Traditional Chinese medicine compound composition and ointment preparation for promoting deep second-degree burn wound healing and preparation method and application of traditional Chinese medicine compound composition and ointment preparation

Abstract

The invention relates to the technical field of traditional Chinese medicine wound repair, in particular to a traditional Chinese medicine compound composition for promoting deep II-degree burn wound healing, an ointment preparation and a preparation method and application thereof. According to the traditional Chinese medicine compound composition provided by the invention, the rehmannia, the prepared rehmannia root, the liquorice, the angelica sinensis, the coptis chinensis, the lithospermum, the earthworm, the mentholum and the egg yolk are compounded according to a specific dosage ratio, and the obtained product can well promote wound healing of burns and scalds, and achieves a better effect compared with clinically common medicines (such as meibao moist burn cream, purple flower burn cream and the like) for promoting healing of burns and scalds.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine wound repair, and particularly relates to a traditional Chinese medicine compound composition, an ointment preparation, a preparation method and an application thereof for promoting the healing of deep second-degree burn wounds. Background Art

[0002] Burns and scalds are injuries caused by high-temperature liquids (boiling water, hot oil), high-temperature solids (heated metals, etc.) or high-temperature steam, etc., and are common accidental injuries in life and production. After burns, due to the loss of the skin barrier function, infections are extremely likely to occur. If not properly treated, it will not only leave scars and disabilities, but may also endanger life.

[0003] The existing burn and scald treatment dressings are mainly silver ion dressings. However, silver ions are heavy metal ions. In case of severe burns, there is a risk of entering the blood through the wound surface and causing damage to tissues and organs through the circulatory system, and their prices are expensive. Research shows that traditional Chinese medicine has good antibacterial effects, and the antibacterial effects of some traditional Chinese medicine prescriptions are even better than antibiotics; in addition, traditional Chinese medicine has great potential in inhibiting tissue cell damage, inflammatory mediators and vascular exudation at the burn and scald sites. Therefore, the application of traditional Chinese medicine or traditional Chinese medicine compounds on burn and scald wounds is worthy of expectation.

[0004] In view of this, the present invention is specifically proposed. Summary of the Invention

[0005] To solve the above technical problems, the present invention selects natural active ingredients as raw materials for the product, and provides a traditional Chinese medicine compound composition for repairing deep second-degree burn wound surfaces, a preparation method and an application thereof.

[0006] Specifically, the technical solution of the present invention is as follows: In the first aspect, the present invention provides a traditional Chinese medicine compound composition for promoting the healing of deep second-degree burn wounds, and the raw material formula thereof includes the following components in parts by mass: 6-8 parts of Rehmannia glutinosa, 3-4 parts of prepared Rehmannia root, 2-3 parts of liquorice, 5-6 parts of Angelica sinensis, 6-7 parts of Coptis chinensis, 4-12 parts of Arnebia euchroma, 6-8 parts of Pheretima aspergillum, 0.5-1.2 parts of menthol ice, and 6-10 parts of egg yolk.

[0007] The present invention selects natural active ingredients as raw materials for the product, and adopts the compatibility method of monarch, minister, assistant and envoy. Earthworm is used as the monarch drug, egg yolk oil, lithospermum root, rehmannia root and prepared rehmannia root are used as the minister drugs, coptis root, angelica root and menthol ice are used as the assistant drugs, and licorice root is used as the envoy drug. Among them, earthworm is used to promote the proliferation of fibroblasts in granulation tissue, accelerate the formation of granulation tissue, and promote epidermal growth; it plays the role of promoting the secretion of actin and promoting wound contraction in the formula. Egg yolk oil has a lubricating texture and good moisturizing effect. It contains rich vitamins A, D and lecithin, etc., which can promote the regeneration and metabolism of the skin, and has the effects of nourishing the skin, promoting granulation and preventing infection. Lithospermum root, rehmannia root and prepared rehmannia root play the roles of clearing heat and cooling blood, removing stasis and detoxifying, relieving pain and promoting granulation. Coptis root has antibacterial and anti-inflammatory effects; angelica root can dilate blood vessels and improve blood circulation; licorice root has the effects of moderating the properties of drugs and reducing the side effects of drugs, and at the same time has antibacterial, anti-inflammatory and anti-allergic effects; menthol ice has the effects of dispelling wind and heat, and relieving pain. The present invention combines the above-mentioned components, and the obtained traditional Chinese medicine compound composition can well promote the healing of burn and scald wounds, achieving better effects than the commonly used clinical drugs for promoting the healing of burn and scald (such as MEBO).

[0008] Preferably, the raw material formula includes the following components in parts by mass: 6 - 7.2 parts of rehmannia root, 3 - 3.6 parts of prepared rehmannia root, 2 - 2.4 parts of licorice root, 5 - 5.6 parts of angelica root, 6 - 6.4 parts of coptis root, 4 - 9.6 parts of lithospermum root, 6 - 6.7 parts of earthworm, 0.5 - 0.8 parts of menthol ice, and 6 - 8 parts of egg yolk.

[0009] Another preferably, the raw material formula includes the following components in parts by mass: 7.2 - 8 parts of rehmannia root, 3.6 - 4 parts of prepared rehmannia root, 2.4 - 3 parts of licorice root, 5.6 - 6 parts of angelica root, 6.4 - 7 parts of coptis root, 9.6 - 12 parts of lithospermum root, 6.7 - 8 parts of earthworm, 0.8 - 1.2 parts of menthol ice, and 8 - 10 parts of egg yolk.

[0010] In a second aspect, the present invention provides a preparation method of the traditional Chinese medicine compound composition, including the step of mixing each raw material according to parts by weight; before mixing each raw material according to parts by weight, it further includes at least one of the following processing steps: (1) Placing rehmannia root, prepared rehmannia root, licorice root, angelica root, coptis root and lithospermum root in sesame oil at 160 ± 10 °C for 20 - 40 min, adding earthworm, and turning to slow fire to boil for 40 - 80 min; (2) Placing the egg yolk in an iron pan and frying it over low heat to collect the egg yolk oil.

[0011] Preferably, before processing, rehmannia root, prepared rehmannia root, licorice root, angelica root and lithospermum root are sliced first. The slice thickness of rehmannia root or prepared rehmannia root is 3 - 5 mm, the slice thickness of licorice root is 2 - 4 mm, and the slice thickness of angelica root and lithospermum root is 1 - 2 mm.

[0012] Preferably, before processing, the menthol ice is pulverized, and the pulverization particle size is 60±10 mesh.

[0013] Preferably, the preparation method of the present invention includes: placing Rehmannia glutinosa, prepared Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica sinensis, Coptis chinensis, and Lithospermum erythrorhizon in sesame oil at 160±10°C for 20 - 40 min (more preferably 30 min, frying until the oil turns purplish red, removing the medicinal residues), adding Pheretima aspergillum, turning to slow fire and boiling for 40 - 80 min (more preferably 60 min, frying until the inside is yellow and the outside is charred, removing the medicinal residues); taking the egg yolk of a cooked egg and frying it in a iron pan over low heat to collect the egg yolk oil; mixing the extracted liquid of sesame oil after boiling, the egg yolk oil, and the menthol ice. The above processing technology of the present invention is beneficial to the release of active ingredients in the raw materials and improves the repair effect on burn and scald wounds.

[0014] More preferably, after mixing the extracted liquid of sesame oil after boiling, the egg yolk oil, and the menthol ice, beeswax is added under the temperature condition of 60 - 70°C, and then cooled and formed. Among them, the addition amount of beeswax is 10% - 50%. Beeswax has the functions of moisturizing and preventing drug layering. Adding beeswax in the present invention helps to improve the product properties.

[0015] Preferably, the volume of the sesame oil after boiling is concentrated to 60% - 70% (more preferably 66.67%) of the original volume.

[0016] Preferably, the concentration of menthol ice in the traditional Chinese medicine compound composition is 0.6% - 1.0% (more preferably 0.8%).

[0017] In the third aspect, the present invention provides the application of the traditional Chinese medicine compound composition or the preparation method in the preparation of a product for promoting the healing of deep second-degree burn wounds; the product can be an oily ointment external preparation, or a derivative product obtained by supplementing the oily ointment external preparation with a medically acceptable carrier.

[0018] Beneficial effects: The present invention provides a traditional Chinese medicine compound composition for repairing deep second-degree burn wound surfaces, its preparation method and application. The traditional Chinese medicine compound composition provided by the present invention uses Rehmannia glutinosa, prepared Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica sinensis, Coptis chinensis, Lithospermum erythrorhizon, Pheretima aspergillum, menthol ice, and egg yolk as raw materials in specific dosage ratios. The obtained product can well promote the healing of burn and scald wounds (especially deep second-degree burn wounds), and at the same time has the functions of clearing heat and anti-inflammatory, achieving a better wound surface repair effect than clinically commonly used drugs for promoting burn and scald wound healing (such as MEBO or Zihua Burn Ointment from the Chinese Pharmacopoeia). Description of the drawings

[0019] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the following will describe the drawings required for use in the examples or the description of the prior art.

[0020] Figure 1 This is the flow chart for preparing the traditional Chinese medicine compound oil-based ointment of the present invention.

[0021] Figure 2 This is the diagram of the wound repair status of the burned skin of mice on the fourteenth day of the present invention.

[0022] Figure 3 This is the HE staining diagram of the burned skin of mice on the fourteenth day of the present invention. Detailed implementation manners

[0023] The present invention provides a formula for a traditional Chinese medicine compound oil-based ointment that can promote the healing of deep second-degree burn wounds and a preparation method thereof.

[0024] In one relatively specific and preferred implementation manner, the formula of a traditional Chinese medicine compound oil-based ointment that can promote the healing of deep second-degree burn wounds provided by the present invention includes the following raw materials: Rehmannia glutinosa, processed Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica sinensis, Coptis chinensis, Lithospermum erythrorhizon, Pheretima aspergillum, menthol ice, egg yolk, etc., and are proportioned according to the following weights and components: 7.2 grams of Rehmannia glutinosa, 3.6 grams of processed Rehmannia glutinosa, 2.4 grams of Glycyrrhiza uralensis, 5.6 grams of Angelica sinensis, 6.4 grams of Coptis chinensis, 9.6 grams of Lithospermum erythrorhizon, 6.7 grams of Pheretima aspergillum, 0.8 grams of menthol ice, 8.0 grams of egg yolk, 25 grams of beeswax.

[0025] In one relatively specific and preferred implementation manner, the preparation method of the formula of a traditional Chinese medicine compound gel preparation that can promote the healing of deep second-degree scald wounds provided by the present invention includes the following steps: Step 1, preliminary processing; Step 2, grinding and sterilization of medicinal materials; Step 3, boiling the traditional Chinese medicine stock solution with sesame oil; Step 4, refining egg yolk oil; Step 5, adding active ingredients and mixing evenly, synthesizing the oil-based ointment; Step 6, internal and external packaging.

[0026] Preferably, in the above Step 1, the cleaning work of various medicinal materials is done well. The staff in the dispensing room selects Rehmannia glutinosa, processed Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica sinensis, Coptis chinensis, Lithospermum erythrorhizon, Pheretima aspergillum, menthol ice, and egg yolk that meet the medicinal requirements according to the formula requirements, and the staff fully extracts the processed medicinal materials in the ultra-clean workbench.

[0027] Preferably, in the above Step 2, the staff cuts Rehmannia glutinosa, processed Rehmannia glutinosa, Glycyrrhiza uralensis, Lithospermum erythrorhizon, and Angelica sinensis into thin slices, crushes menthol ice into fine powder, and performs ultraviolet disinfection for 30 minutes.

[0028] Preferably, in the above Step 3, the staff pours a certain amount of pre-prepared Rehmannia glutinosa, processed Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica sinensis, Coptis chinensis, and Lithospermum erythrorhizon into a clean pot, boils with sesame oil over high heat for 30 minutes, adds Pheretima aspergillum and turns to slow fire for 60 minutes, filters and cools, and seals for later use.

[0029] Preferably, in the above step four, select a certain number of eggs, cook them, take the egg yolks, fry them in a cast-iron pot over low heat, and collect the egg yolk oil.

[0030] Preferably, in the above step five, mix the products obtained in the above steps three and four according to the proportion of drug ingredients, and add an appropriate amount of menthol ice and beeswax, and stir evenly.

[0031] More preferably, the staff performs inner and outer packaging on the oily ointment and stores it in a cool, ventilated and dry area.

[0032] More preferably, when screening the medicinal materials in step one, remove the soil and soil dust in the medicinal materials, and perform low-temperature and drying treatments on rehmannia glutinosa, prepared rehmannia root, licorice root, lithospermum erythrorhizon, angelica sinensis, coptis chinensis, and earthworm.

[0033] More preferably, when decocting the traditional Chinese medicine stock solution in step three, add 120 ml of sesame oil in total, and obtain 80 ml of traditional Chinese medicine stock solution in total when the decoction is completed.

[0034] More preferably, the concentration of menthol ice added in step five is 0.8%.

[0035] The oily ointment prepared by the above preferred scheme of the present invention has the characteristics of softness and moisture retention, can provide a moist environment for the wound surface and can fill irregular wound surfaces. By using sesame oil and egg yolk oil as the matrix, the traditional Chinese medicine compound ointment of the present invention is lubricating, non-irritating, with appropriate consistency, easy to apply on the skin, stable in nature, does not have compatibility changes with the main drug, does not interfere with the normal functions of the skin, and has good drug release performance. The oily ointment external preparation with a certain consistency prepared by uniformly mixing with the traditional Chinese medicine stock solution can mainly promote the healing of burn and scald wounds, and at the same time has the effects of clearing heat and anti-inflammatory, promoting the formation of new blood vessels in the wound area, and having good bactericidal efficacy on the local wound surface. It is convenient to use, has no irritation, damage, allergy to the skin, has a fast onset, and has significant curative effects. Through the efficacy observation and verification on the mouse model of deep second-degree burn wounds, this medicine has good antibacterial activity, can inhibit excessive inflammation, moisten the wound surface, promote collagen deposition in the wound area, and has the effect of promoting the healing of deep second-degree burn wounds.

[0036] To make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions in the present invention will be clearly and completely described below. Obviously, the described embodiments are some of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0037] The endpoints and any values in the ranges disclosed in this specification are not limited to the exact ranges or values. These ranges or values should be understood to include values close to these ranges or values. For numerical ranges, between the endpoint values of each range, between the endpoint values of each range and individual point values, and between individual point values, they can be combined with each other to obtain one or more new numerical ranges, and these numerical ranges should be regarded as specifically disclosed herein.

[0038] In the description of this specification, the description referring to terms such as "one embodiment", "some embodiments", "specific implementation manners", or "some specific implementation manners", etc. means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the embodiments of the present invention. In this specification, the schematic expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0039] In the embodiments provided in this specification, for those without specific technologies or conditions indicated, they are carried out according to the technologies or conditions described in the literature in this field or according to the product specifications. For reagents or instruments without the manufacturer indicated, they are all conventional products that can be obtained through regular channels.

[0040] In the present invention, the expression of "slow fire" can be selected according to the following standards: the unit heat is about 1440 kJ / h; the power is 400 W, and the temperature range is 60 - 100 °C; the expression of "small fire" can be selected according to the following standards: the unit heat is about 2880 kJ / h; the power is 800 W, and the temperature range is 120 - 180 °C.

[0041] Example 1 This example provides a traditional Chinese medicine compound oily ointment that can promote the healing of deep second-degree burn wounds. Its formula includes the following raw materials: Rehmannia glutinosa, Prepared Rehmannia Root, Licorice Root, Angelica sinensis, Coptis chinensis, Lithospermum erythrorhizon, Earthworm, Menthol Crystal, and egg yolk, and is proportioned according to the following weights and components: 7.2 grams of Rehmannia glutinosa, 3.6 grams of Prepared Rehmannia Root, 2.4 grams of Licorice Root, 5.6 grams of Angelica sinensis, 6.4 grams of Coptis chinensis, 9.6 grams of Lithospermum erythrorhizon, 6.7 grams of Earthworm, 0.8 grams of Menthol Crystal, 8.0 grams of egg yolk, and 25 grams of beeswax.

[0042] This example provides a preparation method of the above traditional Chinese medicine compound oily ointment. Refer to Figure 1 , and specifically includes the following steps: Step 1, preliminary processing: Do a good job in cleaning all kinds of medicinal materials. The staff in the dispensing room select Rehmannia glutinosa, prepared Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica sinensis, Coptis chinensis, Lithospermum erythrorhizon, Pheretima aspergillum, menthol ice, and egg yolk that meet the medicinal requirements according to the formula requirements. The staff extract the processed medicinal materials in full amount in the ultra-clean workbench. When screening the medicinal materials, remove the soil and soil dust in the medicinal materials, and conduct low-temperature and drying treatments on Rehmannia glutinosa, prepared Rehmannia glutinosa, Glycyrrhiza uralensis, Lithospermum erythrorhizon, Angelica sinensis, Coptis chinensis, and Pheretima aspergillum.

[0043] Step 2, grinding and sterilization of medicinal materials: The staff cut Rehmannia glutinosa, prepared Rehmannia glutinosa, Glycyrrhiza uralensis, Lithospermum erythrorhizon, and Angelica sinensis into thin slices, and crush menthol ice into fine powder, and conduct ultraviolet disinfection for 30 minutes.

[0044] Step 3, boiling Chinese medicine stock solution with sesame oil: Pour the prepared and certain amounts of Rehmannia glutinosa, prepared Rehmannia glutinosa, Glycyrrhiza uralensis, Angelica sinensis, Coptis chinensis, and Lithospermum erythrorhizon into a clean pot, add sesame oil and bring to a boil over high heat for 30 minutes, add Pheretima aspergillum and turn to low heat and boil for 60 minutes, filter and let cool, and seal for later use. A total of 120 milliliters of sesame oil is added when boiling the Chinese medicine stock solution, and a total of 80 milliliters of Chinese medicine stock solution is obtained when the boiling is completed.

[0045] Step 4, refining egg yolk oil: Select a certain number of eggs, cook them, take the egg yolks, and fry them over low heat in an iron pot to collect the egg yolk oil.

[0046] Step 5, adding active ingredients and mixing evenly, ointment synthesis: Mix the products obtained in Steps 3 and 4 according to the proportion of drug ingredients, and add appropriate amounts of menthol ice and beeswax, and stir evenly. The concentration of added menthol ice is 0.8%.

[0047] Step 6, internal and external packaging: The staff conduct internal and external packaging on the oily ointment and store it in a cool, ventilated and dry area.

[0048] Example 2 This example provides a traditional Chinese medicine compound oily ointment that can promote the healing of deep second-degree burn wounds. Compared with Example 1, the only difference is that the formula is proportioned according to the following weights and components: 6 grams of Rehmannia glutinosa, 3 grams of prepared Rehmannia glutinosa, 2 grams of Glycyrrhiza uralensis, 5 grams of Angelica sinensis, 6 grams of Coptis chinensis, 4 grams of Lithospermum erythrorhizon, 6 grams of Pheretima aspergillum, 0.5 grams of menthol ice, 6 grams of egg yolk, and 8 grams of beeswax.

[0049] Example 3 This example provides a traditional Chinese medicine compound oily ointment that can promote the healing of deep second-degree burn wounds. Compared with Example 1, the only difference is that the formula is proportioned according to the following weights and components: 8 grams of Rehmannia glutinosa, 4 grams of prepared Rehmannia glutinosa, 3 grams of Glycyrrhiza uralensis, 6 grams of Angelica sinensis, 7 grams of Coptis chinensis, 12 grams of Lithospermum erythrorhizon, 8 grams of Pheretima aspergillum, 1.2 grams of menthol ice, 10 grams of egg yolk, and 40 grams of beeswax.

[0050] Example 4 To further prove that the traditional Chinese medicine compound oily ointment of the present invention has good effects in the repair of deep second-degree burn wounds, the following experiments were conducted in this embodiment: SD mice aged 8-10 weeks with both male and female genders were selected. Deep second-degree burn wounds with a diameter of 8 mm were made on the back of each mouse. The mice were divided into a blank control group (without any other treatment), a positive control group I (using MEBO), a positive control group II (using Zihua burn ointment), a traditional Chinese medicine compound ointment group I (using the traditional Chinese medicine compound oily ointment of Example 1), a traditional Chinese medicine compound ointment group II (using the traditional Chinese medicine compound oily ointment of Example 2), and a traditional Chinese medicine compound ointment group III (using the traditional Chinese medicine compound oily ointment of Example 3) by the random number table method. The wound was dressed once a day. After dressing, the wound was covered with a sterile gauze and bandaged with an elastic bandage.

[0051] The results are shown in Figure 2 and Figure 3 .

[0052] As Figure 2 shown is the diagram of the wound repair state of the mouse skin on the fourteenth day. As Figure 3 shown is the HE staining diagram of the mouse skin on the fourteenth day. Compared with the blank control group, the positive control group I, and the positive control group II, it can be seen that the number of inflammatory cells in the tissue sections of HE staining in the three groups of traditional Chinese medicine compound ointments significantly decreased, the number of newly formed blood vessels significantly increased, and the gross wound surface significantly decreased. Among them, the effect of the traditional Chinese medicine compound ointment group I was the best.

[0053] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicinal compound composition for promoting the healing of deep second degree burn wounds, characterized in that: The raw material formula comprises the following components in parts by weight: 6-8 parts of rehmannia root, 3-4 parts of prepared rehmannia root, 2-3 parts of liquorice, 5-6 parts of angelica root, 6-7 parts of coptis root, 4-12 parts of lithospermum officinale, 6-8 parts of earthworm, 0.5-1.2 parts of mint ice and 6-10 parts of egg yolk.

2. The Chinese medicine compound composition according to claim 1, characterized in that: The raw material formula comprises the following components in parts by weight: 6-7.2 parts of rehmannia root, 3-3.6 parts of prepared rehmannia root, 2-2.4 parts of liquorice, 5-5.6 parts of angelica root, 6-6.4 parts of coptis root, 4-9.6 parts of lithospermum officinale, 6-6.7 parts of earthworm, 0.5-0.8 parts of mint ice and 6-8 parts of egg yolk.

3. The Chinese medicine compound composition according to claim 1, characterized in that: The raw material formula comprises the following components in parts by weight: 7.2-8 parts of rehmannia root, 3.6-4 parts of prepared rehmannia root, 2.4-3 parts of liquorice, 5.6-6 parts of angelica root, 6.4-7 parts of coptis root, 9.6-12 parts of lithospermum officinale, 6.7-8 parts of earthworm, 0.8-1.2 parts of mint ice and 8-10 parts of egg yolk.

4. The method for preparing the Chinese medicine compound composition according to any one of claims 1 to 3, comprising the step of mixing the raw materials in parts by weight, characterized in that: Before mixing the raw materials by weight, at least one of the following preparation steps is also included: (1) Place Rehmannia root, Rehmannia root, Licorice root, Angelica root, Coptis root and Lithospermum officinale in sesame oil at 160±10℃ for 20-40min, add earthworm and simmer for 40-80min on low heat; (2) Place the egg yolks in an iron pan and fry over low heat, collecting the egg yolk oil.

5. The preparation method according to claim 4, characterized in that: Rehmannia root, Rehmannia root prepared, Licorice, Chinese Angelica and Lithospermum officinale are sliced ​​before processing. The slice thickness of Rehmannia root or Rehmannia root prepared is 3-5 mm, the slice thickness of Licorice root is 2-4 mm, and the slice thickness of Chinese Angelica and Lithospermum officinale is 1-2 mm.

6. The preparation method according to claim 4, characterized in that: The mint ice is crushed before preparation, and the particle size is 60±10 mesh.

7. The preparation method according to claim 4, characterized in that: Place Rehmannia root, Rehmannia root prepared, Licorice root, Angelica root, Coptis root and Lithospermum officinale in sesame oil at 160±10℃ for 20-40min, add earthworms and simmer for 40-80min on low heat; take out the yolk of boiled eggs and fry them in an iron pan on low heat to collect the egg yolk oil; mix the sesame oil extract, egg yolk oil and mint ice.

8. The preparation method according to claim 7, characterized in that: After boiling, the volume of sesame oil is concentrated to 60%-70% of its original volume.

9. The preparation method according to claim 7, characterized in that: The concentration of mint ice in the traditional Chinese medicine compound composition is 0.6%-1.0%.

10. Use of the Chinese herbal compound composition according to any one of claims 1 to 3 or the preparation method according to any one of claims 4 to 9 in the preparation of a product for promoting the healing of deep second-degree burn wounds; the product can be an oily ointment for external use, or a derivative product obtained by adding a medically acceptable carrier to the oily ointment for external use.

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