Nanometer knife for clinical tumor ablation treatment

Abstract

The invention discloses a nano-knife for clinical tumor ablation treatment. The nano-knife comprises a nano-knife electrode needle, and a puncture needle outer sleeve, a puncture sharp needle, a puncture blunt needle, a power supply containing and holding cylinder, a Luer taper and a round block which are matched with the nano-knife electrode needle for use. The puncture needle has the advantages that the puncture needle outer sleeve made of the matched insulation material is adopted, the gravity of the insulation puncture needle is small, and the influence of the gravity and the traction effect in the needle moving process is reduced; the puncture needle core is taken out, the puncture needle outer sleeve is reserved, the nanometer knife electrode needle can enter the tumor position through the puncture needle outer sleeve conveniently, and after the nanometer knife electrode needle is in place, the size of an electrode axial discharge area is controlled through cooperation of the nanometer knife electrode needle and the puncture needle outer sleeve; the puncture needle comprises a coaxial sharp puncture needle and a coaxial blunt puncture needle, and the coaxial sharp puncture needle is adopted when the puncture percutaneously passes through the tissue; the needle passes through the cavity and can be penetrated by a puncture blunt needle, so that the injury to a patient can be reduced.

Description

Technical Field

[0001] The present invention relates to the field of clinical tumor ablation treatment devices, and specifically to a nanoknife for clinical tumor ablation treatment. Background Art

[0002] Tumor ablation treatment technology refers to a precise minimally invasive interventional treatment technology that uses various physical methods such as radiofrequency, microwave, cryotherapy, high-frequency electrocautery, laser, high-energy focused ultrasound, or local injection of absolute ethanol, hot saline, hot distilled water, etc. under the guidance of medical imaging to directly damage tumors. Tumor ablation includes physical ablation and chemical ablation. Chemical ablation mainly refers to injecting various ablation agents into the tumor. Physical ablation includes cryoablation, such as argon-helium knife and liquid nitrogen knife; thermal ablation, such as radiofrequency, microwave, laser, and ultrasound focusing; and normal temperature ablation, such as nanoknife ablation.

[0003] Nanoknife technology releases microsecond-level high-voltage pulses through an ablation probe, breaks through the tumor cell membrane, forms nanoscale irreversible electroporation, and causes apoptosis of target cells (cancer cells). Traditional nanoknives adopt an integrated design of an electrode and an insulating sleeve, and a power cord is connected to the tail of the electrode handheld end. The gravitational effect of the electrode handheld end and the power cord and the pulling effect of the power cord on the electrode during the needle insertion process will affect the needle insertion. Especially under CT guidance, intraoperative scans are frequently required to confirm the position of the electrode, resulting in electrode displacement due to gravity and pulling during the scan after needle insertion, reducing the accuracy of needle insertion. Therefore, a nanoknife for clinical tumor ablation treatment is proposed to address the above problems. Summary of the Invention

[0004] The purpose of the present invention is to provide a nanoknife for clinical tumor ablation treatment to solve the above problems.

[0005] The present invention achieves the above purpose through the following technical solutions. A nanoknife for clinical tumor ablation treatment includes a nanoknife electrode needle and a supporting puncture needle outer sleeve, puncture sharp needle, puncture blunt needle, power supply placement grip tube, Luer connector, and round block. The needle bodies sleeved inside the puncture needle outer sleeve are respectively a nanoknife electrode needle, a puncture sharp needle, and a puncture blunt needle. One end port of the puncture needle outer sleeve is fixedly connected in communication with an interface one on the Luer connector. One end of the nanoknife electrode needle is equipped with a connection cap. The end face of one end of the nanoknife electrode needle inside the connection cap is in close contact with the middle of the end face of a convex screw head on one side of the round block, and the electrical contact point in the middle of the end face of the convex screw head is electrically connected to a power output component inside the power supply placement grip tube. An interface one and an interface two on the Luer connector form a needle body passing channel. Multiple size marking points are distributed on the surface of the puncture needle outer sleeve.

[0006] Preferably, there are three connection caps in total, and two of them are respectively installed at one end of the puncture sharp needle and one end of the puncture blunt needle.

[0007] Preferably, the distance between adjacent dimension marking points is 10 mm, and the distance between two adjacent dimension marking points at one end is 1 mm.

[0008] Preferably, a T-shaped dredging and switching pipe is arranged inside the luer connector, and the middle part of the T-shaped dredging and switching pipe is connected with a modulation knob located in the middle of the side of the luer connector.

[0009] Preferably, the luer connector is further provided with an interface three and an interface four.

[0010] Preferably, a second convex screw head is arranged on the other side of the round block, and a short shaft is installed in the middle of the round block. Both inner sides of the two ends of the short shaft are rotationally connected to the end grooves corresponding to the ends of the power supply storage and holding cylinder through bearings.

[0011] Preferably, the outer end of the short shaft is fixedly connected to the corresponding part on the power supply storage and holding cylinder through a buckle.

[0012] Preferably, a current modulation push-pull member is arranged on the power supply storage and holding cylinder, and a power supply and a current control element are arranged inside the power supply storage and holding cylinder.

[0013] The beneficial effects of the present invention are as follows:

[0014] First, the puncture needle outer sleeve made of a matching insulating material has a small gravity, reducing the influence of gravity and pulling during the needle insertion process, and improving the accuracy of the needle insertion to the target position.

[0015] Second, take out the puncture needle core and retain the puncture needle outer sleeve, which is convenient for the nano-knife electrode needle to enter the tumor position through the puncture needle outer sleeve. After reaching the position, through the cooperation of the nano-knife electrode needle and the puncture needle outer sleeve, the size of the axial discharge area of the electrode is controlled.

[0016] Third, the puncture needle includes a coaxial sharp puncture sharp needle and a coaxial puncture blunt needle. When puncturing through the tissue percutaneously, the coaxial sharp puncture sharp needle is used; when the needle passes through the cavity, the puncture blunt needle can be used to reduce the damage to the patient. Description of the Drawings

[0017] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0018] Figure 1 Schematic diagram of the mating connection structure between the nano knife electrode needle and the puncture needle outer cannula of the present invention;

[0019] Figure 2 Schematic diagram of the mating connection structure between the puncture needle outer cannula and the puncture sharp needle of the present invention;

[0020] Figure 3 Schematic diagram of the mating connection structure between the puncture needle outer cannula and the puncture blunt needle of the present invention;

[0021] Figure 4 Enlarged view of the connection structure between the Luer connector and one end of the puncture needle outer cannula of the present invention;

[0022] Figure 5 Partial enlarged view of the connection structure between the puncture needle outer cannula and the puncture blunt needle of the present invention;

[0023] Figure 6 Schematic diagram of the circular block connection structure of the present invention.

[0024] In the figure: 1, nano knife electrode needle; 2, puncture needle outer cannula; 210, size marking point; 3, puncture sharp needle; 4, puncture blunt needle; 5, Luer connector; 510, modulation knob; 520, interface one; 530, interface two; 540, interface three; 550, interface four; 560, T-shaped dredging switching tube; 6, power supply placement grip tube; 610, end groove; 7, circular block; 710, short axis; 720, convex screw head one; 730, convex screw head two; 8, connection cap; 9, lock; 10, current modulation push-pull member. Detailed implementation manners

[0025] To make the objectives, features, and advantages of the present invention more obvious and understandable, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the embodiments described below are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the scope of protection of the present invention.

[0026] The technical solutions of the present invention will be further described below in conjunction with the accompanying drawings and through specific implementation manners.

[0027] In the description of the present invention, it should be understood that the orientation or positional relationships indicated by the terms "upper", "lower", "top", "bottom", "inner", "outer", etc. are based on the orientation or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation to the present invention.

[0028] Please refer to Figures 1-5 As shown, a nanoknife for clinical tumor ablation treatment includes a nanoknife electrode needle 1 and a puncture needle outer cannula 2, a puncture sharp needle 3, a puncture blunt needle 4, a power supply storage grip cylinder 6, a Luer connector 5 and a round block 7 used in combination. The needle bodies sleeved inside the puncture needle outer cannula 2 are respectively the nanoknife electrode needle 1, the puncture sharp needle 3 and the puncture blunt needle 4. One end port of the puncture needle outer cannula 2 is fixedly connected in communication with an interface one 520 on the Luer connector 5. One end of the nanoknife electrode needle 1 is provided with a connection cap 8. One end face of the nanoknife electrode needle 1 inside the connection cap 8 is in close contact with the electric contact point in the middle of the end face of a first convex screw head 720 on one side of the round block 7. The electric contact point in the middle of the end face of the first convex screw head 720 is electrically connected to a power output component inside the power supply storage grip cylinder 6. A plurality of size marking points 210 are distributed on the surface of the puncture needle outer cannula 2.

[0029] There are three connection caps 8 in total, and two of the connection caps 8 are respectively installed at one end of the puncture sharp needle 3 and one end of the puncture blunt needle 4, which is convenient for installing one end of the puncture sharp needle 3 and one end of the puncture blunt needle 4 on a second convex screw head 730 through the corresponding connection caps 8.

[0030] The distance between adjacent size marking points 210 is 10 mm, and the interval between two adjacent size marking points 210 at one end is 1 mm, which is beneficial for operating to determine the target position of needle insertion.

[0031] As Figure 4 shown, an interface one 520 and an interface two 530 on the Luer connector 5 form a needle body passing channel. A T-shaped dredging switching tube 560 is arranged inside the Luer connector 5, and the middle of the T-shaped dredging switching tube 560 is connected to a modulation knob 510 in the middle of the side of the Luer connector 5. The Luer connector 5 is also provided with an interface three 540 and an interface four 550;

[0032] The tail of the puncture needle outer cannula 2 is designed with a Luer connector 5. During the needle insertion puncture process, the interface four 550 on the side is closed. When the puncture reaches the position, the interface four 550 on the side can be opened to inject chemotherapy drugs. The tail of the puncture needle outer cannula 2 is designed with a controllable and connected T-shaped dredging switching tube 560. By operating the modulation knob 510, the switch of the three-way channel is controlled. When needle insertion puncture is required, the three-way switch is turned to the open position, and the required puncture needle body can be inserted into the puncture needle outer cannula 2 for needle insertion. The sealing cap on the interface four 550 on the side tail can also be opened to inject chemotherapy drugs through this channel; when the needle reaches the target position and the needle is withdrawn, the three-way switch can be turned to the closed position, which can prevent external air from entering the patient's body through the lumen of the puncture needle outer cannula 2 after the needle is withdrawn.

[0033] As Figure 6As shown, a convex screw head 2 730 is provided on the other side of the round block 7, and a short shaft 710 is installed in the middle of the round block 7. The inner sides of both ends of the short shaft 710 are rotatably connected to the end groove 610 located at the corresponding end of the power supply mounting handle 6 through bearings, and the outer end of the short shaft 710 is fixedly connected to the corresponding part on the power supply mounting handle 6 through the lock buckle 9. The round block 7 is installed in a rotating manner and fixed in combination with the lock buckle 9 to achieve the effect of adjusting the position and direction of the convex screw head 1 720 and the convex screw head 2 730.

[0034] Furthermore, a current modulation push-pull member 10 is provided on the power supply mounting handle 6, and a power supply and a current control element are provided inside the power supply mounting handle 6.

[0035] When the present invention is used, after the clinician performs a CT scan and designs the needle path, the puncture needle outer sleeve 2 is first used to perform percutaneous puncture with the puncture sharp needle 3, and the needle tip is moved forward in combination with the size mark point 210 on the puncture needle outer sleeve 2. After each step forward, the handheld end of the puncture sharp needle 3 can be loosened and a CT scan can be performed. Since the self-gravity of the handheld end of the matching puncture sharp needle 3 is much smaller than that of the traditional nano knife electrode handheld end and the wire, and there is no "pulling" effect of the wire, the accuracy of the needle will be greatly improved;

[0036] After the puncture needle reaches the target cancerous area, the nano knife electrode needle 1 is taken out, and the insulating puncture needle outer sheath 2 is left at the patient's puncture site. Then, the nano knife electrode needle 1 is passed through the tail end of the puncture needle outer sheath 2 and moves along the sheath to the cancerous area in the patient's body;

[0037] The thread at the head of the nano knife electrode needle 1 is matched with the Luer connector 5 at the tail end of the nano knife electrode needle 1, and the nano knife electrode needle 1 can be fixed by thread matching; the nano knife electrode needle 1 is operated and moved, and the scale adjustment is performed in combination with the size marking point 210 on the puncture needle outer sleeve 2, so as to cooperate with the puncture needle outer sleeve 2 to achieve the adjustment of the axial discharge length of the electrode in the lesion area in the patient's body;

[0038] The tube head of the matching puncture needle outer cannula 2 adopts a rounded corner design to reduce the damage to the patient's tissues and organs during the needle puncture process. The tail of the puncture needle outer cannula 2 is designed with a Luer connector 5 on the side. During the needle puncture process, the side interface four 550 is closed. When the puncture reaches the target position, the side interface four 550 can be opened to inject chemotherapy drugs. The tail of the puncture needle outer cannula 2 is designed with a T-shaped dredging switching tube 560 with adjustable connection. By operating the modulation knob 510, the switch of the three-way channel is controlled. When needle puncture is required, the three-way switch is turned to the open position, and the required puncture needle body can be inserted into the puncture needle outer cannula 2 for needle puncture. The sealing cap on the side interface four 550 at the tail can also be opened to inject chemotherapy drugs through this channel. After the needle reaches the target position and the needle is withdrawn, the three-way switch can be turned to the closed position, which can prevent external air from entering the patient's body through the lumen of the puncture needle outer cannula 2 after the needle is withdrawn;

[0039] There are black size marks designed outside the needle sheath of the puncture needle outer cannula. The distance between every two adjacent marked points is 10 mm. Starting from the head, two closely adjacent size marks are placed at 50 mm (at the 5th marked point position), and two marks are placed at 100 mm (at the 10th marked point position), and the distance between the two marks is 1 mm;

[0040] During the puncture process, when puncturing through the tissue percutaneously, a puncture sharp needle 3 is used for puncture; when the needle passes through the cavity (such as passing under the peritoneum), a puncture blunt needle 4 can be used for passing, as Figure 5 shown. The puncture blunt needle 4 is more rounded and blunt than the puncture sharp needle 3. It usually does not stimulate blood vessels and nerves, effectively reduces local tissue damage, reduces bruising, reduces the pain of needle puncture, and has a faster postoperative recovery.

[0041] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and without departing from the spirit or basic characteristics of the present invention, the present invention can be implemented in other specific forms. Therefore, from any point of view, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the same elements of the claims are intended to be included in the present invention. Any reference signs in the claims should not be regarded as limiting the claims involved.

[0042] As mentioned above, the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A nano knife for clinical tumor ablation treatment, comprising a nano knife electrode needle (1) and a matching puncture needle outer sleeve (2), a puncture sharp needle (3), a puncture blunt needle (4), a power supply holder (6), a Luer connector (5) and a round block (7), wherein the needle bodies set in the puncture needle outer sleeve (2) are respectively the nano knife electrode needle (1), the puncture sharp needle (3) and the puncture blunt needle (4), and a port at one end of the puncture needle outer sleeve (2) is interconnected and fixedly connected with an interface 1 (520) located on the Luer connector (5), and the nano knife electrode needle (1) is connected to the outer sleeve of the puncture needle. ) is installed at one end with a connecting cap (8), the end face of one end of the nano knife electrode needle (1) located in the connecting cap (8) is in close contact with the electrical contact point in the middle of the end face of the convex screw head (720) located on one side of the round block (7), and the electrical contact point in the middle of the end face of the convex screw head (720) is electrically connected to the power output component located in the power supply holding tube (6), the interface 1 (520) and the interface 2 (530) located on the Luer connector (5) form a needle body passing channel, and the surface of the puncture needle outer sleeve (2) is distributed with a plurality of size marking points (210).

2. The nanoknife for clinical tumor ablation treatment according to claim 1, characterized in that: There are three connecting caps (8) in total, and two of the connecting caps (8) are respectively installed on one end of the sharp puncture needle (3) and one end of the blunt puncture needle (4).

3. The nanoknife for clinical tumor ablation treatment according to claim 1, characterized in that: The spacing between adjacent dimension marking points (210) is 10 mm, and the spacing between two adjacent dimension marking points (210) located at one end is 1 mm.

4. The nanoknife for clinical tumor ablation treatment according to claim 1, characterized in that: A T-shaped dredging switching tube (560) is provided inside the Luer connector (5), and the middle portion of the T-shaped dredging switching tube (560) is connected to the adjustment knob (510) located in the middle portion of the side of the Luer connector (5).

5. The nanoknife for clinical tumor ablation treatment according to claim 1, characterized in that: The Luer connector (5) is also provided with a third interface (540) and a fourth interface (550).

6. The nanoknife for clinical tumor ablation treatment according to claim 1, characterized in that: The other side of the round block (7) is provided with a second convex screw head (730), and a short shaft (710) is installed in the middle of the round block (7). The inner sides of both ends of the short shaft (710) are rotatably connected to the end grooves (610) located at the corresponding ends of the power supply mounting handle (6) through bearings.

7. The nanoknife for clinical tumor ablation treatment according to claim 6, characterized in that: The outer end of the short shaft (710) is fixedly connected to a corresponding position on the power supply mounting handle (6) via a lock buckle (9).

8. The nanoknife for clinical tumor ablation treatment according to claim 1, characterized in that: The power supply mounting handle (6) is provided with a current modulation push-pull component (10), and a power supply and a current control element are provided inside the power supply mounting handle (6).

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