Blood RNA preservation tube

Abstract

The utility model discloses a blood RNA preservation tube which comprises an outer tube body, a placing cylinder, an outer tube cover, an inner tube body and an inner tube cover, a second outer thread groove is formed in the outer side of the top of the outer tube body, a stable base is fixedly installed at the bottom of the placing cylinder, a second inner thread groove is formed in the bottom of an inner cavity of the outer tube cover, and a first inner thread groove is formed in the top of an inner cavity of the inner tube body. Scale marks are arranged on the outer side of the inner tube body. The design of the inner sleeve and the outer sleeve is adopted, the inner sleeve body contains pre-loaded RNA preserving fluid used for directly preserving a blood RNA sample, the outer sleeve body provides a protection function, the stability and the use convenience of RNA preservation are further improved through an independent double-layer sealing structure and an optimized volume design, the outer sleeve body is made of an ultraviolet-proof transparent material, and the service life of the inner sleeve body is prolonged. The inner tube body is designed to be of a small-size structure, a negative pressure environment is arranged, waste of preservation liquid is effectively reduced, and meanwhile the risk of RNA degradation caused by oxygen is reduced.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically a blood RNA preservation tube. Background Technology

[0002] RNA is a biological macromolecule widely distributed in organisms, playing a crucial role in genetic and functional regulation. In medical research, biological experiments, and disease diagnosis, the integrity of RNA samples directly affects the reliability of experimental results. However, due to the 2'-hydroxyl group in its chemical structure, RNA molecules are highly susceptible to degradation by external environmental factors. Therefore, developing high-performance RNA preservation tubes is particularly important for the effective preservation of RNA in blood samples.

[0003] Existing RNA preservation tubes are typically made of a single layer of plastic and filled with RNA preservation solution, which chemically inhibits RNase activity and stabilizes RNA molecules. These tubes offer some antioxidant and sealing properties, providing good short-term protection for RNA samples. However, in practical use, existing RNA preservation tubes still have room for improvement in the following aspects: insufficient UV resistance (RNA preservation tubes are often used in light-exposed environments, and UV radiation can damage the preservation solution or RNA molecules inside, leading to RNA sample degradation); unreasonable volume design (existing RNA preservation tubes typically employ a single-layer, large-volume design, which easily leads to wasted preservation solution when preserving small sample volumes); insufficient stability; and the bottom design of existing RNA preservation tubes is usually rounded, requiring a tube rack for placement, which, especially during experimental operations, can interfere with observing the labels on the preservation tubes and increases the complexity of the operation. Utility Model Content

[0004] The purpose of this invention is to provide a blood RNA preservation tube to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a blood RNA preservation tube, comprising an outer tube body, a placement cylinder, an outer tube cap, an inner tube body, and an inner tube cap. The outer tube body has a second external threaded groove on its outer side at the top. The placement cylinder has a stable base fixedly installed at its bottom. The outer tube cap has a second internal threaded groove at the bottom of its inner cavity. The inner tube body has a first internal threaded groove at the top of its inner cavity. The inner tube body has a scale line on its outer side. The inner tube cap has a first external threaded groove on its outer side at the bottom.

[0006] Preferably, the inner tube is installed inside the outer tube.

[0007] Preferably, the dimensions of the inner thread groove are compatible with those of the outer thread groove, and the inner tube cover and the inner tube body are connected by a threaded seal through the inner thread groove and the outer thread groove.

[0008] Preferably, the dimensions of the second external thread groove are compatible with those of the second internal thread groove, and the outer tube cap and the outer tube body are connected by a threaded seal through the second internal thread groove and the second external thread groove.

[0009] Preferably, the bottom of the outer tube is installed inside the placement cylinder.

[0010] Preferably, a sealing rubber ring one is fixedly installed at the bottom of the inner tube cover, and a sealing rubber ring two is fixedly installed at the top of the inner cavity of the outer tube cover.

[0011] Compared with existing technologies, the advantages of this invention are as follows: By adopting an inner and outer tube design, the inner tube contains pre-filled RNA preservation solution for direct preservation of blood RNA samples, while the outer tube provides protection. Through an independent double-layer sealing structure and optimized volume design, the stability and ease of use of RNA preservation are further improved. The outer tube is made of UV-resistant transparent material, which can block UV damage to RNA while maintaining sample visibility. The inner tube is designed with a small volume structure and a negative pressure environment, effectively reducing the waste of preservation solution and lowering the risk of oxygen degradation of RNA. In addition, a placement tube and a stable base are added to the lower end of the outer tube to enhance the stability of the device during operation and transportation, and to prevent sample leakage or contamination. Attached Figure Description

[0012] Figure 1 This is a three-dimensional structural diagram of the present utility model.

[0013] Figure 2 This is a schematic diagram of the disassembled three-dimensional structure of this utility model.

[0014] Figure 3 This is a schematic diagram of the disassembled, bottom-view structure of this utility model.

[0015] In the diagram: 1. Outer tube; 2. Placement cylinder; 3. Outer tube cover; 4. Stable base; 5. Inner tube; 6. Inner tube cover; 7. External thread groove one; 8. Internal thread groove one; 9. Scale line; 10. External thread groove two; 11. Internal thread groove two; 12. Sealing rubber ring two; 13. Sealing rubber ring one. Detailed Implementation

[0016] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0017] Please see Figures 1-3 This utility model provides a technical solution: a blood RNA preservation tube, comprising an outer tube body 1, a placement cylinder 2, an outer tube cap 3, an inner tube body 5, and an inner tube cap 6. The inner tube body 5 is installed inside the outer tube body 1, and the bottom of the outer tube body 1 is installed inside the placement cylinder 2. An external threaded groove 10 is formed on the outer side of the top of the outer tube body 1. A stable base 4 is fixedly installed at the bottom of the placement cylinder 2. An internal threaded groove 11 is formed at the bottom of the inner cavity of the outer tube cap 3. The specifications and dimensions of the external threaded groove 10 are the same as those of the internal threaded groove 6. The dimensions of groove 21 are compatible, and the outer tube cap 3 and the outer tube body 1 are connected by internal thread groove 211 and external thread groove 20. The top of the inner cavity of the inner tube body 5 is provided with internal thread groove 18, and the outer side of the inner tube body 5 is provided with scale line 9. The outer side of the bottom of the inner tube cap 6 is provided with external thread groove 17. The dimensions of internal thread groove 18 are compatible with the dimensions of external thread groove 17, and the inner tube cap 6 and the inner tube body 5 are connected by internal thread groove 18 and external thread groove 17.

[0018] The working principle of the above technical solution is as follows: The inner tube 5 is a small-volume vacuum tube used to contain blood samples and RNA preservation solution. The material of the inner tube 5 is medical-grade polypropylene or polycarbonate, which has high chemical stability and airtightness. The capacity of the inner tube 5 is designed to be 2mL, suitable for storing small amounts of blood samples. The upper end of the inner tube 5 is connected to the inner tube cap 6 by internal thread groove 8 and external thread groove 7 to ensure airtightness. The outer wall of the inner tube 5 is provided with scale lines 9 to facilitate accurate observation of the sample volume by the operator. The outer tube 1 is made of double-layer UV-resistant material. The outer layer is transparent UV-resistant polycarbonate, and the inner layer is highly transparent medical-grade polypropylene. The volume of the outer tube 1 is adapted to the inner tube. The design features an inner diameter slightly larger than the outer diameter of the inner tube 5, with a 0.5mm gap, facilitating the inclusion of the inner tube 5 and ensuring a tight fit. The top of the outer tube 1 matches the inner and outer tube caps 3, and the connection is sealed by internal thread groove 11 and external thread groove 10, further enhancing the sealing performance. The outer wall of the outer tube 1 has anti-slip textures for easy gripping and operation. The bottom of the placement cylinder 2 is fixed with a stable base 4, made of wear-resistant and anti-slip thermoplastic elastomer, which has good stability and anti-slip properties. The diameter of the stable base 4 is 1.5 times the diameter of the outer tube 1, ensuring that the device is not easily tipped over on the operating table. The placement cylinder 2 is detachable for easy cleaning or replacement.

[0019] In another implementation scheme, such as Figures 1-3 As shown, a sealing rubber ring 13 is fixedly installed at the bottom of the inner tube cover 6, and a sealing rubber ring 2 12 is fixedly installed at the top of the inner cavity of the outer tube cover 3.

[0020] The overall airtightness of the device can be enhanced by setting sealing rubber ring 13 and sealing rubber ring 12.

[0021] Working Principle: The inner tube 5 is a small-volume vacuum tube used to contain blood samples and RNA preservation solution. The inner tube 5 is made of medical-grade polypropylene or polycarbonate, possessing high chemical stability and airtightness. The inner tube 5 is designed with a capacity of 2mL, suitable for storing small amounts of blood samples. The upper end of the inner tube 5 is connected to the inner tube cap 6 via internal thread groove 8 and external thread groove 7 to ensure airtightness. Graduation lines 9 are provided on the outer wall of the inner tube 5 for easy observation of sample volume by the operator. The outer tube 1 is made of double-layered UV-resistant material: an outer layer of transparent UV-resistant polycarbonate and an inner layer of highly transparent medical-grade polypropylene. The volume of the outer tube 1 is adapted to the inner tube design, with its inner diameter slightly larger than the outer diameter of the inner tube 5, with a gap of 0.5μm. The inner tube 5 is easily accommodated and kept in close contact with the outer tube 1. The top of the outer tube 1 matches the inner and outer tube caps 3 and is connected by a threaded seal through the inner thread groove 11 and the outer thread groove 10, further enhancing the sealing performance. The outer wall of the outer tube 1 is provided with anti-slip texture, making it easy for operators to hold and operate. The bottom of the placement cylinder 2 is fixed with a stable base 4. The stable base 4 is made of wear-resistant and anti-slip thermoplastic elastomer, which has good stability and anti-slip properties. The diameter of the stable base 4 is 1.5 times the diameter of the outer tube 1, ensuring that the device is not easy to tip over on the operating table. The placement cylinder 2 is detachable for easy cleaning or replacement. The sealing rubber rings 13 and 12 enhance the overall airtightness of the device.

[0022] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A blood RNA preservation tube, comprising an outer tube body (1), a placement tube (2), an outer tube cap (3), an inner tube body (5), and an inner tube cap (6), characterized in that: The outer tube (1) has an external threaded groove 2 (10) on the outer side of the top. The bottom of the placement cylinder (2) is fixedly installed with a stable base (4). The bottom of the inner cavity of the outer tube cover (3) has an internal threaded groove 2 (11). The top of the inner cavity of the inner tube (5) has an internal threaded groove 1 (8). The outer side of the inner tube (5) is provided with a scale line (9). The outer side of the bottom of the inner tube cover (6) has an external threaded groove 1 (7).

2. The blood RNA preservation tube according to claim 1, characterized in that: The inner tube (5) is installed inside the outer tube (1).

3. A blood RNA preservation tube according to claim 2, characterized in that: The dimensions of the inner thread groove (8) are compatible with those of the outer thread groove (7), and the inner tube cover (6) and the inner tube body (5) are connected by the thread seal of the inner thread groove (8) and the outer thread groove (7).

4. A blood RNA preservation tube according to claim 3, characterized in that: The dimensions of the external thread groove 2 (10) are compatible with those of the internal thread groove 2 (11), and the outer tube cover (3) and the outer tube body (1) are connected by the internal thread groove 2 (11) and the external thread groove 2 (10) through threaded sealing.

5. A blood RNA preservation tube according to claim 4, characterized in that: The bottom of the outer tube (1) is installed inside the placement tube (2).

6. A blood RNA preservation tube according to claim 5, characterized in that: A sealing rubber ring one (13) is fixedly installed at the bottom of the inner tube cover (6), and a sealing rubber ring two (12) is fixedly installed at the top of the inner cavity of the outer tube cover (3).

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