Biological pharmaceutical microorganism culture device

Abstract

The biological pharmaceutical microorganism culture device comprises a culture box and a sealing cover plate, the sealing cover plate is rotationally connected with a second oval block, the second oval block is rotationally connected with the culture box, a connecting block is fixedly connected to the side, away from the culture box, of the second oval block, and the connecting block is in transmission connection with a first bevel gear; the first bevel gear is in meshed connection with a second bevel gear, the second bevel gear is in transmission connection with an in-box gear, the in-box gear is in meshed connection with a rack, the rack is fixed to one side of the vertical block, after microorganism culture is completed, an operator only needs to turn over a sealing cover plate, and the sealing cover plate is turned over leftwards to drive a second oval block to rotate with a connecting block as the axis; through transmission of a belt, a connecting block, a first bevel gear, a second bevel gear, a transmission belt and other components, a gear in the incubator rotates and is meshed with a rack, finally, the bottom plate slides to be flush with an opening of the incubator, and an operator can easily take out the bottom plate to comprehensively clean the interior of the incubator.

Description

Technical Field

[0001] The invention relates to the technical field of microorganism cultivation, and in particular to a biopharmaceutical microorganism cultivation device. Background Art

[0002] As an important part of today's medical field, biopharmaceuticals play a key role in disease treatment, prevention and diagnosis. The production of various biological products such as antibiotics, vaccines, enzymes, amino acids, etc. through microbial fermentation technology has the advantages of high efficiency, environmental protection and sustainability, and has become one of the core production methods of the biopharmaceutical industry. The growth and metabolic process of microorganisms directly determines the output and quality of biological products. Therefore, suitable microbial culture equipment is crucial to the success of biopharmaceuticals.

[0003] However, after the microbial cultivation task is completed, due to the numerous internal components and complex layout of the device, it is difficult for the operator to comprehensively and conveniently clean every corner and component. Moreover, if the sterilization process is not thoroughly performed before the cultivation device is put into use, the microorganisms remaining in the device will rapidly multiply in large numbers during the subsequent cultivation process. These miscellaneous bacteria will compete with the target cultured microorganisms for nutrients and living space, thereby seriously contaminating the culture and affecting the quality and efficiency of biopharmaceuticals. The present invention is to propose a biopharmaceutical microbial cultivation device to alleviate the technical problem of inconvenient cleaning by operators after the microbial cultivation is completed in the prior art. Summary of the invention

[0004] The purpose of the present invention is to solve the problem in the prior art that after the microbial cultivation task is completed, it is difficult for the operator to clean all corners and parts comprehensively and conveniently due to the numerous internal components and complex layout of the device. Moreover, if the sterilization process is not thoroughly performed before the cultivation device is put into use, the microorganisms remaining in the device will rapidly multiply in large numbers during the subsequent cultivation process. These miscellaneous bacteria will compete with the target cultured microorganisms for nutrients and living space, and then seriously contaminate the culture, affecting the quality and efficiency of biopharmaceuticals, and a biopharmaceutical microbial cultivation device is proposed.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A biopharmaceutical microorganism culture device comprises an incubator and a sealing cover plate, wherein the sealing cover plate is rotatably connected to a second elliptical block, the second elliptical block is rotatably connected to the incubator, a side of the second elliptical block away from the incubator is fixedly connected to a connecting block, the connecting block is transmission-connected to a first bevel gear, the first bevel gear is meshingly connected to a second bevel gear, the second bevel gear is transmission-connected to an internal gear of the box, the internal gear of the box is meshingly connected to a rack, the rack is fixed to one side of a vertical block, a bottom plate is rotatably connected below the vertical block, the bottom plate is slidably connected to the incubator, and a folding plate is rotatably connected to a side of the vertical block away from the bottom plate.

[0007] The above technical solution further includes:

[0008] The sealing cover plate is fixedly connected to a rotating rod on the side, the rotating rod is rotatably connected to one end of the second elliptical block, the connecting block is transmission-connected to a belt, the belt is transmission-connected to a connecting block, the connecting block is fixed to the side of the first bevel gear away from the incubator, one side of the second bevel gear is fixedly connected to a gear rod, the gear rod is transmission-connected to a transmission belt, and the side of the transmission belt away from the gear rod is transmission-connected to the gear inside the box. When the operator folds the sealing cover plate, the second elliptical block is driven to rotate by the rotating rod, and then the connecting block, belt, connecting block, first bevel gear, second bevel gear, gear rod and transmission belt are sequentially transmitted, and finally the gear inside the box is rotated. This transmission system provides a power transmission basis for the subsequent movement of the bottom plate and the linkage operation of the internal components of the incubator, which is convenient for cleaning the incubator after the culture is completed.

[0009] The gear inside the box is arranged inside the square cavity. The square cavity protects and positions the gear inside the box, which can prevent the gear inside the box from being disturbed or offset during rotation, thereby ensuring the stability and accuracy of the gear transmission, thereby ensuring the normal operation of the entire transmission system, and further ensuring the smooth progress of subsequent cleaning and other operations.

[0010] A plurality of groups of temperature sensors are arranged above the bottom plate, and a support column is arranged above the bottom plate, and the support column is used to support the folding plate. The temperature sensor can monitor the temperature above the bottom plate in real time, and provide accurate temperature data for the cultivation of microorganisms in the tank, so as to adjust the temperature through coolers and other equipment according to the actual situation, and ensure that the microorganisms grow in a suitable temperature environment. The support column supports the folding plate, ensures the stability of the folding plate during normal use, and also provides a structural basis for the subsequent folding operation of the folding plate along the vertical block, so as to facilitate the cleaning of the containers at the bottom of the folding plate and the surface of the bottom plate.

[0011] The tank is fixedly connected above the bottom plate, and a cooler for adjusting the temperature of the tank is arranged above the bottom plate. The tank is the core place for microbial cultivation, and fixing it above the bottom plate ensures the stability of the cultivation process. The cooler can adjust the temperature of the tank according to the temperature information fed back by the temperature sensor, so that the temperature inside the tank is kept within a range suitable for microbial growth, providing a stable temperature environment for microbial cultivation, and helping to improve the quality and efficiency of biopharmaceuticals.

[0012] A plurality of groups of heating lamps are arranged below the folding plate, and the heating lamps are used for irradiating the upper part of the bottom plate.

[0013] A plurality of support piers are arranged under the incubator, and a display panel is fixedly connected to the side of the incubator. The support piers provide stable support for the incubator, ensuring the stability of the incubator during operation and reducing the impact of external vibrations on the incubation process. The display panel can display various parameters in the incubator in real time, such as temperature and humidity, so that the operator can understand the status of the incubation environment at any time, make adjustments and interventions in a timely manner, and improve the convenience and accuracy of operation.

[0014] The sealing cover is rotatably connected to one side of the first elliptical block, and the first elliptical block is rotatably connected to a culture box at a side away from the sealing cover.

[0015] The side of the incubator is provided with a square groove for the gears in the box to rotate. The square groove provides a rotation space for the gears in the box, ensuring that the gears in the box will not be hindered by the side structure of the incubator during the rotation process. This ensures the smooth operation of the transmission system, enables the gears in the box to rotate normally according to the design requirements, and then realizes the movement of the bottom plate and the linkage operation of the internal components of the incubator, creating conditions for cleaning work after the cultivation is completed.

[0016] The bottom of the sealing cover is provided with a sealing soft layer for fitting on the surface of the incubator, and the sealing soft layer can enhance the sealing between the sealing cover and the incubator. During the incubation process, it can effectively prevent the outside air, dust and bacteria from entering the incubator, maintain the sterile environment in the incubator, and provide good conditions for microbial cultivation. At the same time, the sealing soft layer can also play a buffering role, reduce the impact force on the surface of the incubator when the sealing cover is closed, and protect the structural integrity of the incubator and the sealing cover.

[0017] The present invention has the following beneficial effects:

[0018] 1. In the present invention, after the microbial culture is completed, the operator only needs to fold the sealing cover plate to drive a series of components to work together. The sealing cover plate folds to the left to drive the second elliptical block to rotate with the connecting block as the axis, and then through the transmission of the belt, the connecting block, the first bevel gear, the second bevel gear, the transmission belt and other components, the gear in the box rotates and meshes with the rack, and finally the bottom plate slides to be flush with the opening of the incubator. At this time, the operator can easily take out the bottom plate and thoroughly clean the inside of the incubator. At the same time, the folding plate can also be folded along the vertical block, which is convenient for cleaning the bottom of the folding plate and various containers placed on the surface of the bottom plate. This design avoids the cleaning dead corners caused by the numerous internal components and complex layout of the device.

[0019] 2. In the present invention, since the device is easy to clean, the interior of the incubator and related components can be thoroughly cleaned after the microbial culture is completed, thereby significantly reducing the number of residual microorganisms. Before the culture device is put into use, more thorough cleaning helps to improve the sterilization effect and reduce the risk of incomplete sterilization. The possibility of microorganisms remaining in the device multiplying in large numbers during the subsequent culture process is reduced, and the competition between miscellaneous bacteria and target culture microorganisms for nutrients and living space is avoided, which effectively prevents the culture from being contaminated and reduces product failures and production losses caused by miscellaneous bacteria contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the structure of a biopharmaceutical microorganism culture device proposed by the present invention;

[0021] Figure 2 for Figure 1 The enlarged schematic diagram at A in the middle;

[0022] Figure 3 It is a schematic diagram of the external structure of the present invention;

[0023] Figure 4 for Figure 3 The enlarged schematic diagram of point B in the middle;

[0024] Figure 5 It is a schematic diagram of the internal structure of the incubator in the present invention;

[0025] Figure 6 for Figure 5 The enlarged schematic diagram at C in the middle;

[0026] Figure 7 It is a schematic diagram of the side structure of the lifting platform mechanism in the present invention.

[0027] In the figure: 1. incubator; 2. sealing cover; 3. supporting pier; 4. rotating rod; 5. connecting block; 6. belt; 7. first bevel gear; 8. connecting block; 9. second bevel gear; 10. gear rod; 11. transmission belt; 12. square groove; 13. gear in the box; 14. square cavity; 15. rack; 16. vertical block; 17. folding plate; 18. bottom plate; 19. temperature sensor; 20. heating lamp; 21. pillar; 22. tank; 23. cooler; 24. display panel; 25. first elliptical block; 26. second elliptical block. DETAILED DESCRIPTION

[0028] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0029] See also Figure 1-Figure 7 As shown, the present invention is a biopharmaceutical microorganism culture device, including a culture box 1 and a sealing cover plate 2, the sealing cover plate 2 is rotatably connected to the second elliptical block 26, the second elliptical block 26 is rotatably connected to the culture box 1, the second elliptical block 26 is fixedly connected to a connecting block 5 on a side away from the culture box 1, the connecting block 5 is transmission-connected to a first bevel gear 7, the first bevel gear 7 is meshingly connected to a second bevel gear 9, the second bevel gear 9 is transmission-connected to an internal gear 13, the internal gear 13 is meshingly connected to a rack 15, the rack 15 is fixed to one side of a vertical block 16, a bottom plate 18 is rotatably connected below the vertical block 16, the bottom plate 18 is slidably connected to the culture box 1, and a folding plate 17 is rotatably connected to a side of the vertical block 16 away from the bottom plate 18.

[0030] In one embodiment, for the above-mentioned sealing cover plate 2, a rotating rod 4 is fixedly connected to the side of the sealing cover plate 2, the rotating rod 4 is rotatably connected to one end of the second elliptical block 26, the connecting block 5 is transmission-connected to a belt 6, the belt 6 is transmission-connected to a connecting block 8, the connecting block 8 is fixed to the side of the first bevel gear 7 away from the incubator 1, a gear rod 10 is fixedly connected to one side of the second bevel gear 9, the gear rod 10 is transmission-connected to a transmission belt 11, and the side of the transmission belt 11 away from the gear rod 10 is transmission-connected to the gear 13 inside the box.

[0031] In this embodiment, when the operator folds the sealing cover plate 2, the second elliptical block 26 is driven to rotate by the rotating rod 4, and then the connecting block 5, the belt 6, the connecting block 8, the first bevel gear 7, the second bevel gear 9, the gear rod 10 and the transmission belt 11 are sequentially driven to finally rotate the gear 13 in the box. This transmission system provides a power transmission basis for the subsequent movement of the bottom plate 18 and the linkage operation of the internal components of the incubator 1, which is convenient for cleaning the incubator 1 after the incubation is completed.

[0032] In one embodiment, for the above-mentioned internal gear 13 , the internal gear 13 is disposed inside the square cavity 14 .

[0033] In this embodiment, the gear 13 in the box is arranged inside the square cavity 14, and the square cavity 14 plays a role in protecting and positioning the gear 13 in the box. The gear 13 in the box can be prevented from being disturbed or offset by the outside world during the rotation process, thereby ensuring the stability and accuracy of the gear transmission, thereby ensuring the normal operation of the entire transmission system, and further ensuring the smooth progress of subsequent cleaning and other operations.

[0034] In one embodiment, for the temperature sensors 19 , a plurality of groups of temperature sensors 19 are disposed above the bottom plate 18 , and pillars 21 are disposed above the bottom plate 18 , and the pillars 21 are used to support the folding plate 17 .

[0035] In this embodiment, the temperature sensor 19 can monitor the temperature above the bottom plate 18 in real time, provide accurate temperature data for the microorganism culture in the tank 22, and adjust the temperature through the cooler 23 and other equipment according to the actual situation to ensure that the microorganisms grow in a suitable temperature environment. The support 21 supports the folding plate 17, ensuring the stability of the folding plate 17 during normal use, and also provides a structural basis for the subsequent folding operation of the folding plate 17 along the vertical block 16, so as to facilitate the cleaning of the container at the bottom of the folding plate 17 and the surface of the bottom plate 18.

[0036] In one embodiment, for the above-mentioned bottom plate 18 , a tank body 22 is fixedly connected above the bottom plate 18 , and a cooler 23 for adjusting the temperature of the tank body 22 is arranged above the bottom plate 18 .

[0037] In this embodiment, the tank 22 is the core place for microorganism cultivation, and fixing it above the bottom plate 18 ensures the stability of the cultivation process. The cooler 23 can adjust the temperature of the tank 22 according to the temperature information fed back by the temperature sensor 19, so that the temperature in the tank 22 is kept within a range suitable for the growth of microorganisms, providing a stable temperature environment for microorganism cultivation, which helps to improve the quality and efficiency of biopharmaceuticals.

[0038] In one embodiment, for the folding plate 17 , a plurality of groups of heating lamps 20 are disposed below the folding plate 17 , and the heating lamps 20 are used to irradiate the top of the bottom plate 18 .

[0039] In one embodiment, for the above-mentioned display panel 24 , a plurality of groups of supporting piers 3 for support are arranged under the incubator 1 , and the display panel 24 is fixedly connected to the side of the incubator 1 .

[0040] In this embodiment, the support pier 3 plays a role in stabilizing the incubator 1, ensuring the stability of the incubator 1 during operation and reducing the impact of external vibrations on the incubation process. The display panel 24 can display various parameters in the incubator 1 in real time, such as temperature, humidity, etc., so that the operator can understand the status of the incubation environment at any time, make adjustments and interventions in time, and improve the convenience and accuracy of operation.

[0041] In one embodiment, for the sealing cover plate 2 , the sealing cover plate 2 is rotatably connected to one side of the first elliptical block 25 , and the side of the first elliptical block 25 away from the sealing cover plate 2 is rotatably connected to the incubator 1 .

[0042] In one embodiment, for the square groove 12 , a square groove 12 for the gear 13 inside the box to rotate is provided on the side of the incubator 1 .

[0043] In this embodiment, the square groove 12 provides a rotation space for the gear 13 in the box, ensuring that the gear 13 in the box will not be hindered by the side structure of the incubator 1 during the rotation process. This ensures the smooth operation of the transmission system, so that the gear 13 in the box can rotate normally according to the design requirements, thereby realizing the movement of the bottom plate 18 and the linkage operation of the internal components of the incubator 1, creating conditions for cleaning work after the cultivation is completed.

[0044] In one embodiment, for the sealing cover plate 2 , a sealing soft layer is disposed at the bottom of the sealing cover plate 2 for being attached to the surface of the incubator 1 .

[0045] In this embodiment, the sealing soft layer can enhance the sealing between the sealing cover plate 2 and the incubator 1. During the culture process, it can effectively prevent external air, dust and bacteria from entering the incubator 1, maintain the sterile environment in the incubator 1, and provide good conditions for microbial culture. At the same time, the sealing soft layer can also play a buffering role, reducing the impact force on the surface of the incubator 1 when the sealing cover plate 2 is closed, and protecting the structural integrity of the incubator 1 and the sealing cover plate 2.

[0046] The working principle of the biopharmaceutical microorganism cultivation device of the present invention is that after the microorganisms required for biopharmaceuticals are cultivated in the tank body 22, the sealing cover plate 2 is folded, and then the sealing cover plate 2 is rotatably connected to the second elliptical block 26 to Figure 4For example, the sealing cover plate 2 is folded to the left to drive the second elliptical block 26 to rotate to the left with the connecting block 5 as the axis. Then, when the sealing cover plate 2 is rotated until the surface is attached to the surface of the incubator 1, the second elliptical block 26 is folded to the maximum with the connecting block 5 as the axis. Then, during the rotation process, the second elliptical block 26 drives the belt 6 to transmit the transmission through the connecting block 5, and further drives the connecting block 8 to rotate. The rotation of the connecting block 8 drives the first bevel gear 7 to mesh with the second bevel gear 9. The rotation of the second bevel gear 9 drives the gear 13 in the box to rotate through the transmission belt 11. The gear 13 in the box The rotation will mesh with the rack 15 so that the bottom plate 18 slides with the inner wall of the incubator 1. As the folding degree of the second elliptical block 26 gradually becomes the maximum, the gear 13 in the box will mesh with the rack 15 so that the bottom plate 18 is flush with the opening of the incubator 1. At this time, the bottom plate 18 can be taken out and the inside of the incubator 1 can be cleaned. The folding plate 17 can be folded along the vertical block 16 to clean the bottom of the folding plate 17 and various containers placed on the surface of the bottom plate 18, thereby ensuring that the environment for culturing microorganisms can be used normally as biopharmaceutical materials.

[0047] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A biopharmaceutical microorganism culture device, characterized in that: The invention comprises an incubator (1) and a sealing cover plate (2), wherein the sealing cover plate (2) is rotatably connected to a second elliptical block (26), the second elliptical block (26) is rotatably connected to the incubator (1), a side of the second elliptical block (26) away from the incubator (1) is fixedly connected to a connecting block (5), the connecting block (5) is transmission-connected to a first bevel gear (7), the first bevel gear (7) is meshingly connected to a second bevel gear (9), the second bevel gear (9) is transmission-connected to an internal gear (13), the internal gear (13) is meshingly connected to a rack (15), the rack (15) is fixed to one side of a vertical block (16), a bottom plate (18) is rotatably connected below the vertical block (16), the bottom plate (18) is slidably connected to the incubator (1), and a side of the vertical block (16) away from the bottom plate (18) is rotatably connected to a folding plate (17).

2. A biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: A rotating rod (4) is fixedly connected to the side of the sealing cover plate (2), and the rotating rod (4) is rotatably connected to one end of the second elliptical block (26). The connecting block (5) is transmission-connected to a belt (6), and the belt (6) is transmission-connected to a connecting block (8). The connecting block (8) is fixed to a side of the first bevel gear (7) away from the incubator (1). A gear rod (10) is fixedly connected to one side of the second bevel gear (9), and the gear rod (10) is transmission-connected to a transmission belt (11), and a side of the transmission belt (11) away from the gear rod (10) is transmission-connected to a gear (13) inside the box.

3. A biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: The gear (13) inside the box is arranged inside the square cavity (14).

4. A biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: A plurality of groups of temperature sensors (19) are arranged above the bottom plate (18), and a support column (21) is arranged above the bottom plate (18), wherein the support column (21) is used to support the folding plate (17).

5. A biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: A tank body (22) is fixedly connected above the bottom plate (18), and a cooler (23) for adjusting the temperature of the tank body (22) is arranged above the bottom plate (18).

6. A biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: A plurality of groups of heating lamps (20) are arranged below the folding plate (17), and the heating lamps (20) are used to irradiate the upper part of the bottom plate (18).

7. A biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: A plurality of groups of supporting piers (3) are arranged below the incubator (1) and a display panel (24) is fixedly connected to the side of the incubator (1).

8. A biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: The sealing cover plate (2) is rotatably connected to one side of the first elliptical block (25), and the side of the first elliptical block (25) away from the sealing cover plate (2) is rotatably connected to the incubator (1).

9. A biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: The side of the incubator (1) is provided with a square groove (12) for the gear (13) inside the box to rotate.

10. The biopharmaceutical microorganism cultivation device according to claim 1, characterized in that: The bottom of the sealing cover plate (2) is provided with a circle of sealing soft layer for being attached to the surface of the incubator (1).

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