Detection method and system for measuring radioactive impurities in sodium pertechnetate injection

Abstract

The invention relates to the technical field of sodium pertechnetate injection detection, in particular to a detection method and system for measuring radioactive impurities in a sodium pertechnetate injection.The system comprises a frame body, a box body, a box cover and a mixing mechanism; the box body is arranged on the frame body, the box cover is arranged on the box body, the mixing mechanism comprises a power assembly, a displacement frame, a rotating shaft, a swing frame, a plurality of placing pieces, a gear, a rack and a pressing assembly, the box body is provided with a sliding groove, the displacement frame is slidably connected with the sliding groove, the rack is arranged in the box body, and the rotating shaft is rotatably connected with the displacement frame; the two ends of the rotating shaft are fixedly connected with the gear and the swing frame respectively, the gear is meshed with the rack, the multiple placement pieces are all arranged on the swing frame, and the power assembly is used for driving the displacement frame to move, so that the technical problem that in the prior art, the shaking-up effect on substances in the low-potassium scintillation bottle is poor, and then the detection effect on radioactive impurities is affected is solved.

Description

Technical Field

[0001] The present invention relates to the technical field of detection of sodium pertechnetate injection, and particularly to a detection method and system for measuring radioactive impurities in sodium pertechnetate injection. Background Art

[0002] Sodium pertechnetate injection, namely sodium pertechnetate [99mTc] injection, is a radioactive diagnostic drug mainly composed of sodium pertechnetate [99mTc]. Its chemical formula is Na[TcO4], in which technetium-99m (99mTc) is an isotope with specific radioactive characteristics. This injection is usually colorless and clear, and is mainly used in the medical field for various examination items such as thyroid imaging, brain imaging, salivary gland imaging, and ectopic gastric mucosa imaging. Radioactive impurities may be introduced during the production process of sodium pertechnetate injection, and the presence of these impurities may affect the quality and safety of the injection. Therefore, it is crucial to accurately detect the radioactive impurities in sodium pertechnetate injection.

[0003] In a detection method for measuring radioactive impurities in sodium pertechnetate injection disclosed in the existing patent publication number CN113970564A, one step is to take the eluate and add it to a low-potassium scintillation vial, and then add a scintillation solution and shake well. However, in this method, the shaking effect of the substances in the low-potassium scintillation vial is not good, which in turn affects the detection effect of radioactive impurities. Summary of the Invention

[0004] The purpose of the present invention is to provide a detection method and system for measuring radioactive impurities in sodium pertechnetate injection, aiming to solve the technical problem that the shaking effect of the substances in the low-potassium scintillation vial in the prior art is not good, which in turn affects the detection effect of radioactive impurities.

[0005] To achieve the above purpose, a detection system for measuring radioactive impurities in sodium pertechnetate injection adopted by the present invention includes a frame body, a box body, a box cover, and a mixing mechanism; the box body is arranged on the frame body, the box cover is arranged on the box body, the mixing mechanism includes a power component, a displacement frame, a rotating shaft, a swinging frame, a plurality of placing components, a gear, a rack, and a pressing component, the box body has a sliding groove, the displacement frame is slidably connected to the sliding groove, the rack is arranged in the box body, the rotating shaft is rotatably connected to the displacement frame, and both ends of the rotating shaft are respectively fixedly connected to the gear and the swinging frame, the gear is engaged with the rack, and a plurality of the placing components are all arranged on the swinging frame, and the power component is used to drive the displacement frame to move.

[0006] Among them, the power assembly includes a driving unit, a T-shaped member, a resisting rod, and a stress rod. The stress rod is slidably connected to the displacement frame. The stress rod has a stress groove, and the resisting rod is placed in the stress groove. The T-shaped member is fixedly connected to the resisting rod, and the driving unit is used to drive the T-shaped member to move.

[0007] Among them, the driving unit includes a biaxial motor, a disc, and a support rod. The T-shaped member has a through hole. The biaxial motor is installed in the box body. One output end of the biaxial motor is fixedly connected to the disc, one end of the support rod is fixedly connected to the disc, and the other end of the support rod is placed in the through hole.

[0008] Among them, the T-shaped member includes a block body and a connecting block. One end of the connecting block is fixedly connected to the resisting rod, and the other end of the connecting block is fixedly connected to the block body.

[0009] Among them, the displacement frame includes a sliding plate and a support plate. The sliding plate is slidably connected to the sliding groove, and the support plate is fixedly connected to the sliding plate.

[0010] Among them, the swing frame includes a connecting rod and a mounting plate. The connecting rod is fixedly connected to the end of the rotating shaft away from the gear, and the mounting plate is fixedly connected to the rotating shaft.

[0011] Among them, the pressing assembly includes a screw rod, a force-applying block, and a pressing plate. The connecting rod has a groove. The pressing plate is slidably connected to the groove. The screw rod is rotatably connected to the connecting rod. The screw rod is also in threaded cooperation with the pressing plate. The force-applying block is fixedly connected to the screw rod.

[0012] The present invention also provides a detection method for measuring radioactive impurities in sodium pertechnetate injection, which is applied to the detection system for measuring radioactive impurities in sodium pertechnetate injection as described above.

[0013] It includes the following steps:

[0014] First, place the sodium pertechnetate injection sample in a constant temperature environment and let it stand still.

[0015] Elute the standing sample through an anion exchange resin column and collect the eluate.

[0016] Divide the eluate into low-potassium scintillation vials, add an appropriate amount of scintillation solution, and then place the low-potassium scintillation vials in the corresponding placement members.

[0017] Start the power assembly. The power assembly drives the displacement frame to move horizontally, and the displacement frame drives the swing frame, that is, the low-potassium scintillation vials in the placement members, to move horizontally back and forth.

[0018] Meanwhile, when the swing frame moves horizontally, it drives the gear to move horizontally. Since the gear meshes with the rack, the gear rotates and then drives the rotating shaft and the swing frame to swing reciprocally.

[0019] Place the shaken low-potassium scintillation vial in a liquid scintillation counter, and use the α / β analysis method to finely detect the radioactive impurities in the eluate.

[0020] In the specific use of a detection method and system for measuring radioactive impurities in sodium pertechnetate injection according to the present invention, first, place the sodium pertechnetate injection sample in a constant temperature environment and let it stand and stabilize for a period of time. Then, elute the stabilized sample through an anion exchange resin column, collect the eluate, divide the eluate into low-potassium scintillation vials, and add an appropriate amount of scintillation fluid. Subsequently, place the low-potassium scintillation vial in the corresponding placement member; start the power assembly, the power assembly drives the displacement frame to move horizontally, the displacement frame drives the swing frame, that is, the low-potassium scintillation vial in the placement member, to move horizontally and reciprocally; meanwhile, when the swing frame moves horizontally, it drives the gear to move horizontally. Since the gear meshes with the rack, the gear rotates and then drives the rotating shaft and the swing frame to swing reciprocally; place the shaken low-potassium scintillation vial in a liquid scintillation counter, and use the α / β analysis method to finely detect the radioactive impurities in the eluate, thereby solving the technical problem in the prior art that the shaking effect of the substances in the low-potassium scintillation vial is not good, which in turn affects the detection effect of radioactive impurities. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0022] Figure 1 is a schematic structural diagram of the first embodiment of the present invention.

[0023] Figure 2 is a partial structural schematic diagram of the first embodiment of the present invention.

[0024] Figure 3 is a partial structural schematic diagram of the first embodiment of the present invention.

[0025] Figure 4 is of the present invention Figure 2 is an enlarged partial structural view of part A.

[0026] Figure 5 is of the present invention Figure 2Partial enlarged view of the structure at position B.

[0027] Figure 6 is of the present invention Figure 3 Cross-sectional view of the structure along the C-C line.

[0028] Figure 7 is a schematic structural view of the second embodiment of the present invention.

[0029] 101 - Frame body, 102 - Box body, 103 - Box cover, 104 - Rotating shaft, 105 - Placing member, 106 - Gear, 107 - Rack, 108 - Supporting rod, 109 - Force-bearing rod, 110 - Biaxial motor, 111 - Disc, 112 - Support rod, 113 - Block, 114 - Connecting block, 115 - Slide plate, 116 - Support plate, 117 - Connecting rod, 118 - Mounting plate, 119 - Screw, 120 - Force-applying block, 121 - Pressing plate, 122 - Chute, 123 - Force-bearing groove, 124 - Through hole, 125 - Groove, 201 - Guide rod, 202 - Frame, 203 - Spring, 204 - Round shaft, 205 - Cam. Detailed implementation manners

[0030] The embodiments of the present invention will be described in detail below. The examples of the embodiments are shown in the drawings. The embodiments described below with reference to the drawings are exemplary and are intended to explain the present invention, and should not be construed as a limitation to the present invention.

[0031] The first embodiment of the present application is as follows:

[0032] Please refer to Figures 1 to 6 where Figure 1 is a schematic structural view of the first embodiment of the present invention. Figure 2 is a partial structural view of the first embodiment of the present invention. Figure 3 is a partial structural view of the first embodiment of the present invention. Figure 4 is of the present invention Figure 2 Partial enlarged view of the structure at position A. Figure 5 is of the present invention Figure 2 Partial enlarged view of the structure at position B. Figure 6 is of the present invention Figure 3 Cross-sectional view of the structure along the C-C line.

[0033] The present invention provides a detection system for measuring radioactive impurities in sodium pertechnetate injection, including a frame body 101, a box body 102, a box cover 103 and a mixing mechanism; the mixing mechanism includes a power assembly, a displacement frame, a rotating shaft 104, a swinging frame, a plurality of placing members 105, a gear 106, a rack 107 and a pressing assembly, the power assembly includes a driving unit, a T-shaped member, a resisting rod 108 and a stress rod 109, the driving unit includes a double-shaft motor 110, a disc 111 and a support rod 112, the T-shaped member includes a block body 113 and a connecting block 114, the displacement frame includes a sliding plate 115 and a support plate 116, the swinging frame includes a connecting rod 117 and a mounting plate 118, the pressing assembly includes a screw rod 119, a force-applying block 120 and a pressing plate 121. The foregoing solution solves the technical problem in the prior art that the shaking effect of the substances in the low-potassium scintillation vial is not good, thereby affecting the detection effect of radioactive impurities.

[0034] For this specific embodiment, the box body 102 is arranged on the frame body 101, the box cover 103 is arranged on the box body 102, and the box cover 103 is used to seal the inside of the box body 102.

[0035] Among them, the box body 102 has a sliding groove 122, the displacement frame is slidably connected to the sliding groove 122, the rack 107 is arranged inside the box body 102, the rotating shaft 104 is rotatably connected to the displacement frame, and both ends of the rotating shaft 104 are fixedly connected to the gear 106 and the swinging frame respectively, the gear 106 meshes with the rack 107, and a plurality of the placing members 105 are all arranged on the swinging frame. The power assembly is used to drive the displacement frame to move. During specific use, first, the sodium pertechnetate injection sample is placed in a constant temperature environment and left to stand and stabilize for a period of time. Then, the stabilized sample is eluted through an anion exchange resin column, the eluate is collected, the eluate is sub-packed into low-potassium scintillation vials, and an appropriate amount of scintillation liquid is added. Subsequently, the low-potassium scintillation vials are placed in the corresponding placing members 105; the power assembly is started, and the power assembly drives the displacement frame to move horizontally, and the displacement frame drives the swinging frame, that is, the low-potassium scintillation vials in the placing members 105 to move horizontally back and forth; at the same time, when the swinging frame moves horizontally, it drives the gear 106 to move horizontally. Because the gear 106 meshes with the rack 107, the gear 106 rotates, thereby driving the rotating shaft 104 and the swinging frame to swing back and forth; the shaken low-potassium scintillation vials are placed in a liquid scintillation counter, and the α / β analysis method is used to finely detect the radioactive impurities in the eluate. In this way, the technical problem in the prior art that the shaking effect of the substances in the low-potassium scintillation vial is not good, thereby affecting the detection effect of radioactive impurities is solved.

[0036] Secondly, the force-bearing rod 109 is slidably connected to the displacement frame. The force-bearing rod 109 has a force-bearing groove 123. The force-bearing rod 109 is placed in the force-bearing groove 123. The T-shaped member is fixedly connected to the abutting rod 108, and the driving unit is used to drive the T-shaped member to move;

[0037] During use, the driving unit drives the T-shaped member to move. The T-shaped member drives the abutting rod 108 to move vertically in the force-bearing groove 123, and then drives the force-bearing rod 109 to move horizontally. The force-bearing rod 109 can drive the displacement frame to move.

[0038] Meanwhile, the T-shaped member has a through hole 124. The double-shaft motor 110 is installed in the box body 102. One output end of the double-shaft motor 110 is fixedly connected to the disc 111. One end of the support rod 112 is fixedly connected to the disc 111, and the other end of the support rod 112 is placed in the through hole 124;

[0039] One end of the connecting block 114 is fixedly connected to the abutting rod 108, and the other end of the connecting block 114 is fixedly connected to the block 113. When the double-shaft motor 110 is started, the corresponding output end of the double-shaft motor 110 drives the disc 111 to rotate. The disc 111 drives the support rod 112 to slide in the through hole 124. While the support rod 112 slides in the through hole 124, it drives the block 113 to move. The block 113 then drives the abutting rod 108 to move through the connecting block 114.

[0040] In addition, the sliding plate 115 is slidably connected to the sliding groove 122. The support plate 116 is fixedly connected to the sliding plate 115. When the force-bearing rod 109 moves, it drives the sliding plate 115 to slide in the sliding groove 122, and the sliding plate 115 drives the support plate 116 to move.

[0041] Again, the connecting rod 117 is fixedly connected to the end of the rotating shaft 104 away from the gear 106. The mounting plate 118 is fixedly connected to the rotating shaft 104. When the support plate 116 moves, it drives the rotating shaft 104 to move. The rotating shaft 104 drives the connecting rod 117 to move and then drives the mounting plate 118 to move. The mounting plate 118 is used to mount the placing member 105.

[0042] Finally, the connecting rod 117 has a groove 125, the pressing plate 121 is slidably connected to the groove 125, the screw 119 is rotatably connected to the connecting rod 117, the screw 119 is also in threaded cooperation with the pressing plate 121, and the force - applying block 120 is fixedly connected to the screw 119. After placing the low - potassium scintillation vial in the corresponding placement member 105, turn the force - applying block 120. The force - applying block 120 drives the screw 119 to rotate, and the screw 119 drives the pressing plate 121 to press on the low - potassium scintillation vial in the placement member 105, preventing it from slipping during swinging.

[0043] When using the detection system for measuring radioactive impurities in sodium pertechnetate injection of this embodiment, in specific use, first place the sodium pertechnetate injection sample in a constant - temperature environment and let it stand and stabilize for a period of time. Then elute the stabilized sample through an anion - exchange resin column, collect the eluate, divide the eluate into low - potassium scintillation vials, and add an appropriate amount of scintillation fluid. Subsequently, place the low - potassium scintillation vials in the corresponding placement members 105; start the power assembly, the power assembly drives the displacement frame to move horizontally, and the displacement frame drives the swing frame, that is, the low - potassium scintillation vials in the placement members 105, to move horizontally back and forth; at the same time, when the swing frame moves horizontally, it drives the gear 106 to move horizontally. Because the gear 106 meshes with the rack 107, the gear 106 rotates and then drives the rotating shaft 104 and the swing frame to swing reciprocally; place the shaken low - potassium scintillation vial in a liquid scintillation counter, and use the α / β analysis method to finely detect the radioactive impurities in the eluate. In this way, the technical problem in the prior art that the shaking effect of the substances in the low - potassium scintillation vial is not good, thus affecting the detection effect of radioactive impurities, is solved.

[0044] The second embodiment of the present application is as follows:

[0045] On the basis of the first embodiment, please refer to Figure 7 , Figure 7 which is the structural schematic diagram of the second embodiment of the present invention.

[0046] The present invention provides a detection system for measuring radioactive impurities in sodium pertechnetate injection, further including a plurality of guide rods 201, a frame 202, a plurality of springs 203, a round shaft 204, and a cam 205.

[0047] For this specific embodiment, the frame 202 is fixedly connected to the box body 102. One end of each of the plurality of guide rods 201 is fixedly connected to the base, and the other end of each of the plurality of guide rods 201 penetrates through the frame 202. Both ends of the spring 203 are fixedly connected to the frame 202 and the base respectively. The cam 205 is fixedly connected to the output end of the dual-axis motor 110 away from the disc 111 through the round shaft 204. During specific use, the corresponding output end of the dual-axis motor 110 drives the cam 205 to rotate through the round shaft 204, and the cam 205 abuts against the base, so that the round shaft 204 can drive the box body 102 to move upward. After the cam 205 rotates to a specified position, the box body 102 will reset downward, and in this way, the up-and-down reciprocating movement of the box body 102 is realized repeatedly, further improving the mixing effect.

[0048] When using a detection system for measuring radioactive impurities in sodium pertechnetate injection according to this embodiment, during specific use, the corresponding output end of the dual-axis motor 110 drives the cam 205 to rotate through the round shaft 204, and the cam 205 abuts against the base, so that the round shaft 204 can drive the box body 102 to move upward. After the cam 205 rotates to a specified position, the box body 102 will reset downward, and in this way, the up-and-down reciprocating movement of the box body 102 is realized repeatedly, further improving the mixing effect.

[0049] The present invention also provides a detection method for measuring radioactive impurities in sodium pertechnetate injection, which is applied to the detection system for measuring radioactive impurities in sodium pertechnetate injection as described above.

[0050] It includes the following steps:

[0051] First, place the sodium pertechnetate injection sample in a constant temperature environment and let it stand still.

[0052] Elute the standing sample through an anion exchange resin column and collect the eluate.

[0053] Divide the eluate into low-potassium scintillation vials, add an appropriate amount of scintillation solution, and then place the low-potassium scintillation vials in the corresponding placement members 105.

[0054] Start the power assembly, the power assembly drives the displacement frame to move horizontally, and the displacement frame drives the swing frame, that is, the low-potassium scintillation vials in the placement member 105, to move horizontally back and forth.

[0055] At the same time, when the swing frame moves horizontally, it drives the gear 106 to move horizontally. Since the gear 106 meshes with the rack 107, the gear 106 rotates and then drives the rotating shaft 104 and the swing frame to swing back and forth.

[0056] Place the shaken low-potassium scintillation vial in a liquid scintillation counter and use the α / β analysis method to finely detect the radioactive impurities in the eluate.

[0057] The above-disclosed is only a preferred embodiment of the present invention. Of course, it cannot be used to limit the scope of the rights of the present invention. Those of ordinary skill in the art can understand all or part of the processes of implementing the above embodiments, and the equivalent changes made according to the claims of the present invention still fall within the scope covered by the invention.

Claims

1. A detection system for measuring radioactive impurities in sodium pertechnetate injection, comprising a frame, a box and a box cover, wherein the box is arranged on the frame, and the box cover is arranged on the box, characterized in that: It also includes hybrid institutions; The mixing mechanism includes a power assembly, a displacement frame, a rotating shaft, a swing frame, multiple placement members, a gear, a rack and a clamping assembly. The box body has a slide groove, the displacement frame is slidably connected to the slide groove, the rack is arranged in the box body, the rotating shaft is rotatably connected to the displacement frame, and the two ends of the rotating shaft are respectively fixedly connected to the gear and the swing frame, the gear is meshed with the rack, and the multiple placement members are all arranged on the swing frame. The power assembly is used to drive the displacement frame to move.

2. The detection system for measuring radioactive impurities in sodium pertechnetate injection according to claim 1, characterized in that: The power assembly includes a driving unit, a T-shaped piece, a supporting rod and a force-bearing rod. The force-bearing rod is slidably connected to the displacement frame, the force-bearing rod has a force-bearing groove, the force-bearing rod is placed in the force-bearing groove, the T-shaped piece is fixedly connected to the supporting rod, and the driving unit is used to drive the T-shaped piece to move.

3. The detection system for measuring radioactive impurities in sodium pertechnetate injection according to claim 2, characterized in that: The driving unit includes a dual-axis motor, a disc and a support rod. The T-shaped piece has a through hole. The dual-axis motor is installed in the box. One of the output ends of the dual-axis motor is fixedly connected to the disc. One end of the support rod is fixedly connected to the disc, and the other end of the support rod is placed in the through hole.

4. The detection system for measuring radioactive impurities in sodium pertechnetate injection according to claim 3, characterized in that: The T-shaped piece comprises a block body and a connecting block, one end of the connecting block is fixedly connected to the supporting rod, and the other end of the connecting block is fixedly connected to the block body.

5. The detection system for measuring radioactive impurities in sodium pertechnetate injection according to claim 4, characterized in that: The displacement frame comprises a slide plate and a support plate, the slide plate is slidably connected to the slide groove, and the support plate is fixedly connected to the slide plate.

6. The detection system for measuring radioactive impurities in sodium pertechnetate injection according to claim 5, characterized in that: The swing frame includes a connecting rod and a mounting plate. The connecting rod is fixedly connected to an end of the rotating shaft away from the gear, and the mounting plate is fixedly connected to the rotating shaft.

7. The detection system for measuring radioactive impurities in sodium pertechnetate injection according to claim 6, characterized in that: The clamping assembly includes a screw rod, a force block and a clamping plate. The connecting rod has a groove. The clamping plate is slidably connected to the groove. The screw rod is rotationally connected to the connecting rod. The screw rod is also threadably matched with the clamping plate. The force block is fixedly connected to the screw rod.

8. A method for measuring radioactive impurities in sodium pertechnetate injection, applied to the detection system for measuring radioactive impurities in sodium pertechnetate injection as claimed in claim 7, characterized in that: The steps include: Firstly, the sodium pertechnetate injection sample is placed in a constant temperature environment and allowed to stand; The sample after standing is eluted through an anion exchange resin column, and the eluate is collected; The eluate is divided into low potassium scintillation vials, and an appropriate amount of scintillation fluid is added, and then the low potassium scintillation vials are placed in the corresponding placement pieces; The power assembly is started, the power assembly drives the displacement rack to move horizontally, and the displacement rack drives the swing rack, i.e., the low potassium scintillation vial in the placement member, to move horizontally back and forth; At the same time, when the swing frame moves horizontally, it drives the gear to move horizontally. Since the gear is meshed with the rack, the gear rotates and drives the rotating shaft and the swing frame to swing back and forth. Place the shaken low potassium scintillation vial in a liquid scintillation counter and use the α / β analysis method to perform a detailed test on the radioactive impurities in the eluate.

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