Preparation method of extract granules containing Ningxia wolfberry fruits and Changbai wild ginseng
Through the method without auxiliary materials, the extract of wolfberry and Changbai Mountain wild ginseng was obtained by soaking and high-temperature extraction, and spray-dried in yam powder, which solved the problem of granulation difficulty and sugar increase caused by high sugar content of wolfberry, and achieved efficient preparation of particles and effective protection of neurons.
Patent Information
- Application Number
- CN202311629958.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-12-01
- Publication Date
- 2025-06-03
AI Technical Summary
In the prior art, when preparing extract particles of Ningxia wolfberry and Changbai Mountain wild ginseng, it is difficult to avoid the difficulty of the granulation process caused by high sugar content of wolfberry and the possible problems of obesity and blood sugar rise.
Using a method without auxiliary materials, the extract of wolfberry and Changbai Mountain wild ginseng was obtained through soaking and high temperature extraction, and spray-dried in yam powder, and yam was used as a molding agent and potential neuronal protection agent.
The efficient preparation of wolfberry extract particles is achieved, which avoids the problem of increasing sugar caused by the use of general auxiliary materials, and is easy to implement and effectively protects neurons.
Abstract
Description
Technical Field
[0001] The present invention relates to a method for preparing a neuro-healthcare product granule, and particularly to a method for preparing an extract granule comprising Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain. Background Art
[0002] Lycium barbarum is a traditional Chinese medicine that is both a medicine and a food in China. Among them, Lycium barbarum from Ningxia is a genuine medicinal material variety included in the Chinese Pharmacopoeia (2020 Edition). Pharmacological studies have shown that it has anti-inflammatory, antioxidant, and neuroprotective effects. With the increasing attention of people to health care and food therapy for health preservation, the quality evaluation of Lycium barbarum and the research on its medicinal effects have been increasing. Wild ginseng from Changbai Mountain tastes sweet and bitter, and is slightly warm in nature. It has the effects of greatly tonifying primordial qi, invigorating the spleen and benefiting the lungs, promoting the production of body fluids and nourishing blood, and calming the nerves and improving intelligence. Preparing the extracts of these two into granular health care products is beneficial to neuroprotection. During the preparation process, due to the relatively high sugar content of Lycium barbarum, the granulation process is quite difficult and prone to caking. If general excipients such as lactose, dextrin, starch, etc. are added to manufacture granules, long-term intake may cause obesity, and it is more likely to cause blood sugar to rise in diabetic patients. Summary of the Invention
[0003] The technical problem to be solved by the present invention is to propose a method for preparing an extract granule comprising Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain, which does not contain excipients and is easy to granulate, aiming at the above-mentioned defects of the prior art.
[0004] The technical solution adopted by the present invention to solve its technical problem is as follows: Provide a method for preparing granules of extracts of Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain, comprising the following steps: (1) Prepare raw materials, the raw materials include 30 - 90% by total weight of Lycium barbarum, 1 - 25% of wild ginseng from Changbai Mountain, and 5 - 50% of Chinese yam; (2) Take Lycium barbarum from Ningxia, soak it in pure water at 30 - 50 °C for about 5 to 35 minutes, then extract it at 85 - 100 °C for about 30 minutes to 2 hours, and take the extract; then extract it at 85 - 100 °C for 30 minutes to 2 hours, combine the two extracts and concentrate; (3) Take wild ginseng from Changbai Mountain, extract it with pure water at 85 - 100 °C for about 30 minutes to 2 hours, take the extract, then extract it at 85 - 100 °C for 30 minutes to 2 hours, combine the two extracts and concentrate; take the residue of wild ginseng from Changbai Mountain and dry it until the water content is about 5 - 15%, and granulate and grind it into powder of wild ginseng from Changbai Mountain; (4) Take Chinese yam, granulate and grind it into powder, and mix it with the powder of wild ginseng from Changbai Mountain obtained in step (3) to obtain a mixture of powder of wild ginseng from Changbai Mountain and Chinese yam; (5) Combine the wolfberry extract and the ginseng extract. Take the mixture of Changbai Mountain ginseng and Chinese yam powder, and spray the combined wolfberry extract and ginseng extract onto the mixture of Changbai Mountain ginseng and Chinese yam powder to obtain granules of Ningxia wolfberries and extracts of Changbai Mountain wild ginseng.
[0005] Further: The residue of Changbai Mountain ginseng is granulated and ground to 40 - 80 mesh, and the Chinese yam is granulated and ground to 40 - 80 mesh.
[0006] In steps (2) and (3), the extract is concentrated to a relative concentration of 1 - 2 g / ml.
[0007] Use a fluidized bed spray drying device to spray the combined extracts of wolfberries and ginseng onto the mixture of Changbai Mountain ginseng and Chinese yam powder.
[0008] Fill the granules of Ningxia wolfberries and extracts of Changbai Mountain wild ginseng into capsules.
[0009] The present invention prepares granules using extracts of Ningxia wolfberries, Changbai Mountain wild ginseng, and Chinese yam as raw materials, and uses Chinese yam instead of excipients as a potential neuron protectant. Compared with the prior art, the present invention has the following beneficial effects: Using the Chinese yam in the formula as a granulating agent and replacing the existing common excipients with Chinese yam, Chinese yam not only has the effect of invigorating the spleen itself, but also the Chinese yam powder is easy to absorb the extract. When the medicinal liquid is sprayed onto the Chinese yam powder, the active ingredients can be loaded onto the Chinese yam powder. The sugar content of wolfberries is relatively high, and spraying onto Chinese yam is more efficient than ordinary excipients, avoiding the risk of increasing blood sugar rise and being easy to implement. Embodiment
[0010] Now, a detailed description of the preferred embodiments of the present invention is given.
[0011] A method for preparing granules of extracts of Ningxia wolfberries and Changbai Mountain wild ginseng includes the steps: (1) Prepare raw materials, including 30 - 90% of wolfberries, 1 - 25% of Changbai Mountain wild ginseng, and 5 - 50% of Chinese yam by total weight; (2) Take Ningxia wolfberries, soak them in pure water at 30 - 50 °C for about 5 to 35 minutes, then extract at 85 - 100 °C for about 30 minutes to 2 hours, and take the extract; then extract at 85 - 100 °C for 30 minutes to 2 hours, combine the two extracts, and concentrate to a relative concentration of 1 - 2 g / ml; (3)Take wild ginseng from Changbai Mountain, extract it with pure water at 85 - 100°C for about 30 minutes to 2 hours, take the extract, and then extract it at 85 - 100°C for 30 minutes to 2 hours. Combine the two extracts and concentrate them to a relative concentration of 1 - 2 g / ml; take the medicinal residue of Changbai Mountain ginseng and dry it until the moisture content is about 5 - 15%, granulate and grind it to about 40 - 80 mesh to obtain Changbai Mountain ginseng powder. (4)Take Chinese yam, granulate and grind it to about 40 - 80 mesh to form powder, and mix it with the Changbai Mountain ginseng powder obtained in step (3) to obtain a mixture of Changbai Mountain ginseng and Chinese yam powder. (5)Combine the wolfberry extract and ginseng extract. Take the mixture of Changbai Mountain ginseng and Chinese yam powder. Using a fluidized bed spray drying device, spray the combined wolfberry extract and ginseng extract onto the mixture of Changbai Mountain ginseng and Chinese yam powder to obtain granules of Ningxia wolfberry and wild ginseng extract from Changbai Mountain. The granules of Ningxia wolfberry and wild ginseng extract from Changbai Mountain can be filled into capsules.
[0012] Wolfberry is a traditional Chinese medicine that is both a medicine and a food in China. Among them, Ningxia wolfberry is a genuine medicinal material variety included in the 2020 edition of the Chinese Pharmacopoeia. Pharmacological studies have shown that it has anti - inflammatory, antioxidant and neuroprotective effects. Wild ginseng from Changbai Mountain tastes sweet and bitter, and is slightly warm in nature. It has the effects of greatly tonifying primordial qi, invigorating the spleen and benefiting the lungs, promoting fluid production and nourishing blood, and calming the mind and improving intelligence. Chinese yam tastes sweet and is neutral in nature, and has the effects of invigorating the spleen and nourishing the stomach, promoting fluid production and benefiting the lungs, and tonifying the kidney and astringing essence. When the three are combined, in addition to having anti - inflammatory, antioxidant and neuroprotective effects, they can also tonify primordial qi and strengthen the spleen and stomach.
[0013] This patent prepares granules using the extracts of Ningxia wolfberry, wild ginseng from Changbai Mountain and Chinese yam as raw materials, and uses Chinese yam instead of excipients as a potential neuron protectant. Using Chinese yam powder, one of the raw materials in the formula, as a granulating agent not only has the effect of strengthening the spleen, but also is easy to absorb the medicinal liquid. When the medicinal liquid is sprayed onto the Chinese yam powder by spray drying technology, the active ingredients can be loaded onto the Chinese yam powder more efficiently and is easy to implement. Because wolfberry has a relatively high sugar content, the granulation process is more difficult and it is easy to agglomerate. If general excipients such as lactose, dextrin, starch, etc. are added to make granules, long - term intake may cause obesity, and it is more likely to cause blood sugar to rise in diabetic patients. Using Chinese yam to replace excipients such as lactose, dextrin, starch, etc. overcomes the problem of increased sugar powder caused by using general excipients, and people taking it can avoid non - prescription sugar or other substances.
[0014] It should be understood that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. For those skilled in the art, the technical solutions recorded in the above embodiments can be modified, or some of the technical features can be equivalently replaced; and these modifications and replacements should all fall within the protection scope of the appended claims of the present invention.
Claims
1. A method for preparing extract granules comprising Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain, characterized in that: It includes the steps: (1) Prepare raw materials, the raw materials include 30-90% of Lycium barbarum by total weight, 1-25% of wild ginseng from Changbai Mountain, and 5-50% of Chinese yam; (2) Take Lycium barbarum from Ningxia, soak it in pure water at 30-50 °C for about 5 to 35 minutes, then extract at 85-100 °C for about 30 minutes to 2 hours, and take the extract; then extract at 85-100 °C for 30 minutes to 2 hours, combine the two extracts and concentrate; (3) Take wild ginseng from Changbai Mountain, extract it with pure water at 85-100 °C for about 30 minutes to 2 hours, take the extract, then extract at 85-100 °C for 30 minutes to 2 hours, combine the two extracts and concentrate; Take the residue of Changbai Mountain ginseng and dry it until the moisture content is about 5-15%, and granulate and grind it into Changbai Mountain ginseng powder; (4) Take Chinese yam, granulate and grind it into powder, and mix it with the Changbai Mountain ginseng powder obtained in step (3) to form a mixture of Changbai Mountain ginseng and Chinese yam powder; (5) Combine the Lycium barbarum extract and the ginseng extract, take the mixture of Changbai Mountain ginseng and Chinese yam powder, and spray the combined Lycium barbarum extract and ginseng extract onto the mixture of Changbai Mountain ginseng and Chinese yam powder to obtain granules of Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain.
2. The method for preparing extract granules comprising Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain according to claim 1, characterized in that: The residue of Changbai Mountain ginseng is granulated and ground to 40-80 mesh, and the Chinese yam is granulated and ground to 40-80 mesh.
3. The method for preparing extract granules comprising Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain according to claim 1, characterized in that, In steps (2) and (3), the extract is concentrated to a relative concentration of 1-2 g / ml.
4. The method for preparing extract granules comprising Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain according to claim 1, characterized in that: Use a fluidized bed spray drying device to spray the combined extracts of Lycium barbarum and ginseng onto the mixture of Changbai Mountain ginseng and Chinese yam powder.
5. The method for preparing extract granules comprising Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain according to claim 1, characterized in that: Fill the granules of Lycium barbarum from Ningxia and wild ginseng from Changbai Mountain into capsules.