Dry powder medicament inhaler with built-in buccal device dispersing unit

Abstract

The invention relates to a dry powder medicament inhaler with a built-in buccal device dispersing unit, and belongs to the technical field of medical instruments. Comprising an inhaler body with a buccal device, the buccal device is internally provided with a dispersion unit, and the dispersion unit comprises a first elastic grid and a second elastic grid which define an inlet and an outlet of the dispersion unit; the plurality of elastic depolymerization sheets are arranged between the first elastic grid and the second elastic grid; a vibration inducing structure associated with an end anchor point of the elastic depolymerization sheet; the vibration inducing structure is configured to generate vibration in response to a portion of the suction airflow and transmit the vibration to the elastic depolymerization sheet through the anchor point. The dispersing unit aims to partially convert airflow energy generated by inhalation of a patient into mechanical energy and hydrodynamic energy which are used for overcoming acting force among dry powder medicament particles, so that dry powder medicament aggregates are effectively dispersed.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to a dry powder inhaler with a built-in mouthpiece dispersion unit. Background Art

[0002] A dry powder inhaler is a dry powder drug delivery device widely used in the treatment of respiratory diseases (such as asthma, chronic obstructive pulmonary disease, etc.). Compared with traditional metered-dose inhalers, dry powder inhalers usually do not contain propellants and rely on the patient's own inspiratory airflow as the driving force to carry a predetermined dose of dry powder drug out of the device and inhale it into the lungs, having advantages such as portability and relatively convenient use.

[0003] During the dry powder drug delivery process, one challenge is to ensure that the dry powder drug can reach the deep part of the lungs in the form of sufficiently fine particles (usually with an aerodynamic particle size less than 5 microns) to achieve the best therapeutic effect. However, the dry powder drug micropowders for inhalation therapy themselves have a very large specific surface area and surface energy, and there are strong van der Waals forces, electrostatic forces, and possibly liquid bridge forces (when there is moisture) between the particles, resulting in these fine dry powder drug particles being extremely prone to aggregating with each other to form larger aggregates or lumps during production, storage, and especially during inhalation delivery. Even for formulations mixed with a carrier (such as lactose), the dry powder drug micropowders need to effectively detach from the carrier surface and depolymerize themselves. Summary of the Invention

[0004] To solve the above problems in the prior art, the present invention provides a dry powder inhaler with a built-in mouthpiece dispersion unit.

[0005] To achieve the above object, the technical solution adopted by the present invention is: Provide a dry powder inhaler with a built-in mouthpiece dispersion unit, including an inhaler body with a mouthpiece, and a dispersion unit is arranged in the mouthpiece, and the dispersion unit includes: A first elastic grid and a second elastic grid that define the inlet and outlet of the dispersion unit, and the first elastic grid and the second elastic grid allow air flow and drug to pass through; A plurality of elastic depolymerization sheets arranged between the first elastic grid and the second elastic grid; Wherein, at least a part of the elastic depolymerization sheet has a triangular cross-section, and the elastic depolymerization sheet is arranged such that the edge of its triangular cross-section faces the inlet of the dispersion unit; A vibration induction structure associated with the end anchor points of the elastic depolymerization sheet; Wherein, the vibration induction structure is configured to be able to generate vibration in response to a part of the inhaled air flow and transmit the vibration to the elastic depolymerization sheet through the anchor points, so that the elastic depolymerization sheet vibrates during inhalation.

[0006] Preferably, the dispersion unit further includes: At least one purge channel; Wherein, the purge channel is configured to guide a part of the inhaled air flow to flow tangentially through at least one windward surface of the elastic disintegration sheet.

[0007] Preferably, the purge channel has: At least one slit-shaped outlet; Wherein, the slit-shaped outlet is arranged adjacent to the windward surface of the elastic disintegration sheet.

[0008] Preferably, the dispersion unit further includes: At least one air flow guiding cavity arranged at the anchor point position of the elastic disintegration sheet; Wherein, the vibration inducing structure is associated with the air flow guiding cavity and generates vibration in the air flow guiding cavity by receiving the part of the inhaled air flow; And, the air flow guiding cavity has at least one outlet, and the outlet constitutes the slit-shaped outlet of the purge channel.

[0009] Preferably, the vibration inducing structure includes an extended part of the elastic disintegration sheet itself outside the anchor point, and the extended part is configured to flutter under the action of a part of the inhaled air flow.

[0010] Preferably, the extended part has: At least one tuning block; Wherein, the tuning block is located at the end of the extended part, and the mass of the tuning block is greater than the unit length mass of the main body part of the elastic disintegration sheet.

[0011] Preferably, the end of the extended part has a serrated edge, and the thickness of the area of the serrated edge is less than the thickness of its area near the anchor point.

[0012] Preferably, the first elastic grid defines a plurality of grid openings; And, at least a part of the grid openings are arranged obliquely with respect to the central axis of the mouthpiece; In the flowing direction of the inhaled air flow, the first elastic grid is located upstream of the elastic disintegration sheet.

[0013] Preferably, the inhaler body includes: A cartridge for accommodating a single dose of medicament; Wherein, the cartridge has a medicament outlet channel, and the medicament outlet channel is communicated with the mouthpiece; And, at the periphery of the medicament outlet passage, at least one main air flow cavity is provided, and the main air flow cavity has a main air flow port communicating with the mouthpiece.

[0014] Preferably, the inhaler body includes: A medicament release mechanism integrated on the inhaler body and cooperating with the cartridge; The medicament release mechanism is used to puncture the single-dose medicament.

[0015] The present invention provides a dry powder medicament inhaler with a built-in mouthpiece dispersion unit. The beneficial effects of the present invention are reflected in: A dispersion unit is provided in the internal air flow passage of the mouthpiece. The dispersion unit is designed to partially convert the air flow energy generated by the patient's inhalation into mechanical energy and hydrodynamic energy for overcoming the interaction force between dry powder medicament particles, thereby effectively dispersing the dry powder medicament aggregates. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 FIG. is a perspective view of the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention; Figure 2 FIG. is a cross-sectional view of the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention; Figure 3 FIG. is a perspective view of the first elastic grid in the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention; Figure 4 FIG. is a perspective view of the elastic depolymerization sheet in the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention; Figure 5 FIG. is a schematic structural view of the dispersion unit in the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention; Figure 6 FIG. is a schematic structural view of the medicament outlet passage and the main air flow port in the dry powder medicament inhaler with a built-in mouthpiece dispersion unit proposed by the present invention.

[0017] DESCRIPTION OF THE REFERENCE NUMERALS 1. Inhaler body; 2. Mouthpiece; 3. Dispersion unit; 301. First elastic grid; 302. Second elastic grid; 303. Elastic depolymerization sheet; 3031. Windward surface; 3041. Slit-shaped outlet; 305. Anchor point; 306. Air flow guiding cavity; 4. Vibration induction structure; 401. Extension part; 402. Tuning block; 5. Single-dose medicament; 6. Cartridge; 601. Medicament outlet passage; 7. Main air flow cavity; 701. Main air flow port; 8. Medicament release mechanism. DETAILED DESCRIPTION OF THE INVENTION

[0018] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0019] Please refer to Figures 1-6 as shown below, the specific embodiments provided by the present invention are as follows: As Figures 1 to 2 shown, this embodiment provides a dry powder inhaler with a built-in mouthpiece 2 and a dispersion unit 3. This inhaler is used to deliver dry powder medicaments to the respiratory tract of a patient, especially deep into the lungs, to treat respiratory diseases such as asthma or chronic obstructive pulmonary disease.

[0020] The inhaler includes an inhaler body 1 and a mouthpiece 2. The inhaler body 1 constitutes the main part of the device, and its overall shape can be various shapes that are convenient for holding and operating, such as a flat oval cylinder, a cylinder, or a specific holding area with an ergonomic curve. This body is preferably made of one or more rigid medical-grade plastics through processes such as injection molding to provide sufficient structural strength and stability.

[0021] On the outer surface of the inhaler body 1, there are structures for internal mechanism linkage or display.

[0022] For example, it includes an installation position or opening for an operation button or slider for starting dose preparation or release, or a transparent window for observing the remaining dose. One end of the inhaler body 1 is formed into a mating interface specifically for connecting with the mouthpiece 2.

[0023] The mouthpiece 2 is the part that the patient directly contacts and inhales the dry powder medicament from. The mouthpiece 2 is generally tubular, or is in a flat duckbill shape for better fitting the oral cavity. One end (connection end) of the mouthpiece 2 has a connection structure that matches the mating interface of the inhaler body 1, such as a snap structure or a threaded structure, so that the mouthpiece 2 can be easily installed on or detached from the inhaler body 1.

[0024] Of course, the mouthpiece 2 can also be integrally formed with the body. The mouthpiece 2 is preferably made of a smooth and biocompatible medical-grade plastic. The other end (inhalation end) is formed into a mouthpiece part with a specific contour that is convenient for the patient to hold in the mouth and finally leads to a dry powder medicament outlet, and the shape of this outlet can be circular, oval, or other shapes suitable for dry powder medicament spraying.

[0025] Inside the mouthpiece 2, a central air flow channel is defined. The central air flow channel connects the air flow inlet of the inhaler body 1 (where the air flow carrying the dry powder medicament enters) to the final dry powder medicament outlet. Additionally, the outside of the mouthpiece 2 can optionally be equipped with a protective cap for covering the nozzle part when not in use to keep it clean and hygienic.

[0026] In this embodiment, a dispersion unit 3 is provided in the central air flow channel of the mouthpiece 2. The dispersion unit 3 is designed to partially convert the air flow energy generated by the patient's inhalation into mechanical energy and hydrodynamic energy for overcoming the interaction force between dry powder medicament particles, thereby effectively dispersing the dry powder medicament aggregates.

[0027] As Figures 2 to 5 shown, specifically, the inlet and outlet of the dispersion unit 3 are clearly defined by the first elastic grid 301 and the second elastic grid 302. The first elastic grid 301 and the second elastic grid 302 are preferably made of an elastic material with good biocompatibility and resilience, and both themselves present a porous network structure, ensuring that the main air flow and dry powder medicament particles can pass through with relatively low resistance, while forming the upper and lower boundaries of the core depolymerization region. And their elastic properties also allow them to produce a certain passive response to air flow pulsation.

[0028] As Figures 2 to 5 shown, between the first elastic grid 301 and the second elastic grid 302 is the core space where the depolymerization occurs, in which a number of independent elastic depolymerization sheets 303 are arranged. The elastic depolymerization sheet 303 is also made of an elastic material and has flexibility and fatigue resistance.

[0029] In addition, on the above basis, the elastic depolymerization sheet 303 has a triangular cross-section. When installed, the elastic depolymerization sheet 303 is positioned such that a sharp edge of its triangular cross-section faces the inlet of the dispersion unit 3, directly facing the incoming air flow carrying the dry powder medicament. The sharp edge is designed to produce an initial and concentrated interaction with the incoming air flow and the dry powder medicament aggregates therein, including physical cutting, inducing air flow separation, or generating specific local eddies. The two inclined sides constituting the edge, namely the windward surface 3031, guide the air flow and particles and provide the main interaction surface.

[0030] Specifically, when the dry powder medicament (especially the larger medicament aggregates therein) moves with the main air flow and collides with the two inclined windward surfaces 3031 of the elastic depolymerization sheet 303, at the moment of collision, the kinetic energy carried by the medicament aggregates will be transferred to the particles constituting the aggregates and their connection structures. When the impact energy is sufficient to overcome the binding force between the particles (such as van der Waals force, electrostatic force), it will cause the structure of the aggregates to be damaged or fragmented, directly decomposing them into several smaller units or single particles.

[0031] In addition, since the windward surface 3031 is inclined rather than a plane perpendicular to the oncoming flow direction, this kind of collision is closer to an oblique impact. This causes the dry powder medicament particles or the fragments of the broken aggregates to change their original movement trajectories after the collision, being directed to the side or continuing to move downstream at different angles, rather than simply bouncing vertically. This deflection and scattering helps to initially disperse the originally concentrated medicament aggregates spatially, increasing the surface area for the subsequent airflow to act on them and potentially reducing the probability of the particles colliding and aggregating again within a short distance downstream.

[0032] In a specific embodiment, in order to drive these elastic disaggregation sheets 303 to perform effective disaggregation work, their two ends are firmly fixed to the cavity wall of the dispersion unit 3 or the edges of the first elastic grid 301 and the second elastic grid 302 through anchor points 305 (which should be understood as a fixed connection point). And, at or in a position closely associated with these end anchor points 305, a vibration induction structure 4 is provided.

[0033] Specifically, the vibration induction structure 4 is used to utilize the energy of a part of the inhaled airflow guided here. When the patient inhales, a part of the airflow drives the vibration induction structure 4 to generate minute mechanical vibrations on its own. Since there is a fixed connection between the elastic disaggregation sheet 303 and the vibration induction structure 4, the vibration energy generated by the vibration induction structure 4 can be efficiently and directly transmitted to the elastic disaggregation sheet 303.

[0034] Therefore, during the entire inhalation period, the elastic disaggregation sheet 303 with a triangular cross-section will passively receive the drive from the anchor point 305 and accordingly undergo continuous minute vibrations along its length. When the airflow carrying the dry powder medicament aggregates enters the area composed of multiple elastic disaggregation sheets 303 through the first elastic grid 301, it will have repeated and multi-angle mechanical collisions with the slightly vibrating elastic sheets. Thus, the dry powder medicament aggregates are effectively broken up and disaggregated into fine particles suitable for pulmonary deposition, and then leave the dispersion unit 3 through the second elastic grid 302 along with the main airflow and are finally inhaled by the patient.

[0035] In a specific embodiment, after each elastic disaggregation sheet 303 is fixedly connected to the cavity wall of the dispersion unit 3 or the first elastic grid 301 and the second elastic grid 302 through the end anchor point 305, its structure does not terminate but continues to extend outward integrally, forming a cantilevered extension part 401. This extension part 401 and the main body of the elastic disaggregation sheet 303 are made of the same medical-grade elastic material with specific elastic modulus and damping characteristics.

[0036] To drive the extension part 401, an air flow guiding cavity 306 is provided inside the inhaler body 1 or in the dispersion unit 3. When the patient inhales, the air flow guiding cavity 306 captures a part of the inhaled air flow and guides it to the area where these extension parts 401 are located, so that the air flow acts on them at a preset angle and speed.

[0037] When the air flow speed acting on the extension part 401 reaches its flutter critical speed, due to the coupling effect among fluid force, elastic force and inertial force, the extension part 401 will enter the aeroelastic flutter state, manifested as continuous and rapid reciprocating vibration.

[0038] The vibration generated by this extension part 401 is transmitted through the root part and the anchor point 305 area connected to the main body of the elastic depolymerization sheet 303. The structure of this connection area is constructed to be conducive to the effective transmission of vibration energy and minimize damping loss. For example, it has a flexible neck or transition section with lower stiffness. Therefore, the flutter motion of the extension part 401 can drive the main body part of the elastic depolymerization sheet 303 to vibrate accordingly, and then disperse the dry powder medicament aggregates passing through the dispersion unit 3.

[0039] Wherein, at its free end, that is, the farthest end away from the anchor point 305 and cantilevered out, at least one tuning block 402 is integrally or additionally provided on the extension part 401 to make the extension part 401 have a concentrated mass.

[0040] Specifically, the end area of the extension part 401 can be set to be thicker and wider than its root part or middle part to form a geometric mass concentration area; or, during manufacturing, through processes such as two-color injection molding and insert molding, the end tuning block 402 part can be made of another biocompatible material with a density higher than the elastic material used for the main body of the extension part 401; or, the effective mass of the tuning block 402 is greater than the unit length mass of the main body part of the elastic depolymerization sheet 303, so as to ensure the formation of an effective inertial load.

[0041] Based on this, the extension part 401 is more easily excited by a lower speed air flow and more easily coupled with the aerodynamic force to generate flutter, thereby reducing the critical inhalation air flow speed for flutter to occur. This means that even if the patient's inhalation force is slightly weak, the vibration can be more reliably excited.

[0042] In another embodiment, the extension part 401 of the elastic depolymerization sheet 303 is not a smooth or straight edge at its free end, but is configured to have a serrated edge. This serrated edge can be embodied as a series of tiny tooth-like protrusions with a specific contour arranged along the end edge, such as triangular teeth, square teeth or wavy teeth, etc. The existence of these serrations changes the way the air flow peels off from the surface of the extension part 401 to promote its flutter behavior.

[0043] Meanwhile, this embodiment also defines that the end region of the extension part 401 includes a serrated edge, and its thickness is less than the thickness of the extension part 401 near its root (i.e., the position near the anchor point 305 region). That is to say, the serrated edge presents a thickness distribution that gradually thins from the root to the tip. Thus, the thickness reduction makes the end of the extension part 401 softer, reduces its ability to resist bending deformation, makes it more sensitive to the action of the air flow, helps to reduce the critical air flow velocity at which flutter occurs, and enables vibration to be started under weaker inhalation conditions.

[0044] In another embodiment, in order to address the problem that dry powder medicament may deposit or adhere inside the dispersion unit 3 during use, thereby affecting the dosing accuracy and long-term use performance, in this embodiment, the dispersion unit 3 further includes at least one purge channel.

[0045] The purge channel is a specific air flow path integrated in the cavity (such as the side wall) of the dispersion unit 3. It is connected to the inhalation air flow source (such as the aforementioned air flow guiding cavity 306) through an internal pipeline. When the patient inhales, a part of the inhalation air flow will be guided into the purge channel. Among them, the inhalation air flow blows onto at least one windward surface 3031 of the elastic disintegration sheet 303 in a manner that is substantially parallel to the surface of the elastic disintegration sheet 303 and flows tangentially (i.e., the two inclined surfaces in the triangular cross-section that face the entrance of the dispersion unit 3). This tangential purge air flow forms a continuously flowing weak air film or air curtain near the windward surface 3031 of the elastic disintegration sheet 303. For a small number of particles that have already adhered or are about to adhere, this tangential air flow close to the surface can effectively strip or blow them away, enabling them to re-enter the mainstream air flow or be carried out of the device.

[0046] As Figure 5 shown, in addition, in a specific embodiment, the outlet of the purge channel is preferably at least one slit-shaped outlet 3041. The slit-shaped outlet 3041 can generate a flat and uniform air flow, and its position is set next to the windward surface 3031 of the elastic disintegration sheet 303, ensuring that the purge air flow can effectively cover the target surface area.

[0047] In some embodiments, the function of the purge channel can be realized through the outlet of the air flow guiding cavity 306. That is, the air flow used to drive the vibration induction structure 4 directly discharges from the position that constitutes the slit-shaped outlet 3041 of the purge channel after leaving the air flow guiding cavity 306, realizing the reuse of the air flow and the integration of functions.

[0048] In some other embodiments, it is also possible to consider using a row of tiny, directionally arranged spray holes to replace the single slit, and covering the surface through the combination of multiple small air jets. The edges of the outlet can be chamfered or specially shaped to reduce the air flow separation, so that the ejected air flow can more stably adhere to the surface of the elastic sheet and flow.

[0049] In summary, by adding a purge channel in the dispersion unit 3 and using a part of the inhaled air flow to continuously tangentially purge the surface of the elastic depolymerization sheet 303, the drug residue can be significantly reduced, the cleanliness and efficient working state of the depolymerization element can be maintained, thereby improving the accuracy, consistency and effectiveness of the delivery dose of the entire inhaler.

[0050] In a specific embodiment, the first elastic grid 301 located at the inlet of the dispersion unit 3 is made of an elastic material and defines a plurality of grid openings for the air flow and the dry powder medicament to pass through. And at least a part of these grid openings, preferably most or all of them, do not penetrate perpendicularly to the grid plane, but are inclined with respect to the central axis of the mouthpiece 2 or the main air flow channel (i.e., the general inhaled air flow direction). This inclination can be achieved in various ways. For example, the channel walls of the grid openings themselves are inclined, or the grid bars forming the grid are inclined.

[0051] Furthermore, the grid can be divided into different regions, and the openings in each region have specific and uniform inclination angles and directions, but the angles / directions between the regions are different.

[0052] Or, the inclination directions of all the openings point to the center or to the outer periphery to produce a converging or diverging air flow effect.

[0053] Or, the inclination directions of the openings are arranged tangentially to induce an overall rotating air flow (swirl flow) downstream.

[0054] Thus, the air flow jets ejected from different angles and directions will interact, mix and shear with each other, thereby generating a stronger and more complex turbulent field at the entrance of the region where the elastic depolymerization sheet 303 is located than that of the straight-hole grid, which helps to perform preliminary dispersion before the dry powder medicament contacts the elastic sheet.

[0055] And through a specific inclined arrangement (such as generating a swirl flow), the overall air flow pattern entering the core region can be shaped so that it can more effectively interact with the vibrating elastic depolymerization sheet 303, improving the depolymerization efficiency or the distribution of particles in the cavity.

[0056] In this embodiment, to accommodate the use of a single-dose medicament 5 (such as a dry powder medicament pre-filled in a capsule), a cartridge 6 is provided inside the inhaler body 1. The size and shape of this cartridge 6 are for accommodating and positioning a single-dose medicament unit, such as a standard inhalation capsule. The cartridge 6 is usually equipped with corresponding mechanisms (such as a movable lid or drawer structure not shown in the figure) to facilitate the user to load or remove the single-dose medicament 5 unit.

[0057] As Figure 1 , Figure 2 and Figure 6 shown, a medicament outlet passage 601 is led out from the top of the cartridge 6. This medicament outlet passage 601 is the only path for the drug powder to leave the cartridge 6 and be guided towards the mouthpiece 2 after the medicament unit is activated (such as the capsule being punctured). The end of this medicament outlet passage 601 is in communication with the connecting end of the mouthpiece 2.

[0058] Around the peripheral side (circumferential side) of the medicament outlet passage 601, at least one (usually two symmetrically arranged or in a ring shape) main air flow cavity 7 is also provided inside the inhaler body 1. The main air flow cavity 7 occupies the part of the internal space outside the medicament outlet passage 601 and is in communication with the main air inlet provided outside the inhaler body 1. This means that when the patient inhales, the main inhaled air flow passes through the main air flow cavity 7, rather than directly passing through the cartridge 6 where the medicament is located.

[0059] Each main air flow cavity 7 also has a main air flow port 701 leading to the mouthpiece 2. The main air flow port 701 is also in communication with the connecting end of the mouthpiece 2.

[0060] Preferably, the main air flow port 701 is inclined towards the medicament outlet passage 601.

[0061] Separating the medicament outlet passage 601 and the main air flow port 701 inside the inhaler body 1 enables the main inhaled air flow to maintain a relatively high flow rate and energy, for effectively mixing, impinging and preliminarily dispersing with the dry powder medicament flow sucked out from the medicament outlet passage 601 at the entrance of the mouthpiece 2, and then entering the dispersion unit 3 provided downstream inside the mouthpiece 2 for further processing together.

[0062] To effectively release the single-dose medicament 5 (usually referring to a medicament capsule in this embodiment) accommodated in the cartridge 6 during use, the inhaler body 1 further includes a medicament release mechanism 8 that is functionally coordinated with and integrated thereon.

[0063] This medicament release mechanism 8 is used to puncture the outer shell (such as the capsule wall) of the single-dose medicament 5 so that the internal dry powder medicament can flow out smoothly during subsequent inhalation.

[0064] In a specific embodiment, the medicament release mechanism 8 includes the following structure: At least one (usually two or more, such as symmetrically arranged on both sides of the capsule) sharp needle disposed on the side or end of the cartridge 6. The needle is mounted on a movable bracket and is connected to a user operation button provided on the housing of the inhaler body 1 through a mechanical structure such as an internal link or a cam.

[0065] In the initial state or after loading a new single-dose medicament 5, the needle is in a retracted position away from the interior of the cartridge 6. When the user needs to inhale the drug and presses the operation button, the operating force drives the needle to move towards the center of the cartridge 6 through an internal transmission mechanism, and its tip penetrates a specific area of the cartridge 6 (provided with a hole for penetration) and pierces the shell of the single-dose medicament 5 (capsule) placed therein. After piercing, when the button is released or at the end of the button stroke, the needle will automatically retract (due to the elastic action of the spring) to avoid obstructing the outflow of the dry powder medicament and leave an opening of sufficient size on the capsule wall.

[0066] Through the action of the medicament release mechanism 8, the originally enclosed single-dose medicament 5 is opened, so that the dry powder medicament inside it can be carried out by the airflow from the cartridge 6 through the medicament outlet channel 601 when the patient inhales, and enter the subsequent disaggregation and inhalation process.

[0067] In the description of the embodiments of the present invention, it should be understood that the orientation or positional relationships indicated by the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "center", "top", "bottom", "top portion", "bottom portion", "inner", "outer", "inner side", "outer side", etc.

[0068] In the description of the embodiments of the present invention, it should be noted that unless otherwise clearly specified and limited, the terms "mounted", "connected", "connected", "assembled" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0069] In the description of the embodiments of the present invention, specific features, structures, materials, or characteristics can be combined in a suitable manner in any one or more embodiments or examples.

[0070] In the description of the embodiments of the present invention, it should be understood that "-" and "~" represent the range between two numerical values, and this range includes the endpoints. For example: "A - B" represents a range greater than or equal to A and less than or equal to B. "A ~ B" represents a range greater than or equal to A and less than or equal to B.

[0071] In the description of the embodiments of the present invention, the term "and / or" herein is merely a description of the association relationship of associated objects, indicating that three relationships may exist. For example, A and / or B may represent: A exists alone, A and B exist simultaneously, and B exists alone. In addition, the character " / " herein generally represents an "or" relationship between the associated objects before and after.

[0072] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A dry powder inhaler with a built-in mouthpiece dispersing unit, comprising an inhaler body with a mouthpiece, characterized in that: The mouthpiece is provided with a dispersion unit, which comprises: A first elastic grid and a second elastic grid defining an inlet and an outlet of the dispersion unit, wherein the first elastic grid and the second elastic grid allow airflow and a drug to pass through; A plurality of elastic depolymerization sheets disposed between the first elastic grid and the second elastic grid; wherein at least a portion of the elastic depolymerization sheet has a triangular cross section, and the elastic depolymerization sheet is arranged so that the edges of the triangular cross section face toward the inlet of the dispersion unit; a vibration inducing structure associated with an end anchor point of said elastic depolymerized sheet; The vibration inducing structure is configured to generate vibration in response to a portion of the inhaled airflow and transmit the vibration to the elastic depolymerization sheet through the anchor point so that the elastic depolymerization sheet vibrates during inhalation.

2. The dry powder inhaler with a built-in buccal dispersing unit according to claim 1, characterized in that: The dispersing unit further comprises: at least one purge channel; The purge channel is configured to guide a portion of the suction airflow to flow tangentially through at least one windward surface of the elastic deagglomeration sheet.

3. The dry powder inhaler with a built-in buccal dispersing unit according to claim 2, characterized in that: The purge channel has: at least one slit-like outlet; Wherein, the slit-shaped outlet is arranged adjacent to the windward surface of the elastic deagglomeration sheet.

4. The dry powder inhaler with a built-in buccal dispersing unit according to claim 3, characterized in that: The dispersing unit further comprises: at least one airflow guiding cavity disposed at an anchor point of the elastic depolymerization sheet; wherein the vibration inducing structure is associated with the airflow guiding cavity and generates vibrations in the airflow guiding cavity by receiving the portion of the inhaled airflow; Furthermore, the airflow guiding cavity has at least one outlet, and the outlet constitutes a slit-shaped outlet of the purge channel.

5. The dry powder inhaler with a built-in buccal dispersing unit according to claim 4, characterized in that: The vibration inducing structure includes an extension of the elastic depolymerized sheet itself beyond the anchor point, the extension being configured to flutter in response to a portion of the inhaled airflow.

6. The dry powder inhaler with a built-in buccal dispersing unit according to claim 5, characterized in that: The extension portion has: at least one tuning block; The tuning block is located at the end of the extension portion, and the mass of the tuning block is greater than the mass per unit length of the main body of the elastic depolymerization sheet.

7. The dry powder inhaler with a built-in buccal dispersing unit according to claim 5, characterized in that: The end of the extension portion has a serrated edge, and the thickness of the serrated edge is smaller than the thickness of the area close to the anchor point.

8. The dry powder inhaler with a built-in buccal dispersing unit according to claim 1, characterized in that: The first resilient grille defines a plurality of grille openings; Furthermore, at least a portion of the grille openings are arranged obliquely relative to the central axis of the mouthpiece; In the flow direction of the inhaled airflow, the first elastic grid is located upstream of the elastic deagglomeration sheet.

9. The dry powder inhaler with a built-in buccal dispersing unit according to claim 1, characterized in that: The inhaler body comprises: A chamber for containing a single dose of medicine; Wherein, the chamber body has a medicine outlet channel, and the medicine outlet channel is connected to the mouthpiece; Furthermore, at least one main airflow cavity is provided on the peripheral side of the medicine outlet channel, and the main airflow cavity has a main airflow port communicated with the mouthpiece.

10. The dry powder inhaler with a built-in buccal dispersing unit according to claim 9, characterized in that: The inhaler body comprises: A medicine release mechanism integrated on the inhaler body and matched with the chamber body; The drug release mechanism is used to puncture the single-dose drug.

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