Traditional Chinese medicine ointment for conditioning rhinitis and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to traditional Chinese medicine ointment for conditioning rhinitis and a preparation method thereof.The traditional Chinese medicine ointment is prepared from, by mass, 5-12 parts of poria cocos, 10-22 parts of schisandra chinensis, 12-17 parts of platycodon grandiflorum, 3-10 parts of corydalis tuber, 2-5 parts of coptis chinensis, 2-6 parts of camphor and 1-3 parts of borneol. The traditional Chinese medicine ointment provided by the invention can effectively relieve acute rhinitis, and has the advantages of simple treatment procedure, simple prescription, no side effect, no pain of patients and low treatment cost.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine ointment for regulating rhinitis and a preparation method thereof. Background Art

[0002] Acute and chronic rhinitis, allergic rhinitis, and paranasal sinusitis are caused by changes in the permeability of inflammatory cells in the nasal mucosa. Common clinical symptoms include clear and purulent nasal discharge, nasal congestion, dyspnea, and shortness of breath that affect sleep, followed by headaches. In severe cases, symptoms such as paranasal sinusitis and nasal concha hypertrophy develop, which particularly affect children's learning and adults' work efficiency. It is a common disease caused by multiple pathogenic factors.

[0003] In the prior art, surgical treatment can be used, but traditional surgeries such as microwave and laser are often more traumatic, painful for patients, with a long recovery period, and easy bleeding, requiring hospitalization for observation. In addition, the field of view of the nasal endoscope is blurred, and it is difficult to see the structures in the nasal cavity and sinuses during the operation, and it is impossible to accurately locate, which affects the surgical effect. Moreover, the operation can only treat a single disease, and the diseased tissue is easy to remain during the operation, making sinusitis difficult to cure and having a high recurrence rate. In addition, the cost of treatment is relatively high, and the complicated costs of examination, surgery, and hospitalization are a considerable expense for patients.

[0004] In addition, the treatments for rhinitis include antibiotics, antihistamines and traditional Chinese medicine such as Biyankang and Huodan Pills. However, traditional topical drugs such as vasoconstrictor drops have serious side effects, cannot help the nasal mucosa to establish immune function, are highly drug-dependent, and take effect slowly. Moreover, after oral drugs are absorbed by the stomach and intestines, insufficient drugs reach the lesions, resulting in rapid rebound of bactericidal drugs.

[0005] For example, CN118001341B discloses a Chinese medicine composition, ointment and preparation method thereof for treating allergic rhinitis and other allergic diseases caused by low immunity. Specifically, the Chinese medicine composition is composed of the following raw materials: black plum, astragalus, white atractylodes, polygonatum, oxalis, saposhnikovia, bupleurum, cassia twig, white peony root, angelica dahurica, magnolia, fennel, five-fingered peach, ophiopogon, and hawthorn. The Chinese medicine composition provided by the application is prepared into a Chinese medicine preparation, such as a Chinese medicine ointment, which can be used for the treatment of allergic diseases (including allergic rhinitis, chronic rhinitis, chronic sinusitis, allergic conjunctivitis, and allergic cough) caused by low immunity. However, the prescription contains many drugs, and some patients may be allergic to some of the drugs. It may also be due to individual physical differences, such as those with yin deficiency and yang hyperactivity use warming drugs such as astragalus and cassia twig to help heat and generate fire, and those with weak spleen and stomach are difficult to transport and transform greasy drugs such as polygonatum and ophiopogon, which may cause adverse reactions such as abdominal distension and poor appetite. Long-term use may also increase the metabolic burden of the liver and kidneys.

[0006] For example, CN107496656A discloses a new use of a traditional Chinese medicine composition in the treatment of rhinitis and cough, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20-40 parts of camphor, 200-300 parts of methyl salicylate, 80-110 parts of turpentine oil, 200-300 parts of peppermint oil, 10-20 parts of clove basil oil, 100-200 parts of camphor oil, 10-30 parts of star anise oil, 10-30 parts of cinnamon oil, 2-4 parts of borneol, 20-35 parts of menthol, 30-50 parts of eucalyptus oil, and 40-120 parts of tea oil extract. The Chinese medicine composition of this application has a good therapeutic effect on rhinitis and cough. However, when this formula is used to treat rhinitis, ingredients such as camphor, borneol, and menthol have strong pungent properties and may cause excessive stimulation to the nasal mucosa, causing discomfort or damage. In addition, the drugs are highly volatile and have a short duration of action, requiring frequent use. At the same time, multiple oil ingredients may cause allergic reactions in some patients, affecting the safety and effectiveness of the treatment.

[0007] In view of this, the present invention is proposed. Summary of the invention

[0008] The purpose of the present invention is to provide a Chinese medicine ointment for regulating rhinitis and a preparation method thereof. The Chinese medicine ointment provided by the present invention can effectively relieve acute rhinitis, and the treatment procedure is simple, the prescription is simple and has no side effects, the patient does not suffer, and the treatment cost is low.

[0009] In order to achieve the above object, the present invention provides the following technical solutions:

[0010] In the first aspect, an embodiment of the present invention provides a traditional Chinese medicine ointment for regulating rhinitis, which includes the following component raw materials, measured by mass: 5-12 parts of Poria cocos, 10-22 parts of Schisandra chinensis, 12-17 parts of Platycodon grandiflorum, 3-10 parts of Corydalis yanhusuo, 2-5 parts of Coptis chinensis, 2-6 parts of camphor, and 1-3 parts of borneol.

[0011] In a preferred embodiment, the Chinese medicine ointment comprises the following component raw materials in parts by mass: 7-10 parts of Poria cocos, 14-20 parts of Schisandra chinensis, 15-16 parts of Platycodon grandiflorum, 4-8 parts of Corydalis yanhusuo, 3-5 parts of Coptis chinensis, 2-4 parts of camphor, and 2-3 parts of borneol.

[0012] In a preferred embodiment, the Chinese medicine ointment comprises the following component raw materials in parts by mass: 8 parts of Poria cocos, 15 parts of Schisandra chinensis, 16 parts of Platycodon grandiflorum, 5 parts of Corydalis yanhusuo, 3 parts of Coptis chinensis, 3 parts of camphor, and 2 parts of borneol.

[0013] In a preferred embodiment, the Chinese medicine ointment comprises the following component raw materials in parts by mass: 9 parts of Poria cocos, 18 parts of Schisandra chinensis, 16 parts of Platycodon grandiflorum, 7 parts of Corydalis yanhusuo, 5 parts of Coptis chinensis, 4 parts of camphor, and 3 parts of borneol.

[0014] In the Chinese medicine ointment provided by the present invention, Poria cocos can promote diuresis and eliminate dampness, strengthen the spleen and calm the mind, and can relieve nasal mucosal edema and increased secretions; Schisandra chinensis can be astringent, invigorate qi and produce body fluid, inhibit excessive glandular secretion and repair mucosa; Platycodon grandiflorum can promote lung function and eliminate phlegm, discharge pus and relieve throat, and promote the discharge of nasal purulent secretions; Corydalis yanhusuo can promote blood circulation and qi, disperse blood stasis and relieve pain, improve local blood circulation and relieve nasal congestion and headache; Camphor and Borneol are pungent and fragrant, and have the effects of anti-inflammatory and analgesic, opening the orifices and dredging collaterals, can promote drug transdermal absorption and relieve mucosal irritation; Coptis chinensis can clear away heat and dampness, purge fire and detoxify, inhibit bacterial and viral reproduction, and control inflammatory reactions. All medicines work together to play the effects of eliminating dampness and eliminating phlegm, promoting qi and opening the orifices, anti-inflammatory and antibacterial, and repairing mucosa, and comprehensively improve rhinitis symptoms from multiple angles of reducing secretions, unblocking airways, inhibiting pathogens, and relieving pain.

[0015] In a second aspect, the present invention provides a method for preparing the above-mentioned Chinese medicine ointment for treating rhinitis, comprising the following steps:

[0016] (1) Take Poria cocos and add water to boil for 2-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0017] (2) Take Schisandra chinensis and add water to boil for 3-6 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0018] (3) Take Platycodon grandiflorum and add water to boil for 2-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0019] (4) Crush the Corydalis yanhusuo to 200-400 mesh to obtain Corydalis yanhusuo powder, add water to the Corydalis yanhusuo powder and boil for 2-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0020] (5) Take Coptis chinensis and add water to boil for 2-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0021] (6) Take camphor and add water to boil for 3-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0022] (7) The thick pastes obtained in steps (1) to (6) are mixed, and then borneol is added and mixed evenly to obtain a Chinese medicine ointment for treating rhinitis.

[0023] In a preferred embodiment, in step (1), the mass ratio of Poria cocos to water is (8-20): (2000-4000).

[0024] In a preferred embodiment, in step (2), the mass ratio of Schisandra chinensis to water is (15-20): (3000-5000).

[0025] In a preferred embodiment, in step (3), the mass ratio of Platycodon grandiflorum to water is (15-20): (1000-3000).

[0026] In a preferred embodiment, in step (4), the mass ratio of the Corydalis yanhusuo powder to water is (10-20): (2000-3000).

[0027] In a preferred embodiment, in step (5), the mass ratio of Coptidis rhizome to water is (3-10): (2000-3000).

[0028] In a preferred embodiment, in step (6), the mass ratio of camphor to water is (2-10): (2000-3000).

[0029] The traditional Chinese medicine ointment obtained by the invention is directly applied to the nasal cavity lesion once in the morning and evening every day, and the nasal cavity lesion can be healed in 2-4 weeks.

[0030] Compared with the prior art, the advantages and beneficial effects of the present invention are:

[0031] 1. The Chinese medicine ointment provided by the present invention has the advantages of diuresis and dampness elimination, spleen invigoration and heart tranquilization, and can relieve nasal mucosal edema and increased secretions; Schisandrae Chinensis is astringent and astringent, invigorating qi and promoting body fluid, inhibiting excessive glandular secretion and repairing mucosa; Platycodon grandiflorum is purgative and expectorant, pus-discharging and throat-clearing, and promoting the discharge of nasal purulent secretions; Corydalis yanhusuo is activating blood circulation and qi, dispersing blood stasis and relieving pain, improving local blood circulation and relieving nasal congestion and headache; Camphor and Borneol are pungent and fragrant, and have the effects of anti-inflammatory and analgesic, opening the orifices and dredging collaterals, and can promote drug transdermal absorption and relieve mucosal irritation; Coptis chinensis clears away heat and dampness, purges fire and detoxifies, inhibits bacterial and viral reproduction, and controls inflammatory reactions. All the medicines work together to play the effects of removing dampness and phlegm, promoting qi and opening the orifices, anti-inflammatory and antibacterial, and repairing mucosa, and comprehensively improve rhinitis symptoms from multiple angles of reducing secretions, unblocking airways, inhibiting pathogens, and relieving pain.

[0032] 2. The Chinese medicine ointment provided by the present invention has significant efficacy, high cure rate, low recurrence, low treatment cost, minimal pain during the treatment process, and no toxic side effects when treating rhinitis. DETAILED DESCRIPTION

[0033] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0034] Example 1

[0035] This embodiment provides a method for preparing a Chinese medicine ointment for regulating rhinitis, comprising the following steps:

[0036] (1) Take 8 g of Poria cocos and add 3000 ml of water to boil for 4 h, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0037] (2) Take 15g of Schisandra chinensis and add 4000ml of water and boil for 3-6h, filter and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0038] (3) Take 16g of Platycodon grandiflorum and add 2000ml of water and boil for 2-5h, filter and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0039] (4) Grind 10 g of Corydalis yanhusuo to 200-400 mesh to obtain Corydalis yanhusuo powder, add 5 g of Corydalis yanhusuo powder to 2000 ml of water and boil for 2-5 h, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0040] (5) Take 3 g of Coptis chinensis and add 2000 ml of water, boil for 2-5 h, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0041] (6) Take 3g of camphor and add 2000ml of water and boil for 3-5h, filter and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0042] (7) The thick pastes obtained in steps (1) to (6) are mixed, and then 2 g of borneol is added and mixed evenly to obtain a Chinese medicine ointment for treating rhinitis.

[0043] Example 2

[0044] This embodiment provides a method for preparing a Chinese medicine ointment for regulating rhinitis, comprising the following steps:

[0045] (1) Take 9 g of Poria cocos and add 3000 ml of water and boil for 4 h, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0046] (2) Take 18g of Schisandra chinensis and add 4000ml of water and boil for 3-6h, filter and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0047] (3) Take 16g of Platycodon grandiflorum and add 2000ml of water and boil for 2-5h, filter and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0048] (4) Grind 10 g of Corydalis yanhusuo to 200-400 mesh to obtain Corydalis yanhusuo powder, add 7 g of Corydalis yanhusuo powder to 2000 ml of water and boil for 2-5 h, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0049] (5) Take 5 g of Coptis chinensis and add 2000 ml of water to boil for 2-5 h, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0050] (6) Take 4 g of camphor and add 2000 ml of water and boil for 3-5 h, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use;

[0051] (7) The thick pastes obtained in steps (1) to (6) are mixed, and then 3 g of borneol is added and mixed evenly to obtain a Chinese medicine ointment for treating rhinitis.

[0052] Comparative Example 1

[0053] The difference between this comparative example and Example 1 is that no Poria cocos is added.

[0054] Comparative Example 2

[0055] The difference between this comparative example and Example 1 is that no Schisandra chinensis was added.

[0056] Comparative Example 3

[0057] The difference between this comparative example and Example 1 is that Corydalis yanhusuo was not added.

[0058] Comparative Example 4

[0059] The difference between this comparative example and Example 1 is that no coptis root is added.

[0060] Comparative Example 5

[0061] The difference between this comparative example and Example 1 is that no camphor is added.

[0062] Comparative Example 6

[0063] The difference between this comparative example and Example 1 is that no borneol was added.

[0064] Clinical efficacy trials:

[0065] (1) Subjects

[0066] 160 healthy volunteers, aged 20 to 50 years old, with an equal number of males and females, were selected and randomly divided into 8 groups according to the order of enrollment, namely, the embodiment and the comparative example, with an equal number of males and females in each group.

[0067] (2) Diagnostic criteria

[0068] With reference to Traditional Chinese Medicine Otorhinolaryngology and General Principles of Clinical Research on New Chinese Medicines and combined with clinical practice, the medical record diagnosed acute rhinitis.

[0069] (3) Inclusion and exclusion criteria:

[0070] Inclusion criteria: Anyone who meets the laboratory test indicators and has more than two main symptoms and a group of concomitant symptoms can be used as an observation subject; aged between 20-50 years old; informed consent, voluntary participation.

[0071] Exclusion criteria: patients with other diseases, syndromes or complications that may affect the diagnosis and efficacy judgment of the target indication; patients who have received relevant treatments that may affect the evaluation of effectiveness and safety indicators; patients with other physiological or pathological conditions that may affect the observation and judgment of efficacy and safety indicators, such as menstruation, or patients with serious primary diseases of the heart, brain, liver, kidney and hematopoietic system; certain groups that may be at high risk, such as pregnant women, minors, elderly patients, those with allergic constitutions or a history of adverse reactions to the test drug or its ingredients, those with critical conditions and the possibility of accidents, or patients with advanced diseases. Unless it is necessary for the purpose of clinical trials.

[0072] (4) Treatment method: directly apply the Chinese medicine ointment of the embodiment and comparative example to the nasal lesion, once in the morning and evening, 2 g each time, for 3 weeks.

[0073] (5) During the trial, the subjects did not experience abnormal symptoms and were evaluated using a rhinitis scoring table. The specific scoring table is shown in Table 1, and the effects after treatment are shown in Table 2.

[0074] Table 1

[0075] Recovery Points Daytime cough symptom score get well 0 Clear nasal discharge, nasal itching and burning disappeared; sinusitis and headache disappeared Improvement 1 Clear nasal discharge disappears, nasal itching is relieved, and headache disappears Slightly improved 2 Clear nasal discharge disappeared more often, nasal itching was relieved more often, and the number of headaches decreased Not cured 3 No change in symptoms

[0076] Table 2

[0077]

[0078]

[0079] It can be seen from the above performance test results that the Chinese medicine ointments prepared in Example 1 and Example 2 can effectively relieve acute rhinitis, and the treatment procedure is simple, the patient does not suffer, and the treatment cost is low.

[0080] The comparative example does not adopt the necessary technical solution, resulting in its performance being significantly worse than that of the embodiment in the corresponding performance test. This better proves the irreplaceable nature of the specific technical solution of the present application in achieving technical effects and solving technical problems.

[0081] The above is a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine ointment for treating rhinitis, characterized in that: The composition comprises the following raw materials by weight: 5-12 parts of Poria cocos, 10-22 parts of Schisandra chinensis, 12-17 parts of Platycodon grandiflorum, 3-10 parts of Corydalis yanhusuo, 2-5 parts of Coptis chinensis, 2-6 parts of camphor and 1-3 parts of borneol.

2. The Chinese medicinal ointment for treating rhinitis according to claim 1, characterized in that: The Chinese medicine ointment comprises the following raw materials by weight: 7-10 parts of Poria cocos, 14-20 parts of Schisandra chinensis, 15-16 parts of Platycodon grandiflorum, 4-8 parts of Corydalis yanhusuo, 2-4 parts of camphor, 3-5 parts of Coptis chinensis, and 2-3 parts of borneol.

3. The Chinese medicinal ointment for treating rhinitis according to claim 1 or 2, characterized in that: The Chinese medicine ointment comprises the following raw materials by weight: 8 parts of Poria cocos, 15 parts of Schisandra chinensis, 16 parts of Platycodon grandiflorum, 5 parts of Corydalis yanhusuo, 3 parts of Coptis chinensis, 3 parts of Camphor and 2 parts of Borneol.

4. The Chinese medicinal ointment for treating rhinitis according to claim 1, 2 or 3, characterized in that: The Chinese medicine ointment comprises the following raw materials by weight: 9 parts of Poria cocos, 18 parts of Schisandra chinensis, 16 parts of Platycodon grandiflorum, 7 parts of Corydalis yanhusuo, 5 parts of Coptis chinensis, 4 parts of camphor and 3 parts of borneol.

5. A method for preparing a Chinese medicinal ointment for treating rhinitis according to any one of claims 1 to 4, characterized in that: The following steps are involved: (1) Take Poria cocos and add water to boil for 2-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use; (2) Take Schisandra chinensis and add water to boil for 3-6 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use; (3) Take Platycodon grandiflorum and add water to boil for 2-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use; (4) Crush the Corydalis yanhusuo to 200-400 mesh to obtain Corydalis yanhusuo powder, add water to the Corydalis yanhusuo powder and boil for 2-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use; (5) Take Coptis chinensis and add water to boil for 2-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use; (6) Take camphor and add water to boil for 3-5 hours, filter, and concentrate to a thick paste with a relative density of 1.2-1.35 for later use; (7) The thick pastes obtained in steps (1) to (6) are mixed, and then borneol is added and mixed evenly to obtain a Chinese medicine ointment for treating rhinitis.

6. The method for preparing the Chinese medicinal ointment for treating rhinitis according to claim 5, characterized in that: In step (1), the mass ratio of Poria cocos to water is (8-20): (2000-4000).

7. The method for preparing the Chinese medicinal ointment for treating rhinitis according to claim 5, characterized in that: In step (2), the mass ratio of Schisandra chinensis to water is (15-20): (3000-5000).

8. The method for preparing the Chinese medicinal ointment for treating rhinitis according to claim 5, characterized in that: In step (3), the mass ratio of Platycodon grandiflorum to water is (15-20): (1000-3000).

9. The method for preparing the Chinese medicinal ointment for treating rhinitis according to claim 5, characterized in that: In step (4), the mass ratio of the Corydalis yanhusuo powder to water is (10-20): (2000-3000).

10. The method for preparing the Chinese medicinal ointment for treating rhinitis according to claim 5, characterized in that: In step (5), the mass ratio of coptis root and water is (3-10): (2000-3000); In step (6), the mass ratio of camphor to water is (2-10): (2000-3000).

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