Skull cap and experimental device

Abstract

The invention provides a skull cap and an experimental device. The skull cap comprises a skull cap body and a first sliding device, the first sliding device comprises a fixing piece and a sliding piece, wherein the fixing piece is fixedly arranged on one side of the skull cap body in the first direction; and the sliding part is used for fixing the probe and is arranged on the fixed part in a sliding manner along the first direction. According to the embodiment of the invention, the probe is driven to move on the skull cap by arranging the sliding part which slides on the fixed part along the first direction, so that the probe can collect animal brain region signals in the first direction; the technical problem that the signal acquisition area of the probe is limited due to the fact that the position of the probe relative to the skull cap is fixed in the prior art is solved.

Description

Technical Field

[0001] This application belongs to the technical field of animal experiments, and more specifically, relates to a skull cap and an experimental device. Background Art

[0002] When using probes such as ultrasonic probes and mini microscopes in scientific research experiments to record brain nerve activities or perform neural regulation on freely moving mice, it is necessary to keep the relative position between the animal probe and the brain fixed.

[0003] For example, for mice, in the current skull caps used for freely moving mice, after fixing the skull cap to the mouse skull using dental cement, the probe is then fixed to the skull cap. That is to say, the position between the probe and the brain is completely fixed. However, the response of the brain to a certain stimulus often involves multiple brain regions. Therefore, it is necessary to perform signal acquisition or neuron regulation operations on multiple brain regions. Since the existing skull cap completely fixes the position of the probe on the skull, for freely moving mice in related technologies, the probe can only collect signals from local brain regions. Summary of the Invention

[0004] To solve the technical problem in related technologies that the area where the probe collects signals is limited due to the fixed position of the probe relative to the skull cap, the purpose of this application is to provide a skull cap and an experimental device.

[0005] In a first aspect, an embodiment of this application provides a skull cap, including a skull cap body and a first sliding device; the first sliding device includes:

[0006] A fixing member fixedly arranged on one side of the skull cap body along a first direction;

[0007] And a sliding member for fixing the probe, slidably arranged on the fixing member along the first direction.

[0008] Further, the sliding member is provided with a placement cavity; the placement cavity has a first opening and a second opening; the second opening faces the side of the skull cap body; the placement cavity is used for slidably connecting with the probe. When the probe is placed into the placement cavity from the first opening, the lens of the probe faces the second opening; the length of the placement cavity in a second direction is greater than the length of the probe in the second direction so that the probe can slide in the placement cavity along the second direction.

[0009] Further, the skull cap body is fixedly provided with a connecting member; the connecting member includes:

[0010] A first part, one end of which is connected to one end of the fixing member;

[0011] The second piece is fixedly connected to the other end of the first piece and forms an obtuse angle with the first piece;

[0012] And a first mounting portion is provided at the connection between the first piece and the second piece for connecting with the skull cap body.

[0013] Furthermore, the connecting member includes:

[0014] A first connecting member is connected to one end of the fixing member;

[0015] And a second connecting member is connected to the other end of the fixing member;

[0016] The fixing member includes:

[0017] An elongated member is fixedly provided on one side of the skull cap body along a first direction;

[0018] The elongated member includes a first elongated member and a second elongated member; the first elongated member and the second elongated member are parallel; both ends of the first elongated member are respectively connected to the first piece of the first connecting member and the first piece of the second connecting member; both ends of the second elongated member are respectively connected to the second piece of the first connecting member and the second piece of the second connecting member; both sides of the sliding member are respectively slidably sleeved on the outer sides of the first elongated member and the second elongated member.

[0019] In a second aspect, an embodiment of the present application provides an experimental device including the skull cap.

[0020] Furthermore, it further includes a pulling device, and the pulling device includes:

[0021] A power device;

[0022] A first wire, one end of which is fixedly connected to one end of the sliding member and the other end is connected to the power device;

[0023] And a second wire, one end of which is fixedly connected to the other end of the sliding member and the other end is connected to the power device;

[0024] The first connecting member is further provided with a fixing hole, and one end of the first piece is further provided with a supporting portion; one end of the first wire sequentially bypasses the outside of the supporting portion, passes through the fixing hole and then is connected to one end of the sliding member, so that when the power device pulls the first wire, the sliding member slides along the first direction towards the first connecting member; when the power device pulls the second wire, the sliding member slides along the first direction towards the second connecting member.

[0025] Furthermore, the experimental device further includes a moving device; the moving device includes:

[0026] The first plate and the sliding mechanism;

[0027] The sliding mechanism includes:

[0028] A roller for magnetically rolling connection with the first plate;

[0029] A pulley;

[0030] And a connecting frame, one side of which is connected to the roller through a first rotating shaft and the other side is connected to the pulley through a second rotating shaft;

[0031] The first wire, the second wire and the connecting wire of the probe are wound around the pulley and then connected to the sliding member.

[0032] Furthermore, the first plate is also provided with a sliding member; there is a space for the transmission wire to pass through between the sliding member and the first plate; the transmission wire includes the first wire, the second wire and the connecting wire of the probe; when the transmission wire passes through the space, a counterweight is hung on the part of the transmission wire between the pulley and the space so that the transmission wire is in sliding contact with the outside of the sliding member.

[0033] Furthermore, the power device includes:

[0034] A motor;

[0035] A driving wheel connected to the motor;

[0036] A mounting plate provided on one side of the motor, having a first elongated hole and a second elongated hole;

[0037] And a tensioner;

[0038] The tensioner includes:

[0039] A first tensioner connected to the driving wheel through the first wire and installed in the first elongated hole;

[0040] And a second tensioner connected to the driving wheel through the first wire and installed in the second elongated hole.

[0041] Furthermore, the parts of the first wire and the second wire between the tensioner and the skull cap are wrapped with a hose;

[0042] The skull cap further includes:

[0043] A first wire fixing member provided on the first connecting member of the connecting member for fixing the hose of the first wire;

[0044] And a second wire fixing member provided on the second connecting member of the connecting member for fixing the hose of the second wire;

[0045] And a hose holder provided on the mounting plate, having a first hole for fixing the hose of the first line and a second hole for fixing the hose of the second line.

[0046] A skull cap and an experimental device according to an embodiment of the present application realize the acquisition of signals from the animal brain region by the probe in the first direction by setting a sliding member that slides on the fixing member along the first direction to drive the probe to move on the skull cap, thereby solving the technical problem in the related art that the area for signal acquisition by the probe is limited due to the fixed position of the probe relative to the skull cap. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for use in the embodiments or the description of the prior art. Obviously, the following drawings are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0048] Figure 1 It is a schematic structural diagram of a skull cap body having a connecting member.

[0049] Figure 2 It is a schematic structural diagram of the first sliding device.

[0050] Figure 3 It is a front view of the first sliding device.

[0051] Figure 4 It is a schematic structural diagram of the skull cap.

[0052] Figure 5 It is a schematic overall structural diagram of the experimental device.

[0053] Figure 6 It is a three-dimensional structural diagram of the experimental device after removing the box body.

[0054] Figure 7 It is a three-dimensional structural diagram of the experimental device after removing the first plate.

[0055] Figure 8 It is a three-dimensional structural diagram of the sliding mechanism.

[0056] Among them, the marks in the figure:

[0057] 101 - Skull cap body, 102 - Ear hole, 103 - First piece, 104 - Second piece, 105 - Support part, 106 - Fixing hole, 107 - First line fixing piece, 108 - Second line fixing piece, 109 - Connecting block, 111 - Second long piece, 112 - Fixing frame, 113 - Placing cavity, 114 - First long piece, 115 - First line, 116 - Second line, 11 - Sliding piece, 10 - Fixing piece, 1 - Animal, 2 - Counterweight, 3 - Moving device, 4 - Power device, 5 - Probe, 51 - Connecting wire, 6 - Sliding part, 7 - First plate, 8 - Box body, 301 - Roller, 302 - First rotating shaft, 303 - First U-shaped frame, 304 - Connecting piece, 305 - Second U-shaped frame, 306 - Second rotating shaft, 307 - Pulley, 401 - Motor, 402 - Driving wheel, 403 - Mounting plate, 404 - Second strip-shaped hole, 405 - First strip-shaped hole, 406 - Second tensioner, 407 - First tensioner, 408 - First hose, 409 - Second hose, 410 - Hose fixer. Detailed implementation mode

[0058] In order to make the technical problems, technical solutions and beneficial effects to be solved by this application clearer, the following further elaborates on this application in conjunction with the attached drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain this application and are not used to limit this application.

[0059] It should be noted that when an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0060] It should be understood that the orientation or positional relationship indicated by the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the attached drawings. It is only for the convenience of describing this application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to this application.

[0061] In addition, the terms "first" and "second" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of this application, "a plurality" means two or more, unless otherwise specifically defined.

[0062] When using probes such as ultrasonic probes and mini microscopes to record brain nerve activities or perform neuromodulation on freely moving mice in scientific research experiments, it is necessary to keep the relative position between the probe and the brain fixed.

[0063] Currently, for skull caps used on freely moving animals such as moving mice, after fixing the skull cap to the mouse skull using dental cement, the probe is then fixed to the skull cap. That is to say, the position between the probe and the brain is completely fixed.

[0064] However, the response of the brain to a certain stimulus often involves multiple brain regions. Since the existing skull cap completely fixes the position of the probe on the skull, that is to say, for a freely moving mouse, the probe can only perform signal acquisition or neuron regulation operations on local brain regions. For a freely moving mouse, how to make the probe reach any position within the brain range during the process of brain nerve activity recording or manipulation poses a challenge. If a motor is placed on the mouse's head, it will increase the load capacity of the mouse and seriously affect the free movement of the mouse; in addition, during use, it is necessary to hold the cable of the probe and continuously adjust the position as the mouse moves, which is not convenient for long-term recording, and manually manipulating the cable will also bring instability and noise to the experiment.

[0065] To solve the technical problem in the related art that the area where the probe collects signals is limited due to the fixed position of the probe relative to the skull cap, on the one hand, an embodiment of the present application provides a skull cap. Refer to Figure 1-4 As shown, it includes a skull cap body and a first sliding device; the first sliding device includes: a fixing member 10 and a sliding member 11. Both ends of the fixing member are fixedly arranged on one side of the skull cap body 101 along a first direction; the sliding member 11 is used to fix the probe 5, and the sliding member 11 is slidably arranged on the fixing member 10 along the first direction.

[0066] The first direction can be a horizontal direction, a vertical direction, or other directions. In some embodiments, the first direction is the front-back direction of the skull cap body, that is, the direction corresponding to the top of the animal's head to the neck.

[0067] Refer to Figure 1 As shown, one side of the skull cap body 101 refers to the upper or lower spatial region of the skull cap body 101. Optionally, one side of the skull cap body 101 refers to the non-wearing side of the skull cap body 101. Both ends of the fixing member 10 being arranged along the first direction means that both ends of the fixing member 10 are in the first direction.

[0068] The slider 11 is slidably arranged on the fixed part and can slide on the fixed part 10 along the first direction. The probe is fixed on the slider 11. By adopting the above method, the probe can be driven by the slider 11 to move back and forth on the fixed part 10, thereby expanding the area where the probe collects information and solving the technical problem that the area where the probe collects signals is limited due to the fixed position of the probe relative to the skull cap.

[0069] Therefore, in the embodiment of the present application, by arranging a slider that slides on the fixed part along the first direction to drive the probe to move on the skull cap, the acquisition of signals from the animal brain region in the first direction by the probe is realized, and the technical problem that the area where the probe collects signals is limited due to the fixed position of the probe relative to the skull cap in the related art is solved.

[0070] In some embodiments, the slider 11 is provided with a placement cavity 113; the placement cavity has a first opening and a second opening; the second opening faces the side of the skull cap body 101; the placement cavity is used for slidably connecting with the probe. When the probe is placed into the placement cavity from the first opening, the lens of the probe faces the second opening; the length of the placement cavity in the second direction is greater than the length of the probe in the second direction so that the probe can slide in the placement cavity along the second direction.

[0071] Refer to Figure 2 As shown, the slider includes a fixing frame 112 and a placement cavity 113; the placement cavity is arranged on the fixing frame 112. The first opening of the placement cavity 113 can be located on the upper side of the placement cavity 113, and the second opening is located on the lower side of the placement cavity 113. When the probe is placed into the placement cavity 113 from the first opening, the lens of the probe faces the second opening and just aligns with the animal brain region.

[0072] The second direction can be a direction perpendicular to or intersecting with the first direction, or a direction parallel to the first direction. Optionally, the second direction is a direction perpendicular to the first direction. When the first direction is the front-back direction of the skull cap body 101, the second direction is the left-right direction of the skull cap body 101.

[0073] The length of the placement cavity in the second direction is greater than the length of the probe in the second direction, so that the probe can slide in the second direction of the placement cavity. Optionally, the length of the placement cavity in the second direction is 2-5 times greater than the length of the probe in the second direction.

[0074] When the lower side of the skull cap body 101 is fixed on the animal's head, the slider 11 slides in the front-back direction of the fixed part 10, and the probe slides in the left-right direction in the placement cavity of the slider 11, so that the area for the probe to obtain brain region image information can cover the upper side of the entire skull cap body 101.

[0075] In some embodiments, a connecting member is fixedly provided on the skull cap body 101; the connecting member includes: a first member 103, a second member 104, and a first mounting portion; one end of the first member 103 is connected to one end of the fixing member; the second member 104 is fixedly connected to the other end of the first member 103, and the included angle between the second member 104 and the first member 103 is an obtuse angle; the first mounting portion is provided at the connection between the first member 103 and the second member 104, and the first mounting portion is used for connecting with the skull cap body.

[0076] Referring to Figure 1 As shown, optionally, a connecting member is provided on each of the front and rear sides of the skull cap body; the connecting member includes a first connecting member and a second connecting member; the first connecting member is connected to one end of the fixing member, and the second connecting member is connected to the other end of the fixing member. The first connecting member and the second connecting member are the same. The first connecting member is provided on the front side of the skull cap body, and the second connecting member is provided on the rear side of the skull cap body.

[0077] Optionally, taking the first connecting member as an example. The first connecting member includes the first member 103 and the second member 104; with the connection between the first member 103 and the second member 104 as the center, the first member 103 and the second member 104 are centrosymmetric about the center of this connection. Optionally, the first member 103 and the second member 104 are the same. The left end of the first member 103 is connected to the right end of the second member 104, and the included angle between the first member 103 and the second member 104 is an obtuse angle, which can make the connecting member occupy as little space as possible on the upper side of the skull cap body and make the distance between the right end of the first member 103 and the left end of the second member 104 larger, so that the moving area of the probe on the upper side of the skull cap body is larger. Optionally, ear holes 102 for fixing the animal ear part are provided on the skull cap body; the skull cap body is fixedly connected to the mounting hole of the first mounting portion through a connecting block 109. This fixed connection method can be a snap connection or other detachable connection methods, which are not limited here.

[0078] Based on the above manner of the connecting member, correspondingly, the fixing member includes two long members; a long member is provided on each of the left and right sides of the skull cap body. The long member is fixedly provided on one side of the skull cap body along the first direction.

[0079] The long member includes a first long member 114 and a second long member 111; the first long member 114 and the second long member 111 are fixedly provided in the upper space of the skull cap body 101 along the first direction.

[0080] Referring to Figure 4As shown, the front and rear ends of the first elongated member 114 are respectively connected to the right end of the first member 103 of the first connecting member and the right end of the first member 103 of the second connecting member; both ends of the second elongated member 111 are respectively connected to the left end of the second member 104 of the first connecting member and the left end of the second connecting member; both sides of the sliding member are respectively sleeved on the outer sides of the first elongated member and the second elongated member. Specifically, referring to Figure 2 As shown, the first elongated member 114 and the second elongated member 111 are parallel; both the left and right sides of the fixing frame 112 are respectively sleeved on the outer sides of the first elongated member 114 and the second elongated member 111.

[0081] In addition, the components of the first sliding device of the skull cap are detachably designed with the skull cap body. When not in use, the components can be separated. During non-experimental processes, the animal's head only needs to carry the skull cap body, reducing the impact on the animal's head.

[0082] In a second aspect, an embodiment of the present application provides an experimental device, including the aforementioned skull cap.

[0083] Specifically, referring to Figure 5-6 As shown, the experimental device further includes a box body 8, and there is an animal 1 under the skull cap body 101. The experimental device further includes a pulling device, and the pulling device includes: a power device 4, a first wire 115, and a second wire 116; one end of the first wire 115 is fixedly connected to one end of the sliding member, and the other end of the first wire 115 is connected to the power device 4; one end of the second wire 116 is fixedly connected to the other end of the sliding member, and the other end of the second wire 116 is connected to the power device.

[0084] Referring to Figure 2-4 As shown, the moving principle of the sliding member on the skull cap is as follows: the front end of the first wire 115 is connected to the front end of the sliding member, and the second wire 116 is connected to the rear end of the sliding member; when the first wire 115 is pulled, the sliding member can be driven to move towards the front end of the skull cap body 101, and when the second wire 116 is pulled, the sliding member can be driven to move towards the rear end of the skull cap body 101. By adopting the above method, the sliding member can be driven to move in the front-rear direction on the upper side of the skull cap body 101. The power device provides pulling force for the first wire and the second wire.

[0085] In some embodiments, the first connecting member is further provided with a fixing hole 106, and one end of the first member 103 is further provided with a supporting portion 105; one end of the first wire sequentially bypasses the outside of the supporting portion, passes through the fixing hole and then is connected to one end of the sliding member, so that when the power device pulls the first wire, the sliding member slides towards the first connecting member along the first direction; when the power device pulls the second wire, the sliding member slides towards the second connecting member along the first direction.

[0086] Refer to Figure 3 As shown, optionally, the fixing hole 106 is provided directly above the connection between the first part 103 and the second part 104 of the first connecting member. The side of the fixing hole 106 has an opening to facilitate the first wire 115 to be snapped into the fixing hole 106.

[0087] Refer to Figure 3-4 As shown, in some embodiments, in order to provide a supporting force for the first wire 115, a supporting portion 105 is provided at the upper right end of the first part 103. The front end of the first wire reaches the outside of the supporting portion along the first direction, contacts the outside of the supporting portion, then continues to wind around the fixing hole 106 in the second direction, and then passes through the fixing hole 106 and is connected to the central portion of the front end of the sliding member. When the first wire is pulled, due to the existence of the supporting portion and the fixing hole, the acting force of the first wire can be concentrated on the central portion of the front end of the sliding member to drive the sliding member to move on the first elongated member 114 and the second elongated member 111 in the direction close to the front end of the skull cap body.

[0088] Optionally, the second wire is connected to the central portion of the rear end of the sliding member. In the case of pulling the second wire, the second wire can drive the sliding member to move on the first elongated member 114 and the second elongated member 111 in the direction close to the rear end of the skull cap body.

[0089] In order to facilitate the free movement of the animal during the experiment, the experimental device further includes a moving device 3; the moving device 3 includes: a first plate 7 and a sliding mechanism;

[0090] The sliding mechanism includes: a roller 301, a pulley 307 and a connecting frame; the roller is used for magnetically rolling connection with the first plate 7; one side of the connecting frame is connected to the roller 301 through a first rotating shaft 302, and the other side of the connecting frame is connected to the pulley 307 through a second rotating shaft 306; the first wire, the second wire and the connecting wire of the probe are wound around the pulley and then connected to the sliding member. Optionally, the pulley 307 is a fixed pulley. The sliding mechanism ensures that the mouse can move freely in the activity room for a long time, reduces human intervention and improves the experimental stability.

[0091] Refer to Figure 8 As shown, the connecting frame includes a first U-shaped frame 303, a connecting piece 304 and a second U-shaped frame 305; the first U-shaped frame 303 is connected to the second U-shaped frame 305 through the connecting piece 304. The roller 301 is installed on the first U-shaped frame 303 through the first rotating shaft 302; the pulley 307 is installed on the second U-shaped frame 305 through the second rotating shaft 306.

[0092] The first plate 7 is provided at the top of the box body 8, and the first plate 7 is magnetically connected to the roller 301, so that the roller 301 can roll freely on the first plate. It can be understood that the roller is made of magnetic material, and the first plate is made of magnetic conductive material; or the roller is made of magnetic conductive material, and the first plate is made of magnetic material. Both can achieve the magnetic connection between the first plate 7 and the roller 301.

[0093] Optionally, one end of the first wire is bypassed by the power device outside the pulley 307, outside the support portion 105, passes through the fixing hole 106 and is connected to the front end of the sliding member 11; one end of the second wire is bypassed by the power device outside the pulley 307 and connected to the rear end of the sliding member 11; after the connecting wire of the probe is wound around the pulley 307, the probe is placed in the placement cavity of the sliding member.

[0094] Thus, when the animal moves freely while wearing the skull cap, the first sliding device on the skull cap drives the roller of the sliding mechanism to move on the first plate, so that the skull cap body and the first sliding device can move with the free movement of the animal.

[0095] Since the probe, the skull cap and the first sliding device have a large weight, which will cause a large burden on the animal's head. To reduce this burden. In some embodiments, the first plate is further provided with a sliding member 6; optionally, the sliding member is a sliding rod. There is a space for the transmission wire to pass through between the sliding member 6 and the first plate 7; the transmission wire includes the first wire, the second wire and the connecting wire 51 of the probe; when the transmission wire passes through the space, a counterweight 2 is hung on the part of the transmission wire between the pulley and the space so that the transmission wire is in sliding contact with the outside of the sliding member.

[0096] Refer to Figure 6 and 7 As shown, the sliding member 6 is arranged in the width direction of the first plate 7, there is a gap between the sliding member 6 and the first plate, and the transmission wire passes through the gap and is hung on the pulley 307; a counterweight 2 is arranged on the part of the transmission wire between the pulley 307 and the sliding member 6. Optionally, the weight of the counterweight 2 is the same as the total weight of the skull cap, the first sliding device and the probe 5. Thus, due to the function of the pulley 307, the counterweight 2 can offset the burden on the animal's head caused by the skull cap, the first sliding device and the probe. The pulley 307 can be a single pulley or a combination of multiple pulleys, which is not limited here.

[0097] The counterweight balances the weight of the mouse skull load, making it more convenient for the mouse to move and allowing it to easily perform actions such as raising the head, lowering the head, turning left and turning right; the sliding mechanism is connected to the first plate at the top of the box body by means of magnetic attraction, enabling the mouse to move freely at any position within the box.

[0098] Further, the power device includes: a motor 401, a drive wheel 402, a mounting plate 403, and a tensioner; the drive wheel 402 is connected to the motor; the mounting plate 403 is disposed on one side of the motor, and the mounting plate 403 is provided with a first elongated hole 405 and a second elongated hole 404;

[0099] The tensioner includes a first tensioner 407 and a second tensioner 406. The first tensioner 407 is connected to the drive wheel through the first line, and the first tensioner 407 is mounted in the first elongated hole 405; the second tensioner 406 is connected to the drive wheel 402 through the first line 115, and the second tensioner 406 is mounted in the second elongated hole 404.

[0100] Optionally, the first line 115 can be connected to the second line 116 and then sleeved on the drive wheel, or the first line 115 is fixedly connected to the right side of the drive wheel, and the second line is fixedly connected to the left side of the drive wheel. When the drive wheel rotates clockwise or counterclockwise, the first line and the second line are correspondingly pulled, thereby driving the forward and backward movement of the sliding member. The first tensioner 407 and the second tensioner 406 can adjust the tension of the first line and the second line, and the first elongated hole 405 and the second elongated hole 404 can adjust the installation positions of the first tensioner 407 and the second tensioner 406, thereby assisting in adjusting the tension of the first line and the second line.

[0101] When the first line and the second line are made of a relatively soft material, in order to make the first line and the second line have a relatively stable shape, a hose is wrapped around the outside of the first line and the second line.

[0102] Further, the portions of the first line and the second line located between the tensioner and the skull cap are wrapped with a hose.

[0103] Refer to Figure 7 As shown, in order to facilitate fixing the position of the hose, the skull cap further includes a first line fixing member 107, a second line fixing member 108, and a hose holder 410. The outer layer of the first line is wrapped with a first hose 408, and the outer layer of the second line is wrapped with a second hose 409. The first line fixing member 107 is disposed on the first connecting member of the connecting member, and the first line fixing member 107 is used to fix the first hose 408 of the first line; the second line fixing member 108 is disposed on the second connecting member of the connecting member, and the second line fixing member 108 is used to fix the first hose 409 of the second line; the hose holder 410 is disposed on the mounting plate 403 and has a first hole for fixing the hose of the first line and a second hole for fixing the hose of the second line.

[0104] Refer to Figure 7As shown, the hose holder 410 is installed on the mounting plate 403. After the hose holder 410 fixes the first hose and the second hose, the first wire is connected to the driving wheel through the first tensioner 407, and the second wire is connected to the driving wheel after passing through the second tensioner 408. Refer to Figure 2 and 4 As shown, after the first wire fixing member 107 fixes the first hose 408, the first wire winds from the right side of the support portion 105 to the left side of the support portion 105 and then passes through the fixing hole 106 and is connected to the front end of the sliding member; after the second wire fixing member fixes the second hose, the second wire is connected to the center of the rear end of the sliding member.

[0105] Therefore, the first hose and the second hose can play a role in keeping the shape and form of the first wire and the second wire stable when pulling the first wire and the second wire. By using the flexible first wire, second wire and hoses, the technical problem of difficult integration of the first sliding device and the skull cap on the mouse skull due to weight / volume limitations is solved, and the functional requirement of the probe moving as needed is achieved.

[0106] The embodiment of the present application can solve the technical difficulty of the probe moving as needed during the process of brain signal recording or neuron regulation when the animal is freely moving, and provides an implementable technical solution for realizing 4D brain activity imaging and whole-brain scale scientific research.

[0107] The embodiment of the present application can be used not only for mice and rats, but also for various animals such as ferrets, pigs, cats and monkeys; it can be used not only on the head, but also on other parts, such as pasting the skull cap component on the chest to achieve long-term monitoring of the heart; the method of spatially separating the power source and the execution component proposed by the invention can also be applied in the industrial field, such as pipeline detection operations in narrow / high-altitude places, etc.

[0108] The above are only the preferred embodiments of the present application, and are not intended to limit the present application. Any modifications, equivalent replacements and improvements made within the spirit and principle of the present application shall be included within the protection scope of the present application.

Claims

1. A skull cap, characterized in that: It includes a skull cap body and a first sliding device; the first sliding device includes: A fixing member, fixedly arranged on one side of the skull cap body along a first direction; And a sliding member, used for fixing the probe, and slidably disposed on the fixing member along a first direction.

2. The skull cap according to claim 1, characterized in that: The sliding part is provided with a placement cavity; the placement cavity has a first opening and a second opening; the second opening faces one side of the skull cap body; the placement cavity is used to be slidably connected with the probe, and when the probe is placed into the placement cavity from the first opening, the lens of the probe faces the second opening; the length of the placement cavity in the second direction is greater than the length of the probe in the second direction so that the probe can slide in the placement cavity along the second direction.

3. The skull cap according to claim 1 or 2, characterized in that: The skull cap body is fixed with a connecting piece; the connecting piece comprises: A first piece, one end of which is connected to one end of the fixing piece; A second piece is fixedly connected to the other end of the first piece and has an obtuse angle with the first piece; And a first mounting portion is arranged at the connection between the first piece and the second piece and is used for connecting with the skull cap body.

4. The experimental device according to claim 3, characterized in that: The connecting piece comprises: A first connecting member connected to one end of the fixing member; and a second connecting member connected to the other end of the fixing member; The fixing member comprises: An elongated member fixedly mounted on one side of the skull cap body along a first direction; The elongated member includes a first elongated member and a second elongated member; the first elongated member and the second elongated member are parallel; the two ends of the first elongated member are respectively connected to the first member of the first connecting member and the first member of the second connecting member; the two ends of the second elongated member are respectively connected to the second member of the first connecting member and the second member of the second connecting member; the two sides of the sliding member are respectively slidably mounted on the outside of the first elongated member and the second elongated member.

5. An experimental device, characterized in that: The invention comprises the skull cap as described in any one of claims 1 to 4.

6. The experimental device according to claim 5, characterized in that: Also included is a pulling device, the pulling device comprising: Power plant; A first line, one end of which is fixedly connected to one end of the sliding member and the other end of which is connected to the power device; and a second wire, one end of which is fixedly connected to the other end of the sliding member and the other end of which is connected to the power device; The first connecting member is also provided with a fixing hole, and one end of the first member is also provided with a supporting portion; one end of the first wire is sequentially passed around the outside of the supporting portion, passes through the fixing hole, and is connected to one end of the sliding member, so that when the power device pulls the first wire, the sliding member slides along the first direction toward the first connecting member; when the power device pulls the second wire, the sliding member slides along the first direction toward the second connecting member.

7. The experimental device according to claim 6, characterized in that: Also includes a moving device; the moving device includes: a first plate and a sliding mechanism; The sliding mechanism comprises: A roller, used for magnetic rolling connection with the first plate; pulley; and a connecting frame, one side of which is connected to the roller via the first rotating shaft, and the other side of which is connected to the pulley via the second rotating shaft; The first wire, the second wire and the connecting wire of the probe are wound around the pulley and then connected to the sliding member.

8. The experimental device according to claim 7, characterized in that: The first plate is also provided with a slide; a space is provided between the slide and the first plate for the conductive wire to pass through; the conductive wire includes the first wire, the second wire and the connecting wire of the probe; when the conductive wire passes through the space, a counterweight block is hung on the portion of the conductive wire located between the pulley and the space to enable the conductive wire to slide in contact with the outer side of the slide.

9. The experimental device according to claim 8, characterized in that: The power unit comprises: Motor; A driving wheel connected to the motor; A mounting plate is arranged on one side of the motor and is provided with a first strip hole and a second strip hole; and tensioner; The tensioner comprises: A first tensioner, connected to the driving wheel via the first wire and mounted in the first strip hole; and a second tensioner connected to the driving wheel via the first wire and installed in the second strip hole.

10. The experimental device according to claim 9, characterized in that: Portions of the first wire and the second wire between the tensioner and the skull cap are wrapped with a hose; The skull cap also includes: a first line fixing member, provided on the first connecting member of the connecting member, and used for fixing the hose of the first line; a second line fixing member, provided on the second connecting member of the connecting member, and used for fixing the hose of the second line; and a hose holder arranged on the mounting plate, comprising a first hole for fixing the hose of the first line and a second hole for fixing the hose of the second line.

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