Quaternary ammonium salt type antibacterial hand-washing-free disinfectant and preparation method thereof

Abstract

The invention relates to the field of disinfectants, and particularly discloses a quaternary ammonium salt type antibacterial hand-washing-free disinfectant and a preparation method thereof. The disinfectant is prepared from the following raw materials in parts by weight: 0.15 to 0.25 part of quaternary ammonium salt; 2.7 to 3.2 parts of glycerol; 0.08 to 0.15 part of a chelating agent; 0.17 to 0.5 part of hydroxyethyl cellulose; 3-5 parts of a skin care agent; and 90.9 to 93.9 parts of deionized water. The preparation method comprises the following steps: taking the raw materials according to the ratio, respectively dissolving and uniformly mixing, and adjusting the pH value to 6.5-7.5, thereby obtaining the hand-washing-free disinfectant. The disinfectant disclosed by the invention can be used for rapidly and effectively sterilizing and improving the damage condition of the disinfectant to the skin at the same time.

Description

Technical Field

[0001] The present application relates to the field of disinfectants, and more specifically, to a quaternary ammonium salt-type antibacterial hand-free disinfectant and a preparation method thereof. Background Art

[0002] Before and after surgical operations in hospitals, hand disinfection of medical staff is an important part of infection prevention. Correct hand disinfection steps can significantly reduce the risk of surgical site infection, and the disinfectant used in hand disinfection is the key.

[0003] Commonly used hand sanitizers are alcohol disinfectants, such as ethanol-containing disinfectants, which are widely used in the medical and personal care fields due to their fast and effective bactericidal ability. However, frequent use of ethanol-containing hand sanitizers may cause dryness and dehydration of the skin, and even dermatitis or allergic reactions. Long-term contact may cause damage to the skin barrier function. Summary of the invention

[0004] In order to improve the damage to the skin caused by disinfectants while quickly and effectively killing bacteria, the present application provides a quaternary ammonium salt antibacterial hand-free disinfectant and a preparation method thereof.

[0005] In the first aspect, the present application provides a quaternary ammonium salt antibacterial hand-free disinfectant, which adopts the following technical solution: A quaternary ammonium salt antibacterial hand-free disinfectant, comprising the following raw materials in parts by weight: 0.15~0.25 parts of quaternary ammonium salt Glycerin 2.7-3.2 parts Chelating agent 0.08~0.15 parts Hydroxyethyl cellulose 0.17~0.5 parts 3-5 parts of skin care agent 90.9-93.9 parts of deionized water.

[0006] By adopting the above technical scheme, since quaternary ammonium salt is used as the main disinfection ingredient and there is no alcohol, skin damage can be significantly reduced and excellent bactericidal and disinfecting effects can be maintained. In addition, the addition of a skin care agent can further reduce skin damage, maintain the skin barrier, repair damaged skin, and prolong the residual time of the quaternary ammonium salt on the hands, thereby prolonging the bactericidal and disinfecting effect. Therefore, the effect of improving the damage to the skin caused by the disinfectant while quickly and effectively sterilizing is achieved.

[0007] Optionally, the quaternary ammonium salt comprises didecyldimethylammonium chloride and didecylmethylhydroxyethylammonium chloride in a weight ratio of 1:1.

[0008] By adopting the above technical scheme, didecyl dimethyl ammonium chloride and didecyl methyl hydroxyethyl ammonium chloride are both broad-spectrum antibacterial agents with good surface activity and bactericidal effects, and didecyl methyl hydroxyethyl ammonium chloride contains a hydroxyethyl functional group, which can enhance its adhesion and moisturizing effect on the skin. The combination of the two has stronger bactericidal and skin care effects.

[0009] Optionally, the skin care agent comprises loofah stock solution, alginate and acetyl hexapeptide-8 in a weight ratio of 4:2:1.

[0010] By adopting the above technical scheme, acetyl hexapeptide-8 can reduce dynamic wrinkles by inhibiting the release of neurotransmitters and reducing muscle contraction, thus having an anti-wrinkle effect and can effectively reduce water loss and the attachment of pathogens. The loofah stock solution is rich in polysaccharides, vitamin C, vitamin E and minerals, has good moisturizing and antioxidant effects, can help lock in skin moisture, prevent dryness caused by frequent use of disinfectants, and also has certain anti-inflammatory and soothing effects, which helps to repair damaged skin; at the same time, alginate can form a protective film on the skin surface. The alginate molecules contain a large number of hydroxyl groups (-OH), which can form hydrogen bonds with the water molecules locked in the loofah stock solution, thereby enhancing the skin's moisturizing ability. The film formed by alginate can slowly release the antibacterial ingredients quaternary ammonium salts and acetyl hexapeptide-8 and loofah stock solution on the skin surface, prolonging their residence time on the skin, providing more lasting antibacterial protection and additional barrier protection, preventing the invasion of external pollutants and pathogens, and also has a certain effect of promoting wound healing, which is suitable for cases with minor skin injuries.

[0011] Optionally, the preparation method of the skin care agent is: take alginate and acetyl hexapeptide-8 according to a ratio, add them to the loofah stock solution, and stir and mix until uniform.

[0012] Optionally, the chelating agent is disodium ethylenediaminetetraacetate.

[0013] Optionally, the hand-free disinfectant further comprises 0.4 to 0.6 parts by weight of hydroxypropyl methylcellulose and 0.1 to 0.2 parts by weight of polyvinyl pyrrolidone.

[0014] By adopting the above technical scheme, hydroxypropyl methylcellulose can wrap part of the quaternary ammonium salt to form antibacterial sustained-release microcapsules, thereby prolonging the release time of the quaternary ammonium salt and enhancing the bactericidal and disinfecting effects. The antibacterial sustained-release microcapsules are compounded with skin care agents and can stay on the hands better under the action of the skin care agents, which can not only prolong the bactericidal and disinfecting effects, but also reduce skin damage; polyvinyl pyrrolidone can effectively improve the dispersibility of the antibacterial sustained-release microcapsules and improve the compatibility of the raw materials in the disinfectant.

[0015] In a second aspect, the present application provides a method for preparing a quaternary ammonium salt antibacterial hand-free disinfectant, using the following technical solution: A method for preparing a quaternary ammonium salt antibacterial hand-free disinfectant comprises the following steps: Prepare the raw materials according to the ratio, add the quaternary ammonium salt to part of the deionized water and stir until completely dissolved, add glycerin and the skin care agent to the remaining deionized water and stir until completely dissolved, slowly pour the solution containing the quaternary ammonium salt into the solution containing glycerin and the skin care agent and stir until evenly mixed, then add the chelating agent and hydroxyethyl cellulose in turn and stir until completely dissolved, mix the raw materials evenly, adjust the pH to 6.5-7.5, and you can prepare a hand-free disinfectant.

[0016] By adopting the above technical solution, by adding raw materials and mixing them step by step, the raw materials of the prepared disinfectant can be fully combined, achieving a good bactericidal and disinfecting effect and an effect of reducing skin damage.

[0017] In a third aspect, the present application provides a method for preparing a quaternary ammonium salt antibacterial hand-free disinfectant, using the following technical solution: A method for preparing a quaternary ammonium salt antibacterial hand-free disinfectant comprises the following steps: Prepare the raw materials according to the ratio, take half of the quaternary ammonium salt and completely dissolve it in part of deionized water, take hydroxypropyl methylcellulose and completely dissolve it in part of deionized water, mix the two solutions until they are uniform, emulsify, use the quaternary ammonium salt as the capsule core and the hydroxypropyl methylcellulose as the capsule wall, and prepare the antibacterial sustained-release microcapsules by spray drying; The other half of the quaternary ammonium salt is added to part of the deionized water and stirred until completely dissolved. Glycerin and a skin care agent are added to the remaining deionized water and stirred until completely dissolved. The solution containing the other half of the quaternary ammonium salt is slowly poured into the solution containing glycerin and the skin care agent and stirred until uniformly mixed. Antibacterial sustained-release microcapsules and polyvinyl pyrrolidone are then added and stirred until uniformly mixed. Then, a chelating agent and hydroxyethyl cellulose are added in sequence and stirred until completely dissolved. All raw materials are mixed uniformly, and the pH is adjusted to 6.5-7.5 to prepare a hand-free disinfectant.

[0018] By adopting the above technical solution, the preparation of antibacterial sustained-release microcapsules effectively increases the bactericidal and disinfecting effect time of the disinfectant.

[0019] In summary, this application has the following beneficial effects: 1. Since the present application adopts quaternary ammonium salt as the main disinfection ingredient and does not contain alcohol, it can significantly reduce skin damage and maintain excellent bactericidal and disinfection effects. In addition, the addition of skin care agents can further reduce skin damage, maintain the skin barrier, repair damaged skin, and prolong the residual time of quaternary ammonium salt on the hands, prolonging the bactericidal and disinfection effects. Therefore, the effect of improving the damage of the disinfectant to the skin while achieving rapid and effective sterilization is achieved.

[0020] 2. In the present application, didecyl dimethyl ammonium chloride and didecyl methyl hydroxyethyl ammonium chloride are both broad-spectrum antibacterial agents with good surface activity and bactericidal effects, and didecyl methyl hydroxyethyl ammonium chloride contains a hydroxyethyl functional group, which can enhance its adhesion and moisturizing effect on the skin. The combination of the two has stronger bactericidal and skin care effects.

[0021] 3. The method of the present application, by adding raw materials and mixing them step by step, the raw materials of the prepared disinfectant can be fully combined, achieving a good bactericidal and disinfecting effect and reducing skin damage. DETAILED DESCRIPTION

[0022] The present application is further described in detail with reference to the following examples. It is specially noted that if no specific conditions are specified in the following examples, the conventional conditions or the conditions recommended by the manufacturer are followed, and the raw materials used in the following examples can be obtained from common commercial sources unless otherwise specified.

[0023] Didecyldimethylammonium chloride, DDAC, Cas number: 7173-51-5.

[0024] Didecylmethylhydroxyethylammonium chloride, DEQ, was purchased from Shandong Jiapeng New Materials Co., Ltd.

[0025] Glycerol, reagent grade, content 99%.

[0026] Disodium ethylenediaminetetraacetate, Cas number: 139-33-3.

[0027] Hydroxyethyl cellulose, 250~450mpa.s, 25℃.

[0028] The loofah stock solution is squeezed from fresh loofah and loofah vine, and the loofah squeezed liquid and loofah vine squeezed liquid each account for 50% by weight.

[0029] Alginate, also known as sodium alginate, brand name Shenghe Chemical, food grade.

[0030] Acetyl hexapeptide-8, Cas number: 616204-22-9, was purchased from Suzhou Modif Biotechnology Co., Ltd.

[0031] Hydroxypropyl methylcellulose, specifications: USP2910, 2% viscosity: 15mPa.s, methoxy: 28-30%; hydroxypropyl: 7.0-12%.

[0032] Polyvinyl pyrrolidone, average molecular weight 8000, K17.

[0033] Preparation Example 1 The skin care agent includes 4kg of loofah stock solution, 2kg of alginate and 1kg of acetyl hexapeptide-8.

[0034] The preparation method is as follows: alginate and acetyl hexapeptide-8 are taken according to a ratio, added into the loofah stock solution, and stirred at a speed of 500 rpm until uniform.

[0035] Preparation Example 2 The skin care agent includes 4kg of loofah stock solution and 2kg of alginate.

[0036] The preparation method is as follows: add alginate into the loofah stock solution according to the ratio, and stir and mix at a speed of 500 rpm until the mixture is uniform.

[0037] Preparation Example 3 The skin care agent includes 4kg of loofah stock solution and 1kg of acetyl hexapeptide-8.

[0038] The preparation method is as follows: take acetyl hexapeptide-8 according to the ratio, add it into the loofah stock solution, and stir and mix at a speed of 500 rpm until it is uniform.

[0039] Preparation Example 4 The skin care agent includes 4 kg alginate and 2 kg acetyl hexapeptide-8.

[0040] The preparation method is as follows: alginate and acetyl hexapeptide-8 are taken according to the ratio, and stirred at a speed of 500 rpm until they are uniform. Example

[0041] Example 1 A quaternary ammonium salt antibacterial hand-free disinfectant, comprising the following raw materials: Quaternary ammonium salt, the quaternary ammonium salt includes didecyl dimethyl ammonium chloride (DDAC) and didecyl methyl hydroxyethyl ammonium chloride (DEQ) in a weight ratio of 1:1; glycerol; chelating agent, the chelating agent is disodium ethylenediaminetetraacetate; hydroxyethyl cellulose; the skin care agent prepared in Preparation Example 1; deionized water. The amount of each raw material is shown in Table 1.

[0042] A method for preparing a quaternary ammonium salt antibacterial hand-free disinfectant comprises the following steps: Prepare the raw materials according to the ratio, add the quaternary ammonium salt to one-tenth of deionized water and stir until completely dissolved, add glycerin and skin care agent to the remaining deionized water and stir until completely dissolved, slowly pour the solution containing the quaternary ammonium salt into the solution containing glycerin and skin care agent and stir until evenly mixed, then add the chelating agent and hydroxyethyl cellulose in turn and stir until completely dissolved, mix the raw materials evenly, adjust the pH to 6.5, and you can make a hand-free disinfectant.

[0043] Example 2 The difference between this embodiment and embodiment 1 is that the amounts of various raw materials are different, see Table 1 for details.

[0044] During the preparation step, the pH was adjusted to 6.8.

[0045] Example 3 The difference between this embodiment and embodiment 1 is that the amounts of various raw materials are different, see Table 1 for details.

[0046] During the preparation step, the pH was adjusted to 7.5.

[0047] Example 4 The difference between this embodiment and embodiment 2 is that all quaternary ammonium salts are didecyldimethylammonium chloride.

[0048] Example 5 The difference between this embodiment and embodiment 2 is that all quaternary ammonium salts are didecylmethylhydroxyethylammonium chloride.

[0049] Example 6 The difference between this embodiment and embodiment 2 is that the skin care agent is prepared by preparation example 2.

[0050] Example 7 The difference between this embodiment and embodiment 2 is that the skin care agent is prepared by preparation example 3.

[0051] Example 8 The difference between this embodiment and embodiment 2 is that the skin care agent is prepared by Preparation Example 4.

[0052] Example 9 The difference between this embodiment and embodiment 2 is that the skin care agent is loofah stock solution.

[0053] Example 10 The difference between this embodiment and embodiment 2 is that the skin care agent is alginate.

[0054] Embodiment 11 The difference between this embodiment and embodiment 2 is that the skin care agent is acetyl hexapeptide-8.

[0055] Example 12 The difference between this embodiment and embodiment 2 is that the hand-free disinfectant further includes hydroxypropyl methylcellulose and polyvinyl pyrrolidone. The specific amounts are shown in Table 1.

[0056] A method for preparing a quaternary ammonium salt antibacterial hand-free disinfectant comprises the following steps: Prepare the raw materials according to the ratio, take half of the quaternary ammonium salt and completely dissolve it in one-twentieth of deionized water, take hydroxypropyl methylcellulose and completely dissolve it in one-tenth of deionized water, mix the two solutions until uniform, and form an aqueous phase. Add Tween 80 to olive oil and mix until uniform. The amount of olive oil is five times that of hydroxypropyl methylcellulose, and the amount of Tween 80 is one-tenth of the amount of olive oil to form an oil phase. Slowly add the oil phase to the aqueous phase, preliminarily mix, and then use a homogenizer for preliminary emulsification for 10 minutes, and then use a high shear homogenizer for further emulsification for 10 minutes, the speed is 20000rpm, and the temperature is 37℃. Cool to room temperature and sieve to remove impurities. With quaternary ammonium salt as the capsule core and hydroxypropyl methylcellulose as the capsule wall, antibacterial sustained-release microcapsules are prepared by spray drying. The feed rate of spray drying is 20ml / min, the inlet air temperature is 170℃, the outlet air temperature is 90℃, the atomization pressure is 0.2MPa, and the particle size is 10μm.

[0057] Take the other half of the quaternary ammonium salt and add it to one twentieth of deionized water, stir until completely dissolved, take glycerol and skin care agent and add them to the remaining deionized water, stir until completely dissolved, slowly pour the solution containing the other half of the quaternary ammonium salt into the solution containing glycerol and skin care agent, stir until mixed evenly, then add antibacterial sustained-release microcapsules and polyvinyl pyrrolidone, stir until mixed evenly, then add chelating agent and hydroxyethyl cellulose in turn, stir until completely dissolved, mix all the raw materials evenly, adjust the pH to 6.5, and the hand-free disinfectant can be prepared.

[0058] Example 13 The difference between this embodiment and embodiment 12 is that the amounts of various raw materials are different, see Table 1 for details.

[0059] During the preparation step, the pH was adjusted to 6.8.

[0060] Embodiment 14 The difference between this embodiment and embodiment 12 is that the amounts of various raw materials are different, see Table 1 for details.

[0061] During the preparation step, the pH was adjusted to 7.5.

[0062] Embodiment 15 The difference between this embodiment and embodiment 13 is that hydroxypropyl methylcellulose does not form antibacterial sustained-release microcapsules with quaternary ammonium salts, but is added to the mixed solution as one of the raw materials together with polyvinyl pyrrolidone.

[0063] Example 16 The difference between this embodiment and embodiment 13 is that no hydroxypropyl methylcellulose is used in this embodiment, that is, no antibacterial sustained-release microcapsules are prepared.

[0064] Embodiment 17 The difference between this embodiment and embodiment 13 is that there is no polyvinyl pyrrolidone in this embodiment.

[0065] Table 1 Amount and source of disinfectant raw materials in each embodiment

[0066] Comparative Example 1 This comparative example is a commercially available 75% ethanol disinfectant.

[0067] Comparative Example 2 The difference between this comparative example and Example 2 is that there is no skin care agent.

[0068] Performance testing Detection Methods 1. On-site test of hand disinfection

[0069] A total of 19 groups of disinfectants in various embodiments and comparative examples were used as samples, and 10 samples were taken from each group.

[0070] On-site hand disinfection test: In the operating room of a hospital, 57 medical staff and patients were randomly selected as subjects and divided into 19 groups, with 3 medical staff and 3 patients in each group. Before disinfection, all subjects rubbed their hands together, put the five fingers of the left hand together, soaked a sterile cotton swab in a test tube containing 10ml of diluent, and squeezed it on the wall of the tube, and then rubbed each finger from the tip to the root of the five fingers twice (rotate the cotton swab once for each rub) to collect samples. Then cut the sampling end of the cotton swab into the diluent test tube in a sterile manner as a positive control sample.

[0071] The above disinfectant samples were used to disinfect the five fingers of the right hand of the subjects from the fingertips to the bases using the above method, and then the samples were collected 30 seconds after disinfection, 15 minutes after disinfection, and 45 minutes after disinfection, as the test group samples. At the same time, the unused disinfectant samples, diluents and cotton swabs of the same batch were used as negative control group samples.

[0072] Take 1 ml of samples from the test group, positive control group and negative control group respectively, inoculate 2 plates with each sample by agar pouring method, place in a 37℃ constant temperature box for 48 hours, count the number of colonies, and calculate the sterilization rate. The test results show that there is no bacterial growth in the negative control group, so the test is effective. The average sterilization rate of each group of subjects after testing is shown in Table 2.

[0073] 2. Skin moisturizing effect test 19 groups of subjects with similar body characteristics were selected, with 3 subjects in each group. According to the daily hand washing method and habit, the subjects washed their right hands with water and dried them with a dryer for 100 s. The skin humidity of the central part of the back of the right hand of the initial subjects was tested with a skin humidity tester. Then, the subjects were disinfected with disinfectants prepared in different embodiments and comparative examples. The skin humidity of the same part of the subjects at different times after disinfection was tested, and the average value was taken for each group. The test results are shown in Table 2.

[0074] Table 2 Test results of various embodiments and comparative examples

[0075] It can be seen from Example 2 and Comparative Example 1 and Table 2 that the disinfectant prepared in the present application can quickly and effectively kill bacteria while improving the damage to the skin caused by the disinfectant, and can also extend the disinfection time and reduce the subsequent invasion of germs on the hands.

[0076] It can be seen from Example 2, Example 4 and Example 5 and Table 2 that the compound use of didecyl dimethyl ammonium chloride and didecyl methyl hydroxyethyl ammonium chloride has a stronger bactericidal effect.

[0077] In combination with Example 2, Comparative Example 2, Examples 6 to 11 and Table 2, it can be seen that the skin care agent used in the present application can be effectively combined with the quaternary ammonium salt, which can not only quickly and effectively kill bacteria, but also prolong the residual time of the quaternary ammonium salt on the hands, prolong the bactericidal effect, and provide good water-locking and soothing effects, repair damaged skin, form a skin barrier, and reduce skin damage and re-invasion of pathogens.

[0078] In combination with Example 2, Example 13, Example 15 to Example 17 and Table 2, it can be seen that hydroxypropyl methylcellulose can wrap part of the quaternary ammonium salt to form an antibacterial sustained-release microcapsule, thereby prolonging the release time of the quaternary ammonium salt and enhancing the bactericidal and disinfecting effect. The antibacterial sustained-release microcapsule is compounded with a skin care agent and can stay on the hands better under the action of the skin care agent, which can not only prolong the bactericidal and disinfecting effect, but also reduce skin damage; polyvinyl pyrrolidone can effectively improve the dispersibility of the antibacterial sustained-release microcapsule, improve the compatibility of the raw materials in the disinfectant, and thereby enhance the effects of the antibacterial sustained-release microcapsule and the skin care agent.

[0079] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A quaternary ammonium salt antibacterial hand-free disinfectant, characterized in that: The invention comprises the following raw materials in parts by weight: 0.15-0.25 parts of quaternary ammonium salt; Glycerin 2.7-3.2 parts; Chelating agent 0.08-0.15 parts; Hydroxyethyl cellulose 0.17-0.5 parts; 3-5 parts of skin care agent; 90.9-93.9 parts of deionized water.

2. A quaternary ammonium salt antibacterial hand-free disinfectant according to claim 1, characterized in that: The quaternary ammonium salt includes didecyl dimethyl ammonium chloride and didecyl methyl hydroxyethyl ammonium chloride in a weight ratio of 1:

1.

3. A quaternary ammonium salt antibacterial hand-free disinfectant according to claim 1, characterized in that: The skin care agent comprises loofah stock solution, alginate and acetyl hexapeptide-8 in a weight ratio of 4:2:

1.

4. A quaternary ammonium salt antibacterial hand-free disinfectant according to claim 3, characterized in that: The preparation method of the skin care agent is as follows: alginate and acetyl hexapeptide-8 are taken according to a ratio, added into the loofah stock solution, and stirred and mixed until uniform.

5. A quaternary ammonium salt antibacterial hand-free disinfectant according to claim 1, characterized in that: The chelating agent is disodium ethylenediaminetetraacetate.

6. A quaternary ammonium salt antibacterial hand-free disinfectant according to claim 1, characterized in that: The hand-free disinfectant also includes 0.4 to 0.6 parts by weight of hydroxypropyl methylcellulose and 0.1 to 0.2 parts by weight of polyvinyl pyrrolidone.

7. A method for preparing a quaternary ammonium salt antibacterial hand-free disinfectant according to any one of claims 1 to 5, characterized in that: The following steps are involved: Prepare the raw materials according to the ratio, add the quaternary ammonium salt to part of the deionized water and stir until completely dissolved, add glycerin and the skin care agent to the remaining deionized water and stir until completely dissolved, slowly pour the solution containing the quaternary ammonium salt into the solution containing glycerin and the skin care agent and stir until evenly mixed, then add the chelating agent and hydroxyethyl cellulose in turn and stir until completely dissolved, mix the raw materials evenly, adjust the pH to 6.5-7.5, and you can prepare a hand-free disinfectant.

8. The method for preparing a quaternary ammonium salt antibacterial hand-free disinfectant according to claim 6, characterized in that: The following steps are involved: Prepare the raw materials according to the ratio, take half of the quaternary ammonium salt and completely dissolve it in part of deionized water, take hydroxypropyl methylcellulose and completely dissolve it in part of deionized water, mix the two solutions until they are uniform, emulsify, use the quaternary ammonium salt as the capsule core and the hydroxypropyl methylcellulose as the capsule wall, and prepare the antibacterial sustained-release microcapsules by spray drying; The other half of the quaternary ammonium salt is added to part of the deionized water and stirred until completely dissolved. Glycerin and a skin care agent are added to the remaining deionized water and stirred until completely dissolved. The solution containing the other half of the quaternary ammonium salt is slowly poured into the solution containing glycerin and the skin care agent and stirred until uniformly mixed. Antibacterial sustained-release microcapsules and polyvinyl pyrrolidone are then added and stirred until uniformly mixed. Then, a chelating agent and hydroxyethyl cellulose are added in sequence and stirred until completely dissolved. All raw materials are mixed uniformly, and the pH is adjusted to 6.5-7.5 to prepare a hand-free disinfectant.

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