Composition for weight loss and dehumidification, preparation method and application thereof

Abstract

The present invention discloses a composition for weight loss and dampness removal, a preparation method and its application. The composition for weight loss and dampness removal is made of medicinal and edible ingredients such as astragalus, atractylodes, poria, coix seed, hawthorn, tangerine peel, white hyacinth bean, yam, cinnamon bark, amomum villosum, red bean, ginger, galangal, licorice, corn silk, double red rose, etc., which are scientifically and rigorously matched. The preparation process covers key links such as pretreatment, emulsification, homogenization and spray drying. Among them, the preparation process innovatively adopts the synergistic technology of water extraction and alcohol extraction, which can maximize the retention of effective nutrients and bioactive substances in the ingredients and ensure that the product efficacy is fully exerted. Compared with the existing technology, the composition for weight loss and dampness removal of the present invention can not only promote fat decomposition to help weight loss, but also eliminate moisture, dampness and cold, and improve discomfort such as heaviness of limbs. It has significant weight loss and dampness removal effects, accurately regulates body metabolism, has good thermal stability, and is highly safe. It can be applied to the field of weight loss and dampness removal through a variety of dosage forms.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicines, and in particular to a composition for reducing weight and removing dampness, a preparation method and application thereof. Background Art

[0002] With the changes in modern lifestyles, obesity has become a global health problem, affecting an increasing number of people. In recent years, the application of traditional Chinese medicine in the field of weight loss has attracted widespread attention. Due to its advantages such as naturalness and minimal side effects, it has gradually become a hot spot for research and development.

[0003] Although existing traditional Chinese medicine compositions contain a variety of Chinese medicinal herbs with weight loss properties, their weight loss effects remain suboptimal in practice. This is primarily due to the lack of active ingredients in existing formulas that effectively regulate metabolism, inhibit fat synthesis, and promote lipolysis. For example, while existing formulas include some herbs with diuretic and fat-reducing properties (such as coix seed and orientalis), these ingredients have relatively limited mechanisms of action, making it difficult to comprehensively regulate the body's metabolic processes, thereby limiting their weight loss effectiveness. Despite the inclusion of multiple medicinal herbs, existing traditional Chinese medicine compositions have yet to fully optimize the synergistic effects between their ingredients. For example, existing formulas lack ingredients that can effectively regulate endocrine function, suppress appetite, or enhance satiety, resulting in less-than-optimal overall weight loss effects. Furthermore, the mechanisms of action of the ingredients in existing formulas are relatively independent, lacking synergistic design, making it difficult to achieve a "1+1>2" effect. Existing traditional Chinese medicine compositions also lack sustained-release mechanisms, resulting in a short duration of drug action in the body and requiring frequent dosing. This not only affects patient compliance but can also lead to fluctuations in drug concentrations, compromising weight loss effectiveness.

[0004] Chinese invention patent CN114601165A discloses a Chinese medicine composition for weight loss and dampness removal, its preparation process and application. The composition includes a variety of medicinal materials such as Chinese yam, Euryale ferox, Coix seed, Poria cocos, Portulaca oleracea, orange peel, Gardenia jasminoides, Adzuki bean, Emblica officinalis, Daidaihua, Tartary buckwheat, Amomum villosum, Inula japonica flower and Licorice, and has significant weight loss and dampness removal effects. However, although the invention performs well in weight loss and dampness removal, it still has some limitations in practical application. First, the thermal stability of the composition is insufficient, resulting in it being easily degraded under high temperature or long-term storage conditions, affecting the effectiveness and stability of the product. Secondly, the composition still has room for improvement in weight loss effect, especially in terms of its mechanism of action in inhibiting fat synthesis and promoting fat decomposition. In addition, the preparation process of the invention is relatively complicated, which limits its large-scale production and application. Summary of the Invention

[0005] In order to address the deficiencies in the prior art, the present invention aims to provide a weight-loss and dampness-eliminating composition, a preparation method and applications thereof.

[0006] In order to achieve the above-mentioned object of the invention, the present invention adopts the following technical solutions:

[0007] A composition for reducing weight and removing dampness, comprising the following raw materials in parts by weight:

[0008] 15-20 parts of astragalus, 10-15 parts of white atractylodes, 10-15 parts of poria, 15-20 parts of coix seed, 15-20 parts of hawthorn, 10-15 parts of dried tangerine peel, 5-10 parts of white hyacinth bean, 15-20 parts of yam, 1-3 parts of cinnamon bark, 5-10 parts of amomum villosum, 8-12 parts of red bean, 5-10 parts of ginger, 3-5 parts of galangal, 0.1-0.3 parts of liquorice, 3-5 parts of corn silk, 5-10 parts of double red rose, 0.5-2 parts of flavoring agent and 0.2-0.6 parts of compound additive.

[0009] The preparation method of the compound additive is as follows, in parts by weight:

[0010] S1, adding 120-180 parts of the main material, 40-60 parts of the auxiliary material and 4-6 parts of calcium propionate to 1800-2200 parts of water at a temperature of 60-70° C., and fully dissolving them at a stirring speed of 15000-18000 r / min to prepare a pretreated material;

[0011] S2, adding 40-60 parts of an antioxidant to the pretreated material prepared in step S1, stirring at a speed of 18000-22000 r / min for 10-30 minutes for emulsification to obtain an emulsion, dissolving 8-12 parts of sodium citrate in 180-220 parts of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 20-40° C., and stirring at a speed of 14000-16000 r / min for 10-30 minutes to obtain a post-treated material;

[0012] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 30-50 MPa to form a homogenized liquid. Subsequently, the homogenized liquid is spray-dried. The atomization pressure of the spray drying is set to 1.5-2 MPa, the air inlet temperature is 160-180°C, and the air outlet temperature is 80-100°C to obtain a compound additive.

[0013] The flavoring agent is selected from at least one of honey, sucrose, glucose, fructose, sucralose, aspartame, and erythritol.

[0014] The antioxidant is at least one of butylated hydroxyanisole, tert-butylhydroquinone, propyl gallate, vitamin E, and tea polyphenols.

[0015] The main ingredient is at least one of gum arabic, carboxymethyl starch, acarbose, gynostemma pentaphyllum extract, and ginsenoside Rb1.

[0016] The auxiliary material is at least one of glucomannan, hydroxyethyl cellulose and pullulan.

[0017] The preparation method of the composition for reducing weight and removing dampness is as follows:

[0018] Step 1. Prepare the herbs: weigh astragalus, white atractylodes, poria, coix seed, hawthorn, tangerine peel, white hyacinth bean, yam, cinnamon bark, amomum villosum, red bean, ginger, galangal, licorice, corn silk, and double red rose, clean them, cut them into 0.5-3 cm pieces, and dry them in a cool place.

[0019] Step 2, water extraction: Astragalus, Atractylodes macrocephala, Poria cocos, Coix seed, hawthorn, tangerine peel, white hyacinth bean, yam, red bean, ginger, galangal, licorice, corn silk, and double red rose are put into a water extraction tank, and water is added, the weight of the water is 2 to 8 times the weight of the medicinal materials, and the mixture is heated to 95 to 100° C. under closed conditions, and the mixture is kept warm for 1 to 3 hours, and the filtrate and the residue are obtained by filtering; the residue is further added with water, the weight of the water is 2 to 8 times the weight of the residue, and the mixture is heated to 95 to 100° C. under closed conditions again, and the mixture is kept warm for 1 to 3 hours, and the filtrate and the residue are obtained by filtering; the residue is further added with water, the weight of the water is 2 to 8 times the weight of the residue, and the mixture is heated to 95 to 100° C. under closed conditions again, and the mixture is kept warm for 1 to 3 hours, and the filtrate and the residue are obtained by filtering, the three filtrates are combined, and the filtrates are concentrated under reduced pressure to obtain a water extract concentrate with a relative density of 1.05 to 1.3 g / mL;

[0020] Step 3, alcohol extraction: putting cinnamon bark and Amomum villosum into an alcohol extraction tank, adding 75-85wt% ethanol aqueous solution, the weight of the ethanol aqueous solution is 2-20 times the weight of the medicinal materials, heating to boiling under closed conditions, keeping warm for extraction for 1-3 hours, and filtering to obtain a filtrate and medicinal residues; adding 75-85wt% ethanol aqueous solution to the medicinal residues, the weight of the ethanol aqueous solution is 2-20 times the weight of the medicinal residues, heating to boiling under closed conditions, keeping warm for extraction for 1-3 hours, and filtering to obtain a filtrate and medicinal residues; adding 75-85wt% ethanol aqueous solution to the medicinal residues, the weight of the ethanol aqueous solution is 2-20 times the weight of the medicinal residues, heating to boiling under closed conditions, keeping warm for extraction for 1-3 hours, combining the three filtrates, collecting the supernatant, and recovering anhydrous ethanol under reduced pressure to obtain an alcohol-extracted concentrate with a relative density of 1.05-1.3 g / mL;

[0021] Step 4, concentration and mixing: the water extract concentrate and the alcohol extract concentrate are mixed, flavoring agents and compound additives are added, and the mixture is concentrated to a relative density of 1.05-1.3 g / mL to prepare a weight-loss and dampness-removing composition.

[0022] The weight-loss and dampness-eliminating composition is used in weight-loss and dampness-eliminating.

[0023] The weight-loss and dampness-eliminating composition is in solid form, semi-solid form or liquid form.

[0024] The composition for reducing weight and removing dampness is in the form of decoction pieces, decoction, powder, oral liquid, paste, granule, tablet or capsule.

[0025] This weight-loss and dampness-removing composition exhibits excellent thermal stability and high safety, allowing for flexible formulation into a variety of specialized dietary food formulations. Powders are easy to prepare and absorb; liquid formulations are convenient to take and rapidly absorbed; and compressed candies offer a pleasant taste and are convenient for consumers to carry around for consumption. These diverse formulations are widely applicable to health care and daily diet scenarios for weight loss and dampness-removal, providing a safe, effective, and highly promising innovative food solution for addressing obesity and dampness-related health issues.

[0026] In terms of mechanism of action, this weight loss and dampness removal composition has unique effects on dampness and dampness-cold. From the perspective of traditional Chinese medicine theory, dampness and dampness-cold in the body are mostly caused by abnormal spleen and stomach transportation and transformation, and obstructed water metabolism. The ingredients in the composition, such as Poria cocos, Coix seed, and red bean, have the effect of promoting water and eliminating dampness, which can promote the discharge of excess water in the body and improve the state of water stagnation; Atractylodes macrocephala, Chinese yam, and white hyacinth bean can strengthen the spleen and replenish qi, enhance the transportation and transformation function of the spleen and stomach, and regulate water metabolism from the root; while cinnamon, galangal, and ginger are warm in nature, which can warm yang and dispel cold, dispel dampness and cold in the body, invigorate yang energy, and make the circulation of qi and blood smoother. Through the synergistic effect of multiple ingredients, the body's metabolism is precisely regulated, which can not only effectively promote fat decomposition and achieve effective weight management, but also effectively eliminate dampness, dampness and cold in the body, and improve uncomfortable symptoms such as heavy limbs, joint pain, and loose stools caused by dampness and cold blockage.

[0027] Astragalus is sweet in taste and slightly warm in nature, and enters the lung and spleen meridians. It has the effects of replenishing qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, and relieving stagnation and relieving numbness.

[0028] Atractylodes macrocephala tastes sweet and bitter, is warm in nature, and enters the spleen and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, drying dampness and promoting diuresis, and stopping sweating.

[0029] Poria cocos is sweet, light, neutral in nature, and enters the heart, spleen, and kidney meridians. It has the effects of promoting diuresis and dispelling dampness, strengthening the spleen and calming the mind.

[0030] Coix seed tastes sweet, light, and cool in nature, and enters the spleen, stomach, and lung meridians. It has the effects of promoting diuresis and dispelling dampness, strengthening the spleen and stopping diarrhea, removing numbness, draining pus, and detoxifying and dispersing nodules.

[0031] Hawthorn tastes sour and sweet, is slightly warm in nature, and enters the spleen, stomach, and liver meridians. It has the effects of promoting digestion and strengthening the stomach, promoting qi and dispersing blood stasis, and clearing turbidity and reducing lipids.

[0032] Tangerine peel is pungent and bitter in taste, warm in nature, and enters the lung and spleen meridians. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm.

[0033] White lentils are sweet, slightly warm, and enter the spleen and stomach meridians. They have the effects of strengthening the spleen and eliminating dampness, harmonizing the middle and relieving heat.

[0034] Chinese yam is sweet and flat in taste, and enters the spleen, lung and kidney meridians. It has the effects of nourishing the spleen and stomach, promoting fluid production and benefiting the lungs, and nourishing the kidneys and astringing essence.

[0035] Cinnamon bark is pungent in taste and enters the kidney, spleen, heart, and liver meridians. It replenishes fire and yang, guides fire back to its source, dispels cold and relieves pain, and warms and unclogs the meridians.

[0036] Amomum villosum is pungent and warm in taste, and enters the spleen, stomach, and kidney meridians. It has the effects of removing dampness and promoting qi, warming the middle and stopping diarrhea, and calming the fetus.

[0037] Red bean tastes sweet, sour and flat, and enters the heart and small intestine meridians. It can promote diuresis and reduce swelling, detoxify and discharge pus.

[0038] Ginger is pungent and slightly warm, and enters the lung, stomach, and spleen meridians. It can dispel cold, warm the middle and stop vomiting, and warm the lungs and stop coughing.

[0039] Galangal is pungent and hot in nature and enters the spleen and stomach meridians. It warms the stomach and stops vomiting, dispels cold and relieves pain.

[0040] Licorice root is sweet and neutral in taste, and enters the heart, lung, spleen, and stomach meridians. It nourishes the spleen and replenishes qi, clears away heat and detoxifies, eliminates phlegm and relieves cough, relieves pain, and harmonizes various medicines.

[0041] Corn silk is sweet and neutral in taste, and enters the liver, gallbladder, and bladder meridians. It has diuretic and detumescent effects, clears the liver and promotes bile secretion.

[0042] Double red rose tastes sweet, slightly bitter, and warm, and enters the liver and spleen meridians. It promotes qi and relieves depression, harmonizes blood circulation, and relieves pain.

[0043] These Chinese medicinal materials work synergistically in the present invention, and jointly play the role of weight loss and dampness removal through multiple functions such as strengthening the spleen and removing dampness, promoting diuresis and removing dampness, promoting digestion and strengthening the stomach, regulating qi and strengthening the spleen, etc.

[0044] In the method for preparing the compound additive of the present invention, the functions of each substance are as follows:

[0045] Ginsenoside Rb1, the main active ingredient, exhibits significant biological activity, regulating metabolic processes, inhibiting fat synthesis, and promoting fat breakdown, thereby playing a positive role in weight loss. Furthermore, it possesses antioxidant and immunomodulatory properties, contributing to the overall efficacy of the compounded supplement.

[0046] Pullulan is a natural polysaccharide with excellent film-forming and coating properties. It forms a stable coating structure, protecting active ingredients such as ginsenoside Rb1 and vitamin E from degradation at high temperatures and during storage. Pullulan also exhibits excellent emulsifying and stabilizing properties, enhancing the physical stability of compound additives.

[0047] Calcium propionate is a commonly used preservative that effectively prevents microbial contamination during the preparation and storage of compound additives, extending the shelf life of the product. Once dissolved in water, it can be evenly distributed throughout the compound additive, providing a preservative effect.

[0048] Vitamin E is a fat-soluble antioxidant that can effectively scavenge free radicals and protect the composition from oxidative damage.

[0049] Sodium citrate acts as a buffer and emulsifier, adjusting the pH of compound additives, enhancing the stability of the emulsion, and preventing component separation. It can also form a stable complex with calcium ions, further enhancing the stability of compound additives.

[0050] These substances work synergistically during the preparation of compound additives. Through coating, sustained release, anti-oxidation, and anti-corrosion functions, they significantly improve the thermal stability, antioxidant properties, and weight loss effects of the compound additives. At the same time, they extend the shelf life of the product, enabling it to exhibit excellent performance in weight loss and dehumidification applications.

[0051] Compared with the existing technology, it has the following beneficial effects:

[0052] 1) This invention utilizes an innovative additive design, utilizing a coating structure formed by the main and auxiliary ingredients, to effectively protect the antioxidant's stability under high-temperature conditions, enabling a sustained-release effect. This design significantly improves the thermal stability of the weight-loss and dampness-removing composition, resolving the thermal stability issues of existing technologies and ensuring that the product maintains its excellent quality during storage and use.

[0053] 2) The present invention optimizes the ingredients of compound additives, regulates metabolic processes, inhibits fat synthesis and promotes fat decomposition, and performs better in weight loss effect, providing a more effective solution for weight loss and dehumidification while maintaining good safety.

[0054] 3) The present invention's weight-loss and dampness-removing composition utilizes a combined aqueous and alcohol extraction process to maximize the retention of the active ingredients in the medicinal materials. The coating and sustained-release properties of the compounded additives enhance the product's antioxidant and stability. Furthermore, the present invention offers a variety of dosage forms, enhancing the product's applicability and market competitiveness. DETAILED DESCRIPTION

[0055] Main sources of substances:

[0056] Astragalus, a commercially available product, originates from Minxian County, Gansu Province.

[0057] Atractylodes macrocephala and Poria cocos are commercially purchased products produced in Lijiang, Yunnan.

[0058] Job's tears, a commercially available product, originates from Qichun, Hubei.

[0059] Hawthorn, a commercially available product, originates from Chengde, Hebei.

[0060] Tangerine peel, a commercially available product, originates from Nan'an, Fujian.

[0061] White lentils, commercially available products, originate from Chuxiong, Yunnan.

[0062] Chinese yam, a commercially available product, originates from Jiaozuo, Henan Province.

[0063] Cinnamon, a commercially available product, originates from Fangchenggang, Guangxi.

[0064] Amomum villosum, a commercially available product, originates from Yangchun, Guangdong.

[0065] Red bean, commercially available product, produced in Baicheng, Jilin.

[0066] Ginger, commercially available product, produced in Laiwu, Shandong.

[0067] Galangal, a commercially available product, originates from Zhanjiang, Guangdong.

[0068] Licorice, commercially available product, produced in Kashgar, Xinjiang.

[0069] Corn silk, commercially available product, produced in Gongzhuling, Jilin.

[0070] Double red rose, commercially available product, produced in Pingyin, Shandong.

[0071] Gynostemma pentaphyllum extract, single product number: HEP001, Ankang Kangyuan Pharmaceutical Technology Co., Ltd.

[0072] Pullulan, product number: 89602331, grade: food grade, Qingdao Hivison Biotechnology Co., Ltd.

[0073] Vitamin E, product number: S57, Shandong Shanlancheng Pharmaceutical Co., Ltd.

[0074] The remaining raw materials in the examples and comparative examples of the present invention are all commercially available products.

[0075] The design idea of ​​the present invention is to develop a Chinese medicine preparation with significant weight loss and dampness removal effects by optimizing the formula and preparation process of the composition and combining the innovative design of compound additives. Specifically, the present invention maximizes the retention of the active ingredients in the medicinal materials by selecting traditional Chinese medicine ingredients and adopting an extraction process that combines water extraction and alcohol extraction. At the same time, compound additives are introduced to utilize their coating and sustained-release properties to enhance the antioxidant and thermal stability of the composition, further improving the stability and efficacy of the product. In addition, by adjusting the ingredients of the compound additives, the weight loss and weight reduction effects are optimized, so that while maintaining thermal stability, the weight loss effect is significantly improved, thereby providing a safe and effective Chinese medicine solution for weight loss and dampness removal.

[0076] Example 1

[0077] A method for preparing a composition for reducing weight and removing dampness is as follows:

[0078] Step 1. Prepare the medicinal materials: weigh 180g of Astragalus, 120g of Atractylodes, 120g of Poria, 180g of Coix Seed, 180g of Hawthorn, 130g of Tangerine Peel, 80g of White Hyacinth Bean, 120g of Chinese Yam, 20g of Cinnamon Bark, 70g of Amomum Villosum, 100g of Red Bean, 80g of Ginger, 40g of Alpinia officinalis, 2g of Licorice, 40g of Corn Silk, and 80g of Double Red Rose, clean them, cut into 1cm pieces, and dry them in a cool place;

[0079] Step 2, water extraction: Astragalus, Atractylodes macrocephala, Poria cocos, Coix seed, hawthorn, tangerine peel, white hyacinth bean, yam, red bean, ginger, galangal, licorice, corn silk, and double red rose are put into a water extraction tank, 5000g of water is added, and the mixture is heated to 100°C under closed conditions, kept warm for 2h, and filtered to obtain a filtrate and a medicinal residue; 4000g of water is added to the medicinal residue, and the mixture is heated to 100°C under closed conditions again, kept warm for 2h, and filtered to obtain a filtrate and a medicinal residue; 4000g of water is added to the medicinal residue, and the mixture is heated to 100°C under closed conditions again, kept warm for 1h, and filtered to obtain a filtrate and a medicinal residue, the three filtrates are combined, and concentrated under reduced pressure to obtain a water extract concentrate with a relative density of 1.1g / mL;

[0080] Step 3, alcohol extraction: Cinnamon bark and Amomum villosum are put into an alcohol extraction tank, 5000g of 80wt% ethanol aqueous solution is added, and the mixture is heated to boiling under closed conditions, kept warm for 2h, and filtered to obtain a filtrate and a medicinal residue; 4000g of 80wt% ethanol aqueous solution is added to the medicinal residue, and the mixture is heated to boiling under closed conditions, kept warm for 2h, and the mixture is filtered to obtain a filtrate and a medicinal residue; 4000g of 80wt% ethanol aqueous solution is added to the medicinal residue, and the mixture is heated to boiling under closed conditions, kept warm for 2h, and the three filtrates are combined, the supernatant is collected, and anhydrous ethanol is recovered under reduced pressure to obtain an alcohol-extracted concentrate with a relative density of 1.1g / mL;

[0081] Step 4, concentration and mixing: the water extract concentrate and the alcohol extract concentrate are mixed, 10 g of sucrose and 4 g of compound additives are added, and the mixture is concentrated to a relative density of 1.2 g / mL to prepare a weight-loss and dampness-removing composition.

[0082] The preparation method of the compound additive is as follows:

[0083] S1, adding 150g of Gynostemma pentaphyllum extract, 50g of pullulan and 5g of calcium propionate to 2000g of water at a temperature of 65°C, and fully dissolving them at a stirring speed of 16000r / min to prepare a pretreated material;

[0084] S2, adding 50g of vitamin E to the pretreated material prepared in step S1, stirring at a speed of 20000r / min for 20 minutes for emulsification to obtain an emulsion, dissolving 10g of sodium citrate in 200g of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 30°C, and stirring at a speed of 15000r / min for 20 minutes to obtain a post-treated material;

[0085] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 40 MPa to form a homogenous liquid. Subsequently, the homogenous liquid is spray-dried, and the atomization pressure of the spray drying is set to 1.8 MPa, the air inlet temperature is 170°C, and the air outlet temperature is 90°C to obtain a compound additive.

[0086] Example 2

[0087] The preparation method of a composition for weight loss and dehumidification is basically the same as that of Example 1, the only difference being the preparation method of the compound additive.

[0088] The preparation method of the compound additive is as follows:

[0089] S1. Add 150 g of carboxymethyl starch, 50 g of pullulan and 5 g of calcium propionate to 2000 g of water at a temperature of 65° C. and fully dissolve them at a stirring speed of 16000 r / min to prepare a pretreated material;

[0090] S2, adding 50g of vitamin E to the pretreated material prepared in step S1, stirring at a speed of 20000r / min for 20 minutes for emulsification to obtain an emulsion, dissolving 10g of sodium citrate in 200g of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 30°C, and stirring at a speed of 15000r / min for 20 minutes to obtain a post-treated material;

[0091] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 40 MPa to form a homogenous liquid. Subsequently, the homogenous liquid is spray-dried, and the atomization pressure of the spray drying is set to 1.8 MPa, the air inlet temperature is 170°C, and the air outlet temperature is 90°C to obtain a compound additive.

[0092] Example 3

[0093] The preparation method of a composition for weight loss and dehumidification is basically the same as that of Example 1, the only difference being the preparation method of the compound additive.

[0094] The preparation method of the compound additive is as follows:

[0095] S1. Add 150 g of gum arabic, 50 g of pullulan and 5 g of calcium propionate to 2000 g of water at a temperature of 65° C. and fully dissolve them at a stirring speed of 16000 r / min to prepare a pretreated material;

[0096] S2, adding 50g of vitamin E to the pretreated material prepared in step S1, stirring at a speed of 20000r / min for 20 minutes for emulsification to obtain an emulsion, dissolving 10g of sodium citrate in 200g of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 30°C, and stirring at a speed of 15000r / min for 20 minutes to obtain a post-treated material;

[0097] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 40 MPa to form a homogenous liquid. Subsequently, the homogenous liquid is spray-dried, and the atomization pressure of the spray drying is set to 1.8 MPa, the air inlet temperature is 170°C, and the air outlet temperature is 90°C to obtain a compound additive.

[0098] Example 4

[0099] The preparation method of a composition for weight loss and dehumidification is basically the same as that of Example 1, the only difference being the preparation method of the compound additive.

[0100] The preparation method of the compound additive is as follows:

[0101] S1, adding 150g of Gynostemma pentaphyllum extract, 50g of hydroxyethyl cellulose and 5g of calcium propionate to 2000g of water at a temperature of 65°C, and fully dissolving them at a stirring speed of 16000r / min to prepare a pretreated material;

[0102] S2, adding 50g of vitamin E to the pretreated material prepared in step S1, stirring at a speed of 20000r / min for 20 minutes for emulsification to obtain an emulsion, dissolving 10g of sodium citrate in 200g of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 30°C, and stirring at a speed of 15000r / min for 20 minutes to obtain a post-treated material;

[0103] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 40 MPa to form a homogenous liquid. Subsequently, the homogenous liquid is spray-dried, and the atomization pressure of the spray drying is set to 1.8 MPa, the air inlet temperature is 170°C, and the air outlet temperature is 90°C to obtain a compound additive.

[0104] Example 5

[0105] The preparation method of a composition for weight loss and dehumidification is basically the same as that of Example 1, the only difference being the preparation method of the compound additive.

[0106] The preparation method of the compound additive is as follows:

[0107] S1, adding 150g of Gynostemma pentaphyllum extract, 50g of glucomannan and 5g of calcium propionate to 2000g of water at a temperature of 65°C, and fully dissolving them at a stirring speed of 16000r / min to prepare a pretreated material;

[0108] S2, adding 50g of vitamin E to the pretreated material prepared in step S1, stirring at a speed of 20000r / min for 20 minutes for emulsification to obtain an emulsion, dissolving 10g of sodium citrate in 200g of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 30°C, and stirring at a speed of 15000r / min for 20 minutes to obtain a post-treated material;

[0109] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 40 MPa to form a homogenous liquid. Subsequently, the homogenous liquid is spray-dried, and the atomization pressure of the spray drying is set to 1.8 MPa, the air inlet temperature is 170°C, and the air outlet temperature is 90°C to obtain a compound additive.

[0110] Example 6

[0111] The preparation method of a composition for weight loss and dehumidification is basically the same as that of Example 1, the only difference being the preparation method of the compound additive.

[0112] The preparation method of the compound additive is as follows:

[0113] S1. Add 150 g of ginsenoside Rb1, 50 g of pullulan, and 5 g of calcium propionate to 2000 g of water at 65° C. and fully dissolve them at a stirring speed of 16000 r / min to prepare a pretreated material;

[0114] S2, adding 50g of vitamin E to the pretreated material prepared in step S1, stirring at a speed of 20000r / min for 20 minutes for emulsification to obtain an emulsion, dissolving 10g of sodium citrate in 200g of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 30°C, and stirring at a speed of 15000r / min for 20 minutes to obtain a post-treated material;

[0115] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 40 MPa to form a homogenous liquid. Subsequently, the homogenous liquid is spray-dried, and the atomization pressure of the spray drying is set to 1.8 MPa, the air inlet temperature is 170°C, and the air outlet temperature is 90°C to obtain a compound additive.

[0116] Comparative Example 1

[0117] The preparation method of a composition for weight loss and dehumidification is basically the same as that of Example 1, the only difference being the preparation method of the compound additive.

[0118] The preparation method of the compound additive is as follows:

[0119] S1. Add 150 g of sodium starch octenylsuccinate, 50 g of pullulan and 5 g of calcium propionate to 2000 g of water at a temperature of 65° C. and fully dissolve them at a stirring speed of 16000 r / min to prepare a pretreated material;

[0120] S2, adding 50g of vitamin E to the pretreated material prepared in step S1, stirring at a speed of 20000r / min for 20 minutes for emulsification to obtain an emulsion, dissolving 10g of sodium citrate in 200g of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 30°C, and stirring at a speed of 15000r / min for 20 minutes to obtain a post-treated material;

[0121] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 40 MPa to form a homogenous liquid. Subsequently, the homogenous liquid is spray-dried, and the atomization pressure of the spray drying is set to 1.8 MPa, the air inlet temperature is 170°C, and the air outlet temperature is 90°C to obtain a compound additive.

[0122] Comparative Example 2

[0123] The preparation method of a composition for weight loss and dehumidification is basically the same as that of Example 1, the only difference being the preparation method of the compound additive.

[0124] The preparation method of the compound additive is as follows:

[0125] S1, adding 150g of Gynostemma pentaphyllum extract, 50g of isomaltooligosaccharide and 5g of calcium propionate to 2000g of water at a temperature of 65°C, and fully dissolving them at a stirring speed of 16000r / min to prepare a pretreated material;

[0126] S2, adding 50g of vitamin E to the pretreated material prepared in step S1, stirring at a speed of 20000r / min for 20 minutes for emulsification to obtain an emulsion, dissolving 10g of sodium citrate in 200g of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 30°C, and stirring at a speed of 15000r / min for 20 minutes to obtain a post-treated material;

[0127] S3. The post-processed product is sent to a high-pressure homogenizer and homogenized twice at a pressure of 40 MPa to form a homogenous liquid. Subsequently, the homogenous liquid is spray-dried, and the atomization pressure of the spray drying is set to 1.8 MPa, the air inlet temperature is 170°C, and the air outlet temperature is 90°C to obtain a compound additive.

[0128] Comparative Example 3

[0129] The preparation method of a composition for weight loss and dehumidification is basically the same as that of Example 1, the only difference being that the compound additive is not added.

[0130] Test Example 1

[0131] Stability testing

[0132] The weight loss and dampness removal compositions prepared in the examples and comparative examples were sealed and placed in an environment at 48±1°C for two weeks. After returning to room temperature, the appearance was compared with a sample stored at room temperature (25±3°C) for two weeks. The test results are shown in Table 1.

[0133] Test Example 2

[0134] Acute toxicity test in mice (maximum tolerated dose method)

[0135] 1. Experimental animals: 100 healthy Kunming mice (18-22 g) were provided by the China Food and Drug Administration (CFDA), with ten mice per group, half male and half female.

[0136] 2. Feed source: The basic feed is produced by Beijing Huafukang Biotechnology Co., Ltd.

[0137] 3. Test method: Weigh 20 g of the weight-loss and dehumidifying composition prepared in the examples and comparative examples, and gavage at a dose of 10.0 g / kg body weight. The second gavage was performed after an interval of 6 hours, and the gavage was performed twice a day, with a cumulative dose of 20.0 g / kg body weight. The control group was gavaged with an equal amount of water.

[0138] 4. Observation indicators: Observe the mice for 14 consecutive days and record their condition, weight changes, and signs of poisoning.

[0139]

[0140] During the 14-day observation period, the animals were in normal condition, with no signs of poisoning or death. On the 15th day, the animals were sacrificed for a gross autopsy, which revealed no significant abnormalities in their major organs. According to the acute toxicity classification standard, the composition of the present invention is classified as non-toxic.

[0141] It can be seen from the data of Test Example 1 that the weight loss and dampness removal composition prepared in Example 1 has good thermal stability.

[0142] In Example 1, the combination of Gynostemma pentaphyllum extract, pullulan and calcium propionate forms a unique coating structure during the compounding process. This structure can effectively coat the vitamin E antioxidant, so that it has a sustained-release effect under high temperature conditions. As an antioxidant, vitamin E can be gradually released, thereby continuously exerting an antioxidant effect and protecting the active ingredients in the composition from high-temperature oxidative damage. In contrast, although the carboxymethyl starch used in Example 2, the gum arabic in Example 3, and the sodium starch octenylsuccinate in Comparative Example 1 also have certain coating capabilities, the structures they form are relatively weak in the coating and sustained-release effects on vitamin E under high temperature conditions. Therefore, the compounded additive of Example 1 exhibits more superior antioxidant properties and thermal stability under high temperature conditions, significantly improving the stability of the composition.

[0143] In the present invention, the compound additive used in Example 1 uses pullulan as the main component, which exhibits superior thermal stability compared to the hydroxyethyl cellulose in Example 4, the glucomannan in Example 5, and the oligomaltodextrose in Comparative Example 2. Pullulan is a natural polysaccharide with a unique molecular structure and good film-forming properties. It can form a stable coating structure with Gynostemma pentaphyllum extract and calcium propionate. This structure not only effectively encapsulates the vitamin E antioxidant, but also gives it a sustained-release property, allowing it to be gradually released under high temperature conditions and continuously exert its antioxidant effect, thereby significantly improving the antioxidant and thermal stability of the composition. In contrast, although other polysaccharide materials (such as hydroxyethyl cellulose, glucomannan, and oligomaltodextrose) also have certain encapsulation capabilities, their molecular structure and film-forming properties are inferior to pullulan, resulting in weaker protection and sustained-release effects on vitamin E under high temperature environments, which in turn affects the overall stability of the composition. Therefore, the use of pullulan in the compound additive is a key factor in the excellent thermal stability of the weight loss and dehumidification composition in Example 1.

[0144] In the present invention, Example 6 uses a compound additive prepared by compounding ginsenoside Rb1 with pullulan. Compared with the combination of Gynostemma pentaphyllum extract and pullulan in Example 1, it exhibits considerable thermal stability and performs better in weight loss effect. The mechanism of this phenomenon may be related to the unique physiological activity of ginsenoside Rb1. Ginsenoside Rb1 is a component with significant biological activity. It is known that it can regulate metabolic processes, inhibit fat synthesis, and promote fat decomposition, thereby playing a positive role in weight loss. In addition, pullulan, as an excellent film-forming material, can form a stable coating structure with ginsenoside Rb1, protecting its active ingredients from destruction during high temperature and storage, while achieving a sustained release effect. This structure not only retains the antioxidant properties of vitamin E, further improves the thermal stability of the composition, but also allows the weight loss effect of ginsenoside Rb1 to be fully utilized. Therefore, while maintaining thermal stability, the compound additive in Example 6 significantly enhances the weight loss effect of the composition through the metabolic regulation of ginsenoside Rb1.

[0145] In the actual production process based on this formula, it is allowed to adjust the formula composition by using equivalent substitution methods; at the same time, other ingredients can be added according to specific production conditions and needs without affecting the core functions, performance and patent validity of the technical solution involved in this patent.

Claims

1. A composition for reducing weight and removing dampness, characterized in that: It is composed of the following raw materials in parts by weight: 15-20 parts of Astragalus, 10-15 parts of Atractylodes, 10-15 parts of Poria, 15-20 parts of Coix seeds, 15-20 parts of Hawthorn, 10-15 parts of Tangerine peel, 5-10 parts of White Lablab, 15-20 parts of Chinese Yam, 1-3 parts of Cinnamon, 5-10 parts of Amomum villosum, 8-12 parts of Adzuki Bean, 5-10 parts of Ginger, 3-5 parts of Galangal, 0.1-0.3 parts of Licorice, 3-5 parts of Corn Silk, 5-10 parts of Double Red Rose, 0.5-2 parts of Flavoring Agents, and 0.2-0.6 parts of Compound Additives; The preparation method of the compound additive is as follows, in parts by weight: S1, adding 120-180 parts of the main material, 40-60 parts of the auxiliary material and 4-6 parts of calcium propionate to 1800-2200 parts of water at a temperature of 60-70° C., and fully dissolving them at a stirring speed of 15000-18000 r / min to prepare a pretreated material; S2, adding 40-60 parts of an antioxidant to the pretreated material prepared in step S1, stirring at a speed of 18000-22000 r / min for 10-30 minutes for emulsification to obtain an emulsion, dissolving 8-12 parts of sodium citrate in 180-220 parts of water to prepare a sodium citrate aqueous solution, then adding the emulsion to the sodium citrate aqueous solution, heating to 20-40° C., and stirring at a speed of 14000-16000 r / min for 10-30 minutes to obtain a post-treated material; S3, sending the post-processed product into a high-pressure homogenizer and performing two homogenization treatments at a pressure of 30-50 MPa to form a homogenous liquid, and then spray drying the homogenous liquid, with the atomization pressure of the spray drying being set to 1.5-2 MPa, the inlet air temperature being 160-180°C, and the outlet air temperature being 80-100°C, to obtain a compound additive; The preparation method of the composition for reducing weight and removing dampness is as follows: Step 1. Prepare the herbs: weigh astragalus, white atractylodes, poria, coix seed, hawthorn, tangerine peel, white hyacinth bean, yam, cinnamon bark, amomum villosum, red bean, ginger, galangal, licorice, corn silk, and double red rose, clean them, cut them into 0.5-3 cm pieces, and dry them in a cool place. Step 2, water extraction: Astragalus, Atractylodes macrocephala, Poria cocos, Coix seed, hawthorn, tangerine peel, white hyacinth bean, yam, red bean, ginger, galangal, licorice, corn silk, and double red rose are put into a water extraction tank, and water is added, the weight of the water is 2 to 8 times the weight of the medicinal materials, and the mixture is heated to 95 to 100° C. under closed conditions, and the mixture is kept warm for 1 to 3 hours, and the filtrate and the residue are obtained by filtering; the residue is further added with water, the weight of the water is 2 to 8 times the weight of the residue, and the mixture is heated to 95 to 100° C. under closed conditions again, and the mixture is kept warm for 1 to 3 hours, and the filtrate and the residue are obtained by filtering; the residue is further added with water, the weight of the water is 2 to 8 times the weight of the residue, and the mixture is heated to 95 to 100° C. under closed conditions again, and the mixture is kept warm for 1 to 3 hours, and the filtrate and the residue are obtained by filtering, the three filtrates are combined, and the filtrates are concentrated under reduced pressure to obtain a water extract concentrate with a relative density of 1.05 to 1.3 g / mL; Step 3, alcohol extraction: putting cinnamon bark and Amomum villosum into an alcohol extraction tank, adding 75-85wt% ethanol aqueous solution, the weight of the ethanol aqueous solution is 2-20 times the weight of the medicinal materials, heating to boiling under closed conditions, keeping warm for extraction for 1-3 hours, and filtering to obtain a filtrate and medicinal residues; adding 75-85wt% ethanol aqueous solution to the medicinal residues, the weight of the ethanol aqueous solution is 2-20 times the weight of the medicinal residues, heating to boiling under closed conditions, keeping warm for extraction for 1-3 hours, and filtering to obtain a filtrate and medicinal residues; adding 75-85wt% ethanol aqueous solution to the medicinal residues, the weight of the ethanol aqueous solution is 2-20 times the weight of the medicinal residues, heating to boiling under closed conditions, keeping warm for extraction for 1-3 hours, combining the three filtrates, collecting the supernatant, and recovering anhydrous ethanol under reduced pressure to obtain an alcohol-extracted concentrate with a relative density of 1.05-1.3 g / mL; Step 4, concentration and mixing: mixing the water extract concentrate and the alcohol extract concentrate, adding flavoring agents and compound additives, and concentrating to a relative density of 1.05-1.3 g / mL to prepare a composition; The antioxidant is vitamin E; The main ingredient is at least one of gum arabic, carboxymethyl starch, Gynostemma pentaphyllum extract, and ginsenoside Rb1; The auxiliary material is at least one of glucomannan, hydroxyethyl cellulose and pullulan.

2. The composition for reducing weight and removing dampness according to claim 1, wherein: The flavoring agent is selected from at least one of honey, sucrose, glucose, fructose, sucralose, aspartame, and erythritol.

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