Foot bath powder for treating premature ovarian insufficiency and preparation method thereof

Abstract

The invention relates to a foot bath powder for treating premature ovarian insufficiency and a preparation method thereof, according to a Yao medicine foot bath composition provided by the invention, through stimulation of foot meridians and acupoints, effective components of the medicine are absorbed through skin and directly reach a disease site, so that the effects of tonifying kidney and replenishing essence, conditioning Chong and Ren channels, promoting blood circulation to remove blood stasis and nourishing blood and tranquilizing are achieved; therefore, ovarian functions are improved, various symptoms caused by premature ovarian insufficiency are relieved, and the traditional Chinese medicine composition is suitable for being popularized and applied clinically and at home.

Description

[Technical field]

[0001] The invention relates to the technical field of traditional Chinese medicine compositions, and in particular to a foot bath powder for treating premature ovarian insufficiency and a preparation method thereof. [Background technology]

[0002] Premature ovarian insufficiency (POI) is one of the difficult and complicated diseases in women of childbearing age, with a prevalence of 1%-3%. It refers to the decline or loss of ovarian function in women before the age of 40. Most patients seek medical treatment due to infertility and menstrual disorders. Some patients have perimenopausal symptoms such as hot flashes, sweating, anxiety, depression, vaginal dryness, and insomnia. In the long term, there are complications such as osteoporosis and cardiovascular disease, which seriously affect women's fertility and physical and mental health. With the increasing prevalence of POI in recent years and the younger age, if it is not diagnosed and treated in time, the possibility of resuming ovulation in the future will become smaller and smaller. However, the pathogenesis of POI is unclear, and Western medicine lacks effective means to restore ovarian function. The currently recognized hormone replacement therapy has many contraindications and adverse reactions, and it is easy to relapse after discontinuation of the drug, and most patients are resistant.

[0003] Traditional Chinese medicine has unique advantages in the treatment of premature ovarian insufficiency. Among them, foot bath therapy, as an external treatment method, has the advantages of simple operation and few side effects, and is attracting more and more attention. [Summary of the invention]

[0004] In view of the above, it is necessary to provide a foot bath powder for treating premature ovarian insufficiency and a preparation method thereof. The foot bath powder can play the role of nourishing the kidney and replenishing essence, regulating Chong and Ren meridians, promoting blood circulation and removing blood stasis, nourishing blood and calming the mind, thereby improving ovarian function and alleviating various symptoms caused by premature ovarian insufficiency.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is:

[0006] A foot bath powder for treating premature ovarian insufficiency, the foot bath powder is composed of the following raw materials in parts by weight: 35-45 parts of Polygonum multiflorum, 35-45 parts of Sargentodoxa chinensis, 15-25 parts of Millettia spatholobi, 45-55 parts of Polygonum multiflorum, 15-25 parts of Rubia cordifolia, 15-25 parts of Herba speranskiae radix, 10-20 parts of Prunella vulgaris leaves, 15-25 parts of Herba schizonepetae and 15-25 parts of Caulis scopariae tenuifoliae.

[0007] Furthermore, the foot bath powder is composed of the following raw materials in parts by weight: 40 parts of Polygonum multiflorum, 40 parts of Sargentodoxa chinensis, 20 parts of Millettia spatholobi, 50 parts of Polygonum multiflorum, 20 parts of Rubia cordifolia, 20 parts of Herba spermi spermi, 15 parts of Prunus persica, 20 parts of Herba Lycopodii, and 20 parts of Caulis Spatholobi.

[0008] The present invention also provides a method for preparing the above-mentioned foot bath powder for treating premature ovarian insufficiency, the method comprising the following steps:

[0009] (1) The raw materials are cleaned and impurities removed, and then dried until the moisture content is less than 10%;

[0010] (2) The dried API is crushed into a particle size of 2-3 mm by a coarse grinder, and then finely crushed into a particle size of 100-200 mesh by an ultrafine grinder;

[0011] (3) putting the ultrafinely crushed raw materials into a blender and mixing them for 50-60 minutes to obtain a foot bath powder;

[0012] (4) The mixed foot bath powder is packaged.

[0013] Furthermore, the drying in step (1) is performed by hot air drying at a temperature of 50-60°C.

[0014] Furthermore, before packaging, the foot bath powder obtained after mixing is sterilized by cobalt-60 irradiation sterilization, and the irradiation dose is 20 kGy.

[0015] The foot bath powder obtained by the above combination and preparation method is prepared into a foot bath medicine in the following manner:

[0016] (1) Take an appropriate amount of medicine powder, add an appropriate amount of clean water, and soak for 30 minutes.

[0017] (2) After boiling, simmer over low heat for 30 minutes and filter out the liquid.

[0018] (3) Pour the medicinal solution into the foot bath, add appropriate amount of warm water, and adjust the water temperature to 40-45℃.

[0019] Directions:

[0020] (1) Soak your feet for 20-30 minutes every night before going to bed, once a day.

[0021] (2) One course of treatment is one month of continuous use, and generally 2-3 courses are used.

[0022] Note:

[0023] (1) Keep warm during foot bath to avoid catching cold.

[0024] (2) Dry your feet immediately after foot bath and put on socks.

[0025] (3) Use with caution during pregnancy, menstruation, or on occasions with damaged skin.

[0026] The present invention has at least the following beneficial effects:

[0027] 1. The present invention discloses a Yao medicine foot bath composition for treating premature ovarian insufficiency and a preparation method thereof. The composition is composed of raw materials such as Polygonum multiflorum, Sargentophyllum grandiflorum, Millettia spatholobi, and Radix Polygoni Multiflori, and has the effects of tonifying the kidney and replenishing essence, regulating Chong and Ren meridians, promoting blood circulation and removing blood stasis, nourishing blood and calming the mind, and can effectively improve the clinical symptoms of patients with premature ovarian insufficiency. The Chinese medicine foot bath composition of the present invention has a scientific formula, definite efficacy, safe use, simple operation, and is easy to promote.

[0028] 2. The foot bath powder of the present invention is administered through the foot, thus avoiding the side effects of oral medications and being easy to use.

[0029] 3. The present invention adopts a coarse pulverizer in combination with ultrafine pulverization technology, which greatly increases the specific surface area of ​​the drug, making it easier for the active ingredients of the drug to penetrate and absorb through the foot skin, thereby improving the bioavailability of the drug and enhancing the efficacy of the product. Compared with the foot bath powder prepared by the traditional pulverization method, the Chinese medicine foot bath powder of the present invention has a greatly improved absorption rate of the active ingredients under the same use conditions.

[0030] 4. The present invention adopts the cobalt-60 irradiation sterilization method, which effectively kills microorganisms without affecting the drug components and activity, thereby ensuring the safety of the product. At the same time, the Chinese medicine foot bath powder of the present invention does not add any chemical preservatives and additives, has no toxic side effects on the human body, and can be used safely for a long time. [Specific implementation method]

[0031] In order to make the above-mentioned purpose, features and advantages of the present invention more obvious and easy to understand, the specific implementation of the present invention is described in detail below. In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present invention, so the present invention is not limited by the specific implementation disclosed below.

[0032] Embodiment 1:

[0033] The present embodiment provides a foot bath powder for treating premature ovarian insufficiency, characterized in that the foot bath powder is composed of the following raw materials in parts by weight: 35 parts of Polygonum multiflorum, 35 parts of Sargentodoxa chinensis, 15 parts of Millettia spatholobi, 45 parts of Polygonum multiflorum, 15 parts of Rubia cordifolia, 15 parts of Herba speranskiae radix, 10 parts of Prunella vulgaris leaves, 15 parts of Herba Ligustici amara and 20 parts of Caulis Spatholobi.

[0034] This embodiment also provides a method for preparing the above-mentioned foot bath powder, comprising the following steps:

[0035] (1) The raw materials are cleaned and impurities removed, and then hot-air dried at 50° C. until the moisture content is less than 10%;

[0036] (2) The dried API was crushed into a particle size of 2 mm using a coarse grinder, and then finely crushed into a particle size of 100 mesh using an ultrafine grinder;

[0037] (3) putting the ultrafinely crushed raw materials into a blender and mixing them for 50 minutes to obtain a foot bath powder;

[0038] (4) The mixed foot bath powder is packaged. Before packaging, the mixed foot bath powder is sterilized by cobalt-60 irradiation, with an irradiation dose of 20 kGy.

[0039] Embodiment 2:

[0040] The present embodiment provides a foot bath powder for treating premature ovarian insufficiency, characterized in that the foot bath powder is composed of the following raw materials in parts by weight: 40 parts of Polygonum multiflorum, 40 parts of Sargentodoxa chinensis, 20 parts of Millettia spatholobi, 50 parts of Polygonum multiflorum, 20 parts of Rubia cordifolia, 20 parts of Herba speranskiae radix, 15 parts of Prunella vulgaris leaves, 20 parts of Herba Lycopodii and 20 parts of Caulis Spatholobi.

[0041] This embodiment also provides a method for preparing the above-mentioned foot bath powder, comprising the following steps:

[0042] (1) The raw materials are cleaned and impurities removed, and then hot-air dried at 55° C. until the moisture content is less than 10%;

[0043] (2) The dried API was crushed by a coarse grinder to a particle size of 2.5 mm, and then finely crushed by an ultrafine grinder to a particle size of 150 mesh;

[0044] (3) putting the ultrafinely crushed raw materials into a blender and mixing them for 55 minutes to obtain a foot bath powder;

[0045] (4) The mixed foot bath powder is packaged. Before packaging, the mixed foot bath powder is sterilized by cobalt-60 irradiation, with an irradiation dose of 20 kGy.

[0046] Embodiment 3:

[0047] The present embodiment provides a foot bath powder for treating premature ovarian insufficiency, characterized in that the foot bath powder is composed of the following raw materials in parts by weight: 45 parts of Polygonum multiflorum, 45 parts of Sargentodoxa chinensis, 25 parts of Millettia spatholobi, 55 parts of Polygonum multiflorum, 15-25 parts of Rubia cordifolia, 25 parts of Herba speranskiae radix, 20 parts of Prunella vulgaris leaves, 25 parts of Herba schizonepetae and 25 parts of Caulis scopariae.

[0048] This embodiment also provides a method for preparing the above-mentioned foot bath powder, comprising the following steps:

[0049] (1) The raw materials are cleaned and impurities removed, and then hot-air dried at 60° C. until the moisture content is less than 10%;

[0050] (2) The dried API was crushed into a particle size of 3 mm using a coarse grinder, and then finely crushed into a particle size of 200 mesh using an ultrafine grinder;

[0051] (3) putting the ultrafinely crushed raw materials into a blender and mixing them for 60 minutes to obtain a foot bath powder;

[0052] (4) The mixed foot bath powder is packaged. Before packaging, the mixed foot bath powder is sterilized by cobalt-60 irradiation, with an irradiation dose of 20 kGy.

[0053] In order to illustrate the effect of the foot bath powder of the present application, the applicant collected several groups of typical cases, including cases treated with western medicine and cases treated with the foot bath powder of the present application;

[0054] Case 1: Ms. Huang, 39 years old. She came to our hospital for treatment because of "shortened menstrual cycle accompanied by hot flashes and sweats for half a year, which worsened for 1 week". Before treatment, the FSH value in the follicular phase was 28.5IU / L, the LH value was 26IU / L, the E2 value was 90IU / L, and the Kupperman score was 19 points. She was diagnosed with premature ovarian insufficiency. The patient had a family history of breast cancer and refused hormone replacement therapy. She asked to try foot bath treatment. Subsequently, the doctor prescribed the foot bath powder of this application. After using it for 3 months, the basic FSH value was 25.8IU / L, the LH value was 22.3IU / L, the E2 value was 150IU / L, and the Kupperman score was 9 points. After using it for another 3 months, the FSH value was 18.2U / L, the LH value was 16IU / L, the E2 value was 200IU / L, and the Kupperman score was 3 points. The doctor diagnosed that it was effective.

[0055] Case 2: Ms. Zhou, 38 years old. Pregnant 2 and 1, came to our hospital for treatment due to "small menstrual flow for 3 months". Before treatment, the FSH value in the follicular phase was 25.4IU / L, the LH value was 21.8IU / L, and the E2 value was 100pmol / L. She was diagnosed with premature ovarian insufficiency. She used the foot bath powder of this application to soak her feet. After 3 months of use, the FSH value was 18.2IU / L, the LH value was 12.6IU / L, and the E2 value was 240pmol / L. The menstrual flow was normal, and the doctor judged it to be effective.

[0056] Case 3: Ms. Nong, 39 years old. Pregnancy 0, came to our hospital for treatment because of "no contraception and no pregnancy for 2 years after marriage". Before treatment, the FSH value of the follicular phase was 28.9IU / L, the LH value was 26IU / L, and the E2 value was 89pmol / L. The hospital diagnosed it as premature ovarian insufficiency. After using the foot bath powder of this application for foot bathing, after 6 months, the FSH value was 8.9IU / L, the LH value was 7.8IU / L, and the E2 value was 115pmol / L. After 3 months of follow-up, it was found that she had conceived naturally and finally gave birth to a healthy baby girl.

[0057] Case 4: Ms. Ding, 37 years old. She came to our hospital for treatment because of "oligomenorrhea accompanied by irritability and insomnia for half a year, which worsened for 1 week". Before treatment, the FSH value in the follicular phase was 48.5IU / L, the LH value was 46IU / L, the E2 value was 30pmol / L, and the Kupperman score was 25 points. She was diagnosed with premature ovarian insufficiency. After being introduced by a friend, she used the foot bath powder of this application to soak her feet. After 5 months, the basic FSH value was 24.2IU / L, the LH value was 23IU / L, the E2 value was 100pmol / L, the Kupperman score was 10.0 points, and her sleep was significantly improved.

[0058] The above examples only express several embodiments of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the present invention. It should be pointed out that, for those of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the attached claims.

Claims

1. A foot bath powder for treating premature ovarian insufficiency, characterized in that: The foot bath powder is composed of the following raw materials in parts by weight: 35-45 parts of Polygonum multiflorum, 35-45 parts of Sargentodoxa chinensis, 15-25 parts of Millettia spatholobi, 45-55 parts of Polygonum multiflorum, 15-25 parts of Rubia cordifolia, 15-25 parts of Herba speranskiae radix, 10-20 parts of Prunella vulgaris leaves, 15-25 parts of Herba schizonepetae and 15-25 parts of Caulis gentianae.

2. A foot bath powder for treating premature ovarian insufficiency according to claim 1, characterized in that: The foot bath powder is composed of the following raw materials in parts by weight: 40 parts of Polygonum multiflorum, 40 parts of Sargentodoxae, 20 parts of Millettia reticulata, 50 parts of Polygonum multiflorum, 20 parts of Rubia cordifolia, 20 parts of Herba spermi spermi, 15 parts of Prunus mume, 20 parts of Herba spatholobi, and 20 parts of Caulis spatholobi.

3. A method for preparing a foot bath powder for treating premature ovarian insufficiency according to any one of claims 1-2, characterized in that: The method comprises the following steps: (1) The raw materials are cleaned and impurities removed, and then dried until the moisture content is less than 10%; (2) The dried API is crushed by a coarse grinder to a particle size of 2-3 mm, and then finely crushed by an ultrafine grinder to a particle size of 100-200 mesh; (3) putting the ultrafinely crushed raw materials into a blender and mixing them for 50-60 minutes to obtain a foot bath powder; (4) The mixed foot bath powder is packaged.

4. The method according to claim 3, characterized in that The drying in step (1) is performed by hot air drying at a temperature of 50-60°C.

5. The method according to claim 3, characterized in that: Before packaging, the mixed foot bath powder is sterilized by cobalt-60 irradiation with an irradiation dose of 20 kGy.