Chlorine-containing disinfectant and preparation method thereof

Abstract

The invention provides a chlorine-containing disinfectant and a preparation method thereof, and belongs to the technical field of disinfectants. The disinfectant is prepared from bromochlorohydantoin, sodium dichloroisocyanurate, rosmarinic acid, octenidine, sodium hexametaphosphate, polyhexamethylene biguanidine hydrochloride, potassium monopersulfate, potassium chloride, dialkyl dimethyl ammonium chloride, laurocapram, squalane, carvacrol and benzalkonium chloride. The composition formula is constructed by taking bromochlorohydantoin and sodium dichloroisocyanurate as core components, the potassium monopersulfate has an efficient and broad-spectrum microbial inactivation effect, the squalane is originally used for moistening, moisturizing, resisting oxidation, regulating grease secretion and the like, and the potassium chloride has a broad-spectrum bactericidal effect, and is non-toxic and residue-free; after the components are compounded, a more prominent killing effect is shown. The disinfectant has a good surface sterilization effect, the killing rate reaches 99.999%, and the killing rate on spores and amoeba cysts also reaches 98% or above.

Description

Technical Field

[0001] The present invention relates to the technical field of disinfectants, and specifically to a chlorine-containing disinfectant and a preparation method thereof. Background Art

[0002] Chlorine-containing disinfectants refer to disinfectants that can produce hypochlorous acid with microbicidal activity after being dissolved in water. Their microbicidal active ingredients are often expressed as available chlorine, including 84 disinfectant, bleaching powder / water, chlorine-containing disinfection powder or chlorine-containing effervescent tablets, etc. Hypochlorous acid has a small molecular weight, is easy to diffuse to the surface of bacteria and penetrate the cell membrane into the bacteria, causing the oxidation of the bacterial protein and leading to the death of bacteria. Therefore, chlorine-containing disinfectants can kill various microorganisms, including bacterial vegetative forms, viruses, fungi, Mycobacterium tuberculosis, and the most resistant bacterial spores, etc.

[0003] Such disinfectants include inorganic chlorine compounds (such as sodium hypochlorite, calcium hypochlorite, etc.) and organic chlorine compounds (such as sodium dichloroisocyanurate, trichloroisocyanuric acid, etc.). Inorganic chlorine is unstable in nature and is easily affected by light, heat, and moisture, resulting in the loss of active ingredients; organic chlorine is relatively stable, but it is also unstable after being dissolved in water. Chlorine-containing disinfectants belong to high-efficiency disinfectants, which have the characteristics of broad-spectrum, high-efficiency, and low toxicity, but they have a strong pungent smell, and moreover, their killing effects on spores and amoeba cysts are generally poor. Summary of the Invention

[0004] The present invention aims at the technical defects of the existing technology, and provides a chlorine-containing disinfectant and a preparation method thereof to solve the technical problem that the conventional chlorine-containing disinfectants have poor killing effects on spores and amoeba cysts.

[0005] To achieve the above technical objectives, the present invention adopts the following technical solutions: A chlorine-containing disinfectant, characterized by comprising the following components: bromochlorohydantoin, sodium dichloroisocyanurate, rosmarinic acid, octenidine, sodium hexametaphosphate, polyhexamethylene biguanide hydrochloride, potassium monopersulfate, potassium chloride, dialkyldimethylammonium chloride, laurocapram, squalane, carvacrol, benzalkonium chloride.

[0006] Preferably, the chlorine-containing disinfectant comprises the following components in parts by weight: 15-18 parts of bromochlorohydantoin, 7-9 parts of sodium dichloroisocyanurate, 2-4 parts of rosmarinic acid, 3-6 parts of octenidine, 1-2 parts of sodium hexametaphosphate, 1-3 parts of polyhexamethylene biguanide hydrochloride, 2-3 parts of potassium monopersulfate, 0.6-1.3 parts of potassium chloride, 0.8-1.5 parts of dialkyldimethylammonium chloride, 0.4-0.6 parts of laurocapram, 0.5-2 parts of squalane, 0.3-0.9 parts of carvacrol, 0.2-0.8 parts of benzalkonium chloride.

[0007] Preferably, the chlorine-containing disinfectant comprises the following components in parts by weight: 16-17 parts of bromochlorohydantoin, 7.5-8.5 parts of sodium dichloroisocyanurate, 2.2-3.5 parts of rosmarinic acid, 4.5-5 parts of octenidine, 1.2-1.8 parts of sodium hexametaphosphate, 2.3-2.7 parts of polyhexamethylene biguanide hydrochloride, 2.1-2.4 parts of potassium monopersulfate, 0.9-1.1 parts of potassium chloride, 1-1.2 parts of dialkyldimethylammonium chloride, 0.4-0.5 parts of laurocapram, 1.3-1.5 parts of squalane, 0.6-0.8 parts of carvacrol, 0.4-0.6 parts of benzalkonium chloride.

[0008] Preferably, the chlorine-containing disinfectant comprises the following components in parts by weight: 16.5 parts of bromochlorohydantoin, 8 parts of sodium dichloroisocyanurate, 2.8 parts of rosmarinic acid, 4.7 parts of octenidine, 1.6 parts of sodium hexametaphosphate, 2.4 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of potassium monopersulfate, 1 part of potassium chloride, 1.1 parts of dialkyldimethylammonium chloride, 0.45 parts of laurocapram, 1.4 parts of squalane, 0.7 parts of carvacrol, 0.5 parts of benzalkonium chloride.

[0009] Preferably, the chlorine-containing disinfectant further comprises 0.5-0.9 part by weight of nano-silica.

[0010] Preferably, the chlorine-containing disinfectant further comprises 1.2-2 parts by weight of menthol.

[0011] Preferably, the chlorine-containing disinfectant further comprises 2-3 parts by weight of sodium hypochlorite.

[0012] Preferably, the chlorine-containing disinfectant further comprises 0.4-0.8 part by weight of dibromocyanoacetamide.

[0013] Preferably, the chlorine-containing disinfectant is composed of the following components in parts by weight: 16.5 parts of bromochlorohydantoin, 8 parts of sodium dichloroisocyanurate, 2.8 parts of rosmarinic acid, 4.7 parts of octenidine, 1.6 parts of sodium hexametaphosphate, 2.4 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of potassium monopersulfate, 1 part of potassium chloride, 1.1 parts of dialkyldimethylammonium chloride, 0.45 parts of laurocapram, 1.4 parts of squalane, 0.7 parts of carvacrol, 0.5 parts of benzalkonium chloride, 0.8 part of nano-silica, 1.6 parts of menthol, 2.5 parts of sodium hypochlorite, 0.6 part of dibromocyanoacetamide.

[0014] On the basis of the above technical solutions, the present invention further provides a preparation method of the above chlorine-containing disinfectant, comprising the following steps: in a clean container, stir the formulated amounts of bromochlorohydantoin, sodium dichloroisocyanurate, rosmarinic acid, octenidine, sodium hexametaphosphate, and polyhexamethylene biguanide hydrochloride at room temperature for 30 - 35 min, then add 1.5 times the volume of deionized water, and then add the formulated amounts of potassium monopersulfate, potassium chloride, and dialkyldimethylammonium chloride. Adjust the temperature to 45 - 48 °C and continue stirring for 1 - 2 h. Then adjust the pH to 8.3 - 8.5, add 0.2 times the volume of glycerol, and then add the formulated amounts of laurocapram, squalane, carvacrol, and benzalkonium chloride, and stir for 1 - 1.5 h.

[0015] In the above technical solutions, although there are interactions and conversions among the aqueous solutions of bromochlorohydantoin, sodium dichloroisocyanurate, and potassium monopersulfate, they can coexist under certain conditions. When the solution is weakly acidic to neutral, the reaction rate is relatively slow, and all three can be observed to coexist within a short period. At this time, although a reaction occurs, the degree of reaction is relatively small, and it can be considered a coexistence state within a certain period. This is hereby explained.

[0016] In the above technical solutions, bromochlorohydantoin mainly exerts its disinfection and sterilization effects through its hydrolysis products hypobromous acid and hypochlorous acid. HBrO and HClO combine with the protoplasm in microorganisms in water, and then form stable nitrogen-halogen bonds with the nitrogen in proteins, interfering with the metabolic process and causing the death of microorganisms by poisoning. In addition, the Br generated during the sterilization process - can also be oxidized by active chlorine or hypochlorite to form hypobromite with higher bactericidal activity, which can strongly kill fungi, bacteria, and viruses. Sodium dichloroisocyanurate has strong oxidizing properties and has a strong germicidal effect on various pathogenic microorganisms such as viruses, bacterial spores, and fungi. It is a highly efficient bactericide with a wide range of applications. Rosmarinic acid is a natural antioxidant with broad-spectrum antibacterial activity and can inhibit the growth of a variety of bacteria and fungi. Octenidine is an antimicrobial agent due to its special effects on adhesion and the synthesis of chemical cell components and its high antibacterial activity against the whole cell. Sodium hexametaphosphate has excellent chelating ability and property stability and undergoes complexation reactions with metal ions by forming stable complexes.

[0017] Polyhexamethylene biguanide hydrochloride can effectively kill a variety of bacteria, including Gram-positive and Gram-negative bacteria, such as common pathogenic bacteria like Escherichia coli and Staphylococcus aureus. At the same time, it also has an inhibitory effect on fungi, can be used for the prevention and treatment of skin infections caused by fungi, and has an inhibitory effect on most viruses. As a disinfectant, polyhexamethylene biguanide hydrochloride can be used for disinfection and cleaning work in various occasions such as households, medical facilities, and industries. It can clean the surface of objects, remove dirt and grease, while maintaining the hygiene and safety of items.

[0018] Potassium monopersulfate can kill enteropathogenic bacteria, pyogenic cocci, pathogenic yeasts, etc. by destroying the cell membrane permeability, causing the outflow of cell contents, entering the bacteria, denaturing proteins, and interfering with the binding of DNA and RNA. In addition, it can effectively kill pathogenic microorganisms such as HIV, H5N1 avian influenza virus, foot-and-mouth disease virus, and coronavirus; squalane was originally mainly used for moisturizing, antioxidant, regulating oil secretion, etc.; potassium chloride has a broad-spectrum bactericidal effect, is non-toxic, residue-free, and environmentally friendly. After compounding by the present invention, each component shows a more prominent disinfection and sterilization effect. The present invention provides a chlorine-containing disinfectant and a preparation method thereof. This technical solution takes bromochlorohydantoin and sodium dichloroisocyanurate as the core components to construct a composition formula. This composition has a good surface sterilization effect, with a killing rate of 99.999%, and the killing rate of spores and amoeba cysts also reaches more than 98%. The present invention can be widely used in the field of medical and health, with prominent technical advantages. Detailed Embodiments

[0019] The following will describe the detailed embodiments of the present invention in detail. In order to avoid too many unnecessary details, the well-known structures or functions will not be described in detail in the following embodiments. The approximate language used in the following embodiments can be used for quantitative expressions, indicating that a certain change in quantity is allowed without changing the basic function. Unless otherwise defined, the technical and scientific terms used in the following embodiments have the same meaning as commonly understood by those skilled in the art to which the present invention belongs.

[0020] Example 1 A chlorine-containing disinfectant, which includes the following components in parts by weight: 15 parts of bromochlorohydantoin, 7 parts of sodium dichloroisocyanurate, 2 parts of rosmarinic acid, 3 parts of octenidine, 1 part of sodium hexametaphosphate, 1 part of polyhexamethylene biguanide hydrochloride, 2 parts of potassium monopersulfate, 0.6 part of potassium chloride, 0.8 part of dialkyldimethylammonium chloride, 0.4 part of laurocapram, 0.5 part of squalane, 0.3 part of carvacrol, and 0.2 part of benzalkonium chloride. Using this example to wipe the plastic surface and metal surface, and detecting the total microbial count, spore count, and amoeba cyst count before and after wiping, and calculating the killing rate. The results show that when this example is used for the plastic surface, the total microbial killing rate is 99.999%, the spore killing rate is 98.55%, and the amoeba cyst killing rate is 98.73%; when this example is used for the metal surface, the total microbial killing rate is 99.999%, the spore killing rate is 99.12%, and the amoeba cyst killing rate is 99.28%.

[0021] Example 2 A chlorine-containing disinfectant, which comprises the following components in parts by weight: 18 parts of bromochlorohydantoin, 9 parts of sodium dichloroisocyanurate, 4 parts of rosmarinic acid, 6 parts of octenidine, 2 parts of sodium hexametaphosphate, 3 parts of polyhexamethylene biguanide hydrochloride, 3 parts of potassium monopersulfate, 1.3 parts of potassium chloride, 1.5 parts of dialkyldimethylammonium chloride, 0.6 parts of laurocapram, 2 parts of squalane, 0.9 parts of carvacrol, and 0.8 parts of benzalkonium chloride. Using this example to wipe the plastic surface and metal surface, detecting the total microbial count, spore count and amoeba cyst count before and after wiping, and calculating the killing rate. The results show that when this example is used on the plastic surface, the total microbial killing rate is 99.999%, the spore killing rate is 98.86%, and the amoeba cyst killing rate is 98.52%; when this example is used on the metal surface, the total microbial killing rate is 99.999%, the spore killing rate is 99.07%, and the amoeba cyst killing rate is 99.44%.

[0022] Example 3 A chlorine-containing disinfectant, which comprises the following components in parts by weight: 16 parts of bromochlorohydantoin, 7.5 parts of sodium dichloroisocyanurate, 2.2 parts of rosmarinic acid, 4.5 parts of octenidine, 1.2 parts of sodium hexametaphosphate, 2.3 parts of polyhexamethylene biguanide hydrochloride, 2.1 parts of potassium monopersulfate, 0.9 parts of potassium chloride, 1 part of dialkyldimethylammonium chloride, 0.4 parts of laurocapram, 1.3 parts of squalane, 0.6 parts of carvacrol, and 0.4 parts of benzalkonium chloride. Using this example to wipe the plastic surface and metal surface, detecting the total microbial count, spore count and amoeba cyst count before and after wiping, and calculating the killing rate. The results show that when this example is used on the plastic surface, the total microbial killing rate is 99.999%, the spore killing rate is 98.79%, and the amoeba cyst killing rate is 98.24%; when this example is used on the metal surface, the total microbial killing rate is 99.999%, the spore killing rate is 99.30%, and the amoeba cyst killing rate is 99.43%.

[0023] Example 4 A chlorine-containing disinfectant, which comprises the following components in parts by weight: 17 parts of bromochlorohydantoin, 8.5 parts of sodium dichloroisocyanurate, 3.5 parts of rosmarinic acid, 5 parts of octenidine, 1.8 parts of sodium hexametaphosphate, 2.7 parts of polyhexamethylene biguanide hydrochloride, 2.4 parts of potassium monopersulfate, 1.1 parts of potassium chloride, 1.2 parts of dialkyldimethylammonium chloride, 0.5 part of laurocapram, 1.5 parts of squalane, 0.8 part of carvacrol, and 0.6 part of benzalkonium chloride. Using this example to wipe the plastic surface and the metal surface, the total microbial count, spore count, and amoeba cyst count before and after wiping were detected, and the killing rate was calculated. The results showed that when this example was used on the plastic surface, the total microbial killing rate was 99.999%, the spore killing rate was 98.14%, and the amoeba cyst killing rate was 98.37%; when this example was used on the metal surface, the total microbial killing rate was 99.999%, the spore killing rate was 99.19%, and the amoeba cyst killing rate was 99.34%.

[0024] Example 5 A chlorine-containing disinfectant, which comprises the following components in parts by weight: 16.5 parts of bromochlorohydantoin, 8 parts of sodium dichloroisocyanurate, 2.8 parts of rosmarinic acid, 4.7 parts of octenidine, 1.6 parts of sodium hexametaphosphate, 2.4 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of potassium monopersulfate, 1 part of potassium chloride, 1.1 parts of dialkyldimethylammonium chloride, 0.45 part of laurocapram, 1.4 parts of squalane, 0.7 part of carvacrol, and 0.5 part of benzalkonium chloride. Using this example to wipe the plastic surface and the metal surface, the total microbial count, spore count, and amoeba cyst count before and after wiping were detected, and the killing rate was calculated. The results showed that when this example was used on the plastic surface, the total microbial killing rate was 99.999%, the spore killing rate was 98.60%, and the amoeba cyst killing rate was 98.91%; when this example was used on the metal surface, the total microbial killing rate was 99.999%, the spore killing rate was 92.38%, and the amoeba cyst killing rate was 96.45%.

[0025] Example 6 A chlorine-containing disinfectant, the chlorine-containing disinfectant comprises the following components in parts by weight: 16.5 parts of bromochlorohydantoin, 8 parts of sodium dichloroisocyanurate, 2.8 parts of rosmarinic acid, 4.7 parts of octenidine, 1.6 parts of sodium hexametaphosphate, 2.4 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of potassium monopersulfate, 1 part of potassium chloride, 1.1 parts of dialkyldimethylammonium chloride, 0.45 parts of laurocapram, 1.4 parts of squalane, 0.7 parts of carvacrol, 0.5 parts of benzalkonium chloride, 0.7 parts of nano-silica, 1.6 parts of menthol, 2.5 parts of sodium hypochlorite, 0.6 parts of dibromocyanoacetamide. Using this example to wipe the plastic surface and metal surface, detecting the total microbial count, spore count and amoeba cyst count before and after wiping, and calculating the killing rate. The results show that when this example is used for the plastic surface, the total microbial killing rate is 99.999%, the spore killing rate is 99.32%, and the amoeba cyst killing rate is 99.78%; when this example is used for the metal surface, the total microbial killing rate is 99.999%, the spore killing rate is 99.93%, and the amoeba cyst killing rate is 99.95%.

[0026] Comparative Example 1 Commercially available 84 disinfectant, using this example to wipe the plastic surface and metal surface, detecting the total microbial count, spore count and amoeba cyst count before and after wiping, and calculating the killing rate. The results show that when this example is used for the plastic surface, the total microbial killing rate is 99.980%, the spore killing rate is 72.28%, and the amoeba cyst killing rate is 82.59%; when this example is used for the metal surface, the total microbial killing rate is 99.993%, the spore killing rate is 77.38%, and the amoeba cyst killing rate is 85.66%.

[0027] Comparative Example 2 Commercially available benzalkonium chloride disinfectant, using this example to wipe the plastic surface and metal surface, detecting the total microbial count, spore count and amoeba cyst count before and after wiping, and calculating the killing rate. The results show that when this example is used for the plastic surface, the total microbial killing rate is 99.276%, the spore killing rate is 65.92%, and the amoeba cyst killing rate is 68.25%; when this example is used for the metal surface, the total microbial killing rate is 99.321%, the spore killing rate is 73.10%, and the amoeba cyst killing rate is 75.74%.

[0028] The above has described the embodiments of the present invention in detail, but the content described is only the preferred embodiments of the present invention and is not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the scope of the application of the present invention shall be included within the protection scope of the present invention.

Claims

1. A chlorine-containing disinfectant, characterized in that Includes the following ingredients: bromochlorohydrin, sodium dichloroisocyanurate, rosmarinic acid, octenidine, sodium hexametaphosphate, polyhexamethylene biguanide hydrochloride, potassium monopersulfate, potassium chloride, dialkyldimethylammonium chloride, laurocaprol, squalane, carvacrol, benzalkonium chloride.

2. A chlorine-containing disinfectant according to claim 1, characterized in that: The chlorine-containing disinfectant comprises the following ingredients in parts by weight: 15-18 parts of bromochlorohydantoin, 7-9 parts of sodium dichloroisocyanurate, 2-4 parts of rosmarinic acid, 3-6 parts of octenidine, 1-2 parts of sodium hexametaphosphate, 1-3 parts of polyhexamethylene biguanide hydrochloride, 2-3 parts of potassium monopersulfate, 0.6-1.3 parts of potassium chloride, 0.8-1.5 parts of dialkyldimethylammonium chloride, 0.4-0.6 parts of laurocapram, 0.5-2 parts of squalane, 0.3-0.9 parts of carvacrol and 0.2-0.8 parts of benzalkonium chloride.

3. A chlorine-containing disinfectant according to claim 2, characterized in that: The chlorine-containing disinfectant comprises the following ingredients in parts by weight: 16-17 parts of bromochlorohydantoin, 7.5-8.5 parts of sodium dichloroisocyanurate, 2.2-3.5 parts of rosmarinic acid, 4.5-5 parts of octenidine, 1.2-1.8 parts of sodium hexametaphosphate, 2.3-2.7 parts of polyhexamethylene biguanide hydrochloride, 2.1-2.4 parts of potassium monopersulfate, 0.9-1.1 parts of potassium chloride, 1-1.2 parts of dialkyldimethylammonium chloride, 0.4-0.5 parts of laurocapram, 1.3-1.5 parts of squalane, 0.6-0.8 parts of carvacrol and 0.4-0.6 parts of benzalkonium chloride.

4. A chlorine-containing disinfectant according to claim 3, characterized in that: The chlorine-containing disinfectant comprises the following ingredients in parts by weight: 16.5 parts of bromochlorohydantoin, 8 parts of sodium dichloroisocyanurate, 2.8 parts of rosmarinic acid, 4.7 parts of octenidine, 1.6 parts of sodium hexametaphosphate, 2.4 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of potassium monopersulfate, 1 part of potassium chloride, 1.1 parts of dialkyldimethylammonium chloride, 0.45 parts of laurocapram, 1.4 parts of squalane, 0.7 parts of carvacrol and 0.5 parts of benzalkonium chloride.

5. A chlorine-containing disinfectant according to claim 3, characterized in that: The chlorine-containing disinfectant also includes 0.5-0.9 parts by weight of nano silicon dioxide.

6. A chlorine-containing disinfectant according to claim 3, characterized in that: The chlorine-containing disinfectant also includes 1.2 to 2 parts by weight of menthol.

7. A chlorine-containing disinfectant according to claim 3, characterized in that: The chlorine-containing disinfectant also includes 2 to 3 parts by weight of sodium hypochlorite.

8. A chlorine-containing disinfectant according to claim 3, characterized in that: The chlorine-containing disinfectant also includes 0.4-0.8 parts by weight of dibromocyanopropionamide.

9. A chlorine-containing disinfectant according to claim 3, characterized in that: The chlorine-containing disinfectant is composed of the following ingredients in parts by weight: 16.5 parts of bromochlorohydantoin, 8 parts of sodium dichloroisocyanurate, 2.8 parts of rosmarinic acid, 4.7 parts of octenidine, 1.6 parts of sodium hexametaphosphate, 2.4 parts of polyhexamethylene biguanide hydrochloride, 2.2 parts of potassium monopersulfate, 1 part of potassium chloride, 1.1 parts of dialkyldimethylammonium chloride, 0.45 parts of laurocapram, 1.4 parts of squalane, 0.7 parts of carvacrol, 0.5 parts of benzalkonium chloride, 0.8 parts of nano silicon dioxide, 1.6 parts of menthol, 2.5 parts of sodium hypochlorite and 0.6 parts of dibromocyanopropionamide.

10. The method for preparing the chlorine-containing disinfectant according to any one of claims 1 to 9, characterized in that: The following steps are involved: In a clean container, stir the formulated amounts of bromochlorohydantoin, sodium dichloroisocyanurate, rosmarinic acid, octenidine, sodium hexametaphosphate, and polyhexamethylene biguanide hydrochloride at room temperature for 30-35 minutes, then add 1.5 times the volume of deionized water, then add the formulated amounts of potassium monopersulfate, potassium chloride, and dialkyldimethylammonium chloride, adjust the temperature to 45-48°C, continue stirring for 1-2 hours, then adjust the pH to 8.3-8.5, add 0.2 times the volume of glycerol, then add the formulated amounts of laurocapram, squalane, carvacrol, and benzalkonium chloride, and stir for 1-1.5 hours.