Soft silicone foam dressing and production method thereof

Abstract

The invention discloses a soft silicone foam dressing and a production method thereof, and belongs to the technical field of binding dressings. The invention discloses a soft silicone foam dressing and a production method thereof. According to the formula, medical grade soft polysilicone, a plasticizer (trimethylsilane), a cross-linking agent (vinyl trimethoxy silane), a functionalized silver-silane compound, a liquid absorbent (super absorbent resin), a reinforcing agent (polytetrafluoroethylene), a self-adhesive agent (medical acrylate), a preservative (methylisothiazolinone) and a chemical foaming agent (carbon dioxide) are adopted. And a uniform porous structure is formed through mild reaction and chemical foaming. The dressing is soft, comfortable, good in breathability, super-strong in liquid absorption, excellent in antibacterial property and mechanical property, capable of effectively promoting wound healing and preventing infection, and convenient to use and produce on a large scale. The traditional Chinese medicine composition is simple in formula process, low in cost and extremely high in clinical applicability.

Description

Technical Field

[0001] The present invention relates to the technical field of dressing materials, and more specifically, to a soft silicone foam dressing and a production method thereof. Background Art

[0002] As a new type of wound dressing, soft silicone foam dressings are widely used in the medical field, especially in wound care, burn treatment, and postoperative wound healing. Their main advantages are that the materials are soft and breathable, can effectively maintain a moist environment for the wound, and are conducive to promoting healing. However, traditional soft silicone foam dressings usually have several deficiencies, such as poor antibacterial performance, possible infection problems after use, and low mechanical strength.

[0003] With the increasing demand for wound care, researchers have gradually added functional components to soft silicone foam dressings to improve their performance. For example, the introduction of functionalized silver-silane composites as antibacterial agents has given the dressings significant advantages in resisting bacterial infections. The role of silver ions in antibacterial therapy has been widely recognized, and after binding with silane, it can not only increase the antibacterial effect but also improve its binding strength with silica gel, improving the stability and durability of the material.

[0004] Most of the soft silicone foam dressings on the current market already have basic wound care functions, but there are still problems such as insufficient anti-infection effect and limited liquid absorption. In order to better meet the clinical needs, the development of new functionalized soft silicone foam dressings has become a research hotspot. Combining various functional components such as plasticizers, cross-linking agents, liquid absorbents, and reinforcing agents can not only improve the softness, adhesiveness, water absorption of the dressings but also further enhance their antibacterial effect and comfort, thereby providing more comprehensive support for wound healing.

[0005] In the future, with the continuous development of materials science and biomedical technology, the functionalization direction of soft silicone foam dressings will become more and more refined. More intelligent dressings may automatically release antibacterial drugs or other components that promote healing according to the specific situation of the wound and become part of personalized treatment. In addition, with the increasing emphasis on green and environmentally friendly materials, the development of degradable silane-based materials and harmless chemical components will also become a major trend in future development. Summary of the Invention

[0006] The purpose of the present invention is to provide a soft silicone foam dressing and a production method thereof, which are soft and comfortable, have good air permeability, strong liquid absorption, excellent antibacterial and mechanical properties, and have a simple process and are easy to promote.

[0007] A soft silicone foam dressing and its production method, characterized in that: a soft silicone foam dressing and its production method, adding 50% of medical-grade soft silicone base liquid into a clean reaction kettle, heating the temperature to 60 - 80 °C, adding 2 - 4% of plasticizer, stirring for 3 - 7 minutes at a temperature of 60 - 80 °C, under the condition of continuous stirring, slowly adding 2 - 4% of crosslinking agent, continuing to stir for about 8 - 12 minutes, slowly adding 1 - 3% of functionalized silver-silane complex, continuing to stir for about 8 - 12 minutes, slowly adding 8 - 12% of pre-uniformly dispersed liquid absorbent and 4 - 8% of pre-uniformly dispersed air permeability enhancer, low-shear stirring for 8 - 12 minutes, then adding 6 - 10% of self-adhesive and 0.6 - 1% of preservative, continuing gentle stirring for 8 - 12 minutes, then adding 3 - 5% of chemical foaming agent for foaming, adjusting the stirring speed to medium, lasting for 6 - 10 minutes, controlling the temperature at 70 - 74 °C, quickly pouring the foaming liquid into a pre-prepared mold, standing at room temperature for 10 - 15 minutes to make the preliminary foam structure stably formed, transferring the mold to an oven, curing at 80 - 100 °C for 2 - 3 h, then naturally cooling to room temperature, trimming and then performing high-pressure steam sterilization treatment, and packaging in a sterile operation room to obtain the product.

[0008] Preferably, the plasticizer is trimethylsilane.

[0009] Preferably, the crosslinking agent is vinyltrimethoxysilane.

[0010] Preferably, the preparation method of the functionalized silver-silane complex: adding 50 mL of ethanol and 10 mmol of 3-aminopropyltriethoxysilane into a reaction kettle, magnetically stirring and dispersing evenly, dissolving 0.8 - 1.2 mmol of silver nitrate with 5 mL of ethanol, ultrasonic dispersing evenly, slowly dropping the obtained uniformly dispersed silver nitrate solution into the 3-aminopropyltriethoxysilane solution, while continuously magnetically stirring, continuing to stir for 30 minutes after dropping, under the condition of magnetic stirring, dropwise adding 0.6 - 0.8 mL of deionized water, then using dilute hydrochloric acid (0.1 mol / L) to adjust the solution pH to 4 - 5, heating to 40 - 60 °C, continuing to stir for 1 - 2 h and then naturally cooling to room temperature, filtering the mixed solution through a vacuum filtration device, collecting the precipitate or gel-like substance, placing the filtered product in a vacuum drying oven, drying at 30 - 50 °C for 6 - 10 h until the solvent is completely removed to obtain the dried functionalized silver-silane complex powder.

[0011] Preferably, the liquid absorbent is superabsorbent resin.

[0012] Preferably, the air permeability enhancer is polytetrafluoroethylene.

[0013] Preferably, the self-adhesive is medical acrylate.

[0014] Preferably, the preservative is methylisothiazolinone.

[0015] Preferably, the chemical blowing agent is carbon dioxide.

[0016] Compared with the prior art, the advantages of the present invention are as follows: (1) In the present invention, medical-grade soft silicone is used as the base material, endowing the dressing with the characteristics of softness, good compliance, and high comfort. It can closely adhere to the skin, reducing discomfort caused by friction; the addition of a plasticizer (trimethylsilane) improves the flexibility and ductility of the material, making the product not easily break during repeated bending and long-term use; the use of a crosslinking agent (vinyltrimethoxysilane) promotes the uniform crosslinking of the silicone network, enhancing the stability and durability of the overall structure.

[0017] (2) In the present invention, the functionalized silver-silane complex is formed through the coordination reaction of 3-aminopropyltriethoxysilane with silver ions (Ag⁺), which can effectively release silver ions and exert a broad-spectrum antibacterial effect to prevent wound infection; the addition of a preservative (methylisothiazolinone) further inhibits the growth of microorganisms, ensuring that the dressing does not deteriorate during storage and use.

[0018] (3) In the present invention, the liquid absorbent (superabsorbent resin) has extremely high liquid absorption capacity, can quickly absorb exudate, keep the wound area moist, reduce the risk of infection, and improve the wound healing environment; the application of a chemical blowing agent (carbon dioxide) forms a uniform foam structure, which not only increases the air permeability of the product but also provides a good buffering and protective effect.

[0019] (4) In the present invention, the formulation of the self-adhesive (medical acrylate) ensures excellent adhesion of the dressing, which can firmly adhere to the skin without using additional auxiliary adhesives and is easy to tear off without leaving residual glue; the addition of a reinforcing agent (polytetrafluoroethylene) effectively improves the mechanical strength and wear resistance of the dressing, enabling it to maintain stable physical properties during use.

[0020] (5) In the present invention, the components of the present formulation interact synergistically, not only ensuring the basic functions of the dressing (such as softness, liquid absorption, and air permeability), but also realizing multiple advantages of antibacterial, anti-corrosion, and mechanical enhancement; the preparation method adopts a chemical foaming and crosslinking process under mild conditions, with stable process, simple operation, convenient for large-scale industrial production, and having good market promotion prospects; this dressing not only meets the requirements of modern wound care for functionality, multi-level protection, and comfort, but also lays a foundation for the development of future personalized and intelligent medical materials. Detailed implementation manners

[0021] Example 1: A soft silicone foam dressing and its production method. First, prepare a functionalized silver-silane composite: Add 50 mL of ethanol and 10 mmol of 3-aminopropyltriethoxysilane into a reaction kettle, stir magnetically to disperse evenly. Dissolve 0.8 mmol of silver nitrate with 5 mL of ethanol, disperse evenly by ultrasound. Slowly add the obtained evenly dispersed silver nitrate solution to the 3-aminopropyltriethoxysilane solution while continuously stirring magnetically. After the addition is complete, continue stirring for 30 minutes. Under the state of magnetic stirring, dropwise add 0.6 mL of deionized water, then use dilute hydrochloric acid (0.1 mol / L) to adjust the pH of the solution to 4, raise the temperature to 40 °C, continue stirring for 1 h, and then cool naturally to room temperature. Filter the mixed solution through a vacuum filtration device, collect the precipitate or gel-like substance. Place the filtered product in a vacuum drying oven and dry at 30 °C for 6 h until the solvent is completely removed to obtain dry functionalized silver-silane composite powder. Then add 50% of the medical-grade soft silicone base liquid into a clean reaction kettle, heat the temperature to 60 °C, add 2% of a plasticizer (trimethylsilane), stir at 60 °C for 3 minutes. Under the state of continuous stirring, slowly add 2% of a crosslinking agent (vinyltrimethoxysilane), continue stirring for about 8 minutes, slowly add 1% of the functionalized silver-silane composite, continue stirring for about 8 minutes, slowly add 8% of a pre-uniformly dispersed liquid absorbent (superabsorbent resin) and 4% of a pre-uniformly dispersed air permeability enhancer (polytetrafluoroethylene), stir at low shear for 8 minutes. Subsequently, add 6% of a self-adhesive (medical acrylate) and 0.6% of a preservative (methylisothiazolinone), continue gentle stirring for 8 minutes. Then add 3% of a chemical foaming agent (carbon dioxide) for foaming, adjust the stirring speed to medium, and continue for 6 minutes, control the temperature at 70 °C. Quickly pour the foaming liquid into a pre-prepared mold, let it stand at room temperature for 10 minutes to make the preliminary foam structure stable and formed. Transfer the mold to an oven and cure at 80 °C for 2 h, then cool naturally to room temperature. After cutting and trimming, perform high-pressure steam sterilization treatment, and package in a sterile operation room to obtain the product.

[0022] Example 2: A soft polysiloxane foam dressing and its production method. First, a functionalized silver-silane composite is prepared: Add 50 mL of ethanol and 10 mmol of 3-aminopropyltriethoxysilane to a reaction kettle, stir magnetically until evenly dispersed, dissolve 0.9 mmol of silver nitrate in 5 mL of ethanol, disperse evenly by ultrasound, slowly drop the obtained evenly dispersed silver nitrate solution into the 3-aminopropyltriethoxysilane solution while continuously stirring magnetically, continue to stir for 30 minutes after dropping, while stirring magnetically, dropwise add 0.65 mL of deionized water, then adjust the pH of the solution to 4.25 using dilute hydrochloric acid (0.1 mol / L), raise the temperature to 45°C, continue to stir for 1.25 h and then cool naturally to room temperature. Filter the mixed solution through a vacuum filtration device, collect the precipitate or gel-like substance, place the filtered product in a vacuum drying oven, dry at 35°C for 7 h until the solvent is completely removed to obtain dry functionalized silver-silane composite powder. Then add 50% of the medical-grade soft polysiloxane base liquid to a clean reaction kettle, heat the temperature to 65°C, add 2.5% of a plasticizer (trimethylsilane), stir at 65°C for 4 minutes, while continuously stirring, slowly add 2.5% of a crosslinking agent (vinyltrimethoxysilane), continue to stir for about 9 minutes, slowly add 1.5% of the functionalized silver-silane composite, continue to stir for about 9 minutes, slowly add 9% of a pre-uniformly dispersed liquid absorbent (superabsorbent resin) and 5% of a pre-uniformly dispersed air permeability enhancer (polytetrafluoroethylene), stir at low shear for 9 minutes, then add 7% of a self-adhesive (medical acrylate) and 0.7% of a preservative (methylisothiazolinone), continue to gently stir for 9 minutes, then add 3.5% of a chemical foaming agent (carbon dioxide) for foaming, adjust the stirring speed to medium and continue for 7 minutes, control the temperature at 71°C, quickly pour the foaming liquid into a pre-prepared mold, let it stand at room temperature for 11 minutes to make the preliminary foam structure stable and formed, transfer the mold to an oven, cure at 85°C for 2.25 h, then cool naturally to room temperature, trim and finish, and then perform high-pressure steam sterilization treatment, and package in a sterile operation room to obtain the product.

[0023] Example 3: A soft silicone foam dressing and its production method. First, prepare a functionalized silver-silane composite: Add 50 mL of ethanol and 10 mmol of 3-aminopropyltriethoxysilane into a reaction kettle, stir magnetically to disperse evenly. Dissolve 1 mmol of silver nitrate in 5 mL of ethanol, disperse evenly by ultrasonic. Slowly drop the obtained evenly dispersed silver nitrate solution into the 3-aminopropyltriethoxysilane solution while continuously stirring magnetically. After dropping, continue stirring for 30 minutes. Under the state of magnetic stirring, dropwise add 0.7 mL of deionized water, then use dilute hydrochloric acid (0.1 mol / L) to adjust the pH of the solution to 4.5, heat up to 50 °C, continue stirring for 1.5 h and then cool naturally to room temperature. Filter the mixed solution through a vacuum filtration device, collect the precipitate or gel-like substance. Place the filtered product in a vacuum drying oven, dry at 40 °C for 8 h until the solvent is completely removed to obtain dry functionalized silver-silane composite powder. Then add 50% of medical-grade soft silicone base liquid into a clean reaction kettle, heat the temperature to 70 °C, add 3% of plasticizer (trimethylsilane), stir at 70 °C for 5 minutes. Under the state of continuous stirring, slowly add 3% of cross-linking agent (vinyltrimethoxysilane), continue stirring for about 10 minutes, slowly add 2% of functionalized silver-silane composite, continue stirring for about 10 minutes, slowly add 10% of pre-uniformly dispersed liquid absorbent (superabsorbent resin) and 6% of pre-uniformly dispersed air permeability enhancer (polytetrafluoroethylene), stir at low shear for 10 minutes. Then add 8% of self-adhesive (medical acrylate) and 0.8% of preservative (methylisothiazolinone), continue gentle stirring for 10 minutes. Then add 4% of chemical foaming agent (carbon dioxide) for foaming, adjust the stirring speed to medium, continue for 8 minutes, control the temperature at 72 °C. Quickly pour the foaming liquid into a pre-prepared mold, let it stand at room temperature for 12 minutes to make the preliminary foam structure stable and formed. Transfer the mold to an oven, cure at 90 °C for 2.5 h, then cool naturally to room temperature. After trimming, carry out high-pressure steam sterilization treatment and package in a sterile operation room to obtain the product.

[0024] Example 4: A soft silicone foam dressing and its production method. First, prepare a functionalized silver-silane composite: Add 50 mL of ethanol and 10 mmol of 3-aminopropyltriethoxysilane to a reaction kettle, stir magnetically to disperse evenly. Dissolve 1.1 mmol of silver nitrate in 5 mL of ethanol, disperse evenly by ultrasonic. Slowly add the obtained evenly dispersed silver nitrate solution to the 3-aminopropyltriethoxysilane solution while continuously stirring magnetically. After the addition, continue stirring for 30 minutes. Under the state of magnetic stirring, gradually add 0.75 mL of deionized water, then use dilute hydrochloric acid (0.1 mol / L) to adjust the pH of the solution to 4.75, heat up to 55°C, continue stirring for 1.75 h and then cool naturally to room temperature. Filter the mixed solution through a vacuum filtration device, collect the precipitate or gel-like substance. Place the filtered product in a vacuum drying oven and dry at 45°C for 9 h until the solvent is completely removed to obtain dry functionalized silver-silane composite powder. Then add 50% of medical-grade soft silicone base liquid to a clean reaction kettle, heat the temperature to 75°C, add 3.5% of a plasticizer (trimethylsilane), stir at 75°C for 6 minutes. Under continuous stirring, slowly add 3.5% of a cross-linking agent (vinyltrimethoxysilane), continue stirring for about 11 minutes, slowly add 2.5% of the functionalized silver-silane composite, continue stirring for about 11 minutes, slowly add 11% of a pre-uniformly dispersed liquid absorbent (superabsorbent resin) and 7% of a pre-uniformly dispersed air permeability enhancer (polytetrafluoroethylene), stir at low shear for 11 minutes. Subsequently, add 9% of a self-adhesive (medical acrylate) and 0.9% of a preservative (methylisothiazolinone), continue gentle stirring for 11 minutes, then add 4.5% of a chemical foaming agent (carbon dioxide) for foaming, adjust the stirring speed to medium, continue for 9 minutes, control the temperature at 73°C. Quickly pour the foaming liquid into a pre-prepared mold, let it stand at room temperature for 14 minutes to make the preliminary foam structure stable and formed. Transfer the mold to an oven, cure at 95°C for 2.75 h, then cool naturally to room temperature. After cutting and trimming, perform high-pressure steam sterilization treatment and package in a sterile operation room to obtain the product.

[0025] Example 5: A soft silicone foam dressing and its production method. First, prepare a functionalized silver-silane composite: Add 50 mL of ethanol and 10 mmol of 3-aminopropyltriethoxysilane into a reaction kettle, stir magnetically to disperse evenly. Dissolve 1.2 mmol of silver nitrate with 5 mL of ethanol, disperse evenly by ultrasonic. Slowly drop the obtained evenly dispersed silver nitrate solution into the 3-aminopropyltriethoxysilane solution while continuously stirring magnetically. After dropping, continue stirring for 30 minutes. Under the state of magnetic stirring, dropwise add 0.8 mL of deionized water, then use dilute hydrochloric acid (0.1 mol / L) to adjust the solution pH to 5, heat up to 60°C, continue stirring for 2 h and then cool naturally to room temperature. Filter the mixed solution through a vacuum filtration device, collect the precipitate or gel-like substance. Place the filtered product in a vacuum drying oven, dry at 50°C for 10 h until the solvent is completely removed to obtain dry functionalized silver-silane composite powder. Then add 50% of medical-grade soft silicone base liquid into a clean reaction kettle, heat the temperature to 80°C, add 4% of plasticizer (trimethylsilane), stir at 80°C for 7 minutes. Under the state of continuous stirring, slowly add 4% of crosslinking agent (vinyltrimethoxysilane), continue stirring for about 12 minutes, slowly add 3% of functionalized silver-silane composite, continue stirring for about 12 minutes, slowly add 12% of pre-uniformly dispersed liquid absorbent (superabsorbent resin) and 8% of pre-uniformly dispersed air permeability enhancer (polytetrafluoroethylene), stir at low shear for 12 minutes. Then add 10% of self-adhesive (medical acrylate) and 1% of preservative (methylisothiazolinone), continue gentle stirring for 12 minutes. Then add 5% of chemical foaming agent (carbon dioxide) for foaming, adjust the stirring speed to medium, continue for 10 minutes, control the temperature at 74°C. Quickly pour the foaming liquid into a pre-prepared mold, let it stand at room temperature for 15 minutes to make the preliminary foam structure stable and formed. Transfer the mold to an oven, cure at 100°C for 3 h, then cool naturally to room temperature. After cutting and trimming, perform high-pressure steam sterilization treatment, and package in a sterile operation room to obtain the product.

[0026] Performance testing Antibacterial performance testing The dressings obtained in Examples 1-5 were prepared into disc-shaped samples with a diameter of 10 mm and a thickness of about 1 mm. Then, they were ultrasonically cleaned (air-dried after ethanol washing) to remove surface impurities, sterilized using a V-PRO 2 type high-temperature and high-pressure sterilizer at a temperature of 121 °C for 15 minutes, and then cooled and reserved in a sterile environment. The Escherichia coli bacterial solution was evenly spread on the sterilized Mueller-Hinton agar medium to form a bacterial film. The sterilized dressing sample disc was evenly placed on the surface of the bacterial film. The petri dish was placed in a BD53 type constant temperature incubator at a set temperature of 37 °C and cultured for 24 hours. After the culture ended, a digital caliper was used to measure the diameter of the antibacterial zone formed around the sample and record it. Referring to the national standard GB / T 20944-2007, the following table shows the test results: Water absorption performance test The dressings obtained in Examples 1-5 were prepared into disc-shaped samples with a diameter of 30 mm and a thickness of about 1 mm. The samples were placed in a ventilated drying oven and dried at 40 °C for 24 hours until the sample mass was constant, and the dry weight (m1) was recorded. After the samples cooled to room temperature, the samples were completely immersed in distilled water (or simulated wound exudate) at 37 °C for 10 minutes to ensure that the samples were fully hydrated inside. After the immersion ended, the excess water on the surface of the samples was gently blotted with sterile filter paper (note not to squeeze the samples), and the mass of the wet samples was quickly weighed within 30 seconds and recorded as (m2). The water absorption rate (%) = ((m2 - m1) / m1) × 100%. Referring to the national standard 15710-2009, the following table shows the test results: Tensile strength and elongation at break test The dressings obtained in Examples 1-5 were prepared into strip-shaped samples of 50 mm × 10 mm. The samples were placed in a ventilated drying oven and dried at 40 °C for 24 hours until the sample mass was constant. The Instron 5942 type universal material testing machine was used to test their tensile strength and elongation at break. The pre-treated samples were fixed in the clamps of the Instron 5942 testing machine to ensure that the middle part of the samples was in the stress area, symmetrically clamped to avoid local stress concentration, and the set tensile rate was 50 mm / min. Referring to the national standard 528-2009, the following table shows the test results: Air permeability test Prepare the dressings obtained in Examples 1-5 into disc-shaped samples with a diameter of 30 mm and a thickness of about 1 mm. Place the samples in a ventilated drying oven and dry them at 40 °C for 24 hours until the sample mass is constant. Use a Messmer MTT-50 type air permeability tester to test the air permeability of the samples. Flatly install the pretreated samples on the sample stage of the air permeability tester, ensuring that the edges of the samples are sealed to avoid air leakage. Set the pressure difference at 100 Pa, the temperature at 23 °C, and the relative humidity at 65%. Record the volume of air passing through the samples per unit time. Referring to the national standard GB / T 5453-2010, the following table shows the test results:

Claims

1. A soft silicone foam dressing and a production method thereof, characterized in that: A soft silicone foam dressing and a production method thereof, comprising the steps of adding 50% of a medical-grade soft silicone base liquid into a clean reactor, heating the reactor to 60-80°C, adding 2-4% of a plasticizer, stirring the reactor at 60-80°C for 3-7 minutes, slowly adding 2-4% of a cross-linking agent under continuous stirring, continuing stirring for about 8-12 minutes, slowly adding 1-3% of a functionalized silver-silane complex, continuing stirring for about 8-12 minutes, slowly adding 8-12% of a pre-uniformly dispersed liquid absorbent and 4-8% of a pre-uniformly dispersed air permeability enhancer, stirring the mixture at low shear for 8-12 minutes, and then slowly adding the mixture. Then add 6-10% self-adhesive and 0.6-1% preservative, continue to stir gently for 8-12 minutes, and then add 3-5% chemical foaming agent for foaming, adjust the stirring speed to medium, continue for 6-10 minutes, control the temperature at 70-74°C, quickly pour the foaming liquid into the pre-prepared mold, let it stand at room temperature for 10-15 minutes to allow the preliminary foam structure to be stably formed, transfer the mold to an oven, cure at 80-100°C for 2-3h, then cool naturally to room temperature, cut and trim, use high-pressure steam sterilization, and package in a sterile operating room to obtain the product.

2. A soft silicone foam dressing and a production method thereof according to claim 1, characterized in that: The plasticizer is trimethylsilane.

3. A soft silicone foam dressing and a production method thereof according to claim 1, characterized in that: The crosslinking agent is vinyltrimethoxysilane.

4. A soft silicone foam dressing and a production method thereof according to claim 3, characterized in that: The preparation method of the functionalized silver-silane complex comprises the following steps: adding 50 mL of ethanol and 10 mmol of 3-aminopropyltriethoxysilane into a reaction kettle, uniformly dispersing by magnetic stirring, dissolving 0.8-1.2 mmol of silver nitrate in 5 mL of ethanol, uniformly dispersing by ultrasonication, slowly dropping the uniformly dispersed silver nitrate solution into the 3-aminopropyltriethoxysilane solution, while continuously magnetically stirring, and continuing to stir for 30 minutes after the dropwise addition is completed, and adding 0.6-0.8 mL of deionized water dropwise under magnetic stirring, and then adjusting the pH value of the solution to 4-5 with dilute hydrochloric acid (0.1 mol / L), heating to 40-60° C., continuing to stir for 1-2 hours, and then naturally cooling to room temperature, filtering the mixed solution through a vacuum filtration device, collecting precipitates or gel-like substances, placing the filtered product in a vacuum drying oven, and drying at 30-50° C. for 6-10 hours until the solvent is completely removed, thereby obtaining a dry functionalized silver-silane complex powder.

5. The soft silicone foam dressing and the production method thereof according to claim 1, characterized in that: The liquid absorbing agent is a super absorbent resin.

6. A soft silicone foam dressing and a production method thereof according to claim 1, characterized in that: The air permeability enhancer is polytetrafluoroethylene.

7. A soft silicone foam dressing and a production method thereof according to claim 1, characterized in that: The self-adhesive is medical acrylate.

8. The soft silicone foam dressing and the production method thereof according to claim 1, characterized in that: The preservative is methylisothiazolinone.

9. A soft silicone foam dressing and a production method thereof according to claim 1, characterized in that: The chemical blowing agent is carbon dioxide.

Images