Skin-care composition with sleep-aiding and anti-aging effects and preparation method of skin-care composition

Abstract

The invention relates to a skin care composition with sleep-aiding and anti-aging effects and a preparation method thereof. The skin care composition with the sleep-aiding and anti-aging effects comprises the following components in parts by mass: 3-15 parts of a humectant, 1-3 parts of an emulsifier, 3-10 parts of chitosan, 0.5-4 parts of an anti-aging active component, 0.5-4 parts of a sleep-aiding active component, 1-5 parts of a cross-linking agent, 0.5-2 parts of an antioxidant and 40-90 parts of a solvent, wherein the chitosan is prepared from hydrophilic chitosan and hydrophobic chitosan. Hydrophobic and hydrophilic modified chitosan is used for coating anti-aging and sleep-aiding active components to obtain microspheres, and then the microspheres are applied to the skin care composition, so that the stability of the product is improved, meanwhile, the product can more efficiently play a role in use, and the product also has multiple effects of moisturizing, moistening skin and the like, and has a good application prospect.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a skin care composition with sleep-aiding and anti-aging effects and a preparation method thereof. Background Art

[0002] With the increasing global aging population and rising health awareness, the market for sleep aids and anti-aging products is growing rapidly. The needs of a large number of people with sleep disorders and beauty consumers for sleep aids, calming nerves, and anti-aging have driven the development of product diversification. Oral tablets, drinks, and inhalation preparations are the current mainstream forms of sleep aids and anti-aging products. Products that combine sleep aids and anti-aging ingredients with skin care products are also a hot topic of current research.

[0003] Existing technologies such as CN109200176A, an anti-aging sleep-aiding wine, CN119385982A, a non-dependency anti-aging sleep-aiding preparation and its preparation method, CN119699589A, a composition containing ergothioneine with sleep-aiding, whitening, anti-aging and anti-inflammatory effects and its application, etc. all use a variety of different substances with sleep-aiding and anti-aging functions to compound, and are applied to beverages, food and other fields, and have achieved certain sleep-aiding and anti-aging effects.

[0004] However, active ingredients such as plant extracts are easily affected by light, heat, oxygen and humidity, and may be degraded or inactivated, and their effects are significantly reduced after long-term storage. In order to improve stability, the industry often uses microencapsulation technology to encapsulate active ingredients using wall materials such as cyclodextrin, liposomes, and chitosan to isolate them from the external environment. However, this protection mechanism may delay the release of active ingredients, causing the product to fail to take effect and be absorbed in a timely manner, and is not suitable for use in skin care products. In addition, most coating technologies still have shortcomings such as unsatisfactory effects, complex processes, and high costs, and still need to be further optimized to meet the market demand for efficient and stable sleep-aiding and anti-aging products.

[0005] Therefore, it is urgent to develop a new technical solution to solve the problems existing in the prior art. Summary of the invention

[0006] Based on this, the present invention provides a skin care composition with sleep-aiding and anti-aging effects and a preparation method thereof. The present invention uses hydrophobic and hydrophilic modified chitosan to coat the anti-aging and sleep-aiding active ingredients to obtain microspheres, which are then applied to the skin care composition, which not only improves the stability of the product, but also can more efficiently exert its efficacy during use, and also has multiple effects such as moisturizing and emollient, and has good application prospects.

[0007] One object of the present invention is to provide a skin care composition having sleep-aiding and anti-aging effects, wherein the skin care composition having sleep-aiding and anti-aging effects comprises the following components in parts by weight: 3-15 parts of moisturizer Emulsifier 1-3 parts Chitosan 3-10 parts 0.5-4 parts of anti-aging active ingredients 0.5-4 parts of active ingredients for sleep Crosslinking agent 1-5 parts 0.5-2 parts of antioxidant 40-90 parts of solvent; Wherein, the chitosan includes hydrophilic chitosan and hydrophobic chitosan.

[0008] Furthermore, the mass ratio of the hydrophilized chitosan to the hydrophobized chitosan is 1:(0.1-5).

[0009] Furthermore, the anti-aging active ingredients include resveratrol, quercetin, and ergothioneine; the sleep-aiding active ingredients include jujube saponin, linalyl acetate, and theanine.

[0010] Furthermore, the moisturizing agent includes glycerin, butylene glycol and sodium hyaluronate.

[0011] Furthermore, the hydrophilized chitosan is hydroxypropyl chitosan; and the hydrophobicized chitosan is polylactic acid-modified chitosan.

[0012] Furthermore, the preparation method of the polylactic acid modified chitosan comprises the following steps: Chitosan and lactic acid are mixed, heated and dehydrated, a catalyst is added, and vacuum heating reaction is performed to obtain polylactic acid modified chitosan.

[0013] Furthermore, the temperature of the heating dehydration is 70-120°C, and the temperature of the vacuum heating is 120-130°C.

[0014] Furthermore, the mass ratio of chitosan to lactic acid is 1:(10-50).

[0015] The polylactic acid modified chitosan of the present invention directly reacts lactic acid and chitosan by mixing them. Under the action of a catalyst, the carboxyl group of the polylactic acid and the amino group of the chitosan undergo an amidation reaction to obtain the modified chitosan with the polylactic acid chain segment introduced. The preparation process is simple, and the obtained product has better film-forming and coating properties, promotes the encapsulation of active substances to form microspheres, and has stronger hydrophobicity, thereby improving the stability of the composition.

[0016] Another object of the present invention is to provide a method for preparing the above-mentioned skin care composition having sleep-aiding and anti-aging effects, wherein the method for preparing the skin care composition having sleep-aiding and anti-aging effects comprises the following steps: S1, adding chitosan to acetic acid, then adding anti-aging active ingredients and sleep-aiding active ingredients with stirring, then adding a cross-linking agent, stirring for reaction, and drying to obtain an intermediate product; S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

[0017] Furthermore, the stirring reaction temperature is 20-30°C.

[0018] Furthermore, the cross-linking agent is sodium tripolyphosphate.

[0019] The present invention has the following beneficial effects: The present invention provides a skin care composition with sleep-aiding and anti-aging effects, wherein chitosan is used to coat sleep-aiding active ingredients and anti-aging active ingredients, and compounded with ingredients such as moisturizers. The chitosan is composed of hydrophilic hydroxypropyl chitosan and hydrophobic lactic acid-modified chitosan. On the one hand, the active groups and long chain segments therein can promote the adsorption and encapsulation of active ingredients, which is conducive to the formation of microspheres; on the other hand, after the two chitosans coat the active ingredients and cross-link to form microspheres, they have both hydrophilic and hydrophobic properties, and have better affinity with other components and solvents, thereby enhancing the stability of the emulsion composition and reducing the possibility of active ingredient failure after long-term storage. In addition, the chitosan-coated active ingredient microspheres of the present invention have good affinity with the skin. When used, they can more efficiently promote the release and absorption of active substances through kneading and friction (this may be related to the reduced thermal stability of hydroxypropyl chitosan and lactic acid-modified chitosan compared to unmodified chitosan), and the improvement of skin health and sleep quality is more obvious. In summary, the skin care composition with sleep-aiding and anti-aging effects of the present invention overcomes the defects existing in the prior art and provides a new idea for the development of skin care and health care products. DETAILED DESCRIPTION

[0020] In order to more clearly illustrate the technical solution of the present invention, the following examples are listed. Unless otherwise stated, the raw materials, reactions and post-treatment methods shown in the examples are common raw materials on the market and technical methods well known to those skilled in the art.

[0021] The words "preferred", "preferably", "more preferably", etc. in the present invention refer to embodiments of the present invention that can provide certain beneficial effects in certain circumstances. However, other embodiments may also be preferred under the same circumstances or other circumstances. In addition, the description of one or more preferred embodiments does not imply that other embodiments are not applicable, nor is it intended to exclude other embodiments from the scope of the present invention.

[0022] It should be understood that, except in any operating examples, or where otherwise indicated, all numbers indicating, for example, the amounts of ingredients used in the specification and claims should be understood to be modified in all cases by the term "about". Therefore, unless indicated to the contrary, the numerical parameters set forth in the following specification and the appended claims are approximate values ​​that vary depending on the desired properties to be obtained by the present invention.

[0023] The moisturizer in the embodiment of the present invention is glycerol, 1,3-butylene glycol and sodium hyaluronate in a mass ratio of 2.8:1:0.2.

[0024] The emulsifier in the embodiment of the present invention is PEG-100 stearate.

[0025] The anti-aging active ingredients in the embodiment of the present invention are resveratrol, quercetin and ergothioneine in a mass ratio of 1:1:1.

[0026] The sleep-aiding active ingredients in the embodiment of the present invention are jujube saponin, linalyl acetate and theanine in a mass ratio of 1:1:1.

[0027] The antioxidant in the embodiment of the present invention is vitamin E.

[0028] The solvent in the embodiment of the present invention is deionized water.

[0029] The chitosan in the examples of the present invention was purchased from Zhejiang Jinke Biological, and has a molecular weight of about 10,000.

[0030] The hydroxypropyl chitosan in the examples of the present invention was purchased from Maclean, CAS No.: 104673-29-2.

[0031] The acetic acid concentration in the embodiment of the present invention is 1 wt %.

[0032] The preparation method of polylactic acid modified chitosan in the embodiment of the present invention comprises the following steps: Chitosan and L-lactic acid were mixed at a mass ratio of 1:30, stirred and dissolved, and then dehydrated at 70°C under vacuum conditions for 3 h, then heated to 100°C for dehydration for 2 h, and finally heated to 120°C for dehydration for 1 h; After cooling, stannous octoate (0.03% of the mass of L-lactic acid) was added, mixed evenly, and reacted at 130°C under vacuum conditions for 5 h. The product was washed with acetone and dried to obtain polylactic acid-modified chitosan.

[0033] The "parts" in the embodiments of the present invention refer to parts by mass.

[0034] Example 1 A skin care composition with sleep-aiding and anti-aging effects, comprising the following components in parts by weight: 6 parts moisturizer Emulsifier 1 part 2 parts of Hydroxypropyl Chitosan 2 parts of polylactic acid modified chitosan 1.5 parts of anti-aging active ingredients 1.5 parts of active ingredients to help you sleep 1.5 parts of sodium tripolyphosphate 0.6 parts of antioxidant 40 parts of solvent; The preparation method of the skin care composition having sleep-aiding and anti-aging effects comprises the following steps: S1. According to the above mass fractions, hydroxypropyl chitosan and polylactic acid-modified chitosan are added to 1000 parts of acetic acid to obtain a chitosan solution, and then the anti-aging active ingredients and the sleep-aiding active ingredients are added with stirring, and then sodium tripolyphosphate is added, and the mixture is stirred at 30° C. for 1 h to react, and then centrifuged and dried to obtain an intermediate product; S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

[0035] Example 2 A skin care composition with sleep-aiding and anti-aging effects, comprising the following components in parts by weight: Moisturizer 10 parts 1.5 parts of emulsifier 3.5 parts of hydroxypropyl chitosan 3.5 parts of polylactic acid modified chitosan 2.5 parts of anti-aging active ingredients 2.2 servings of active ingredients to help you sleep 2.4 parts of sodium tripolyphosphate 1 part antioxidant 65 parts of solvent; The preparation method of the skin care composition having sleep-aiding and anti-aging effects comprises the following steps: S1. According to the above mass fractions, hydroxypropyl chitosan and polylactic acid-modified chitosan are added to 1000 parts of acetic acid to obtain a chitosan solution, and then the anti-aging active ingredients and the sleep-aiding active ingredients are added with stirring, and then sodium tripolyphosphate is added, and the mixture is stirred at 30° C. for 1 h to react, and then centrifuged and dried to obtain an intermediate product; S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

[0036] Example 3 A skin care composition with sleep-aiding and anti-aging effects, comprising the following components in parts by weight: 14 parts moisturizer Emulsifier 2.5 parts 5 parts of Hydroxypropyl Chitosan 5 parts of polylactic acid modified chitosan 3.5 parts of anti-aging active ingredients 3.5 parts of active ingredients to help you sleep 3.5 parts of sodium tripolyphosphate 1.5 parts antioxidant 90 parts of solvent; The preparation method of the skin care composition having sleep-aiding and anti-aging effects comprises the following steps: S1. According to the above mass fractions, hydroxypropyl chitosan and polylactic acid-modified chitosan are added to 1000 parts of acetic acid to obtain a chitosan solution, and then the anti-aging active ingredients and the sleep-aiding active ingredients are added with stirring, and then sodium tripolyphosphate is added, and the mixture is stirred at 30° C. for 1 h to react, and then centrifuged and dried to obtain an intermediate product; S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

[0037] Comparative Example 1 The difference between this comparative example and Example 1 is that the polylactic acid modified chitosan is replaced by an equal mass of unmodified chitosan, and the other components and preparation method are the same as those in Example 1.

[0038] Comparative Example 2 The difference between this comparative example and Example 1 is that hydroxypropyl chitosan is replaced by polylactic acid-modified chitosan of equal mass, and other components and preparation methods are the same as those in Example 1.

[0039] Test Case 50 volunteers aged 20-30 were selected and randomly divided into 5 groups, each with 10 people. Each group tried the composition samples prepared in Examples 1-3 or Comparative Examples 1-2. Each volunteer applied 5-8 g of the sample on the face before going to bed every day, massaged for 1 minute, and continued for 21 days.

[0040] Evaluation of sleep-aiding effect: The Pittsburgh Sleep Quality Index (PSQI) was used for scoring (the total score range is 0-21, the higher the score, the worse the sleep quality). The difference in scores before and after the trial was calculated, and the result was the average of each group of data.

[0041] Evaluation of anti-aging effect: After each group of people tried the sample for 21 days, they scored the improvement and enhancement of skin quality on a scale of 0-10, with 10 being the highest. The result was the average of each group's data.

[0042] The samples prepared in the examples and comparative examples were sealed and stored at a constant temperature of 30° C. for 2 months, and then the above test was performed again.

[0043] The test results are shown in Table 1.

[0044] Table 1 Test results According to Table 1, it can be concluded that the composition prepared in the embodiment of the present invention can effectively play a role in helping sleep and anti-aging, has a significant improvement effect on sleep quality and skin quality, and can still play a strong effect after long-term storage. However, the technical effect of Comparative Examples 1-2, which replaced hydroxypropyl chitosan or polylactic acid-modified chitosan, was significantly reduced. This is because the stability of the composition, the coating effect on the active ingredient, and the release and absorption effect of the active ingredient were all reduced. After long-term storage, the technical effect of the comparative example further decreased, and the ideal effect of improving sleep and moisturizing the skin could not be obtained.

[0045] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered exemplary and non-restrictive in all respects, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims be included in the present invention.

[0046] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A skin care composition having sleep-aiding and anti-aging effects, characterized in that: The skin care composition with sleep-aiding and anti-aging effects comprises the following components in parts by weight: 3-15 parts of moisturizer Emulsifier 1-3 parts Chitosan 3-10 parts 0.5-4 parts of anti-aging active ingredients 0.5-4 parts of active ingredients for sleep Crosslinking agent 1-5 parts 0.5-2 parts of antioxidant 40-90 parts of solvent; Wherein, the chitosan includes hydrophilic chitosan and hydrophobic chitosan.

2. The skin care composition having sleep-aiding and anti-aging effects according to claim 1, characterized in that: The anti-aging active ingredients include resveratrol, quercetin, and ergothioneine; the sleep-aiding active ingredients include jujube saponin, linalyl acetate, and theanine.

3. The skin care composition having sleep-aiding and anti-aging effects according to claim 1, characterized in that: The humectants include glycerin, butylene glycol and sodium hyaluronate.

4. The skin care composition with sleep-aiding and anti-aging effects according to claim 1, characterized in that: The hydrophilized chitosan is hydroxypropyl chitosan; and the hydrophobicized chitosan is polylactic acid-modified chitosan.

5. The skin care composition having sleep-aiding and anti-aging effects according to claim 4, characterized in that: The preparation method of the polylactic acid modified chitosan comprises the following steps: Chitosan and lactic acid are mixed, heated and dehydrated, a catalyst is added, and vacuum heating reaction is performed to obtain polylactic acid modified chitosan.

6. The skin care composition with sleep-aiding and anti-aging effects according to claim 5, characterized in that: The temperature of the heating dehydration is 70-120°C, and the temperature of the vacuum heating is 120-130°C.

7. The skin care composition with sleep-aiding and anti-aging effects according to claim 5, characterized in that: The mass ratio of chitosan to lactic acid is 1:(10-50).

8. A method for preparing the skin care composition having sleep-aiding and anti-aging effects according to any one of claims 1 to 7, characterized in that: The preparation method of the skin care composition having sleep-aiding and anti-aging effects comprises the following steps: S1, adding chitosan to acetic acid, then adding anti-aging active ingredients and sleep-aiding active ingredients with stirring, then adding a cross-linking agent, stirring for reaction, and drying to obtain an intermediate product; S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

9. The method for preparing the skin care composition having sleep-aiding and anti-aging effects according to claim 8, characterized in that: The temperature of the stirring reaction is 20-30°C.

10. The method for preparing the skin care composition having sleep-aiding and anti-aging effects according to claim 8, characterized in that: The cross-linking agent is sodium tripolyphosphate.

Images