Buttock cream and preparation method thereof

Abstract

The invention belongs to the field of cosmetics, and discloses a hip cream, which comprises the following components by weight: 44-57.5% of petrolatum; 35%-45% of light polar synthetic grease; 3-8% of wool fat; 2 to 5 percent of trihydroxy stearin; 1-5% of microcrystalline wax; 1-3% of oil absorption powder; and 0.5-2% of white beeswax. According to the diaper rash cream disclosed by the invention, petrolatum is taken as a main component, light polar synthetic grease, wool fat, trihydroxy stearin, microcrystalline wax and cera alba are taken as auxiliary components, and the six components are matched, so that the forming capability of an isolating layer and the hardness support during temperature change are remarkably improved, and a better urine isolating effect is realized. Meanwhile, the invention further provides a preparation method of the hip cream.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and specifically to a buttock cream and a preparation method thereof. Background Art

[0002] Baby red buttocks, also known as diaper rash or diaper dermatitis in medicine, are mainly caused by damage to the buttocks skin resulting in redness of the small buttocks, or secondary infections by microorganisms such as bacteria and fungi on the damaged skin, which exacerbate the degree of red buttocks.

[0003] The main function of the buttock cream is to prevent baby red buttocks. By applying an appropriate amount of the buttock cream to the baby's buttocks, a protective film will be formed to play an isolation role. Therefore, the isolation performance is the primary performance to be considered for the buttock cream.

[0004] The following can be referred to for the literature on buttock cream:

[0005] A patent application with the publication number CN112263527A and the theme of an infant buttock cream and a preparation method thereof;

[0006] A patent application with the publication number CN112315860A and the theme of a traditional Chinese medicine system infant buttock cream and a preparation method thereof;

[0007] A patent application with the publication number CN110638727A and the theme of an infant buttock composition and a preparation method and application thereof;

[0008] A patent application with the publication number CN110302121A and the theme of an infant buttock cream containing plant essence and a preparation method thereof. The disclosed formula is: 60-90 parts of petrolatum, 5-15 parts of liquid paraffin, 2-10 parts of microcrystalline wax, 2-10 parts of camellia seed oil, 3-8 parts of zinc oxide, 0.1-1 part of antioxidant, 0.1-1 part of bisabolol, 1-5 parts of evening primrose oil, 0.01-1 part of olive fruit extract, 0.01-1 part of water.

[0009] A patent application with the publication number CN103027871A and the theme of an infant buttock cream. The disclosed formula includes 55-78% of petrolatum, 3-7% of aloe extract essence, 10-15% of sterilized deionized water, 2-4% of microcrystalline wax, 3-7% of loofah extract essence, 1-3% of polyglycerol-3 stearate, 1-3% of vitamin E, 1-3% of propylparaben, 1-3% of methylparaben.

[0010] Among them, CN110302121A and CN103027871A are formulas with petrolatum as the main component. In the above-mentioned schemes, in addition to petrolatum as the main component, other oils are also used, such as liquid paraffin, microcrystalline wax, polyglycerol-3 stearate, etc.

[0011] In the research, it is found that constructing a stable isolation layer that can effectively provide hardness support during temperature change cannot be fully achieved only by petrolatum.

[0012] Therefore, the core problem and requirement of this case are: how to optimize the existing diaper rash cream, improve the forming ability of the isolation layer constructed by the diaper rash cream and the hardness support during temperature change, and achieve a better urine isolation effect. Summary of the Invention

[0013] The purpose of the present invention is to provide a diaper rash cream. The diaper rash cream of the present invention takes petrolatum as the main component, and uses light polar synthetic grease, lanolin, tripalmitin, microcrystalline wax, and white beeswax as auxiliary components. The six are combined to significantly improve the forming ability of the isolation layer and the hardness support during temperature change, and achieve a better urine isolation effect.

[0014] At the same time, the present invention also provides a preparation method of the diaper rash cream.

[0015] To achieve the above purpose, the present invention provides the following technical solutions:

[0016] A diaper rash cream, comprising the following components in percentage by weight:

[0017] Petrolatum: 44-57.5%;

[0018] Light polar synthetic grease: 35-45%;

[0019] Lanolin: 3-8%;

[0020] Tripalmitin: 2-5%;

[0021] Microcrystalline wax: 1-5%;

[0022] Oil-absorbing powder: 1-3%;

[0023] White beeswax: 0.5-2%.

[0024] The functions and cooperation mechanisms of the above components are as follows:

[0025] Petrolatum: Petrolatum is a common skin care ingredient, which has the functions of moisturizing, nourishing, and protecting the skin barrier. Petrolatum can form a protective film on the skin surface, isolate and reduce the damage of external irritants to the skin.

[0026] Light polar synthetic oils and fats: Taking ethylhexyl stearate and triglyceride caprylate / caprate as examples, both are excellent emollients and moisturizers. On the one hand, they can bring a smooth and delicate skin feel, making the diaper rash cream easier to spread and leaving no greasy or sticky feeling on the skin. On the other hand, ethylhexyl stearate has good permeability, which can help the active ingredients in the diaper rash cream better penetrate into the deep layer of the skin, thus exerting better effects. Moreover, ethylhexyl stearate can also be used as a solvent and carrier to help other ingredients in the diaper rash cream better disperse and dissolve evenly, enhancing stability and uniformity and improving the isolation effect.

[0027] Lanolin: The oil compounds contained in lanolin can adhere to the skin surface to form a protective film, reducing the damage of external irritants to the skin. At the same time, the fatty acids, phospholipids and other components contained in lanolin can accelerate cell regeneration and repair, and improve the healing speed.

[0028] Trimethylolpropane tristearate: It is a thickening agent, suspending agent and dispersing agent formed by hydrogenation and oxidation of castor oil, with a long carbon chain glyceride structure. It forms a three-dimensional network structure through intermolecular non-covalent bonds to stabilize the formula. Trimethylolpropane tristearate has good compatibility with the two main components of petrolatum and light polar synthetic oils and fats, and can form a crystalline molecular network structure, which is less affected by the oils and fats. Under high temperature shear, the molecules of trimethylolpropane tristearate straighten and stretch to an expanded state, with a large swelling volume, which can suspend petrolatum, light polar synthetic oils and fats and other components, so that it is stable and does not delaminate at high temperature, maintaining the texture and softness and hardness of the paste.

[0029] Microcrystalline wax: Microcrystalline wax is a refined synthetic wax with an approximate microcrystalline nature, characterized by good gloss, high melting point and light color. It can also be used as the wax base of the product to provide good texture and stability. Microcrystalline wax has good oil absorption performance, can form a stable and uniform paste with a variety of solvents and waxes, has good adhesion and ductility, is not brittle at low temperature, and can prevent oil from separating out when added to liquid oil, maintaining the softness and hardness of the paste.

[0030] Oil-absorbing powder: Taking starch aluminum octenyl succinate as an example, after adding an appropriate amount of starch aluminum octenyl succinate to the diaper rash cream, the greasiness caused by the oil components can be significantly reduced, giving the skin a soft and smooth feeling, improving the skin feel of the product. At the same time, the dispersed pore structure can improve the air permeability, so that when using the diaper rash cream, it can isolate and does not make the baby's bottom stuffy and red.

[0031] White beeswax: White beeswax can build a moisturizing barrier on the skin surface, deeply nourish to achieve a moisturizing effect; for damaged skin, white beeswax provides soothing and repair, antibacterial and anti-inflammatory to reduce sensitive symptoms, and helps treat diaper rash. The change of temperature has little impact on natural beeswax, and it will not deteriorate at higher temperatures, which can effectively protect the active ingredients in cosmetics. White beeswax can be used as the matrix of ointment, providing good emulsification and thickening effects, improving the texture, viscosity and permeability of diaper cream, helping the ingredients to be evenly dispersed, and making the product easy to apply and absorb.

[0032] From the perspectives of urine isolation and high and low temperature performance, the synergistic cooperation mechanism among the above components is as follows: Lanolin raw material itself has a certain viscosity. It is speculated that when it comes into contact with urine, it can immediately fix the liquid droplets and slow down the diffusion speed of the liquid droplets. However, lanolin itself has relatively good water absorption. Over time, it will absorb urine and affect the urine isolation effect. As the addition amount increases, its water absorption will also increase, which will instead affect the long-term urine isolation effect of the diaper cream. Utilizing the raw material characteristics of lanolin itself can assist in improving the urine isolation performance; Trihydroxystearin can form a crystalline molecular network structure with petrolatum and ethylhexyl stearate, which helps to stabilize the compatibility of each component and ensure the uniformity of the film formation of the diaper cream. Under high-temperature shear, the molecules straighten and expand into a swollen state, with a large swelling volume, which can well suspend the light synthetic grease and lanolin with a relatively low melting point, ensuring the lasting performance of the film. Considering the high-humidity and high-stuffiness scenario of infants using diapers for a long time and the need to improve the urine isolation performance in high-temperature situations, it is necessary to add trihydroxystearin. In addition, microcrystalline wax and white beeswax can form a stable and uniform paste with light polar synthetic grease, petrolatum and other active ingredients, having good adhesiveness and ductility, which is helpful for the uniformity and persistence of the film formation of the diaper cream and can synergistically enhance the urine isolation performance.

[0033] Judging from the verification of different cases of the present invention, each formula has significant advantages in at least one of urine isolation performance, high-temperature performance and low-temperature performance compared with the comparative cases.

[0034] In the above diaper cream, it includes the following components in weight percentage:

[0035] Petrolatum: 44.7 - 54%;

[0036] Light polar synthetic grease: 35 - 45%;

[0037] Lanolin: 3 - 8%;

[0038] Trihydroxystearin: 2 - 3%;

[0039] Microcrystalline wax: 1 - 1.5%;

[0040] Oil-absorbing powder: 1 - 1.5%;

[0041] White beeswax: 0.5 - 1%.

[0042] From the verification of different cases of the present invention, the urine-proof performance and high-temperature performance of the above-mentioned preferred formula have significant advantages compared with the comparative cases.

[0043] In the above-mentioned diaper rash cream, it also includes 0.1 - 1% of macadamia nut oil.

[0044] Note: Unless otherwise specified, the % in the present invention is by weight.

[0045] Macadamia nut oil: Also known as macadamia oil, the seeds are dark yellow, and the dry kernel contains 75% - 79% of oil by mass. Macadamia nut oil is the only natural vegetable oil containing a large amount of palmitoleic acid. Its fatty acid composition is similar to that of human sebum, and it has high stability without the need to add antioxidants. It has a high dispersion coefficient and skin permeability. Adding macadamia nut oil to the diaper rash cream can increase the lubricity and nourishment, with better extensibility, making the film-forming more uniform, improving the isolation effect. At the same time, macadamia nut oil has a healing and soothing effect, which can accelerate the repair of red buttocks.

[0046] In the above-mentioned diaper rash cream, the light polar synthetic oil is ethylhexyl stearate and / or triglyceride caprylate / caprate.

[0047] In the above-mentioned diaper rash cream, the oil-absorbing powder is aluminum starch octenyl succinate and / or boron nitride.

[0048] In the above-mentioned diaper rash cream, it also includes a redness-reducing and soothing component; the redness-reducing and soothing component is one or more of stearyl glycyrrhetinate, bisabolol, and centella asiatica leaf extract.

[0049] Of course, in the art, other plant extracts or other functional components with similar functions can also be added to the formula of the present invention to achieve the effect of soothing and reducing redness on the delicate skin of babies.

[0050] In the above-mentioned diaper rash cream, the dosage of the redness-reducing and soothing component is 0.1 - 1.5%.

[0051] In the above-mentioned diaper rash cream, it also includes an active ingredient for inhibiting urease activity; the active ingredient is pomegranate peel extract and / or quercetin; the dosage of the active ingredient is 0.001 - 0.01%.

[0052] As another core innovation point of the present invention, the present invention uses pomegranate peel extract in the formula. It has been reported in the existing literature that pomegranate peel extract can inhibit the activity of urease (Urease);

[0053] Urease is an enzyme that catalyzes the hydrolysis of urea into ammonia and carbon dioxide. It has high specificity and is widely present in microorganisms and animal and plant tissues. It is the first enzyme to be crystallized and proven to be a protein. When urea is hydrolyzed, the generated ammonia is the main component causing redness and irritation of the baby's skin. Inhibiting the activity of urease is another main core means to improve diaper rash on the premise of achieving an improved isolation effect.

[0054] Meanwhile, the present invention also discloses a preparation method of the buttock cream as described in any one of the above, comprising the following steps:

[0055] Step 1: Mix petrolatum, light polar synthetic grease, lanolin, trihydroxystearin, microcrystalline wax, and white beeswax, heat up to melting and homogenize.

[0056] Step 2: Cool down to 55 - 70 °C and stir for homogenization.

[0057] Step 3: Add oil-absorbing powder to Step 2, stir for homogenization, and then cool down and discharge.

[0058] More specifically, the method of the present invention is as follows: Step 1: Under stirring, heat petrolatum, ethylhexyl stearate, lanolin, trihydroxystearin, microcrystalline wax, white beeswax, macadamia nut oil, and stearoyl glycyrrhetinate in the redness-reducing and soothing component to 85 - 95 °C, keep warm for 5 - 20 minutes until completely dissolved, and homogenize to obtain Component A;

[0059] Step 2: Cool down Component A to 55 - 70 °C under stirring and stir for homogenization evenly.

[0060] Step 3: Separately mix other components in the redness-reducing and soothing component such as centella asiatica leaf extract, and active components for inhibiting urease activity such as pomegranate peel extract and water until completely dissolved to obtain Component B;

[0061] Step 4: Stir and cool down to 38 - 48 °C, add Component B and Component C (oil-absorbing powder such as starch octenyl succinate aluminum, and other components in the redness-reducing and soothing component such as bisabolol), stir and homogenize evenly, and stir and cool down to 30 - 38 °C to obtain the buttock cream.

[0062] Compared with the prior art, the beneficial effects of the present invention are:

[0063] The buttock cream of the present invention takes petrolatum as the main component, and uses light polar synthetic grease, lanolin, trihydroxystearin, microcrystalline wax, and white beeswax as auxiliary components. The six are combined to significantly improve the forming ability of the isolation layer and the hardness support during temperature change, achieving a better urine isolation effect;

[0064] In a preferred embodiment of the present invention, pomegranate peel extract is used. We found that pomegranate peel extract can inhibit the activity of urease. By inhibiting the activity of urease, the present invention is another main core means to improve diaper rash on the premise of achieving an improved isolation effect. Description of the Drawings

[0065] Figure 1 It is a contact angle photo of the blank experimental group in the contact angle test;

[0066] Figure 2 It is a contact angle photo of Example 2 in the contact angle test. Detailed Description of the Invention

[0067] Next, the technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope of protection of the present invention.

[0068] Source Description of Raw Materials

[0069] The raw materials used in the present invention can be referred to in Table 1 below;

[0070] Table 1 Raw Material Source Table

[0071]

[0072]

[0073] For the first part, the examples and comparative examples refer to the formula in Table 2 and are prepared according to the following steps:

[0074] Example 1:

[0075] Step 1: Heat mineral oil, ethylhexyl stearate, lanolin, trihydroxystearin, microcrystalline wax, white beeswax, and macadamia nut oil to 85 - 95°C with stirring, keep warm for 5 - 20 minutes until completely dissolved, and homogenize to obtain Component A;

[0076] Step 2: Cool Component A to 55 - 70°C with stirring and homogenize evenly;

[0077] Step 3: Dissolve pomegranate peel extract and water alone and mix them until completely dissolved to obtain Component B;

[0078] Step 4: Cool with stirring to 38 - 48°C, add Component B and Component C (starch octenyl succinate aluminum, bisabolol), homogenize evenly with stirring, and cool with stirring to 30 - 38°C to obtain the diaper rash cream.

[0079] Table 2 Diaper Rash Ointment Formula Table Unit: g

[0080]

[0081]

[0082] The proportions of the redness-reducing and soothing ingredients in the above-mentioned examples and comparative examples can be referred to in Table 3 below;

[0083] Table 3 Redness-Reducing and Soothing Ingredient Formula Table Unit: g

[0084] Stearyl Glycyrrhetinate Bisabolol Centella asiatica leaf extract Example 1 0 0.1 0 Example 2 0.195 0.2 0.1 Example 3 0.5 0 0.5 Example 4 0.33 0.33 0.33 Example 5 0 0.3 0.29 Example 8 0.2 0 0

[0085] Performance Test

[0086] The above samples were tested as follows: immediate urine barrier effect - contact angle test, overall sensory average score, long-acting 4-hour urine barrier effect, high and low temperature performance, soothing and redness-reducing test;

[0087] The specific test methods are as follows:

[0088] Test Item 1: Immediate Urine Barrier Effect - Contact Angle Test

[0089] Test Method:

[0090] Use a pipettor to evenly apply the sample on the pigskin, and smear it with a finger wearing a latex finger cot, and gently and evenly apply the sample on the pigskin in an amount of 25 mg / cm 2 so that there is no residue on the finger cot as much as possible. Then use a ruler or other tool to level the surface horizontally. Leave the smeared pigskin standing in an environment with a temperature of 25.6 °C and a relative humidity of 66% for 5 min. Quantitatively drop artificial urine onto the pigskin and test it with a fully automatic contact angle measuring instrument. Conduct three parallel tests for each sample, and then take the average value.

[0091] Result Explanation

[0092] If the contact angle < 90°, the sample to be tested is hydrophilic; if the contact angle ≥ 90°, the sample to be tested is hydrophobic.

[0093] The test results are shown in Table 4. Among them, the test photos of the blank experimental group (pigskin) can be seen Figure 1 , and the test photos of Example 2 can be seen Figure 2 ;

[0094] Table 4 Contact Angle Test Results

[0095] Sample First time Second time Third time Mean value Blank experimental group (pig skin) 68.40° 67.90° 70.21° 68.84° Example 1 94.78° 94.21° 95.26° 94.75° Example 2 102.67° 101.13° 103.53° 102.44° Example 3 95.21° 96.03° 95.35° 95.53° Example 4 93.45° 93.56° 94.57° 93.86° Example 5 110.32° 113.35° 112.34° 112.00° Example 6 103.67° 101.23° 103.53° 102.81° Example 7 103.13° 101.57° 103.23° 102.64° Example 8 102.22° 102.39° 102.43° 102.35° Comparative Example 1 92.18° 93.34° 92.09° 92.54° Comparative Example 2 94.67° 95.03° 94.34° 94.68° Comparative Example 3 95.02° 95.33° 94.89° 95.08° Comparative Example 4 94.93° 95.31° 95.05° 95.10° Comparative Example 5 93.67° 93.54° 93.55° 93.59°

[0096] Test Item 2: Long-Acting 4-Hour Urine Barrier Effect

[0097] Test Method:

[0098] Apply the diaper rash cream product (0.4 g, which is just enough to cover the filter paper) on the surface of a 1 / 4 filter paper. Place another layer of filter paper underneath. Drop 0.4 g of artificial urine onto the upper filter paper. Observe whether a protective film can be formed on the filter paper to isolate the artificial urine and whether the filter paper coated with the diaper rash cream is wetted after standing for 0 h and 4 h.

[0099] Results show that

[0100] If the filter paper is not wet and shows obvious granular water droplets, it proves that the diaper rash cream product has excellent urine isolation effect; if the filter paper is partially wet with a small amount of water droplets, it proves that the diaper rash cream product has a general urine isolation effect; if the filter paper is wetted and no water droplets are formed, the diaper rash cream product has a poor urine isolation effect; the evaluation results are divided into three levels: excellent, general, and poor.

[0101] The original data results of the urine isolation effect of the diaper rash cream are statistically shown in Table 5;

[0102] Table 5 Test results of the long-acting 4-hour urine isolation effect

[0103] Sample Applied at 0 h Applied at 4 h Evaluation result Example 1 The filter paper was not wetted and water droplets were formed The filter paper was not wetted and the water droplets still existed Excellent Example 2 The filter paper was not wetted and water droplets were formed The filter paper was not wetted and the water droplets still existed Excellent Example 3 The filter paper was not wetted and water droplets were formed The filter paper was not wetted and the water droplets still existed Excellent Example 4 The filter paper was not wetted and water droplets were formed The filter paper was not wetted and the water droplets still existed Excellent Example 5 The filter paper was not wetted and water droplets were formed The filter paper was partially wetted and a small amount of water droplets existed General Example 6 The filter paper was not wetted and water droplets were formed The filter paper was not wetted and the water droplets still existed Excellent Example 7 The filter paper was not wetted and water droplets were formed The filter paper was not wetted and the water droplets still existed Excellent Example 8 The filter paper was not wetted and water droplets were formed The filter paper was not wetted and the water droplets still existed Excellent Comparative Example 1 The filter paper was not wetted and water droplets were formed The filter paper was partially wetted and a small amount of water droplets existed General Comparative Example 2 The filter paper was not wetted and water droplets were formed The filter paper was partially wetted and a small amount of water droplets existed General Comparative Example 3 The filter paper was not wetted and water droplets were formed The filter paper was partially wetted and a small amount of water droplets existed General Comparative Example 4 The filter paper was not wetted and water droplets were formed The filter paper was partially wetted and a small amount of water droplets existed General Comparative Example 5 The filter paper was not wetted and water droplets were formed The filter paper was partially wetted and a small amount of water droplets existed General

[0104] Test item 3: Sensory evaluation

[0105] Test method

[0106] Adopt the method of sensory evaluation by testers. Take 0.1 mg of the diaper rash cream and evenly apply it on a 5.0 cm x 5.0 cm square area on the inner side of the tester's (not less than 5) arm. Sensory evaluate the load feeling on the skin and score it from 1 to 10. 10 points means that the skin feels very light and easy to spread, without oiliness, stickiness or burden. Take the average value of the testers. The test results are shown in Table 6;

[0107] Table 6 Test results of sensory evaluation

[0108]

[0109] Test item 4: Low-temperature hardness performance test

[0110] Test method

[0111] Fill the diaper rash cream sample into the same packaging material, then place it in a refrigerator at a temperature of 4 ± 1 °C. After 48 hours, take out the sample and observe the ease of squeezing out the paste and the softness and hardness of the paste.

[0112] The extrusion performance of the diaper rash cream at low temperature is shown in Table 7;

[0113] Table 7 Test results of low-temperature hardness performance

[0114]

[0115]

[0116] Test Item 5: High Temperature Performance Test

[0117] Fill the diaper cream sample into the same packaging material, then place it in an oven at 60±1℃ for 24 hours, then take out the sample and observe the hardness of the diaper cream and whether it is stratified when it is just taken out.

[0118] The high temperature performance of diaper cream is shown in Table 8;

[0119] Table 8 High temperature performance test results

[0120]

[0121] Test Item 6: Soothing and redness fading test

[0122] Test method: First, use 2% SDS to artificially model, cut 2×2 small frames, add SDS20ul into each small chamber, and stick the spot tester on the back. The next day, remove the spot tester, and the subjects sit quietly at the required temperature for 30 minutes. During this period, they are not allowed to walk or eat. The test site is exposed and relaxed. The test area is marked according to the size of the spot tester. The sample area and the control area are randomly assigned according to the blind table. After 30 minutes, the SDS modeling situation is judged by naked eyes. If there are more than 2 obvious erythema in each area, the red pigment content at T0 is directly collected. The collection method is to mark the two reddest small frames visible to the naked eye in each area as the data collection area. After completing the data collection, the staff will follow up the blind table to apply samples to each area; if there is no obvious erythema in the modeling area of ​​the volunteer's arm, the skin barrier is damaged by tearing with low-allergenic tape and DMSO stimulation (4cm×4cm, smearing DMSO 30ul, reacting for more than 30 minutes, and then rinsing with water).

[0123] After the sample application is completed (2h, 4h): the same laboratory technician will perform red pigment measurement on the test area of ​​the subject and record the data.

[0124] The experimental results can be seen in Table 9;

[0125] Table 9 Soothing and redness fading test results

[0126]

[0127]

[0128] The data from Tables 4 to 9 above are summarized and analyzed, and the summary results can be seen in Table 10;

[0129] Table 10 Test results

[0130]

[0131] Result analysis:

[0132] 1. From the test results of soothing and reducing redness in 4 hours, Examples 2 to 4 have the best effects, and there are two factors: on the one hand, it is the dosage of the active ingredient, and on the other hand, it is the selection of the active ingredient. From the results of multiple cases, the dosage generally needs to reach more than 0.2%, and it is better to have at least one of stearyl glycyrrhetinate, bisabolol, and centella asiatica leaf extract;

[0133] 2. From the test results of the contact angle, Examples 2, 6 - 8 are relatively good, and Example 5 is the best; further combining the test results of Example 6 and Comparative Example 1, we can be relatively certain that lanolin helps to improve the immediate contact angle of the diaper rash cream.

[0134] From the test results of Comparative Example 2, Comparative Example 3, Comparative Example 4 and Example 6, trimethylolpropane tristearate, microcrystalline wax, and white beeswax are also very important for presenting a good contact angle.

[0135] From the test results of Comparative Example 5 and Example 6, it is necessary to keep the dosage of petrolatum more than that of light polar synthetic grease;

[0136] 3. From the test results of the urine barrier effect of the diaper rash cream, all comparative examples show worse results than Example 6, indicating that the ratio of lanolin, trimethylolpropane tristearate, microcrystalline wax, white beeswax and the main components all have an impact on the urine barrier performance; all cases in the examples have better performance, with Example 5 being an exception, indicating that as the addition amount of lanolin increases, the long-term urine barrier effect will decrease.

[0137] The possible synergistic cooperation mechanism among the above-mentioned components in terms of urine barrier performance is as follows: Lanolin raw material itself has a certain viscosity. It is speculated that when it comes into contact with urine, it can immediately fix the liquid droplets and slow down the diffusion rate of the liquid droplets. However, lanolin itself has relatively good water absorption. Over time, it will absorb urine, affecting the urine barrier effect. As the addition amount increases, the water absorption amount will also increase, which will instead affect the long-term urine barrier effect of the diaper rash cream. Utilizing the raw material characteristics of lanolin itself can assist in improving the urine barrier performance; Trihydroxystearin can form a crystalline molecular network structure with petrolatum and ethylhexyl stearate, which helps to stabilize the compatibility of each component and ensure the uniformity of the film formation of the diaper rash cream. Under high-temperature shear, the molecules straighten and stretch into an expanded state, with a large swelling volume, which can well suspend the light synthetic grease and lanolin with a relatively low melting point, ensuring the lasting performance of the film. Considering the high-humidity and high-stuffiness scenario when infants use diapers for a long time and the need to improve the urine barrier performance under high-temperature conditions, it is necessary to add trihydroxystearin. In addition, microcrystalline wax and white beeswax can form a stable and uniform paste with light polar synthetic grease, petrolatum, and other active ingredients, having good adhesiveness and ductility, which is helpful for the uniformity and persistence of the film formation of the diaper rash cream and can synergistically enhance the urine barrier performance.

[0138] 4. Judging from the temperature-dependent hardness changes of the diaper rash cream, that is, the high and low temperature performance data, obvious differences are shown in each example. Among them, Examples 2, 6-8 are all excellent; the reason for the poor high and low temperature performance of Example 1 is that as the addition amount of trihydroxystearin increases, the stretching space of its molecular network structure is limited, the network structure is dense, reducing the flexion and extension performance of the diaper rash cream paste, and the paste will be generally harder. In addition, the increase in the addition amount of microcrystalline wax and white beeswax will increase the melting point of the paste, making the paste harder. The increase in the addition amount of the oil-absorbing raw material will absorb more liquid grease, making the paste thick and hard and difficult to spread. The reason for the general low temperature performance of Examples 4 to 5 is that in Examples 4 and 5, as the addition amount of white beeswax and microcrystalline wax increases, the wax texture is relatively strong when the paste is used at low temperature, and the paste as a whole appears slightly harder. The reason for the general high temperature performance of Examples 3 to 4 is that in Example 3, the addition amount of white beeswax decreases, which will lower the melting point of the paste, making it slightly fluid at high temperature. In Example 4, due to the increase in the addition amount of liquid grease, the melting point of the paste will be lowered, making it slightly fluid at high temperature. Therefore, the high temperature performance is general.

[0139] In addition, the high temperature performance data of Comparative Examples 1-5 all show that they are relatively poor, indicating the importance of components such as lanolin, trihydroxystearin, microcrystalline wax, and white beeswax for the temperature-dependent hardness of the diaper rash cream paste, and none of them can be missing;

[0140] Considering comprehensively from various dimensions such as contact angle, overall sensory score, long-term urine barrier effect, high and low temperature performance, and soothing and anti-reddening effect, Example 2 has the best effect.

[0141] It is obvious to those skilled in the art that the present invention is not limited to the details of the above-described exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be embraced within the present invention. Any reference signs in the claims should not be construed as limiting the claims concerned.

Claims

1. A diaper cream, characterized in that: The composition includes the following weight percentages: Petrolatum: 44-57.5%; Light polar synthetic grease: 35-45%; Lanolin: 3-8%; Trihydroxystearin: 2-5%; Microcrystalline wax: 1-5%; Oil absorbing powder: 1-3%; White beeswax: 0.5-2%.

2. The diaper cream according to claim 1, characterized in that The composition includes the following weight percentages: Petrolatum: 44.7-54%; Light polar synthetic grease: 35-45%; Lanolin: 3-8%; Trihydroxystearin: 2-3%; Microcrystalline wax: 1-1.5%; Oil absorbing powder: 1-1.5%; White beeswax: 0.5-1%.

3. The diaper cream according to claim 1 or 2, characterized in that: Also included is 0.1 to 1% macadamia nut oil.

4. The diaper cream according to claim 1 or 2, characterized in that: The light polar synthetic oil is ethylhexyl stearate and / or caprylic / capric triglyceride.

5. The diaper cream according to claim 1 or 2, characterized in that: The oil-absorbing powder is starch octenyl succinate aluminum and / or boron nitride.

6. The diaper cream according to claim 1 or 2, characterized in that: It also includes redness-removing and soothing ingredients; the redness-removing and soothing ingredients are one or more of stearyl glycyrrhetinate, bisabolol, and Centella asiatica leaf extract.

7. The diaper cream according to claim 1 or 2, characterized in that: The dosage of the redness-removing and soothing component is 0.1-1.5%.

8. The diaper cream according to claim 1 or 2, characterized in that: The invention also comprises an active ingredient for inhibiting urease activity; the active ingredient is pomegranate peel extract and / or quercetin; and the dosage of the active ingredient is 0.001-0.01%.

9. A method for preparing the diaper cream according to any one of claims 1 to 8, characterized in that: The steps include: Step 1: Mix petrolatum, light polar synthetic oil, lanolin, trihydroxystearin, microcrystalline wax, and white beeswax, heat until melted, and homogenize; Step 2: Cool down to 55-70°C and stir to homogenize; Step 3: Add oil-absorbing powder to step 2, stir until homogeneous, then cool and discharge.

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