-term static placement between the dye solution component and the reaction pool can be avoided. Furthermore, the need to discard the dye solution contaminated by dye solution diffusion can be avoided, reducing the additional consumption of the dye solution and improving the utilization rate of the dye solution.

[0050] In addition, since the setting of the suction and discharge module (such as a metering pump) and related pipelines required when connecting the dye solution component 102 to the reaction pool 101 is reduced, the complexity of the sample detection device can also be reduced, thereby reducing the maintenance cost and maintenance time of the sample detection device.

[0051] In one embodiment, as Figure 1 shown, the sample detection device further includes a first three-way valve 106, a reaction reagent component, and a first suction and discharge component 108.

[0052] The first branch port of the first three-way valve 106 is connected to the reaction pool 101.

[0053] The reaction reagent component is connected to the second branch port of the first three-way valve 106.

[0054] The first suction and discharge component 108 is connected to the common port of the first three-way valve 106.

[0055] Controlling the sampling needle 1041 to inject the sample into the reaction pool 101 includes:

[0056] Controlling the first three-way valve 106 to conduct its second branch port and its common port.

[0057] Controlling the first suction and discharge component 108 to suck the reaction reagent from the reaction reagent component.

[0058] Control the first three-way valve 106 to conduct its first branch port and its common port.

[0059] Control the first suction and discharge assembly 108 to discharge the reaction reagent into the reaction cell 101 described above, and control the sampling needle 1041 to inject the sample into the reaction cell 101. In this application, the reaction reagent assembly includes, but is not limited to, a diluent assembly 107 and / or a hemolytic agent assembly, and the reaction reagent includes, but is not limited to, a diluent and / or a hemolytic agent. As Figure 1 shown, the reaction reagent assembly is the diluent assembly 107

[0060] Specifically, when controlling the sampling needle 1041 to add the sample to the reaction cell 101, the first three-way valve 106 can be controlled to conduct its first branch port and its common port, and the first suction and discharge assembly 108 can be controlled to synchronously add the diluent previously inhaled from the diluent assembly 107 to the reaction cell 101.

[0061] Based on the above method, by synchronously adding the sample and the diluent to the reaction cell 101, the sample and the diluent can be fully mixed, improving the mixing degree of the manufactured sample solution, and further improving the accuracy of subsequent sample detection based on the sample solution.

[0062] Optionally, controlling the first suction and discharge assembly 108 to discharge the reaction reagent into the reaction cell 101 described above, and controlling the sampling needle 1041 to inject the sample into the reaction cell 101 includes:

[0063] Control the first suction and discharge assembly 108 to discharge a first preset amount of the reaction reagent into the reaction cell 101 described above, and control the sampling needle 1041 to inject the sample into the reaction cell 101.

[0064] Controlling the sampling needle 1041 to inject the staining solution into the reaction cell 101 to obtain the sample solution includes:

[0065] Control the first suction and discharge assembly 108 to discharge a second preset amount of the reaction reagent into the reaction cell 101 described above, and control the sampling needle 1041 to inject the staining solution into the reaction cell 101 to obtain the sample solution.

[0066] Specifically, the reaction reagent can be a diluent, and both the first preset amount of the reaction reagent and the second preset amount of the reaction reagent can be diluents. The diluent can be synchronously added when adding the sample to the reaction cell 101 to improve the mixing efficiency and mixing effect between the sample and the diluent. After that, when adding the staining solution to the reaction cell 101, the diluent can also be synchronously added to improve the mixing efficiency and mixing effect among the staining solution, the sample and the diluent, ultimately improving the mixing degree of the sample solution to improve the accuracy of subsequent sample detection based on the sample solution.

[0067] Optionally, controlling the first aspiration and ejection component 108 to eject the reaction reagent into the above-mentioned reaction cell 101 and controlling the sampling needle 1041 to inject the sample into the reaction cell 101 includes:

[0068] Controlling the first aspiration and ejection component 108 to eject a third preset amount of the reaction reagent into the above-mentioned reaction cell 101 and controlling the sampling needle 1041 to inject the sample into the reaction cell 101.

[0069] Controlling the sampling needle 1041 to inject the staining solution into the reaction cell 101 to obtain the sample solution includes:

[0070] Controlling the sampling needle 1041 to inject the staining solution into the reaction cell 101 and controlling the sampling needle 1041 to mix the liquid in the reaction cell 101 to obtain the sample solution.

[0071] Specifically, the third preset amount of the reaction reagent can be a diluent. First of all, it should be noted that for a certain amount of sample, when preparing its sample solution, there is a corresponding total limit on the amount of diluent to be added. If only a part of the total amount of diluent is synchronously added to the reaction cell 101 when adding the sample to the reaction cell 101, it is easy to cause insufficient mixing of the sample solution due to insufficient amount of diluent, and then it is easy to lead to a decrease in the accuracy of subsequent sample detection.

[0072] Based on the above method, when adding the sample to the reaction cell 101, all the diluent that needs to be added can be synchronously added to the reaction cell 101 for thorough mixing. Subsequently, when adding the staining solution to the mixture of the sample and the diluent, the sampling needle 1041 can be controlled to further mix the liquid in the reaction cell 101, improving the mixing degree between the staining solution and other substances, and then improving the accuracy of subsequent sample detection based on the sample solution.

[0073] Furthermore, controlling the sampling needle 1041 to mix the liquid in the reaction cell 101 includes:

[0074] Controlling the needle rod of the sampling needle 1041 to stir in the liquid in the reaction cell 101, and / or controlling the sampling needle 1041 to perform multiple aspiration and ejection operations in the liquid in the reaction cell 101.

[0075] Specifically, the mixture in the reaction cell 101 can be further stirred evenly by controlling the needle rod of the sampling needle 1041 to stir in the liquid in the reaction cell 101, or the mixture in the reaction cell 101 can be further stirred evenly by controlling the sampling needle 1041 to perform repeated cyclic operations of inhaling and ejecting the liquid in the reaction cell 101. The mixture in the reaction cell 101 can also be further stirred evenly by other methods.

[0076] Based on the above method, the mixing degree of each substance in the sample solution can be improved, and then the accuracy of subsequent sample detection based on the sample solution can be improved.

[0077] In one embodiment, controlling the cleaning of the sampling needle 1041 includes:

[0078] Controlling the sampling needle 1041 to move to the dye solution assembly 102, and controlling the cleaning of the sampling needle 1041 during the movement.

[0079] Specifically, during the process that the sampling needle 1041 adds the sample to the reaction cell 101 and leaves the reaction cell 101 to prepare to go to the dye solution assembly 102 to collect the dye solution, the inner wall and the outer wall of the sampling needle 1041 can be cleaned, so as to improve the cleaning efficiency and the reliability of the sample detection device.

[0080] Optionally, controlling the sampling needle 1041 to move to the dye solution assembly 102, and controlling the cleaning of the sampling needle 1041 during the movement includes:

[0081] Controlling the sampling needle 1041 to move to the dye solution assembly 102, controlling the cleaning of the sampling needle 1041 during the movement, and completing the cleaning of the sampling needle before the sampling needle 1041 reaches above the dye solution assembly 102.

[0082] Specifically, during the process that the sampling needle 1041 adds the sample to the reaction cell 101 and leaves the reaction cell 101 to prepare to go to the dye solution assembly 102 to collect the dye solution, the inner wall and the outer wall of the sampling needle 1041 can be cleaned, so that the sampling needle 1041 is cleaned before reaching the dye solution assembly 102, reducing the possibility that the sample remaining on the sampling needle 1041 contaminates the dye solution stored in the dye solution assembly 102, and improving the reliability of the sample detection device.

[0083] In one embodiment, as Figure 1 shown, the sample detection device further includes a cleaning solution assembly 109, a waste liquid assembly 110, a first switching valve 111, and a cleaning swab 112.

[0084] The cleaning solution assembly 109 is used to store the cleaning solution.

[0085] The waste liquid assembly 110 is used to store the waste liquid.

[0086] The cleaning swab 112 has a first accommodating cavity. The cleaning swab 112 is sleeved on the outer wall of the sampling needle 1041, so that at least part of the outer wall of the sampling needle 1041 is located in the first accommodating cavity. One end of the first opening of the cleaning swab 112 is connected to one end of the first switching valve 111, the other end of the first switching valve 111 is connected to the cleaning solution assembly 109, and the second opening of the cleaning swab 112 is connected to the waste liquid assembly 110.

[0087] Controlling the cleaning of the sampling needle 1041 includes:

[0088] Control the first switching valve 111 to open, and control a relative movement along the outer wall of the sampling needle 1041 to be generated between the cleaning swab 112 and the sampling needle 1041.

[0089] Specifically, the cleaning liquid can specifically be a diluent, or can also be other types of cleaning liquids, which is not limited herein.

[0090] When the first switching valve 111 is opened, due to the power provided by the cleaning liquid assembly 109 itself, the cleaning liquid can flow from the cleaning liquid assembly 109, pass through the first switching valve 111, enter the first accommodation cavity of the cleaning swab 112 through the first opening of the cleaning swab 112, and after flushing the outer wall of the sampling needle 1041, leave the first accommodation cavity of the cleaning swab 112 through the second opening of the cleaning swab 112 and flow into the waste liquid assembly 110.

[0091] In the above process, a liquid flow formed by the cleaning liquid for flushing the outer wall of the sampling needle 1041 can be formed in the first accommodation cavity, and then control the cleaning swab 112 to move back and forth on the outer wall along the axis of the sampling needle 1041, and the comprehensive flushing of the outer wall of the sampling needle 1041 can be realized based on this liquid flow, and the cleaning of the outer wall of the sampling needle 1041 can be completed.

[0092] Optionally, as Figure 1 shown, the sample detection device further includes a second switching valve 113, the sampling assembly 104 further includes a syringe 1042, the syringe 1042 has a second accommodation cavity, the first opening of the syringe 1042 is connected to the tail end of the sampling needle 1041, the second opening of the syringe 1042 is connected to one end of the second switching valve 113, and the other end of the second switching valve 113 is connected to the cleaning liquid assembly 109.

[0093] Controlling the cleaning of the sampling needle 1041 includes:

[0094] Control the cleaning swab 112 to move so that the needle opening of the sampling needle 1041 is located in the first accommodation cavity, and control the second switching valve 113 to open.

[0095] Specifically, when the second switching valve 113 is opened, due to the power provided by the cleaning liquid assembly 109 itself, the cleaning liquid can flow from the cleaning liquid assembly 109, enter the second accommodation cavity of the syringe 1042 through the second opening of the syringe 1042, then pass through the tail end and the needle head of the sampling needle 1041, flow into the first accommodation cavity, and then flow into the waste liquid assembly 110 from the second opening of the cleaning swab 112.

[0096] In the above process, the cleaning liquid can flush the second accommodation cavity and the inner wall of the sampling needle 1041, and complete the cleaning of the second accommodation cavity and the inner wall of the sampling needle 1041.

[0097] In one embodiment, asFigure 1 As shown, the sample detection device further includes a third switching valve 114.

[0098] The reaction tank 101 can be connected to one end of the third switching valve 114, and the other end of the third switching valve 114 can be connected to the waste liquid assembly 110. When the third switching valve 114 is opened, the residual liquid in the reaction tank 101 can be discharged into the waste liquid assembly 110 through the third switching valve 114.

[0099] In one embodiment, as Figure 1 As shown, the sample detection device further includes a fourth switching valve 115. The first opening of the syringe 1042 is connected to one end of the fourth switching valve 115, and the other end of the fourth switching valve 115 is connected to the tail of the sampling needle 1041. The fourth switching valve 115 can be opened when liquid needs to flow between the first opening of the syringe 1042 and the tail of the sampling needle 1041, and vice versa.

[0100] In one embodiment, as Figure 1 As shown, the sample detection device further includes a fifth switching valve 116. The detection component 105 is connected to one end of the fifth switching valve 116, and the other end of the fifth switching valve 116 is connected to the reaction tank 101. The fifth switching valve 116 can be opened after the sample liquid in the reaction tank 101 is prepared, to control the detection component 105 to perform sample detection on the sample liquid received from the reaction tank 101 and obtain a detection result.

[0101] This application also proposes a sample detection method, which is applied to the sample detection device. The method is used for:

[0102] Controlling the sampling needle to collect a sample from the sample assembly;

[0103] Controlling the sampling needle to inject the sample into the reaction tank;

[0104] Controlling the sampling needle to be cleaned;

[0105] Controlling the sampling needle to collect a dye solution from the dye solution assembly;

[0106] Controlling the sampling needle to inject the dye solution into the reaction tank to obtain a sample liquid;

[0107] Controlling the detection component to perform sample detection on the sample liquid to obtain a detection result. In this application, the sample detection device 21 can specifically be the sample detection device described in any of the previous embodiments, which will not be elaborated here.

[0108] Different from the prior art, in the technical solution of the present application, the sample detection device includes a reaction cell, a dye solution assembly, a sample assembly, a sampling assembly, a detection assembly, and a control assembly. The control assembly controls the sampling needle to collect a sample from the sample assembly, controls the sampling needle to inject the sample into the reaction cell, controls the sampling needle to be cleaned, controls the sampling needle to collect a dye solution from the dye solution assembly, controls the sampling needle to inject the dye solution into the reaction cell to obtain a sample solution, and controls the detection assembly to perform sample detection on the sample solution to obtain a detection result. Based on the above method, the dye solution assembly and the reaction cell can be separately arranged independently of each other. Since there is no fixed connecting pipeline between the dye solution assembly and the reaction cell, and the dye solution is added to the reaction cell by extracting it from the dye solution assembly with a sampling needle and injecting it into the reaction cell, the situation of dye solution diffusion caused by long-term static placement between the dye solution assembly and the reaction cell can be avoided. Furthermore, the need to discard the dye solution contaminated by dye solution diffusion can be avoided, reducing the additional consumption of the dye solution and improving the utilization rate of the dye solution.

[0109] In the description of the present application, the description with reference to terms such as "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0110] In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present application, the meaning of "a plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0111] Any process or method description shown in a flowchart or described in other ways herein can be understood as representing a module, segment, or part of code including one or more executable instructions for implementing a specific logical function or process. The scope of the preferred embodiments of the present application includes additional implementations, where the functions can be executed in a manner that is not shown or discussed in the order, including in a substantially simultaneous manner according to the involved functions or in a reverse order, which should be understood by those skilled in the art of the embodiments of the present application.

[0112] The logic and / or steps represented in the flowchart or otherwise described herein can, for example, be considered a sequenced list of executable instructions for implementing logical functions, which can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device (which can be a personal computer, server, network device, or other system that can fetch and execute instructions from the instruction execution system, apparatus, or device). For the purposes of this specification, a "computer-readable medium" can be any device that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of the computer-readable medium include the following: an electrical connection portion having one or more wirings (electronic device), a portable computer diskette (magnetic device), a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium can even be paper or other suitable medium on which the program can be printed, as the program can be obtained electronically, for example, by optically scanning the paper or other medium, followed by editing, interpretation, or otherwise processing as appropriate, and then storing it in a computer memory.

[0113] The above are only the embodiments of the present application, and do not limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of the present application, or directly or indirectly applied in other related technical fields, shall be equally included in the patent protection scope of the present application.

Claims

1. A sample detection device, characterized in that, it includes: a reaction pool; a dye solution component for storing a dye solution, and the dye solution component is arranged adjacent to the reaction pool; a sample component for storing a sample; a sampling component including a sampling needle; a detection component; a control component, and the control component is used for: controlling the sampling needle to collect a sample from the sample component; controlling the sampling needle to inject the sample into the reaction pool; controlling the sampling needle to be cleaned; controlling the sampling needle to collect a dye solution from the dye solution component; controlling the sampling needle to inject the dye solution into the reaction pool to obtain a sample solution; controlling the detection component to perform sample detection on the sample solution to obtain a detection result.

2. The sample detection device according to claim 1, characterized in that, the sample detection device further includes: a first three-way valve, and a first branch port of the first three-way valve is connected to the reaction pool; a reaction reagent component, and the reaction reagent component is connected to a second branch port of the first three-way valve; a first suction and discharge component, and the first suction and discharge component is connected to a common port of the first three-way valve; the control component is further used for: controlling the first three-way valve to conduct its second branch port and its common port; controlling the first suction and discharge component to suck a reaction reagent from the reaction reagent component; controlling the first three-way valve to conduct its first branch port and its common port; controlling the first suction and discharge component to spit the reaction reagent into the reaction pool and controlling the sampling needle to inject the sample into the reaction pool.

3. The sample detection device according to claim 2, characterized in that, the control component is further used for: controlling the first suction and discharge component to spit a first preset amount of the reaction reagent into the reaction pool and controlling the sampling needle to inject the sample into the reaction pool; controlling the first suction and discharge component to spit a second preset amount of the reaction reagent into the reaction pool and controlling the sampling needle to inject the dye solution into the reaction pool to obtain the sample solution.

4. The sample detection device according to claim 2, characterized in that, the control component is further used for: controlling the first suction and discharge component to spit a third preset amount of the reaction reagent into the above reaction pool and controlling the sampling needle to inject the sample into the reaction pool; controlling the sampling needle to inject the dye solution into the reaction pool and controlling the sampling needle to mix the liquid in the reaction pool to obtain the sample solution.

5. The sample detection device according to claim 4, characterized in that, the control component is further used for: controlling the needle rod of the sampling needle to stir in the liquid in the reaction pool, and / or controlling the sampling needle to perform multiple suction and discharge operations on the liquid in the reaction pool.

6. The sample detection device according to any one of claims 1 to 5, characterized in that, the control component is further used for: controlling the sampling needle to move to the dye solution component and controlling the sampling needle to be cleaned during the movement.

7. The sample detection device according to claim 6, characterized in that, the control component is further used for: Control the sampling needle to move to the dye solution assembly, and control the cleaning of the sampling needle during the movement, and complete the cleaning of the sampling needle before the sampling needle reaches above the dye solution assembly.

8. The sample detection device according to any one of claims 1 to 5, characterized in that the sample detection device further includes: a cleaning solution assembly for storing a cleaning solution; a waste liquid assembly for storing waste liquid; a first switching valve; a cleaning swab having a first accommodation cavity, the cleaning swab is sleeved on the outer wall of the sampling needle so that at least a part of the outer wall of the sampling needle is located in the first accommodation cavity, a first opening of the cleaning swab is connected to one end of the first switching valve, the other end of the first switching valve is connected to the cleaning solution assembly, and a second opening of the cleaning swab is connected to the waste liquid assembly; The control component is further configured to: control the first switching valve to open, and control a relative movement along the outer wall of the sampling needle between the cleaning swab and the sampling needle.

9. The sample detection device according to claim 8, characterized in that the sample detection device further includes: a second switching valve; the sampling assembly further includes a syringe having a second accommodation cavity, a first opening of the syringe is connected to the tail of the sampling needle, a second opening of the syringe is connected to one end of the second switching valve, and the other end of the second switching valve is connected to the cleaning solution assembly; The control component is further configured to: control the cleaning swab to move so that the needle opening of the sampling needle is located in the first accommodation cavity, and control the second switching valve to open.

10. A sample detection method, characterized in that applied to the sample detection device according to any one of claims 1 to 9, the method is used for: controlling the sampling needle to collect a sample from the sample assembly; controlling the sampling needle to inject the sample into the reaction pool; controlling the sampling needle to be cleaned; controlling the sampling needle to collect a dye solution from the dye solution assembly; controlling the sampling needle to inject the dye solution into the reaction pool to obtain a sample solution; controlling the detection component to perform sample detection on the sample solution to obtain a detection result.

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