Mosquito-repelling aromatherapy with trimethylsilyl modified aerogel as carrier

Abstract

The invention provides mosquito-repelling aromatherapy with trimethylsilyl modified aerogel as a carrier. According to the mosquito-repelling aromatherapy, trimethylsilyl modified aerogel serves as a carrier to adsorb mosquito-repelling components, the mosquito-repelling components comprise isoxazolidine compounds, the isoxazolidine compounds comprise one or more of compounds shown in the molecular structural formula I, the molecular structural formula II, the molecular structural formula III and the molecular structural formula IV, and in the molecular structural formula # imgabs0, R is Me, Et, i-Pr or n-Pr. The repelling rate of the mosquito-repelling aromatherapy is 100%, the mosquito-repelling effect is good, and A-level mosquito repelling is achieved; the cooling effect is also achieved; the carrier trimethylsilyl modified aerogel in the mosquito-repelling aromatherapy not only greatly prolongs the mosquito-repelling time of the mosquito-repelling component, has a slow-release effect on the release of the mosquito-repelling component, but also can protect the mosquito-repelling component from being easily oxidized and deteriorated, and can also adjust the saturation adsorption capacity of the mosquito-repelling aromatherapy by adjusting the density of the mosquito-repelling aromatherapy according to factors such as environmental humidity and pH which influence mosquitoes, so that the mosquito-repelling aromatherapy has a good mosquito-repelling effect. Further, the release of mosquito-repelling components is adjusted.

Description

Technical Field

[0001] The invention belongs to the technical field of mosquito repellent aromatherapy, and in particular relates to a mosquito repellent aromatherapy using trimethylsilyl modified aerogel as a carrier. Background Art

[0002] There are four types of effective mosquito repellent ingredients in mosquito repellent products on the market: DEET, chlorpyrifos, picaridin and citral essential oils.

[0003] The disadvantages of mosquito repellent aromatherapy mainly include the following aspects: slow and unstable volatilization rate. Some mosquito repellent aromatherapy sticks are made of a combination of plants, resins and wood. They emit fragrance naturally at room temperature, but the volatilization rate is slow and the effect is unstable. They are greatly affected by changes in temperature and humidity. Especially in environments with large changes in temperature and humidity, their volatility fluctuates greatly, resulting in poor mosquito repellent effect; the ingredients may be toxic or allergic. Although some mosquito repellent products use natural plant essential oils as the main ingredients, these essential oils may also be toxic or cause allergic reactions. For example, although camphor has a significant insect repellent effect, it is irritating and not suitable for children; the mosquito repellent effect is limited. The mosquito repellent effect of some natural plant essential oils is not long-lasting, easy to volatilize, and cannot provide long-term protection. In addition, some pure plant mosquito repellent products do not achieve effective mosquito repellent effects and have a strong odor. Environmental pollution issues. Some chemically synthesized mosquito repellent ingredients, such as DEET, may pollute the environment and have toxic side effects on the human body, such as neurological symptoms and skin damage, after long-term use. Indoor air pollution, mosquito repellent products such as mosquito coils will release harmful substances during the combustion process, such as PM2.5 particles, TVOC and CO. These substances are harmful to human health. Long-term exposure may cause cancer and damage the respiratory system.

[0004] To avoid using harmful chemicals, try to avoid using mosquito repellent products containing chemical ingredients such as DEET, chlorpyrifos, and picaridin, because these ingredients may have a negative impact on the environment. For example, DEET can irritate the skin in some cases. Moreover, the first three (DEET, chlorpyrifos, and picaridin) are all pesticides and have certain toxicity. The fourth type of citral essential oils, citral, citronellal, and geraniol, are all naturally present in mosquito repellents. The flavors and fragrances in citral essential oils have the characteristics of soothing the body and mind and covering up odors, especially sweat odors. Using aroma to repel insects is not only convenient and environmentally friendly, but also can reduce the use of pesticides, thus having a profound impact on the use of pesticides in agriculture and other related fields. In addition, aroma mosquito repellent products do not produce immune responses to insect species like chemical pesticides, avoiding the problems of bioaccumulation and biomagnification. In terms of safety, they are generally considered non-toxic to humans and pets.

[0005] However, citral essential oils rely on their aroma to repel mosquitoes, and the mosquito repellent effect is shorter than 2 hours, requiring repeated application or spraying; the aldehydes are easily oxidized and deteriorate, and after deterioration, they lose their mosquito repellent effect; the release rate of citral essential oils is difficult to control, and citral essential oils do not respond to factors that affect mosquitoes, such as environmental humidity and pH, and their release is uncontrollable. Summary of the invention

[0006] In order to solve the problems in the prior art, the present invention provides a mosquito repellent aromatherapy using trimethylsilyl modified aerogel as a carrier.

[0007] The specific technical solutions of the present invention are as follows:

[0008] The mosquito repellent aromatherapy using trimethylsilyl modified aerogel as a carrier provided by the present invention is characterized in that the mosquito repellent aromatherapy uses trimethylsilyl modified aerogel as a carrier to adsorb mosquito repellent components, wherein the mosquito repellent components include isoxazolidine compounds, and the isoxazolidine compounds include one or more of the compounds represented by the following molecular structural formulas I, II, III and IV. In the formula, R is Me, Et, i-Pr or n-Pr (R is methyl, ethyl, n-propyl or isopropyl).

[0009] The mosquito repellent incense with trimethylsilyl modified aerogel as a carrier provided by the present invention also has such technical characteristics, wherein the preparation method of trimethylsilyl modified aerogel comprises the following steps: step S1, mixing a silicon source, a solvent 1 and water for hydrolysis reaction to obtain a hydrolysis solution; step S2, adjusting the pH to make the hydrolysis solution gel, heat-drying and curing the gel, and obtaining a gel after heat-drying and curing; step S3, mixing the solvent 2 and the modifier evenly to obtain a modified liquid, immersing the gel after heat-drying and curing in the modified liquid, heat-drying and curing again, and obtaining a gel after heat-drying and curing again; step S4, supercritical CO 2 The gel is extracted and heat-dried and cured again to obtain trimethylsilyl-modified aerogel.

[0010] The mosquito repellent incense with trimethylsilyl modified aerogel as a carrier provided by the present invention also has the following technical features: wherein, in step S1, the silicon source is methyl orthosilicate or ethyl orthosilicate; the solvent 1 is methanol or ethanol; the temperature of the hydrolysis reaction is 50-70°C, the pH is 1.0-3.0, and the time is 6-10h; the mass ratio of the silicon source, the solvent 1 and water is 1:(4-6):(0.1-0.3).

[0011] The mosquito repellent aromatherapy with trimethylsilyl modified aerogel as a carrier provided by the present invention also has the following technical features: wherein, in step S2, the pH is adjusted to 7.5-8.5; the temperature of the heat drying curing is 60-80° C., and the time is 6-12 hours.

[0012] The mosquito repellent incense with trimethylsilyl modified aerogel as a carrier provided by the present invention also has the following technical features: in step S3, the solvent 2 is one or more of acetone, ethanol, n-hexane and n-heptane; the modifier is hexamethyldisilazane, trimethylchlorosilane or triphenylchlorosilane; the mass ratio of the solvent 2 to the modifier is (8-20):1; the temperature of the second heat drying curing is 60-80°C and the time is 6-12h.

[0013] The mosquito repellent aromatherapy using trimethylsilyl modified aerogel as a carrier provided by the present invention also has the following technical features: wherein the supercritical CO 2 The extraction stage temperature is 50-70℃, the extraction stage pressure is 10-15MPa, the separation stage temperature is 35-60℃, the separation stage pressure is 4.5-5.5MPa, and the supercritical CO 2 The extraction time is 6-12h.

[0014] The mosquito repellent aromatherapy with trimethylsilyl modified aerogel as carrier provided by the present invention also has the following technical features: the density of the trimethylsilyl modified aerogel is 0.050-0.165 g / cm 3 .

[0015] The mosquito repellent incense with trimethylsilyl modified aerogel as a carrier provided by the present invention also has the following technical characteristics, wherein the adsorption is saturated adsorption.

[0016] The mosquito repellent incense with trimethylsilyl modified aerogel as a carrier provided by the present invention also has the following technical features: the trimethylsilyl modified aerogel is in the form of blocks, particles or powders.

[0017] Functions and Effects of the Invention

[0018] The invention combines a novel effective mosquito repellent component isoxazolidine compound with aerogel to provide a mosquito repellent aromatherapy using trimethylsilyl modified aerogel as a carrier.

[0019] Compared with the prior art, the technical advantages of the present invention are as follows:

[0020] (1) The mosquito repellent aromatherapy provided by the present invention has a repellency rate of 100%, and has a very good mosquito repellent effect, reaching Class A mosquito repellent.

[0021] (2) The mosquito repellent aromatherapy provided by the present invention uses isoxazolidine compounds as effective mosquito repellent ingredients for the first time, which not only has a mosquito repellent effect but also has a cooling effect.

[0022] (3) The mosquito repellent aromatherapy provided by the present invention has three major advantages in using trimethylsilyl modified aerogel as a carrier: 1. It greatly prolongs the mosquito repellent effect of the mosquito repellent component and has a slow-release effect on the release of the mosquito repellent component; 2. It protects the mosquito repellent component from being easily oxidized and deteriorated; 3. It can adjust the saturated adsorption amount (its saturated adsorption capacity can reach 5-20 times the weight of the aerogel) by adjusting the density of the trimethylsilyl modified aerogel according to factors affecting mosquitoes such as environmental humidity and pH, thereby adjusting the release of the mosquito repellent component and achieving controllable release. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a corresponding relationship diagram between the density of the trimethylsilyl modified aerogel prepared in Example 1 and the saturated adsorption amount of citral.

[0024] Figure 2 This is a corresponding relationship diagram between the density of the trimethylsilyl modified aerogel prepared in Example 1 and the saturated adsorption amount of citronellal.

[0025] Figure 3 This is a corresponding relationship diagram between the density of the trimethylsilyl-modified aerogel prepared in Example 1 and the saturated adsorption amount of cinnamaldehyde.

[0026] Figure 4 1 is a graph showing the corresponding relationship between the density of the trimethylsilyl modified aerogel prepared in Example 1 and the saturated adsorption amount of 1-isopropyl-3,3,5,7-tetramethyloctahydrobenzo[c]isoxazole.

[0027] Figure 5 The figure is a corresponding relationship diagram between the density of the trimethylsilyl modified aerogel prepared in Example 1 and the saturated adsorption amount of a mixture of 1-isopropyl-3,3,6-trimethyloctahydrobenzo[c]isoxazole and 1,3,3,6-tetramethyloctahydrobenzo[c]isoxazole in a mass ratio of 1:1. DETAILED DESCRIPTION

[0028] The terms used in the present invention, unless otherwise specified, generally have the meanings that are commonly understood by those of ordinary skill in the art.

[0029] In the following examples, various processes and methods not described in detail are conventional methods well known in the art.

[0030] The reagents used in the following examples were purchased from common commercial sources, and the experimental operations and experimental conditions not specified were referred to the conventional operations and conventional conditions in the art.

[0031] The specific implementation of the present invention is described below with reference to embodiments.

[0032] <Example 1>

[0033] This embodiment provides a method for preparing trimethylsilyl modified aerogel, and the preparation steps are as follows:

[0034] Step S1, mixing the silicon source, solvent 1 and water for hydrolysis reaction to obtain a hydrolysis solution. The specific process is:

[0035] Tetraethyl orthosilicate, ethanol and water were mixed in a mass ratio of 1:5:0.2, and hydrolysis reaction was carried out at 60° C. and pH 2.0 for 8 hours to obtain a hydrolysis solution.

[0036] Step S2, adjusting the pH to make the hydrolyzed solution gel, and heat-drying and curing the gel to obtain a heat-drying and curing gel.

[0037] The specific process is:

[0038] The pH of the hydrolyzed solution was adjusted to 7.6, and the solution was injected into a mold to gel. After gelation, the solution was placed in a 70° C. oven for curing for 12 hours to obtain a gel block after heat curing.

[0039] Step S3, the solvent 2 and the modifier are mixed evenly to obtain a modified liquid, the gel after heat curing is immersed in the modified liquid, and heat-cured again to obtain a gel after heat curing again. The specific process is:

[0040] The solvent 2 (a mixture of acetone and ethanol, with a mixing mass ratio of 2:1) and the modifier hexamethyldisilazane are uniformly mixed in a mass ratio of 10:1 to obtain a modified solution, and the gel block after heat curing obtained in step S2 is immersed in the modified solution and placed in an oven at 70°C for curing for 12 hours to obtain a gel block after heat curing again.

[0041] Step S4, supercritical CO 2 The gel is extracted and heat-dried again to obtain trimethylsilyl modified aerogel. The specific process is:

[0042] Take out the gel block after heat drying and put it into supercritical CO 2 The extraction reactor was set at an extraction stage temperature of 55°C, an extraction stage pressure of 10 MPa, a separation stage temperature of 45°C, a separation stage pressure of 5.5 MPa, and the extraction was performed for 6 hours to obtain trimethylsilyl-modified aerogel blocks.

[0043] In this embodiment, the density of the trimethylsilyl modified aerogel is adjusted by adjusting the mass ratio of the silicon source, solvent 1 and water in step S1; ethylene glycol is added in step S1 to adjust the pore size distribution of the trimethylsilyl modified aerogel, and the mass of ethylene glycol is 0.5, 1, 1.5, 2, 2.5, 1.25, and 2.25 times that of the silicon source. Through adjustment, the density range of this embodiment is 0.062-0.153 g / cm 3 Trimethylsilyl-modified aerogel blocks.

[0044] The trimethylsilyl modified aerogel block prepared above was subjected to an adsorption test. The test method is: use a 30mL glass bottle as a container to test the saturated adsorption capacity of trimethylsilyl modified aerogel for essential oil. Specifically, an excess of essential oil is dripped onto about 0.3-0.5g of accurately weighed trimethylsilyl modified aerogel (accurate to one ten-thousandth of a gram), and the adsorption is carried out for 24 hours. The residual essential oil droplets that cannot be adsorbed are removed with a pipette and a capillary, and the weight of the essential oil adsorbed on the trimethylsilyl modified aerogel is accurately weighed (accurate to one ten-thousandth of a gram), and the saturated adsorption capacity is calculated. The essential oil used in this test is citral. The saturated adsorption capacity of trimethylsilyl modified aerogel is calculated as: saturated adsorption capacity = saturated adsorption essential oil mass / 100g aerogel mass.

[0045] Furthermore, this example studies the effect of trimethylsilyl modified aerogels of different densities on the saturated adsorption of citral. Trimethylsilyl modified aerogel blocks of different densities are taken for adsorption test according to the above test method to obtain the corresponding relationship between the density of trimethylsilyl modified aerogel and its saturated adsorption amount, which is listed in Table 1 and shown in Table 2. Figure 1 shown.

[0046] Table 1

[0047] Aerogel A B C D E F G Ethylene glycol:ethyl orthosilicate 0.5 1 1.5 2 2.5 1.25 2.25 <![CDATA[Density (g / cm 3 )]]> 0.153 0.141 0.092 0.062 0.135 0.122 0.108 Saturated adsorption capacity (g / 100g aerogel) 613 619 994 1125 697 881 968

[0048] From Table 1, Figure 1 It can be seen that the density of trimethylsilyl-modified aerogel is inversely proportional to its saturated adsorption capacity.

[0049] Furthermore, this example studies the effect of trimethylsilyl modified aerogels of different densities on the saturated adsorption of citronellal. Trimethylsilyl modified aerogel blocks of different densities are taken for adsorption test according to the above test method to obtain the corresponding relationship between the density of trimethylsilyl modified aerogel and its saturated adsorption amount, which is listed in Table 2 and shown in Table 2. Figure 2 shown.

[0050] Table 2

[0051] Aerogel F G D Ethylene glycol:ethyl orthosilicate 1.25 2.25 2 <![CDATA[Density (g / cm 3 )]]> 0.122 0.108 0.062 Saturated adsorption capacity (g / 100g aerogel) 923 1074 1462

[0052] From Table 2, Figure 2 It can be seen that the density of trimethylsilyl-modified aerogel is inversely proportional to its saturated adsorption capacity.

[0053] Furthermore, this example studies the effect of trimethylsilyl modified aerogels of different densities on the saturated adsorption of cinnamaldehyde. Trimethylsilyl modified aerogel blocks of different densities are taken for adsorption test according to the above test method to obtain the corresponding relationship between the density of trimethylsilyl modified aerogel and its saturated adsorption amount, which is listed in Table 3 and shown in Table 4. Figure 3 shown.

[0054] Table 3

[0055] Aerogel F G D Ethylene glycol:ethyl orthosilicate 1.25 2.25 2 <![CDATA[Density (g / cm 3 )]]> 0.122 0.108 0.062 Saturated adsorption capacity (g / 100g aerogel) 1014 1359 2359

[0056] From Table 3, Figure 3 It can be seen that the density of trimethylsilyl-modified aerogel is inversely proportional to its saturated adsorption capacity.

[0057] Furthermore, this example studies the effect of trimethylsilyl modified aerogels of different densities on the saturated adsorption of 1-isopropyl-3,3,5,7-tetramethyloctahydrobenzo[c]isoxazole. Trimethylsilyl modified aerogel blocks of different densities are taken for adsorption test according to the above test method to obtain the corresponding relationship between the density of trimethylsilyl modified aerogel and its saturated adsorption amount, which is listed in Table 4 and shown in Table 5. Figure 4 shown.

[0058] Table 4

[0059] Aerogel A F G D Ethylene glycol:ethyl orthosilicate 0.5 1.25 2.25 2 <![CDATA[Density (g / cm 3 )]]> 0.153 0.122 0.108 0.062 Saturated adsorption capacity (g / 100g aerogel) 635 999 1010 1428

[0060] From Table 4, Figure 4 It can be seen that the density of trimethylsilyl-modified aerogel is inversely proportional to its saturated adsorption capacity.

[0061] Further, this example studies the effect of trimethylsilyl modified aerogels of different densities on the saturated adsorption capacity of a mixture of 1-isopropyl-3,3,6-trimethyloctahydrobenzo[c]isoxazole and 1,3,3,6-tetramethyloctahydrobenzo[c]isoxazole in a mass ratio of 1:1. Trimethylsilyl modified aerogel blocks of different densities were taken for adsorption test according to the above test method, and the corresponding relationship between the density of the trimethylsilyl modified aerogel and its saturated adsorption capacity was obtained, which is listed in Table 5 and shown in Table 5. Figure 5 shown.

[0062] Table 5

[0063] Aerogel A F G D Ethylene glycol:ethyl orthosilicate 0.5 1.25 2.25 2 <![CDATA[Density (g / cm 3 )]]> 0.153 0.122 0.108 0.062 Saturated adsorption capacity (g / 100g aerogel) 583 973 1060 1322

[0064] From Table 5, Figure 5 It can be seen that the density of trimethylsilyl-modified aerogel is inversely proportional to its saturated adsorption capacity.

[0065] The present invention can adjust the density of trimethylsilyl modified aerogel to 0.050-0.165g / cm 3 , so that its saturated adsorption capacity reaches 5-20 times the weight of aerogel.

[0066] Therefore, for mosquito repellent aromatherapy using trimethylsilyl modified aerogel as a carrier, when the mosquito repellent effect of the mosquito repellent component is too weak and the aerogel adsorption capacity needs to be enhanced, the aerogel density can be reduced to increase its saturated adsorption capacity and adsorb more mosquito repellent components to achieve the purpose of mosquito repelling. When the mosquito repellent component is expensive and the aerogel adsorption capacity needs to be weakened, the aerogel density can be increased to reduce its saturated adsorption capacity and adsorb the mosquito repellent component to achieve the optimal ratio.

[0067] In addition, when factors affecting mosquitoes such as environmental humidity and pH change, the mosquito repellent aromatherapy provided by the present invention using trimethylsilyl modified aerogel as a carrier can adjust the saturated adsorption amount of the aerogel by adjusting its density, thereby adjusting the release of the mosquito repellent ingredients to achieve the purpose of controllable release.

[0068] <Example 2>

[0069] The density of the sample prepared in Example 1 is 0.153 g / cm 3 The trimethylsilyl modified aerogel block is used as a carrier to saturate the mosquito repellent component 1-isopropyl-3,3,5,7-tetramethyloctahydrobenzo[c]isoxazole, the molecular structure of which is: A mosquito repellent aromatherapy with trimethylsilyl modified aerogel as a carrier was obtained (the saturated adsorption capacity was 635 g / 100 g).

[0070] <Example 3>

[0071] The density of the sample prepared in Example 1 is 0.153 g / cm 3 The trimethylsilyl modified aerogel block was used as a carrier to saturate the mosquito repellent ingredients 1-isopropyl-3,3,6-trimethyl octahydrobenzo[c]isoxazole and 1,3,3,6-tetramethyl octahydrobenzo[c]isoxazole in a mass ratio of 1:1 to obtain a mosquito repellent aromatherapy with trimethylsilyl modified aerogel as a carrier (saturated adsorption amount is 583g / 100g). The molecular structure of 1-isopropyl-3,3,6-trimethyl octahydrobenzo[c]isoxazole is: The molecular structure of 1,3,3,6-tetramethyloctahydrobenzo[c]isoxazole is:

[0072] <Comparative Example>

[0073] The density of the sample prepared in Example 1 is 0.153 g / cm 3 The trimethylsilyl-modified aerogel block was used as a carrier to saturately adsorb a mixture of mosquito repellent ingredients, citral, citronellal and cinnamaldehyde, mixed in a mass ratio of 1:1:1, to obtain a mosquito repellent aromatherapy with the trimethylsilyl-modified aerogel as a carrier (saturated adsorption capacity is 602g / 100g).

[0074] <Test example>

[0075] 1. The mosquito repellent incense obtained in the above Examples 2, 3 and the comparative example was placed in a non-sealed environment for 24 hours and then tested for mosquito repellent effect (tested by Beijing Qingxi Technology Research Institute). The test method is as follows: According to GB / T30126-2013 test, each test volunteer is two men and two women, 0.1g of mosquito repellent incense is spread on the volunteer's arm (5cm×5cm), 300 active Aedes albopictus (female adults 4-7 days after emergence) are used in each test, the mosquito cage volume is 40cm×40cm×40cm, the temperature is 26±1℃, and the relative humidity is 65±10%.

[0076] The test results show that the mosquito repellent aromatherapy obtained in Examples 2 and 3 and the comparative example has a repellent rate of 100%, and the mosquito repellent effect is very good.

[0077] 2. This test example also placed a mixture of 1-isopropyl-3,3,5,7-tetramethyloctahydrobenzo[c]isoxazole, 1-isopropyl-3,3,6-trimethyloctahydrobenzo[c]isoxazole and 1,3,3,6-tetramethyloctahydrobenzo[c]isoxazole in a mass ratio of 1:1, and a mixture of citral, citronellal and cinnamaldehyde in a mass ratio of 1:1:1 in a non-sealed environment for 24 hours to test the mosquito repellent effect (tested by Beijing Qingxi Technology Research Institute). The test method is the same as above.

[0078] The test results are: after 24 hours, all three mosquito repellent ingredients are completely volatilized and lose their mosquito repellent effect.

[0079] By comparing the above two test results, it can be seen that the carrier trimethylsilyl-modified aerogel greatly prolongs the repellent effect of the mosquito repellent ingredient and has a sustained-release effect on the release of the mosquito repellent ingredient.

[0080] 3. This test example also used trimethylsilyl modified aerogel as a carrier (density 0.153 g / cm 3 ) Saturated adsorption of 2-methylundecane fragrance (saturated adsorption capacity is 626g / 100g) and aroma test (smell) of 2-methylundecane after being placed at 25-30℃ with air flow for 24h.

[0081] Test results: After 24 hours, 2-methyl undecanedialdehyde without trimethylsilyl modified aerogel showed an unpleasant grease aroma, which was oxidized to 2-methyl undecanediol with a lower threshold. The aromatherapy with trimethylsilyl modified aerogel as a carrier saturated with 2-methyl undecanediol still had a partial aldehyde fragrance and a fresh fragrance, which could be maintained for 1 week. After one week, a very weak grease aroma could be smelled.

[0082] This test example also used trimethylsilyl modified aerogel as the carrier (density 0.108 g / cm 3) Aromatherapy with saturated adsorption of cinnamaldehyde (saturated adsorption capacity is 1359g / 100g) and aroma test (smell) of cinnamaldehyde after being placed at 25-30℃ with air flow for a certain period of time.

[0083] Test results: 0.24g of cinnamaldehyde will volatilize 80wt% on the 6th day, and the remaining 20wt% will all become solid cinnamic acid. However, 0.24g of aromatherapy only desorbs 3wt% of cinnamaldehyde in 10 days, and the smell remains unchanged.

[0084] This indicates that trimethylsilyl-modified aerogel can protect mosquito repellent ingredients from oxidation and deterioration.

[0085] The above is a detailed description of the embodiments, which is convenient for those skilled in the art to correctly understand and use the present invention. Any improvements or modifications to the technical solutions obtained by those skilled in the art based on the present invention on the basis of the prior art, without innovative work, only through analysis, analogy or limited enumeration, etc., should be within the scope of protection determined by the claims.

Claims

1. A mosquito repellent aromatherapy using trimethylsilyl modified aerogel as a carrier, characterized in that: The mosquito repellent aromatherapy uses trimethylsilyl modified aerogel as a carrier to absorb mosquito repellent ingredients. Wherein, the mosquito repellent component includes isoxazolidine compounds, The isoxazolidine compounds include one or more of the compounds represented by the following molecular structural formulas Ⅰ, Ⅱ, Ⅲ and Ⅳ, Wherein, R is Me, Et, i-Pr or n-Pr.

2. The mosquito repellent incense using trimethylsilyl modified aerogel as a carrier according to claim 1, It is characterized in that The preparation method of the trimethylsilyl modified aerogel comprises the following steps: Step S1, mixing a silicon source, a solvent 1 and water to perform a hydrolysis reaction to obtain a hydrolysis solution; Step S2, adjusting the pH to make the hydrolysis solution gel, and heat-drying and curing the gel to obtain a heat-drying and curing gel; Step S3, uniformly mixing the solvent 2 and the modifier to obtain a modified liquid, immersing the heat-cured gel in the modified liquid, and heat-curing again to obtain a heat-cured gel; Step S4, extracting the gel after heat drying and curing again with supercritical CO2 to obtain the trimethylsilyl modified aerogel.

3. The mosquito repellent incense with trimethylsilyl modified aerogel as carrier according to claim 2, characterized in that: in, The silicon source in step S1 is methyl orthosilicate or ethyl orthosilicate; The solvent 1 is methanol or ethanol; The hydrolysis reaction temperature is 50-70°C, the pH is 1.0-3.0, and the time is 6-10h; The mass ratio of the silicon source, the solvent 1 and the water is 1:(4-6):(0.1-0.3).

4. The mosquito repellent incense using trimethylsilyl modified aerogel as a carrier according to claim 2, characterized in that: in, The step S2 wherein the pH is adjusted to 7.5-8.5; The temperature of the heat baking curing is 60-80°C and the time is 6-12h.

5. The mosquito repellent incense using trimethylsilyl modified aerogel as a carrier according to claim 2, characterized in that: in, In step S3, the solvent 2 is one or more of acetone, ethanol, n-hexane and n-heptane; The modifier is hexamethyldisilazane, trimethylchlorosilane or triphenylchlorosilane; The mass ratio of the solvent 2 to the modifier is (8-20):1; The temperature of the second heat drying and curing is 60-80°C and the time is 6-12h.

6. The mosquito repellent aromatherapy using trimethylsilyl modified aerogel as a carrier according to claim 2, characterized in that: in, The extraction stage temperature of the supercritical CO2 extraction in step S4 is 50-70°C, the extraction stage pressure is 10-15MPa, the separation stage temperature is 35-60°C, the separation stage pressure is 4.5-5.5MPa, and the supercritical CO2 extraction time is 6-12h.

7. The mosquito repellent incense using trimethylsilyl modified aerogel as a carrier according to claim 1, characterized in that: in, The density of the trimethylsilyl modified aerogel is 0.050-0.165 g / cm 3 .

8. The mosquito repellent incense using trimethylsilyl modified aerogel as a carrier according to claim 1, characterized in that: in, The adsorption is saturated adsorption.

9. The mosquito repellent incense using trimethylsilyl modified aerogel as a carrier according to claim 1, characterized in that: in, The trimethylsilyl modified aerogel is in the form of blocks, particles or powders.

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