A gastrointestinal tumor cell harvester

Abstract

The application relates to the technical field of cell sampling or biopsy, in particular to a digestive tract tumor cell collector. The collector comprises a device body, the device body at least comprises a connecting piece and an external connecting pipe which are connected in sequence, the external connecting pipe is detachably connected with the connecting piece, the connecting piece comprises a connecting table and a main shaft, the main shaft is arranged through the connecting table and is connected with a sampling assembly; a sliding groove is arranged on the connecting table, a feedback control assembly is slidably connected in the sliding groove, the feedback control assembly is electrically connected with the sampling assembly and the main shaft through wires, and the feedback control assembly feeds back and adjusts the main shaft. The application solves the problem that, due to the neglect of the convenience of the sampling process in the prior art, the operation time is too long, and the patient feels serious discomfort.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of cell sampling or biopsy, in particular, to a digestive tract tumor cell collector. BACKGROUND

[0002] Due to the use of fertilizers, pesticides, feed, additives and the like in the current food industry, health problems caused by food are becoming more and more serious, and digestive tract tumor is a highly prevalent disease. In the diagnosis and treatment of digestive tract tumor, digestive tract tumor cells need to be collected for laboratory analysis, which requires the use of a digestive tract tumor cell collector.

[0003] In the prior art, a Chinese utility model patent with publication number CN208799252U and the name of a digestive tract tumor cell collector was announced on April 30, 2019. It discloses a collector including an upper collector, a middle collector and a lower collector, wherein the outer side of the middle collector and the lower collector is covered with an elastic film. The elastic film is stretched into a rectangular shape, wrapped around the outer side of the middle collector or the lower collector, and then two edges are detachably connected together to form the elastic film. Although this structure can achieve cell collection, the convenience of the collection process still needs to be improved to avoid serious discomfort of the patient due to long operation time. SUMMARY

[0004] Therefore, the purpose of the present application is to provide a digestive tract tumor cell collector that optimizes the collection process of digestive tract tumor cells and solves the problem of long operation time and serious discomfort of the patient due to the neglect of the convenience of the collection process in the prior art.

[0005] According to one aspect of the present application, a digestive tract tumor cell collector is provided, in particular, a collector that quickly realizes the collection of digestive tract tumor cell samples, comprising: a device body, the device body at least including a connecting piece and an external connecting pipe connected in sequence, the external connecting pipe being detachably connected to the connecting piece, the connecting piece including a connecting table and a main shaft, the main shaft penetrating the connecting table and being connected with a sampling assembly; a sliding groove is formed in the connecting table, and a feedback control assembly is slidably connected in the sliding groove, the feedback control assembly being electrically connected to the sampling assembly and the main shaft through a wire, and the feedback control assembly feeds back to adjust the main shaft.

[0006] In some embodiments, the sampling assembly at least includes a scraping blade, a connecting column and a pressure touch sensor, one end of the connecting column being detachably connected to the scraping blade, and the other end being connected to the main shaft; the scraping blade is provided with a pressure touch sensor, and the pressure touch sensor is data-connected with the feedback control assembly. When the cells are collected and contact the surface of the pressure touch sensor, the pressure touch sensor transmits pressure touch information to the feedback control assembly.

[0007] In some embodiments, the feedback control assembly at least comprises a master control center, a drive shaft, a drive disc, a connecting rod, a connecting sleeve and a brake block arranged from top to bottom, wherein the master control center is connected with the drive shaft, the drive shaft is fixedly connected with the drive disc, the drive disc is fixedly connected with the connecting rod, the connecting rod is fixedly connected with the connecting sleeve, and the connecting sleeve is fixedly connected with the brake block.

[0008] In some embodiments, the connecting table is externally connected with a first camera, a second camera and a third camera, the first camera is arranged at intervals from the second camera, the second camera is arranged at intervals from the third camera, and the third camera is arranged at intervals from the first camera.

[0009] In some embodiments, the connecting table is electrically connected with a first light source, a second light source and a third light source, the first light source is arranged beside the first camera, the second light source is arranged beside the second camera, and the third light source is arranged beside the third camera.

[0010] In some embodiments, the connecting column is externally sleeved with an external sleeve, and a plurality of mesh holes for shielding foreign matters and ensuring air circulation are arranged at intervals on the circumferential surface of the external sleeve.

[0011] In some embodiments, the master control center is internally arranged with a first control unit and a data-connected second control unit, wherein the first control unit is electrically connected with the main shaft and controls the rotation of the main shaft, and the second control unit controls the brake block to lock the main shaft drive based on the pressure touch information of the pressure touch sensor.

[0012] In some embodiments, a pressure locking mechanism is connected between the main shaft and the brake block.

[0013] The technical scheme of the present application has at least the following advantages and beneficial effects: the present application quickly realizes the collection of tumor cell samples in the digestive tract through the sampling assembly and the feedback control assembly, optimizes the collection steps, greatly improves the convenience in the collection process, reduces the pain of patients, and cooperates with the master control center and the pressure touch sensor to realize accurate control of the sample collection amount and accurate regulation of the collection operation process. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 The structure schematic diagram of the collector provided by the present application is shown in the figure;

[0015] Figure 2 The structure schematic diagram of the connecting piece in the collector provided by the present application is shown in the figure;

[0016] Figure 3 Another structure schematic diagram of the connecting piece in the collector provided by the present application is shown in the figure;

[0017] Figure 4 The bottom view of the connecting table in the collector provided in the present application is shown in the figure.

[0018] Figure 5 Another structural schematic view of the connecting piece provided in the present application is shown in the figure.

[0019] In the figure: 1-connecting piece; 2-external connecting pipe; 3-connecting table; 4-main shaft; 5-sliding slot; 6-driving shaft; 7-scraping piece; 8-connecting column; 9-pressure touch sensor; 10-main control center; 11-driving disc; 12-connecting rod; 13-connecting sleeve; 14-brake block; 15-first camera; 16-second camera; 17-third camera; 18-wire; 19-first light source; 20-second light source; 21-third light source; 22-external connecting sleeve; 23-with mesh hole. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be described clearly and completely below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all the other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0021] EMBODIMENT

[0022] Please refer to Figures 1-5 The present application provides a digestive tract tumor cell collector, which comprises a device body, the device body at least comprises a connecting piece 1 and an external connecting pipe 2 connected in sequence, the external connecting pipe 2 is detachably connected to the connecting piece 1, the connecting piece 1 comprises a connecting table 3 and a main shaft 4, the main shaft 4 is arranged through the connecting table 3 and is connected with a sampling assembly; a sliding slot 5 is formed in the connecting table 3, a feedback control assembly is slidably connected in the sliding slot 5, the feedback control assembly is electrically connected to the sampling assembly and the main shaft 4 through a wire 18, and the feedback control assembly feeds back to adjust the main shaft 4.

[0023] It is worth mentioning that the connecting piece 1 and the external connecting pipe 2 are arranged, the connecting piece 1 is connected through the arranged external connecting pipe 2, the connecting piece 1 is convenient to send into the body or pull out of the body, the connecting piece 1 and the external connecting pipe 2 are convenient to install and disassemble through the detachable connection mode, the connecting piece 1 and the external connecting pipe 2 can be cleaned respectively when the connecting piece 1 or the external connecting pipe 2 needs to be cleaned, bacteria or pollutants are avoided to be left to cause the whole device to be unable to be normally used, and the patient is avoided to cause infection or secondary injury. In detail, the connecting piece 1 comprises the connecting table 3 and the main shaft 4 connected with each other, the sampling assembly is driven to rotate by controlling the rotation of the main shaft 4, and the sample collection is completed in the process of the rotation of the sampling assembly. When the sample is collected, that is, after the sampling assembly senses the sample adhesion and receives the specified pressure signal, the sampling assembly will transmit the collection signal or the pressure signal to the specified receiving end, and then control the feedback control assembly to start working. The feedback control assembly is driven and moves along the sliding groove 5, the feedback control assembly feeds back the main shaft 4, and then controls the main shaft 4 to be locked, that is, the main shaft 4 is not allowed to rotate, at this time the sampling assembly stops sample acquisition, the operator extracts the sampler body, and the sampling is completed.

[0024] The sampling assembly and the feedback control assembly are arranged in the embodiment, the collection of the tumor cell sample in the digestive tract is quickly realized, the collection step is optimized, the convenience degree in the collection process is greatly improved, the operation time is greatly reduced, the pain of the patient is reduced, the discomfort of the patient is reduced, and the problem that the operation time is too long in the prior art and the patient is seriously uncomfortable is solved.

[0025] Further, the sampling assembly at least comprises the scraping piece 7, the connecting column 8 and the pressure touch sensor 9, one end of the connecting column 8 is detachably connected with the scraping piece 7, and the other end is connected with the main shaft 4; the pressure touch sensor 9 is arranged on the scraping piece 7, and the pressure touch sensor 9 is in data connection with the feedback control assembly. When the cells are collected and contact the surface of the pressure touch sensor 9, the pressure touch sensor 9 will transmit the pressure touch information to the feedback control assembly.

[0026] The scraping piece 7, the connecting column 8 and the pressure touch sensor 9 are arranged in the embodiment, the adhesion and collection of the tumor cell sample in the digestive tract are realized through the rotation of the scraping piece 7, the scraping piece 7 is connected through the connecting column 8, and the rotation of the scraping piece 7 is driven through the rotation of the connecting column 8, and then the sample collection is completed. The pressure touch sensor 9 arranged on the scraping piece 7 can effectively and quickly judge whether the sample contacts the scraping piece 7, the invalid operation process is greatly reduced, and the discomfort of the patient is further effectively alleviated. In detail, the pressure touch sensor 9 is in data connection with the feedback control assembly. When the cells are collected and contact the surface of the pressure touch sensor 9, the pressure touch sensor 9 will transmit the pressure touch information to the feedback control assembly, and then the feedback control assembly quickly controls the main shaft 4, and the whole sample collection time is shortened.

[0027] Preferably, the scraper 7 is helical and coiled on the connecting column 8, so that the scraper 7 forms a helical working state during the rotation of the connecting column 8, and the sample contacted by the end of the scraper 7 is continuously moved upward and collected and protected due to the extrusion force of the front sample on the rear sample, thereby maximizing the number of collected samples and avoiding the complete falling of the samples during the entire device entering and exiting process, and avoiding the occurrence of invalid operation.

[0028] Further, the feedback control assembly at least includes a master control center 10, a drive shaft 6, a drive disc 11, a connecting rod 12, a connecting sleeve 13, and a brake block 14 arranged from top to bottom, wherein the master control center 10 is data-connected with the drive shaft 6, the drive shaft 6 is fixedly connected with the drive disc 11, the drive disc 11 is fixedly connected with the connecting rod 12, the connecting rod 12 is fixedly connected with the connecting sleeve 13, and the connecting sleeve 13 is fixedly connected with the brake block 14. The master control center 10, the drive shaft 6, the drive disc 11, the connecting rod 12, the connecting sleeve 13, and the brake block 14 are sequentially connected in this embodiment, the master control center 10 controls the rotation of the drive shaft 6, which in turn drives the rotation of the drive disc 11, the rotation of the connecting rod 12, the sliding of the connecting sleeve 13 in the sliding groove 5, and the sliding of the brake block 14 in the sliding groove 5, and the brake block 14 contacts the main shaft 4 after moving to the specified position and promotes the stop of the rotation of the main shaft 4.

[0029] Further, the connecting table 3 is externally connected with a first camera 15, a second camera 16, and a third camera 17, the first camera 15 is arranged at intervals with the second camera 16, the second camera 16 is arranged at intervals with the third camera 17, and the third camera 17 is arranged at intervals with the first camera 15. The connecting table 3 is electrically connected with a first light source 19, a second light source 20, and a third light source 21, the first light source 19 is arranged beside the first camera 15, the second light source 20 is arranged beside the second camera 16, and the third light source 21 is arranged beside the third camera 17. It should be noted that the first camera 15, the second camera 16, and the third camera 17 are arranged to acquire the situation in the digestive tract, the first light source 19, the second light source 20, and the third light source 21 are arranged to provide sufficient light for the first camera 15, the second camera 16, and the third camera 17, respectively, to ensure the normal work of the first camera 15, the second camera 16, and the third camera 17, and to make the entire sampler more visualized.

[0030] Further, the connecting column 8 is externally sleeved with an external sleeve 22, and a plurality of mesh holes 23 for shielding foreign matters and ensuring air circulation are arranged at intervals on the circumferential surface of the external sleeve 22.

[0031] It should be noted that by providing the outer sleeve 22 and extending the upper end of the spiral-shaped scraper 7 into it, the remaining substances in the digestive tract during the extraction process are isolated, and at the same time, the collected sample can enter the outer sleeve 22 along the spiral structure and be effectively protected, avoiding a large amount of falling during the process of the device in and out. By providing the mesh 23 on the outer sleeve 22, a certain amount of sample can be effectively discharged when the sample volume is too large, and it can also play an auxiliary role in ventilation.

[0032] Further, the main control center 10 is configured with a first control unit and a data-connected second control unit, wherein the first control unit is electrically connected to the main shaft 4 and controls the rotation of the main shaft 4, and the second control unit controls the brake block 14 to lock the main shaft 4 drive based on the pressure touch information of the pressure touch sensor 9.

[0033] It should be noted that the main control center 10 is configured with a first control unit and a second control unit, the first control unit is used to control the rotation of the main shaft 4, the second control unit receives the pressure touch information transmitted by the pressure touch sensor 9, and after receiving the pressure touch information, the brake block 14 starts to work to stop the rotation of the main shaft 4. In detail, the first control unit of the main control center 10 controls the rotation of the main shaft 4, drives the connecting column 8 to rotate, and the connecting column 8 drives the scraper 7 to collect samples. When the sample is collected, that is, the pressure touch sensor 9 senses the attachment of the sample, the pressure touch sensor 9 will transmit the pressure touch information to the second control unit of the main control center 10 to chain drive the brake block 14, and then drive the compression locking mechanism to lock the main shaft 4, that is, not to rotate. At this time, the scraper 7 stops sampling, the operator pulls out the sampler body, and the sampling is completed. Through the linkage cooperation between the sampling assembly, the feedback control assembly, the main control center 10, and the pressure touch sensor 9, the precise control of the sample collection amount and the precise regulation of the collection operation process are realized.

[0034] Further, the main shaft 4 and the brake block 14 are connected with a compression locking mechanism. By controlling the brake block 14 to start working, the brake block 14 drives the compression locking mechanism to lock the main shaft 4, and finally the main shaft 4 stops rotating.

[0035] In order to better understand the present application, a digestive tract tumor cell collection method is provided, comprising:

[0036] Step 1. Connect the outer pipe 2 to form the collector body;

[0037] Step 2. Manually send the collector body to the affected area of the digestive tract;

[0038] Step 3. Control the feedback control assembly and the sampling assembly to work;

[0039] Step 4. After obtaining the tumor cells, stop sampling.

[0040] So far, the embodiments of the present disclosure have been described in detail. In order to avoid obscuring the concept of the present disclosure, some details known in the art are not described. Those skilled in the art can fully understand how to implement the technical solutions disclosed herein according to the above description.

[0041] Although some specific embodiments of the present disclosure have been described in detail through examples, those skilled in the art should understand that the above examples are only for illustration, not for limiting the scope of the present disclosure. Those skilled in the art should understand that the above embodiments can be modified or some technical features can be replaced equivalently without departing from the scope and spirit of the present disclosure. The scope of the present disclosure is defined by the appended claims.

Claims

1. A digestive tract tumor cell collector, characterized in that, include: The device body includes at least a connector (1) and an outer tube (2) connected in sequence. The outer tube (2) is detachably connected to the connector (1). The connector (1) includes a connecting platform (3) and a main shaft (4). The main shaft (4) passes through the connecting platform (3) and is connected to a sampling component. A sliding groove (5) is provided on the connecting platform (3). A feedback control component is slidably connected in the sliding groove (5). The feedback control component is electrically connected to the sampling component and connected to the main shaft (4) through a wire (18). The component feedback adjusts the main shaft (4); the feedback control component includes at least a main control center (10), a drive shaft (6), a drive disk (11), a connecting rod (12), a connecting sleeve (13), and a brake block (14) arranged from top to bottom, wherein the main control center (10) is connected to the drive shaft (6), the drive shaft (6) is fixedly connected to the drive disk (11), the drive disk (11) is fixedly connected to the connecting rod (12), the connecting rod (12) is fixedly connected to the connecting sleeve (13), and the connecting sleeve (13) is fixedly connected to the brake block (14); The main control center (10) controls the drive shaft (6) to rotate, thereby sequentially driving the drive disc (11) to rotate and the connecting rod (12) to rotate. The connecting sleeve (13) slides in the slide groove (5), and the brake block (14) slides in the slide groove (5). After the brake block (14) moves to the designated position, it contacts the main shaft (4) and causes the main shaft (4) to stop rotating.

2. The data collector according to claim 1, characterized in that, The sampling component includes at least a scraper (7), a connecting post (8), and a pressure sensor (9). One end of the connecting post (8) is detachably connected to the scraper (7), and the other end is connected to the main shaft (4). The scraper (7) is equipped with a pressure sensor (9), which is data-connected to the feedback control component. When a cell comes into contact with the surface of the pressure sensor (9) after collection, the pressure sensor (9) will transmit pressure information to the feedback control component.

3. The data collector according to claim 1, characterized in that, The connecting platform (3) is externally connected to a first camera (15), a second camera (16) and a third camera (17). The first camera (15) is positioned at a distance from the second camera (16), the second camera (16) is positioned at a distance from the third camera (17), and the third camera (17) is positioned at a distance from the first camera (15).

4. The data collector according to claim 3, characterized in that, The connecting platform (3) is electrically connected to a first light source (19), a second light source (20) and a third light source (21). The first light source (19) is located next to the first camera (15), the second light source (20) is located next to the second camera (16), and the third light source (21) is located next to the third camera (17).

5. The data collector according to claim 2, characterized in that, The connecting column (8) is fitted with an outer sleeve (22) around its periphery. The outer sleeve (22) has at least one mesh hole (23) at intervals around its periphery to block foreign objects and ensure air circulation.

6. The data collector according to claim 2, characterized in that, The main control center (10) is equipped with a first control unit and a second control unit connected to the data connection. The first control unit is electrically connected to the spindle (4) and controls the spindle (4) to rotate. The second control unit controls the brake block (14) to perform locking drive based on the pressure information of the pressure sensor (9).

7. The data collector according to claim 6, characterized in that, A clamping and locking mechanism is connected between the main shaft (4) and the brake block (14).

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