Chewing gum containing digestive tract defoaming agent and preparation method thereof

Abstract

The invention relates to a chewing gum containing a digestive tract defoaming agent and a preparation method thereof in the technical field of endoscopy, and is characterized in that the chewing gum comprises the following components in percentage by weight: 40 to 60 percent of gum base, 0.5 to 1.0 percent of dimeticone, 0 to 30 percent of sugar or sweetening agent, 0.1 to 0.5 percent of spice, 0.15 to 0.45 percent of softening agent, 0.1 to 0.5 percent of lubricating agent and 8 to 15 percent of water. The chewing gum disclosed by the invention is convenient to carry and use, and is particularly suitable for preparation before endoscopy; in the form of chewing gum, the chewing gum can be used when waiting for examination, so that intestinal movement is improved, and intestinal bubbles are improved; components which do not increase the gas production rate are adopted, and the problem of bubble aggravation is avoided; the taste is mainly fruity, such as mint, so that the acceptability of patients is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of endoscopy, and particularly relates to a digestive tract defoaming agent-containing chewing gum and a preparation method thereof. Background Art

[0002] In endoscopy, the presence of digestive tract bubbles will seriously affect the clarity and accuracy of the examination. The current defoaming agents on the market mainly include dimethicone and simethicone, and the dosage forms include chewable tablets, powders, emulsions, powders, aerosols, etc., but there is no chewing gum dosage form. The existing dosage forms have limitations in taking and effects, such as inconvenient to carry, inconvenient to take, unstable effects, etc. Summary of the Invention

[0003] In order to solve the above technical problems, a digestive tract defoaming agent-containing chewing gum and a preparation method thereof are proposed in the present invention. The technical solution of the present invention is realized as follows:

[0004] In the first aspect of the present invention, a digestive tract defoaming agent-containing chewing gum is disclosed. The chewing gum comprises the following component ratios: gum base 40wt%-60wt%, dimethicone 0.5wt%-1.0wt%, sugar or sweetener 0wt%-30wt%, flavor 0.1wt%-0.5wt%, softening agent 0.15wt%-0.45wt%, lubricant 0.1wt%-0.5wt%, and water 8wt%-15wt%.

[0005] The chewing gum of the present invention is convenient to carry and use, and is particularly suitable for the preparation before endoscopy; in the form of chewing gum, it can be used when waiting for the examination, improve intestinal motility, and improve intestinal bubbles; ingredients that do not increase the gas production are adopted to avoid aggravating the bubble problem; the flavor is mainly fruit flavor, such as mint, etc., to improve the acceptance of patients.

[0006] In the second aspect of the present invention, a preparation method of a digestive tract defoaming agent-containing chewing gum is disclosed. The method is used to prepare the digestive tract defoaming agent-containing chewing gum disclosed in the first aspect of the present invention, and the method comprises the following steps:

[0007] S1. Weigh raw materials: gum base 40wt%-60wt%, dimethicone 0.5wt%-1.0wt%, sugar or sweetener 0wt%-30wt%, flavor 0.1wt%-0.5wt%, softening agent 0.15wt%-0.45wt%, lubricant 0.1wt%-0.5wt%, and water 8wt%-15wt%;

[0008] S2. Prepare sugar water: Mix sugar or sweetener with water and heat to 70°C - 90°C, and stir for 20 - 60 minutes until completely dissolved;

[0009] S3. Gum base pretreatment: Heat the gum base alone to 70°C - 90°C to soften it;

[0010] S4. Mix raw materials: Mix the softened gum base, dimethicone, flavor, softener, lubricant with the sugar water in S2, and mix evenly;

[0011] If it is necessary to adjust the humidity, add an appropriate amount of water according to the requirement;

[0012] S5. Crushing and sieving: Crush the mixed material to a particle size < 150μm to ensure uniform texture;

[0013] S6. Processing and forming: Form by extrusion, pressing or cutting at 70°C - 90°C;

[0014] S7. Cooling and packaging: Package after cooling to room temperature.

[0015] Preferably, in S2, the mixing time is 20 min - 60 min.

[0016] Preferably, in S3, the particle size of the sieved material is less than 150μm.

[0017] Preferably, in S4, the stirring time is 20 min - 60 min.

[0018] Preferably, in S4, the heating temperature is 70°C - 90°C.

[0019] Preferably, in S5, the processing methods include extrusion, pressing or cutting.

[0020] Preferably, in S5, the processing temperature is 70°C - 90°C.

[0021] The advantages of the present invention are as follows:

[0022] 1. Convenience: The chewing gum form is convenient for patients to carry and use, and is especially suitable for use before endoscopic examination. During chewing, the defoaming agent is continuously released from the chewing gum. Compared with the instant release of chewable tablets, it can act on the digestive tract more continuously, thus providing a more stable defoaming effect during the whole endoscopic examination process. The comparative analysis data of the bubble volume before and after endoscopic examination show that the chewing gum starts to take effect within 10 minutes after starting to chew and can reach the best effect within 30 minutes, while the effects of dosage forms such as chewable tablets may start to weaken after 15 - 20 minutes.

[0023] 2. Efficacy: Dimethicone can effectively reduce the bubbles in the digestive tract, improving the clarity and accuracy of endoscopic examinations. This study collected endoscopic images of patients using the chewing gum of the present invention and a conventional defoaming agent (dimethicone powder). The results showed that in the endoscopic images of patients using the chewing gum of the present invention, the bubbles were significantly reduced and the clarity was remarkably improved. In addition, we also provided a comparison of a set of examination report results, showing that the examination results of patients using the chewing gum of the present invention were more accurate and the misdiagnosis rate was reduced. These data and images will be submitted as attachments with this application.

[0024] 3. Comfort: The fruit-flavored chewing gum improves the acceptance of patients, making the defoaming process more comfortable.

[0025] 4. Economy: The production cost of the chewing gum is relatively low and it is easy to produce on a large scale. Through market research and cost analysis, the production cost of the chewing gum of the present invention is relatively low. Compared with dosage forms such as chewable tablets, powders, emulsions, powders, and aerosols, the production process of the chewing gum is simpler and the raw material cost is also more economical. Specifically, the unit cost of the chewing gum of the present invention is about 30% lower than that of chewable tablets and about 50% lower than that of aerosols. This cost advantage makes the product of the present invention more competitive in the market. Market research shows that patients and medical professionals have a strong demand for new, convenient, and economical defoaming agents, and the chewing gum of the present invention is expected to meet this market demand. Detailed implementation manners

[0026] Next, the technical solutions of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0027] Unless otherwise defined, all technical and scientific terms used in the present invention have the same meaning as commonly understood by those skilled in the technical field to which the present invention belongs; the terms used in the detailed implementation manners are only for the purpose of describing specific embodiments and are not intended to limit the present invention; the terms "including" and "having" and any variations thereof in the description and claims of the present invention are intended to cover non-exclusive inclusion.

[0028] In the description of the specific implementation manners of the present invention, technical terms such as "first" and "second" are only used to distinguish different objects and cannot be understood as indicating or implying relative importance or implicitly indicating the quantity, specific order, or primary-secondary relationship of the indicated technical features. In the description of the embodiments of the present invention, "a plurality of" means more than two unless otherwise specifically defined.

[0029] References to "embodiments" in this invention mean that the specific features, structures, or characteristics described in connection with the embodiments can be included in at least one embodiment of the invention. The phrase appears in various places in the specification and does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described in this invention can be combined with other embodiments.

[0030] In the description of the embodiments of the present invention, the term "and / or" is merely a description of the association relationship of associated objects, indicating that there can be three relationships. For example, A and / or B can represent: A exists alone, A and B exist simultaneously, and B exists alone. In addition, the character " / " in the present invention generally represents an "or" relationship between the associated objects before and after.

[0031] Existing digestive tract defoaming agents have limitations in taking and effects, such as inconvenient to carry, inconvenient to take, unstable effects, etc. To solve these problems, the present invention discloses a technical solution, which is convenient to carry and use, and is particularly suitable for the preparation before endoscopic examination. This technical solution is in the form of chewing gum, which can be used while waiting for the examination, improve intestinal motility, and improve intestinal bubbles. This technical solution uses ingredients that do not increase the gas production volume to avoid aggravating the bubble problem. The taste of the chewing gum is mainly fruit flavor, such as mint, etc., to improve the acceptance of patients.

[0032] The first aspect of the present invention discloses a chewing gum containing a digestive tract defoaming agent, and the chewing gum comprises the following component ratios: gum base 40wt%-60wt%, dimethicone 0.5wt%-1.0wt%, sugar or sweetener 0wt%-30wt%, flavor 0.1wt%-0.5wt%, softening agent 0.15wt%-0.45wt%, lubricant 0.1wt%-0.5wt%, water 8wt%-15wt%.

[0033] In specific applications, the proportion of the gum base in the chewing gum can be selected as 40wt%, 45wt%, 50wt%, 55wt%, 60wt%, etc.; the proportion of dimethicone in the chewing gum can be selected as 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, etc.; the proportion of sugar or sweetener in the chewing gum can be selected as 1wt%, 3wt%, 5wt%, 8wt%, 10wt%, 15wt%, 20wt%, 25wt%, 30wt%, etc.; the proportion of flavor in the chewing gum can be selected as 0.1wt%, 0.2wt%, 0.3wt%, 0.4wt%, 0.5wt%, etc.; the proportion of softener in the chewing gum can be selected as 0.15wt%, 0.25wt%, 0.35wt%, 0.45wt%, etc.; the proportion of lubricant in the chewing gum can be selected as 0.1wt%, 0.2wt%, 0.3wt%, 0.4wt%, 0.5wt%, etc.; the proportion of water in the chewing gum can be selected as 8wt%, 10wt%, 12wt%, 15wt%, etc.; the values listed above are only examples and not limitations. Without exceeding the understanding of those skilled in the art, those skilled in the art can freely implement it.

[0034] The second aspect of the present invention discloses a preparation method of a digestive tract anti-foaming agent-containing chewing gum, which is used to prepare the digestive tract anti-foaming agent-containing chewing gum disclosed in the first aspect of the present invention. The method includes the following steps:

[0035] S1. Weigh raw materials: gum base 40wt%-60wt%, dimethicone 0.5wt%-1.0wt%, sugar or sweetener 0wt%-30wt%, flavor 0.1wt%-0.5wt%, softener 0.15wt%-0.45wt%, lubricant 0.1wt%-0.5wt%, water 8wt%-15wt%;

[0036] S2. Preparation of sugar water: Mix sugar or sweetener with water and heat to 70°C - 90°C, stir for 20 - 60 minutes until completely dissolved;

[0037] S3. Pretreatment of gum base: Heat the gum base alone to 70°C - 90°C to soften it;

[0038] S4. Mix raw materials: Mix the softened gum base, dimethicone, flavor, softener, lubricant with the sugar water in S2, and add the remaining water (if the humidity needs to be adjusted), and mix evenly;

[0039] S5. Crushing and sieving: Crush the mixed material to a particle size < 150μm to ensure uniform texture;

[0040] S6. Processing and forming: Extrude, press or cut into shape at 70°C - 90°C;

[0041] S7. Cooling and packaging: Package after cooling to room temperature.

[0042] In some embodiments, in S2, the mixing time is 20 min - 60 min.

[0043] In specific applications, the stirring time in S2 can be selected as 20 min, 30 min, 40 min, 50 min, 60 min, etc.; the values listed above are only examples and not limitations. Without exceeding the understanding of those skilled in the art, those skilled in the art can implement freely.

[0044] In some embodiments, in S3, the particle size of the sieved material is less than 150 μm.

[0045] In some embodiments, in S4, the stirring time is 20 min - 60 min.

[0046] In specific applications, the stirring time in S4 can be selected as 20 min, 30 min, 40 min, 50 min, 60 min, etc.; the values listed above are only examples and not limitations. Without exceeding the understanding of those skilled in the art, those skilled in the art can implement freely.

[0047] In some embodiments, in S4, the heating temperature is 70°C - 90°C.

[0048] In specific applications, the heating temperature in S4 can be selected as 70°C, 75°C, 80°C, 85°C, 90°C, etc.; the values listed above are only examples and not limitations. Without exceeding the understanding of those skilled in the art, those skilled in the art can implement freely.

[0049] In some embodiments, in S5, the processing methods include extrusion, pressing or cutting.

[0050] In some embodiments, in S5, the processing temperature is 70°C - 90°C.

[0051] In specific applications, the heating temperature in S5 can be selected as 70°C, 75°C, 80°C, 85°C, 90°C, etc.; the values listed above are only examples and not limitations. Without exceeding the understanding of those skilled in the art, those skilled in the art can implement freely.

[0052] The following will describe the embodiments of the present invention more specifically through examples. It should be noted that the embodiments of the present invention are not limited to these examples only.

[0053] Example 1: Preparation method of digestive antifoaming chewing gum

[0054] (1) Raw material preparation: Select the following raw materials, 1000 g of gum base, 5 g of dimethicone, 200 g of xylitol, 3 g of mint flavor, 30 g of softener, 20 g of lubricant, and 150 g of water;

[0055] (2) Syrup preparation: Mix xylitol and water and heat to 70°C - 90°C, stir for 30 minutes until completely dissolved;

[0056] (3) Gum base pretreatment: Heat the gum base alone to 70°C - 90°C to soften it;

[0057] (4) Mixing raw materials: Mix the softened gum base, dimethicone, mint flavor, softener, lubricant with the syrup, and mix evenly in a mixer; If it is necessary to adjust the humidity, add water as needed.

[0058] If it is necessary to adjust the humidity, add water as needed.

[0059] (5) Crushing and sieving: Crush the mixed material to a particle size < 150 μm to ensure the uniformity and delicate texture of the chewing gum;

[0060] (6) Processing and forming: Extrude, press or cut at 70°C - 90°C; Chewing gum can be made by extrusion, pressing or cutting, etc.

[0061] (7) Cooling and packaging: Cool the formed chewing gum to room temperature to ensure its hardness and stability. Finally, package the chewing gum to ensure hygiene and portability.

[0062] Example 2: Preparation method of digestive tract defoaming chewing gum

[0063] (1) Raw material preparation: Select the following raw materials, 1200 g of gum base, 7 g of dimethicone, 150 g of sucrose, 4 g of lemon flavor, 35 g of softener, 25 g of lubricant, and 120 g of water;

[0064] (2) Syrup preparation: Mix sucrose and water and heat to 70°C - 90°C, stir for 25 minutes until completely dissolved;

[0065] (3) Gum base pretreatment: Heat the gum base alone to 70°C - 90°C to soften it;

[0066] (4) Mixing raw materials: Mix the softened gum base, dimethicone, lemon flavor, softener, lubricant with the syrup, and mix evenly in a mixer; If it is necessary to adjust the humidity, add water as needed.

[0067] (5) Crushing and sieving: Crush the mixed material to a particle size < 150 μm to ensure the uniformity and delicate texture of the chewing gum;

[0068] (6) Processing and shaping: Shaping is carried out by extrusion, pressing or cutting at 70°C - 90°C; Chewing gum can be made by methods such as extrusion, pressing or cutting;

[0069] (7) Cooling and packaging: Cool the shaped chewing gum to room temperature to ensure its hardness and stability. Finally, package the chewing gum to ensure hygiene and portability.

[0070] It should be noted that the above are only preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims

1. A chewing gum containing a digestive tract defoaming agent, characterized in that: The chewing gum comprises the following ingredients in proportion: 40wt%-60wt% of gum base, 0.5wt%-1.0wt% of dimethicone, 0wt%-30wt% of sugar or sweetener, 0.1wt%-0.5wt% of flavor, 0.15wt%-0.45wt% of softener, 0.1wt%-0.5wt% of lubricant, and 8wt%-15wt% of water.

2. A method for preparing chewing gum containing a digestive tract defoaming agent, characterized in that: The steps include: S1. Weigh the raw materials: gum base 40wt%-60wt%, dimethicone 0.5wt%-1.0wt%, sugar or sweetener 0wt%-30wt%, flavor 0.1wt%-0.5wt%, softener 0.1wt%-0.45wt%, lubricant 0.1wt%-0.5wt%, water 8wt%-15wt%; S2. Preparation of sugar water: Mix sugar or sweetener with water and heat to 70°C-90°C, and stir for 20-60 minutes until completely dissolved; S3. Gum base pretreatment: Heat the gum base alone to 70°C-90°C to soften it; S4 mixed raw materials: the softened gum base, dimethicone, flavor, softener, lubricant and S2 syrup mixed, mix well; If the humidity needs to be adjusted, add appropriate amount of water according to the needs; S5. Crushing and sieving: crush the mixed material to a particle size of less than 150 μm to ensure uniform texture; S6. Processing: forming by extrusion, pressing or cutting at 70℃-90℃; S7. Cooling packaging: Packaging after cooling to room temperature.

3. The method according to claim 2, characterized in that In S2, the mixing time is 20 min-60 min.

4. The method according to claim 2, characterized in that: In S3, the particle size of the material after sieving is less than 150 μm.

5. The method according to claim 2, characterized in that: In S4, the stirring time is 20 min-60 min.

6. The method according to claim 2, characterized in that In the S4, the heating temperature is 70°C-90°C.

7. The method according to claim 2, characterized in that In S5, the processing method includes extrusion, pressing or cutting.

8. The method according to claim 7, characterized in that In the step S5, the processing temperature is 70°C-90°C.