Traditional Chinese medicine composition for treating slow growth with poor immunity and poor appetite as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition for treating slow growth with poor immunity and poor appetite as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. Comprising the following components in parts by weight: 6-24 parts of radix bupleuri, 6-12 parts of scutellaria baicalensis, 3-12 parts of rhizoma pinellinae praeparata, 5-12 parts of ginseng, 6-12 parts of ginger, 6-15 parts of jujube, 3-12 parts of liquorice, 6-12 parts of cassia twig, 6-12 parts of radix paeoniae alba, 6-15 parts of poria cocos, 6-15 parts of bighead atractylodes rhizome, 6-12 parts of pericarpium citri reticulatae, 6-15 parts of angelica sinensis, 3-10 parts of roasted radix aconiti lateralis preparata, 3-9 parts of fried fructus aurantii and 3-9 parts of mangnolia officinalis. According to the traditional Chinese medicine composition for treating slow growth with poor immunity and poor appetite as well as the preparation method and the application of the traditional Chinese medicine composition, the traditional Chinese medicine composition has a relatively good treatment effect on slow growth of children, immunity improvement and appetite enhancement, and compared with western medicine, the traditional Chinese medicine composition is low in treatment cost and small in side effect.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite, a preparation method thereof, and an application thereof. Background Art

[0002] In clinical practice, children with slow growth accompanied by poor immunity and poor appetite are relatively common. If timely intervention and treatment are not carried out, it may affect the final adult height of the children, and even lead to psychological disorders such as inferiority and loneliness. Although the western medicine growth hormone (GH) treatment can improve the height of children in the short term, it is difficult to correct the accompanying manifestations such as poor immunity and poor appetite, resulting in an unsatisfactory improvement in the final adult height.

[0003] Pediatric short stature is a common disease in pediatric endocrinology, which is defined as an individual with a height lower than the average height of the normal population by 2 standard deviations (-2 SD), or lower than the 3rd percentile (-1.88 SD) among individuals of the same race, gender, and age in a similar living environment. With the development of society, slow growth has increasingly attracted attention. In clinical practice, a considerable number of children seek medical treatment with slow growth as the main complaint, and are accompanied by symptoms such as poor immunity, repeated infections, and poor appetite. If timely intervention and treatment are not carried out, it may affect the final adult height of the children, and even lead to psychological disorders such as inferiority and loneliness.

[0004] Traditional Chinese medicine has currently been applied to treat children with relatively short stature who do not require GH treatment, as well as children with dwarfism who assist in GH treatment, and the curative effect is definite. Traditional Chinese medicine emphasizes treating the root cause of the disease. While treating slow growth, it can improve immunity, increase appetite, and take into account the overall pathogenesis of the disease to achieve the purpose of improving the final adult height. However, because traditional Chinese medicine treats diseases based on syndrome differentiation and treatment, there is a situation of inconsistent syndrome differentiation and medication among doctors for the treatment of most diseases with traditional Chinese medicine. For the treatment of slow growth, the views of different doctors vary, and the levels are also uneven, and the clinical curative effect is difficult to determine. In addition, the existing traditional Chinese medicine preparations cannot accurately grasp the core pathogenesis of the disease, and the long-term treatment effect is difficult to evaluate. Summary of the Invention

[0005] In view of this, the present invention provides a traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite, a preparation method thereof, and an application thereof, which has a better therapeutic effect on children's slow growth, improving immunity, and increasing appetite, and has lower cost and fewer side effects compared with western medicine treatment.

[0006] To achieve the above object, the present invention provides a traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite, comprising the following components in parts by weight: Bupleurum chinense 6 - 24 parts, Scutellaria baicalensis 6 - 12 parts, Pinellia ternata 3 - 12 parts, Ginseng 5 - 12 parts, Zingiber officinale 6 - 12 parts, Ziziphus jujuba 6 - 15 parts, Glycyrrhiza uralensis 3 - 12 parts, Cinnamomum cassia 6 - 12 parts, Paeonia lactiflora 6 - 12 parts, Poria cocos 6 - 15 parts, Atractylodes macrocephala 6 - 15 parts, Citrus reticulata Blanco 6 - 12 parts, Angelica sinensis 6 - 15 parts, Radix Aconiti Lateralis Preparata 3 - 10 parts, Fructus Aurantii Immaturus 3 - 9 parts, and Magnolia officinalis 3 - 9 parts.

[0007] Optionally, it comprises the following components in parts by weight: Bupleurum chinense 12 parts, Scutellaria baicalensis 6 parts, Pinellia ternata 6 parts, Ginseng 6 parts, Zingiber officinale 6 parts, Ziziphus jujuba 6 parts, Glycyrrhiza uralensis 3 parts, Cinnamomum cassia 6 parts, Paeonia lactiflora 6 parts, Poria cocos 10 parts, Atractylodes macrocephala 10 parts, Citrus reticulata Blanco 6 parts, Angelica sinensis 6 parts, Radix Aconiti Lateralis Preparata 5 parts, Fructus Aurantii Immaturus 3 parts, and Magnolia officinalis 3 parts.

[0008] To achieve the above object, the present invention also provides a preparation method of a traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite, comprising the following steps: Weigh Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Zingiber officinale, Ziziphus jujuba, Glycyrrhiza uralensis, Cinnamomum cassia, Paeonia lactiflora, Poria cocos, Atractylodes macrocephala, Citrus reticulata Blanco, Angelica sinensis, Radix Aconiti Lateralis Preparata, Fructus Aurantii Immaturus, and Magnolia officinalis according to parts by weight, soak them in water and decoct twice, combine the two water decoctions, filter, and collect the filtrate to obtain the traditional Chinese medicine composition.

[0009] To achieve the above object, the present invention also provides an application of a traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite in the preparation of traditional Chinese medicine preparations, and the raw materials of the traditional Chinese medicine preparations include the traditional Chinese medicine composition and excipients.

[0010] Optionally, the traditional Chinese medicine preparations are decoctions, oral liquids, tablets, capsules, and granules.

[0011] Optionally, the excipients are pharmaceutically acceptable excipients, diluents, stabilizers, preservatives, and flavoring agents.

[0012] Optionally, the preparation of the decoction comprises the following steps: Weigh Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Zingiber officinale, Ziziphus jujuba, Glycyrrhiza uralensis, Cinnamomum cassia, Paeonia lactiflora, Poria cocos, Atractylodes macrocephala, Citrus reticulata Blanco, Angelica sinensis, Radix Aconiti Lateralis Preparata, Fructus Aurantii Immaturus, and Magnolia officinalis according to parts by weight, add water 2 - 3 cm higher than the medicinal materials, soak for 20 - 30 minutes, bring to a boil over high heat and then change to low heat and decoct for 20 - 30 minutes, decoct each dose of medicine twice, squeeze the medicinal residues after the second decoction, combine the two decoction liquids, and filter to obtain the decoction.

[0013] Optionally, the preparation of the oral liquid comprises the following steps: Weigh Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Ginger, Jujube, Licorice Root, Cinnamon Twig, White Peony Root, Poria cocos, Atractylodes macrocephala, Tangerine Peel, Angelica sinensis, Prepared Aconite Root, Fructus Aurantii Immaturus, and Magnolia officinalis by weight parts, decoct twice with water, the water addition amounts are 7 - 9 times and 5 - 7 times the total weight of the medicinal materials respectively, soak for 0.4 - 0.6 hours, decoct for 1 - 2 hours and 0.5 - 1.5 hours respectively, combine the two water decoctions, filter, concentrate the filtrate to a medicinal liquid with a relative density of 1.05 - 1.08 g / ml at 60°C, then add 0.4 - 0.6% sodium benzoate, cool, filter, stir evenly, seal, and sterilize to obtain the oral liquid.

[0014] Optionally, the preparation of the oral liquid comprises the following steps: Weigh Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Ginger, Jujube, Licorice Root, Cinnamon Twig, White Peony Root, Poria cocos, Atractylodes macrocephala, Tangerine Peel, Angelica sinensis, Prepared Aconite Root, Fructus Aurantii Immaturus, and Magnolia officinalis by weight parts, decoct twice with water, the water addition amounts are 8 times and 6 times the total weight of the medicinal materials respectively, soak for 0.5 hours, decoct for 1.5 hours and 1 hour respectively, combine the two water decoctions, filter, concentrate the filtrate to a medicinal liquid with a relative density of 1.05 - 1.08 g / ml at 60°C, then add 0.5% sodium benzoate, cool, filter, stir evenly, seal, and sterilize to obtain the oral liquid.

[0015] Optionally, the preparation of the tablets comprises the following steps: Weigh Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Ginger, Jujube, Licorice Root, Cinnamon Twig, White Peony Root, Poria cocos, Atractylodes macrocephala, Tangerine Peel, Angelica sinensis, Prepared Aconite Root, Fructus Aurantii Immaturus, and Magnolia officinalis by weight parts, decoct twice with water, the water addition amounts are 7 - 9 times and 5 - 7 times the total weight of the medicinal materials respectively, soak for 0.4 - 0.6 hours, decoct for 1 - 2 hours and 0.5 - 1.5 hours respectively, combine the two water decoctions, filter, concentrate the filtrate to a thick medicinal paste with a relative density of 1.35 - 1.40 g / ml at 60°C, vacuum dry below 80°C, pulverize to 90 - 110 meshes, add 10% microcrystalline cellulose and 0.8 - 1.2% starch paste, make granules, dry at 80°C, add 2 - 4% magnesium stearate and 2 - 4% sodium carboxymethyl starch, mix evenly and press into tablets, coat with sugar coating to obtain the tablets.

[0016] Optionally, the preparation of the tablets comprises the following steps: weighing Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Zingiber officinale, Ziziphus jujuba, Glycyrrhiza uralensis, Cinnamomum cassia, Paeonia lactiflora, Poria cocos, Atractylodes macrocephala, Citrus reticulata, Angelica sinensis, Radix Aconiti Lateralis Praeparata, Fructus Aurantii Immaturus and Magnolia officinalis by weight parts, decocting twice with water, the water addition amounts being 8 times and 6 times the total weight of the medicinal materials respectively, soaking for 0.5 hour, decocting for 1.5 hours and 1 hour respectively, combining the two water decoctions, filtering, concentrating the filtrate to a thick ointment with a relative density of 1.35 - 1.40 g / ml at 60 °C, drying under vacuum below 80 °C, pulverizing to 100 meshes, adding 10% microcrystalline cellulose and 1% starch paste, granulating, drying at 80 °C, adding 3% magnesium stearate and 3% sodium carboxymethyl starch, mixing evenly and tabletting, coating with sugar coating to obtain the tablets.

[0017] Optionally, the preparation of the capsules comprises the following steps: weighing Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Zingiber officinale, Ziziphus jujuba, Glycyrrhiza uralensis, Cinnamomum cassia, Paeonia lactiflora, Poria cocos, Atractylodes macrocephala, Citrus reticulata, Angelica sinensis, Radix Aconiti Lateralis Praeparata, Fructus Aurantii Immaturus and Magnolia officinalis by weight parts, decocting twice with water, the water addition amounts being 7 - 9 times and 5 - 7 times the total weight of the medicinal materials respectively, soaking for 0.4 - 0.6 hour, decocting for 1 - 2 hours and 0.5 - 1.5 hours respectively, combining the two water decoctions, filtering, concentrating the filtrate to a thick ointment with a relative density of 1.35 - 1.40 g / ml at 60 °C, drying under vacuum below 80 °C, pulverizing to 30 - 50 meshes, adding 4 - 6% microcrystalline cellulose and 4 - 6% talc powder magnesium, mixing evenly and filling into capsules.

[0018] Optionally, the preparation of the capsules comprises the following steps: weighing Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Zingiber officinale, Ziziphus jujuba, Glycyrrhiza uralensis, Cinnamomum cassia, Paeonia lactiflora, Poria cocos, Atractylodes macrocephala, Citrus reticulata, Angelica sinensis, Radix Aconiti Lateralis Praeparata, Fructus Aurantii Immaturus and Magnolia officinalis by weight parts, decocting twice with water, the water addition amounts being 8 times and 6 times the total weight of the medicinal materials respectively, soaking for 0.5 hour, decocting for 1.5 hours and 1 hour respectively, combining the two water decoctions, filtering, concentrating the filtrate to a thick ointment with a relative density of 1.35 - 1.40 g / ml at 60 °C, drying under vacuum below 80 °C, pulverizing to 40 meshes, adding 5% microcrystalline cellulose and 5% talc powder magnesium, mixing evenly and filling into capsules.

[0019] Optionally, the preparation of the granules comprises the following steps: weighing Bupleurum chinense, Scutellaria baicalensis, Pinellia ternata, Ginseng, Zingiber officinale, Ziziphus jujuba, Glycyrrhiza uralensis, Cinnamomum cassia, Paeonia lactiflora, Poria cocos, Atractylodes macrocephala, Citrus reticulata, Angelica sinensis, Radix Aconiti Lateralis Praeparata, Fructus Aurantii Immaturus and Magnolia officinalis by weight parts, decocting twice with water, the water addition amounts being 7 - 9 times and 5 - 7 times the total weight of the medicinal materials respectively, soaking for 0.4 - 0.6 hour, decocting for 1 - 2 hours and 0.5 - 1.5 hours respectively, combining the two water decoctions, filtering, concentrating the filtrate to a thick ointment with a relative density of 1.35 - 1.40 g / ml at 60 °C, adding 18 - 22% dextrin and 3 - 4% stevioside, granulating through 10 - 12 meshes, drying, sizing and packaging to obtain the granules.

[0020] Optionally, the preparation of the granules comprises the following steps: Weigh Bupleuri Radix, Scutellariae Radix, Pinelliae Rhizoma Praeparatum, Ginseng Radix, Zingiberis Rhizoma Recens, Jujubae Fructus, Glycyrrhizae Radix Praeparata, Cinnamomi Ramulus, Paeoniae Radix Alba, Poria, Atractylodis Macrocephalae Rhizoma, Citri Reticulatae Pericarpium, Angelicae Sinensis Radix, Aconiti Lateralis Radix Praeparata, Aurantii Fructus Immaturus Semen Praeparatum, and Magnoliae Officinalis Cortex by parts by weight, decoct twice with water, the water addition amounts are 8 times and 6 times the total weight of the medicinal materials respectively, soak for 0.5 hour, decoct for 1.5 hours and 1 hour respectively, combine the two water decoctions, filter, concentrate the filtrate to a thick ointment with a relative density of 1.35 - 1.40 g / ml at 60°C, add 20% dextrin and 5% stevioside, granulate through a 12-mesh sieve, dry at 80°C, screen the granules, and package them to obtain the granules.

[0021] The above technical solution of the present invention has at least the following beneficial effects: 1. This formula is composed of the combined formula of Minor Bupleurum Decoction, Cinnamon Twig Decoction plus Aconite, Six Gentlemen Decoction, Four Counteractions Powder, etc. with modifications.

[0022] In the formula, Bupleuri Radix and Cinnamomi Ramulus are the monarch drugs, which are respectively modified from Minor Bupleurum Decoction and Cinnamon Twig Decoction plus Aconite in Treatise on Febrile Diseases. In the formula, Bupleuri Radix dredges and regulates the qi mechanism of Shaoyang, soothes the liver qi. Children's "constitution is of Shaoyang nature", and the qi of Shaoyang's growth is closely related to growth and development; Cinnamon Twig harmonizes nutrient qi and defensive qi, and defends the healthy qi. The combination of Bupleuri Radix and Cinnamon Twig has the effects of dredging and regulating Shaoyang, harmonizing nutrient qi and defensive qi, and strengthening the spleen and stomach.

[0023] Scutellariae Radix, Pinelliae Rhizoma Praeparatum, Ginseng Radix, Paeoniae Radix Alba, Poria, Atractylodis Macrocephalae Rhizoma, Citri Reticulatae Pericarpium, and Aconiti Lateralis Radix Praeparata are the ministerial drugs in total. In the formula, Scutellariae Radix clears and purges the pathogenic heat of Shaoyang, and combines with Bupleuri Radix to dredge and regulate the qi mechanism of Shaoyang; Paeoniae Radix Alba astringes yin and harmonizes nutrient qi, and when combined with Cinnamon Twig, it has the effect of harmonizing nutrient qi and defensive qi, and when combined with Bupleuri Radix, it has the effect of soothing the liver qi; Ginseng Radix supplements qi and tonifies the middle, strengthens the spleen and nourishes the stomach, Poria and Atractylodis Macrocephalae Rhizoma strengthen the spleen and eliminate dampness, promote the transportation and transformation of the spleen and stomach, Pinelliae Rhizoma Praeparatum, Citri Reticulatae Pericarpium harmonize the stomach and resolve phlegm. The combination of these five drugs has the effects of supplementing qi and strengthening the spleen, and harmonizing the stomach and resolving phlegm, which is a modification of Six Gentlemen Decoction; Aconiti Lateralis Radix Praeparata enters the spleen and kidney meridians, strengthens the spleen, warms the kidney and supports yang.

[0024] Angelicae Sinensis Radix, Aurantii Fructus Immaturus Semen Praeparatum, and Magnoliae Officinalis Cortex are the assistant drugs. In the formula, Angelicae Sinensis Radix nourishes blood and enters the liver meridian, and when combined with Paeoniae Radix Alba, it has the effect of nourishing blood and soothing the liver; Aurantii Fructus Immaturus Semen Praeparatum and Magnoliae Officinalis Cortex promote qi movement, assist the monarch drugs to dredge the qi mechanism, and regulate the triple energizer.

[0025] Zingiberis Rhizoma Recens, Jujubae Fructus, and Glycyrrhizae Radix Praeparata are the guiding drugs, which supplement qi and harmonize the stomach, and harmonize all the drugs.

[0026] The compatibility of all the drugs makes the liver qi smooth, the qi and blood exuberant, and the kidney qi sufficient, and together they achieve the effects of "strengthening the spleen and warming the kidney, dredging and regulating Shaoyang, and regulating the triple energizer".

[0027] 2. The present invention believes that the disease location of this disease is mainly in the liver, spleen and kidney, and the pathogenesis is "spleen deficiency and liver depression, kidney qi deficiency". The treatment is based on the method of "strengthening the spleen and warming the kidney, dredging and regulating Shaoyang, and regulating the triple energizer" to achieve the purposes of promoting growth, improving immunity, and increasing appetite.

[0028] 3. The present invention has a good therapeutic effect on children with slow growth, poor immunity and poor appetite. It can significantly improve children's slow growth, and has the effects of enhancing immunity, increasing appetite, improving adult final height, and has lower treatment costs and fewer side effects compared with Western medicine treatment. Detailed implementation manners To make the objectives, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are some, rather than all, embodiments of the present invention. Based on the described embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art belong to the scope of protection of the present invention.

[0029] Embodiment 1 A traditional Chinese medicine composition for treating slow growth, poor immunity and poor appetite is made from the following raw materials in parts by weight: 12 parts of Bupleurum chinense, 6 parts of Scutellaria baicalensis, 6 parts of Pinellia ternata, 6 parts of Ginseng, 6 parts of Zingiber officinale, 6 parts of Ziziphus jujuba, 3 parts of Glycyrrhiza uralensis, 6 parts of Cinnamomum cassia, 6 parts of Paeonia lactiflora, 10 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 6 parts of Citrus reticulata, 6 parts of Angelica sinensis, 5 parts of Radix Aconiti Lateralis Preparata, 3 parts of Fructus Aurantii Immaturus, 3 parts of Magnolia officinalis.

[0030] The above traditional Chinese medicine composition is prepared into a decoction, including the following steps: Take 12g of Bupleurum chinense, 6g of Scutellaria baicalensis, 6g of Pinellia ternata, 6g of Ginseng, 6g of Zingiber officinale, 6g of Ziziphus jujuba, 3g of Glycyrrhiza uralensis, 6g of Cinnamomum cassia, 6g of Paeonia lactiflora, 10g of Poria cocos, 10g of Atractylodes macrocephala, 6g of Citrus reticulata, 6g of Angelica sinensis, 5g of Radix Aconiti Lateralis Preparata, 3g of Fructus Aurantii Immaturus, 3g of Magnolia officinalis, add water to 2 cm above the medicinal materials, soak for 30 min, boil with strong fire and then change to slow fire and decoct for 30 min, decoct twice, squeeze the medicinal residues after the second decoction, combine the two decoction liquids, filter to obtain the decoction, and take the decoction in 2 times.

[0031] Embodiment 2 A traditional Chinese medicine composition for treating slow growth, poor immunity and poor appetite is made from the following raw materials in parts by weight: 24 parts of Bupleurum chinense, 12 parts of Scutellaria baicalensis, 12 parts of Pinellia ternata, 12 parts of Ginseng, 12 parts of Zingiber officinale, 15 parts of Ziziphus jujuba, 12 parts of Glycyrrhiza uralensis, 12 parts of Cinnamomum cassia, 12 parts of Paeonia lactiflora, 15 parts of Poria cocos, 15 parts of Atractylodes macrocephala, 12 parts of Citrus reticulata, 15 parts of Angelica sinensis, 10 parts of Radix Aconiti Lateralis Preparata, 9 parts of Fructus Aurantii Immaturus, 9 parts of Magnolia officinalis.

[0032] The above traditional Chinese medicine composition is prepared into granules, which includes the following steps: Take 24 g of Bupleuri Radix, 12 g of Scutellariae Radix, 12 g of Pinelliae Rhizoma Praeparatum, 12 g of Ginseng Radix, 12 g of Zingiberis Rhizoma Recens, 15 g of Jujubae Fructus, 12 g of Glycyrrhizae Radix, 12 g of Cinnamomi Ramulus, 12 g of Paeoniae Radix Alba, 15 g of Poria, 15 g of Atractylodis Macrocephalae Rhizoma, 12 g of Citri Reticulatae Pericarpium, 15 g of Angelicae Sinensis Radix, 10 g of Aconiti Lateralis Radix Praeparata, 9 g of Aurantii Fructus Immaturus Praeparata, 9 g of Magnoliae Officinalis Cortex, decoct twice with water, the water addition amounts are 8 times and 6 times the total weight of the medicinal materials respectively, soak for 0.5 hour, decoct for 1.5 hours and 1 hour respectively, combine the two water decoctions, filter, concentrate the filtrate to a thick ointment with a relative density of 1.35 - 1.40 g / ml at 60 °C, add 20% dextrin and 5% stevioside, pass through a 12-mesh sieve for granulation, dry at 80 °C, size the granules, and package them separately.

[0033] Example 3 A traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite is made from the following raw materials in parts by weight: 6 parts of Bupleuri Radix, 6 parts of Scutellariae Radix, 3 parts of Pinelliae Rhizoma Praeparatum, 5 parts of Ginseng Radix, 6 parts of Zingiberis Rhizoma Recens, 6 parts of Jujubae Fructus, 3 parts of Glycyrrhizae Radix, 6 parts of Cinnamomi Ramulus, 6 parts of Paeoniae Radix Alba, 6 parts of Poria, 6 parts of Atractylodis Macrocephalae Rhizoma, 6 parts of Citri Reticulatae Pericarpium, 6 parts of Angelicae Sinensis Radix, 3 parts of Aconiti Lateralis Radix Praeparata, 3 parts of Aurantii Fructus Immaturus Praeparata, 3 parts of Magnoliae Officinalis Cortex.

[0034] The above traditional Chinese medicine composition is prepared into oral liquid, which includes the following steps: Take 6 g of Bupleuri Radix, 6 g of Scutellariae Radix, 3 g of Pinelliae Rhizoma Praeparatum, 5 g of Ginseng Radix, 6 g of Zingiberis Rhizoma Recens, 6 g of Jujubae Fructus, 3 g of Glycyrrhizae Radix, 6 g of Cinnamomi Ramulus, 6 g of Paeoniae Radix Alba, 6 g of Poria, 6 g of Atractylodis Macrocephalae Rhizoma, 6 g of Citri Reticulatae Pericarpium, 6 g of Angelicae Sinensis Radix, 3 g of Aconiti Lateralis Radix Praeparata, 3 g of Aurantii Fructus Immaturus Praeparata, 3 g of Magnoliae Officinalis Cortex, add water equivalent to 8 times the total weight of the medicinal materials to soak for 0.5 h, decoct for 1.5 h, filter, collect the first decoction, add water equivalent to 6 times the total weight of the medicinal materials to the filter residue to decoct for 1 h, filter, collect the second decoction, combine the two decoctions, concentrate to a medicinal liquid with a relative density of 1.05 - 1.08 g / ml at 60 °C, then add 0.5% sodium benzoate by mass fraction, let it cool, filter, stir evenly, fill and seal, and sterilize to obtain the oral liquid.

[0035] Example 4 A traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite is made from the following raw materials in parts by weight: 18 parts of Bupleuri Radix, 10 parts of Scutellariae Radix, 10 parts of Pinelliae Rhizoma Praeparatum, 10 parts of Ginseng Radix, 9 parts of Zingiberis Rhizoma Recens, 9 parts of Jujubae Fructus, 6 parts of Glycyrrhizae Radix, 12 parts of Cinnamomi Ramulus, 12 parts of Paeoniae Radix Alba, 10 parts of Poria, 10 parts of Atractylodis Macrocephalae Rhizoma, 6 parts of Citri Reticulatae Pericarpium, 6 parts of Angelicae Sinensis Radix, 5 parts of Aconiti Lateralis Radix Praeparata, 6 parts of Aurantii Fructus Immaturus Praeparata, 6 parts of Magnoliae Officinalis Cortex.

[0036] The above traditional Chinese medicine composition is prepared into tablets, which includes the following steps: Take 18 g of Bupleuri Radix, 10 g of Scutellariae Radix, 10 g of Pinelliae Rhizoma Praeparatum, 10 g of Ginseng Radix, 9 g of Zingiberis Rhizoma Recens, 9 g of Jujubae Fructus, 6 g of Glycyrrhizae Radix, 12 g of Cinnamomi Ramulus, 12 g of Paeoniae Radix Alba, 10 g of Poria, 10 g of Atractylodis Macrocephalae Rhizoma, 6 g of Citri Reticulatae Pericarpium, 6 g of Angelicae Sinensis Radix, 5 g of Aconiti Lateralis Radix Praeparata, 6 g of Aurantii Fructus Immaturus Praeparata, 6 g of Magnoliae Officinalis Cortex, add water equivalent to 8 times the total weight of the medicinal materials and soak for 0.5 h, decoct for 1.5 h, filter, collect the first decoction liquid, add water equivalent to 6 times the total weight of the medicinal materials to the filter residue and decoct for 1 h, filter, collect the second decoction liquid, combine the two decoction liquids, concentrate to a thick ointment with a relative density of 1.35 - 1.40 g / ml at 60 °C, dry in vacuum below 80 °C, pulverize and pass through a 100-mesh sieve, add 10% microcrystalline cellulose and 1% starch paste by mass fraction, make granules, dry at 80 °C, add 3% magnesium stearate and 3% sodium carboxymethyl starch by mass fraction, mix evenly and press into tablets, coat with sugar coating, and thus obtain the tablets.

[0037] Example 5 A traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite is made from the following raw materials in parts by weight: 12 parts of Bupleuri Radix, 6 parts of Scutellariae Radix, 10 parts of Pinelliae Rhizoma Praeparatum, 10 parts of Ginseng Radix, 6 parts of Zingiberis Rhizoma Recens, 6 parts of Jujubae Fructus, 6 parts of Glycyrrhizae Radix, 6 parts of Cinnamomi Ramulus, 6 parts of Paeoniae Radix Alba, 15 parts of Poria, 15 parts of Atractylodis Macrocephalae Rhizoma, 12 parts of Citri Reticulatae Pericarpium, 12 parts of Angelicae Sinensis Radix, 10 parts of Aconiti Lateralis Radix Praeparata, 3 parts of Aurantii Fructus Immaturus Praeparata, 3 parts of Magnoliae Officinalis Cortex.

[0038] The above traditional Chinese medicine composition is prepared into a decoction, which includes the following steps: Take 12 g of Bupleuri Radix, 6 g of Scutellariae Radix, 10 g of Pinelliae Rhizoma Praeparatum, 10 g of Ginseng Radix, 6 g of Zingiberis Rhizoma Recens, 6 g of Jujubae Fructus, 6 g of Glycyrrhizae Radix, 6 g of Cinnamomi Ramulus, 6 g of Paeoniae Radix Alba, 15 g of Poria, 15 g of Atractylodis Macrocephalae Rhizoma, 12 g of Citri Reticulatae Pericarpium, 12 g of Angelicae Sinensis Radix, 10 g of Aconiti Lateralis Radix Praeparata, 3 g of Aurantii Fructus Immaturus Praeparata, 3 g of Magnoliae Officinalis Cortex, add water 3 cm higher than the surface of the medicinal materials, soak for 20 min, bring to a boil over high heat and then change to low heat and continue to decoct for 20 min, decoct twice, combine the two decoction liquids, filter and take in 3 doses.

[0039] Example 6 A traditional Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite is made from the following raw materials in parts by weight: 12 parts of Bupleuri Radix, 6 parts of Scutellariae Radix, 6 parts of Pinelliae Rhizoma Praeparatum, 6 parts of Ginseng Radix, 6 parts of Zingiberis Rhizoma Recens, 6 parts of Jujubae Fructus, 3 parts of Glycyrrhizae Radix, 6 parts of Cinnamomi Ramulus, 6 parts of Paeoniae Radix Alba, 10 parts of Poria, 10 parts of Atractylodis Macrocephalae Rhizoma, 6 parts of Citri Reticulatae Pericarpium, 6 parts of Angelicae Sinensis Radix, 5 parts of Aconiti Lateralis Radix Praeparata, 6 parts of Aurantii Fructus Immaturus Praeparata, 6 parts of Magnoliae Officinalis Cortex.

[0040] The above traditional Chinese medicine composition is prepared into a decoction, including the following steps: Take 12 g of Bupleuri Radix, 6 g of Scutellariae Radix, 6 g of Pinelliae Rhizoma Praeparatum, 6 g of Ginseng Radix, 6 g of Zingiberis Rhizoma Recens, 6 g of Jujubae Fructus, 3 g of Glycyrrhizae Radix, 6 g of Cinnamomi Ramulus, 6 g of Paeoniae Radix Alba, 10 g of Poria, 10 g of Atractylodis Macrocephalae Rhizoma, 6 g of Citri Reticulatae Pericarpium, 6 g of Angelicae Sinensis Radix, 5 g of Aconiti Lateralis Radix Praeparata, 6 g of Aurantii Fructus Immaturus, 6 g of Magnoliae Officinalis Cortex, add water to a height of 3 cm above the surface of the medicinal materials, soak for 20 min, bring to a boil over high heat and then continue to decoct over low heat for 20 min, decoct twice, combine the decoction liquids of the two times, filter and take in 3 doses.

[0041] Control Group 1 Select the existing Western medicine treatment method: orally take Lysine and Inositol and Vitamin B12 Oral Solution combined with lifestyle interventions (including diet, exercise, sleep, etc.). 12

[0042] Comparative experiment: 1. Case selection Select children with slow growth, poor immunity, and poor appetite treated from June 2021 to June 2023 for clinical observation, and randomly divide them into Treatment Groups 1 - 6 and Control Group 1. The average age of Treatment Groups 1 - 6 is (7.14 ± 1.00) years old, and the average age of Control Group 1 is (6.96 ± 1.07) years old. The gender and severity of the condition among the cases in each group are basically the same, with no significant differences and comparability.

[0043] 2. Administration method Treatment Groups 1 - 6: Use Examples 1 - 6 respectively, 1 dose per day, for a course of 6 months.

[0044] Control Group 1: Use Control Group 1, orally take Lysine and Inositol and Vitamin B12 Oral Solution, 5 - 10 mL each time, 2 times a day, and at the same time cooperate with lifestyle interventions (including diet, exercise, sleep, etc.).

[0045] 3. Inclusion criteria (1) Age ≥ 3 years old and ≤ 10 years old (female), or ≤ 12 years old (male); (2) Height is lower than the mean height of healthy children of the same age, gender, and race by 2 standard deviations (-2SD) or below the 3rd percentile; (3) Associated with symptoms such as poor immunity, repeated infections, and poor appetite; (4) The children and their parents give informed consent and sign the informed consent form.

[0046] 4. Exclusion criteria (1) Complicated with genetic metabolic diseases or accompanied by severe primary diseases such as heart, liver, kidney, endocrine, and blood systems; (2) Those who show the development of secondary sexual characteristics during the treatment process; (3) Those with poor compliance or those who are participating in other trials. ​

[0047] 5. Observation indicators Before and after treatment, monitor the changes in the height and weight of the children, the number of upper and lower respiratory tract infections, and count the proportion of children with less than 3 upper respiratory tract infections and less than 1 lower respiratory tract infection within half a year.

[0048] 6. Treatment results The treatment results are shown in Table 1 and Table 2; Table 1 shows the comparison of the growth of height and weight after treatment in Examples 1-6 and Comparative Example 1; Table 2 shows the comparison of the curative effects of respiratory tract infections after treatment in Examples 1-6 and Comparative Example 1.

[0049] Table 1 Growth of height and weight after treatment in Examples 1-6 and Comparative Example 1

[0050] Note: * indicates comparison with the comparative example, P < 0.05 Table 2 Comparison of the curative effects of respiratory tract infections after treatment in Examples 1-6 and Comparative Example 1

[0051] Combined with Table 1 and Table 2, it can be seen that the traditional Chinese medicine composition provided by this application has a better therapeutic effect on slow growth accompanied by poor immunity and poor appetite. At the same time, it is found in clinical use that the traditional Chinese medicine composition provided by this application can significantly improve the height and weight of children, reduce the occurrence of respiratory tract infections, and has great clinical application value.

[0052] Typical cases Case 1 The child Zhang XX, male, 7 years old, visited the doctor with the chief complaint of "anorexia, poor appetite accompanied by slow growth for 2 years". Symptoms: emaciated body, sallow complexion, fatigue, anorexia, poor appetite, excessive sweating, dry stools, and generally poor constitution, prone to colds. Physical examination: height: 115.1 cm, weight: 18.5 kg, no obvious abnormalities were found in the physical examination of the heart, lungs and abdomen, the tongue was light red, the tongue coating was white, and the pulse was stringy and thready. Laboratory tests: liver and kidney functions, blood cell analysis were normal, and the growth hormone stimulation test was normal. Diagnosis: Growth retardation (spleen deficiency and liver depression, kidney qi deficiency). The traditional Chinese medicine granules prepared according to the patent of this application were given, 14 doses, 1 dose per day, orally. After taking the medicine for 14 days, the appetite increased and the stool characteristics improved. Continue to take this prescription orally. After half a year of follow-up, the child's weight increased significantly, showing catch-up growth, normal stools, and rosy complexion.

[0053] Case 2 Patient Tian XX, male, 6 years and 3 months old, presented with the chief complaint of "slow growth and poor appetite for 3 years". Symptoms included slow growth, with an annual height increase of <5 cm, anorexia, a relatively thin build, a sallow complexion, a hasty temper, and frequent recurrent respiratory infections. Physical examination showed a height of 109.5 cm, a weight of 17.3 kg, pectus excavatum, and no obvious abnormalities in the abdominal examination. The tongue was pale, the tongue coating was white, and the pulse was string-like. Laboratory tests showed normal blood routine, liver, and kidney function, and normal growth hormone levels. Diagnosis: Growth retardation (spleen deficiency with liver depression, kidney qi deficiency). The patient was given the traditional Chinese medicine granules prepared according to the patent of this application, 1 dose per day, taken orally. After 1 week of taking the medicine, the appetite improved. After 1 month of taking the medicine, the complexion became rosy, and no obvious discomfort was reported. The patient continued to take the prescription. After 1 year of follow-up, the height increased by 8.7 cm, the diet was normal, and the physical constitution was enhanced.

[0054] Case 3 Patient Wang XX, female, 5.5 years old, presented with the chief complaint of "slow growth and recurrent respiratory infections for 2 years". Symptoms included slow growth. After starting kindergarten 2 years ago, the patient had recurrent respiratory infections and a poor constitution, accompanied by reduced appetite and dry stools, with a relatively thin build. Physical examination showed a height of 105 cm and a weight of 15 kg. The anterior and posterior hairline were normal, no webbed neck, shield chest, or cubitus valgus were seen, the nipple distance was normal, and no obvious abnormalities were found in the cardiopulmonary examination. The abdomen was slightly distended, without tenderness or rebound tenderness. The tongue was red, the tongue coating was white, and the pulse was string-like and thready. Diagnosis: Growth retardation (spleen deficiency with liver depression, kidney qi deficiency). The patient was given the traditional Chinese medicine granules prepared according to the patent of this application, 1 dose per day, taken orally. After 1 week of taking the medicine, the diet improved and the stools were normal. After 1 month of taking the medicine, no respiratory infections occurred, and the food intake increased significantly. The patient continued to take the prescription for 6 months, and the height and weight increased significantly compared to before, and the physical constitution improved.

[0055] Case 4 Patient Zheng XX, female, 8 years old, presented with the chief complaint of "slow growth for 3 years". Symptoms included slow growth, with an annual height increase of <5 cm, a sallow complexion, a relatively thin build, less food intake, cold hands and feet easily, and a poor constitution. Physical examination showed a height of 118 cm and a weight of 18.6 kg. The anterior and posterior hairline were normal, no webbed neck, shield chest, cubitus valgus, or other Turner's signs were seen, and no obvious abnormalities were found in the cardiopulmonary and abdominal examinations. The tongue was pale, the tongue coating was thin white with tooth marks, and the pulse was thready. Laboratory tests showed normal blood routine, liver, and kidney function, and normal growth hormone and cortisol levels. Diagnosis: Growth retardation (spleen deficiency with liver depression, kidney qi deficiency). The patient was given the traditional Chinese medicine granules prepared according to the patent of this application, 14 doses, 1 dose per day, taken orally. After 14 days of taking the medicine, the diet improved, the hands and feet became warm, and the mental state improved. The patient continued to take the prescription orally. After 6 months of follow-up, the patient's height was 122.6 cm, weight was 20.5 kg, both increased significantly, the complexion was rosy, and the patient was not prone to catching cold, and no other discomfort symptoms were reported.

[0056] Combined with the above cases, the technical solution provided by this application strengthens the root and cultivates the yuan, realizes the enhancement of children's immunity, and has a significant effect on treating slow growth.

[0057] The above are the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite, characterized in that: The invention comprises the following components in parts by weight: 6-24 parts of bupleurum, 6-12 parts of scutellaria, 3-12 parts of pinellia, 5-12 parts of ginseng, 6-12 parts of ginger, 6-15 parts of jujube, 3-12 parts of licorice, 6-12 parts of cinnamon twig, 6-12 parts of white peony root, 6-15 parts of poria, 6-15 parts of atractylodes, 6-12 parts of tangerine peel, 6-15 parts of angelica, 3-10 parts of roasted aconite, 3-9 parts of stir-fried fructus aurantii and 3-9 parts of magnolia bark.

2. The Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 12 parts of bupleurum, 6 parts of scutellaria, 6 parts of pinellia, 6 parts of ginseng, 6 parts of ginger, 6 parts of jujube, 3 parts of licorice, 6 parts of cinnamon twig, 6 parts of white peony root, 10 parts of poria, 10 parts of atractylodes, 6 parts of tangerine peel, 6 parts of angelica, 5 parts of roasted aconite, 3 parts of stir-fried fructus aurantii and 3 parts of magnolia bark.

3. The method for preparing the Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to any one of claims 1 to 2, characterized in that: The method comprises the following steps: weighing bupleurum, scutellaria, pinellia, ginseng, ginger, jujube, liquorice, cassia twig, white peony root, poria, atractylodes, tangerine peel, angelica, roasted aconite, stir-fried fructus aurantii and magnolia bark according to weight proportions, soaking in water and then decocting twice, combining the two decoctions, filtering and collecting the filtrate to obtain the traditional Chinese medicine composition.

4. Use of the Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to any one of claims 1 to 2 in the preparation of Chinese medicine preparations, characterized in that: The raw materials of the traditional Chinese medicine preparation include the traditional Chinese medicine composition and auxiliary materials.

5. Use of the Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to claim 4 in the preparation of Chinese medicine preparations, characterized in that: The Chinese medicine preparations are decoctions, oral liquids, tablets, capsules and granules.

6. Use of the Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to claim 4 in the preparation of Chinese medicine preparations, characterized in that: The auxiliary materials are medically acceptable excipients, diluents, stabilizers, preservatives and flavoring agents.

7. Use of the Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to claim 4 in the preparation of Chinese medicine preparations, characterized in that: The preparation of the decoction comprises the following steps: Weigh bupleurum, scutellaria, pinellia, ginseng, ginger, jujube, licorice, cinnamon twig, white peony root, poria, atractylodes, tangerine peel, angelica, roasted aconite, stir-fried fructus aurantii and magnolia bark by weight, add water to the surface of the slices by 2-3 cm, soak for 20-30 minutes, boil over high heat, then simmer over low heat for 20-30 minutes. Decoction each dose twice, squeeze out the residue after the second decoction, combine the two decoctions, and filter to obtain a decoction.

8. Use of the Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to claim 4 in the preparation of Chinese medicine preparations, characterized in that: The preparation of the oral liquid comprises the following steps: Weigh bupleurum, scutellaria, pinellia, ginseng, ginger, jujube, liquorice, cassia twig, white peony root, poria, atractylodes, tangerine peel, angelica, roasted aconite, stir-fried fructus aurantii and magnolia officinalis according to weight, add water and boil twice, the amount of water added is 7-9 times and 5-7 times the total weight of the medicinal materials respectively, soak for 0.4-0.6 hour, boil for 1-2 hour and 0.5-1.5 hour respectively, combine the two decoctions, filter, concentrate the filtrate to a medicinal solution with a relative density of 1.05-1.08 g / ml at 60°C, add 0.4-0.6% sodium benzoate, cool, filter, stir well, fill and sterilize to obtain an oral solution.

9. Use of the Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to claim 4 in the preparation of Chinese medicine preparations, characterized in that: The preparation of the tablet comprises the following steps: Weigh bupleurum, scutellaria, pinellia, ginseng, ginger, jujube, liquorice, cassia twig, white peony root, poria, atractylodes, tangerine peel, angelica, roasted aconite, stir-fried fructus aurantii and magnolia officinalis according to weight, add water and boil twice, the amount of water added is 7-9 times and 5-7 times the total weight of the medicinal materials respectively, soak for 0.4-0.6 hour, boil for 1-2 hour and 0.5-1.5 hour respectively, combine the two decoctions, filter, concentrate the filtrate to a thick ointment with a relative density of 1.35-1.40 g / ml at 60°C, vacuum dry at below 80°C, crush to 90-110 mesh, add 10% microcrystalline cellulose and 0.8-1.2% starch slurry, make granules, dry at 80°C, add 2-4% magnesium stearate and 2-4% sodium carboxymethyl starch, mix well, press into tablets, coat with sugar to obtain tablets.

10. Use of the Chinese medicine composition for treating slow growth accompanied by poor immunity and poor appetite according to claim 4 in the preparation of Chinese medicine preparations, characterized in that: The preparation of the capsule comprises the following steps: weighing bupleurum, scutellaria, pinellia, ginseng, ginger, jujube, liquorice, cassia twig, white peony root, poria, atractylodes, tangerine peel, angelica, roasted aconite, stir-fried fructus aurantii and magnolia officinalis according to weight, decocting twice with water, wherein the amount of water added is 7-9 times and 5-7 times of the total weight of the medicinal materials respectively, soaking for 0.4-0.6 hours, decocting for 1-2 hours and 0.5-1.5 hours respectively, combining the two decoctions, filtering, concentrating the filtrate to a thick ointment with a relative density of 1.35-1.40 g / ml at 60° C., vacuum drying at below 80° C., crushing to 30-50 mesh, adding 4-6% microcrystalline cellulose and 4-6% talc magnesium, mixing evenly, and filling into capsules.

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