Liposome drug structure detection device and method

Abstract

The invention belongs to the field of liposome drug structure detection, and particularly relates to a liposome drug structure detection device and method.The liposome drug structure detection device comprises a detection table body and a mounting mechanism arranged on the detection table body, and the mounting mechanism comprises a sliding assembly and a protection assembly; the sliding assembly comprises a sliding groove, a threaded rod, a sliding rail support, a threaded shaft, a connecting block, a supporting shaft, a mounting shell and a detection lens, the sliding groove is formed in the rear side wall of the detection table body, the threaded rod is mounted in the sliding groove, and the sliding rail support is mounted on the outer surface of the threaded rod; the reciprocating screw rod is driven by the motor to rotate, the scraping plate and the cleaning shell slide on the sliding rod to a certain extent through the reciprocating screw rod, then the scraping plate and the cleaning shell form an elastic structure through the connecting spring, the elastic structure is tightly attached to the detection table body, and the scraping plate slides in the detection table body. Scraping of the to-be-detected material is effectively promoted, and cleaning and using are convenient.

Description

Technical Field

[0001] The invention relates to the field of structure detection of liposome drugs, in particular to a device and method for structure detection of liposome drugs. Background Art

[0002] Liposomes are nanovesicles with a bilayer structure formed by the self-assembly of phospholipids or phospholipid-like molecules. Because of their superior properties such as in vivo degradability, low immunogenicity, protection of drug active groups, and extended drug half-life, liposomes are widely used in drug delivery and gene therapy. Typical liposome drug products include anti-tumor drugs such as doxorubicin liposomes and irinotecan liposomes, as well as anti-infective drugs such as amphotericin B liposomes. Although China started relatively late in the research of lipid-delivered drugs, it has developed rapidly. More and more pharmaceutical companies and related R&D units are committed to the research and industrial production of lipid nanopharmaceutical preparations.

[0003] Therefore, when existing liposome detection equipment detects the morphology, particle size and distribution of liposomes, it is necessary to manually scrape the liposomes to be detected to facilitate subsequent laser scanning measurement. Manual operation alone may result in inadequate scraping, which affects the detection effect. It is necessary to develop a structural detection device and method for liposome drugs with new functions. Summary of the invention

[0004] The purpose of this section is to summarize some aspects of embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the specification abstract and the invention title of this application to avoid blurring the purpose of this section, the specification abstract and the invention title, and such simplifications or omissions cannot be used to limit the scope of the present invention.

[0005] Therefore, the technical problem to be solved by the present invention is that when the existing liposome detection equipment detects the morphology, particle size and distribution of liposomes, it is necessary to manually scrape the liposomes to be detected to facilitate subsequent laser scanning measurement. It is easy for the scraping to not be in place if it only relies on manual operation, thus affecting the detection effect.

[0006] In order to solve the above technical problems, the present invention provides the following technical solutions: a structure detection device for liposome drugs, comprising a detection platform body and a mounting mechanism arranged on the detection platform body, wherein the mounting mechanism comprises a sliding component and a protection component;

[0007] The sliding assembly comprises a slide groove, a threaded rod, a slide rail bracket, a threaded shaft, a connecting block, a support shaft, a mounting shell and a detection lens, the rear side wall of the detection platform body is provided with a slide groove, a threaded rod is installed inside the slide groove, a slide rail bracket is installed on the outer surface of the threaded rod, a threaded shaft is installed inside the slide rail bracket, a connecting block is installed on the outer surface of the threaded shaft, a support shaft is installed at the front end of the connecting block, a mounting shell is installed on the outer surface of the support shaft, and a detection lens is installed inside the mounting shell;

[0008] The protection assembly includes an adjustment mechanism, a support rod, and a protection mechanism. The support rod is installed at the edge of the upper end surface of the detection platform body, the end of the support rod is installed with the protection mechanism, and the side wall of the installation shell is installed with the adjustment mechanism.

[0009] As a preferred embodiment of the structure detection device and method of liposome drugs described in the present invention, a cleaning mechanism is installed inside the detection platform body, a collecting mechanism is installed on the right side wall of the detection platform body, and an operation panel is arranged above the protection mechanism.

[0010] As a preferred solution of the structure detection device of a liposome drug described in the present invention, the slide rail bracket forms a sliding structure with the detection platform body through a slide groove and a threaded rod, and the connecting block forms a lifting structure with the slide rail bracket through a threaded shaft.

[0011] As a preferred solution of the structure detection device of a liposome drug described in the present invention, the adjustment mechanism includes a first rotating shaft, an electric push rod and a second rotating shaft, the first rotating shaft is installed on the side wall of the mounting shell, the electric push rod is installed inside the first rotating shaft, and the second rotating shaft is installed at the end of the electric push rod.

[0012] As a preferred solution of the structure detection device of a liposome drug described in the present invention, the protection mechanism includes a storage shell, a connecting shaft and a baffle, the upper end of the support rod is installed with the storage shell, the front end surface of the storage shell is installed with the connecting shaft, and the outer surface of the connecting shaft is installed with the baffle.

[0013] As a preferred solution of the structure detection device and method of a liposome drug described in the present invention, the operation panel includes measured data, constructed model, scattering curve and distribution function 1304.

[0014] As a preferred embodiment of the structure detection device of a liposome drug described in the present invention, the cleaning mechanism includes a reciprocating screw, a slider, a cleaning shell, a sliding rod, a connecting spring and a scraper. A reciprocating screw is installed inside the front end of the detection platform body, a sliding rod is installed on the outer surface of the reciprocating screw, a cleaning shell is installed on the inner wall of the sliding rod, a sliding rod is installed at the end of the cleaning shell, a connecting spring is installed inside the cleaning shell, and a scraper is installed at the end of the connecting spring.

[0015] As a preferred solution of the structure detection device of a liposome drug described in the present invention, the scraper forms an elastic structure with the cleaning shell through a connecting spring, and the scraper and the cleaning shell form a sliding structure through a reciprocating screw rod and a sliding rod.

[0016] As a preferred solution of the structure detection device of a liposome drug described in the present invention, the collection mechanism includes a card slot, a card block, a collection shell and a discharge hole, the right side wall of the detection platform body is provided with a discharge hole, the right side wall of the detection platform body is located below the discharge hole and is provided with a card slot, a card block is installed inside the card slot, and the collection shell is installed at the end of the card block.

[0017] The method for detecting the structure of a liposome drug comprises the following steps:

[0018] Step 1: The threaded rod is driven by a motor to slide the rail bracket along the inside of the slide groove, so as to adjust the detection lens installed inside the shell, and is used to adjust the position of the liposome material on the main body of the detection platform for detection. When the threaded shaft is rotated, the height of the detection lens is adjusted. The detection lens adopts dynamic light scattering technology to measure the change of scattered light intensity over time to study the particle diffusion coefficient and particle size distribution. The measurement result will be affected by the height of the instrument. Therefore, when using the light scattering instrument for measurement, the height of the instrument needs to be adjusted according to the experimental requirements and sample characteristics to obtain more accurate measurement results.

[0019] Step 2: The operation panel is set up to actually act on the detection lens, and then the measured data is used to obtain the measured scattering data of the liposome drug, and then a model is constructed for liposome structure model construction, including multiple membrane layers, and the scattering density distribution function of each membrane layer is a Gaussian function. The parameters of the scattering density distribution function of each membrane layer are used as the parameters to be fitted of the structural model, and then the scattering curve and the distribution function are used to fit the theoretical scattering curve according to the measured scattering data to obtain the parameters to be fitted and the scattering density distribution function.

[0020] Step 3: The motor drives the reciprocating screw to rotate, so that the scraper and the cleaning shell can slide on the reciprocating screw and the slide rod. Then the scraper forms an elastic structure with the cleaning shell through the connecting spring, and fits tightly with the main body of the test bench, so that the scraper can slide inside the main body of the test bench, effectively improving the scraping of the material to be tested and facilitating cleaning and use.

[0021] The present invention has the following beneficial effects:

[0022] The present invention achieves a rotation effect of the detection lens inside the installation shell on the support shaft through the rotation effect of the first rotating shaft and the electric push rod, and then the electric push rod rotates through the second rotating shaft and the connecting block, so as to realize the lateral adjustment of the detection lens inside the installation shell, and realize the storage of the installation shell and the detection lens inside the storage shell, so as to effectively prevent dust, splashes or dust from entering the lens, reduce the pollution of the probe surface, and protect the equipment to a certain extent.

[0023] The present invention drives the reciprocating screw to rotate through the motor, so that the scraper and the cleaning shell can slide on the reciprocating screw and the slide rod to a certain extent. Then the scraper forms an elastic structure with the cleaning shell through the connecting spring, and fits tightly with the main body of the detection platform, so that the scraper can slide inside the main body of the detection platform, effectively improves the scraping of the material to be detected, and is convenient for cleaning and use.

[0024] The present invention drives the slide rail bracket along the inside of the slide groove by means of a threaded rod, thereby adjusting the detection lens installed inside the housing, and adjusting the position of the liposome material on the detection platform body to perform detection. When the threaded shaft is rotated, the height of the detection lens is adjusted. The detection lens adopts dynamic light scattering technology to measure the change of scattered light intensity over time to study the particle diffusion coefficient and particle size distribution. The measurement result will be affected by the height of the instrument. Therefore, when using the light scattering instrument for measurement, the height of the instrument needs to be adjusted according to the experimental requirements and the characteristics of the sample to obtain more accurate measurement results. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative labor. Among them:

[0026] Figure 1It is a schematic diagram of the overall structure of the testing platform.

[0027] Figure 2 Schematic diagram of the internal structure of the slide rail bracket.

[0028] Figure 3 This is a schematic diagram of the protection mechanism.

[0029] Figure 4 Schematic diagram of the internal structure of the test bench body.

[0030] Figure 5 Schematic diagram of the structure for cleaning the shell.

[0031] Figure 6 It is a schematic diagram of the side view structure of the main body of the testing platform.

[0032] Figure 7 It is a structural diagram of the operation panel process.

[0033] In the figure: 1. Main body of the test bench; 2. Slide groove; 3. Threaded rod; 4. Slide rail bracket; 5. Threaded shaft; 6. Connecting block; 7. Support shaft; 8. Mounting shell; 9. Test lens; 10. Adjustment mechanism; 1001. First rotating shaft; 1002. Electric push rod; 1003. Second rotating shaft; 11. Support rod; 12. Protection mechanism; 1201. Storage shell; 1202. Connecting shaft; 1203. Baffle; 13. Operation Panel; 1301, measured data; 1302, model building; 1303, scattering curve; 1304, distribution function; 14, cleaning mechanism; 1401, reciprocating screw; 1402, slider; 1403, cleaning shell; 1404, slide bar; 1405, connecting spring; 1406, scraper; 15, collecting mechanism; 1501, slot; 1502, block; 1503, collecting shell; 1504, discharge hole DETAILED DESCRIPTION

[0034] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the accompanying drawings.

[0035] Example 1

[0036] The first embodiment of the present invention provides a structure detection device for liposome drugs, a detection platform body 1 and a mounting mechanism arranged on the detection platform body 1, wherein the mounting mechanism includes a sliding component and a protective component;

[0037] The sliding assembly includes a slide groove 2, a threaded rod 3, a slide rail bracket 4, a threaded shaft 5, a connecting block 6, a support shaft 7, a mounting shell 8 and a detection lens 9. The rear side wall of the detection platform body 1 is provided with a slide groove 2, the threaded rod 3 is installed inside the slide groove 2, the slide rail bracket 4 is installed on the outer surface of the threaded rod 3, the threaded shaft 5 is installed inside the slide rail bracket 4, the connecting block 6 is installed on the outer surface of the threaded shaft 5, the supporting shaft 7 is installed at the front end of the connecting block 6, the mounting shell 8 is installed on the outer surface of the supporting shaft 7, and the detection lens 9 is installed inside the mounting shell 8;

[0038] The protection assembly includes an adjustment mechanism 10, a support rod 11, and a protection mechanism 12. The support rod 11 is installed at the edge of the upper end surface of the detection platform body 1, the protection mechanism 12 is installed at the end of the support rod 11, and the adjustment mechanism 10 is installed on the side wall of the mounting shell 8.

[0039] The slide rail bracket 4 forms a sliding structure with the detection platform body 1 through the slide groove 2 and the threaded rod 3, and the connecting block 6 forms a lifting structure with the slide rail bracket 4 through the threaded shaft 5. The set threaded rod 3 is driven by the motor, and then the slide rail bracket 4 is slid along the inside of the slide groove 2 to achieve the adjustment of the detection lens 9 inside the installation shell 8, which is used to adjust the position of the liposome material on the detection platform body 1 for detection. Then, when the threaded shaft 5 rotates, the height of the detection lens 9 is adjusted, and the detection lens 9 adopts dynamic light scattering technology to measure the change of scattered light intensity over time to study the particle diffusion coefficient and particle size distribution. The measurement result will be affected by the height of the instrument. Therefore, when using the light scattering instrument for measurement, it is necessary to adjust the instrument height according to the experimental requirements and sample characteristics to obtain more accurate measurement results.

[0040] The adjusting mechanism 10 includes a first rotating shaft 1001, an electric push rod 1002 and a second rotating shaft 1003. The first rotating shaft 1001 is installed on the side wall of the mounting shell 8, the electric push rod 1002 is installed inside the first rotating shaft 1001, and the second rotating shaft 1003 is installed at the end of the electric push rod 1002. The electric push rod 1002 is set to perform a certain telescopic effect, and then the mounting shell 8 is rotated through the first rotating shaft 1001 and the electric push rod 1002, and then the electric push rod 1002 is rotated through the second rotating shaft 1003 and the connecting block 6, so that the detection lens 9 inside the mounting shell 8 can be rotated on the support shaft 7, thereby realizing the lateral adjustment of the detection lens 9 inside the mounting shell 8.

[0041] The protection mechanism 12 includes a storage shell 1201 , a connecting shaft 1202 and a baffle 1203 . The storage shell 1201 is installed on the upper end of the support rod 11 , the connecting shaft 1202 is installed on the front end surface of the storage shell 1201 , and the baffle 1203 is installed on the outer surface of the connecting shaft 1202 .

[0042] When the detection lens 9 completes the detection work, the threaded rod 3 slides to the right end of the detection platform body 1, and the baffle 1203 is lifted upward through the connecting shaft 1202, and then the set electric push rod 1002 performs a certain telescopic effect, and then the installation shell 8 is installed through the rotation of the first rotating shaft 1001 and the electric push rod 1002, and then the electric push rod 1002 is installed through the second rotating shaft 1003 and the connecting block 6. The detection lens 9 inside the installation shell 8 is rotated on the support shaft 7, and the detection lens 9 inside the installation shell 8 is adjusted laterally, so that the installation shell 8 and the detection lens 9 are stored inside the storage shell 1201, which effectively prevents dust, droplets or dust from entering the lens, reduces the pollution of the probe surface, and protects the equipment to a certain extent.

[0043] Example 2

[0044] This embodiment is based on the previous embodiment, and is different from the previous embodiment in that this embodiment provides a structure detection device for liposome drugs. Specifically.

[0045] A cleaning mechanism 14 is installed inside the detection platform body 1 , a collecting mechanism 15 is installed on the right side wall of the detection platform body 1 , and an operation panel 13 is arranged above the protection mechanism 12 .

[0046] The operation panel 13 includes measured data 1301, a constructed model 1302, a scattering curve 1303 and a distribution function 1304. The set operation panel 13 is used to actually operate the detection lens 9. Then the measured data 1301 obtains the measured scattering data of the liposome drug. Then the constructed model 1302 is used to construct the liposome structure model, including multiple membrane layers. The scattering density distribution function 1304 of each membrane layer is a Gaussian function. The parameters of the scattering density distribution function 1304 of each membrane layer are used as parameters to be fitted for the structural model. Then the scattering curve 1303 and the distribution function 1304 are used to fit the theoretical scattering curve 1303 according to the measured scattering data to obtain the parameters to be fitted and the scattering density distribution function 1304.

[0047] The cleaning mechanism 14 includes a reciprocating screw 1401, a slider 1402, a cleaning shell 1403, a slide bar 1404, a connecting spring 1405 and a scraper 1406. The reciprocating screw 1401 is installed inside the front end of the detection platform body 1, the slider 1402 is installed on the outer surface of the reciprocating screw 1401, the cleaning shell 1403 is installed on the inner wall of the slider 1402, the slide bar 1404 is installed at the end of the cleaning shell 1403, the connecting spring 1405 is installed inside the cleaning shell 1403, and the scraper 1406 is installed at the end of the connecting spring 1405.

[0048] The scraper 1406 forms an elastic structure with the cleaning shell 1403 through the connecting spring 1405, and the scraper 1406 and the cleaning shell 1403 form a sliding structure through the reciprocating screw 1401 and the slide bar 1404. The reciprocating screw 1401 is driven by the motor to rotate, so that the scraper 1406 and the cleaning shell 1403 can slide on the reciprocating screw 1401 and the slide bar 1404 to a certain extent. Then, the scraper 1406 forms an elastic structure with the cleaning shell 1403 through the connecting spring 1405, and fits tightly on the detection platform body 1, so that the scraper 1406 can slide inside the detection platform body 1, effectively improving the scraping of the material to be detected, and facilitating cleaning and use.

[0049] The collecting mechanism 15 includes a card slot 1501, a card block 1502, a collecting shell 1503 and a discharge hole 1504. The right side wall of the detection platform body 1 is provided with a discharge hole 1504. The right side wall of the detection platform body 1 is located below the discharge hole 1504 and is provided with a card slot 1501. The card block 1502 is installed inside the card slot 1501. The end of the card block 1502 is installed with a collecting shell 1503. The scraped detection material reaches the discharge hole 1504 and then is collected and concentrated by the collecting shell 1503.

[0050] Working principle: First, the threaded rod 3 is driven by the motor, and then the slide rail bracket 4 is slid along the inside of the slide groove 2 to adjust the detection lens 9 inside the mounting shell 8, which is used to adjust the position of the liposome material on the detection platform body 1 for detection. Then, when the threaded shaft 5 rotates, the height of the detection lens 9 is adjusted. The detection lens 9 uses dynamic light scattering technology to measure the change of scattered light intensity over time to study the particle diffusion coefficient and particle size distribution. The measurement result will be affected by the height of the instrument. Therefore, when using the light scattering instrument for measurement, the instrument height needs to be adjusted according to the experimental requirements and sample characteristics to obtain more accurate measurement results.

[0051] Then, the set operation panel 13 is used to actually act on the detection lens 9, and then the measured data 1301 obtains the measured scattering data of the liposome drug, and then the model 1302 is constructed for liposome structure model construction, including multiple membrane layers, and the scattering density distribution function 1304 of each membrane layer is a Gaussian function, and the parameters of the scattering density distribution function 1304 of each membrane layer are used as parameters to be fitted of the structural model, and then the scattering curve 1303 and the distribution function 1304 are used to fit the theoretical scattering curve 1303 according to the measured scattering data to obtain the parameters to be fitted and the scattering density distribution function 1304.

[0052] Finally, the motor drives the reciprocating screw 1401 to rotate, so that the scraper 1406 and the cleaning shell 1403 can slide on the reciprocating screw 1401 and the slide rod 1404. Then the scraper 1406 forms an elastic structure with the cleaning shell 1403 through the connecting spring 1405, and fits tightly on the detection platform body 1, so that the scraper 1406 can slide inside the detection platform body 1, effectively improving the scraping of the material to be detected, and facilitating cleaning and use.

Claims

1. A structure detection device for liposome drugs, characterized in that: It comprises a detection platform body (1) and a mounting mechanism arranged on the detection platform body (1), wherein the mounting mechanism comprises a sliding component and a protective component; The sliding assembly comprises a slide groove (2), a threaded rod (3), a slide rail bracket (4), a threaded shaft (5), a connecting block (6), a support shaft (7), a mounting shell (8) and a detection lens (9); a slide groove (2) is provided on the rear side wall of the detection platform body (1); a threaded rod (3) is installed inside the slide groove (2); a slide rail bracket (4) is installed on the outer surface of the threaded rod (3); a threaded shaft (5) is installed inside the slide rail bracket (4); a connecting block (6) is installed on the outer surface of the threaded shaft (5); a supporting shaft (7) is installed at the front end of the connecting block (6); a mounting shell (8) is installed on the outer surface of the support shaft (7); and a detection lens (9) is installed inside the mounting shell (8); The protection assembly comprises an adjustment mechanism (10), a support rod (11), and a protection mechanism (12); the support rod (11) is installed at the edge of the upper end surface of the detection platform body (1); the protection mechanism (12) is installed at the end of the support rod (11); and the adjustment mechanism (10) is installed on the side wall of the installation shell (8).

2. The structure detection device of a liposome drug according to claim 1, characterized in that: A cleaning mechanism (14) is installed inside the detection platform body (1), a collecting mechanism (15) is installed on the right side wall of the detection platform body (1), and an operating panel (13) is arranged above the protection mechanism (12).

3. The structure detection device of a liposome drug according to claim 1, characterized in that: The slide rail bracket (4) forms a sliding structure with the detection platform body (1) through the slide groove (2) and the threaded rod (3), and the connection block (6) forms a lifting structure with the slide rail bracket (4) through the threaded shaft (5).

4. The structure detection device and method of a liposome drug according to claim 1, characterized in that: The adjusting mechanism (10) comprises a first rotating shaft (1001), an electric push rod (1002) and a second rotating shaft (1003); the first rotating shaft (1001) is installed on the side wall of the mounting housing (8); the electric push rod (1002) is installed inside the first rotating shaft (1001); and the second rotating shaft (1003) is installed at the end of the electric push rod (1002).

5. The structure detection device of a liposome drug according to claim 1, characterized in that: The protection mechanism (12) comprises a storage shell (1201), a connecting shaft (1202) and a baffle (1203); the storage shell (1201) is installed at the upper end of the support rod (11); the connecting shaft (1202) is installed at the front end surface of the storage shell (1201); and the baffle (1203) is installed on the outer surface of the connecting shaft (1202).

6. A liposome drug structure detection device as claimed in claim 2, characterized in that: The operation panel (13) includes measured data (1301), a constructed model (1302), a scattering curve (1303) and a distribution function (1304).

7. A liposome drug structure detection device as claimed in claim 2, characterized in that: The cleaning mechanism (14) comprises a reciprocating screw (1401), a slider (1402), a cleaning shell (1403), a slide bar (1404), a connecting spring (1405) and a scraper (1406); the reciprocating screw (1401) is installed inside the front end of the detection platform body (1); the slide bar (1402) is installed on the outer surface of the reciprocating screw (1401); the cleaning shell (1403) is installed on the inner wall of the slide bar (1402); the slide bar (1404) is installed at the end of the cleaning shell (1403); the connecting spring (1405) is installed inside the cleaning shell (1403); and the scraper (1406) is installed at the end of the connecting spring (1405).

8. A liposome drug structure detection device as claimed in claim 7, characterized in that: The scraper (1406) forms an elastic structure with the cleaning shell (1403) through the connecting spring (1405), and the scraper (1406) and the cleaning shell (1403) form a sliding structure through the reciprocating screw rod (1401) and the sliding rod (1404).

9. A liposome drug structure detection device as claimed in claim 2, characterized in that: The collecting mechanism (15) comprises a card slot (1501), a card block (1502), a collecting shell (1503) and a discharge hole (1504); the right side wall of the detection platform body (1) is provided with a discharge hole (1504); the right side wall of the detection platform body (1) is provided with a card slot (1501) below the discharge hole (1504); the card block (1502) is installed inside the card slot (1501); and the collecting shell (1503) is installed at the end of the card block (1502).

10. The method for detecting the structure of a liposome drug according to claim 1, characterized in that: The steps include: Step 1: The threaded rod (3) is driven by a motor to slide the rail bracket (4) along the inside of the slide groove (2) to adjust the detection lens (9) inside the mounting shell (8) to adjust the position of the liposome material on the detection platform body (1) for detection. When the threaded shaft 5 rotates, the height of the detection lens (9) is adjusted. The detection lens (9) uses dynamic light scattering technology to measure the change of scattered light intensity over time to study the particle diffusion coefficient and particle size distribution. The measurement result will be affected by the height of the instrument. Therefore, when using a light scattering instrument for measurement, the height of the instrument needs to be adjusted according to the experimental requirements and sample characteristics to obtain more accurate measurement results. Step 2: The operation panel (13) is set up to actually operate the detection lens (9), and then the measured data (1301) is used to obtain the measured scattering data of the liposome drug, and then a model (1302) is constructed for liposome structure model construction, including multiple membrane layers, and the scattering density distribution function 1304 of each membrane layer is a Gaussian function, and the parameters of the scattering density distribution function 1304 of each membrane layer are used as the parameters to be fitted of the structure model, and then the scattering curve (1303) and the distribution function (1304) are used to fit the theoretical scattering curve according to the measured scattering data to obtain the parameters to be fitted and the scattering density distribution function (1304). Step 3: The reciprocating screw (1401) is driven by a motor to rotate, so that the scraper (1406) and the cleaning shell (1403) can slide on the reciprocating screw (1401) and the slide bar (1404). Then, the scraper (1406) forms an elastic structure with the cleaning shell (1403) through the connecting spring (1405), and fits tightly on the detection platform body 1, so that the scraper (1406) can slide inside the detection platform body (1), effectively improving the scraping of the material to be detected, and facilitating cleaning and use.

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