Optical fiber device for phototherapy and varicosity minimally invasive phototherapy device

Abstract

The invention discloses an optical fiber device for phototherapy and a varicosity minimally invasive phototherapy device, and relates to the technical field of medical instruments, the optical fiber device for phototherapy comprises an optical fiber, a photo-thermal photosensitive layer and a temperature sensor; one end of the optical fiber serves as a probe to extend into a human body, and the other end is used for inputting treatment light; a photo-thermal photosensitizer is coated outside the probe to form a photo-thermal photosensitive layer; and the temperature sensor is arranged in the probe. The operation safety can be improved, the operation efficiency is improved, and operation and control are convenient.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to an optical fiber device for phototherapy and a minimally invasive phototherapy device for varicose veins. Background Art

[0002] Varicose veins are a common vascular disease that mainly occurs in the superficial venous system of the lower limbs. It is caused by abnormal blood circulation, which blocks the return of blood in the veins, leading to venous expansion, varicose veins and blood congestion. Early varicose veins will cause symptoms of soreness, discomfort and surface phlebitis, and worsening may also lead to serious complications such as bleeding, skin ulcers and thrombosis. Therefore, timely intervention and medical treatment of varicose veins can help control the progression of the disease, alleviate symptoms, prevent and treat complications, and improve the quality of life of patients.

[0003] For more severe varicose veins, surgical interventions such as vascular resection, cauterization, and laser treatment are necessary medical treatments. Traditional open surgery is traumatic and has a long recovery period, and today's medical strategies tend to use more precise and personalized minimally invasive interventions. However, the laser and radiofrequency ablation therapies currently used for minimally invasive interventions have problems such as high operating power, difficulty in controlling the in situ ablation temperature, and uneven heat absorption by tissues, which can cause safety risks such as tissue edema, burns, and pigment changes. Summary of the invention

[0004] The purpose of the present invention is to provide an optical fiber device for phototherapy and a minimally invasive phototherapy device for varicose veins, so as to solve the problems existing in the above-mentioned prior art, improve safety, increase efficiency and facilitate operation.

[0005] To achieve the above object, the present invention provides the following solutions:

[0006] The present invention provides an optical fiber device for phototherapy, comprising: an optical fiber, a photothermal photosensitive layer and a temperature sensor; one end of the optical fiber is used as a probe for extending into the human body, and the other end is used for inputting therapeutic light; the outside of the probe is coated with a photothermal photosensitizer to form a photothermal photosensitive layer; the temperature sensor is arranged in the probe.

[0007] Preferably, the probe is coated with a tracer coating.

[0008] Preferably, the photothermal and photosensitive layer is ring-shaped.

[0009] Preferably, the tracer coating is ring-shaped.

[0010] Preferably, the probe is a truncated cone structure, and the small end of the probe is the distal end.

[0011] Preferably, the temperature sensor is arranged at a position in the probe corresponding to the photothermal photosensitive layer.

[0012] Preferably, the temperature sensor is an optical fiber temperature sensor.

[0013] Preferably, the diameter of the optical fiber is greater than 400 microns.

[0014] The present invention also provides a minimally invasive phototherapy device for varicose veins, comprising a therapeutic light source module and the optical fiber device for phototherapy as described above, wherein the therapeutic light source module can input therapeutic light to an end of the optical fiber away from the probe.

[0015] Preferably, it further comprises an optical fiber temperature sensor addressing module, the temperature sensor in the optical fiber device for phototherapy is an optical fiber temperature sensor, and the optical fiber temperature sensor addressing module can detect the reflected signal returned by the optical fiber temperature sensor.

[0016] Compared with the prior art, the present invention has achieved the following technical effects:

[0017] First, the optical fiber device for phototherapy provided by the present invention can achieve a temperature for blood vessel closure at an input power as low as 1W or less, thus achieving the purpose of low-power treatment with high safety.

[0018] Second, the photothermal photosensitive layer can generate heat more evenly in the target area, avoiding damage to human tissue and improving safety.

[0019] Third, the temperature during the treatment process is monitored in real time to avoid complications caused by improper light power or temperature.

[0020] In summary, the present invention has the advantages of easy control, fast response, less trauma, high efficiency and high safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 A schematic diagram of the structure of an optical fiber device for phototherapy provided in Embodiment 1 of the present invention;

[0023] Figure 2 This is a schematic diagram of the application of the optical fiber device for phototherapy provided in the first embodiment of the present invention;

[0024] Figure 3 A schematic diagram of the structure of the optical fiber device for phototherapy provided by the first embodiment of the present invention when in use;

[0025] In the figure: 1-optical fiber; 2-photothermal photosensitive layer; 3-tracing coating; 4-temperature sensor; 5-input light; 6-temperature sensing return signal; 7-vascular intervention catheter; 8-target area; 9-blood vessel; 10-human body; 11-probe. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0027] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the present invention is further described in detail below with reference to the accompanying drawings and specific embodiments.

[0028] Combine the following Figures 1 to 3 , describing an embodiment of the present invention.

[0029] Embodiment 1

[0030] An embodiment of the present invention provides an optical fiber device for phototherapy, which can be used for minimally invasive phototherapy of varicose veins, including: an optical fiber 1, a photothermal photosensitive layer 2 and a temperature sensor 4; one end of the optical fiber 1 is used as a probe 11 for extending into the human body, and the other end is used to input therapeutic light; the outside of the probe 11 is coated with a photothermal photosensitizer to form the photothermal photosensitive layer 2; the temperature sensor 4 is arranged in the probe 11.

[0031] During use, the probe 11 enters the blood vessel through a minimally invasive interventional catheter and reaches the area to be treated. The photothermal photosensitive layer 2 is used to receive therapeutic light. The photothermal effect of the photothermal photosensitive layer 2 is used to make the probe 11 generate local high temperature to close the blood vessel, thereby achieving varicose vein treatment.

[0032] In addition, there is a phototherapy scheme in the related art that sets the photothermal photosensitizer inside the front end of the optical fiber. However, when this scheme is implemented, the photothermal photosensitizer needs to be drawn together with the optical fiber, which has poor flexibility. The embodiment of the present invention coats the outside of the optical fiber, and the shape and coating thickness of the photothermal photosensitizer can be flexibly designed. In addition, the photothermal effect is closer to the target, the transmission effect is better, and the input power is further reduced.

[0033] The embodiments of the present invention have the following effects:

[0034] First, the optical fiber device for phototherapy provided by the present invention can achieve a temperature for blood vessel closure at an input power as low as 1W or less, thus achieving the purpose of low-power treatment with high safety.

[0035] Second, the photothermal photosensitive layer 2 can generate heat more evenly in the target area, avoiding damage to human tissue and improving safety.

[0036] Third, the temperature during the treatment process is monitored in real time to avoid complications caused by improper light power or temperature, ensuring the efficiency of the treatment, instant feedback of information, and safety.

[0037] In summary, the embodiments of the present invention have the advantages of easy control, fast response, small trauma, high efficiency and high safety.

[0038] In some embodiments, the probe 11 is further coated with a tracer coating 3. The tracer coating 3 may be a metal coating, and the metal coating may be selected from metals such as aluminum, tungsten, iron, gold, silver, copper, and alloys thereof.

[0039] The embodiment of the present invention realizes visualization of the probe 11 in the body, and can be specifically applied to the image navigation environment of angiography X-ray machine. When magnetic resonance imaging navigation is adopted, no coating is required, or other coatings that resist electromagnetic interference may be provided.

[0040] It is understandable that the present invention can select different coating categories or choose whether to set the coating according to different treatment environments and medical imaging technologies.

[0041] In some embodiments, the photothermal photosensitive layer 2 is ring-shaped.

[0042] This embodiment expands the range of the heating area, thereby improving the treatment effect and facilitating control.

[0043] In some embodiments, the photothermal photosensitizer is a photothermal material such as rare earth ions, bismuth ions, cobalt ions, or graphene, graphene oxide, carbon nanotubes, Mxene (two-dimensional layered nanomaterials), black phosphorus, or purple phosphorus.

[0044] In some embodiments, the photothermal photosensitizer is fixed to the outer surface of the body by hydrogen bonding, chemical bonding and electrostatic adsorption, which reduces the risk of the fiber optic photosensitizer remaining in the blood vessel and improves the treatment efficiency and safety.

[0045] In some embodiments, the tracer coating 3 is ring-shaped.

[0046] In some embodiments, the probe 11 is a truncated cone structure, the small end of the probe 11 is the distal end, and the truncated cone structure is obtained by etching or flame tapering the cylindrical cladding structure of the optical fiber 1 .

[0047] The truncated cone-shaped structure of the probe 11 in this embodiment facilitates the end of the probe 11 to extend into a narrow area for thermal radiation therapy.

[0048] In some embodiments, a temperature sensor 4 is disposed at a position in the probe 11 corresponding to the photothermal photosensitive layer 2 .

[0049] This embodiment improves the accuracy of temperature detection.

[0050] In some embodiments, the temperature sensor 4 is a fiber optic temperature sensor, which is a fiber grating or fiber mode interferometer sensing structure.

[0051] In some embodiments, the diameter of the optical fiber 1 is greater than 400 microns.

[0052] In some embodiments, the core diameter of the optical fiber 1 is 30-1000 microns, and the radial thickness of the cladding structure is 5-200 microns.

[0053] In some embodiments, the length of the probe 11 is 3-2000 mm.

[0054] Embodiment 2

[0055] An embodiment of the present invention provides a minimally invasive phototherapy device for varicose veins, comprising a therapeutic light source module and the phototherapy optical fiber device described in Embodiment 1. The therapeutic light source module can input therapeutic light to an end of the optical fiber away from the probe 11.

[0056] An optical interface is provided at the proximal end of the optical fiber 1, and the optical interface is used to transmit therapeutic light and temperature response signals to the optical fiber 1. The therapeutic light source module transmits the therapeutic light to the probe 11 through the optical interface to stimulate the photothermal photosensitive layer 2 to generate heat energy in the target area through the photothermal effect.

[0057] In some embodiments, the present invention further includes an optical fiber temperature sensor addressing module, the temperature sensor in the optical fiber device for phototherapy is an optical fiber temperature sensor, and the optical fiber temperature sensor addressing module can detect the reflected signal returned by the optical fiber temperature sensor to achieve real-time monitoring and feedback of temperature.

[0058] It can be understood that a total of three types of light need to be transmitted in the optical fiber 1, namely treatment light, temperature detection incident light and reflected light.

[0059] The optical fiber device for phototherapy provided by the embodiment of the present invention has the following beneficial effects:

[0060] 1. The optical fiber device for phototherapy proposed in the present invention can move the probe 11 through the minimally invasive interventional catheter to the venous blood vessel area to be treated under the navigation of magnetic resonance imaging, CT scanning, ultrasound or angiography X-ray machine, thereby realizing photothermal treatment of varicose veins through photothermal photosensitizers and real-time temperature monitoring of the treatment process using optical fiber temperature sensors, thereby ensuring the high efficiency of treatment, instant feedback of information and safety.

[0061] 2. Compared with traditional open varicose vein surgery, the optical fiber device for phototherapy proposed in the present invention has the advantages of minimal invasiveness, high efficiency, easy operation and few side effects; compared with conventional laser therapy and radiofrequency ablation therapy, it can monitor and control the treatment temperature in real time, reduce the patient's pain and avoid the occurrence of other complications.

[0062] 3. Different from conventional minimally invasive interventional treatment devices, the optical fiber device probe surface of the present invention can be selectively covered with a metal coating to visualize the varicose vein surgery process. Different coating types can be selected according to different treatment environments and medical imaging technologies, such as uncoated or other coatings that resist electromagnetic interference under MRI navigation, and metal coatings can be selected under angiography X-ray image navigation.

[0063] 4. Different from conventional fiber optic phototherapy, the optical fiber device for phototherapy proposed in the present invention is provided with a photothermal photosensitizer inside or on the surface of the front end. The photothermal photosensitizer acts as a photothermal converter. On the one hand, it improves the photothermal conversion efficiency, and on the other hand, it avoids the direct effect of strong laser on biological tissue. Only tens to two hundred milliwatts of therapeutic light can be used to utilize the photothermal effect of the front end of the optical fiber to generate high temperature for vascular closure treatment and elimination of varicose veins, which greatly improves safety and avoids complications such as skin damage, nerve damage, vascular bleeding and infection.

[0064] 5. The optical fiber device for phototherapy proposed in the present invention makes full use of the structure and material properties of the optical fiber, and fixes the photothermal photosensitizer on the surface of the optical fiber by hydrogen bonds, chemical bonds and electrostatic adsorption, thereby reducing the risk of residual optical fiber photosensitizer in blood vessels and improving treatment efficiency and safety.

[0065] 6. The optical fiber device for phototherapy proposed in the present invention is highly compatible with existing medical imaging technology and has strong scalability. It can be combined with a variety of imaging, sensing and treatment technologies according to medical needs to achieve accurate, efficient and safe treatment of related diseases.

[0066] The present invention uses specific examples to illustrate the principles and implementation methods of the present invention. The above examples are only used to help understand the method and core ideas of the present invention. At the same time, for those skilled in the art, according to the ideas of the present invention, there will be changes in the specific implementation methods and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. An optical fiber device for phototherapy, characterized in that: include: An optical fiber, one end of which is used as a probe for inserting into the human body, and the other end of which is used for inputting therapeutic light; A photothermal photosensitizer is coated on the outside of the probe to form a photothermal photosensitizer; The temperature sensor is arranged in the probe.

2. The optical fiber device for phototherapy according to claim 1, characterized in that: The probe is also coated with a tracer coating.

3. The optical fiber device for phototherapy according to claim 1, characterized in that: The photothermal photosensitive layer is ring-shaped.

4. The optical fiber device for phototherapy according to claim 2, characterized in that: The tracer coating is in the shape of a ring.

5. The optical fiber device for phototherapy according to claim 2, characterized in that: The probe is a truncated cone structure, and the small end of the probe is the distal end.

6. The optical fiber device for phototherapy according to claim 5, characterized in that: The temperature sensor is arranged at a position in the probe corresponding to the photothermal photosensitive layer.

7. The optical fiber device for phototherapy according to claim 6, characterized in that: The temperature sensor is an optical fiber temperature sensor.

8. The optical fiber device for phototherapy according to claim 1, characterized in that: The diameter of the optical fiber is greater than 400 microns.

9. A minimally invasive phototherapy device for varicose veins, characterized in that: It comprises a therapeutic light source module and the optical fiber device for phototherapy according to any one of claims 1 to 8, wherein the therapeutic light source module can input therapeutic light to an end of the optical fiber away from the probe.

10. The minimally invasive phototherapy device for varicose veins according to claim 9, characterized in that: It also includes an optical fiber temperature sensor addressing module. The temperature sensor in the optical fiber device for phototherapy is an optical fiber temperature sensor. The optical fiber temperature sensor addressing module can detect the reflected signal returned by the optical fiber temperature sensor.

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