Liquid film forming liquid with surface activity as well as preparation method and application of liquid film forming liquid

Abstract

The invention provides a liquid-forming film liquid with surface activity as well as a preparation method and application thereof, and relates to the fields of wound protection, wound repair, beauty and makeup and drug carrier materials. According to the liquid with the surface activity as well as the preparation method and the application of the liquid, the film-forming liquid with the surface activity comprises the following components in percentage by weight: 5wt%-30wt% of ascorbic acid boric acid polyester, 5wt%-30wt% of short-chain alcohol of which the C atom number is less than 5 and the balance of water. The surface tension value of the liquid with the surface activity is lower than that of water, and the liquid with the surface activity belongs to the field of surfactants, has the basic properties of adsorption and micelle formation, can form a liquid film on the surface of a wound surface, and covers the wound surface after forming a barrier, so that the surface activity of the wound surface is improved. The liquid with the surface activity has the effects of cleaning a wound surface and skin, wetting the wound surface and skin, preventing and treating infection, covering a protective barrier, controlling inflammation exudation and promoting healing. The invention further relates to a preparation method and application of the liquid with the surface activity.

Description

Technical Field

[0001] The invention relates to the fields of wound protection, wound repair, cosmetics and drug carrier materials, and specifically to a liquid film-forming liquid with surface activity and a preparation method and application thereof. Background Art

[0002] Traditional cotton gauze dressings often cause mechanical irritation or allergy, and adhere to wound secretions, causing secondary damage during dressing changes. Facial mask products often require liquid to be loaded on non-woven fabrics and other shaped mesh fabrics, which are inconvenient to carry and use.

[0003] For large-molecule polyurethane transparent dressings, while covering the wound, it makes the wound airtight, and at the same time, wound exudation causes it to separate from the wound surface; alginate silica sponge dressings, due to their porous structure, can absorb wound exudate through capillary action, but sponge dressings that absorb exudate, if not replaced in time, are prone to local diffusion, and sponge dressings that absorb exudate are not environmentally friendly; for hydrogel dressings such as chitosan and seaweed, they form gel on the wound surface, have a gel blocking effect, can absorb exudate and cover the wound surface, but their functions of preventing and treating infection and inflammation are weak, and they do not have the function of cleaning the wound surface.

[0004] A solution formed by small molecules with surface activity is sprayed to form droplets, which are attached to the wound surface, skin and other surfaces. The droplets merge, water evaporates, and the volume percentage of organic solvents increases, and finally a liquid film is formed. The small molecule solution with surface activity has the functions of wetting, dispersing, solubilizing, and cleaning. After the water evaporates, the liquid film is formed. The cost and safety are both controllable, and its synthesis conforms to the concept of "green chemistry". In view of this, a liquid film-forming liquid with surface activity and its preparation method and application are specially proposed. Summary of the invention

[0005] (I) Technical solution

[0006] To achieve the above objectives, the present invention is implemented through the following technical scheme: a liquid film-forming liquid with surface activity and its preparation method and application, the liquid film-forming solution with surface activity includes 5wt%-10wt% ascorbic acid boric acid polyester, 5wt%-10wt% short-chain alcohol with carbon number less than 5 and balance water.

[0007] Preferably, the surface active liquid film-forming solution comprises 5wt%-15wt% of ascorbic acid boric acid polyester, 5wt%-15wt% of a short-chain alcohol with a carbon number of less than 5 and the balance of water.

[0008] Preferably, the surface active liquid film-forming solution comprises 5wt%-30wt% of ascorbic acid boric acid polyester, 5wt%-30wt% of a short-chain alcohol having a carbon number of less than 5, and the balance water.

[0009] Preferably, the pH of the solution having a surface active liquid film is 5.0±1.0, and the surface tension value thereof is between 50.0±10.0 mN / m.

[0010] Preferably, the film-forming time of the solution having surface active liquid film is 3 min to 8 min.

[0011] Preferably, the solution having a surface active liquid film is a transparent liquid film.

[0012] Preferably, the method for preparing any of the above-mentioned solutions having a surface active liquid film comprises the steps of:

[0013] Borates (including boric acid and sodium tetraborate) are dissolved in water, and then ascorbic acid salts (including ascorbic acid and sodium ascorbate) are added to obtain an ascorbic acid boric acid polyester solution; short-chain alcohols with a carbon number of less than 5 (including one or more of propylene glycol, glycerol, and butanetriol) are added to the ascorbic acid boric acid polyester solution according to mass percentage, and the remainder of water is added to the total mass fraction of 100% to obtain the film-forming wound care solution.

[0014] Preferably, the step of obtaining the ascorbic acid boric acid polyester solution specifically includes: dissolving borates (including boric acid and sodium tetraborate) in water at a dissolution temperature of 30-90°C, and then adding ascorbic acid salts (including ascorbic acid and sodium ascorbate) to obtain an ascorbic acid boric acid polyester solution; adding a short-chain alcohol with a carbon number of less than 5 (including one or more of propylene glycol, glycerol, and butanetriol) to the ascorbic acid boric acid polyester solution by mass percentage, and adding the remainder of water to a total mass fraction of 100% to obtain the film-forming wound care solution.

[0015] Preferably, when obtaining the ascorbic acid boric acid polyester solution, the dissolution temperature can be independently selected from 30°C, 40°C, 50°C, 60°C, 70°C, 80°C, and 90°C.

[0016] (II) Beneficial effects

[0017] The present invention provides a surface-active liquid film-forming liquid and a preparation method and application thereof, which have the following beneficial effects:

[0018] 1. The present invention provides a liquid film-forming liquid with surface activity and a preparation method and application thereof. The liquid film-forming solution with surface activity forms a liquid film as the water in the solution evaporates and has no mechanical stimulation. The liquid dressing has two advantages: it can be applied to wounds of any shape; it can be used under any conditions, breaking through the limitations of traditional dressings and new tangible dressings.

[0019] 2. The present invention provides a liquid film-forming liquid with surface activity, a preparation method and application thereof, and a method for preparing a liquid film-forming solution with surface activity, which is simple, efficient and cost-controllable.

[0020] 3. The present invention provides a liquid film-forming liquid with surface activity, a preparation method and application thereof, and an application of the liquid film-forming solution with surface activity in wound care products, wound bandage-free products, and skin beauty. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a schematic diagram of the present invention;

[0022] Figure 2 It is a schematic diagram of the present invention;

[0023] Figure 3 It is a schematic diagram of the present invention;

[0024] Figure 4 It is a schematic diagram of the present invention. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] Example:

[0027] like Figure 1-4 As shown, an embodiment of the present invention provides a liquid film-forming liquid with surface activity, characterized in that: it includes 5wt%-10wt% ascorbic acid boric acid polyester, 5wt%-10wt% short-chain alcohol with a carbon number of less than 5 and the remainder water.

[0028] The pH of the solution with surface active liquid film is 5.0±1.0, the surface tension value thereof is between 50.0±10.0 mN / m, the film forming time of the solution with surface active liquid film is 3min to 8min, and the solution with surface active liquid film is a transparent liquid film.

[0029] As an embodiment, the method for preparing a liquid film-forming solution having surface activity comprises the steps of:

[0030] (1) At 80° C., add 15 g of sodium tetraborate to 30 mL of water, stir evenly, and after dissolving, add 15 g of ascorbic acid, stir and dissolve to obtain an ascorbic acid boric acid polyester solution, which is set aside for use;

[0031] (2) adding 15 g of propylene glycol and 15 g of glycerol at 80° C., stirring to dissolve, and then adding the remaining 70 mL of water to obtain a liquid film-forming solution having surface activity;

[0032] At least one of the above-mentioned film-forming wound care solution and the surface-active film-forming liquid solution prepared according to the above-mentioned method is used for wound surface and sprayed on the wound surface area to quickly form a film barrier;

[0033] In the present invention, boric acid (or sodium tetraborate hydrolyzed to form boric acid) is mixed with ascorbic acid (or ascorbic acid sodium salt) to undergo an esterification reaction. Figure 1 ;

[0034] The furan ring in ascorbic acid (salt) is a conjugated double bond structure, and the hydroxyl groups on C2 and C3 are esterified with boric acid to form a new five-membered ring of COB-0-C. Due to the electron-deficient property of the B atom, the electron cloud on the conjugated structure of the furan ring flows to B, forming a new five-membered heterocyclic ring with furan on both sides and B as a spiro atom, namely ascorbic acid boric acid polyester, as shown in the figure, with two hydrophilic groups of hydroxyl groups at each end, and a non-polar, i.e., hydrophobic, domain with average electron cloud in the middle. A compound containing a hydrophilic group and a hydrophobic group is an amphiphilic compound, and if its surface tension value is lower than the surface tension value of water, it is a surfactant. The surface-active film-forming solution of the present invention is tested by the hanging drop method and the hanging ring method for surface tension, and the values ​​are 42.218 and 48.8, respectively, which are lower than the surface tension value of water 72.8, and it is determined that the boric acid ascorbic acid polyester is a surfactant, and its solution is a surface-active solution;

[0035] Surfactants have the properties of adsorption and micelle formation. They are adsorbed on the wound surface to form an air-surfactant solution-wound interface, thus having the property of forming a liquid film. Surfactants have the property of micelle formation in the solution system. The ascorbic acid boric acid polyester molecular aggregates-micelles are rod-shaped structures with a diameter of <5um;

[0036] The solvent water evaporates, the micelles aggregate, and the solution forms a liquid film.

[0037] In the present invention, the film-forming solution with surface activity has the same dispersing effect as other surfactant solutions, adsorbs and encapsulates microorganisms, and the microorganisms are dispersed and suspended in the solution system to prevent the microorganisms from directly contacting the wound surface. At the same time, the dispersed microorganisms are inhibited from aggregating to avoid forming bacterial biofilms.

[0038] The hydrolytic proteases and endotoxins in the cell wall of Gram-negative bacteria can be adsorbed by the surfactant molecules mainly by hydrophobic action, so that the proteases and endotoxins lose their activity and avoid diffusion to cause inflammatory reactions; Gram-positive bacteria generally cause infection by releasing exotoxins to act on host cells, and the surface-active solution system of the present invention also mainly absorbs and encapsulates exotoxins by hydrophobic action to form an exotoxin (protein)-surfactant complex, which loses toxic activity. The dispersed and encapsulated microorganisms and the hydrolytic proteases or toxins released by them can be cleaned from the wound surface as the dressing is changed. Therefore, the surface-active film-forming solution of the present invention has the effect of preventing and treating infection, and its unique mechanism of action makes it free of bacterial resistance, regardless of bacterial species, and different from the pharmacological antibacterial mechanisms such as antibiotics acting on cell walls, cell membranes, and intracellular DNA, it prevents and treats infection through a mechanism based on the hydrophobic action of non-covalent chemistry.

[0039] In the present invention, the film-forming solution with surface activity reduces the surface tension of the wound surface and the incision, and reduces the scar formation. Human skin is usually under tension. When the skin is injured, the tension will cause the skin to crack, which will cause a normal scar. Increasing the tension of the skin may cause a hypertrophic scar; on the contrary, reducing the skin tension will reduce the skin scar. The dermis layer of the skin, the solution of the present invention directly reduces the surface tension of the wound surface or the wound, inhibits and reduces the scar, and makes the healing appearance smooth and beautiful in clinical use, promoting healing.

[0040] In the present invention, after the film-forming solution with surface activity is sprayed onto the wound surface, the solution covers the wound surface to form an air-solution interface of the present invention. The adsorption property of the surfactant ascorbic acid boric acid polyester, with its hydrophilic group facing the wound surface and the hydrophobic structure facing the air, plays a moisturizing role.

[0041] In the present invention, after the film-forming solution with surface activity is sprayed onto the wound surface, because the human body, especially the skin surface, is a natural evaporator with temperature, the water in the solution system evaporates, the concentration of ascorbic acid boric acid polyester in the solution increases, and micelle aggregates are aggregated to form micelle aggregates. As the water continues to evaporate, the micelle aggregates form a gel liquid film with short-chain alcohols, etc., so the liquid film formed by the solution of the present invention has the function of covering and protecting the wound surface.

[0042] In the present invention, the film-forming solution with surface activity has the effect of reducing the colloid osmotic pressure gradient in the wound area. According to Starling's law, exudation is the difference between the intravascular hydrostatic pressure and the extravascular hydrostatic pressure gradient, and the difference between the intravascular protein colloid osmotic pressure and the extravascular colloid osmotic pressure difference, that is, exudation = (intravascular hydrostatic pressure-extravascular hydrostatic pressure)-(intravascular protein colloid osmotic pressure-extravascular colloid osmotic pressure), the damaged wound surface, the capillary permeability increases, the plasma protein exudates to the outside of the blood vessel, causing the extravascular colloid osmotic pressure to increase, which is the direct physical variable leading to exudation. In the surface-active solution of the present invention, the surfactant ascorbic acid boric acid polyester and the protein form a complex through a hydrophobic physical effect, which directly reduces the extravascular colloid osmotic pressure, thereby achieving the effect of controlling exudation.

[0043] In the present invention, the film-forming solution with surface activity can absorb microorganisms, foreign matter, damaged cell tissue fragments, and inflammatory exudates wrapped around the wound surface, separate them from the wound matrix, and with the help of water flushing, it can achieve the function of cleaning and restore the surface of the skin, mucous membranes, etc.

[0044] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A liquid film-forming liquid having surface activity, characterized in that: The ± comprises 5wt%-10wt% of ascorbic acid boric acid polyester, 5wt%-10wt% of short-chain alcohol with carbon number less than 5 and the balance of water.

2. The surface-active liquid film-forming liquid according to claim 1, characterized in that: The ± comprises 5wt%-15wt% of ascorbic acid boric acid polyester, 5wt%-15wt% of short-chain alcohol with carbon number less than 5 and the balance of water.

3. The surface-active liquid film-forming liquid according to claim 1, characterized in that: The surface active wound liquid comprises 5wt%-30wt% of ascorbic acid boric acid polyester, 5wt%-30wt% of short-chain alcohol with carbon number less than 5 and the balance of water.

4. The surface-active liquid film-forming liquid according to claim 1, characterized in that: The pH of the liquid with surface activity is 5.0±1.

0. The film-forming time of the liquid with surface activity is 3min-8min, and the surface tension value of the liquid with surface activity is between 50±10mN / m.

5. The method for preparing a surface-active liquid film-forming liquid according to claim 1, characterized in that: The method comprises the steps of: heating and mixing borates (including boric acid and sodium tetraborate) and ascorbates (including ascorbic acid and sodium ascorbate) in water according to mass percentage to obtain an ascorbic acid boric acid polyester solution; adding short-chain alcohols with a carbon number of less than 5 (including one or more of propylene glycol, glycerol and tetratetrol) to the ascorbic acid boric acid polyester solution according to mass percentage, stirring and mixing to obtain the surface-active wound liquid.

6. The method for preparing a surface-active liquid film-forming liquid according to claim 5, characterized in that: The step of obtaining the ascorbic acid boric acid polyester solution specifically includes: dissolving a borate (including boric acid and sodium tetraborate) in water at a dissolution temperature of 30° C. to 90° C. by mass percentage, and then adding an ascorbate (including ascorbic acid and sodium ascorbate) to obtain the ascorbic acid boric acid polyester solution. The total concentration is 0.1 g / ml to 5.0 g / ml.

7. The method for preparing a surface-active liquid film-forming liquid according to claim 5, characterized in that: When obtaining the ascorbic acid boric acid polyester solution, the temperature is between 30-90°C.

8. Use of the surfactant liquid according to any one of claims 1 to 4 in mucosal dressings, wound dressings, medical and cosmetic dressings, cosmetics, drug carrier materials, etc.

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