Ointment for treating oral ulcer and preparation method thereof

Abstract

The invention provides an ointment for treating oral ulcer and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 4 to 7 parts of rhizoma coptidis, 8 to 12 parts of flos lonicerae, 4 to 6 parts of radix glycyrrhizae, 3 to 7 parts of radix scutellariae, 2 to 5 parts of borneol, 2 to 5 parts of herba menthae, 5 to 10 parts of radix rehmanniae, 4 to 9 parts of radix scrophulariae, 5 to 9 parts of herba taraxaci, 10 to 14 parts of radix isatidis, 2 to 5 parts of tea tree oil, 1 to 4 parts of propolis extract, 1 to 4 parts of curcumin, 2 to 5 parts of flos caryophylli, 0.5 to 0.8 part of lidocaine, 0.1 to 0.3 part of chlorhexidine, 0.1 to 0.3 part of hydrocortisone and 0.5 to 0.8 part of vitamin B group. Various traditional Chinese medicinal materials are added into the ointment, so that the ointment has the effects of resisting bacteria, diminishing inflammation, relieving pain, promoting healing, freshening breath and enhancing immunity, meanwhile, lidocaine, chlorhexidine, hydrocortisone and vitamin B are also added into the ointment, so that Chinese and western medicines are combined, the advantages of the traditional Chinese medicines and western medicines are integrated, symptoms can be quickly relieved, and the ointment has the advantages of being free of toxic and side effects and free of toxic and side effects. And the traditional Chinese medicine composition has few side effects and is suitable for long-term use.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of oral ulcer ointment, in particular to an ointment for treating oral ulcer and a preparation method thereof. Background Art

[0002] Oral ulcers, also known as "mouth sores", are a common oral mucosal disease that often appears on the mucosa of the lips, palate, tongue and cheeks in the mouth. They are round or oval painful ulcers. A variety of factors such as genetics, diet, and decreased immunity may induce oral ulcers, which vary greatly from person to person. About 10% to 25% of the population in my country suffers from recurrent oral ulcers, which are common in people aged 10 to 30 years old. The prevalence rate in women is higher than that in men. Oral ulcers can appear on the mucosa of the lips, cheeks, soft palate or gums in the mouth. The ulcer surface is round or oval, with a white or yellow center, and the surrounding area is slightly red and swollen, accompanied by a clear sense of pain.

[0003] The treatment measures for oral ulcers are mainly local anti-inflammatory, pain relief, and promotion of ulcer healing. Systemic treatment is mostly to extend the interval period. Treatment is based on the severity of the ulcer and the patient's wishes. The main methods include local drug therapy, systemic drug therapy, and physical therapy. Laser irradiation can help mucosal regeneration, reduce inflammatory response, and promote ulcer healing.

[0004] In recent years, some Chinese herbal compound medicines have appeared in this field for treating this disease according to the principle of clearing the stomach and purging the spleen in traditional Chinese medicine, such as Kouyanqing Capsules, Koukoukueiling Capsules, Huanglian Shangqing Pills, Sanlian Tablets, etc. Although the above-mentioned medicines have certain therapeutic effects on the treatment of oral ulcers in some aspects, in general, the clinical cure rate of these medicines is low, the recurrence rate is extremely high, and they cannot cure the root cause. In addition, some drugs have toxic side effects on patients. Summary of the invention

[0005] 1. Technical issues to be resolved

[0006] In view of the deficiencies in the prior art, the present invention provides an ointment for treating oral ulcers and a preparation method thereof, which solves the problem that although the existing drugs have certain therapeutic effects on the treatment of oral ulcers in some aspects, generally speaking, these drugs have a low clinical cure rate, a very high recurrence rate, and cannot cure the root cause.

[0007] (II) Technical solution

[0008] To achieve the above objectives, the present invention is implemented through the following technical scheme: an ointment for treating oral ulcers, composed of the following raw materials in parts by weight: 4-7 parts of coptis root, 8-12 parts of honeysuckle, 4-6 parts of liquorice, 3-7 parts of scutellaria, 2-5 parts of borneol, 2-5 parts of mint, 5-10 parts of rehmannia root, 4-9 parts of scrophularia, 5-9 parts of dandelion, 10-14 parts of isatis root, 2-5 parts of tea tree oil, 1-4 parts of propolis extract, 1-4 parts of curcumin, 2-5 parts of cloves, 0.5-0.8 parts of lidocaine, 0.1-0.3 parts of chlorhexidine, 0.1-0.3 parts of hydrocortisone, 0.5-0.8 parts of vitamin B group, and 0.08-0.1 parts of alcohol.

[0009] Preferably, the composition is composed of the following raw materials in parts by weight: 4 parts of coptis chinensis, 8 parts of honeysuckle, 4 parts of licorice, 3 parts of scutellaria baicalensis, 2 parts of borneol, 2 parts of mint, 5 parts of raw rehmannia, 4 parts of scrophulariae, 5 parts of dandelions, 10 parts of isatis root, 2 parts of tea tree oil, 1 part of propolis extract, 1 part of curcumin, 2 parts of cloves, 0.5 parts of lidocaine, 0.1 parts of chlorhexidine, 0.1 parts of hydrocortisone, 0.5 parts of vitamin B group, and 0.08 parts of alcohol.

[0010] A method for preparing an ointment for treating oral ulcers comprises the following preparation steps:

[0011] S1, add coptis root, honeysuckle, liquorice, scutellaria, borneol, mint, raw rehmannia, figwort, dandelion, isatis root, tea tree oil, propolis extract, curcumin, and clove into a stirring container and stir for 5-10 minutes, gradually add deionized water during the stirring process, and heat the stirring container until the temperature is 30-40°C, maintain the temperature of the stirring container, and soak for 12-13 hours to form a mixture of the first;

[0012] S2, add lidocaine, chlorhexidine, hydrocortisone, vitamin B group, and alcohol to the mixture, continue stirring, and add a solubilizer, a preservative, and a flavoring agent during the stirring process, and stir for 4-8 minutes to obtain a second mixture;

[0013] S3, filtering the mixture 2 to remove internal impurities;

[0014] S4. Use a homogenizer or a high-speed stirrer to homogenize the mixture 1 and the mixture 2 to ensure that the ointment is fine and uniform, pour the uniformly mixed ointment into a clean container, and allow it to cool and solidify naturally;

[0015] S5. Pack the ointment into appropriate packaging containers, such as aluminum tubes or plastic boxes, and label the packaging with the product name, ingredients, directions for use, production date and expiration date.

[0016] Preferably, the solubilizer in S2 is 5% glycerol, the preservative is 0.1% sodium benzoate, and the flavoring agent is 0.05 peppermint oil.

[0017] Preferably, the filter component used in S3 is a microporous filter membrane.

[0018] (III) Beneficial effects

[0019] The present invention provides an ointment for treating oral ulcers and a preparation method thereof, which has the following beneficial effects:

[0020] 1. The present invention adds a variety of Chinese medicinal materials into the ointment to make it have antibacterial and anti-inflammatory effects, relieve pain and promote healing, freshen breath and increase immunity. At the same time, lidocaine, chlorhexidine, hydrocortisone and vitamin B group are also added to the ointment, so that it combines Chinese and Western medicines and combines the advantages of Chinese and Western medicines. It can quickly relieve symptoms and promote long-term healing, and has fewer side effects, so it is suitable for long-term use. DETAILED DESCRIPTION

[0021] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0022] Embodiment 1:

[0023] The embodiment of the present invention provides an ointment for treating oral ulcers, which is composed of the following raw materials in parts by weight: 4 parts of coptis root, 8 parts of honeysuckle, 4 parts of liquorice, 3 parts of scutellaria, 2 parts of borneol, 2 parts of mint, 5 parts of raw rehmannia, 4 parts of scrophularia, 5 parts of dandelion, 10 parts of isatis root, 2 parts of tea tree oil, 1 part of propolis extract, 1 part of curcumin, 2 parts of cloves, 0.5 parts of lidocaine, 0.1 parts of chlorhexidine, 0.1 parts of hydrocortisone, 0.5 parts of vitamin B group, and 0.08 parts of alcohol.

[0024] A method for preparing an ointment for treating oral ulcers comprises the following preparation steps:

[0025] S1, add coptis root, honeysuckle, liquorice, scutellaria, borneol, mint, raw rehmannia, figwort, dandelion, isatis root, tea tree oil, propolis extract, curcumin, and clove into a stirring container and stir for 5-10 minutes, gradually add deionized water during the stirring process, and heat the stirring container until the temperature is 30-40°C, maintain the temperature of the stirring container, and soak for 12-13 hours to form a mixture of the first;

[0026] S2, add lidocaine, chlorhexidine, hydrocortisone, vitamin B group, and alcohol to the mixture, continue stirring, and add a solubilizer, a preservative, and a flavoring agent during the stirring process, and stir for 4-8 minutes to obtain a second mixture;

[0027] S3, filtering the mixture 2 to remove internal impurities;

[0028] S4. Use a homogenizer or a high-speed stirrer to homogenize the mixture 1 and the mixture 2 to ensure that the ointment is fine and uniform, pour the uniformly mixed ointment into a clean container, and allow it to cool and solidify naturally;

[0029] S5. Pack the ointment into appropriate packaging containers, such as aluminum tubes or plastic boxes, and label the packaging with the product name, ingredients, directions for use, production date and expiration date.

[0030] The solubilizer in S2 is 5% glycerol, the preservative is 0.1% sodium benzoate, and the flavoring agent is 0.05 peppermint oil.

[0031] The filter element used in S3 is a microporous filter membrane.

[0032] Embodiment 2:

[0033] The embodiment of the present invention provides an ointment for treating oral ulcers, which is composed of the following raw materials in parts by weight: 5 parts of coptis root, 10 parts of honeysuckle, 5 parts of liquorice, 5 parts of scutellaria, 3 parts of borneol, 4 parts of mint, 7 parts of rehmannia root, 7 parts of figwort, 8 parts of dandelion, 11 parts of isatis root, 4 parts of tea tree oil, 2 parts of propolis extract, 2 parts of curcumin, 3 parts of cloves, 0.6 parts of lidocaine, 0.12 parts of chlorhexidine, 0.2 parts of hydrocortisone, 0.7 parts of vitamin B group, and 0.09 parts of alcohol.

[0034] A method for preparing an ointment for treating oral ulcers comprises the following preparation steps:

[0035] S1, add coptis root, honeysuckle, liquorice, scutellaria, borneol, mint, raw rehmannia, figwort, dandelion, isatis root, tea tree oil, propolis extract, curcumin, and clove into a stirring container and stir for 5-10 minutes, gradually add deionized water during the stirring process, and heat the stirring container until the temperature is 30-40°C, maintain the temperature of the stirring container, and soak for 12-13 hours to form a mixture of the first;

[0036] S2, add lidocaine, chlorhexidine, hydrocortisone, vitamin B group, and alcohol to the mixture, continue stirring, and add a solubilizer, a preservative, and a flavoring agent during the stirring process, and stir for 4-8 minutes to obtain a second mixture;

[0037] S3, filtering the mixture 2 to remove internal impurities;

[0038] S4. Use a homogenizer or a high-speed stirrer to homogenize the mixture 1 and the mixture 2 to ensure that the ointment is fine and uniform, pour the uniformly mixed ointment into a clean container, and allow it to cool and solidify naturally;

[0039] S5. Pack the ointment into appropriate packaging containers, such as aluminum tubes or plastic boxes, and label the packaging with the product name, ingredients, directions for use, production date and expiration date.

[0040] The solubilizer in S2 is 5% glycerol, the preservative is 0.1% sodium benzoate, and the flavoring agent is 0.05 peppermint oil.

[0041] The filter element used in S3 is a microporous filter membrane.

[0042] Embodiment 3:

[0043] The embodiment of the present invention provides an ointment for treating oral ulcers, which is composed of the following raw materials in parts by weight: 7 parts of coptis root, 12 parts of honeysuckle, 6 parts of liquorice, 7 parts of scutellaria, 5 parts of borneol, 5 parts of mint, 10 parts of rehmannia root, 9 parts of figwort, 9 parts of dandelion, 14 parts of isatis root, 5 parts of tea tree oil, 4 parts of propolis extract, 4 parts of curcumin, 5 parts of cloves, 0.8 parts of lidocaine, 0.3 parts of chlorhexidine, 0.3 parts of hydrocortisone, 0.8 parts of vitamin B group, and 0.1 parts of alcohol.

[0044] A method for preparing an ointment for treating oral ulcers comprises the following preparation steps:

[0045] S1, add coptis root, honeysuckle, liquorice, scutellaria, borneol, mint, raw rehmannia, figwort, dandelion, isatis root, tea tree oil, propolis extract, curcumin, and clove into a stirring container and stir for 5-10 minutes, gradually add deionized water during the stirring process, and heat the stirring container until the temperature is 30-40°C, maintain the temperature of the stirring container, and soak for 12-13 hours to form a mixture of the first;

[0046] S2, add lidocaine, chlorhexidine, hydrocortisone, vitamin B group, and alcohol to the mixture, continue stirring, and add a solubilizer, a preservative, and a flavoring agent during the stirring process, and stir for 4-8 minutes to obtain a second mixture;

[0047] S3, filtering the mixture 2 to remove internal impurities;

[0048] S4. Use a homogenizer or a high-speed stirrer to homogenize the mixture 1 and the mixture 2 to ensure that the ointment is fine and uniform, pour the uniformly mixed ointment into a clean container, and allow it to cool and solidify naturally;

[0049] S5. Pack the ointment into appropriate packaging containers, such as aluminum tubes or plastic boxes, and label the packaging with the product name, ingredients, directions for use, production date and expiration date.

[0050] The solubilizer in S2 is 5% glycerol, the preservative is 0.1% sodium benzoate, and the flavoring agent is 0.05 peppermint oil.

[0051] The filter element used in S3 is a microporous filter membrane.

[0052] Real-time example 4:

[0053] The embodiment of the present invention provides an ointment for treating oral ulcers, which is composed of the following raw materials in parts by weight: 4-7 parts of coptis root, 8-12 parts of honeysuckle, 4-6 parts of liquorice, 3-7 parts of scutellaria baicalensis, 2-5 parts of borneol, 2-5 parts of mint, 5-10 parts of rehmannia root, 4-9 parts of figwort, 5-9 parts of dandelion, 10-14 parts of isatis root, 2-5 parts of tea tree oil, 1-4 parts of propolis extract, 1-4 parts of curcumin, and 2-5 parts of cloves.

[0054] A method for preparing an ointment for treating oral ulcers comprises the following preparation steps:

[0055] S1, add coptis root, honeysuckle, liquorice, scutellaria, borneol, mint, raw rehmannia, figwort, dandelion, isatis root, tea tree oil, propolis extract, curcumin, and clove into a stirring container and stir for 5-10 minutes, gradually add deionized water during the stirring process, and heat the stirring container until the temperature is 30-40°C, maintain the temperature of the stirring container, and soak for 12-13 hours to form a mixture of the first;

[0056] S2, adding a solubilizer, a preservative and a flavoring agent to the mixture 1, and stirring for 4-8 minutes to obtain a mixture 2;

[0057] S3, filtering the mixture 2 to remove internal impurities;

[0058] S4. Use a homogenizer or a high-speed stirrer to homogenize the mixture 1 and the mixture 2 to ensure that the ointment is fine and uniform, pour the uniformly mixed ointment into a clean container, and allow it to cool and solidify naturally;

[0059] S5. Pack the ointment into appropriate packaging containers, such as aluminum tubes or plastic boxes, and label the packaging with the product name, ingredients, directions for use, production date and expiration date.

[0060] The solubilizer in S2 is 5% glycerol, the preservative is 0.1% sodium benzoate, and the flavoring agent is 0.05 peppermint oil.

[0061] The filter element used in S3 is a microporous filter membrane.

[0062] Embodiment 5:

[0063] In order to intuitively demonstrate the use effect of the oral ulcer ointment prepared in the present invention, 150 eligible oral ulcer patients were selected, and their baseline data (ulcer size, pain score, etc.) were recorded. They were randomly divided into five groups of 30 people each, and were given oral ulcer ointments commonly available on the market and oral ulcer ointments prepared in Examples 1-4 of the present invention. After the 7th day of use, the evaluation was performed. The specific experimental results are shown in the following table;

[0064] Ordinary ointment Embodiment 1 Embodiment 2 Embodiment 3 Embodiment 4 No effect 3％ 0％ 0％ 0％ 0％ Ulcers still present 90％ 30％ 14％ 23％ 44％ Completely improved 7％ 70％ 86％ 77％ 66％

[0065] In summary, the oral ulcers prepared by the present invention have a significant improvement rate compared to the common ointments on the market, so that the complete improvement rate is stabilized between 70-86%, and the preparation method combining Chinese and Western medicine in Examples 1-3 of the present invention has better effect 1 than the ointment prepared by using Chinese medicine alone, and its improvement rate is higher.

[0066] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An ointment for treating oral ulcers, characterized in that: The invention is composed of the following raw materials in parts by weight: 4-7 parts of coptis root, 8-12 parts of honeysuckle, 4-6 parts of liquorice, 3-7 parts of scutellaria, 2-5 parts of borneol, 2-5 parts of mint, 5-10 parts of rehmannia root, 4-9 parts of figwort, 5-9 parts of dandelion, 10-14 parts of isatis root, 2-5 parts of tea tree oil, 1-4 parts of propolis extract, 1-4 parts of curcumin, 2-5 parts of cloves, 0.5-0.8 parts of lidocaine, 0.1-0.3 parts of chlorhexidine, 0.1-0.3 parts of hydrocortisone, 0.5-0.8 parts of vitamin B group and 0.08-0.1 parts of alcohol.

2. The ointment for treating oral ulcer according to claim 1, characterized in that: The preparation method is counted in parts by mass and is composed of the following raw materials in parts by weight: 4 parts of Coptidis Rhizoma, 8 parts of Honeysuckle, 4 parts of Licorice, 3 parts of Scutellaria Baicalensis, 2 parts of Borneolum, 2 parts of Menthol, 5 parts of Rehmannia glutinosa, 4 parts of Scrophularia ningpoensis, 5 parts of Taraxacum officinale, 10 parts of Isatis indigotica, 2 parts of Tea Tree Oil, 1 part of Propolis Extract, 1 part of Curcumin, 2 parts of Cloves, 0.5 parts of Lidocaine, 0.1 parts of Chlorhexidine, 0.1 parts of Hydrocortisone, 0.5 parts of Vitamin B Complex, and 0.08 parts of Alcohol.

3. A method for preparing an ointment for treating oral ulcers, characterized in that: The method comprises the following preparation steps: S1, add coptis root, honeysuckle, liquorice, scutellaria, borneol, mint, raw rehmannia, figwort, dandelion, isatis root, tea tree oil, propolis extract, curcumin, and clove into a stirring container and stir for 5-10 minutes, gradually add deionized water during the stirring process, and heat the stirring container until the temperature is 30-40°C, maintain the temperature of the stirring container, and soak for 12-13 hours to form a mixture of the first; S2, add lidocaine, chlorhexidine, hydrocortisone, vitamin B group, and alcohol to the mixture, continue stirring, and add a solubilizer, a preservative, and a flavoring agent during the stirring process, and stir for 4-8 minutes to obtain a second mixture; S3, filtering the mixture 2 to remove internal impurities; S4. Use a homogenizer or a high-speed stirrer to homogenize the mixture 1 and the mixture 2 to ensure that the ointment is fine and uniform, pour the uniformly mixed ointment into a clean container, and allow it to cool and solidify naturally; S5. Pack the ointment into appropriate packaging containers, such as aluminum tubes or plastic boxes, and label the packaging with the product name, ingredients, directions for use, production date and expiration date.

4. A method for preparing a medicinal ointment for treating oral ulcers according to claim 3, characterized in that: The solubilizer in S2 is 5% glycerol, the preservative is 0.1% sodium benzoate, and the flavoring agent is 0.05 peppermint oil.

5. A method for preparing a medicinal ointment for treating oral ulcers according to claim 3, characterized in that: The filtering component used in S3 is a microporous filter membrane.