Nutritional composition for relieving and / or improving depression as well as preparation method and application of nutritional composition

Abstract

The invention relates to a nutritional composition for relieving and / or improving depression and a preparation method and application thereof, and belongs to the technical field of health food. The nutritional composition comprises the following components in parts by mass: 18-36 parts of radix paeoniae alba, 20-40 parts of radix angelicae sinensis, 15-25 parts of radix morindae officinalis, 16-22 parts of fructus lycii, 10-30 parts of cortex eucommiae, 12-24 parts of radix salviae miltiorrhizae, 7-15 parts of rhizoma chuanxiong, 4-12 parts of semen pruni, 12-22 parts of oyster meat, 10-20 parts of rhizoma gastrodiae, 3-8 parts of radix polygalae and 3-6 parts of radix glycyrrhizae. The nutritional composition disclosed by the invention can play a role in relieving and / or improving depression, and has the advantages of good conditioning and health-care effects and high safety.

Description

Technical Field

[0001] The present invention relates to the technical field of health foods, and in particular to a nutritional composition for relieving and / or improving depression, its preparation method and application. Background Art

[0002] Depression is a common mental illness, mainly manifested as persistent low mood and mood disorders. Its pathogenesis is related to many factors such as abnormal neurotransmitter expression, secretion of inflammatory factors, disorder of the hypothalamic-pituitary-adrenal axis, change of intestinal flora environment, and abnormal mitochondrial structure and function.

[0003] According to traditional Chinese medicine theory, the core cause of depression lies in the liver and is closely related to the spleen, kidney and heart. The basic pathogenesis is qi stagnation and disorder of zang-fu functions, belonging to the categories of "depression syndrome", "hysterical psychosis", "lily disease", etc. According to the cause and pathogenesis of depression, depression can be divided into syndromes such as liver qi stagnation, qi stagnation transforming into fire, phlegm qi stagnation, loss of nourishment of the mind, and deficiency of both the heart and spleen.

[0004] At present, chemical drugs can relieve depressive symptoms to a certain extent in clinical practice, but there are often problems such as slow onset, poor treatment effect, long treatment course, obvious toxic and side effects, and high recurrence rate. Summary of the Invention

[0005] The purpose of the present invention is to provide a nutritional composition for relieving and / or improving depression, its preparation method and application, so as to solve the problems of poor effect, low safety and strong side effects in the existing preparations for relieving and / or improving depression.

[0006] In order to achieve the above-mentioned invention purpose, the present invention provides the following technical solutions:

[0007] The present invention provides a nutritional composition, which is characterized by comprising the following components in parts by mass: 18-36 parts of white peony root, 20-40 parts of Chinese angelica, 15-25 parts of morinda officinalis, 16-22 parts of wolfberry fruit, 10-30 parts of eucommia ulmoides, 12-24 parts of salvia miltiorrhiza, 7-15 parts of ligusticum wallichii, 4-12 parts of prunus davidiana, 12-22 parts of oyster meat, 10-20 parts of gastrodia elata, 3-8 parts of polygala tenuifolia, 3-6 parts of licorice root.

[0008] The present invention also provides a preparation method of the above-mentioned nutritional composition, comprising the following steps:

[0009] (1) Mix white peony root, Chinese angelica, morinda officinalis, wolfberry fruit, eucommia ulmoides, salvia miltiorrhiza, ligusticum wallichii, prunus davidiana, oyster meat, gastrodia elata, polygala tenuifolia and licorice root, and pulverize for 60-90 s to obtain a mixture;

[0010] (2) Mix the mixture with water and decoct for 20-60 min, filter and take the filtrate to obtain an extract;

[0011] (3) Concentrate and dry the leaching solution to obtain the nutritional composition.

[0012] Preferably, the comminution in step (1) is ultrafine comminution, and the particle size of the comminution is 20 - 50 μm.

[0013] Preferably, the mass - volume ratio of the mixture to water in step (2) is 10 - 15 g:15 - 22 mL;

[0014] The decocting temperature in step (2) is 80 - 100 °C.

[0015] Preferably, the concentration in step (3) is vacuum concentration, the concentration temperature is 20 - 35 °C, the vacuum degree of concentration is 0.02 - 0.08 bar, and the concentration time is 15 - 60 min.

[0016] Preferably, the drying in step (3) is spray drying, the drying temperature is 135 - 175 °C, and the drying time is 5 - 10 s.

[0017] The present invention also provides the application of the above - mentioned nutritional composition in the preparation of health foods for relieving and / or improving depression.

[0018] The present invention also provides the application of the nutritional composition prepared by the above - mentioned preparation method in the preparation of health foods for relieving and / or improving depression.

[0019] The present invention has the following technical effects and advantages:

[0020] The components contained in the nutritional composition of the present invention are all raw materials of both medicine and food, with high safety, no toxic and side effects on the body, and each component follows the compatibility principle of "sovereign, ministerial, adjuvant, and guiding herbs" in traditional Chinese medicine theory. Taking white peony root and angelica as the sovereign herbs, treating depression - related symptoms from the perspective of nourishing the liver and softening the liver, and nourishing the mind; taking morinda officinalis, wolfberry, eucommia ulmoides, and salvia miltiorrhiza as the ministerial herbs, assisting the sovereign herbs to fundamentally regulate the physical and mental state, stabilizing the body foundation and emotional changes. Among them, morinda officinalis and wolfberry are complementary in yin and yang to enhance the effect of the sovereign herbs in nourishing yin and calming the mind, eucommia ulmoides can assist morinda officinalis and wolfberry in tonifying the liver and kidney, and salvia miltiorrhiza assists angelica in enhancing the effect of nourishing blood and promoting blood circulation; taking ligusticum wallichii, prunus japonica, oyster meat, and gastrodia elata as the adjuvant herbs, which helps the sovereign and ministerial herbs to play the role of stabilizing and improving mood. Among them, ligusticum wallichii can strengthen the effect of salvia miltiorrhiza in promoting blood circulation and regulating qi to make qi and blood unobstructed, prunus japonica plays a role in regulating the overall medicinal property of the nutritional composition in guiding supplementation without stagnation, oyster meat can restrict the warm - dry property of other components to make the overall medicinal property of the nutritional composition more gentle and stable, and gastrodia elata can enhance the improvement effect of the nutritional composition on mood - related symptoms; taking polygala tenuifolia and licorice as the guiding herbs, which can relieve the medicinal property conflict between the components in the nutritional composition, guide each component to play a synergistic role, and enable the nutritional composition to better play the role of relieving and / or improving depression;

[0021] In the nutritional composition of the present invention, components such as wolfberry, eucommia bark, salvia miltiorrhiza, prunus humilis bge seeds, and oyster meat are rich in zinc element, which helps to maintain various neurotransmitters in the body at normal levels, reduce the damage and apoptosis of nerve cells, lower the oxidative stress level and chronic inflammatory response, improve the sensitivity of taste and smell of depression patients to increase appetite, and assist in improving the physical condition and emotional state of depression patients, thereby exerting the effect of relieving and / or improving depression. Detailed implementation manners

[0022] The present invention provides a nutritional composition, which is characterized by comprising the following components in parts by mass: 18 - 36 parts of white peony root, preferably 25 - 30 parts, and more preferably 27 parts; 20 - 40 parts of Chinese angelica, preferably 25 - 35 parts, and more preferably 32 parts; 15 - 25 parts of morinda officinalis, preferably 18 - 23 parts, and more preferably 21 parts; 16 - 22 parts of wolfberry, preferably 18 - 20 parts, and more preferably 19 parts; 10 - 30 parts of eucommia bark, preferably 12 - 25 parts, and more preferably 16 parts; 12 - 24 parts of salvia miltiorrhiza, preferably 19 - 22 parts, and more preferably 20 parts; 7 - 15 parts of chuanxiong rhizome, preferably 9 - 13 parts, and more preferably 11 parts; 4 - 12 parts of prunus humilis bge seeds, preferably 6 - 10 parts, and more preferably 8 parts; 12 - 22 parts of oyster meat, preferably 16 - 20 parts, and more preferably 18 parts; 10 - 20 parts of gastrodia elata, preferably 12 - 16 parts, and more preferably 14 parts; 3 - 8 parts of polygala tenuifolia, preferably 4 - 7 parts, and more preferably 6 parts; 3 - 6 parts of liquorice, preferably 5 parts.

[0023] White peony root is the dried root of the perennial herbaceous peony (Paeonia lactiflora) of the genus Paeonia in the family Paeoniaceae. It is slightly cold in nature, bitter and sour in taste, and belongs to the liver and spleen meridians, and has the effects of soothing the liver and relieving depression, regulating qi and strengthening the spleen.

[0024] Chinese angelica is the dried root of the perennial herbaceous Chinese angelica (Angelica sinensis) of the genus Angelica in the family Umbelliferae. It is warm in nature, sweet, pungent and bitter in taste, and belongs to the heart, liver and spleen meridians, and can nourish the mind and improve depressive symptoms such as low mood and listlessness.

[0025] Morinda officinalis is the dried root of the vine morinda officinalis of the genus Morinda in the family Rubiaceae. It is slightly warm in nature, sweet and pungent in taste, and belongs to the liver and kidney meridians, and has the effects of tonifying the kidney yang and strengthening the bones and muscles, etc., which helps to improve symptoms such as listlessness and weakness. The morinda officinalis oligosaccharides contained can increase the expression of neurotrophic factors, regulate synaptic plasticity, and regulate the neurotrophic signal transduction pathway, thereby improving depressive symptoms.

[0026] Wolfberry is the dried mature fruit of the Ningxia wolfberry (Lycium barbarum), a shrub of the Solanaceae family. It is mild in nature, sweet in taste, and enters the lung, liver, and kidney meridians. It has the functions of nourishing the liver and kidneys, and replenishing the essence and blood. Its zinc content is 10-15 mg / 100g.

[0027] Eucommia ulmoides is the dried bark of the deciduous tree Eucommia ulmoides of the Eucommia family. It is warm in nature, sweet and slightly spicy in taste, and enters the liver and kidney meridians. It has the effects of nourishing the liver and kidneys, strengthening the tendons and bones, and invigorating qi and blood. The total flavonoids of Eucommia ulmoides contained in it can especially improve the symptoms of depression combined with perimenopause. Its zinc content is 50-80 mg / 100g.

[0028] Salvia miltiorrhiza is the dried root of Salvia miltiorrhiza, a perennial herb of the Lamiaceae family. It is slightly warm in nature, bitter in taste, and enters the heart and liver meridians. It has the effects of clearing the heart and relieving restlessness, calming the nerves and promoting sleep. The salvianolic acid it contains can improve inflammatory response and glucocorticoid dysfunction, thereby exerting anti-depressant and anti-anxiety effects. Its zinc content is 5.5-10.2 mg / 100g.

[0029] Chuanxiong is the dried rhizome of the perennial herb Ligusticum sinense 'Chuanxiong' of the Apiaceae family. It is warm in nature, bitter in taste, and enters the liver and gallbladder meridians. It can promote qi and relieve depression, activate blood circulation and dispel wind, thereby playing a role in unblocking qi and blood in the head and improving mental state, helping to relieve head discomfort and bad mood caused by depression.

[0030] Prunus japonica kernel is the dried mature seed of Prunus japonica, a shrub of the Rosaceae family. It is mild in nature, pungent, bitter and sweet in taste, and enters the spleen and intestine meridians. It can relieve intestinal dysfunction caused by liver depression and qi stagnation, thereby indirectly alleviating depressive symptoms. Its zinc content is 8-10.5 mg / 100g.

[0031] Oyster meat is the dried meat of the long oyster (Crassostrea gigas), a mollusk of the genus Crassostrea of ​​the family Oysteridae. It is mild in nature, sweet and salty in taste, and enters the heart and liver meridians. It has the effects of nourishing blood and calming the mind, softening and dispersing lumps, and can calm the restlessness, insomnia and restlessness caused by liver depression and fire. Its zinc content is 70-100 mg / 100 g.

[0032] Gastrodia elata is the dried rhizome of the saprophytic herb Gastrodia elata of the Orchidaceae family. It is mild in nature, sweet in taste, and enters the liver meridian. It has the effects of calming wind and stopping convulsions, calming liver yang, dispelling wind and unblocking meridians, relieving depression and relieving fire, and can relieve symptoms such as dizziness, headache, and irritability.

[0033] Polygala root is the dried root of the perennial herb Polygala tenuifolia Willd. of the genus Polygala in the family Polygalaceae. It is warm in nature, bitter and pungent in taste, and belongs to the heart, lung, and kidney meridians. It has the effects of calming the mind and improving intelligence, resolving phlegm and reducing swelling, etc. It can directly improve symptoms such as insomnia, forgetfulness, and restlessness, and helps regulate emotional problems caused by disharmony between the heart and kidney. The polygalasaponins contained have sedative, hypnotic, anticonvulsant, antioxidant, and antidepressant effects.

[0034] Licorice is the dried rhizome of the perennial herb Glycyrrhiza uralensis Fisch. of the genus Glycyrrhiza in the family Leguminosae. It is neutral in nature, sweet in taste, and belongs to the lung, spleen, and stomach meridians. It can regulate the concentration of monoamine neurotransmitters and their receptors, thereby exerting antidepressant effects.

[0035] The present invention also provides a method for preparing the above-mentioned nutritional composition, comprising the following steps:

[0036] (1) Mix Paeonia lactiflora Pall., Angelica sinensis (Oliv.) Diels, Morinda officinalis How, Lycium barbarum L., Eucommia ulmoides Oliv., Salvia miltiorrhiza Bunge, Ligusticum wallichii Franch., Prunus japonica Thunb., Ostrea gigas Thunb., Gastrodia elata Blume, Polygala root, and licorice, and pulverize for 60 - 90 s, preferably 75 s, to obtain a mixture;

[0037] (2) Mix the mixture with water and decoct for 20 - 60 min, preferably 40 min, filter and take the filtrate to obtain an extract;

[0038] (3) Concentrate and dry the extract to obtain the nutritional composition.

[0039] In the present invention, the pulverization in step (1) is ultrafine pulverization, and the particle size of the pulverization is 20 - 50 μm, preferably 40 μm.

[0040] In the present invention, the mass - volume ratio of the mixture to water in step (2) is 10 - 15 g:15 - 22 mL, preferably 12 g:20 mL;

[0041] The decocting temperature in step (2) is 80 - 100 °C, preferably 95 °C.

[0042] In the present invention, the concentration in step (3) is vacuum concentration, the concentration temperature is 20 - 35 °C, preferably 30 °C; the vacuum degree of concentration is 0.02 - 0.08 bar, preferably 0.05 bar; the concentration time is 15 - 60 min, preferably 40 min.

[0043] In the present invention, the drying in step (3) is spray drying, the drying temperature is 135 - 175 °C, preferably 150 °C; the drying time is 5 - 10 s, preferably 8 s.

[0044] The present invention also provides the use of the above-mentioned nutritional composition in the preparation of a health food for relieving and / or improving depression.

[0045] The present invention also provides the use of the nutritional composition prepared by the above-mentioned preparation method in the preparation of a health food for relieving and / or improving depression.

[0046] The technical solutions provided by the present invention will be described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0047] The test animals of the present invention are SPF-grade BALB / c mice, with a body weight of 18-22 g, purchased from the Shanghai Branch of the National Rodent Experimental Animal Seed Center;

[0048] In the electronic system of the present invention, the animal movement trajectory tracking system (EthoVision XT) is purchased from Noldus (Beijing) Information Technology Co., Ltd., and the MedLab-U / 4C501H type biological signal acquisition and processing system is purchased from Nanjing Xinde Intelligent Technology Co., Ltd.;

[0049] In the reagents of the present invention, fluoxetine hydrochloride is purchased from Changzhou No. 4 Pharmaceutical Factory Co., Ltd.

[0050] Example 1: Preparation of the nutritional composition

[0051] (1) Take 27 g of Paeonia lactiflora, 35 g of Angelica sinensis, 25 g of Morinda officinalis, 18 g of Lycium barbarum, 16 g of Eucommia ulmoides, 22 g of Salvia miltiorrhiza, 15 g of Ligusticum chuanxiong, 8 g of Prunus japonica, 12 g of Ostrea gigas, 12 g of Gastrodia elata, 8 g of Polygala tenuifolia, and 5 g of Glycyrrhiza uralensis, mix them evenly, and perform ultrafine grinding for 75 s to obtain a mixture with a particle size of 40 μm;

[0052] (2) After mixing the mixture with 304.5 mL of water, decoct it at 100 °C for 20 min and then filter it, and take the filtrate to obtain an extract;

[0053] (3) Vacuum concentrate the extract at 35 °C and 0.02 bar for 15 min to obtain a concentrated solution, and spray-dry the concentrated solution at 150 °C for 8 s to obtain the nutritional composition.

[0054] Example 2: Preparation of the nutritional composition

[0055] (1) Take 30 g of Paeonia lactiflora, 40 g of Angelica sinensis, 21 g of Morinda officinalis, 20 g of Lycium barbarum, 12 g of Eucommia ulmoides, 24 g of Salvia miltiorrhiza, 11 g of Ligusticum chuanxiong, 10 g of Prunus japonica, 18 g of Ostrea gigas, 16 g of Gastrodia elata, 7 g of Polygala tenuifolia, and 6 g of Glycyrrhiza uralensis, mix them evenly, and perform ultrafine grinding for 90 s to obtain a mixture with a particle size of 50 μm;

[0056] (2) After mixing the mixture with 315.3 mL of water, decoct it at 80 °C for 40 min and then filter. Take the filtrate to obtain the extract;

[0057] (3) Vacuum concentrate the extract at 30 °C and 0.05 bar for 40 min to obtain the concentrated solution. Spray-dry the concentrated solution at 175 °C for 5 s to obtain the nutritional composition.

[0058] Example 3: Preparation of the nutritional composition

[0059] (1) Take 36 g of Paeonia lactiflora, 32 g of Angelica sinensis, 23 g of Morinda officinalis, 19 g of Lycium barbarum, 25 g of Eucommia ulmoides, 20 g of Salvia miltiorrhiza, 13 g of Ligusticum chuanxiong, 12 g of Prunus japonica, 16 g of Ostrea gigas, 14 g of Gastrodia elata, 6 g of Polygala tenuifolia, and 5 g of Glycyrrhiza uralensis, mix them evenly, and ultrafinely pulverize for 60 s to obtain a mixture with a particle size of 40 μm;

[0060] (2) After mixing the mixture with 368.3 mL of water, decoct it at 95 °C for 60 min and then filter. Take the filtrate to obtain the extract;

[0061] (3) Vacuum concentrate the extract at 20 °C and 0.08 bar for 60 min to obtain the concentrated solution. Spray-dry the concentrated solution at 135 °C for 10 s to obtain the nutritional composition.

[0062] Experimental Example 1: Mouse modeling and treatment

[0063] (1) Model establishment: 120 SPF-grade BALB / c mice were selected and divided into 4 groups, namely the model drug administration group, the model control group, the positive group, and the blank group, with 30 mice in each group. Referring to the method disclosed by Fan et al. in the literature (Fan C, Zhu X, Song Q, et al. MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1 / cofilin signaling in rats [J]. Neuropharmacology, 2018, 131: 364-376), unpredictable chronic stress stimulation was performed on the mice in the model drug administration group, the model control group, and the positive group. Specifically, the mice in each group were subjected to different types of stress stimuli, and the stress sources included 4-hour body restraint, 24-hour 45° cage tilt, 24-hour wet bedding, 5-minute cold swimming at 4°C, 5-minute hot swimming at 45°C, 20-minute horizontal shaking, 24-hour fasting, 24-hour water deprivation, 5-minute tail pressure, 24-hour light-dark cycle inversion, and 12-hour night lighting. One of the above stress stimuli was randomly applied to the mice in each group every day, and the same stress stimulus was not applied for 2 consecutive days to minimize the predictability of each stress stimulus. After continuous application for 30 days, a chronic unpredictable mild stress (CUMS) mouse model was obtained. At the same time, the mice in the blank group were not subjected to any stress stimulus treatment.

[0064] (2) Drug administration: After 3 days of adaptive feeding of the mice in each group, the mice in the model drug administration group were intragastrically administered the nutritional composition prepared in Example 1, and the mice in the positive group were intragastrically administered fluoxetine hydrochloride, and the intragastric administration dose was 10 mg / kg of mouse body weight. The mice in the model control group and the blank group were intragastrically administered normal saline, and the intragastric administration dose was 0.2 mL / mouse. Intragastric administration was performed once a day. After continuous intragastric administration for 10 days, a 3-day behavioral experiment evaluation was performed on the mice in each group.

[0065] Experimental example 2: Evaluation of sucrose preference experiment in mice

[0066] The sucrose preference test (SPT) is a reward-based test. Anhedonia or a reduced ability to experience pleasure is a core symptom of depression. Rodents such as mice have a high interest in sweet foods or solutions at birth. In the experiment, if the preference of mice for sugar water decreases, it indicates that they show depressive symptoms. 100 mL of 1% sucrose water and pure water were respectively placed in front of the mice in each group to ensure normal drinking water for the mice in each group. After 2 hours, the consumption of 1% sucrose water and pure water was recorded. The results are shown in Table 1.

[0067] Table 1 Results of sucrose preference experiment in mice

[0068] Group Sucrose preference (%) Model drug administration group 74.25 Model control group 51.33 Positive group 79.36 Blank group 94.00

[0069] The results showed that, compared with the mice in the blank group, the sucrose preference of the mice in the model control group was significantly decreased; compared with the mice in the model control group, the sucrose preference of the mice in the model drug administration group and the positive group was significantly increased. This indicates that the nutritional composition of the present invention can alleviate the depressive symptoms of CUMS model mice.

[0070] Experimental Example 3: Evaluation of the forced swimming test in mice

[0071] In the forced swimming test (FST), a inescapable oppressive environment is provided for mice. The mice try to escape in this environment but cannot, and after a period of time, they will show a "behavioral despair state". The judgment criterion is that when the mice stop struggling and float on the water surface or only make some small movements to keep their heads above the water surface. In the experiment, the longer the time (i.e., the immobility time) that the mice maintain the immobile state, the more severe their depressive degree is. Pour warm water at 25 °C into a glass tank of 40 cm × 20 cm × 40 cm to a water depth of 30 cm, and place each mouse individually in the warm water for 6 min. Use an animal movement trajectory tracking system (EthoVision XT) to record the immobility time starting from the 2nd minute after each mouse enters the water. The results are shown in Table 2.

[0072] Table 2 Results of the forced swimming test in mice

[0073] Group Immobility time (s) Model drug administration group 62.31±4.10 Model control group 98.64±5.15 Positive group 70.33±2.13 Blank group 42.60±3.77

[0074] The results showed that, compared with the mice in the blank group, the immobility time of the mice in the model control group in water was significantly prolonged; compared with the mice in the model control group, the immobility time of the mice in the model drug administration group and the positive group in water was significantly shortened. This indicates that the nutritional composition of the present application can alleviate the behavioral despair state of CUMS model mice in water, thus contributing to alleviating and / or improving depressive-related symptoms.

[0075] Experimental Example 4: Evaluation of the tail suspension test in mice

[0076] In the tail suspension test (TST), after the mice are suspended by their tails and attempt to escape but cannot, they will show a "depressive immobile state" after a period of time. The judgment criterion is that the mice give up struggling and enter a unique static vertical suspension state. In the experiment, the longer the immobility time of the mice, the more severe their depressive degree is. Make each mouse individually hang upside down in a black tail suspension box of 25 cm × 25 cm × 35 cm for 6 min, with the head 5 cm away from the bottom of the box. Use a MedLab-U / 4C501H type biological signal acquisition and processing system to record the immobility time starting from the 2nd minute after each mouse enters the black tail suspension box. The results are shown in Table 3.

[0077] Table 3 Results of the tail suspension test in mice

[0078] Group Immobility time (s) Model drug administration group 54.74±2.99 Model control group 103.81±2.07 Positive group 54.31±4.28 Blank group 46.93±3.26

[0079] The results showed that, compared with the mice in the blank group, the immobility time of the mice in the model control group was significantly prolonged under the tail suspension state; compared with the mice in the model control group, the immobility time of the mice in the model drug administration group and the positive group was significantly shortened under the tail suspension state. It shows that the nutritional composition of the present application can relieve the depressive immobility state of CUMS model mice under the tail suspension state, thus having the effect of relieving and / or improving depression.

[0080] As can be seen from the above examples, the present invention provides a nutritional composition for relieving and / or improving depression, its preparation method and application. The nutritional composition prepared by the present invention has the efficacy of relieving and / or improving depressive symptoms, can relieve the behavioral despair state and depressive immobility state of CUMS model mice, and at the same time can improve the sucrose preference of CUMS model mice.

[0081] The above are only the preferred embodiments of the present invention. It should be pointed out that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A nutritional composition, characterized in that The invention comprises the following components in parts by weight: 18-36 parts of white peony root, 20-40 parts of angelica root, 15-25 parts of Morinda officinalis, 16-22 parts of wolfberry, 10-30 parts of Eucommia ulmoides, 12-24 parts of Salvia miltiorrhiza, 7-15 parts of Ligusticum chuanxiong, 4-12 parts of Prunus mume seeds, 12-22 parts of oyster meat, 10-20 parts of Gastrodia elata, 3-8 parts of Polygala tenuifolia and 3-6 parts of Licorice.

2. The method for preparing the nutritional composition according to claim 1, characterized in that: The steps include: (1) white peony root, angelica root, Morinda officinalis, wolfberry, Eucommia ulmoides, salvia miltiorrhiza, chuanxiong, Prunus mume seed, oyster meat, Gastrodia elata, Polygala tenuifolia, and liquorice are mixed and crushed for 60 to 90 seconds to obtain a mixture; (2) mixing the mixture with water and boiling for 20 to 60 minutes, filtering and collecting the filtrate to obtain an extract; (3) The extract is concentrated and dried to obtain a nutritional composition.

3. The preparation method according to claim 2, characterized in that: The pulverization in step (1) is ultrafine pulverization, and the particle size of the pulverization is 20 to 50 μm.

4. The preparation method according to claim 3, characterized in that: The mass volume ratio of the mixture in step (2) and water is 10-15 g:15-22 mL; The decoction temperature in step (2) is 80-100°C.

5. The preparation method according to claim 4, characterized in that: The concentration in step (3) is vacuum concentration, the concentration temperature is 20-35° C., the concentration vacuum degree is 0.02-0.08 bar, and the concentration time is 15-60 min.

6. The preparation method according to claim 5, characterized in that: The drying in step (3) is spray drying, the drying temperature is 135 to 175° C., and the drying time is 5 to 10 seconds.

7. Use of the nutritional composition according to claim 1 in preparing a health food for alleviating and / or improving depression.

8. Use of the nutritional composition prepared by the preparation method according to any one of claims 2 to 6 in preparing health food for relieving and / or improving depression.