Traditional Chinese medicine composition for tonifying qi and blood and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for tonifying qi and blood, and relates to the field of traditional Chinese medicine compositions. Comprising a capsule wall material and a capsule core material, the capsule core material comprises the following raw materials in percentage by mass: 5-8% of prepared rehmannia root oil, 10-15% of Chinese wolfberry fruit oil, 1-2% of yellow essential oil, 15-20% of Chinese chive seed oil, 30-35% of peony seed oil, 1-5% of chrysalis oil, 15-20% of cistanche oil, 1-5% of black sesame oil and 1-5% of walnut oil. The raw materials are homologous in food and food, and the composition has the effects of tonifying yin and yang, tonifying qi and blood, tonifying kidney and strengthening essence, and nourishing yin and tonifying yang.

Description

Technical Field

[0001] The present invention relates to the field of Chinese medicine compositions, and in particular to a Chinese medicine composition for replenishing both qi and blood and a preparation method thereof. Background Art

[0002] In the theoretical system of traditional Chinese medicine, replenishing both qi and blood and nourishing the kidney and replenishing essence are the core principles for treating debilitating diseases, while the concept of balancing and regulating yin and yang runs through the prevention and treatment of chronic diseases and sub-health conditions. Currently, commonly used clinical prescriptions such as Shiquan Dabu Decoction, Liuwei Dihuang Pills, and Jinkui Shenqi Pills have certain therapeutic effects, but modern clinical application has verified that there are still some defects:

[0003] Traditional prescriptions often focus on a single tonic direction (such as Sijunzi Decoction focuses on replenishing qi, and Siwu Decoction focuses on replenishing blood), and effective ingredients are prone to antagonism when combined. For example, a study in the Chinese Journal of Experimental Traditional Chinese Medicine Formulae (2021) showed that although the 5:1 ratio of astragalus to angelica in Danggui Buxue Decoction increased erythropoiesis, it inhibited lymphocyte proliferation activity. The dissolution rate of large molecular polysaccharides and saponins is insufficient due to the traditional water decoction process. For example, the loss rate of ginsenoside Rg1 in conventional extraction is more than 37%, and fat-soluble components (such as ferulic acid) are difficult to form stable complexes with water-soluble carriers, and the oral bioavailability is generally less than 15%. Some prescriptions also have the problem of accumulation of ingredients caused by repeated tonics, such as the superposition of anthraquinones when Rehmannia glutinosa and Polygonum multiflorum are used together, and clinical cases of abnormal liver function have occurred.

[0004] Therefore, there is an urgent need to provide a Chinese medicine composition that has the functions of replenishing both qi and blood, nourishing yin and tonifying yang, and having no toxic side effects. Summary of the invention

[0005] The purpose of the present invention is to provide a Chinese medicine composition for replenishing both qi and blood, wherein all raw materials are of the same origin as medicine and food, and the composition has the effects of replenishing both yin and yang, replenishing both qi and blood, replenishing the kidney and benefiting essence, and nourishing yin and tonifying yang.

[0006] Another object of the present invention is to provide a method for preparing a Chinese medicine composition for replenishing both qi and blood, and microencapsulating polygonatum odoratum oil, leek seed oil and walnut oil with poor stability can improve the stability of the Chinese medicine composition.

[0007] The present invention solves the technical problem by adopting the following technical solutions.

[0008] On the one hand, an embodiment of the present invention provides a traditional Chinese medicine composition for replenishing both qi and blood, comprising a capsule wall material and a capsule core material; the capsule core material comprises the following raw materials by mass percentage:

[0009] Rehmannia oil 5-8%, wolfberry oil 10-15%, polygonatum oil 1-2%, leek seed oil 15-20%, peony seed oil 30-35%, silkworm pupa oil 1-5%, Cistanche oil 15-20%, black sesame oil 1-5%, walnut oil 1-5%.

[0010] In some embodiments of the present invention, the capsule core material comprises the following raw materials by mass percentage:

[0011] Rehmannia oil 5%, wolfberry oil 15%, polygonatum oil 2%, leek seed oil 20%, peony seed oil 30%, silkworm pupa oil 3%, Cistanche oil 20%, black sesame oil 3%, walnut oil 2%.

[0012] In some embodiments of the present invention, the capsule core material comprises the following raw materials by mass percentage:

[0013] Rehmannia oil 8%, wolfberry oil 10%, polygonatum oil 2%, leek seed oil 15%, peony seed oil 35%, silkworm pupa oil 5%, Cistanche oil 15%, black sesame oil 5%, walnut oil 5%.

[0014] In some embodiments of the present invention, the cooked rehmannia butter is obtained by extraction using cooked rehmannia root as raw material and supercritical carbon dioxide as solvent.

[0015] In some embodiments of the present invention, wolfberry oil is prepared by the following method:

[0016] The wolfberry fruit is dried, crushed, and put into an extraction kettle with an extractant at a solid-liquid ratio of 1:10-1:20; continuous extraction is carried out in the extraction reaction kettle, and the extraction is performed 15-20 times within 10-15 minutes; the separation pressure of the continuous extraction is 0.10-1.95MPa, and the separation temperature is 10-90°C; the extract is collected, and after the extract is allowed to stand at room temperature for 60-90 minutes, the extractant is removed to obtain wolfberry oil.

[0017] In some embodiments of the present invention, silkworm chrysalis oil is prepared by the following method:

[0018] The silkworm pupae are cleaned, dried and crushed; the crushed silkworm pupae are mixed with petroleum ether at a ratio of 1: (2-5) g / ml, subjected to ultrasonic reflux extraction, vacuum filtration to obtain oil, and vacuum distillation to obtain silkworm pupa oil.

[0019] In some embodiments of the present invention, the Cistanche deserticola oil is prepared by the following method:

[0020] Drying and crushing the Cistanche deserticola, then putting the Cistanche deserticola powder into an extraction kettle, extracting with supercritical carbon dioxide at 30-40°C and 20-30MPa for 2-4 hours, and collecting the extract;

[0021] Activated carbon decolorization and high temperature deodorization are used to obtain Cistanche deserticola oil.

[0022] In some embodiments of the present invention, yellow essential oil is prepared by the following method:

[0023] The steamed polygonatum is crushed, and then added into 80% ethanol aqueous solution, refluxed for extraction, and the extracts obtained by multiple reflux extractions are combined, filtered, and concentrated under reduced pressure to a water content of less than 5%, thereby obtaining polygonatum oil.

[0024] On the other hand, an embodiment of the present invention provides a method for preparing a Chinese medicine composition for replenishing both qi and blood, characterized in that it comprises:

[0025] S1: Mix cyclodextrin and water and stir evenly; add polygonatum oil, leek seed oil and walnut oil, stir for 1-2 hours, and freeze-dry to obtain microcapsule powder;

[0026] S2: uniformly mix the microcapsule powder with the remaining raw materials and put them into capsules to obtain a Chinese medicine composition.

[0027] In some embodiments of the present invention, the ratio of cyclodextrin to the total mass of polygonatum odoratum oil, leek seed oil and walnut oil is 1:(10-15).

[0028] Compared with the prior art, the embodiments of the present invention have at least the following advantages or beneficial effects:

[0029] Rehmannia glutinosa butter contains polysaccharides, iridoid glycosides and other ingredients, which have the effects of nourishing the liver and kidney, improving soreness of the waist and knees, dizziness and tinnitus. Lycium barbarum oil is rich in linoleic acid, linolenic acid and lycium barbarum polysaccharides, which can help relieve blurred vision and soreness of the waist and knees caused by liver and kidney yin deficiency, and has the effect of nourishing the liver and kidney. Polygonatum odoratum oil has the effects of nourishing qi and yin, strengthening the spleen and moistening the lungs, nourishing essence and kidney, and enhancing immunity. Leek seed oil has many effects such as promoting blood circulation, regulating blood lipids, nourishing the kidney and strengthening yang, promoting digestion, anti-oxidation, anti-bacterial and anti-inflammatory. Peony seed oil has the effects of lowering blood pressure and blood lipids, delaying aging, enhancing immunity, anti-oxidation, and protecting cardiovascular. Silkworm pupa oil has the effects of lowering lipids and cholesterol, lowering blood pressure, nourishing the myocardium, preventing cardiovascular and cerebrovascular diseases, anti-oxidation, anti-aging, and enhancing immunity. Cistanche oil has the effects of nourishing the kidney and essence, moistening the intestines and laxatives, enhancing immunity, anti-fatigue, regulating endocrine and anti-aging. Black sesame oil has multiple functions such as anti-oxidation, laxative, liver and kidney nourishing, black hair and beauty, improving skin elasticity, regulating blood lipids, enhancing immunity and preventing cardiovascular diseases. Walnut oil has the functions of lowering cholesterol, laxative, anti-oxidation, anti-inflammatory, enhancing immunity and promoting calcium absorption. The raw materials are synergistic, and the medicine and food have the same origin. The composition has the functions of tonifying both yin and yang, qi and blood, tonifying the kidney and essence, and nourishing yin and yang.

[0030] The preparation method provided by the invention firstly micro-encapsulates polygonatum oil, leek seed oil and walnut oil with poor stability, thereby improving the stability of the traditional Chinese medicine composition. DETAILED DESCRIPTION

[0031] In order to make the purpose, technical scheme and advantages of the embodiments of the present invention clearer, the technical scheme in the embodiments of the present invention will be described clearly and completely below. If the specific conditions are not specified in the embodiments, they are carried out according to conventional conditions or conditions recommended by the manufacturer. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased commercially.

[0032] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other. The present invention will be described in detail below with reference to specific embodiments.

[0033] The embodiment of the present invention provides a traditional Chinese medicine composition for replenishing both qi and blood, comprising a capsule wall material and a capsule core material; the capsule core material comprises the following raw materials by mass percentage:

[0034] Rehmannia oil 5-8%, wolfberry oil 10-15%, polygonatum oil 1-2%, leek seed oil 15-20%, peony seed oil 30-35%, silkworm pupa oil 1-5%, Cistanche oil 15-20%, black sesame oil 1-5%, walnut oil 1-5%.

[0035] Preferably, the capsule core material comprises the following raw materials by mass percentage:

[0036] Rehmannia oil 5%, wolfberry oil 15%, polygonatum oil 2%, leek seed oil 20%, peony seed oil 30%, silkworm pupa oil 3%, Cistanche oil 20%, black sesame oil 3%, walnut oil 2%.

[0037] Preferably, the capsule core material comprises the following raw materials by mass percentage:

[0038] Rehmannia oil 8%, wolfberry oil 10%, polygonatum oil 2%, leek seed oil 15%, peony seed oil 35%, silkworm pupa oil 5%, Cistanche oil 15%, black sesame oil 5%, walnut oil 5%.

[0039] Preferably, the cooked rehmannia butter is made from nine-steamed and nine-processed cooked rehmannia, which is crushed to an average particle size of 0.3-0.6 mm, and then dried to a moisture content of <5%, and extracted with 5-10% ethanol as an entrainer and supercritical carbon dioxide as a solvent, with an extraction pressure of 25-30 MPa and an extraction temperature of 45-55°C.

[0040] Preferably, wolfberry oil is prepared by the following method:

[0041] The wolfberry fruit is dried, crushed, and put into an extraction kettle with an extractant at a solid-liquid ratio of 1:10-1:20; continuous extraction is carried out in the extraction reaction kettle, and the extraction is performed 15-20 times within 10-150 minutes; the separation pressure of the continuous extraction is 0.10-1.95MPa, and the separation temperature is 10-90°C; the extract is collected, and after the extract is allowed to stand at room temperature for 60-90 minutes, the extractant is removed to obtain wolfberry oil.

[0042] Preferably, silkworm chrysalis oil is prepared by the following method:

[0043] The silkworm pupae are cleaned, dried and crushed; the crushed silkworm pupae are mixed with petroleum ether at a ratio of 1: (2-5) g / ml, subjected to ultrasonic reflux extraction, vacuum filtration to obtain oil, and vacuum distillation to obtain silkworm pupa oil.

[0044] Preferably, the Cistanche deserticola oil is prepared by the following method:

[0045] Drying and crushing the Cistanche deserticola, then putting the Cistanche deserticola powder into an extraction kettle, extracting with supercritical carbon dioxide at 30-40°C and 20-30MPa for 2-4 hours, and collecting the extract;

[0046] Activated carbon decolorization and high temperature deodorization are used to obtain Cistanche deserticola oil.

[0047] Preferably, yellow osmanthus oil is prepared by the following method:

[0048] The steamed polygonatum is crushed, and then added into 80% ethanol aqueous solution, refluxed for extraction, and the extracts obtained by multiple reflux extractions are combined, filtered, and concentrated under reduced pressure to a water content of less than 5%, thereby obtaining polygonatum oil.

[0049] The remaining leek seed oil, peony seed oil, black sesame oil and walnut oil are all cold-pressed oils and can be purchased directly from the market.

[0050] On the other hand, an embodiment of the present invention provides a method for preparing a Chinese medicine composition for replenishing both qi and blood, characterized in that it comprises:

[0051] S1 mixes cyclodextrin with water and stirs evenly; adds polygonatum odoratum oil, leek seed oil and walnut oil, stirs for 1-2 hours, freeze-dries and obtains microcapsule powder; wherein, S1 mixes cyclodextrin with water and stirs evenly; adds polygonatum odoratum oil, leek seed oil and walnut oil, stirs for 1-2 hours, freeze-dries and obtains microcapsule powder; wherein, the ratio of cyclodextrin to the total mass of polygonatum odoratum oil, leek seed oil and walnut oil is 1:(10-15);

[0052] S2: uniformly mix the microcapsule powder with the remaining raw materials and put them into capsules to obtain a Chinese medicine composition.

[0053] The features and performance of the present invention are further described in detail below in conjunction with the embodiments.

[0054] Example 1

[0055] Prepare the cooked butter as follows:

[0056] Clean nine-steamed and nine-processed Rehmannia root was selected, crushed to an average particle size of 0.3-0.6 mm, and then dried to a water content of less than 5%. 10% ethanol aqueous solution was used as an entrainer and supercritical carbon dioxide was used as a solvent for extraction treatment. The extraction pressure was 30 MPa and the extraction temperature was 45°C.

[0057] Prepare wolfberry oil as follows:

[0058] The wolfberry fruit is dried, crushed, and put into an extraction kettle with an extractant at a solid-liquid ratio of 1:10; continuous extraction is carried out in the extraction reactor, and the extraction is performed 20 times within 15 minutes; the separation pressure of the continuous extraction is 1MPa and the separation temperature is 70°C; the extract is collected, and after the extract is allowed to stand at room temperature for 90 minutes, the extractant is removed to obtain wolfberry oil.

[0059] Prepare silkworm pupa oil as follows:

[0060] The silkworm pupae are cleaned, dried and crushed; the crushed silkworm pupae are mixed with petroleum ether at a ratio of 1:5 g / ml, subjected to ultrasonic reflux extraction, vacuum filtration to obtain oil, and vacuum distilled to obtain silkworm pupa oil.

[0061] Prepare Cistanche deserticola oil as follows:

[0062] The Cistanche deserticola is dried and crushed, and then the Cistanche deserticola powder is put into an extraction kettle, extracted with supercritical carbon dioxide at 40°C and 30MPa for 4 hours, and the extract is collected; activated carbon decolorization and high-temperature deodorization are performed to obtain Cistanche deserticola oil.

[0063] The yellow essential oil was prepared as follows:

[0064] The steamed polygonatum is crushed, added to 80% ethanol aqueous solution, refluxed and extracted at 50°C for 2h, the extracts from multiple reflux extractions are combined, filtered, and concentrated under reduced pressure to a water content of <5%, thereby obtaining polygonatum oil.

[0065] Prepare the raw materials according to the following ratio:

[0066] Rehmannia oil 5%, wolfberry oil 15%, polygonatum oil 2%, leek seed oil 20%, peony seed oil 30%, silkworm pupa oil 3%, Cistanche oil 20%, black sesame oil 3%, walnut oil 2%.

[0067] The Chinese medicine composition capsule of this embodiment is prepared as follows:

[0068] S1: Mix cyclodextrin and water and stir evenly; add polygonatum odoratum oil, leek seed oil and walnut oil, stir for 2 hours, freeze-dry and obtain microcapsule powder; wherein the total mass ratio of cyclodextrin to polygonatum odoratum oil, leek seed oil and walnut oil is 1:10;

[0069] S2: Evenly mix the microcapsule powder with the remaining raw materials and put them into capsules to obtain a Chinese medicine composition. The content of the core material in each capsule is about 0.5g, and the content of the capsule wall material is 0.2g.

[0070] Example 2

[0071] Prepare the raw materials according to the following ratio:

[0072] Rehmannia oil 8%, wolfberry oil 10%, polygonatum oil 2%, leek seed oil 15%, peony seed oil 35%, silkworm pupa oil 5%, Cistanche oil 15%, black sesame oil 5%, walnut oil 5%.

[0073] The Chinese medicine composition capsule of this embodiment is prepared as follows:

[0074] S1: Mix cyclodextrin with water and stir evenly; add polygonatum odoratum oil, leek seed oil and walnut oil, stir for 2 hours, freeze-dry and obtain microcapsule powder; wherein the total mass ratio of cyclodextrin to polygonatum odoratum oil, leek seed oil and walnut oil is 1:15;

[0075] S2: Evenly mix the microcapsule powder with the remaining raw materials and put them into capsules to obtain a Chinese medicine composition. The content of the core material in each capsule is about 0.5g, and the content of the capsule wall material is 0.2g.

[0076] Example 3

[0077] Prepare the raw materials according to the following ratio:

[0078] Rehmannia oil 5%, wolfberry oil 15%, polygonatum oil 1%, leek seed oil 20%, peony seed oil 35%, silkworm pupa oil 1%, Cistanche oil 20%, black sesame oil 1%, walnut oil 2%.

[0079] The Chinese medicine composition capsule of this embodiment is prepared as follows:

[0080] S1: Mix cyclodextrin and water and stir evenly; add polygonatum odoratum oil, leek seed oil and walnut oil, stir for 1 hour, freeze-dry and obtain microcapsule powder; wherein the total mass ratio of cyclodextrin to polygonatum odoratum oil, leek seed oil and walnut oil is 1:10;

[0081] S2: Evenly mix the microcapsule powder with the remaining raw materials and put them into capsules to obtain a Chinese medicine composition. The content of the core material in each capsule is about 0.5g, and the content of the capsule wall material is 0.2g.

[0082] Example 4

[0083] Prepare the raw materials according to the following ratio:

[0084] Rehmannia oil 7%, wolfberry oil 12%, polygonatum oil 1.5%, leek seed oil 18%, peony seed oil 33%, silkworm pupa oil 5%, Cistanche oil 18%, black sesame oil 3%, walnut oil 2.5%.

[0085] The Chinese medicine composition capsule of this embodiment is prepared as follows:

[0086] S1: Mix cyclodextrin with water and stir evenly; add polygonatum odoratum oil, leek seed oil and walnut oil, stir for 1.5 hours, freeze-dry and obtain microcapsule powder; wherein the total mass ratio of cyclodextrin to polygonatum odoratum oil, leek seed oil and walnut oil is 1:15;

[0087] S2: Evenly mix the microcapsule powder with the remaining raw materials and put them into capsules to obtain a Chinese medicine composition. The content of the core material in each capsule is about 0.5g, and the content of the capsule wall material is 0.2g.

[0088] Example 5

[0089] Prepare the raw materials according to the following ratio:

[0090] Rehmannia oil 8%, wolfberry oil 14%, polygonatum oil 1%, leek seed oil 15%, peony seed oil 35%, silkworm pupa oil 1%, Cistanche oil 20%, black sesame oil 5%, walnut oil 1%.

[0091] The Chinese medicine composition capsule of this embodiment is prepared as follows:

[0092] S1: Mix cyclodextrin and water and stir evenly; add polygonatum odoratum oil, leek seed oil and walnut oil, stir for 2 hours, freeze-dry and obtain microcapsule powder; wherein the total mass ratio of cyclodextrin to polygonatum odoratum oil, leek seed oil and walnut oil is 1:10;

[0093] S2: Evenly mix the microcapsule powder with the remaining raw materials and put them into capsules to obtain a Chinese medicine composition. The content of the core material in each capsule is about 0.5g, and the content of the capsule wall material is 0.2g.

[0094] Typical Cases

[0095] Case 1

[0096] Age: 28 years old. Main complaint: fatigue, dizziness, palpitations, pale complexion, and insufficient milk 3 months after delivery. Medical history: heavy bleeding after cesarean section, insufficient recuperation. Symptoms: pale tongue with thin white fur, weak pulse; blood routine showed low hemoglobin (98g / L); small amount of thin milk, soft but not swollen breasts. Diagnosis: postpartum deficiency of qi and blood, spleen and kidney deficiency.

[0097] The capsule of Example 1 was taken 2 times a day, 2 capsules each time, and after taking it for a course of treatment (7 days), blood routine showed that hemoglobin increased, and the main complaint of fatigue and dizziness decreased. After taking it for a course of treatment, the complexion became ruddy, and the symptoms of fatigue and dizziness disappeared. After taking it for a course of treatment, the above symptoms disappeared, the hemoglobin was normal, and the patient's mental state was good. After stopping use for one month, follow-up was conducted, and no symptoms such as dizziness and fatigue appeared.

[0098] Case 2

[0099] Age: 45 years old. Main complaint: easy fatigue, muscle aches, memory loss. Symptoms: pale, fat tongue with teeth marks, deep and slow pulse.

[0100] Taking the capsules of Example 1, 2 times a day, 2 capsules each time, once in the morning and evening, before meals, after taking one course of treatment, the main complaint of fatigue symptoms was alleviated, energetic, and then continued to take two courses of treatment, fatigue, muscle aches symptoms disappeared, the patient complained that the memory has improved, compared with before taking the capsules, not easy to forget things.

[0101] Case 3

[0102] Age: 72 years old. Main complaint: long-term fatigue, easy to catch cold, shortness of breath after activity. Symptoms: pale tongue with thin coating, weak pulse; blood routine showed mild anemia, electrocardiogram showed sinus bradycardia.

[0103] The capsules of Example 1 were taken 2 times a day, 2 capsules each time, once in the morning and evening, before meals. After taking one course of treatment, the legs and feet were strong and the fatigue was reduced. After continuing to take it for two months, the patient complained that the energy was better, there was no long-term fatigue, the tongue coating was normal, and the pulse was stronger than before taking it. The patient was told to take it continuously as daily health care. After a follow-up visit one year later, the patient's mental state was good, the main complaint was that the immunity was enhanced, and the number of colds was reduced compared with before taking it.

[0104] Case 4

[0105] Ms. Sun, 52 years old, is in menopause. The patient complained of hot flashes, night sweats, palpitations, insomnia, irritability, weakness in waist and knees, etc. Menstruation gradually became irregular, with less menstrual flow and pale color. She was easily fatigued, had a dull complexion, pale tongue with thin white fur, and a weak pulse. Diagnosis: TCM diagnosis was pre-menopausal and post-menopausal syndrome, Qi and blood deficiency syndrome.

[0106] After taking the capsule of Example 1 for one course of treatment, hot flashes and night sweats were significantly reduced, palpitations and insomnia symptoms were alleviated, and the mood was cheerful. After continuing to take it for 2 courses of treatment, the patient felt energetic and had less fatigue. According to Chinese medicine diagnosis, the deficiency of qi and blood was improved, and the patient was advised to continue taking it for 2 months.

[0107] In summary, the Chinese medicine composition of the embodiment of the present invention, each raw material medicine and food are of the same origin, and the composition has the effects of yin and yang supplementation, qi and blood supplementation, kidney and essence supplementation, nourishing yin and yang, cooked rehmannia oil contains polysaccharides, iridoid glycosides and other ingredients, has the effects of tonifying liver and kidney, improving soreness of waist and knees, dizziness and tinnitus, wolfberry oil is rich in linoleic acid, linolenic acid and wolfberry polysaccharides, can assist in relieving blurred vision and soreness of waist and knees caused by liver and kidney yin deficiency, and has the effect of nourishing liver and kidney. Polygonatum odoratum oil has the effects of replenishing qi and nourishing yin, strengthening spleen and moistening lung, replenishing essence and kidney, and enhancing immunity. Leek seed oil has multiple effects such as promoting blood circulation, regulating blood lipids, tonifying kidney and strengthening yang, promoting digestion, anti-oxidation, antibacterial and anti-inflammatory. Peony seed oil has the effects of lowering blood pressure and blood lipids, delaying aging, enhancing immunity, anti-oxidation, and protecting cardiovascular. Silkworm chrysalis oil has the effects of lowering lipids and cholesterol, lowering blood pressure, nourishing myocardium, preventing cardiovascular and cerebrovascular diseases, anti-oxidation, anti-aging, and enhancing immunity. Cistanche deserticola oil has the effects of nourishing the kidney and essence, moistening the intestines and relieving constipation, enhancing immunity, resisting fatigue, regulating endocrine and anti-aging. Black sesame oil has multiple effects such as anti-oxidation, moistening the intestines and relieving constipation, nourishing the liver and kidneys, black hair and beauty, improving skin elasticity, regulating blood lipids, enhancing immunity and preventing cardiovascular diseases. Walnut oil has the effects of lowering cholesterol, moistening the intestines and relieving constipation, anti-oxidation, anti-inflammatory, enhancing immunity and promoting calcium absorption. The raw materials are synergistic, and the medicine and food are of the same origin. The composition has the effects of tonifying both yin and yang, qi and blood, tonifying the kidney and essence, and nourishing yin and yang.

[0108] The embodiments described above are part of the embodiments of the present invention, rather than all of the embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for replenishing both qi and blood, characterized in that: It includes capsule wall material and capsule core material; the capsule core material includes the following raw materials by mass percentage: Rehmannia oil 5-8%, wolfberry oil 10-15%, polygonatum oil 1-2%, leek seed oil 15-20%, peony seed oil 30-35%, silkworm pupa oil 1-5%, Cistanche oil 15-20%, black sesame oil 1-5%, walnut oil 1-5%.

2. The Chinese medicine composition for replenishing both qi and blood according to claim 1, characterized in that: The capsule core material comprises the following raw materials by mass percentage: Rehmannia oil 5%, wolfberry oil 15%, polygonatum oil 2%, leek seed oil 20%, peony seed oil 30%, silkworm pupa oil 3%, Cistanche oil 20%, black sesame oil 3%, walnut oil 2%.

3. The Chinese medicine composition for replenishing both qi and blood according to claim 1, characterized in that: The capsule core material comprises the following raw materials by mass percentage: Rehmannia oil 8%, wolfberry oil 10%, polygonatum oil 2%, leek seed oil 15%, peony seed oil 35%, silkworm pupa oil 5%, Cistanche oil 15%, black sesame oil 5%, walnut oil 5%.

4. The Chinese medicine composition for replenishing both qi and blood according to claim 1, characterized in that: The cooked rehmannia butter is obtained by extracting Rehmannia root as a raw material and supercritical carbon dioxide as a solvent.

5. The Qi and blood-tonifying Chinese medicine composition according to claim 1, characterized in that: Wolfberry oil is prepared by the following method: The wolfberry is dried, crushed, and put into an extraction kettle with an extractant at a material-liquid ratio of 1:10 to 1:20; continuous extraction is performed in the extraction reaction kettle, and extraction is performed 15-20 times within 10 to 15 minutes; The separation pressure of the continuous extraction is 0.10-1.95 MPa, and the separation temperature is 10-90° C.; the extract is collected, and after the extract is allowed to stand at room temperature for 60-90 minutes, the extractant is removed to obtain wolfberry oil.

6. The Chinese medicine composition for replenishing both qi and blood according to claim 1, characterized in that: Silkworm pupa oil is prepared by the following method: The silkworm pupae are cleaned, dried and crushed; the crushed silkworm pupae are mixed with petroleum ether at a ratio of 1: (2-5) g / ml, subjected to ultrasonic reflux extraction, vacuum filtration to obtain oil, and vacuum distillation to obtain the silkworm pupa oil.

7. The Chinese medicine composition for replenishing both qi and blood according to claim 1, characterized in that: Cistanche deserticola oil is prepared by the following method: Drying and crushing the Cistanche deserticola, then putting the Cistanche deserticola powder into an extraction kettle, extracting with supercritical carbon dioxide at 30-40°C and 20-30MPa for 2-4 hours, and collecting the extract; The Cistanche deserticola oil is obtained by decolorization with activated carbon and deodorization at high temperature.

8. A method for preparing the Qi and blood-tonifying Chinese medicine composition according to any one of claims 1 to 7, characterized in that: It includes: S1, mixing cyclodextrin with water and stirring evenly; adding polygonatum odoratum oil, leek seed oil and walnut oil, stirring for 1-2h, and freeze-drying to obtain microcapsule powder; S2, mixing the microcapsule powder and other raw materials uniformly, and filling them into capsule wall materials to obtain the traditional Chinese medicine composition.

9. The method for preparing the Qi and blood-tonifying Chinese medicine composition according to claim 8, characterized in that: In step S1, the ratio of cyclodextrin to the total mass of polygonatum odoratum oil, leek seed oil and walnut oil is 1:(10-15).