Integrated non-invasive AD treatment monitoring system
Through the integrated non-invasive AD treatment monitoring system, combined with multiple treatment methods and real-time monitoring functions, the existing AD treatment technology has solved the problems of single functions and lack of real-time monitoring, and achieved more efficient and intelligent treatment effects.
Patent Information
- Application Number
- CN202510283448.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-11
- Publication Date
- 2025-06-03
AI Technical Summary
The existing Alzheimer's disease (AD) treatment technology has problems such as single functions, lack of real-time monitoring, complex operation, low intelligence level, limited data storage and analysis capabilities, and poor portability, resulting in unsatisfactory treatment results and difficulty in popularizing them.
An integrated non-invasive AD treatment monitoring system is designed, including AD treatment helmets, physiotherapy wheelchairs and remote terminals, combining photoacoustic stimulation, transcranial magnetic therapy, Doppler ultrasound probes and other treatment methods, and is equipped with real-time monitoring and automatic adjustment functions.
It realizes diversified treatment methods and comprehensive real-time monitoring functions, improves the transparency and adjustability of treatment effects, reduces operational complexity and intelligence level, enhances data storage and analysis capabilities, and improves portability and comfort.
Smart Images
Figure CN120079045A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of treatment devices for neurodegenerative diseases, and particularly to an integrated non-invasive AD treatment monitoring system. Background Art
[0002] With the aging of the population, the incidence of neurodegenerative diseases such as Alzheimer's disease (AD) has been increasing year by year. At present, the treatment methods for AD are limited and the effects are not satisfactory. In recent years, research has shown that by promoting cerebrospinal fluid (CSF) flow and improving the clearance of metabolic waste, the symptoms of AD can be effectively alleviated.
[0003] The diagnosis and treatment of Alzheimer's disease (AD) still face a series of challenges at present. This disease is difficult to be identified in time at the early stage, resulting in the delay of treatment. Secondly, the current diagnostic methods are often invasive, which not only brings additional physical burden to patients, but also limits their feasibility in routine examinations. In addition, the repeatability of existing detection methods is not satisfactory, making the continuous monitoring of the condition complicated. Moreover, the high examination cost makes it difficult for many patients to bear, thus affecting the popularization and continuity of treatment. In the existing treatment technologies, the methods for promoting CSF flow and metabolic waste clearance are mostly single stimuli, with limited effects, and cannot achieve multi-faceted real-time monitoring during the treatment process, so the treatment parameters cannot be adjusted in time, greatly reducing the treatment effect.
[0004] Therefore, there is an urgent need to research and develop a new type of non-invasive detection and regulation device, which should have high sensitivity and specificity, and be able to accurately identify the presence of the disease at the early stage of the disease course. At the same time, it should also be able to provide stable and reliable detection results for doctors and researchers to effectively monitor the progress of the condition. In addition, the cost-effectiveness of the device is also an important consideration in its design to ensure that a wide range of patient groups can obtain timely diagnosis and necessary treatment. The development of this device is expected to break through the limitations of existing diagnostic technologies and provide strong support for the early intervention and long-term management of Alzheimer's disease.
[0005] Recently, numerous scientific studies have found that the use of photobiomodulation technology combined with photoacoustic stimulation has a significant effect on improving the function of meningeal lymphatics. In particular, irradiation of the head with near-infrared light with a wavelength of 808 nanometers, supplemented by auditory and visual stimulation at 40 hertz, can promote the metabolic process of brain waste, which provides a new idea for the treatment of Alzheimer's disease (AD). However, considering the diversity of symptoms and individual differences among AD patients, it becomes particularly crucial to determine the parameters of near-infrared light and photoacoustic stimulation that are most suitable for patients.
[0006] During the treatment process, changes in the flow properties of cerebrospinal fluid will further affect the overall hemodynamic state of the brain. Doppler Ultrasound Detection, as a non-invasive method, is commonly used to monitor subtle changes in hemodynamics. In the treatment of AD, by real-time monitoring of key physiological indicators such as blood flow velocity and its fluctuations, pupil response, conjunctival congestion, heart rate, and blood oxygen saturation in the patient's brain, the treatment effect can be comprehensively evaluated, and the parameters of the treatment device can be adjusted accordingly to achieve the optimal treatment effect.
[0007] In the field of Alzheimer's disease (AD) treatment, current technologies have some limitations that affect the maximization of treatment effects. These limitations are specifically reflected in the following aspects: (1) Existing non-invasive devices on the market often have a single function and lack diverse treatment means: These devices usually can only provide a single stimulation method to promote the flow of cerebrospinal fluid and the clearance of metabolic waste. This single method is not very effective. In addition, these devices lack comprehensive real-time monitoring functions during the treatment process and cannot adjust treatment parameters in a timely manner, thus limiting the treatment effect. (2) During the treatment process, there is a lack of comprehensive real-time monitoring capabilities. (3) The operation is complex and the level of intelligence is insufficient. (4) The existing devices also have relatively limited capabilities in data storage and analysis. (5) The portability of the devices is poor, restricting the user's freedom of movement and potentially causing discomfort during the treatment process. Summary of the Invention
[0008] To solve the above problems, the present invention provides an integrated non-invasive AD treatment monitoring system.
[0009] The purpose of the present invention is to provide an integrated non-invasive AD treatment monitoring system, including: an AD treatment helmet, a physiotherapy wheelchair, and a remote terminal; the AD treatment helmet is fixedly connected to the physiotherapy wheelchair in a detachable manner; The AD treatment helmet includes a helmet body, and a photoacoustic stimulation unit, a transcranial magnetic stimulation module, and a Doppler ultrasound probe provided on the helmet body; the photoacoustic stimulation unit includes a visual stimulation module and auditory stimulation headphones for promoting gamma neural oscillations in the brain; the visual stimulation module is provided at the front end of the helmet body for inducing a hemodynamic response in the cerebral cortex and triggering neural activities; there are 2 auditory stimulation headphones, and the 2 auditory stimulation headphones are respectively provided on both sides of the helmet body corresponding to the ear positions; each auditory stimulation headphone is connected to 1 Doppler ultrasound probe; the transcranial magnetic stimulation module includes six magnetic therapy heads distributed at different positions on the helmet body. The six magnetic therapy heads are respectively 1 head-top magnetic therapy head, 1 forehead magnetic therapy head, 2 temple magnetic therapy heads, and 2 posterior brain magnetic therapy heads; the head-top magnetic therapy head corresponds to the Baihui acupoint, the forehead magnetic therapy head corresponds to the Shenting acupoint, the temple magnetic therapy heads correspond to the Hanyan acupoint, and the posterior brain magnetic therapy heads correspond to the Fengchi acupoint respectively; The physiotherapy wheelchair is equipped with a seat, a massager, a touch display screen, a computer host, a cardiovascular monitoring component, and adjustment buttons; the touch display screen is installed on one side of the physiotherapy wheelchair, and the computer host is arranged under the backrest of the physiotherapy wheelchair; the touch display screen is electrically connected to the computer host; the cardiovascular monitoring component and the adjustment buttons are arranged on the armrest of the physiotherapy wheelchair; there are two massagers, and the two massagers correspond to the cervical and lumbar positions respectively; the massager is provided with phototherapy lamp beads for promoting human blood circulation and metabolism and assisting in the treatment of Alzheimer's disease; the cardiovascular monitoring component monitors the cardiovascular status of the patient in real time; the adjustment buttons adjust the intensity of the phototherapy lamp beads; The remote terminal is connected to the computer host by a wireless or wired connection method, and is used to view or adjust treatment parameters, and freely control the switches of each module.
[0010] Preferably, a helmet tightening knob is provided at the front end of the helmet body, and a buckle is provided at the rear end; the visual stimulation module is arranged under the helmet tightening knob; The visual stimulation module includes glasses, and sliding grooves are provided on both sides of the glasses; one end of the sliding groove is fixedly connected to the glasses, and the other end is fixedly connected to the buckle; the glasses are provided with transparent LED pulsed light lenses, and the transparent LED pulsed light lenses display an inverted flashing radial checkerboard pattern as visual stimulation; the glasses are AR glasses or MR glasses.
[0011] Preferably, the flashing frequency range of the glasses is 1 Hz to 20 Hz; An ultra-high-definition monitoring camera is provided above the transparent LED pulsed light lens, and the ultra-high-definition monitoring camera is used to obtain the eye information of the patient; The sliding groove is arc-shaped; the glasses and the buckle form an annular headband through the two sliding grooves, and the annular headband corresponds to the horizontal plane of the head's eyebrow bone.
[0012] Preferably, 2 elastic bands are further provided on the helmet body, and both sides of the cranial magnetic therapy head are respectively connected to the glasses of the visual stimulation module and the buckle behind the helmet body through the elastic bands; a number of optical fiber interfaces are provided on the 2 elastic bands; A card seat is provided on the elastic band, the card seat is connected to the transcranial magnetic therapy module and is connected to the buckle behind the helmet body; the helmet tightening knob adjusts the length and tightness of the elastic band for fixing the AD treatment helmet on the patient's head; The optical fiber output interface on the physiotherapy wheelchair is connected to the optical fiber interface through an optical fiber, and the near-infrared laser from the physiotherapy wheelchair is transmitted to the optical fiber interface, and the laser is emitted through the optical fiber interface to irradiate the meningeal lymphatic vessel site of the patient to realize the phototherapy function; The magnetic therapy vibration frequencies of the six magnetic therapy heads of the transcranial magnetic therapy module are all 2 to 10 Hz.
[0013] Preferably, a helmet tightening knob is provided at the front end of the helmet body, and a buckle is provided at the rear end; the visual stimulation module is provided below the helmet tightening knob; sliding grooves are provided on both sides of the visual stimulation module; There are 2 auditory stimulation earphones, and the 2 auditory stimulation earphones are respectively arranged on both sides of the helmet body, corresponding to the ear positions; the auditory stimulation earphones are slidably connected to the sliding grooves to ensure sliding on the sliding grooves; each auditory stimulation earphone is connected to 1 Doppler ultrasound probe, and the Doppler ultrasound probe is arranged above the auditory stimulation earphone.
[0014] Preferably, a helmet card slot is provided below the auditory stimulation earphone, and the helmet card slot is used to connect the physiotherapy wheelchair or other expansion devices; A plurality of sliding groove positioning ridges are provided in the sliding grooves, and after the relative positions of the 2 temple magnetotherapy heads, the 2 posterior brain magnetotherapy heads and the auditory stimulation earphones are adjusted, they can be kept stable through the sliding groove positioning ridges.
[0015] Preferably, a helmet power supply interface is further provided below the rear side of the helmet body; the glasses, the transcranial magnetic therapy module, the auditory stimulation earphones and the Doppler ultrasound probe are connected to the helmet power supply interface through cables.
[0016] Preferably, a lifting fixing rod, a lifting sliding groove and a translation sliding groove are further provided on the physiotherapy wheelchair; The lifting fixing rod, the lifting sliding groove and the translation sliding groove are arranged behind the backrest of the physiotherapy wheelchair; the touch display screen is installed on one side of the physiotherapy wheelchair, and the computer main unit is arranged below the backrest of the physiotherapy wheelchair; the touch display screen is electrically controlled and connected to the computer main unit; A helmet card slot is provided below the auditory stimulation earphone; the lifting fixing rod is movably connected to the helmet card slot in a detachable manner; the AD treatment helmet can be freely adjusted in height position up and down and fixed through the telescopic movement of the lifting fixing rod, and by moving the horizontal relative position of the helmet card slot and the lifting fixing rod, it is ensured that the AD treatment helmet adapts to different users and reduces the neck pressure of the users; The upper and lower ends of the lifting sliding groove are fixed on the frame of the physiotherapy wheelchair; there are two translation sliding grooves, and the two translation sliding grooves are arranged in parallel on the lifting sliding groove; Massager racks are provided on both of the two massagers, and the two massagers are fixed on the lifting sliding groove through the massager racks; the massager racks enable the massagers to freely move up, down, left and right on the lifting sliding groove for adjusting the massage position; four pairs of lamp beads are provided on the massage empty groove in the center of the massager, and each pair of lamp beads includes 1 red light therapy lamp bead and 1 far-infrared light therapy lamp bead; the red light therapy lamp bead and the far-infrared light therapy lamp bead act together to promote blood circulation and metabolism throughout the body and assist in the treatment of Alzheimer's disease.
[0017] Preferably, the blood monitoring component includes a blood oxygen measurer and a heart rate sensor; The blood oxygen measurer is a three-channel blood oxygen measurer, and the blood oxygen measurer is located at the armrest of the physiotherapy wheelchair; the heart rate sensor is arranged between the adjustment button and the blood oxygen measurer; when the patient grasps the heart rate sensor for heart rate measurement, the wrist and arm press on the blood oxygen measurer for blood oxygen test. The heart rate sensor and the blood oxygen measurer monitor the patient's cardiovascular status in real time, so as to comprehensively judge the patient's physiological response during the treatment process and ensure the safety and effectiveness of the treatment; The adjustment button is used to adjust the intensities of the red light therapy lamp beads and the far-infrared light therapy lamp beads; The red light therapy lamp beads are red light lamp beads with a wavelength of 630 nm; the far-infrared light therapy lamp beads are far-infrared light lamp beads with a wavelength of 11 μm.
[0018] Preferably, the computer mainframe is provided with a power access terminal, a power output interface, a device switch, and an optical fiber output interface; The power access terminal of the computer mainframe is connected to the commercial power to supply power to the system; a power output interface is arranged on one side of the computer mainframe, and the power output interface is connected to the helmet power supply interface on the helmet main body through a cable to provide power support for each component on the AD treatment helmet and ensure the normal operation of the device; the device switch is arranged on one side of the computer mainframe, and the device switch is used to control the power on and off of the entire system, facilitating the patient and the caregiver to operate the start and stop of the device; The touch display screen displays the treatment effect and provides adjustable options for treatment parameters, is used to perform real-time analysis and processing on various data collected during the treatment monitoring process, and displays the results to the caregiver to facilitate timely adjustment of the treatment plan.
[0019] Compared with the prior art, the present invention can achieve the following beneficial effects: (1) Diversified treatment means: This system combines various treatment methods such as photothermal massage, visual and auditory stimulation, transcranial magnetic stimulation, and near-infrared light stimulation to promote cerebrospinal fluid flow and metabolic waste clearance, providing a more comprehensive treatment effect; (2) Comprehensive real-time monitoring function: The photoacoustic measurement and cerebral hemodynamics imaging components built into this system can continuously track the blood flow dynamics of the patient's brain and combine physiological indicators such as heart rate and blood oxygen saturation to provide intuitive feedback to the therapist, ensuring the transparency of the treatment process and timely adjustment of the treatment plan; (3) High intelligence: This system can automatically adjust treatment parameters, optimize the treatment effect based on monitoring data, reduce the dependence on manual adjustment by the therapist, and improve the intelligence level.
[0020] (4) Powerful data storage and analysis capabilities: This system can store the data collected during the treatment process in the device's hard disk, facilitating later analysis by the therapist, accurately evaluating the treatment effect, and adjusting the treatment plan.
[0021] (5) Optimized portability and comfort: This system is integrated with a wheelchair, allowing users to easily adjust the positions of the treatment helmet and the infrared massager, effectively alleviating the discomfort suffered by patients when using the device. At the same time, the mobility convenience of patients is considered. Moreover, the settings of the massager enhance the curative effect on the one hand and greatly improve the patient's experience of using the device on the other hand.
[0022] (6) Integrated design: A small touch-screen computer is equipped at the rear of the wheelchair, which can perform real-time analysis and processing on various data collected during the treatment monitoring process, and intuitively display the results to the caregiver, facilitating timely adjustment of the treatment plan.
[0023] (7) Humanized freedom adjustment settings: The components in this system have a high degree of freedom. The elastic band and buckle behind the helmet can ensure the displacement and fixation of the magnetic therapy head and the optical fiber head; the headband part of the helmet can be adjusted in size through the knob above the AR glasses, and the headband is provided with a slider to ensure that the magnetic therapy heads are distributed at the correct sites; the earphones and the Doppler detector are integrated and can move forward, backward, left, and right along the headband to ensure the correct position; a fixator is provided outside the earphones, which can be connected to the two lifting rods of the wheelchair and can move up and down, forward and backward and be fixed, ensuring the accurate treatment site while reducing the neck pressure on the patient; the neck and lumbar massagers on the wheelchair can also move freely up and down to ensure the best treatment experience for the patient.
[0024] In summary, the present invention provides an integrated non-invasive AD treatment monitoring system, abbreviated as Glioflo. Glioflo combines "gli" (glia) and "flo" (flow). This system can accurately regulate treatment parameters and real-time monitor the physiological responses of patients to ensure the safety and effectiveness of the treatment. Through this comprehensive method, personalized treatment plans can be provided for AD patients, thereby maximizing the treatment response rate and improving the quality of life of patients. It represents the characteristic that the device promotes the flow of the glymphatic system in the brain. BRIEF DESCRIPTION OF THE DRAWINGS
[0025] Figure 1 is a front axonometric view of the AD treatment helmet structure in the integrated non-invasive AD treatment monitoring system provided by an embodiment of the present invention; Figure 2 is a rear view of the AD treatment helmet structure in the integrated non-invasive AD treatment monitoring system provided by an embodiment of the present invention; Figure 3It is the overall schematic diagram of the integrated non-invasive AD treatment monitoring system provided by the embodiments of the present invention; Figure 4 It is the front view of the integrated non-invasive AD treatment monitoring system provided by the embodiments of the present invention; Figure 5 It is the rear view of the integrated non-invasive AD treatment monitoring system provided by the embodiments of the present invention; Figure 6 It is the enlarged partial rear view of the integrated non-invasive AD treatment monitoring system provided by the embodiments of the present invention; Figure 7 It is the top view of the integrated non-invasive AD treatment monitoring system provided by the embodiments of the present invention; Figure 8 It is the enlarged view of the armrest part of the integrated non-invasive AD treatment monitoring system provided by the embodiments of the present invention.
[0026] Reference numerals: 1. Helmet main body; 11. Helmet tightening knob; 12. Buckle; 13. Slide groove; 14. Elastic band; 15. Optical fiber interface; 16. Helmet card slot; 17. Helmet power supply interface; 131 Slide groove positioning convex edge; 2. AR glasses; 21. Transparent LED pulsed light lens; 22. Ultra-high definition monitoring camera; 31. Top of head magnetic therapy head; 32. Forehead magnetic therapy head; 33. Temple magnetic therapy head; 34. Back of head magnetic therapy head; 4. Auditory stimulation earphone; 5. Doppler ultrasound probe; 6. AD treatment helmet; 7. Physiotherapy wheelchair; 71. Lifting fixed rod; 73. Lifting slide groove; 74. Translation slide groove; 75. Massager; 76. Touch display screen; 77. Computer mainframe; 79. Adjustment button; 751. Massager rack; 752. Second phototherapy lamp bead; 753. Third phototherapy lamp bead; 772. Power output interface; 773. Equipment switch; 774. Optical fiber output interface; 781. Blood oxygen measurer; 782. Heart rate sensor. Detailed implementation manners
[0027] In the following, embodiments of the present invention will be described with reference to the accompanying drawings. In the following description, the same modules are denoted by the same reference numerals. In the case of the same reference numerals, their names and functions are also the same. Therefore, their detailed descriptions will not be repeated.
[0028] In order to make the objectives, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and do not constitute a limitation to the present invention.
[0029] Referring to Figures 1 - 8 , the present invention provides an integrated non-invasive AD treatment monitoring system, including: an AD treatment helmet 6, a physiotherapy wheelchair 7, and a remote terminal 8; As Figures 1 - 2 shown, the AD treatment helmet 6 includes a helmet main body 1, and a photoacoustic stimulation unit, a transcranial magnetic therapy module, and a Doppler ultrasound probe 5 provided on the helmet main body 1; The photoacoustic stimulation unit includes a visual stimulation module and an auditory stimulation earphone 4; the sound wave output by the auditory stimulation earphone 4 and the visual stimulation module constitute a 40 Hz photoacoustic stimulation unit; the photoacoustic stimulation unit can promote gamma neural oscillations in the brain, thereby activating the release of specific neuropeptides and enhancing the clearance function of the glymphatic system in the brain, which helps to reduce amyloid deposition in Alzheimer's disease.
[0030] A helmet tightening knob 11 is provided at the front end of the helmet main body 1, and a buckle 12 is provided at the rear end; The visual stimulation module uses light flashes at a frequency of 40 Hz and an intensity of 4000 lux, which is equivalent to the level of normal indoor lighting, sufficient to cause visual perception but not overly dazzling, and can promote gamma neural oscillations in the brain and enhance the clearance function of the glymphatic system in the brain; the visual stimulation module is provided below the helmet tightening knob 11; the visual stimulation module includes AR glasses 2 (or MR glasses), and sliding grooves 13 are provided on both sides of the AR glasses 2; one end of the sliding groove 13 is fixedly connected to the AR glasses 2, and the other end is fixedly connected to the buckle 12; In a specific embodiment, both sliding grooves 13 are arc-shaped; that is, the AR glasses 2 and the buckle 12 form an annular headband through the two sliding grooves 13, and the annular headband corresponds to the horizontal plane of the head's eyebrow bone.
[0031] The AR glasses 2 are provided with transparent LED pulsed light lenses 21, and the transparent LED pulsed light lenses 21 display an inverted flashing radial checkerboard pattern as visual stimulation, and the flashing frequency range is adjustable, and the frequency range is 1 Hz to 20 Hz; the AR glasses 2 can also adjust the brightness, which is convenient for the user to observe the external field of view; The AR glasses 2 can be replaced with MR glasses according to requirements; the visual stimulation module can induce hemodynamic responses in the cerebral cortex, and the induced neural activities can cause significant changes in cerebrospinal fluid flow, thus assisting in treatment; above the transparent LED pulsed light lens 21, there is a super-high-definition monitoring camera 22 for obtaining patient eye information, such as: the first eye information, the change in conjunctival congestion; the second eye information, the change in pupil size; the third eye information, the blink frequency; these eye information can not only be used to judge the patient's adaptation to visual, light and sound stimuli, but also be combined with the cerebral blood flow information obtained by the Doppler ultrasound probe 5 to comprehensively judge the change in cerebral blood flow with the flow of cerebrospinal fluid, providing multi-dimensional data support for the evaluation of treatment effects.
[0032] The transcranial magnetic therapy module includes six magnetic therapy heads, which are distributed at different positions of the helmet main body 1 and correspond to the Baihe acupoint, Shenting acupoint, Hanyan acupoint, and Fengchi acupoint respectively; the six magnetic therapy heads are 1 top magnetic therapy head 31, 1 forehead magnetic therapy head 32, 2 temple magnetic therapy heads 33, and 2 posterior brain magnetic therapy heads 34; The forehead magnetic therapy head 32 is fixed at the connection of the front ends of the two chutes 13, and the forehead magnetic therapy head 32 corresponds to the Shenting acupoint on the head; the two temple magnetic therapy heads 33 and the two posterior brain magnetic therapy heads 34 are respectively arranged on the two chutes 13 and can slide on the chutes 13; the two temple magnetic therapy heads 33 respectively correspond to the Hanyan acupoints on the head, and the two posterior brain magnetic therapy heads 34 respectively correspond to the Fengchi acupoints on the head; There are Baihe acupoint, Shenting acupoint, Hanyan acupoint, and Fengchi acupoint on the human head; the Baihe acupoint is located on the top of the head; the Shenting acupoint is located on the forehead of the head; there are two Hanyan acupoints, and the two Hanyan acupoints are respectively at the temple on both sides of the head; there are two Fengchi acupoints, and the two Fengchi acupoints are on both sides of the back of the head; the positions of the top magnetic therapy head 31, the forehead magnetic therapy head 32, the temple magnetic therapy heads 33, and the posterior brain magnetic therapy heads 34 are adapted to the distribution of human head acupoints, and are respectively arranged on the top, front end, side and rear end of the helmet main body 1; Although there are certain individual differences in the skulls and acupoints of different people, acupoints can be located relatively accurately through some methods such as body surface landmarks and bone measurement methods: (1) Baihe Point: The standardized name is Baihui Point, which is located on the head, 5 cun directly above the midpoint of the anterior hairline; Simple method for finding the point: The intersection of the line connecting the tips of the two ears upward and the midline of the head is this point. (2) Shenting Point: On the head, 0.5 cun directly above the midpoint of the anterior hairline; When simply finding the point, first find the anterior hairline, and then measure about half a finger width upward from the midline, which is the Shenting Point. (3) Hanyan Point: On the head, on the arc connecting Touwei Point and Qubin Point, 2 finger widths below Touwei Point. Touwei Point is located 0.5 cun above the hairline at the frontal angle, 4.5 cun lateral to the midline of the head; Qubin Point is directly above the posterior margin of the sideburns in front of the ear, level with Jiaosun Point. (4) Fengchi Point: In the posterior cervical region, below the occipital bone, in the depression between the upper ends of the sternocleidomastoid muscle and the trapezius muscle. When sitting upright with the head down, there is a depression on each side below the high bone (mastoid process) behind the ear.
[0033] The top magnetic therapy head 31, the front magnetic therapy head 32, the temple magnetic therapy head 33, and the back magnetic therapy head 34 have the same structure and are all magnetic therapy vibration devices; The magnetic therapy vibration frequencies of the top magnetic therapy head 31, the front magnetic therapy head 32, the temple magnetic therapy head 33, and the back magnetic therapy head 34 are adjustable between 2 and 10 Hz.
[0034] There are also 2 elastic bands 14 provided on the helmet main body 1. The two sides of the top magnetic therapy head 31 are respectively connected to the AR glasses 2 and the buckle 12 through the elastic bands 14; A number of optical fiber interfaces 15 are provided on both of the 2 elastic bands 14; A card holder is provided on the elastic band 14. The card holder can be connected to the transcranial magnetic therapy module and the optical fiber, and is connected to the buckle 12 at the rear of the helmet main body 1; The helmet tightening knob 11 adjusts the length and tightness of the elastic band 14, plays a role in fixing the helmet on the patient's head, and makes the transcranial magnetic therapy module and the optical fiber interface 15 closely adhere to the patient's scalp.
[0035] There are 2 auditory stimulation earphones 4 provided. The 2 auditory stimulation earphones 4 are respectively arranged on both sides of the helmet main body 1, corresponding to the ear positions; The auditory stimulation earphones 4 are slidably connected to the sliding groove 13 to ensure sliding on the sliding groove 13; Each auditory stimulation earphone 4 is connected to 1 Doppler ultrasound probe 5, and the Doppler ultrasound probe 5 is arranged above the auditory stimulation earphone 4; The auditory stimulation earphone 4 can output sound waves with a frequency of 40 Hz and 60 decibels for auditory stimulation; A helmet card slot 16 is provided below the auditory stimulation earphone 4, and the helmet card slot 16 facilitates the equipment expansion or fixed connection of the helmet main body 1; A plurality of sliding groove positioning ridges 131 are provided in the sliding groove 13. After the 2 temple magnetic therapy heads 33, the 2 back magnetic therapy heads 34, and the auditory stimulation earphones 4 adjust their relative positions, they can be kept stable through the sliding groove positioning ridges 131.
[0036] There is also a helmet power supply interface 17 provided below the rear side of the helmet main body 1; the AR glasses 2, the transcranial magnetic therapy module, the auditory stimulation headphones 4, and the Doppler ultrasound probe 5 are connected to the helmet power supply interface 17 through cables.
[0037] The frame body of the physiotherapy wheelchair 7 is similar to the structure of the existing wheelchair main body; there are main traveling wheels and auxiliary traveling wheels provided below the physiotherapy wheelchair 7, and a seat is provided on the physiotherapy wheelchair 7; On the physiotherapy wheelchair 7, there are a lifting fixing rod 71, a lifting chute 73, a translation chute 74, a massager 75, a touch display screen 76, a computer main unit 77, a blood circulation monitoring component, and adjustment buttons 79; the lifting fixing rod 71, the lifting chute 73, and the translation chute 74 are provided behind the backrest of the physiotherapy wheelchair 7; the touch display screen 76 is installed on one side of the physiotherapy wheelchair 7, and the computer main unit 77 is provided below the backrest of the physiotherapy wheelchair 7; the touch display screen 76 is electrically and controllably connected to the computer main unit 77; The lifting fixing rod 71 is movably connected to the helmet card slot 16 in a detachable manner; the lifting fixing rod 71 is used to fix the AD treatment helmet 6, and the AD treatment helmet 6 can freely adjust its height position up and down and be fixed through the telescoping of the lifting fixing rod. By moving the horizontal relative position between the helmet card slot 16 and the lifting fixing rod 71, it is ensured that the AD treatment helmet 6 adapts to different users and reduces the neck pressure of the user, and it is ensured that the AD treatment helmet 6 can stably improve the comfort of the patient during the treatment process; The upper and lower ends of the lifting chute 73 are fixed on the frame of the physiotherapy wheelchair 7; there are two translation chutes 74, and the two translation chutes 74 are arranged in parallel on the lifting chute 73.
[0038] There are two massagers 75, and massage racks 751 are provided on both of the two massagers 75. The two massagers 75 are fixed on the lifting chute 73 through the massage racks 751; the massage racks 751 enable the massagers 75 to freely move up, down, left, and right on the lifting chute 73, facilitating the patient to adjust the massage position to adapt to the physical conditions and needs of different patients; The two massagers 75 correspond to the cervical vertebra and the lumbar vertebra respectively; there are four pairs of lamp beads on the massage empty slots in the center of the massager 75, and each pair of lamp beads includes 1 second phototherapy lamp bead 752 and 1 third phototherapy lamp bead 753; the second phototherapy lamp bead 752 is a red light bead with a wavelength of 630 nm; the third phototherapy lamp bead 753 is a far-infrared light bead with a wavelength of 11 μm; the second phototherapy lamp bead 752 and the third phototherapy lamp bead 753 act together to promote blood circulation throughout the body, improve cerebral hemodynamics, and promote meningeal lymphatic drainage; through the photothermal effect, it promotes blood circulation and metabolism of the body and assists in the treatment of Alzheimer's disease.
[0039] On the computer main unit 77, there are a power access terminal, a power output interface 772, a device switch 773, and an optical fiber output interface 774; The power input terminal of the computer main unit 77 is connected to the mains power supply to power this non-invasive AD treatment system; on one side of the computer main unit 77, there is a power output interface 772, and the power output interface 772 is connected to the helmet power supply interface 17 through a cable; the power output interface 772 powers the AD treatment helmet 6, and the power output interface 772 provides power support for each component on the AD treatment helmet 6 to ensure the normal operation of the device; The device switch 773 is arranged on one side of the computer main unit 77. The device switch 773 is used to control the power on and off of the entire system, facilitating patients and guardians to operate the start and stop of the device; The fiber optic output interface 774 is connected to the fiber optic interface 15 on the AD treatment helmet 6 through a fiber optic cable, transmitting the 808nm near-infrared laser from the physical therapy wheelchair 7 to the fiber optic interface 15, and then irradiating the meningeal lymphatic vessel site of the patient to achieve the phototherapy function.
[0040] The touch display screen 76 can display the treatment effect and provide options for adjusting treatment parameters; it can perform real-time analysis and processing on various data collected during the treatment monitoring process, and intuitively display the results to the guardian for timely adjustment of the treatment plan; at the same time, the guardian can operate the treatment and detection process through the touch computer and control the on and off of each module.
[0041] The blood and heart monitoring component and adjustment button 79 are arranged on the armrest of the physical therapy wheelchair 7; the blood and heart monitoring component includes a blood oxygen measurer 781 and a heart rate sensor 782; The blood oxygen measurer 781 is a blood oxygen measurer with 3 channels. The blood oxygen measurer 781 is located at the armrest of the physical therapy wheelchair 7; the 3-channel design of the blood oxygen measurer aims to reduce measurement errors by calculating the average curve obtained from the three channels (each channel corresponds to a curve, and the monitoring is carried out in real time); The heart rate sensor 782 is arranged between the adjustment button 79 and the blood oxygen measurer 781; when the patient grasps the heart rate sensor 782 for heart rate measurement, the wrist and arm press on the blood oxygen measurer 781 for blood oxygen test. The heart rate sensor 782 and the blood oxygen measurer 781 monitor the cardiovascular status of the patient in real time to comprehensively judge the physiological response of the patient during the treatment process and ensure the safety and effectiveness of the treatment; The adjustment button 79 adjusts the intensities of the second phototherapy lamp bead 752 and the third phototherapy lamp bead 753.
[0042] The said remote terminal 8 is a computer or a supporting mobile phone. The computer is connected to the computer main unit 77 by wireless or wired connection; a control software (supporting mobile phone APP) is installed on the supporting mobile phone. After the mobile phone is connected to the device via Bluetooth, the treatment parameters can be viewed and adjusted on the mobile phone, and the on and off of each system of the treatment and monitoring modules can be freely controlled. When an abnormality occurs during the treatment process, the device and the mobile phone will vibrate and ring at the same time to remind the guardian or the patient for timely correction.
[0043] Relevant research shows that Doppler ultrasound diagnosis of patients can reveal problems such as memory decline and decreased cerebral blood flow in AD patients at an early stage. This indicates that when the blood flow in the parietal lobe of the elderly decreases, there is a tendency for dementia to occur. At the same time, some scholars' research also found that the presence of cardiovascular and cerebrovascular problems will also accelerate the occurrence of AD. All studies have proved that there is a close connection between brain function disorders and the occurrence of AD. Especially when the blood flow in the temporal lobe and parietal lobe regions decreases, it is very likely to lead to the occurrence of AD. Clinicians should pay great attention to such patients after diagnosis and take relevant measures for treatment. Therefore, in the process of treating AD, the most important thing is to improve the cerebral blood flow of patients, so as to prevent the recurrence of AD. At the same time, early use of ultrasound examination is particularly important for AD patients.
[0044] The blood flow velocity parameters shown in Doppler ultrasound images mainly include: peak systolic velocity Vs, end-diastolic velocity Vd, and mean velocity Vm = (Vs - Vd) / 3 + Vd.
[0045] Weighted operation: (treatment, adaptation) The weight values of each parameter can be adjusted according to the actual situation, as follows: X = a×40% + b×20% + c×10% + d×10% + e×20%; In the formula, X represents the treatment effect value, a represents the average velocity of the Doppler cycle, b represents the change in blood oxygen saturation, c represents the change in heart rate, d represents the change in pupil value, e represents the change in conjunctival congestion; one cycle per Doppler cycle to obtain a score, and a line graph represents the overall monitoring parameter changes during the treatment process); Each treatment parameter (corresponding image) can be displayed separately on the touch screen 76 of the physiotherapy wheelchair 7, or can be switched to the cycle comprehensive score (a line graph after parameter weighted fusion), and the expression is as follows; Y = b×30% + c×30% + f×20% + d×10% + e×10% In the formula, Y represents the fitness value (pressure), b represents the change in blood oxygen saturation, c represents the change in heart rate, d represents the change in pupil value, e represents the change in conjunctival congestion, f represents the blink frequency; one cycle per minute to obtain a score, and a line graph represents the fitness changes during the treatment process; Each treatment parameter (corresponding image) can be displayed separately on the touch screen 76 of the physiotherapy wheelchair 7, or can be switched to the comprehensive score per minute (a line graph after parameter weighted fusion); The fitness value partition includes the one-to-one correspondence between multiple intervals where fitness values are located and the evaluation according to the weighted score. The evaluation can include adaptation (fitness value ≥ 80), relatively good adaptation (fitness value 60 - 80), non - adaptation (fitness value 40 - 60), and severe non - adaptation (fitness value ≤ 40).
[0046] The abnormal conditions during the treatment process are reflected as images corresponding to each treatment parameter. For the real - time monitoring images during the patient's treatment, first, the algorithm (running in real - time) performs signal pre - processing (removing baseline drift, noise, and interference), then locates the key feature points and detects whether the image waveform is abnormal. If there is an abnormality, the algorithm intercepts the abnormal signal, uploads it to the database in real - time, diagnoses it according to the classification, and then feeds back to the computer of the physiotherapy wheelchair 7 to give a warning display, and can upload it to the mobile app through the Bluetooth module (the whole algorithm process is not synchronized with the treatment image, with a delay of about 5 seconds). After the end of a treatment cycle, a report is generated and sent to the engineer, doctor, and equipment operator to facilitate timely communication among the three parties and improve the treatment effect.
[0047] The advantages of the present invention are as follows: (1) To solve the problem of the single non - invasive function of existing AD treatment devices, the system of the present invention is designed to consist of two parts: a wheelchair and a helmet. The wheelchair part is equipped with a photothermal massage function, which helps to promote blood circulation throughout the body, increase blood flow to the brain, improve the metabolic activity of the choroid plexus, and thus increase the production of cerebrospinal fluid and promote its flow. The helmet part combines visual, auditory stimulation, transcranial magnetic stimulation technology, and near - infrared light stimulation, which can promote the dilation of meningeal lymphatic vessels and further promote the flow of cerebrospinal fluid. Through this comprehensive treatment method, the Glioflo device can accelerate the cerebrospinal fluid circulation and absorption of patients, thereby reducing intracranial pressure, improving cerebral hemodynamics, and enhancing the brain's ability to clear metabolic wastes. This treatment method with multi - module collaborative work provides a new treatment option for Alzheimer's disease patients.
[0048] (2) By using the integrated photoacoustic measurement and regulation device in the Glioflo helmet, especially its cerebral hemodynamics imaging component, the blood flow dynamics of the patient's brain can be continuously tracked. In addition, by combining physiological indicators such as heart rate and blood oxygen saturation, the physiological responses of patients during treatment can be comprehensively evaluated. This information is presented in the form of charts through the device interface, providing intuitive feedback for therapists, patients, and their families, helping therapists master the progress of treatment and the immediate status of patients, ensuring the transparency of the treatment process, and allowing timely adjustment of treatment plans to optimize the treatment effect while alleviating the concerns of patients and their families.
[0049] (3) Currently, the meningeal lymphatic phototherapy devices for the treatment of Alzheimer's disease on the market generally require therapists to manually adjust the treatment parameters, which is inconvenient to operate and has a low level of intelligence. The Glioflo device significantly improves the intelligence level of treatment by automatically adjusting the treatment parameters and optimizing the treatment effect based on the monitoring data.
[0050] (4) The Glioflo device can store the data collected during the treatment process in the device's hard disk. The later analysis of these data is crucial for therapists to accurately evaluate the treatment effect and adjust the treatment plan. This data storage capacity not only helps to improve the treatment effect but also provides valuable reference resources for therapists.
[0051] (5) Given that most Alzheimer's disease (AD) patients are elderly and some patients have limited mobility, while providing comprehensive treatment and monitoring, Glioflo cleverly integrates the device with a wheelchair, allowing users to easily adjust the positions of the infrared massager and the treatment helmet and fix them, effectively alleviating the discomfort suffered by patients when using the device. The design of the wheelchair also takes into account the mobility convenience of patients, aiming to provide the most efficient and comfortable treatment experience for patients. A small touch-screen computer is equipped at the rear of the wheelchair, which can perform real-time analysis and processing on various data collected during the treatment monitoring process and intuitively display the results to the caregiver for timely adjustment of the treatment plan.
[0052] It should be understood that various forms of the processes shown above can be used, with steps reordered, added, or deleted. For example, the steps described in the disclosure of the present invention can be executed in parallel, sequentially, or in a different order, as long as the desired results of the technical solution disclosed in the present invention can be achieved. No limitation is imposed herein.
[0053] The above specific embodiments do not constitute a limitation to the protection scope of the present invention. Those skilled in the art should understand that various modifications, combinations, sub-combinations, and substitutions can be made according to design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.
Claims
1. An integrated non-invasive AD treatment monitoring system, characterized in that: include: AD treatment helmet, physical therapy wheelchair and remote terminal; the AD treatment helmet and the physical therapy wheelchair are fixedly connected in a detachable manner; The AD treatment helmet includes a helmet body, and a photoacoustic stimulation unit, a transcranial magnetic therapy module and a Doppler ultrasound probe arranged on the helmet body; the photoacoustic stimulation unit includes a visual stimulation module and an auditory stimulation earphone, which are used to promote gamma neural oscillations in the brain; the visual stimulation module is arranged at the front end of the helmet body, and is used to induce hemodynamic response of the cerebral cortex to trigger neural activity; there are two auditory stimulation earphones, which are arranged on both sides of the helmet body respectively, corresponding to the positions of the ears; each auditory stimulation earphone is connected to a Doppler ultrasound probe; the transcranial magnetic therapy module includes six magnetic therapy heads, which are distributed at different positions of the helmet body, and the six magnetic therapy heads are respectively one top magnetic therapy head, one forehead magnetic therapy head, two temple magnetic therapy heads and two back brain magnetic therapy heads; the top magnetic therapy head corresponds to Baihe acupoint, the forehead magnetic therapy head corresponds to Shenting acupoint, the temple magnetic therapy head corresponds to Hanyan acupoint, and the back brain magnetic therapy head corresponds to Fengchi acupoint respectively; The physiotherapy wheelchair is equipped with a seat, a massager, a touch screen, a computer host, a cardiovascular monitoring component, and an adjustment button; the touch screen is installed on one side of the physiotherapy wheelchair, and the computer host is located under the backrest of the physiotherapy wheelchair; the touch screen is electrically controlled and connected to the computer host; the cardiovascular monitoring component and the adjustment button are arranged on the armrest of the physiotherapy wheelchair; there are two massagers, which correspond to the cervical and lumbar vertebrae respectively; the massagers are equipped with phototherapy lamp beads, which are used to promote human blood circulation and metabolism and assist in the treatment of Alzheimer's disease; the cardiovascular monitoring component monitors the patient's cardiovascular status in real time; the adjustment button adjusts the intensity of the phototherapy lamp beads; The remote terminal is connected to the computer host by wireless or wired connection, and is used to view or adjust treatment parameters, and freely control the switches of each module.
2. The integrated non-invasive AD treatment monitoring system according to claim 1, characterized in that: The front end of the helmet body is provided with a helmet tightening knob, and the rear end is provided with a buckle; the visual stimulation module is arranged below the helmet tightening knob; The visual stimulation module comprises glasses, both sides of which are provided with slide grooves; one end of the slide groove is fixedly connected to the glasses, and the other end is fixedly connected to the buckle; a transparent LED pulse light lens is provided on the glasses, and the transparent LED pulse light lens displays a radial checkerboard pattern flashing in reverse phase as a visual stimulation; the glasses are AR glasses or MR glasses.
3. The integrated non-invasive AD treatment monitoring system according to claim 2, characterized in that: The flashing frequency range of the glasses is 1 Hz to 20 Hz; An ultra-high-definition monitoring camera is provided above the transparent LED pulse light lens, and the ultra-high-definition monitoring camera is used to obtain the patient's eye information; The slide groove is arc-shaped; the glasses and the buckle form a circular headband through two slide grooves, and the circular headband corresponds to the horizontal plane of the brow bone of the head.
4. The integrated non-invasive AD treatment monitoring system according to claim 2, characterized in that: The helmet body is also provided with two elastic bands, and the two sides of the magnetic therapy head on the top of the head are respectively connected to the glasses of the visual stimulation module and the buckles at the rear of the helmet body through the elastic bands; the two elastic bands are each provided with a plurality of optical fiber interfaces; The elastic band is provided with a holder, which is connected to the transcranial magnetic therapy module and connected to the buckle at the rear of the helmet body; the helmet tightening knob adjusts the length and tightness of the elastic band, and is used to fix the AD treatment helmet on the patient's head; The optical fiber output interface on the therapy wheelchair is connected to the optical fiber interface through an optical fiber, and the near-infrared laser from the therapy wheelchair is transmitted to the optical fiber interface, and the laser is emitted through the optical fiber interface to irradiate the patient's meningeal lymphatic vessel site, thereby realizing the phototherapy function; The magnetic therapy vibration frequencies of the six magnetic therapy heads of the transcranial magnetic therapy module are all 2-10 Hz.
5. The integrated non-invasive AD treatment monitoring system according to claim 1, characterized in that: The front end of the helmet body is provided with a helmet tightening knob, and the rear end is provided with a buckle; the visual stimulation module is arranged below the helmet tightening knob; both sides of the visual stimulation module are provided with sliding grooves; There are two auditory stimulation earphones, which are respectively arranged on both sides of the helmet body, corresponding to the positions of the ears; the auditory stimulation earphones are slidably connected to the slide groove to ensure sliding on the slide groove; each auditory stimulation earphone is connected to a Doppler ultrasound probe, and the Doppler ultrasound probe is arranged above the auditory stimulation earphone.
6. The integrated non-invasive AD treatment monitoring system according to claim 5, characterized in that: A helmet card slot is provided below the auditory stimulation headset, and the helmet card slot is used to connect the physiotherapy wheelchair or other expansion equipment; A plurality of slide groove positioning convex edges are arranged in the slide groove, and after the relative positions of the two temple magnetic therapy heads, the two back-of-head magnetic therapy heads and the auditory stimulation earphones are adjusted, they can be kept stable by the slide groove positioning convex edges.
7. The integrated non-invasive AD treatment monitoring system according to claim 6, characterized in that: A helmet power supply interface is also provided at the lower rear side of the helmet body; the glasses, the transcranial magnetic therapy module, the auditory stimulation earphones and the Doppler ultrasound probe are connected to the helmet power supply interface via cables.
8. The integrated non-invasive AD treatment monitoring system according to claim 1, characterized in that: The physiotherapy wheelchair is also provided with a lifting and fixing rod, a lifting slide, and a translation slide; The lifting and fixing rod, the lifting and sliding groove and the translation sliding groove are arranged behind the backrest of the physiotherapy wheelchair; the touch screen is installed on one side of the physiotherapy wheelchair, and the computer host is arranged below the backrest of the physiotherapy wheelchair; the touch screen is electrically controlled and connected to the computer host; A helmet slot is provided below the auditory stimulation headset; the lifting and fixing rod is movably connected to the helmet slot in a detachable manner; the height position of the AD treatment helmet can be freely adjusted and fixed up and down by extending and retracting the lifting and fixing rod, and the horizontal relative position of the helmet slot and the lifting and fixing rod is moved to ensure that the AD treatment helmet can adapt to different users and reduce the neck pressure of the user; The upper and lower ends of the lifting slide are fixed on the frame of the physiotherapy wheelchair; two translation slides are provided, and the two translation slides are arranged in parallel on the lifting slide; Both massagers are provided with a massager frame, and the two massagers are fixed on the lifting slide through the massager frame; the massager frame enables the massagers to move freely up, down, left and right on the lifting slide to adjust the massage position; four pairs of lamp beads are provided on the massage empty slot in the center of the massager, and each pair of lamp beads includes 1 red light therapy lamp bead and 1 far-infrared light therapy lamp bead; the red light therapy lamp beads and the far-infrared light therapy lamp beads work together to promote blood circulation and metabolism throughout the body, and assist in the treatment of Alzheimer's disease.
9. The integrated non-invasive AD treatment monitoring system according to claim 8, characterized in that: The heart blood monitoring component includes a blood oxygen meter and a heart rate sensor; The oximeter uses a three-channel oximeter, which is located at the armrest of the therapy wheelchair. The heart rate sensor is located between the adjustment button and the oximeter. When the patient grasps the heart rate sensor to measure the heart rate, the wrist and arm are pressed on the oximeter to test the blood oxygen. The heart rate sensor and the oximeter monitor the patient's cardiovascular status in real time, so as to comprehensively judge the patient's physiological response during the treatment process and ensure the safety and effectiveness of the treatment. The adjustment button is used to adjust the intensity of the red light therapy lamp beads and far-infrared light therapy lamp beads; The red light therapy lamp beads have a wavelength of 630nm; the far-infrared light therapy lamp beads have a wavelength of 11μm.
10. The integrated non-invasive AD treatment monitoring system according to claim 8, characterized in that: The computer host is provided with a power supply access terminal, a power supply output interface, a device switch, and an optical fiber output interface; The power access terminal of the computer host is connected to the mains power supply to power the system; a power output interface is provided on one side of the computer host, and the power output interface is connected to the helmet power supply interface on the helmet body through a cable to provide power support to various components on the AD treatment helmet to ensure the normal operation of the equipment; the equipment switch is provided on one side of the computer host, and the equipment switch is used to control the power on and off of the entire system, so as to facilitate the patients and guardians to start and stop the equipment; The touch screen displays the treatment effect and provides adjustable treatment parameter options, and is used to analyze and process various data collected during the treatment monitoring process in real time, and present the results to the caregiver, so as to facilitate timely adjustment of the treatment plan.