Antibacterial medical band-aid and preparation method thereof

Abstract

The invention relates to the technical field of medical equipment, and discloses an antibacterial medical band-aid and a preparation method thereof.The medical band-aid comprises a base band and a dressing layer arranged in the middle of the base band; wherein the dressing layer is prepared by taking polyvinyl alcohol as a main raw material and an aerogel additive as an auxiliary material through electrostatic spinning, the aerogel additive has a rich pore structure, and the existence of the pore structure can be beneficial to improving the water absorption and storage effects of the dressing layer, so that percolate at a wound can be effectively absorbed, and the wound healing effect is improved. A continuous humid environment at the wound is prevented from forming a hotbed for bacterium breeding. Besides, the aerogel additive structure contains a large number of sorbate structures, conjugated double bonds in the structures can be combined with sulfydryl of microbial enzymes, enzyme system structures are destroyed, the enzymes are inactivated, and finally microbial reproduction is inhibited, so that the dressing layer is endowed with excellent antibacterial performance, and the problem of bacterial infection at the wound is effectively avoided.

Description

Technical Field

[0001] The invention relates to the technical field of medical equipment, and in particular to an antibacterial medical band-aid and a preparation method thereof. Background Art

[0002] As a convenient wound care product, medical bandages have been widely used in home medical and emergency situations since their introduction. They are usually composed of a base band and an inner dressing layer, each of which has a specific function and works together to promote wound healing. With the advancement of material science, the materials of medical bandages are also constantly being updated.

[0003] Polyvinyl alcohol is a known water-soluble, non-toxic, non-irritating, odorless polymer that is harmless to the human body and has excellent biocompatibility. This makes it an ideal medical material that can create a safe and harmless healing environment at the wound. Moreover, compared with ordinary pure cotton gauze, polyvinyl alcohol fabric has stronger water absorption and can more effectively absorb blood and tissue fluid exuded from the wound, keep the wound dry, help reduce the risk of infection and promote healing. In addition, polyvinyl alcohol fabric has the characteristics of not absorbing oil exudate, which can effectively prevent adhesion to the wound and wound tissue, reduce the pain during dressing changes, and shorten the wound healing time. In addition, polyvinyl alcohol also has good plasticity and can be easily processed into various shapes and sizes to meet the needs of different wounds. Therefore, the use of polyvinyl alcohol as a dressing layer material for medical band-aids has become a research hotspot.

[0004] However, polyvinyl alcohol itself has poor antibacterial properties and cannot effectively kill bacteria in wounds, so it cannot completely avoid bacterial infection in wounds. This is also a major obstacle to the application of polyvinyl alcohol in the field of medical devices. Conventional small molecule antibacterial agents are easy to precipitate, and antibacterial agents such as silver are heavy metals themselves, which are easy to cause environmental pollution after abandonment. Therefore, other methods are needed to modify polyvinyl alcohol for antibacterial properties. Summary of the invention

[0005] 1. Technical issues to be solved

[0006] In view of the deficiencies in the prior art, the present invention provides an antibacterial medical bandage and a preparation method thereof.

[0007] (II) Technical solution

[0008] A method for preparing an antibacterial medical bandage, the medical bandage comprising a base band and a dressing layer arranged in the middle of the base band;

[0009] The dressing layer is made of the following raw materials measured in parts by weight:

[0010] 72-78 parts of polyvinyl alcohol, 3-6.5 parts of aerogel additive, 260-300 parts of deionized water;

[0011] The dressing layer is prepared by the following method:

[0012] The first step is to weigh each raw material according to its weight and add it into a stirring kettle, control the temperature in the kettle to 90±5°C, adjust the speed to 300-500r / min, and mechanically stir and mix for 1-2h to form an electrospinning solution;

[0013] The second step is to inject the electrospinning solution into the electrospinning machine, make the grey cloth through electrospinning, and then cut the grey cloth;

[0014] The preparation method of the adhesive bandage is as follows:

[0015] Stick the block dressing layer to the middle of the base tape, press it, and then stick the release film on the adhesive surface of the base tape.

[0016] As a further solution of the present invention, the specific preparation method of the aerogel additive is as follows:

[0017] Step S1, adding gellan gum to an ethanol aqueous solution with a volume fraction of 60-70%, raising the temperature to 50-60°C, mechanically stirring and mixing, then adding a sorbic acid derivative cross-linking agent to the formed mixed solution, and adding a phase transfer catalyst for catalysis, then further raising the temperature to 70-80°C, keeping the temperature and stirring for 12-24 hours, stopping heating, cooling and discharging the material to form a gellan gum cross-linked modified material;

[0018] Step S2, placing the cross-linked modified gellan gum in a mold, drying it at 80-90° C. for 12-16 hours, placing it in a freeze dryer, controlling the temperature to -50° C., freeze drying it for 24-48 hours, and then taking it out to obtain an aerogel additive.

[0019] As a further embodiment of the present invention, in step S1, the preparation method of the sorbic acid-derived cross-linking agent is as follows:

[0020] Sorbic acid is added to tetrahydrofuran, and after mechanical stirring and mixing, a condensation agent and an accelerator are added. After the addition is completed, the mixture is stirred and mixed for 30-60 minutes. Then, 3-[bis(glycidyloxymethyl)methoxy]-1,2-propanediol is added. After the addition is completed, nitrogen is introduced for protection. After stirring and mixing at room temperature for 6-9 hours, the solvent is evaporated and removed. After purification treatment, a sorbic acid-derived cross-linking agent can be obtained.

[0021] As a further solution of the present invention, the molar ratio of sorbic acid to 3-[bis(glycidoxymethyl)methoxy]-1,2-propanediol is 1-2:1.

[0022] As a further solution of the present invention, the condensing agent is at least one of dicyclohexylcarbodiimide or 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide.

[0023] As a further solution of the present invention, the accelerator is at least one of 4-dimethylaminopyridine or N-hydroxysuccinimide.

[0024] As a further solution of the present invention, the mass ratio of the condensing agent to the accelerator is 1:0.2-0.3.

[0025] As a further solution of the present invention, in step S1, the phase transfer catalyst is any one of tetrabutylammonium bromide, tetrabutylammonium chloride, tetramethylammonium bromide or tetrabutylammonium hydrogensulfate.

[0026] In the above technical solution, first, the active carboxyl substituent in the structure of sorbic acid is activated by using a condensing agent and an accelerator, and then 3-[bis(glycidoxymethyl)methoxy]-1,2-propanediol is added as a reactant. Through the condensation reaction with the active hydroxyl substituent in its structure, a sorbic acid-derived crosslinking agent containing two equivalents of epoxy substituents in the structure can be prepared.

[0027] Then, using gellan gum as the gel material, under the catalytic action of the phase transfer catalyst, the epoxy substituents in the structure of the sorbic acid-derived crosslinking agent can carry out continuous ring-opening addition reactions with gellan gum to achieve crosslinking modification of gellan gum, obtaining a gellan gum crosslinked modified material. Then, through the freeze-drying method, it is made into an aerogel material with a large number of pore structures, that is, the aerogel additive.

[0028] As a further solution of the present invention, in the second step, the spinning voltage during electrospinning is 10-20 kV, the injection speed is 5-15 mL / h, and the receiving distance is 10-15 cm.

[0029] An antibacterial medical wound dressing is prepared by using the above preparation method.

[0030] (III) Beneficial technical effects

[0031] The present invention prepares an aerogel additive, blends it with polyvinyl alcohol, and then obtains the dressing layer of the band-aid through an electrospinning process. First, compared with directly making gellan gum into an aerogel, using a sorbic acid-derived crosslinking agent to crosslink gellan gum can greatly improve the pore richness of the gellan gum aerogel. The existence of the pore structure is beneficial to improving the water absorption and water storage effects of the dressing layer, and thus can effectively absorb the exudate at the wound, avoiding the continuous humid environment at the wound from forming a hotbed for bacterial growth. In addition, the aerogel additive structure contains a large number of sorbate structures. The conjugated double bonds in this structure can bind to the sulfhydryl groups of microbial enzymes, destroy the enzyme system structure, inactivate the enzymes, and ultimately inhibit the reproduction of microorganisms, thereby endowing the dressing layer with excellent antibacterial properties and effectively avoiding the problem of bacterial infection at the wound. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for describing the embodiments will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0033] Figure 1 Scanning electron microscope images of the aerogel additive and the aerogel material. DETAILED DESCRIPTION OF THE INVENTION

[0034] To facilitate the understanding of the present invention, the present invention will be described more comprehensively below. Preferred embodiments of the present invention are given below. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0035] Preparation Example 1

[0036] Preparation of the aerogel additive:

[0037] Step S1: Add 1.2 g of sorbic acid to tetrahydrofuran, mechanically stir and mix evenly, then add 0.1 g of dicyclohexylcarbodiimide and 0.03 g of 4-dimethylaminopyridine. After adding, stir and mix for 40 min, then add 1.5 g of 3-[bis(glycidoxymethyl)methoxy]-1,2-propanediol. After adding, introduce nitrogen for protection, continue to stir and mix at room temperature for 8 h, then evaporate to remove the solvent, and through a purification treatment process, the sorbic acid-derived crosslinking agent can be obtained;

[0038] Step S2: Add 2.4 g of gellan gum into an ethanol aqueous solution with a volume fraction of 70%. After adding, raise the temperature to 60°C. After mechanically stirring and mixing evenly, add 0.5 g of sorbic acid derivative cross-linking agent into the formed mixed solution, and simultaneously add 0.1 g of tetrabutylammonium bromide for catalysis. Then further raise the temperature to 75°C, keep stirring and heat-insulating for 18 h, stop heating, cool down and discharge to form a gellan gum cross-linked modified material;

[0039] Step S3: Place the gellan gum cross-linked modified material in a mold, dry it at 90°C for 16 h, then place it in a freeze dryer, control the temperature at -50°C, and after freeze-drying for 48 h, take it out to obtain an aerogel additive.

[0040] Example 1

[0041] Preparation of the dressing layer:

[0042] First step: According to the weight parts, add 72 parts of polyvinyl alcohol, 3 parts of aerogel additive and 260 parts of deionized water into a stirring kettle, control the temperature in the kettle at 90°C, and at the same time adjust the rotation speed to 300 r / min, and mechanically stir and mix for 2 h to form an electrospinning solution;

[0043] Second step: Inject the electrospinning solution into an electrospinning machine, control the spinning voltage at 10 kV, the injection speed at 5 mL / h, and the receiving distance at 10 cm. After electrospinning to make a green cloth, and then cut the green cloth to obtain the dressing layer.

[0044] The preparation method of the aerogel additive is shown in Preparation Example 1, and the same applies hereinafter.

[0045] Example 2

[0046] Preparation of the dressing layer:

[0047] First step: According to the weight parts, add 74 parts of polyvinyl alcohol, 6 parts of aerogel additive and 280 parts of deionized water into a stirring kettle, control the temperature in the kettle at 90°C, and at the same time adjust the rotation speed to 400 r / min, and mechanically stir and mix for 2 h to form an electrospinning solution;

[0048] Second step: Inject the electrospinning solution into an electrospinning machine, control the spinning voltage at 15 kV, the injection speed at 10 mL / h, and the receiving distance at 12 cm. After electrospinning to make a green cloth, and then cut the green cloth to obtain the dressing layer.

[0049] Example 3

[0050] Preparation of the dressing layer:

[0051] Step 1: Add 78 parts by weight of polyvinyl alcohol, 6.5 parts of aerogel additive, and 300 parts of deionized water into a stirring kettle. Control the temperature in the kettle at 90°C, and at the same time adjust the rotation speed to 500 r / min. Mechanically stir and mix for 1 h to form an electrospinning solution.

[0052] Step 2: Inject the electrospinning solution into an electrospinning machine. Control the spinning voltage at 20 kV, the injection speed at 15 mL / h, and the receiving distance at 15 cm. Produce a green fabric through electrospinning, and then cut the green fabric to obtain the dressing layer.

[0053] Comparative Example 1

[0054] Preparation of the dressing layer:

[0055] Step 1: Add 74 parts by weight of polyvinyl alcohol, 6 parts of aerogel material, and 280 parts of deionized water into a stirring kettle. Control the temperature in the kettle at 90°C, and at the same time adjust the rotation speed to 400 r / min. Mechanically stir and mix for 2 h to form an electrospinning solution.

[0056] Step 2: Inject the electrospinning solution into an electrospinning machine. Control the spinning voltage at 15 kV, the injection speed at 10 mL / h, and the receiving distance at 12 cm. Produce a green fabric through electrospinning, and then cut the green fabric to obtain the dressing layer.

[0057] The preparation method of the aerogel material is as follows:

[0058] Add gellan gum into purified water with a volume fraction. After adding, raise the temperature to 90°C. Mechanically stir and mix evenly, then stop heating. After it cools naturally, place it in a mold and dry it at 90°C for 16 h. Then place it in a freeze dryer, control the temperature at -50°C, and perform freeze-drying treatment for 48 h. After taking it out, the aerogel material can be obtained.

[0059] Figure 1 Figures (1) and (2) are the scanning electron microscope images of the aerogel additive and the aerogel material respectively. It can be seen from the figures that the pore structure of the aerogel additive is significantly more abundant and more evenly distributed.

[0060] Comparative Example 2

[0061] Preparation of the dressing layer:

[0062] Step 1: Add 74 parts by weight of polyvinyl alcohol and 280 parts of deionized water into a stirring kettle. Control the temperature in the kettle at 90°C, and at the same time adjust the rotation speed to 400 r / min. Mechanically stir and mix for 2 h to form an electrospinning solution.

[0063] Step 2: Inject the electrospinning solution into an electrospinning machine, control the spinning voltage at 15 kV, the injection speed at 10 mL / h, and the receiving distance at 12 cm. Produce a green fabric through electrospinning, and then cut the green fabric to obtain the dressing layer.

[0064] Test examples

[0065] Conduct various tests on the dressing layers in the examples and comparative examples, and record the results in Table 1:

[0066] Table 1 - Test results

[0067] Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Bacteriostatic rate (%) 99.5 99.6 99.5 61.1 61.0 Water absorption ratio (g / g) 264.8 265.3 265.1 238.1 184.9

[0068] The test method for the antibacterial rate is as follows: Make the fibers in the examples and comparative examples into test samples that meet the specifications, and conduct the antibacterial rate test with reference to Standard GB / T 20944.3 - 2008;

[0069] The test method for the water absorption ratio is as follows: Cut the fibers in the examples and comparative examples into 2 - cm samples, weigh them, and record the weight as M 1 , then immerse the samples in water, take them out after 4 h, wait until no more water drops out from their surfaces, weigh them again, and record the weight as M 2 , calculate the water absorption ratio of the samples, and the calculation formula is (M 2 - M 1 ) / M 1 .

[0070] Analysis of the test results shows that using the aerogel additive in Preparation Example 1 of the present invention as an additive can endow the dressing layer with good antibacterial properties and a relatively high water absorption ratio, showing excellent water absorption effect. After replacing the aerogel additive with an aerogel material made of conventional uncrosslinked gellan gum, on the one hand, the specific conjugated structure of sorbic acid is lost, resulting in a significant decline in antibacterial properties; on the other hand, the porosity of the uncrosslinked aerogel material is relatively low, and the water absorption effect also decreases to a certain extent.

[0071] In the description of this specification, the description with reference to terms such as "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials, or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above - mentioned terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described can be combined in a suitable manner in any one or more embodiments or examples. In addition, without contradiction, those skilled in the art can combine and combine the different embodiments or examples described in this specification and the features of different embodiments or examples.

[0072] Based on the inspiration of the ideal embodiments of the present invention, through the above description, relevant personnel can completely make various changes and modifications without departing from the technical idea of this invention. The technical scope of this invention is not limited to the content in the specification, and the technical scope must be determined according to the scope of the claims.

Claims

1. A method for preparing an antibacterial medical bandage, characterized in that: The medical bandage comprises a base band and a dressing layer arranged in the middle of the base band; The dressing layer is made of the following raw materials measured in parts by weight: 72-78 parts of polyvinyl alcohol, 3-6.5 parts of aerogel additive, 260-300 parts of deionized water; The dressing layer is prepared by the following method: The first step is to weigh each raw material according to its weight and add it into a stirring kettle, control the temperature in the kettle to 90±5°C, adjust the speed to 300-500r / min, and mechanically stir and mix for 1-2h to form an electrospinning solution; The second step is to inject the electrospinning solution into the electrospinning machine, make the grey cloth through electrospinning, and then cut the grey cloth; The preparation method of the adhesive bandage is as follows: Stick the block dressing layer to the middle of the base tape, press it, and then stick the release film on the adhesive surface of the base tape.

2. The method for preparing an antibacterial medical bandage according to claim 1, characterized in that: The specific preparation method of the aerogel additive is as follows: Step S1, adding gellan gum to an ethanol aqueous solution with a volume fraction of 60-70%, raising the temperature to 50-60°C, mechanically stirring and mixing, then adding a sorbic acid derivative cross-linking agent to the formed mixed solution, and adding a phase transfer catalyst for catalysis, then further raising the temperature to 70-80°C, keeping the temperature and stirring for 12-24 hours, stopping heating, cooling and discharging the material to form a gellan gum cross-linked modified material; Step S2, placing the cross-linked modified gellan gum in a mold, drying it at 80-90° C. for 12-16 hours, placing it in a freeze dryer, controlling the temperature to -50° C., freeze drying it for 24-48 hours, and then taking it out to obtain an aerogel additive.

3. The method for preparing an antibacterial medical bandage according to claim 2, characterized in that: In step S1, the preparation method of the sorbic acid-derived cross-linking agent is as follows: Sorbic acid is added to tetrahydrofuran, and after mechanical stirring and mixing, a condensation agent and an accelerator are added. After the addition is completed, the mixture is stirred and mixed for 30-60 minutes. Then, 3-[bis(glycidyloxymethyl)methoxy]-1,2-propanediol is added. After the addition is completed, nitrogen is introduced for protection. After stirring and mixing at room temperature for 6-9 hours, the solvent is evaporated and removed. After purification treatment, a sorbic acid-derived cross-linking agent can be obtained.

4. The method for preparing an antibacterial medical bandage according to claim 3, characterized in that: The molar ratio of the sorbic acid to 3-[bis(glycidyloxymethyl)methoxy]-1,2-propanediol is 1-2:

1.

5. The method for preparing an antibacterial medical bandage according to claim 3, characterized in that: The condensing agent is at least one of dicyclohexylcarbodiimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide.

6. The method for preparing an antibacterial medical bandage according to claim 3, characterized in that: The accelerator is at least one of 4-dimethylaminopyridine and N-hydroxysuccinimide.

7. The method for preparing an antibacterial medical bandage according to claim 3, characterized in that: The mass ratio of the condensing agent to the accelerator is 1:0.2-0.

3.

8. The method for preparing an antibacterial medical bandage according to claim 2, characterized in that: In step S1, the phase transfer catalyst is any one of tetrabutylammonium bromide, tetrabutylammonium chloride, tetramethylammonium bromide or tetrabutylammonium hydrogen sulfate.

9. The method for preparing an antibacterial medical bandage according to claim 1, characterized in that: In the second step, the spinning voltage during the electrospinning is 10-20 kV, the injection speed is 5-15 mL / h, and the receiving distance is 10-15 cm.

10. An antibacterial medical bandage, characterized in that: The method is prepared according to any one of claims 1 to 9.

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