Electrode device for ovarian tumor in-vivo experiment and method for determining application position

Abstract

The embodiment of the invention relates to an electrode device for an ovarian tumor in-vivo experiment and a method for determining an application position. The electrode device comprises first to fourth wiring terminals, first to fourth conductive cables, a conductive slip ring, first to fourth wires, and first and second electrode patches suitable for being attached to an animal with an ovarian tumor, wherein the conductive slip ring is configured to rotatably and electrically connect the first to fourth conductive cables with the first to fourth wires respectively; the first to fourth wiring terminals are suitable for being inserted into the electric field generator assembly, the second ends of the first to fourth conductive cables are electrically connected to the first to fourth wiring terminals respectively, the second ends of the first and third wires are electrically connected to the first electrode patch, and the second ends of the second and fourth wires are electrically connected to the second electrode patch. As a result, it is possible to perform an in vivo experiment on tumor treatment field treatment of ovarian tumors on an animal, such as a mouse, without affecting the free activity of the animal.

Description

Technical Field

[0001] Embodiments of the present disclosure generally relate to medical devices, and more particularly to an electrode device for in-vivo experiments on ovarian tumors and a method for determining the application position. Background Art

[0002] When cancer develops, cancer cells undergo rapid and uncontrolled division, and the charged proteins within the cells make the cells vulnerable to electric field interference. Tumor Treating Fields (TTFields, abbreviated as TT fields) is a brand-new tumor treatment technology, which is an alternating electric field with low intensity and medium frequency. This alternating electric field can penetrate the cancer cell membrane, interfere with the mitosis of tumor cells, thereby causing the affected cancer cells to apoptosis and inhibiting tumor growth. Moreover, by adjusting the electric field frequency, it specifically targets tumor cells without affecting most healthy cells.

[0003] Medical animal experiments are an important link in realizing scientific research from the molecular and cellular level to clinical research. Before testing on humans, it is usually necessary to first conduct relevant in-vivo experiments on animals such as mice to collect the body's response of the animals to the corresponding tumor treating fields, so as to clarify the treatment effect of the tumor treating fields and the possible negative reactions.

[0004] However, since it is difficult to restrain an animal in a fixed position without allowing it to move freely, and the animal may also affect the function of the cable due to actions such as biting, it is necessary to design a technology for conducting in-vivo experiments on animals for the treatment of ovarian tumors (also known as ovarian cancer) with tumor treating fields. Summary of the Invention

[0005] In view of the above problems, the present disclosure provides an electrode device for conducting in-vivo experiments on ovarian tumors in animals, enabling in-vivo experiments on animals such as mice for the treatment of ovarian tumors with tumor treating fields without affecting the free movement of the animals.

[0006] According to a first aspect of the present disclosure, there is provided an electrode device for performing an in-vivo experiment on ovarian tumors in animals, including first to fourth connection terminals, first to fourth conductive cables, a conductive slip ring, first to fourth wires, and first and second electrode patches adapted to be attached to an animal having ovarian tumors. The first ends of the first to fourth conductive cables are electrically connected to the first end of the conductive slip ring, and the first ends of the first to fourth wires are electrically connected to the second end of the conductive slip ring. The conductive slip ring is configured such that the first to fourth conductive cables are rotatably and electrically connected to the first to fourth wires respectively to form first to fourth signal transmission lines; the first to fourth connection terminals are adapted to be plugged into an electric field generator assembly, the second ends of the first to fourth conductive cables are electrically connected to the first to fourth connection terminals respectively, the second ends of the first and third wires are electrically connected to the first electrode patch, and the second ends of the second and fourth wires are electrically connected to the second electrode patch, so that a first alternating electric signal generated by the electric field generator assembly at a first time and a third alternating electric signal generated at a second time can be transmitted to the first electrode patch via the first signal transmission line and the third signal transmission line respectively, and a second alternating electric signal generated by the electric field generator assembly at the first time and a fourth alternating electric signal generated at the second time can be transmitted to the second electrode patch via the second signal transmission line and the fourth signal transmission line respectively. The second alternating electric signal has a polarity opposite to that of the first alternating electric signal, and the fourth alternating electric signal has a polarity opposite to that of the third alternating electric signal.

[0007] According to a second aspect of the present disclosure, there is provided a method for determining the application positions of an electrode device on an animal, where the electrode device is the electrode device according to the first aspect of the present disclosure. The method includes: obtaining a three-dimensional simulation model of the trunk part of the animal, where the trunk part includes the ovarian tumor; constructing corresponding first simulation electrode patches and second simulation electrode patches for the first electrode patch and the second electrode patch respectively, and setting a first simulation alternating signal and a second simulation alternating signal for the first simulation electrode patch and the second simulation electrode patch respectively, where the first simulation alternating signal and the second simulation alternating signal have opposite polarities; based on the three-dimensional simulation model, determining a plurality of first candidate application positions for applying the first simulation electrode patch on the three-dimensional simulation model and a plurality of second candidate application positions for applying the second simulation electrode patch on the three-dimensional simulation model; for each combination of one of the plurality of first candidate application positions and one of the plurality of second candidate application positions, determining the intensity of the alternating electric field formed between the first simulation alternating signal and the second simulation alternating signal when the first simulation electrode patch is set at the corresponding first candidate application position and the second simulation electrode patch is set at the corresponding second candidate application position; and determining the first candidate application position and the second candidate application position corresponding to the alternating electric field with the maximum intensity as the final application positions, so as to determine the positions on the animal for applying the first electrode patch and the second electrode patch respectively based on the final application positions and the three-dimensional simulation model.

[0008] It should be understood that the content described in this part is not intended to identify the key or important features of the embodiments of the present disclosure, nor is it used to limit the scope of the present disclosure. Other features of the present disclosure will become easily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] In combination with the accompanying drawings and with reference to the following detailed description, the above and other features, advantages, and aspects of the embodiments of the present disclosure will become more apparent. In the drawings, the same or similar reference numerals denote the same or similar elements.

[0010] Figure 1 The structural schematic diagram of an exemplary electrode device 100 according to an embodiment of the present disclosure is shown.

[0011] Figure 2 The exploded view of an electrode patch 200 according to an embodiment of the present disclosure is shown.

[0012] Figure 3A The exploded view of a transducer assembly 300 according to an embodiment of the present disclosure is shown.

[0013] Figure 3B The embodiment according to the present disclosure is shown Figure 3ASchematic diagram of the flexible circuit board 320 in the transducer assembly 300 shown.

[0014] Figure 4 Shows an electric field generator assembly 400 for providing an alternating electric signal to the Figure 1 electrode device 100 shown according to an embodiment of the present disclosure.

[0015] Figure 5 Shows an illustrative schematic diagram of a mouse wearing the Figure 1 electrode device 100 shown according to an embodiment of the present disclosure.

[0016] Figure 6 Shows a flowchart of a method 600 for determining the application position of an electrode device on an animal according to an embodiment of the present disclosure.

[0017] Figure 7 Shows a block diagram of an electronic device 700 according to an embodiment of the present disclosure. Detailed Description of the Invention

[0018] The exemplary embodiments of the present disclosure will be described below with reference to the accompanying drawings. Various details of the embodiments of the present disclosure are included to assist in understanding, and they should be considered merely exemplary. Therefore, those of ordinary skill in the art should recognize that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of the present disclosure. Similarly, for the sake of clarity and conciseness, descriptions of well-known functions and structures are omitted below.

[0019] As used herein, the term "comprising" and its variants mean open inclusion, i.e., "including but not limited to". Unless otherwise stated, the term "or" means "and / or". The term "based on" means "at least partially based on". The terms "an example embodiment" and "an embodiment" mean "at least one example embodiment". The term "another embodiment" means "at least one additional embodiment". The terms "first", "second", etc. may refer to different or the same objects. There may be other explicit and implicit definitions hereinafter.

[0020] As described above, medical animal experiments are an important link in realizing scientific research from the molecular and cellular levels to clinical research. Before testing on humans, it is usually necessary to first conduct relevant in-vivo experiments on animals such as mice to collect the body's response of the animals to the corresponding tumor treatment field, so as to clarify the treatment effect of the tumor treatment field and the possible negative reactions. However, since it is difficult to restrain the animal in a fixed position without allowing it to move freely, and the animal may also affect the function of the cable due to actions such as gnawing, it is necessary to design a technique for conducting in-vivo experiments on animals for the treatment of the tumor treatment field of ovarian tumors.

[0021] To at least partially solve one or more of the above problems and other potential problems, exemplary embodiments of the present disclosure provide an electrode device for performing in-vivo experiments on ovarian tumors in animals, including first to fourth connection terminals, first to fourth conductive cables, a conductive slip ring, first to fourth wires, and first and second electrode patches adapted to be attached to an animal with an ovarian tumor.

[0022] The first ends of the first to fourth conductive cables are electrically connected to the first end of the conductive slip ring, and the first ends of the first to fourth wires are electrically connected to the second end of the conductive slip ring. The conductive slip ring is configured such that the first to fourth conductive cables are rotatably and electrically connected to the first to fourth wires respectively, to form first to fourth signal transmission lines.

[0023] The first to fourth connection terminals are adapted to be plugged into an electric field generator assembly. The second ends of the first to fourth conductive cables are electrically connected to the first to fourth connection terminals respectively. The second ends of the first and third wires are electrically connected to the first electrode patch, and the second ends of the second and fourth wires are electrically connected to the second electrode patch, such that a first alternating electric signal generated by the electric field generator assembly at a first time and a third alternating electric signal generated at a second time can be transmitted to the first electrode patch via the first signal transmission line and the third signal transmission line respectively, and a second alternating electric signal generated by the electric field generator assembly at the first time and a fourth alternating electric signal generated at the second time can be transmitted to the second electrode patch via the second signal transmission line and the fourth signal transmission line respectively. The second alternating electric signal has a polarity opposite to that of the first alternating electric signal, and the fourth alternating electric signal has a polarity opposite to that of the third alternating electric signal. In this way, in-vivo experiments on tumor treatment fields for ovarian tumors can be performed on animals such as mice with ovarian tumors without affecting the free movement of the animals.

[0024] Figure 1 FIG. shows a schematic structural diagram of an exemplary electrode device 100 according to an embodiment of the present disclosure. As Figure 1As shown in the figure, the electrode device 100 includes first to fourth connection terminals 110-1 to 110-4 (hereinafter collectively referred to as connection terminals 110), first to fourth conductive cables 120-1 to 120-4 (hereinafter collectively referred to as conductive cables 120), a conductive slip ring 130, first to fourth wires 140-1 to 140-4 (hereinafter collectively referred to as wires 140), and first and second electrode patches 150-1, 150-2 (hereinafter collectively referred to as electrode patches 150) adapted to be applied to an animal with an ovarian tumor. In the present disclosure, in order to form an alternating electric field for treating ovarian tumors, the electrode device 100 should include two electrode patches 150, which are adapted to be disposed at two different positions on the animal under experiment so as to generate corresponding alternating electric fields when receiving alternating electric signals with opposite polarities respectively.

[0025] In the present disclosure, the first ends of the first to fourth conductive cables 120 are all electrically connected to the first end of the conductive slip ring 130, and the first ends of the first to fourth wires 140 are all electrically connected to the second end of the conductive slip ring 130. The conductive slip ring 130 is configured such that the first to fourth conductive cables 120 are respectively rotatably electrically connected to the first to fourth wires 140 to respectively form first to fourth signal transmission lines. Specifically, the first conductive cable 120-1 and the first wire 140-1 form the first signal transmission line through the rotatable connection of the conductive slip ring 130; the second conductive cable 120-2 and the second wire 140-2 form the second signal transmission line through the rotatable connection of the conductive slip ring 130; the third conductive cable 120-3 and the third wire 140-3 form the third signal transmission line through the rotatable connection of the conductive slip ring 130; and the fourth conductive cable 120-4 and the fourth wire 140-4 form the fourth signal transmission line through the rotatable connection of the conductive slip ring 130. Since the conductive slip ring 130 can achieve the rotatable connection between the corresponding conductive cable 140 and the corresponding wire 140, after the corresponding animal (especially a mouse) wears the electrode device 100, it can still move around freely without being pulled by the wires, and it will not affect the normal operation of the electrode device 100.

[0026] In addition, in Figure 1In the illustrated embodiment, the total length of the first conductive cable 120-1 and the first wire 140-1 should be selected such that the corresponding first transmission line does not interfere with the free movement of the animal within a predetermined range. Thus, the animal can further move freely within the predetermined range without being pulled by the wire 140 and without affecting the normal operation of the electrode device 100. Additionally, such requirements also apply to the total lengths of the second conductive cable 120-2 and the second wire 140-2, the total lengths of the third conductive cable 120-3 and the third wire 140-3, and the total lengths of the fourth conductive cable 120-4 and the fourth wire 140-4. Generally, the first to fourth conductive cables 120-1, 120-2, 120-3, 120-4 mentioned above can all be selected to have the same length, and the first to fourth wires 140-1, 140-2, 140-3, 140-4 can also all be selected to have the same length.

[0027] Continuing as in Figure 1 the illustrated embodiment, the first to fourth terminal blocks 110 are adapted to be plugged into an electric field generator assembly (e.g., as Figure 4on the electric field generator assembly 400 shown. Additionally, the second ends of the first to fourth conductive cables 120 are electrically connected to the first to fourth connection terminals 110 respectively, and the second ends of the first wire 140-1 and the third wire 140-3 are electrically connected (e.g., welded) to the first electrode patch 150-1, and the second ends of the second wire 140-2 and the fourth wire 140-4 are electrically connected to the second electrode patch 150-2. Through the above connection method, the first alternating current signal generated by the electric field generator assembly 400 at the first time can be transmitted to the first electrode patch 150-1 via the first signal transmission line formed by electrically connecting the first conductive cable 120-1 and the first wire 140-1, and the second alternating current signal generated by the electric field generator assembly 400 at the first time can be transmitted to the second electrode patch 150-2 via the second signal transmission line formed by electrically connecting the second conductive cable 120-2 and the second wire 140-2, where the second alternating current signal has the opposite polarity to the first alternating current signal so as to be able to form a corresponding first alternating electric field. Additionally, the third alternating current signal generated by the electric field generator assembly 400 at the second time can be transmitted to the first electrode patch 150-1 via the third signal transmission line formed by electrically connecting the third conductive cable 120-3 and the third wire 140-3, and the fourth alternating current signal generated by the electric field generator assembly 400 at the second time can be transmitted to the second electrode patch 150-2 via the fourth signal transmission line formed by electrically connecting the fourth conductive cable 120-4 and the fourth wire 140-4, where the third alternating current signal also has the opposite polarity to the fourth alternating current signal so as to be able to form a corresponding second alternating electric field. In the present disclosure, the aforementioned first time and second time occur alternately, and both the first time and the second time are periodic.

[0028] When performing in-vivo experiments on animals (such as mice) with ovarian tumors, the first electrode patch 150-1 is adapted to be applied to the first position (e.g., the position 501 as shown) on the animal associated with its ovarian tumor, and the second electrode patch 150-2 is adapted to be applied to the second position (e.g., the position 502 as shown) on the animal associated with its ovarian tumor to form a first alternating electric field between the first alternating current signal and the second alternating current signal (i.e., between the first position and the second position) when the first electrode patch 150-2 and the second electrode patch 150-2 receive the first alternating current signal and the second alternating current signal respectively. Additionally, in the embodiment shown, a second alternating electric field can also be formed between the third alternating current signal and the fourth alternating current signal (i.e., between the first position and the second position) when the first electrode patch 150-1 and the second electrode patch 150-2 receive the third alternating current signal and the fourth alternating current signal respectively. For Figure 5 shown, the second electrode patch 150-2 is adapted to be applied to the second position (e.g., the position 502 as shown) on the animal associated with its ovarian tumor to form a first alternating electric field between the first alternating current signal and the second alternating current signal (i.e., between the first position and the second position) when the first electrode patch 150-2 and the second electrode patch 150-2 receive the first alternating current signal and the second alternating current signal respectively. Additionally, in the Figure 5 embodiment shown, a second alternating electric field can also be formed between the third alternating current signal and the fourth alternating current signal (i.e., between the first position and the second position) when the first electrode patch 150-1 and the second electrode patch 150-2 receive the third alternating current signal and the fourth alternating current signal respectively. Figure 1 the embodiment shown, a second alternating electric field can also be formed between the third alternating current signal and the fourth alternating current signal (i.e., between the first position and the second position) when the first electrode patch 150-1 and the second electrode patch 150-2 receive the third alternating current signal and the fourth alternating current signal respectively. Figure 1In the illustrated embodiment, the first position and the second position should be selected such that the first alternating electric field can pass through (i.e., act on) the ovarian tumor, and the second alternating electric field can also pass through (i.e., act on) the ovarian tumor, so that the first alternating electric field and the second alternating electric field can play a role in treating the ovarian tumor.

[0029] To achieve a better treatment effect, the first alternating electric field and the second alternating electric field formed are preferably perpendicular to each other. For example, as Figure 1 shown, the first electrode patch 150-1 may include a first transducer assembly 1501 and a second transducer assembly 1502, and the second electrode patch 150-2 may include a third transducer assembly 1503 and a fourth transducer assembly 1504. In the present disclosure, the transducer assemblies 1501-1504 in the first electrode patch 150-1 and the second electrode patch 150-2 are all used to receive corresponding alternating electric signals for generating corresponding alternating electric fields. The first electrode patch 150-1 is arranged such that the first transducer assembly 1501 is closer to the conductive slip ring 130 than the second transducer assembly 1502, and the second electrode patch 150-2 is arranged such that the third transducer assembly 1502 is closer to the conductive slip ring 130 than the fourth transducer assembly 1504. The first electrode patch 150-1 is electrically connected to the first wire 140-1 via the first transducer assembly 1501 to receive the first alternating electric signal, and is electrically connected to the third wire 140-3 via the second transducer assembly 1502 to receive the third alternating electric signal. The second electrode patch 150-2 is electrically connected to the fourth wire 140-4 via the third transducer assembly 1503 to receive the fourth alternating electric signal, and is electrically connected to the second wire 140-2 via the fourth transducer assembly 1504 to receive the second alternating electric signal.

[0030] In addition, for the convenience of wiring, the first transducer assembly 1501 is electrically connected to the first wire 140-1 at the first end of its side facing the conductive slip ring 130 (the long side in Figure 1 ), the second transducer assembly 1502 is electrically connected to the third wire 140-3 at the second end of its side facing the conductive slip ring 130 (the long side in Figure 1 ), the third transducer assembly 1503 is electrically connected to the fourth wire 140-4 at the first end of its side facing the conductive slip ring 130 (the long side in Figure 1 ), and the fourth transducer assembly 1504 is electrically connected to the second wire 140-2 at the second end of its side facing the conductive slip ring 130 (the long side in Figure 1 ).

[0031] The specific structures of the electrode patch 150 and the transducer assemblies 1501-1504 will be described below in combination with Figure 2 and Figures 3A - 3BA further more detailed description will be given.

[0032] In some embodiments, the electrode device 100 may further include medical tapes (e.g., medical tapes 160-1 and 160-2 as Figure 1 shown). The medical tapes 160-1 and 160-2 are configured to fix the wires 140 connected to the corresponding electrode patches 150 on the flexible support layer 170 of the electrode patch 150. For example, in the Figure 1 illustrated embodiment, there are two medical tapes. The first medical tape 160-1 is used to commonly fix the first wire 140-1 and the third wire 140-3 on the flexible support layer 170 of the first electrode patch 150-1 (e.g., fixed on the short side of the flexible support layer), and the second medical tape 160-2 is used to fix the second wire 140-2 and the fourth wire 140-4 on the flexible support layer 170 of the second electrode patch 150-2 (e.g., fixed on the short side of the flexible support layer). In the present disclosure, by using medical tapes, it can prevent the wires from being chewed by animals during movement, thus affecting the treatment effect.

[0033] Figure 2 An exploded view of the electrode patch 200 according to an embodiment of the present disclosure is shown. As Figure 2 shown, the electrode patch 200 can be Figure 1 the first electrode patch 150-1 in Figure 1 or the second electrode patch 150-2 in

[0034] As Figure 2 shown, the electrode patch 200 includes first and second adhesive members 210-1, 210-2 (hereinafter collectively referred to as the adhesive member 210), a support body 220, first and second transducer assemblies 230-1, 230-2 (hereinafter collectively referred to as the transducer assembly 230) (e.g., the first transducer assembly 1501 and the second transducer assembly 1502 of the first electrode patch and the third transducer assembly 1503 and the third transducer assembly 1504 of the second electrode patch mentioned above), and a flexible support layer 240.

[0035] The support body 220 includes a first through hole 220-1 adapted to the shape of the first transducer assembly 230-1 and a second through hole 220-2 adapted to the shape of the second transducer assembly 230-2, and both the first through hole 220-1 and the second through hole 220-2 are through in the middle. The first transducer assembly 230-1 is fixedly mounted in the first through hole 220-1 in an embedded manner, and the second transducer assembly 230-2 is fixedly mounted in the second through hole 220-2 in an embedded manner, so as to firmly fix the first transducer assembly 230-1 and the second transducer assembly 230-2. In some embodiments, the support body 220 can be made of a foam material, so that when the electrode patch 200 is applied to an animal, the electrode patch can be prevented from squeezing the mouse, causing discomfort to the mouse, and the pressure on the mouse can be reduced.

[0036] In the present disclosure, both the first adhesive member 210-1 and the second adhesive member 210-2 can have double-sided adhesiveness. Specifically, the first surface of the first adhesive member 210-1 is adhered to the first surface of the first transducer assembly 230-1 in a manner covering the first through hole 220-1, and the second surface of the first adhesive member 210-1 is adapted to be used as an application layer to be applied to an animal (mainly applied to the skin of the animal). Similarly, the first surface of the second adhesive member 210-2 is adhered to the first surface of the second transducer assembly 230-2 in a manner covering the second through hole 220-2, and the second surface of the second adhesive member 210-2 is also adapted to be used as an application layer to be applied to an animal (mainly applied to the skin of the animal). In the present disclosure, the first surface of the first transducer assembly 230-1 embedded in the first through hole 220-1 of the support body 220 and the first surface of the second transducer assembly 230-2 embedded in the second through hole 220-2 of the support body 220 should be flush with the surface of the support body 220 on the side away from the flexible support layer 240, so that both the first adhesive member 210-1 and the second adhesive member 210-2 can be firmly adhered to the first transducer assembly 230-1, the second transducer assembly 230-2, and the support body 220. The first and second adhesive members 210 are required to keep the skin surface moist when applied to the skin of an animal, so as to relieve the local pressure on the skin. In some embodiments, the first adhesive member 210-1 and the second adhesive member 210-2 can be made of a conductive hydrogel to act as a conductive medium.

[0037] The flexible support layer 240 is attached to the surface of the support body 220 away from the adhesive member 210, as well as the second surfaces of the first transducer assembly 230-1 and the second transducer assembly 230-2. For example, the flexible support layer 240 may include a biocompatible adhesive, and it can be adhered to the support body 220 and the first and second transducer assemblies 230-1, 230-2 through this biocompatible adhesive. In some embodiments, the flexible support layer 240 is made of non-woven fabric. The flexible support layer 240 can play a role in fixing the transducer assembly 230.

[0038] Figure 3A An exploded view of a transducer assembly 300 according to an embodiment of the present disclosure is shown, and Figure 3B An embodiment according to the present disclosure is shown Figure 3A A schematic diagram of the flexible printed circuit board 320 in the transducer assembly 300 shown. As Figure 3A and 3B The transducer assembly 300 shown can be Figure 2 the first transducer assembly 230-1 in Figure 2 or the second transducer assembly 230-2 in

[0039] As Figure 3A and 3B shown, the transducer assembly 300 includes: a reinforcing plate 330, a flexible printed circuit board 320, and a ceramic sheet 310. In the present disclosure, the flexible printed circuit board 320 is disposed on the reinforcing plate 320, and the size of the reinforcing plate 320 can be substantially the same as the size of the flexible printed circuit board 320 to provide strength support for the flexible printed circuit board 320. The reinforcing plate 320 can be made of, for example, epoxy laminated glass cloth (i.e., FR-4 insulating board).

[0040] The flexible printed circuit board 320 may include a main body portion 3201 and a protruding portion 3202, and the protruding portion 3202 can be formed at the edge of the main body portion 3201. A first conductive pad 3203 is disposed on the main body portion 3201, and a second conductive pad 3204 is disposed on the protruding portion 3202. The first conductive pad 3203 can be disposed in the middle of the main body portion 3201, and the second conductive pad 3204 can be disposed in the middle of the protruding portion 3202. In the present disclosure, the first conductive pad 3203 and the second conductive pad 3204 are electrically connected to each other. The ceramic sheet 310 can be welded to the flexible printed circuit board 320 through the first conductive pad 3203, and the corresponding wire 140 (for example, one of the first to fourth wires mentioned above) can be welded to the flexible printed circuit board 320 through the second conductive pad 3204, thereby realizing the electrical connection between the wire 140 and the electrode pads 150, 200 where the transducer assembly 300 is located.

[0041] In some embodiments, for the first transducer assembly 230-1 and the second transducer assembly 230-2 disposed on the same electrode patch (which can be the aforementioned first electrode patch 150-1 or the second electrode patch 150-2), the protruding portions of the first flexible circuit board of the first transducer assembly 230-1 and the protruding portions of the second flexible circuit board of the second transducer assembly 230-2 can be respectively disposed on the same-side edges of the two corresponding flexible circuit boards facing the same direction (for example, on the long sides of the two flexible circuit boards facing the conductive slip ring 130), but are respectively disposed at the two opposite ends of these two long sides. For example, the protruding portion of the first flexible circuit board can be disposed at the first end (for example, the left end) of the side of the first flexible circuit board facing the conductive slip ring 130, and the protruding portion of the second flexible circuit board can be disposed at the second end (for example, the right end) of the side of the second flexible circuit board facing the conductive slip ring 130. For example, taking the first electrode patch 150-1 as an example, the protruding portion of the first flexible circuit board of the first transducer assembly 1501 of the first electrode patch 150-1 is disposed at the first end (for example, the left end) of the side of the first flexible circuit board facing the conductive slip ring (the long side in Figure 1 and 2 ), so that the first transducer assembly 1501 can electrically connect to the first wire 140-1 at the first end of the side of it facing the conductive slip ring 130, while the protruding portion of the second flexible circuit board of the second transducer assembly 1502 of the first electrode patch 150-1 is disposed at the second end (for example, the right end) of the side of the second flexible circuit board facing the conductive slip ring 130 (the long side in Figure 1 and 2 ), so that the second transducer assembly 1502 can electrically connect to the third wire 140-3 at the second end of the side of it facing the conductive slip ring 130. Therefore, when the first electrode patch 150-1 is assembled, it is beneficial for the wiring arrangement of the first wire 140-1 and the third wire 140-3, and can avoid the wiring bending of the first wire and the third wire in the first electrode patch 150-1, and can avoid causing the fracture of the soldering joint of the first wire 140-1 on the second conductive pad of the first flexible circuit board, and can also avoid causing the fracture of the soldering joint of the third wire 140-3 on the second conductive pad of the second flexible circuit board. In addition, the second electrode patch 150-2 has a similar arrangement and function.

[0042] In the present disclosure, the dimensional strain of each part of the electrode patch 150 (e.g., the first electrode patches 150-1 and 150-2) is designed such that the electrode patch 150 can be stably attached to the animal receiving the experiment, and the first alternating electric field and the second alternating electric field generated by the two electrode patches 150 can act well on the ovarian tumor of the animal without causing unnecessary electric field loss. For example, by way of example only, in the example where the electrode device 100 of the present disclosure is applied to a mouse with an ovarian tumor, the size of the protruding portion 3202 of the flexible circuit board 320 in each transducer assembly 230 of the electrode patch can be, for example, 13 mm × 7 mm, and the size of the ceramic sheet 310 can be, for example, 11 mm × 5 mm. The two transducer assemblies 230 on each electrode patch 150 can be aligned in such a way that the long sides of the first flexible circuit board and the second flexible circuit board are adjacent. The spacing between the two transducer assemblies 230 on the same electrode patch 150 (e.g., the spacing between the first transducer assembly 1501 and the second transducer assembly 1502 or the spacing between the third transducer assembly 1503 and the fourth transducer assembly 1504) can be less than or equal to, for example, 10 mm. Since alternating electric fields perpendicular to each other need to be formed on both sides and the mouse has a small body size, taking a maximum spacing distance of 10 mm can ensure that the first alternating electric field and the second alternating electric field are as perpendicular as possible to reduce electric field loss. In the present disclosure, the spacing between the two transducer assemblies 300 can refer to the spacing between the two flexible circuit boards 320 or the ceramic sheets 310 of the two transducer assemblies 300. The size of the electrode patch 150 can be, for example, 32 mm × 23 mm. In the present disclosure, the size of the flexible support layer 240 of the electrode patch 200 can be regarded as the size of the electrode patch 150. The short side of the flexible circuit board 320 in each transducer assembly 230 in the electrode patch 150 can be arranged parallel to the long side of the flexible support layer 240 in the electrode patch 150. The short side of the flexible circuit board 320 can be, for example, about 1.5 mm away from the long side of the flexible support layer 240. The size of the support body 220 of the electrode patch 150 can be, for example, 26 mm × 20 mm, and the first through hole 220-1 and the second through hole 220-2 formed on the support body can be, for example, about 10 mm apart, so as to ensure that the spacing between the two transducer assemblies 300 on the electrode patch 150 is about 10 mm, which is conducive to the formation of mutually perpendicular alternating electric fields after the ceramic sheets 310 on the transducer assemblies 230 and 300 are passed through by alternating current signals. The size of each adhesive 210 in the electrode patch 150 can be slightly larger than the size of the ceramic sheet 310 and slightly smaller than the size of the flexible circuit board 320. In this embodiment, the size of the adhesive 210 can be, for example, 12 mm × 7 mm.

[0043] Figure 4 Shows a schematic diagram of a device for Figure 1The structural block diagram of the electric field generator assembly 400 of the electrode device 100 shown provides an alternating electric signal. As Figure 4 shown, the electric field generator assembly 400 may include an electric field generator 410, an adapter 420, and an adapter board 430.

[0044] The electric field generator 410 is configured to generate a pair of alternating electric signals with opposite polarities (i.e., the first alternating electric signal and the second alternating electric signal mentioned above) at a first time, and generate another pair of alternating electric signals with opposite polarities (i.e., the third alternating electric signal and the fourth alternating electric signal mentioned above) at a second time. The first time when the electric field generator 410 generates the first and second alternating electric signals and the second time when it generates the third and fourth alternating electric signals are switched with each other, so that the first and second alternating electric signals and the third and fourth alternating electric signals are generated alternately.

[0045] The adapter 420 is electrically connected to the electric field generator 410 and is configured to divide the four alternating electric signals generated by the electric field generator 410 into four signal lines (i.e., Figure 4 the signal lines X1, X2, Y1, and Y2 shown), where, for example, the signal line X1 is used to output the first alternating electric signal, the signal line Y1 is used to output the second alternating electric signal, the signal line X2 is used to output the third alternating electric signal, and the signal line Y2 is used to output the fourth alternating electric signal.

[0046] The adapter board 430 is configured to parallelly divide the output of each signal line of the adapter 420 into multiple outputs of corresponding alternating electric signals, so that the in-vivo experimental tumor electric field treatment system can simultaneously perform in-vivo experiments on multiple animals with ovarian tumors. In this embodiment, the adapter board 430 includes a first adapter board 4301 and a second adapter board 4302. The first adapter board 4301 and the second adapter board 4302 can be stacked to increase the number of animals that can simultaneously receive ovarian tumor experience experiments, while reducing the area occupied by the adapter board 430 and facilitating the flexible placement of the adapter board 430. A plurality of connection sockets are provided on both sides of the first adapter board 4301 and the second adapter board 4302. The four signal line outputs of the adapter 420 are electrically connected to the same side of the first adapter board 4301 and the second adapter board 4302 respectively. For example, the first adapter board 4301 is electrically connected to the signal lines X1 and X2 of the adapter 420 respectively used to output the first alternating electric signal and the third alternating electric signal, and the second adapter board 4302 is electrically connected to the signal lines Y1 and Y2 of the adapter 420 respectively used to output the second alternating electric signal and the fourth alternating electric signal. Sockets for inserting the corresponding connection terminals of a plurality of electrode devices 100 are respectively provided on the sides of the first adapter board 4301 and the second adapter board 4302 away from the adapter 420. For example, as Figure 4As shown, on one side of the first adapter board 4301 away from the adapter 420, there are provided 5 signal output sockets 1X1, 2X1, 3X1, 4X1, 5X1 for outputting the first alternating current signal and 5 signal output sockets 1X2, 2X2, 3X2, 4X2, 5X2 for outputting the third alternating current signal. On one side of the second adapter board 4302 away from the adapter 420, there are provided 5 signal output sockets 1Y1, 2Y1, 3Y1, 4Y1, 5Y1 for outputting the second alternating current signal and 5 signal output sockets 1Y2, 2Y2, 3Y2, 4Y2, 5Y2 for outputting the fourth alternating current signal. 4 wiring terminals 110 of the electrode device 100 can be respectively inserted into the above signal output sockets 1X1, 1X2, 1Y1 and 1Y2. Additional electrode devices (if any) can be respectively inserted into the above signal output sockets 2X1, 2X2, 2Y1 and 2Y2, and so on. Thus, through the electric field generator assembly 400 as shown in Figure 4 simultaneous in-vivo experiments on 5 animals for ovarian tumors can be achieved. Of course, it should be understood that Figure 4 is merely exemplary. The adapter board 430 may further include more adapter boards, and each adapter board may further include more or fewer signal output sockets.

[0047] Figure 6 The flowchart of a method 600 for determining the application position of an electrode device on an animal according to an embodiment of the present disclosure is shown.

[0048] In step 602, a three-dimensional simulation model of the trunk part of the animal (i.e., an animal such as a mouse that needs to receive this in-vivo experiment) is obtained, and the trunk part includes an ovarian tumor.

[0049] In some embodiments, the three-dimensional simulation model in step 602 can be constructed in the following manner. First, tomographic scan images of the trunk part of the animal (e.g., computed tomography images (i.e., CT images), multi-functional optical tomography images (i.e., OCT images), etc.) are obtained, and then the three-dimensional simulation model can be generated based on these tomographic scan images. Generating a three-dimensional simulation model based on tomographic scan images can be achieved using methods known in the art and will not be elaborated here.

[0050] In step 604, corresponding first and second simulated electrode patches are respectively constructed for the first and second electrode patches (e.g., Figure 1 the first electrode patch 150-1 and the second electrode patch 150-2 as shown), and a first simulated alternating current signal and a second simulated alternating current signal are respectively set for the first and second simulated electrode patches, and the first simulated alternating current signal and the second simulated alternating current signal have opposite polarities.

[0051] For example, simulation software such as COMSOL Multiphysics can be used to construct each simulation electrode patch and set the simulated alternating electric signals applied thereto.

[0052] In the present disclosure, the size ratio relationship between the above three-dimensional simulation model and the trunk of the animal is the same as the size ratio relationship between the first and second electrode patches and the first and second simulation electrode patches respectively, so as to facilitate subsequent conversion.

[0053] In step 606, based on the three-dimensional simulation model obtained in step 602, a plurality of candidate patch position combinations for applying the first simulation electrode patch and the second simulation electrode patch on the three-dimensional simulation model are determined. Each candidate patch position combination includes a first candidate patch position for applying the first simulation electrode patch and a second candidate patch position for applying the second simulation electrode patch.

[0054] In some embodiments, for example, a plurality of candidate patch position combinations can be determined respectively based on the position and size of the ovarian tumor in the three-dimensional simulation model and the sizes of the first simulation electrode patch and the second simulation electrode patch.

[0055] In the present disclosure, the first simulation electrode patch and the second simulation electrode patch can be the same simulation electrode patch.

[0056] In some embodiments, the distance between each first candidate patch position and the second candidate patch position can be determined first according to the size of the ovarian tumor in the three-dimensional simulation model and the sizes of the respective simulation electrode patches. Then, according to the position of the ovarian tumor in the three-dimensional simulation model, considering the sizes of the first and second simulation electrode patches, a plurality of candidate patch position combinations are determined based on the distance.

[0057] In step 608, for each candidate patch position combination, when the first simulation electrode patch is set at the corresponding first candidate patch position and the second simulation electrode patch is set at the corresponding second candidate patch position, the intensity of the alternating electric field formed between the first simulation alternating signal and the second simulation alternating signal is determined.

[0058] In step 610, the first candidate patch position and the second candidate patch position in the candidate patch position combination corresponding to the determined maximum intensity are determined as the final patch positions, so as to determine the positions on the animal for applying the first electrode patch and the second electrode patch respectively based on the final patch positions and the three-dimensional simulation model.

[0059] Since the size ratio relationship between the above three-dimensional simulation model and the trunk of the animal is the same as the size ratio relationship between the first and second electrode patches and the first and second simulation electrode patches respectively, the positions on the animal for applying the first and second electrode patches can be determined based on the conversion using this ratio relationship, the final application position, and the three-dimensional simulation model.

[0060] Figure 7 FIG. shows a schematic block diagram of an exemplary electronic device 700 that can be used to implement embodiments of the present disclosure. For example, the computing device for implementing method 600 can be implemented by electronic device 700. As shown, electronic device 700 includes a central processing unit (CPU) 701, which can perform various appropriate actions and processes according to computer program instructions stored in read-only memory (ROM) 702 or computer program instructions loaded from storage unit 708 into random access memory (RAM) 703. In random access memory 703, various programs and data required for the operation of electronic device 700 can also be stored. The central processing unit 701, read-only memory 702, and random access memory 703 are connected to each other via a bus 704. An input / output (I / O) interface 705 is also connected to bus 704.

[0061] Multiple components in electronic device 700 are connected to input / output interface 705, including: an input unit 706, such as a keyboard, mouse, microphone, etc.; an output unit 707, such as various types of displays, speakers, etc.; a storage unit 708, such as a magnetic disk, optical disk, etc.; and a communication unit 709, such as a network card, modem, wireless communication transceiver, etc. Communication unit 709 allows device 700 to exchange information / data with other devices via a computer network such as the Internet and / or various telecommunication networks.

[0062] The various processes and treatments described above, such as method 600, can be executed by central processing unit 701. For example, in some embodiments, method 600 can be implemented as a computer software program tangibly embodied in a machine-readable medium, such as storage unit 708. In some embodiments, part or all of the computer program can be loaded and / or installed onto device 700 via read-only memory 702 and / or communication unit 709. When the computer program is loaded into random access memory 703 and executed by central processing unit 701, one or more actions of method 600 described above can be performed.

[0063] The present disclosure relates to methods, devices, systems, electronic devices, computer-readable storage media, and / or computer program products. The computer program product may include computer-readable program instructions for performing various aspects of the present disclosure.

[0064] A computer-readable storage medium can be a tangible device that can retain and store instructions for use by an instruction execution device. A computer-readable storage medium may be, for example—but not limited to—an electrical storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. More specific examples (a non-exhaustive list) of the computer-readable storage medium include: a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), a static random access memory (SRAM), a portable compact disc read-only memory (CD-ROM), a digital versatile disc (DVD), a memory stick, a floppy disk, a mechanically encoded device such as a punched card or raised structures in grooves having instructions stored thereon, and any suitable combination of the foregoing. The computer-readable storage medium as used herein is not construed as being a transient signal per se, such as a radio wave or other freely propagating electromagnetic wave, an electromagnetic wave propagating through a waveguide or other transmission medium (e.g., an optical pulse through an optical fiber cable), or an electrical signal transmitted through a wire.

[0065] The computer-readable program instructions described herein can be downloaded from a computer-readable storage medium to respective computing / processing devices, or downloaded to an external computer or external storage device via a network, such as the Internet, a local area network, a wide area network, and / or a wireless network. The network may include a copper transmission cable, an optical fiber transmission, a wireless transmission, a router, a firewall, a switch, a gateway computer, and / or an edge computing device. A network adapter card or network interface in each computing / processing device receives the computer-readable program instructions from the network and forwards the computer-readable program instructions for storage in a computer-readable storage medium in each computing / processing device.

[0066] The computer program instructions for performing the operations of the present disclosure may be assembly instructions, instruction set architecture (ISA) instructions, machine instructions, machine - related instructions, microcode, firmware instructions, state - setting data, or source code or object code written in any combination of one or more programming languages, including object - oriented programming languages such as Smalltalk, C++, etc., and conventional procedural programming languages such as the "C" language or similar programming languages. The computer - readable program instructions may be executed entirely on the user's computer, partially on the user's computer, executed as a stand - alone software package, partially on the user's computer and partially on a remote computer, or entirely on a remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer through any type of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computer (e.g., through the Internet using an Internet service provider). In some embodiments, by using the state information of the computer - readable program instructions to customize an electronic circuit, such as a programmable logic circuit, a field - programmable gate array (FPGA), or a programmable logic array (PLA), the electronic circuit can execute the computer - readable program instructions to implement various aspects of the present disclosure.

[0067] Aspects of the present disclosure are described herein with reference to the flowcharts and / or block diagrams of methods, apparatus (systems), and computer program products according to embodiments of the present disclosure. It should be understood that each block of the flowcharts and / or block diagrams, and combinations of blocks in the flowcharts and / or block diagrams, can be implemented by computer - readable program instructions.

[0068] These computer - readable program instructions can be provided to a processing unit of a general - purpose computer, a special - purpose computer, or other programmable data - processing apparatus to produce a machine such that, when the instructions are executed by the processing unit of the computer or other programmable data - processing apparatus, a device is created that implements the functions / acts specified in one or more blocks of the flowchart and / or block diagram. These computer - readable program instructions can also be stored in a computer - readable storage medium, which causes a computer, a programmable data - processing apparatus, and / or other devices to operate in a particular manner. Thus, the computer - readable medium storing the instructions includes a manufacture that includes instructions for implementing various aspects of the functions / acts specified in one or more blocks of the flowchart and / or block diagram.

[0069] Computer-readable program instructions may also be loaded onto a computer, other programmable data processing apparatus, or other devices, causing a series of operational steps to be performed on the computer, other programmable data processing apparatus, or other devices to generate a computer-implemented process such that the instructions executed on the computer, other programmable data processing apparatus, or other devices implement the functions / acts specified in one or more boxes of the flowchart and / or block diagram.

[0070] The flowcharts and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods, and computer program products according to various embodiments of the present disclosure. In this regard, each block in the flowchart or block diagram may represent a module, a segment of code, or a portion of an instruction, which contains one or more executable instructions for implementing the specified logical function. In some alternative implementations, the functions noted in the blocks may occur out of the order noted in the figures. For example, two consecutive blocks may in fact be executed substantially in parallel, or they may sometimes be executed in the reverse order, depending upon the functionality involved. It should also be noted that each block of the block diagrams and / or flowcharts, and combinations of blocks in the block diagrams and / or flowcharts, can be implemented by a dedicated hardware-based system that performs the specified functions or acts, or by a combination of dedicated hardware and computer instructions.

[0071] The embodiments of the present disclosure have been described above. The above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The choice of terms used herein is intended to best explain the principles of the embodiments, the practical application, or improvements made to the technology in the market, or to enable other ordinary skilled persons in the art to understand the embodiments disclosed herein.

Claims

1. An electrode device for conducting in-vivo experiments on ovarian tumors in animals, wherein, the electrode device includes first to fourth connection terminals, first to fourth conductive cables, a conductive slip ring, first to fourth wires, and first and second electrode patches adapted to be applied to an animal with an ovarian tumor; the first ends of the first to fourth conductive cables are electrically connected to the first end of the conductive slip ring, and the first ends of the first to fourth wires are electrically connected to the second end of the conductive slip ring. The conductive slip ring is configured such that the first to fourth conductive cables are rotatably and electrically connected to the first to fourth wires respectively, to form first to fourth signal transmission lines; the first to fourth connection terminals are adapted to be plugged into an electric field generator assembly. The second ends of the first to fourth conductive cables are electrically connected to the first to fourth connection terminals respectively. The second ends of the first and third wires are electrically connected to the first electrode patch, and the second ends of the second and fourth wires are electrically connected to the second electrode patch. Such that a first alternating electric signal generated by the electric field generator assembly at a first time and a third alternating electric signal generated at a second time can be transmitted to the first electrode patch via the first signal transmission line and the third signal transmission line respectively, and a second alternating electric signal generated by the electric field generator assembly at the first time and a fourth alternating electric signal generated at the second time can be transmitted to the second electrode patch via the second signal transmission line and the fourth signal transmission line respectively. The second alternating electric signal has a polarity opposite to that of the first alternating electric signal, and the fourth alternating electric signal has a polarity opposite to that of the third alternating electric signal.

2. The electrode device according to claim 1, wherein, the first electrode patch is adapted to be applied to a first position on the animal associated with the ovarian tumor, and the second electrode patch is adapted to be applied to a second position on the animal associated with the ovarian tumor, so as to form a first alternating electric field between the first position and the second position when the first electrode patch and the second electrode patch receive the first alternating electric signal and the second alternating electric signal respectively, and to form a second alternating electric field between the first position and the second position when the first electrode patch and the second electrode patch receive the third alternating electric signal and the fourth alternating electric signal respectively.

3. The electrode device according to claim 2, wherein, the formed first alternating electric field and the formed second alternating electric field are perpendicular to each other.

4. The electrode device according to claim 3, wherein, The first electrode patch includes a first transducer assembly and a second transducer assembly, and the second electrode patch includes a third transducer assembly and a fourth transducer assembly. The first electrode patch is arranged such that the first transducer assembly is closer to the conductive slip ring than the second transducer assembly, and the second electrode patch is arranged such that the third transducer assembly is closer to the conductive slip ring than the fourth transducer assembly. The first electrode patch is electrically connected to the first wire via the first transducer assembly to receive a first alternating electrical signal, and is electrically connected to the third wire via the second transducer assembly to receive a third alternating electrical signal. Moreover, the second electrode patch is electrically connected to the fourth wire via the third transducer assembly to receive a fourth alternating electrical signal, and is electrically connected to the second wire via the fourth transducer assembly to receive a second alternating electrical signal.

5. The electrode device according to claim 4, wherein, the first transducer assembly is electrically connected to the first wire at a first end of its side facing the conductive slip ring, the second transducer assembly is electrically connected to the third wire at a second end of its side facing the conductive slip ring, and the third transducer assembly is electrically connected to the fourth wire at a first end of its side facing the conductive slip ring, and the fourth transducer assembly is electrically connected to the second wire at a second end of its side facing the conductive slip ring.

6. The electrode device according to claim 4, wherein, the animal is a mouse, and the distance between the first transducer assembly and the second transducer assembly is less than or equal to 10 mm, and the distance between the third transducer assembly and the fourth transducer assembly is also less than or equal to 10 mm.

7. The electrode device according to claim 2 or 3, wherein, the first position and the second position are selected such that both the first alternating electric field and the second alternating electric field can pass through the ovarian tumor.

8. The electrode device according to claim 2, wherein, the first time and the second time occur alternately, and both the first time and the second time are periodic.

9. The electrode device according to claim 1, wherein, the total lengths of the first conductive cable and the first wire, the second conductive cable and the second wire, the third conductive cable and the third wire, and the fourth conductive cable and the fourth wire are selected such that the corresponding first to fourth signal transmission lines do not interfere with the free movement of the animal within a predetermined range.

10. The electrode device according to claim 1, wherein, each of the first and second electrode patches includes: a first and a second adhesive member, a support body, a first and a second transducer assembly, and a flexible support layer; the support body includes a first through hole whose shape is adapted to the first transducer and a second through hole whose shape is adapted to the second transducer. The first transducer assembly is fixedly embedded in the first through hole, and the second transducer is fixedly embedded in the second through hole; The first surface of the first adhesive is pasted on the first surface of the first transducer assembly in a manner covering the first through hole, and the second surface of the first adhesive is adapted to be used as an application layer to be applied on the animal; The first surface of the second adhesive is pasted on the first surface of the second transducer assembly in a manner covering the second through hole, and the second surface of the second adhesive is also adapted to be used as an application layer to be applied on the animal; and The flexible support layer is attached to the surface of the support body away from the adhesive, the second surface of the first transducer assembly, and the second surface of the second transducer assembly.

11. The electrode device according to claim 10, wherein, each of the transducer assemblies includes: a reinforcing plate, a flexible printed circuit board, and a ceramic chip, the flexible printed circuit board is disposed on the reinforcing plate, and the flexible printed circuit board includes a main body portion and a protruding portion, and a first conductive pad is disposed on the main body portion, and a second conductive pad is disposed on the protruding portion, the first conductive pad and the second conductive pad are electrically connected to each other, the ceramic chip is welded to the flexible printed circuit board through the first conductive pad, and a corresponding one of the first to fourth wires is welded to the flexible printed circuit board through the second conductive pad to electrically connect the wire to the electrode patch where the transducer assembly is located.

12. The electrode device according to claim 10, further comprising a medical tape configured to fix the wire connected to the corresponding electrode patch on the flexible support layer of the electrode patch.

13. The electrode device according to claim 10, wherein, both the first adhesive and the second adhesive are made of conductive hydrogel, the support body is made of foam material, and the flexible support layer is made of non-woven fabric.

14. The electrode device according to claim 11, wherein, the reinforcing plate is made of epoxy glass cloth.

15. A method for determining the application position of an electrode device on an animal, the electrode device being the electrode device according to any one of claims 1-14, the method comprises: acquiring a three-dimensional simulation model of the trunk part of the animal, the trunk part including the ovarian tumor; constructing a corresponding first simulation electrode patch and a second simulation electrode patch for the first electrode patch and the second electrode patch respectively, and setting a first simulation alternating signal and a second simulation alternating signal for the first simulation electrode patch and the second simulation electrode patch respectively, the first simulation alternating signal and the second simulation alternating signal having opposite polarities; based on the three-dimensional simulation model, determining a plurality of candidate application position combinations for applying the first simulation electrode patch and the second simulation electrode patch on the three-dimensional simulation model, each candidate application position combination including a first candidate application position for applying the first simulation electrode patch and a second candidate application position for applying the second simulation electrode patch; For each candidate patch position combination, determine the intensity of the alternating electric field formed between the first simulated electrode patch and the second simulated electrode patch when the first simulated electrode patch is disposed at the corresponding first candidate patch position and the second simulated electrode patch is disposed at the corresponding second candidate patch position; and determine the first candidate patch position and the second candidate patch position in the candidate patch position combination corresponding to the determined maximum intensity as the final patch positions, so as to determine the positions on the animal body for applying the first electrode patch and the second electrode patch respectively based on the final patch positions and the three-dimensional simulation model.

16. The method according to claim 15, wherein based on the three-dimensional simulation model, a plurality of candidate patch position combinations for applying the first simulated electrode patch and the second simulated electrode patch on the three-dimensional simulation model are determined comprising: determining the plurality of candidate patch position combinations based on the position and size of the ovarian tumor in the three-dimensional simulation model and the sizes of the first simulated electrode patch and the second simulated electrode patch.

17. The method according to claim 15, wherein the three-dimensional simulation model is constructed by the following steps: acquiring tomographic scan images of the trunk part of the animal; and generating the three-dimensional simulation model based on the tomographic scan images.

18. The method according to claim 15, wherein the size ratio relationship between the three-dimensional simulation model and the trunk part is the same as the size ratio relationship between the first and second electrode patches and the first and second simulated electrode patches respectively.

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