Liquid chromatography-mass spectrometry detection method for benzophenone ultraviolet absorbent in packaging material

Abstract

The invention relates to the technical field of ultraviolet absorbent detection, in particular to a liquid chromatography-mass spectrometry detection method for a benzophenone ultraviolet absorbent in a packaging material, which comprises the following steps: S1, preparing a standard solution and a to-be-detected sample solution, weighing a sample, putting the sample into a container, adding methanol, infiltrating, and then extracting and filtering by using ultrasonic waves to obtain the to-be-detected sample solution; s2, respectively taking the to-be-detected sample solution and the standard solution, analyzing the to-be-detected sample solution and the standard solution by liquid chromatography-mass spectrometry, and detecting the concentration of the ultraviolet absorbent in the to-be-detected sample solution; a chromatographic column in the liquid chromatography-mass spectrometry is a C18 stationary phase chromatographic column, a mobile phase A is 0.1% formic acid water, and a mobile phase B is methanol; gradient elution is adopted, and the change range of the volume of the mobile phase B along with time is 0-1.0 min, 60%-90% of the volume of the mobile phase B; when the time is 1.0 min to 3.0 min, 90% to 95% of B is used; when the time is 3.0 min to 8.0 min, 95% of B is reached; when the time is 8.1 min to 13.0 min, 60% of B is reached. According to the method, the eight benzophenone ultraviolet absorbents are rapidly and quantitatively determined by using a liquid chromatography-mass spectrometry method, the detection accuracy and precision are relatively high, and the detection limit is relatively low.

Description

Technical Field

[0001] The present invention relates to the technical field of ultraviolet absorber detection, and specifically provides a liquid chromatography-mass spectrometry (LC-MS) detection method for benzophenone ultraviolet absorbers in packaging materials. Background Art

[0002] In the industrial manufacturing process of degradable plastic packaging products, in order to meet the physical and chemical property requirements of products in some aspects, certain processing aids are often added. In addition to the well-known plasticizers among these additives, antioxidants and ultraviolet absorbers also play important roles. Among them, ultraviolet absorbers can effectively absorb light in the ultraviolet band (light with a wavelength of 290 - 410 nm), thereby effectively slowing down the oxidative decomposition of degradable plastic products under light conditions. Antioxidants can effectively capture free radicals generated by degradable plastics under the external actions of oxygen, light, heat, etc. during processing and use, and timely and effectively block the fracture of plastic molecules. The use of these two types of substances can effectively improve the physical properties of degradable plastic packaging products and extend the shelf life of degradable plastic products.

[0003] Therefore, these two types of substances have extensive applications. For example, ultraviolet absorbers are also used in cigarette packaging materials. However, in the production process, in order to pursue the physical properties of products, there is often an excessive addition situation. Excessive ultraviolet absorbers may migrate into cigarettes and then be inhaled or ingested by smokers, potentially affecting health; if the packaging material directly contacts the skin, excessive ultraviolet absorbers may cause allergic reactions or other skin problems; and excessive ultraviolet absorbers may affect the biodegradability of packaging materials, increasing the risk of environmental pollution. Some ultraviolet absorbers may also affect the recycling and reuse of packaging materials, increasing the treatment cost and environmental burden.

[0004] However, currently, most methods can detect fewer types of ultraviolet absorbers, lack methods for simultaneously detecting multiple ultraviolet absorbers, and have low precision. Summary of the Invention

[0005] The present invention aims to provide a liquid chromatography-mass spectrometry (LC-MS) detection method for benzophenone ultraviolet absorbers in packaging materials, which can quickly quantitatively determine 8 benzophenone ultraviolet absorbers by using the LC-MS method, with high detection accuracy and precision and low detection limit.

[0006] A liquid chromatography-mass spectrometry (LC-MS) detection method for benzophenone ultraviolet absorbers in packaging materials includes the following steps:

[0007] S1. Prepare a standard solution and a sample solution to be measured. Weigh the sample and place it in a container, add methanol, ultrasonically extract after full infiltration, and filter to obtain the sample solution to be measured;

[0008] S2. Respectively take the test sample solution and the standard solution for analysis by liquid chromatography-mass spectrometry to detect the concentration of the ultraviolet absorber in the test sample solution;

[0009] Among them, the chromatographic column in the liquid chromatography-mass spectrometry is a C18 stationary phase chromatographic column, mobile phase A: 0.1% formic acid water, mobile phase B: methanol; gradient elution is adopted, and the range of the volume of the mobile phase B changing with time is: 0 min to 1.0 min, 60% - 90% B; 1.0 min to 3.0 min, 90% - 95% B; 3.0 min to 8.0 min, 95% B; 8.1 min to 13.0 min, 60% B.

[0010] Furthermore, in step S1, the standard sample solution includes 4,4'-dihydroxybenzophenone, 2,4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone, benzophenone, 4,4'-difluorobenzophenone, (2-hydroxy-4-methoxyphenyl)phenylmethanone, 2-hydroxy-4-n-hexyloxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone; the standard solution is configured with 5 concentration gradients, and the concentration of each benzophenone ultraviolet absorber is successively 0.01 mg / L, 0.02 mg / L, 0.05 mg / L, 0.1 mg / L, 0.2 mg / L, 0.4 mg / L.

[0011] Furthermore, in step S1, the ultrasonic extraction temperature is 60 ± 5 °C, the ultrasonic extraction time is 60 ± 5 min, and the extracted extract passes through a 0.22 μm organic filter membrane.

[0012] Furthermore, in step S2, the column length of the chromatographic column in the liquid chromatography-mass spectrometry is 150 mm, the inner diameter is 2.1 mm, the particle size is 3.5 μm, and the column temperature is 40 °C; the injection volume is 10 μL; the flow rate is 0.5 mL / min.

[0013] Furthermore, the mass spectrometry conditions in the liquid chromatography-mass spectrometry are: CUR: 20 PSI; CAD: 8 PSI; GS1: 55 PSI; GS2: 55 PSI; ESI positive ion mode; ion source: electrospray ionization source ESI; ion source temperature: 500 °C; capillary voltage: 5500 V; mass spectrometry scanning mode: multiple reaction monitoring.

[0014] Further, inject the gradient standard solution into a liquid chromatography-tandem mass spectrometer, and determine the peak positions of various benzophenone ultraviolet absorbers by positive ion multiple reaction monitoring mode. Record the response values at each concentration. Using the concentration as the abscissa and the response value as the ordinate, establish a standard curve equation. Inject the sample solution to be measured into the liquid chromatography-mass spectrometer for detection and analysis, and record the response value. Calculate the concentration value of the sample solution to be measured according to the response value and the linear equation.

[0015] Further, the response value is the peak area or peak height.

[0016] Further, the ion pairs of each benzophenone ultraviolet absorber are as follows:

[0017] The quantitative ion pair of 4,4'-dihydroxybenzophenone is 215.1 / 121.1, and the qualitative ion pair is 215.1 / 93.2;

[0018] The quantitative ion pair of 2,4-dihydroxybenzophenone is 215.1 / 137.0, and the qualitative ion pair is 215.1 / 105;

[0019] (3-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone has a quantitative ion pair of 245.2 / 121.1 and a qualitative ion pair of 245.2 / 93.2;

[0020] The quantitative ion pair of benzophenone is 182.7 / 105.0, and the qualitative ion pair is 182.7 / 51.2;

[0021] The quantitative ion pair of 4,4'-difluorobenzophenone is 219.0 / 123.1, and the qualitative ion pair is 219.0 / 95.1;

[0022] (2-Hydroxy-4-methoxyphenyl)phenylmethanone has a quantitative ion pair of 229.0 / 151.0 and a qualitative ion pair of 229.0 / 105.0;

[0023] The quantitative ion pair of 2-hydroxy-4-n-hexyloxybenzophenone is 299.0 / 137.0, and the qualitative ion pair is 299.0 / 105.1;

[0024] The quantitative ion pair of 2-hydroxy-4-n-octyloxybenzophenone is 327.0 / 137.0, and the qualitative ion pair is 327.0 / 104.9.

[0025] Further, the monitoring method can simultaneously detect any several of 8 benzophenone ultraviolet absorbers including 4,4'-dihydroxybenzophenone, 2,4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone, benzophenone, 4,4'-difluorobenzophenone, (2-hydroxy-4-methoxyphenyl)phenylmethanone, 2-hydroxy-4-n-hexyloxybenzophenone, and 2-hydroxy-4-n-octyloxybenzophenone

[0026] Further, the method detection limit of each benzophenone ultraviolet absorber is 0.03 mg / kg, and the method quantification limit is 0.1 mg / kg.

[0027] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0028] The liquid chromatography-mass spectrometry detection method for benzophenone ultraviolet absorbers in a packaging material provided by the present invention uses methanol as the extraction solvent and performs ultrasonic extraction. The extract passes through a 0.22 μm organic filter membrane, and finally the benzophenone ultraviolet absorbers in the extract are determined by a liquid chromatography-mass spectrometry instrument. The instrument parameters are reasonably designed, and a reasonable gradient condition is designed to perform gradient elution on the sample solution to be measured, thereby improving the resolution, improving the peak shape, controlling the peak width, and gradient elution can reduce the background noise and improve the signal-to-noise ratio, thereby improving the detection limit and sensitivity; a standard solution with a certain concentration is added to the negative sample, and the measurement result is calculated based on a signal-to-noise ratio greater than 3 times to calculate the instrument detection limit. By converting the dilution factor, the detection limit of the 8 ultraviolet absorbers in the present invention is finally obtained as 0.03 mg / kg, and the quantification limit is 0.1 mg / kg, and the detection limit is relatively low; through the standard addition recovery experiment, the recovery rate is between 92.6% and 118.1%, and the relative standard deviation is between 1.6% and 3.8%. The experimental results show that the sample pretreatment operation of this method is simple, the precision is high, and the results are accurate and reliable. This method can be used for the quantitative analysis of 8 benzophenone ultraviolet absorbers in new cigarette packaging materials. Description of the Drawings

[0029] Figure 1 It is the total ion current (TIC) chromatogram of liquid chromatography-tandem mass spectrometry of 8 benzophenone substances in Example 1 of the present invention;

[0030] Figure 2 It is the chromatogram of the standard solution of 4,4'-dihydroxybenzophenone in Example 1 of the present invention;

[0031] Figure 3 It is the chromatogram of the standard solution of 2,4-dihydroxybenzophenone in Example 1 of the present invention;

[0032] Figure 4 It is the chromatogram of the standard solution of (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone in Example 1 of the present invention;

[0033] Figure 5 Chromatogram of benzophenone in the standard solution in Example 1 of the present invention;

[0034] Figure 6 Chromatogram of 4,4'-difluorobenzophenone in the standard solution in Example 1 of the present invention;

[0035] Figure 7 Chromatogram of (2-hydroxy-4-methoxyphenyl)phenylmethanone in the standard solution in Example 1 of the present invention;

[0036] Figure 8 Chromatogram of 2-hydroxy-4-n-hexyloxybenzophenone in the standard solution in Example 1 of the present invention;

[0037] Figure 9 Chromatogram of 2-hydroxy-4-n-octyloxybenzophenone in the standard solution in Example 1 of the present invention. Detailed implementation manners

[0038] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0039] Example 1

[0040] The instruments and reagents are

[0041] Instruments: 100 μl and 1000 μl pipettes, Eppendorf; ultrasonic extractor SB25-12DTS, Ningbo Xinzhi Biotechnology Co., Ltd.; API 4000+ liquid chromatography triple quadrupole tandem mass spectrometer, AB SCIEX;

[0042] Analytical balance (accurate to 0.0001 g)

[0043] Ultrasonic extractor

[0044] Reagents: methanol (chromatographically pure), acetonitrile (chromatographically pure), Merck; benzophenone mixed standard (1000 mg / L), Ink Quality Inspection Standard Substance Center.

[0045] A method for liquid chromatography-mass spectrometry detection of benzophenone ultraviolet absorbers in cigarette packaging materials, comprising the following steps:

[0046] S1. Prepare standard solutions and sample solutions to be measured;

[0047] The standard solutions include: 4,4'-dihydroxybenzophenone, 2,4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone, benzophenone, 4,4'-difluorobenzophenone, (2-hydroxy-4-methoxyphenyl)phenylmethanone, 2-hydroxy-4-n-hexyloxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone; Five concentration gradients are configured for the standard solutions, and the concentrations of each benzophenone ultraviolet absorber are successively 0.01 mg / L, 0.02 mg / L, 0.05 mg / L, 0.1 mg / L, 0.2 mg / L, and 0.4 mg / L;

[0048] Test sample solutions: Set the cigarette packages of 6 different brands as Samples 1 - 6. Cut each sample into pieces with a particle size not greater than 0.5 mm. Weigh 1.0 g of the sample (accurate to 0.0001 g) into a 20 mL headspace vial, add 20 mL of methanol, seal it. After fully soaking the sample, place it in an ultrasonic extractor and ultrasonicate at 60 °C for 60 min. Filter the supernatant through a 0.22 μm filter membrane to obtain Test Sample Solutions 1 - 6;

[0049] Prepare blank solution: In a 20 mL headspace vial, add 20 mL of methanol, seal it. After fully soaking the sample (the blank sample uses a degradable packaging film blended with polylactic acid (PLA) and poly(butylene adipate-co-terephthalate) (PBAT)), place it in an ultrasonic extractor and ultrasonicate at 60 °C for 60 min. Filter the supernatant through a 0.22 μm filter membrane to obtain the blank solution;

[0050] S2. Respectively take Test Sample Solutions 1 - 6 and the standard solutions and analyze them by liquid chromatography - mass spectrometry to detect the concentration of the ultraviolet absorber in the test sample solutions;

[0051] The liquid chromatography conditions are as follows:

[0052] Chromatographic column: C18 column, column length 150 mm, inner diameter 2.1 mm, particle size 3.5 μm; Mobile phase: Phase A is 0.1% formic acid in water, Phase B is methanol. Gradient elution conditions: 0 min - 1.0 min, 60% - 90% B; 1.0 min - 3.0 min, 90% - 95% B; 3.0 min - 8.0 min, 95% B; 8.1 min - 13.0 min, 60% B; Column temperature: 40 °C; Injection volume: 10 μL; Flow rate: 0.5 mL / min;

[0053] Mass spectrometry conditions: CUR: 20 PSI; CAD: 8 PSI; GS1: 55 PSI; GS2: 55 PSI; ESI positive ion mode; Ion source: Electrospray ionization source ESI; Capillary voltage: 5500 V; Ion source temperature: 500 °C; Mass spectrometry scanning mode: Multiple reaction monitoring (MRM);

[0054] Using a mixed standard solution of 8 benzophenone ultraviolet absorbers at 1 mg / L, the mass spectrometry parameters of the 8 compounds were optimized using the mass spectrometer optimization software. After testing, the ion pairs, declustering voltages, and collision gas energies of the 8 benzophenone ultraviolet absorbers are shown in Table 1. The total ion current (TIC) chromatograms of the 8 benzophenone substances by liquid chromatography-tandem mass spectrometry are as Figure 1 shown. Using the above instrument conditions for the detection of the 8 benzophenone substances can achieve good baseline separation, with sharp peaks and good symmetry, and at the same time obtain high sensitivity.

[0055] Table 1: Ion pairs, declustering voltages, and collision gas energies of benzophenone ultraviolet absorbers

[0056]

[0057] First, inject the standard solution into the liquid chromatography-mass spectrometry instrument, record the response values (peak areas) at each concentration, construct a calibration curve based on these data, and calculate the linear equation and correlation coefficient. The linear equations and correlation coefficients of the 8 benzophenone ultraviolet absorbers are shown in Table 2.

[0058] Table 2: Linear equations, correlation coefficients

[0059]

[0060]

[0061] According to the test method, spiked recovery tests were carried out on blank samples at three different concentration levels of low, medium, and high. Each concentration level was measured in parallel 6 times. The spiked recovery tests were carried out at the addition levels of 0.1, 0.5, and 2.0 mg / kg, and the average recovery rate and relative standard deviation (RSD%) were calculated. The average recovery rates of 0.1, 0.5, and 2.0 mg / kg added were 92.6% - 98.2%, 95.2% - 102.5%,

[0062] 99.0% - 118.1% respectively, and the relative standard deviations were between 2.2% - 3.8%, 1.6% - 4.1%, and 1.8% - 3.5% respectively, indicating that this method has high accuracy and good precision and can meet the analysis requirements; the average standard addition recovery rates and relative standard deviations of the 8 benzophenone ultraviolet absorbers are shown in Table 3.

[0063] Table 3: Average standard addition recovery rates and relative standard deviations of 8 benzophenone ultraviolet absorbers (n = 6)

[0064]

[0065] In Table 3, ND: indicates below the method detection limit.

[0066] Add a standard solution with a certain concentration to the negative sample, and calculate the instrument detection limit based on the measurement result being greater than 3 times the signal-to-noise ratio. By converting the dilution factor, the detection limits of the 8 ultraviolet absorbers in this method are finally obtained as 0.03 mg / kg, which can fully meet the actual detection requirements.

[0067] Inject sample solutions to be measured 1 - sample solutions to be measured 6 into the liquid chromatography - mass spectrometer for detection and analysis, record the response values, and calculate the concentration values of sample solutions to be measured 1 - sample solutions to be measured 6 according to the response values and the linear equation; the detection results of sample solutions to be measured 1 - sample solutions to be measured 6 are shown in Table 4;

[0068] Table 4 Sample Detection Results Table Unit: mg / kg

[0069]

[0070] In Table 4, ND: indicates below the method detection limit.

[0071] In summary, using methanol as the extraction solvent, extract at 60 °C for 60 min on an ultrasonic extractor. The extract passes through a 0.22 μm organic filter membrane, and finally, the benzophenone ultraviolet absorbers in the extract are determined by a liquid chromatography - mass spectrometry combined instrument. Through the standard addition recovery experiment, the recovery rate is between 92.6% and 118.1%, and the relative standard deviation is between 1.6% and 3.8%. The experimental results show that the sample pretreatment operation of this method is simple, has high precision, and the results are accurate and reliable. This method can be used for the quantitative analysis of 8 benzophenone ultraviolet absorbers in new cigarette packaging materials.

[0072] The above are only the embodiments of the present invention, and common specific technical solutions or characteristics and the like in the solution are not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can still be made, and these should also be regarded as the protection scope of the present invention, and these will not affect the implementation effect of the present invention and the practicality of the patent. The protection scope required by this application should be subject to the content of its claims, and the specific implementation manners and the like described in the specification can be used to interpret the content of the claims.

Claims

1. A liquid chromatography-mass spectrometry method for detecting benzophenone ultraviolet absorbers in packaging materials, characterized in that: The following steps are involved: S1. Prepare a standard solution and a sample solution to be tested, weigh the sample and place it in a container, add methanol, extract it with ultrasound after fully soaking it, and filter it to obtain a sample solution to be tested; S2, respectively taking the sample solution to be tested and the standard solution for analysis by liquid chromatography-mass spectrometry to detect the concentration of the ultraviolet absorber in the sample solution to be tested; The chromatographic column in the liquid chromatography-mass spectrometry method is a C18 stationary phase chromatographic column, mobile phase A: 0.1% formic acid water, mobile phase B: methanol; gradient elution is adopted, and the volume of the mobile phase B changes with time in the range of: 0min~1.0min, 60%~90% B; 1.0min~3.0min, 90%~95% B; 3.0min~8.0min, 95%B; 8.1min~13.0min, 60%B.

2. The method for detecting benzophenone ultraviolet absorbers in packaging materials by liquid chromatography-mass spectrometry according to claim 1, characterized in that: In step S1, the standard sample solution includes 4,4'-dihydroxybenzophenone, 2,4-hydroxybenzophenone, (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone, benzophenone, 4,4'-difluorobenzophenone, (2-hydroxy-4-methoxyphenyl) phenyl ketone, 2-hydroxy-4-n-hexyloxybenzophenone, and 2-hydroxy-4-n-octyloxybenzophenone; the standard solution is configured with 5 concentration gradients, in which the concentration of each benzophenone ultraviolet absorber is 0.01 mg / L, 0.02 mg / L, 0.05 mg / L, 0.1 mg / L, 0.2 mg / L, and 0.4 mg / L, respectively.

3. The method for detecting benzophenone ultraviolet absorbers in packaging materials by liquid chromatography-mass spectrometry according to claim 1, characterized in that: In step S1, the ultrasonic extraction temperature is 60±5°C, the ultrasonic extraction time is 60±5min, and the extracted extract passes through a 0.22μm organic filter membrane.

4. The method for detecting benzophenone ultraviolet absorbers in cigarette packaging materials by liquid chromatography-mass spectrometry according to claim 1, characterized in that: In step S2, the column length of the chromatographic column in the liquid chromatography-mass spectrometry is 150 mm, the inner diameter is 2.1 mm, the particle size is 3.5 um, the column temperature is 40°C; the injection volume is 10 uL; and the flow rate is 0.5 mL / min.

5. The method for detecting benzophenone ultraviolet absorbers in packaging materials by liquid chromatography-mass spectrometry according to claim 1, characterized in that: In step S2, the mass spectrometry conditions in the liquid chromatography-mass spectrometry are: CUR: 20PSI; CAD: 8PSI; GS1: 55PSI; GS2: 55PSI; ESI positive ion mode; Ion source: electrospray ionization source ESI; ion source temperature: 500°C; capillary voltage: 5500V; mass spectrometry scanning mode: multiple reaction monitoring.

6. The method for detecting benzophenone ultraviolet absorbers in packaging materials by liquid chromatography-mass spectrometry according to claim 2, characterized in that: The gradient standard solution is injected into a liquid chromatography-tandem mass spectrometer, and the peak positions of various benzophenone ultraviolet absorbers are determined in a positive ion multiple reaction monitoring mode. The response value at each concentration is recorded, and a standard curve equation is prepared with the concentration as the horizontal axis and the response value as the vertical axis; the sample solution to be tested is injected into a liquid chromatography-mass spectrometer for detection and analysis, and the response value is recorded. According to the response value and the linear equation, the concentration value of the sample solution to be tested is calculated.

7. The method for detecting benzophenone ultraviolet absorbers in packaging materials by liquid chromatography-mass spectrometry according to claim 6, characterized in that: The response value is peak area or peak height.

8. The method for detecting benzophenone ultraviolet absorbers in packaging materials by liquid chromatography-mass spectrometry according to claim 6, characterized in that: The mass spectrometry parameters of each benzophenone type UV absorber are: The quantitative ion pair of 4,4'-dihydroxybenzophenone is 215.1 / 121.1, and the qualitative ion pair is 215.1 / 93.2; The quantitative ion pair of 2,4-hydroxybenzophenone is 215.1 / 137.0, and the qualitative ion pair is 215.1 / 105; The quantitative ion pair of (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanone is 245.2 / 121.1, and the qualitative ion pair is 245.2 / 93.2; The quantitative ion pair of benzophenone was 182.7 / 105.0, and the qualitative ion pair was 182.7 / 51.2; The quantitative ion pair of 4,4'-difluorobenzophenone is 219.0 / 123.1, and the qualitative ion pair is 219.0 / 95.1; The quantitative ion pair of (2-hydroxy-4-methoxyphenyl)phenylmethanone is 229.0 / 151.0, and the qualitative ion pair is 229.0 / 105.0; The quantitative ion pair of 2-hydroxy-4-n-hexyloxybenzophenone is 299.0 / 137.0, and the qualitative ion pair is 299.0 / 105.1; The quantitative ion pair of 2-hydroxy-4-n-octyloxybenzophenone was 327.0 / 137.0, and the qualitative ion pair was 327.0 / 104.

9.

9. The method for detecting benzophenone ultraviolet absorbers in packaging materials by liquid chromatography-mass spectrometry according to claim 1, characterized in that: It can simultaneously detect any of the eight benzophenone ultraviolet absorbers, including 4,4'-dihydroxybenzophenone, 2,4-hydroxybenzophenone, (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone, benzophenone, 4,4'-difluorobenzophenone, (2-hydroxy-4-methoxyphenyl) phenyl ketone, 2-hydroxy-4-n-hexyloxybenzophenone, and 2-hydroxy-4-n-octyloxybenzophenone.

10. The method for detecting benzophenone ultraviolet absorbers in packaging materials by liquid chromatography-mass spectrometry according to claim 9, characterized in that: The detection limit of each benzophenone type UV absorber was 0.03 mg / kg, and the quantification limit was 0.1 mg / kg.

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