Oligopeptide gel carrier structure for periodontal recovery as well as preparation method and application of oligopeptide gel carrier structure

Abstract

The invention relates to the technical field of medicine gel, and discloses an oligopeptide gel carrier structure for periodontal recovery, which comprises a gel matrix, a linear micro-channel is arranged in the gel matrix, a plurality of layers of oral soluble films are arranged in the linear micro-channel, the oral soluble films can be dissolved by saliva, the oral soluble films divide the linear micro-channel into a plurality of medicine carrying areas, and the medicine carrying areas are arranged in the linear micro-channel. An antibacterial medicine is placed in the medicine carrying area; when the gel matrix is continuously chewed by teeth, saliva can be sucked into the linear micro-channel, the oral dissolving film is sequentially dissolved to enable the medicine carrying areas to be sequentially opened, and the antibacterial medicine in the linear micro-channel is continuously released into the oral cavity along with flowing of the saliva; the invention also discloses a preparation method and application thereof. According to the invention, sustainable release of the medicine is realized, and the acting time of the medicine on bacterial colonies is prolonged, so that the bacterial colonies at the gingival position can be sterilized, and meanwhile, excessively secreted oral saliva can be utilized without being influenced by the saliva secretion amount.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical gels, and particularly to an oligopeptide gel carrier structure for periodontal restoration, its preparation method and application. Background Art

[0002] Dental implants are a key technology for solving tooth loss caused by various factors. However, when the external environment changes and exceeds the buffering capacity of the microbial system, it can cause oral microecological disorders. Some originally healthy microorganisms may become conditional pathogenic microorganisms, thus triggering infectious diseases such as dental caries and periodontal diseases. Especially for some patients with underlying diseases, preliminary clinical observations have shown that type 2 diabetes does change the composition of the subgingival microbial flora around dental implants after implantation. The proportions of cocci and bacilli will gradually increase over time, leading to frequent gingival inflammation.

[0003] In order to be able to anti - inflame the oral environment, there are many types of drugs on the market currently. For example, the application of a compound traditional Chinese medicine extract in the preparation of oral care health products (publication number: CN103520049A) discloses that the traditional Chinese medicine extract is added as an auxiliary drug raw material with anti - inflammatory and hemostatic effects to oral care health products, and the application of these four traditional Chinese medicine extracts in oral care products such as toothpaste, mouthwash, tooth powder, throat lozenges, chewing gum, etc. However, the above drugs have the defect that the adhesion time and concentration of the drug are insufficient during actual use.

[0004] In fact, during the specific sterilization process, if the sterilization time is short or the collision rate between the drug and the microbial flora is insufficient, it may lead to the generation of drug resistance in the microbial flora, making it more difficult to eliminate the colonies. For example, cleaning agents such as toothpaste, mouthwash, and tooth powder have a short adhesion time, and long - term use will cause excessive tooth cleaning; for example, medicated agents such as throat lozenges, chewing gum, and gels, although they can administer drugs targeted, it is difficult to control the drug administration time, and the drug release situation is difficult to predict. As the patient's oral cavity secretes a large amount of saliva, the drug concentration is continuously diluted, resulting in a decline in the killing ability of the entire microbial flora.

[0005] In addition, for current market products, they mainly tend to sterilize the oral environment. For another aspect of periodontal restoration, such as periodontal regeneration, less consideration is given. Moreover, even if there is, the consideration of periodontal regeneration, periodontal inflammation, sterilization, etc. is independent, and it is rare to consider the above two aspects simultaneously on the same carrier structure. Further, no discovery has been made on jointly promoting periodontal restoration based on the interaction between the two. Summary of the Invention

[0006] The purpose of the present invention is to provide an oligopeptide gel carrier structure for periodontal restoration, a preparation method and an application thereof, so as to solve the technical problems in the prior art of short administration time, great influence by saliva and insufficient consideration of synergistic effects.

[0007] In order to solve the above technical problems, the present invention specifically provides the following technical solutions: The present invention provides an oligopeptide gel carrier structure for periodontal restoration, comprising a gel matrix, wherein the oligopeptides are uniformly distributed in the gel matrix, a plurality of linear microchannels are formed in the gel matrix, and each of the linear microchannels is divided into a plurality of drug-loading areas by a plurality of orally soluble films arranged in parallel, wherein the plurality of drug-loading areas are sequentially arranged from the inside to the outside in the linear microchannel, and each of the drug-loading areas is filled with antibacterial drugs; The orodispersible film can be dissolved by saliva and has toughness. When the gel matrix is ​​continuously chewed by teeth, saliva can be sucked into the linear microchannel. The orodispersible film dissolves in sequence so that the drug-loading areas are opened in sequence. As saliva flows, the antibacterial drugs in the linear microchannel are continuously released into the oral cavity.

[0008] As a preferred embodiment of the present invention, the gel matrix is ​​composed of gelatin, and the gelatin contains oligopeptides evenly distributed therein, wherein the oligopeptides form an oligopeptide self-assembly network structure in the gelatin.

[0009] As a preferred embodiment of the present invention, the maximum radius of the linear microchannel is 0.5-1.0 mm, and wrinkles are provided on the inner surface of the linear microchannel; The antibacterial drug is chlorhexidine or metronidazole.

[0010] The present invention also provides a method for preparing an oligopeptide gel carrier structure for periodontal restoration, comprising the following steps: S100, selecting a gel matrix, liquefying the gel matrix, adding oligopeptides after liquefaction, and forming an oligopeptide self-assembly network structure in the gel matrix after sufficient mixing to obtain a gel prefabricated block; S200, punching the gel prefabricated block by air jetting to form a plurality of linear microchannels penetrating the gel prefabricated block in the gel prefabricated block; S300, injecting the antibacterial drug and the orodissolving material into the linear microchannel in sequence to form a group of drug-loading areas wrapped by the orodissolving film, repeating the previous step multiple times to form multiple groups of drug-loading areas arranged sequentially from the inside to the outside in the linear microchannel, wherein after the orodissolving material is injected, it needs to expand under the action of its surface tension and contact with the inner wall of the linear microchannel to solidify before proceeding to the next step; S400, repeating step S300 for each linear microchannel to prepare a drug gel.

[0011] As a preferred embodiment of the present invention, the gel matrix is a gelatin gel with an agar content of 0.

[0012] As a preferred embodiment of the present invention, the specific manner in which the oligopeptide forms an oligopeptide self-assembled network structure within the gel matrix includes the construction of amelogenin amphiphilic oligopeptides and the preparation of an amelogenin amphiphilic oligopeptide biological scaffold; Among them: The construction of amelogenin amphiphilic oligopeptides includes the following steps: Introduce an RGD (Arg-Gly-Asp) sequence with cell adhesion characteristics at the end of the oligopeptide sequence to enhance the adhesion of seed cells to the amelogenin oligopeptide scaffold; Synthesize and purify amelogenin amphiphilic oligopeptides using solid-phase synthesis; After drying, crush to form oligopeptide powder; The preparation of the amelogenin amphiphilic oligopeptide biological scaffold includes the following steps: ① Take a quantitative amount of oligopeptide powder and dissolve it in NaOH solution, and obtain an oligopeptide solution through ultrasonic dissolution; ② Dropwise add CaCl2 solution to the oligopeptide solution, shake well, observe the self-assembly of the oligopeptide, and continue shaking until the oligopeptide solution forms a flocculent suspension.

[0013] As a preferred embodiment of the present invention, in the S200, the air injection method is to inject an air bullet ejected by a high-pressure gas injection device into the gel preform, so as to form an air cavity in the gel preform to form a linear microchannel; Among them, in the linear microchannel, the radius of the air bullet inlet is larger than the radius of the air bullet outlet.

[0014] As a preferred embodiment of the present invention, the inner wall of the linear microchannel is rough; The internal roughness of the linear microchannel is determined by the air flow velocity of the air injection method. The smaller the air flow velocity of the air injection method, the greater the roughness; When the air flow ejected by the air injection method cannot penetrate the gel preform at one time, inject the air flow in the same direction again or inject it in the opposite direction from the outlet direction of the linear microchannel.

[0015] The present invention also provides an application of the oligopeptide gel carrier structure for periodontal restoration, and the application form is a drug gel. Among them, periodontal restoration includes periodontal inflammation recovery and periodontal regeneration.

[0016] As a preferred embodiment of the present invention, the application method is specifically: Set the corresponding chewing unit time according to the specifications of the drug gel; Put the drug gel directly into the mouth and chew. During the chewing unit time, saliva wraps the drug gel, and oligopeptides gradually precipitate from the gelatin and enter the oral cavity environment along with the saliva; During chewing, saliva slowly erodes the orally disintegrating film in sequence, so that the antibacterial drugs in the drug gel are slowly released in sequence, so as to maintain the concentration of the antibacterial drugs in the oral cavity during the chewing unit time and keep the sterilization continuous.

[0017] The present invention has the following beneficial effects compared with the prior art: In the present invention, both oligopeptides and antibacterial drugs use a gel matrix as a carrier structure and are continuously released along with chewing after entering the oral cavity. For the former, it can avoid concentrated release, concentrated sedimentation and adsorption. For the latter, it can ensure the drug concentration for a long time to maintain the bactericidal effect. At the same time, the oligopeptides with an oligopeptide self-assembled network structure can extend the chewiness of the gel matrix and can play a further sustained release role.

[0018] During the whole treatment process, the interaction between antibacterial and regeneration can be taken into account simultaneously to improve the effect of periodontal recovery.

[0019] Among them, the oligopeptides are first stored in the gel matrix in a flocculent form, and cavities are formed in the chew-resistant gel matrix, and multiple layers of orally disintegrating materials and antibacterial drugs are intermittently stuffed into the linear microchannels. When the gel matrix is continuously chewed by teeth, saliva wraps the gel matrix and can be inhaled into the linear microchannels, and releases the oligopeptide components and dissolves the orally disintegrating materials in sequence, realizing the sustainable release of the drugs, prolonging the action time of the drugs on the colonies, so as to be able to sterilize the colonies at the gum position, and at the same time can utilize the excessively secreted oral saliva without being affected by the saliva secretion volume; The dissolution time of the drug of the present invention is controlled by the thickness, number of layers and diameter of the multiple layers of orally disintegrating materials and antibacterial drugs. The sustained release time is long, the sterilization effect is good, and by changing the thickness, number of layers, type and diameter of the multiple layers of orally disintegrating materials and antibacterial drugs, the targeted elimination of various colonies can be realized, and the adaptability is wide. Brief Description of the Drawings

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only exemplary, and for those of ordinary skill in the art, other implementation drawings can be obtained according to the provided drawings without creative labor.

[0021] Figure 1 It is a schematic structural diagram of the drug gel provided by the present invention for periodontal inflammation recovery; Figure 2Provided for the present invention Figure 1 Schematic diagram of the internal structure of the linear microchannel in the illustrated embodiment; Figure 3 Provided for the present invention is a flowchart of a preparation method of a drug gel for periodontal inflammation recovery.

[0022] The reference numerals in the figure respectively represent the following: 1 - gel matrix; 2 - linear microchannel; 3 - orally dissolving film; 4 - drug-loading area. Specific embodiments

[0023] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0024] In the present invention, periodontal restoration includes periodontal inflammation recovery and periodontal regeneration. Among them, periodontal inflammation recovery mainly depends on the continuous and slow release of antibacterial drugs so that the drug concentration can be maintained within the designed range for a long time; periodontal regeneration mainly depends on the action of the oligopeptide gel.

[0025] In the objects studied in the present invention, periodontal inflammation recovery and periodontal regeneration are mostly accompanied by each other. Therefore, in order to improve the treatment effect and utilize the interaction between antibacterial and regeneration to improve the effect of periodontal recovery, it is necessary to use a unified carrier to take into account the recovery effects of both aspects.

[0026] As Figures 1 to 2 shown, the present invention provides an oligopeptide gel carrier structure for periodontal recovery, including a gel matrix 1 with relatively high hardness. This gel matrix 1 is a chew-resistant gel. Among them, the main component of the gel matrix 1 can be composed of gelatin gel, or can be composed of other soft but not easily crushed composite gels. Another part of the component is mainly amelogenin amphiphilic oligopeptide.

[0027] In this embodiment, the main component is considered to be gelatin, mainly because the cost of gelatin gel is relatively low, which is easy to reduce the cost of the entire drug gel.

[0028] Particularly, the drug in this gel matrix 1 is attached in a cavity with a specific spatial structure. The linear microchannel 2 is embedded in the gel matrix 1. Several layers of orally dissolving films 3 are arranged in the linear microchannel 2. The orally dissolving film 3 is a material that can be dissolved by saliva and melts after contacting human saliva. It is also a new type of existing drug delivery material. Among them, the orally dissolving film 3 divides the linear microchannel 2 into several drug-loading areas 4, and antibacterial drugs are placed in the drug-loading areas 4.

[0029] When in use, in the direction in which the linear microchannel 2 extends, avoiding the linear microchannel 2, cut this gel matrix 1 into palatable small pieces. The user holds the small pieces in the mouth and slowly chews this gel matrix 1 with teeth. When this gel matrix 1 is continuously chewed by teeth, saliva can be inhaled into the linear microchannel 2, the oral soluble film 3 is broken successively, so that the drug-loading area 4 is opened successively, and with the flow of saliva, the antibacterial drug in the linear microchannel 2 is continuously released into the oral cavity.

[0030] Specifically, the oral soluble film 3 located on the outer layer is first dissolved, and saliva enters the drug-loading area 4. The antibacterial drug blocks the entry of saliva. With continuous chewing, the antibacterial drug and saliva flow out of the linear microchannel 2, and the antibacterial drug is released in the patient's oral cavity and can be specifically released at the chewing site. When the amount of the antibacterial drug in this layer of drug-loading area 4 is not enough to block the entry of saliva, saliva containing sufficient salivary amylase further dissolves the oral soluble film 3 located in the lower layer, and the above steps are repeated.

[0031] Among them, the user holding the gel in the mouth can, to a certain extent, realize the flow of saliva, but basically relies on chewing to drive saliva to be deeply inhaled into the linear microchannel 2. With continuous chewing of the patient, the drug can be continuously released, maintaining the concentration of the antibacterial agent at the chewing site. Moreover, the release of the drug deep inside requires the oral soluble film and the antibacterial drug to be dissolved successively, with a long release time, realizing the sustainable release of the drug, achieving the effect of drug slow release, and prolonging the action time of the drug on the colonies, so as to be able to sterilize the colonies at the gum position.

[0032] Furthermore, during the chewing process, the cleaning of the patient's teeth can also be realized.

[0033] It should be noted that this drug gel is a chewing type and cannot be widely applied to multiple anti-inflammatory fields. It is not applicable to the early stage of anti-inflammatory for tooth extraction and dental implantation. This drug gel is mainly aimed at improving the oral flora, realizing the controllable release of the drug during the chewing process, and can utilize the excessively secreted oral saliva. The flow of saliva in the oral cavity drives the release of the drug.

[0034] The antibacterial drug can be chlorhexidine, amoxicillin, penicillin, chloramphenicol, erythromycin, metronidazole, clindamycin, oxacillin, etc.

[0035] In this gel matrix 1, the maximum radius of the linear microchannel 2 is not greater than 1.0 mm, and at the same time, in order to facilitate the establishment of the drug-loading area 4, the minimum radius is not less than 0.5 mm.

[0036] As Figure 3 shown, the present invention further provides a preparation method for an oligopeptide gel carrier structure for periodontal restoration, including the following steps: S100. Select a gel matrix, liquefy the gel matrix, add oligopeptides after liquefaction, and form an oligopeptide self-assembly network structure in the gel matrix after sufficient mixing to obtain a gel preform. S200. Punch holes in the gel preform by air injection method so that several linear microchannels are formed in the gel preform. In the linear microchannels, the radius of the air bullet inlet is larger than the radius of the air bullet outlet, and the radius of the air bullet inlet can be within the range of 0.5 - 1.0 mm. S300. Use a thin tube to inject an antibacterial drug and an orally dissolving material into the linear microchannels in sequence, so that the orally dissolving material forms a sealed orally dissolving film in the linear microchannels, and repeat multiple times to obtain a drug gel. S400. Store the drug gel in a sealed manner.

[0037] Preferably, in order to prevent the gel from being quickly chewed into pieces, the gel matrix can be selected as gelatin gel with 0 agar content, or the hardness of the gelatin can be further increased by heating, and its preparation is mainly based on the comfort of the patient's use.

[0038] In this embodiment, the oligopeptide self-assembly network structure composed of oligopeptides needs to be further explained. This oligopeptide self-assembly network structure does not form a "scaffold" with a solid structure, but is equivalent to adding an aggregate (in this embodiment, the aggregate is the floc formed after the dissolution of oligopeptide powder) to facilitate the shaping of the gel matrix, thus playing the role of a "scaffold", and its principle is similar to adding stone as an aggregate in mortar to form concrete.

[0039] In the above, the specific method for the oligopeptide to form an oligopeptide self-assembly network structure in the gel matrix includes the construction of amelogenin amphiphilic oligopeptide and the preparation of amelogenin amphiphilic oligopeptide biological scaffold.

[0040] Among them: The construction of amelogenin amphiphilic oligopeptide includes the following steps: Introduce an RGD (Arg - Gly - Asp) sequence with cell adhesion characteristics at the end of the oligopeptide sequence to enhance the adhesion of seed cells to the amelogenin oligopeptide scaffold. Synthesize and purify amelogenin amphiphilic oligopeptide by solid-phase synthesis method. Dry and crush to form oligopeptide powder. The preparation of amelogenin amphiphilic oligopeptide biological scaffold includes the following steps: ① Take a quantitative amount of oligopeptide powder and dissolve it in NaOH solution, and obtain an oligopeptide solution by ultrasonic dissolution promotion. ② Dropwise add CaCl2 solution to the oligopeptide solution, shake well, observe the self-assembly of oligopeptides, and continue to shake until the oligopeptide solution forms a flocculent suspension.

[0041] In the above steps, after obtaining the suspension, the suspension is added to the gel matrix after the gel matrix is ​​liquefied and mixed sufficiently to disperse the suspension in the gel matrix.

[0042] The air injection method uses a high-pressure gas injection device to inject air into the gel preformed block, so that an air cavity, i.e., a linear microchannel, is formed in the gel preformed block. During the process of air entering, the inner wall of the linear microchannel is rough, which facilitates the adhesion of the antibacterial drug and the orosoluble film material.

[0043] Compared with other cavity creation methods, the air jet method disclosed in the present invention can adapt to a relatively soft gel matrix 1, and can create a cavity that is wide on the outside and narrow on the inside in the gel matrix 1, thereby reducing the entry speed of saliva, prolonging the sustained release time, and has high cavity creation efficiency, and can obtain multiple air cavities at the same time.

[0044] How to use the drug gel: Open the sealed box of the whole gel and take out the drug gel block of appropriate size; Place the drug gel in the mouth and chew it continuously or indirectly for a unit time; During chewing, saliva enters the drug gel, causing the antibacterial drugs in the drug gel to be slowly released, thereby maintaining the concentration of antibacterial drugs in the oral cavity per unit time and keeping the sterilization process going.

[0045] Different bacterial species require different sterilization times, but the specific unit time is related to the radius of the linear microchannel and the number of layers of the drug-loading area 4. Therefore, the chewing time can be adjusted by changing the radius of the linear microchannel and the number of layers of the drug-loading area 4, so as to adapt to a variety of bacterial colonies and have a wide adaptability.

[0046] This gel can also be used for drug sensitivity testing, selecting appropriate antibiotics for targeted and precise intervention, greatly improving the success rate of implant surgery for diabetic patients, and helping to establish a sequential precision dental implant treatment plan for diabetic patients, reducing the risk of implant failure and repeated surgical treatment, improving the quality of life, and reducing medical expenses. At a time when aging is developing rapidly, its social and economic significance is equally significant.

[0047] Similar to the above, in this embodiment, the gel matrix serves as a carrier, which cannot restrict the release of the oligopeptides, but it can delay their release rate. The oligopeptides that have formed a flocculent oligopeptide self-assembled network structure suspension are still in a flocculent form after being released from the gel matrix. During the chewing process, part of the flocculent structure will detach from the gel matrix and be adsorbed in the mouth. The part that has not fallen off will be continuously released during subsequent chewing, avoiding the concentrated release of the adhesive oligopeptide components, which will be concentratedly deposited or adsorbed in a certain part, affecting the overall recovery effect of the oral cavity.

[0048] The above embodiments are only exemplary embodiments of the present application and are not used to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art can make various modifications or equivalent replacements within the essence and protection scope of the present application, and such modifications or equivalent replacements should also be regarded as falling within the protection scope of the present application.

Claims

1. An oligopeptide gel carrier structure for periodontal restoration, characterized in that, It includes a gel matrix (1), in which oligopeptides are evenly distributed, multiple linear microchannels (2) are formed in the gel matrix (1), and each of the linear microchannels (2) is divided into multiple drug-loading areas (4) by multiple layers of orally dissolving films (3) arranged side by side. The multiple drug-loading areas (4) are sequentially arranged from the inside to the outside in the linear microchannel (2), and antibacterial drugs are filled in each of the drug-loading areas (4). The orally dissolving film (3) can be dissolved by saliva and has toughness. When the gel matrix (1) is continuously chewed by teeth, saliva can be inhaled into the linear microchannel (2), and the orally dissolving film (3) is dissolved in turn so that the drug-loading areas (4) are opened in turn. With the flow of saliva, the antibacterial drugs in the linear microchannel (2) are continuously released into the oral cavity.

2. The oligopeptide gel carrier structure for periodontal restoration according to claim 1, characterized in that, The gel matrix (1) is composed of gelatin, and oligopeptides are evenly distributed in the gelatin. Among them, the oligopeptides form an oligopeptide self-assembled network structure in the gelatin.

3. The oligopeptide gel carrier structure for periodontal restoration according to claim 1, characterized in that, The maximum radius of the linear microchannel (2) is 0.5 - 1.0 mm, and wrinkles are provided on the inner surface of the linear microchannel (2). The antibacterial drug is chlorhexidine or metronidazole.

4. A method for preparing an oligopeptide gel carrier structure for periodontal restoration according to any one of claims 1 - 3, characterized in that, It includes the following steps: S100: Select a gel matrix, liquefy the gel matrix, add oligopeptides after liquefaction, and form an oligopeptide self-assembled network structure in the gel matrix after sufficient mixing to obtain a gel preform. S200: Punch holes in the gel preform by an air injection method so that a number of linear microchannels penetrating the gel preform are formed in the gel preform. S300: Inject antibacterial drugs and orally dissolving materials into the linear microchannels in turn to form a group of drug-loading areas wrapped by orally dissolving films. Repeat the above steps multiple times to form multiple groups of drug-loading areas sequentially arranged from the inside to the outside in the linear microchannel. Among them, after injecting the orally dissolving material, it needs to expand under the action of its surface tension and contact and solidify with the inner wall of the linear microchannel before proceeding to the next step. S400: Repeat step S300 for each linear microchannel to obtain a drug gel.

5. The method for preparing an oligopeptide gel carrier structure for periodontal restoration according to claim 4, characterized in that, The gel matrix is a gelatin gel with an agar content of 0.

6. The method for preparing an oligopeptide gel carrier structure for periodontal restoration according to claim 4, characterized in that, The specific way for oligopeptides to form an oligopeptide self-assembled network structure in the gel matrix includes the construction of amelogenin amphiphilic oligopeptides and the preparation of amelogenin amphiphilic oligopeptide biological scaffolds. Among them: The construction of amelogenin amphiphilic oligopeptides includes the following steps: Introduce an RGD (Arg-Gly-Asp) sequence with cell adhesion characteristics at the end of the oligopeptide sequence to enhance the adhesion of seed cells to the amelogenin oligopeptide scaffold. Synthesize and purify amelogenin amphiphilic oligopeptides by solid-phase synthesis method. Crush after drying to form oligopeptide powder. The preparation of amelogenin amphiphilic oligopeptide biological scaffolds includes the following steps: ① Take a certain amount of oligopeptide powder and dissolve it in NaOH solution, and obtain an oligopeptide solution by ultrasonic dissolution promotion. ② Dropwise add CaCl2 solution into the oligopeptide solution, shake well, observe the self-assembly of oligopeptides, and continue to shake until the oligopeptide solution forms a flocculent suspension.

7. The method for preparing an oligopeptide gel carrier structure for periodontal restoration according to claim 4, characterized in that, In the S200, the air injection method is to inject an air bullet ejected by a high-pressure gas injection device into the gel preform, so as to form an air cavity in the gel preform to form a linear microchannel; Among them, in the linear microchannel, the radius of the air bullet inlet is larger than the radius of the air bullet outlet.

8. The method for preparing an oligopeptide gel carrier structure for periodontal restoration according to claim 7, characterized in that, The inner wall of the linear microchannel is rough; The internal roughness of the linear microchannel depends on the air flow velocity of the air injection method. The smaller the air flow velocity of the air injection method, the greater the roughness; When the air flow ejected by the air injection method cannot penetrate the gel preform at one time, the air flow is ejected again in the same direction or in the reverse direction from the outlet direction of the linear microchannel.

9. An application of an oligopeptide gel carrier structure for periodontal restoration according to any one of claims 1 - 3, characterized in that, The application form is a drug gel. Among them, periodontal restoration includes periodontal inflammation restoration and periodontal regeneration.

10. The application according to claim 9, wherein, The application method is specifically as follows: According to the different specifications of the drug gel, the corresponding chewing unit time is set; Put the drug gel directly into the mouth and chew; During the chewing unit time, the drug gel is wrapped by saliva, and the oligopeptide gradually precipitates from the gelatin and enters the oral environment along with the saliva; And during chewing, the saliva slowly erodes the orally disintegrating film in sequence so that the antibacterial drugs in the drug gel are slowly released in sequence, so as to maintain the concentration of the antibacterial drugs in the oral cavity during the chewing unit time and keep the sterilization ongoing.

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