Extract yield detection method and production method of traditional Chinese medicine concentrated pill

Abstract

The invention relates to the technical field of traditional Chinese medicine detection, in particular to a method for detecting the extract yield in the production process of traditional Chinese medicine concentrated pills and a production method of the traditional Chinese medicine concentrated pills. The method for detecting the yield of the traditional Chinese medicine extract comprises the following steps: determining the standard relative density of the extract according to the variety of traditional Chinese medicine concentrated pills; obtaining the weight of the traditional Chinese medicinal materials for preparing the to-be-detected extract; obtaining the weight and the relative density of the to-be-detected extract; and obtaining the yield of the to-be-detected extract according to the standard relative density of the extract, the weight of the traditional Chinese medicinal materials and the weight and relative density of the to-be-detected extract. According to the method, the problem that an existing traditional Chinese medicine extract yield detection method is poor in aging effect is solved, the traditional Chinese medicine extract yield can be rapidly detected in the uninterrupted production process of traditional Chinese medicine concentrated pills, production examination is facilitated, and the quality of traditional Chinese medicine materials can be effectively evaluated.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of concentrated Chinese medicine pills, in particular to a method for detecting the yield of an extract in the production process of concentrated Chinese medicine pills, and a method for producing concentrated Chinese medicine pills. Background Art

[0002] Extract recovery is an important process in the production of concentrated Chinese medicine pills. It refers to the Chinese medicine extract obtained after a series of extraction processes such as soaking, decoction, and concentration of medicinal materials. Its purpose is to extract the active ingredients from the medicinal materials and provide raw materials for the subsequent processing of Chinese medicine preparations. In the extraction process of Chinese medicine, the recovery rate of Chinese medicine extract is a key process parameter, which reflects the effective conversion efficiency from the original medicinal materials to the final extract product. The recovery rate of Chinese medicine extract is of great significance for evaluating extraction efficiency, controlling costs, ensuring quality, and optimizing processes. In the production process of concentrated Chinese medicine pills, great importance is attached to the calculation and monitoring of the recovery rate of extract.

[0003] However, in the production process of Chinese medicine extraction, each batch of products is put into the same weight of medicinal pieces, and there are differences in the weight of the extract obtained after the extraction process such as soaking, decoction, and concentration. One of the main reasons for this difference is the different relative density of the extract. In order to avoid the influence of different relative densities on the yield calculation results, when testing the yield of Chinese medicine extract, it is currently necessary to dry the extract and obtain the weight of the dry paste powder; then use the ratio of the weight of the dry paste powder to the original medicinal material input to evaluate the yield of Chinese medicine extraction. In addition, in the continuous production process of Chinese medicine concentrated pills, the extract yield needs to be quickly evaluated, and the extract cannot be dried. Therefore, the above-mentioned Chinese medicine extract yield detection method has poor time-effectiveness and is not suitable for the actual needs of Chinese medicine concentrated pill production. Summary of the invention

[0004] In view of the above problems, the present invention is proposed to provide a method for detecting the yield of Chinese medicine concentrated pills and a method for producing Chinese medicine concentrated pills that overcome the above problems or at least partially solve the above problems, so as to solve the problem of poor timeliness and effectiveness of existing methods for detecting the yield of Chinese medicine extracts, so as to facilitate the rapid detection of the yield of Chinese medicine extracts during the uninterrupted production process of Chinese medicine concentrated pills, facilitate production assessment, and effectively evaluate the quality of Chinese medicinal materials.

[0005] Specifically, the present invention provides a method for detecting the yield of a concentrated Chinese medicine pill extract, comprising the following steps:

[0006] Determine the standard relative density of the extract according to the type of concentrated Chinese medicine pills;

[0007] Obtaining the weight of the Chinese medicinal materials used to prepare the extract to be tested;

[0008] Obtain the weight and relative density of the extract to be tested;

[0009] The yield of the extract to be tested is obtained according to the standard relative density of the extract, the weight of the Chinese medicinal material, and the weight and relative density of the extract to be tested.

[0010] Optionally, the step of obtaining the yield of the extract to be tested according to the standard relative density of the extract, the weight of the Chinese medicinal material, and the weight and relative density of the extract to be tested comprises:

[0011] Obtaining the converted weight of the extract to be tested according to the standard relative density of the extract, the weight and relative density of the extract to be tested;

[0012] The yield of the extract to be tested is obtained according to the converted weight and the weight of the Chinese medicinal material.

[0013] Optionally, the calculation formula for the converted weight of the extract to be tested is:

[0014]

[0015] The calculation formula of the yield of the extract to be tested is:

[0016]

[0017] Among them, M 折 is the converted weight of the extract to be tested;

[0018] M 药 is the weight of the Chinese medicinal material;

[0019] D 膏 is the relative density of the extract to be tested;

[0020] D 标 is the standard relative density of the extract;

[0021] M 膏 is the weight of the extract to be tested.

[0022] Optionally, the specific method for obtaining the relative density of the extract to be tested includes the following steps:

[0023] Weigh the empty specific gravity cup and get m 1 ;

[0024] Weigh the glass cover plate to get m 2 ;

[0025] Weigh the empty specific gravity cup filled with water and covered with a glass cover to obtain m 3 ;

[0026] Weigh the weight of the empty specific gravity cup after the extract to be tested is filled, and get m 4; Among them, the extract to be tested accounts for 1 / 4 to 1 / 3 of the weight cup;

[0027] Fill the density cup with water, cover it with a glass lid, and weigh the total weight of the density cup to get m. 5 ;

[0028] Calculate the relative density of the extract to be tested according to the following formula:

[0029]

[0030] Optionally, the step of determining the standard relative density of the extract according to the type of the concentrated Chinese medicine pills comprises:

[0031] According to the type of concentrated Chinese medicine pills, obtain the historical data of the relative density of the corresponding extract within a preset time period;

[0032] The standard relative density of the extract is determined based on the historical data.

[0033] On the other hand, the present invention also provides a method for producing concentrated Chinese medicine pills, comprising the following steps:

[0034] Prepare Chinese medicinal materials into Chinese medicinal extracts;

[0035] The Chinese medicine extract is used as the extract to be tested, and any one of the above-mentioned detection methods is used to obtain the yield of the Chinese medicine extract.

[0036] Optionally, the production method further comprises:

[0037] According to the yield of the Chinese medicine extract, the amount of the wetting agent used in the pill making step and the weight of the wet pills obtained are determined.

[0038] Beneficial effects of the present invention:

[0039] The present invention sets the standard relative density of the extract, and determines the yield of the extract to be tested according to the standard relative density of the extract, the weight of the Chinese medicinal material, the weight and relative density of the extract to be tested. The yield is the yield at the same relative density level. The present invention solves the problem that the relative density of extracts of different batches of products is different and affects the true result of the yield. Compared with the prior art, when the extract yield is detected by the present invention, there is no need to dry the extract, which significantly improves the detection efficiency. Therefore, the detection method of the present invention has good timeliness, is convenient for quickly calculating the yield of Chinese medicinal extracts in an uninterrupted production process, is convenient for production assessment, and can also be used to evaluate the quality of the Chinese medicinal materials used. Specifically, according to the real-time inspection data of the extract yield, the quality of the Chinese medicinal material raw materials currently used and whether the process parameters in the extract preparation process are qualified can be evaluated, so as to adjust the raw materials or process parameters in time according to the evaluation results. In addition, before a new batch of Chinese medicinal raw materials is put into use, it can be first prepared into an extract through experiments, and then the extract yield can be detected using the method of the present invention. The quality of the batch of Chinese medicinal raw materials can be evaluated based on the extract yield, so as to determine whether the batch of raw materials can be put into actual production based on the evaluation results.

[0040] Furthermore, according to the test results of the extract yield, the production process of the subsequent pill making step can be guided in real time.

[0041] Based on the following detailed description of specific embodiments of the present invention in conjunction with the accompanying drawings, those skilled in the art will become more aware of the above and other objects, advantages and features of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0042] Hereinafter, some specific embodiments of the present invention will be described in detail in an exemplary and non-limiting manner with reference to the accompanying drawings. The same reference numerals in the accompanying drawings indicate the same or similar components or parts. It should be understood by those skilled in the art that these drawings are not necessarily drawn to scale. In the accompanying drawings:

[0043] Figure 1 It is a schematic flow chart of a method for detecting the yield of a concentrated Chinese medicine pill extract according to an embodiment of the present invention;

[0044] Figure 2 The present invention is a schematic flow chart of a method for detecting the yield of a concentrated Chinese medicine pill extract according to an embodiment of the present invention. DETAILED DESCRIPTION

[0045] Refer to the following Figure 1 to Figure 2To describe the detection method of the yield of the Chinese medicine concentrated pill extract and the production method of the Chinese medicine concentrated pill in the embodiment of the present invention. In order to make the purpose, technical scheme and advantages of the embodiment of the present invention clearer, the technical scheme in the embodiment of the present invention will be described clearly and completely below. If the specific conditions are not indicated in the embodiment, they are carried out according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used without indicating the manufacturer are all conventional products that can be purchased commercially. In addition, the meaning of "and / or" appearing in the full text includes three parallel schemes. Taking "A and / or B" as an example, it includes scheme A, or scheme B, or schemes that A and B meet at the same time. In addition, the technical schemes between the various embodiments can be combined with each other, but they must be based on the ability of ordinary technicians in the field to achieve. When the combination of technical solutions is contradictory or cannot be achieved, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in the field without making creative work belong to the scope of protection of the present invention.

[0046] like Figure 1 As shown, an embodiment of the present invention provides a method for detecting the yield of a Chinese medicine extract, and the detection method may include the following steps:

[0047] S100, determine the standard relative density of the extract according to the type of concentrated Chinese medicine pills;

[0048] S200, obtaining the weight of the Chinese medicinal materials used to prepare the extract to be tested;

[0049] S300, obtaining the weight and relative density of the extract to be tested;

[0050] S400, obtaining the yield of the extract to be tested according to the standard relative density of the extract, the weight of the Chinese medicinal material, and the weight and relative density of the extract to be tested.

[0051] This embodiment sets the standard relative density of the extract, and determines the yield of the extract to be tested according to the standard relative density of the extract, the weight of the Chinese medicinal material, the weight and relative density of the extract to be tested. The yield is the yield at the same relative density level. This embodiment solves the problem that the different relative densities of extracts from different batches of products affect the actual result of the yield.

[0052] Compared with the prior art, when the extract yield is detected by this embodiment, there is no need to dry the extract, which significantly improves the detection efficiency. Therefore, the detection method of this embodiment has good timeliness, is convenient for quickly calculating the Chinese medicine extract yield in an uninterrupted production process, is convenient for production assessment, and can also be used to evaluate the quality of the Chinese medicine materials used. Specifically, according to the real-time inspection data of the extract yield, the quality of the Chinese medicine raw materials currently used and whether the process parameters in the extract preparation process are qualified can be evaluated, so as to adjust the raw materials or process parameters in time according to the evaluation results.

[0053] In addition, before a new batch of Chinese medicinal raw materials is put into use, it can be first prepared into an extract through experiments, and then the extract yield can be detected using the method of this embodiment, and the quality of the batch of Chinese medicinal raw materials can be evaluated based on the extract yield, so as to determine whether the batch of raw materials can be put into actual production based on the evaluation results.

[0054] Furthermore, the detection method of this embodiment can be used to guide the production process of the pill making step based on the detection results.

[0055] like Figure 2 As shown, in some embodiments of the present invention, the step of obtaining the yield of the extract to be tested according to the standard relative density of the extract, the weight of the Chinese medicinal material, the weight and relative density of the extract to be tested may include the following specific steps:

[0056] S410, obtaining the converted weight of the extract to be tested according to the standard relative density of the extract, the weight and relative density of the extract to be tested;

[0057] S420, obtaining the yield of the extract to be tested according to the converted weight and the weight of the Chinese medicinal material.

[0058] In this embodiment, the converted weight of the extract to be tested is first calculated based on the standard relative density of the extract, the weight of the extract to be tested and the relative density. That is, the weight of the extract is calculated at the same relative density level. Then, based on the converted weight of the extract and the weight of the Chinese medicinal materials, the yield of the extract to be tested at the same relative density level is obtained. The converted weight of the extract and the yield can be used to guide the subsequent production process of the Chinese medicine concentrated pills. The method for converting the weight of the extract in this embodiment has the advantages of scientific and reasonable design and simple and easy operation.

[0059] In some embodiments of the present invention, the calculation formula for the yield of the extract to be tested is:

[0060]

[0061] Among them, M 折 M is the converted weight of the extract to be tested; 药It is the weight of Chinese medicinal materials.

[0062] This embodiment provides a specific algorithm for the yield of the extract to be tested, and the algorithm can be used to quickly and accurately calculate the yield of the extract to be tested.

[0063] In some embodiments of the present invention, the calculation formula for the converted weight of the extract to be tested is:

[0064]

[0065] Among them, M 折 M is the converted weight of the extract to be tested; 膏 is the weight of the extract to be tested; D 膏 is the relative density of the extract to be tested; D 标 is the standard relative density of the extract.

[0066] This embodiment provides a specific algorithm for calculating the converted weight of the extract to be tested. The algorithm can be used to quickly and accurately calculate the converted weight of the extract to be tested.

[0067] In some embodiments of the present invention, the specific method for obtaining the relative density of the extract to be tested comprises the following steps:

[0068] S301, weigh the empty specific gravity cup and get m 1 ;

[0069] S302, weigh the glass cover plate to obtain m 2 ;

[0070] S303, weigh the weight of the specific gravity cup filled with water and covered with a glass cover, and obtain m 3 Specifically, fill the empty density cup with water, and spread a square glass plate from the side to the mouth of the density cup so that there are no bubbles where the glass plate contacts the water, and then weigh the total weight of the current density cup;

[0071] S304, weigh the weight of the extract to be tested in the specific gravity cup, and obtain m 4 ; Wherein, the extract to be tested accounts for 1 / 4 to 1 / 3 of the weight cup; Specifically, pour the extract to be tested into the empty specific gravity cup so that the volume of the extract to be tested accounts for 1 / 4 to 1 / 3 of the total volume in the specific gravity cup, and then weigh the current total weight of the specific gravity cup;

[0072] S305, fill the density cup containing the extract to be tested with water, cover it with a glass cover, and weigh the current total weight of the density cup to obtain m 5 Specifically, fill the density cup containing the extract to be tested obtained in S304 with water, and spread a square glass plate from the side to the mouth of the density cup so that there are no bubbles where the glass plate contacts the water, and then weigh the total weight of the current density cup;

[0073] S306, calculate the relative density of the extract to be tested according to the following formula:

[0074]

[0075] This embodiment provides a specific method for detecting the relative density of the extract to be tested. Under the same volume, by testing the ratio of the weight of the extract to the weight of water, the ratio of the density of the extract to the density of water, that is, the relative density of the extract, can be obtained. By using the method of this embodiment, the relative density of the extract can be measured quickly and accurately. And the method of this embodiment has the advantage of being simple and easy to operate.

[0076] In some embodiments of the present invention, the step of determining the standard relative density of the extract according to the type of the concentrated Chinese medicine pills may specifically include the following steps:

[0077] S110, obtaining historical data of relative density of extract corresponding to a preset time period according to the type of concentrated Chinese medicine pills;

[0078] S120, determining the standard relative density of the extract according to the historical data.

[0079] Specifically, the preset time period can be one year, six months, three months, or one month before the current time. The historical data of the relative density of the extract corresponding to the Chinese medicine concentrated pills of this variety within the preset time period is obtained, and then the average value of the above historical data is used as the standard relative density of the extract corresponding to the Chinese medicine concentrated pills. The standard relative density of the extract is set scientifically and reasonably. The above method can quickly obtain the standard relative density of the extract, thereby improving the detection efficiency of the extract to be tested.

[0080] In some embodiments of the present invention, a method for detecting the yield of a traditional Chinese medicine extract may include the following steps:

[0081] S1. Determine the standard relative density of the extract according to the type of concentrated Chinese medicine pills.

[0082] S2, according to the prescription of Chinese medicine concentrated pills, Chinese medicine (the weight of medicine is recorded as M 药 ) After a series of extraction processes such as soaking, boiling, and concentration, the obtained Chinese medicine extract is mixed evenly and weighed. The weight is recorded as M 膏 ; Take the Chinese medicine extract as the extract to be tested, cool the Chinese medicine extract to 20℃, and use a specific gravity bottle to measure the relative density of the Chinese medicine extract. The measured relative density is recorded as D 膏 .

[0083] S3, calculate the density of the extract to be tested according to the following formula:

[0084]

[0085] S4, calculate the yield of the extract to be tested according to the following formula:

[0086]

[0087] The combined method for converting the yield of Chinese medicine extract proposed in this embodiment is not only time-effective, but also can quickly adapt to the production rhythm, ensuring that the yield of Chinese medicine extract can be calculated immediately and accurately in an uninterrupted production process, and greatly facilitates the assessment and management of the production process, and improves production efficiency and quality control. In addition, the method also provides a scientific and quantitative basis for evaluating the quality of purchased Chinese medicinal materials, which helps enterprises control the quality of medicinal materials from the source, ensure the stability and efficacy of the final Chinese medicine products, and further enhance the market competitiveness of the products.

[0088] Another aspect of the embodiments of the present invention further provides a method for producing concentrated Chinese medicine pills, which may include the following steps:

[0089] S10, preparing Chinese medicinal materials into Chinese medicinal extracts;

[0090] S20, using the Chinese herbal medicine extract as the extract to be tested, and using any one of the detection methods in the above embodiments to obtain the yield of the Chinese herbal medicine extract.

[0091] In the production method of concentrated Chinese medicine pills, the inspection method of the above embodiment is used to detect the yield of Chinese medicine extract, which is convenient for quickly calculating the yield of Chinese medicine extract in an uninterrupted production process, facilitating production assessment and evaluating the quality of purchased Chinese medicine materials.

[0092] In some embodiments of the present invention, the method for producing concentrated Chinese medicine pills may further include the following steps: S30, determining the amount of the wetting agent used in the pill making step and the weight of the wet pills obtained according to the yield of the Chinese medicine extract.

[0093] Specifically, the pill making step is as follows: first, the Chinese medicine extract as the key adhesive component is fully mixed with the fine powder of the finely processed auxiliary materials to ensure that the two are evenly blended. Then, an appropriate amount of wetting agent (such as pure water or ethanol of different concentrations prepared according to needs) is introduced, and the amount of wetting agent added is precisely controlled to achieve the ideal material wettability and plasticity, which is convenient for subsequent molding operations.

[0094] In this embodiment, in the production process of the concentrated Chinese medicine pills, by accurately measuring and calculating the yield of the Chinese medicine extract, the amount of wetting agent used in the pill making process and the preset weight of the wet pills can be flexibly adjusted in real time. This dynamic control mechanism is crucial for optimizing the molding effect of the pills and improving the uniformity and stability of the pills, thereby significantly improving the overall quality of the concentrated Chinese medicine pills and ensuring that the products meet the established quality standards and efficacy requirements.

[0095] Multiple exemplary embodiments of the present invention, however, without departing from the spirit and scope of the present invention, many other variations or modifications that conform to the principles of the present invention can still be directly determined or derived based on the content disclosed in the present invention. Therefore, the scope of the present invention should be understood and identified as covering all these other variations or modifications.

Claims

1. A method for detecting the yield of a Chinese medicine extract, characterized in that: The following steps are involved: Determine the standard relative density of the extract according to the type of concentrated Chinese medicine pills; Obtaining the weight of the Chinese medicinal materials used to prepare the extract to be tested; Obtain the weight and relative density of the extract to be tested; The yield of the extract to be tested is obtained according to the standard relative density of the extract, the weight of the Chinese medicinal material, and the weight and relative density of the extract to be tested.

2. The method for detecting the yield of Chinese medicine extract according to claim 1, characterized in that: The step of obtaining the yield of the extract to be tested according to the standard relative density of the extract, the weight of the Chinese medicinal material, and the weight and relative density of the extract to be tested comprises: Obtaining the converted weight of the extract to be tested according to the standard relative density of the extract, the weight and relative density of the extract to be tested; The yield of the extract to be tested is obtained according to the converted weight and the weight of the Chinese medicinal material.

3. The method for detecting the yield of Chinese medicine extract according to claim 1, characterized in that: The calculation formula for the converted weight of the extract to be tested is: The calculation formula of the yield of the extract to be tested is: Among them, M 折 is the converted weight of the extract to be tested; M 药 is the weight of the Chinese medicinal material; D 膏 is the relative density of the extract to be tested; D 标 is the standard relative density of the extract; M 膏 is the weight of the extract to be tested.

4. The method for detecting the yield of Chinese medicine extract according to claim 1, characterized in that: The specific method for obtaining the relative density of the extract to be tested comprises the following steps: Weigh the empty specific gravity cup to obtain m1; Weigh the glass cover plate to obtain m2; Weigh the empty specific gravity cup filled with water and covered with a glass cover to obtain m3; Weigh the weight of the empty specific gravity cup after the extract to be tested is put into it to obtain m4; wherein the extract to be tested accounts for 1 / 4 to 1 / 3 of the specific gravity cup; Fill the density cup with water, cover it with a glass lid, and weigh the total weight of the density cup to get m5. Calculate the relative density of the extract to be tested according to the following formula:

5. The method for detecting the yield of Chinese medicine extract according to claim 1, characterized in that: The step of determining the standard relative density of the extract according to the type of the concentrated Chinese medicine pills comprises: According to the type of concentrated Chinese medicine pills, obtain the historical data of the relative density of the corresponding extract within a preset time period; The standard relative density of the extract is determined based on the historical data.

6. A method for producing concentrated Chinese medicine pills, characterized in that: The following steps are involved: Prepare Chinese medicinal materials into Chinese medicinal extracts; The Chinese medicine extract is used as the extract to be tested, and the Chinese medicine extract is tested using the detection method described in any one of claims 1 to 5 to obtain the yield of the Chinese medicine extract.

7. The production method according to claim 6, characterized in that: Also includes: According to the yield of the Chinese medicine extract, the amount of the wetting agent used in the pill making step and the weight of the wet pills obtained are determined.

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