Endometrial implanter

Abstract

The embodiment of the invention provides an endometrium implanting device which comprises an implanting part, a balloon, a first sleeve and a second sleeve, and the implanting part comprises a near end and a far end which are oppositely arranged in the first direction; the balloon is arranged at the far end; the balloon is sleeved with the second sleeve, the second sleeve is sleeved with the first sleeve, and the side, away from the balloon, of the second sleeve and the first sleeve are arranged in a spaced mode to form a storage space used for containing a biological membrane. In the process that the implanter extends into the uterus, under the protection of the first sleeve, after the balloon and the biological membrane of the implanter enter the uterine cavity through the outer vagina and the cervix uteri, the first sleeve and the second sleeve move towards the near end direction to release the balloon and the biological membrane, and then the balloon and the biological membrane are released. The balloon is converted from the folded state to the expanded state so that the biological membrane can be unfolded and attached to the damaged area of the inner wall of the uterine cavity in a supporting and pressing mode, the biological membrane is tightly attached to the damaged tissue in the early stage of biological membrane implantation, non-invasive transplantation is achieved, and therefore the transplantation success rate of the biological membrane is increased.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to an endometrial implant. Background Art

[0002] Endometrial defects usually refer to weak or damaged endometrium. Damage or loss of the endometrium may lead to infertility or miscarriage. Surgical transplantation of biofilms to repair the endometrium is an effective treatment method. However, the success rate of endometrial transplantation of biofilms to repair defects in related technologies is low. Summary of the invention

[0003] The embodiment of the present application provides an endometrial implant device, which aims to improve the success rate of endometrial transplantation biofilm repair defects.

[0004] An embodiment of the present application provides an endometrial implanter, comprising: an implantation portion, a balloon, a first sleeve and a second sleeve, the implantation portion extending along a first direction, the implantation portion comprising a proximal end and a distal end arranged opposite to each other along the first direction; the balloon is arranged at the distal end; the second sleeve is arranged at the distal end and sleeved on the outside of the balloon; the first sleeve is arranged at the distal end and sleeved on the outside of the second sleeve, the second sleeve is spaced apart from the first sleeve on a side away from the balloon to form a storage space, the storage space is used to accommodate a biofilm, the balloon has a folded state and an expanded state, the balloon is used to support the biofilm in the expanded state, the first sleeve and the second sleeve are movably arranged toward the proximal direction, the end of the first sleeve away from the proximal end is provided with a first opening, the first opening is used to pass the balloon and the biofilm, the end of the second sleeve away from the proximal end is provided with a second opening, the second opening is used to pass the balloon.

[0005] According to an embodiment of the present application, the implanter also includes a second sleeve, which is arranged at the distal end and sleeved on the outside of the balloon, the first sleeve is sleeved on the outside of the second sleeve, the first sleeve and the second sleeve are spaced apart to accommodate the biofilm, the second sleeve is movably arranged in the proximal direction, and a second opening is provided at the end of the second sleeve away from the proximal end, and the second opening is used to pass the balloon.

[0006] According to an embodiment of the present application, the implanter further comprises a biofilm, which is located between the first sleeve and the second sleeve, and the biofilm is wound around a side of the second sleeve facing away from the balloon.

[0007] According to an embodiment of the present application, a hanging hole is provided at one end of the biomembrane away from the proximal end, and the hanging hole is sleeved at the distal end and located at the side of the balloon away from the proximal end.

[0008] According to an embodiment of the present application, the balloon is converted from a folded state to an expanded state, and at least a portion of the side of the balloon away from the proximal direction moves in the direction away from the proximal end to press the biofilm to move in the direction away from the proximal end, so that the hanging hole and the distal end of the implant part are spaced apart along the first direction.

[0009] In an embodiment of the present application, the inserter further includes a cannula connection part, which includes a locking end and a connection end connected to each other. The connection end is disposed on the side of the locking end facing the distal end. The first cannula and the second cannula are connected to the connection end, and the locking end is sleeved on one side of the proximal end of the implant part. The locking end includes a locked state and a movable state; in the locked state, the locking end is locked to the implant part, and the first cannula and the second cannula are fixed at the distal end. In the movable state, the locking end is spaced apart from the implant part, and the cannula connection part is movably disposed along a first direction to drive the first cannula and the second cannula to be movably disposed along the first direction.

[0010] In an embodiment of the present application, a chute extending along the first direction is provided on the outer side wall of the implant part. The connection end is slidably connected to the chute. A first cannula buckle and a second cannula buckle are provided on the side of the connection end facing away from the chute. The first cannula is connected to the first cannula buckle, and the second cannula is connected to the second cannula buckle. The first cannula buckle is disposed on the side of the second cannula buckle facing the proximal end.

[0011] In an embodiment of the present application, a plurality of sealing flaps are connected to the end of the first cannula facing away from the proximal end. Adjacent two sealing flaps are adhesively bonded to each other by gelatin to seal the first opening.

[0012] In an embodiment of the present application, the implant part is provided with a first channel, a second channel, a first through hole and a second through hole. The first through hole communicates the balloon and the first channel to fill the medium into the balloon through the first channel. The second through hole communicates the second channel with the storage space.

[0013] In an embodiment of the present application, the inserter further includes a positioning probe, which is disposed at the end of the implant part facing away from the proximal end. The implant part is further provided with a wire channel, and a wire connecting the positioning probe is disposed in the wire channel.

[0014] In an embodiment of the present application, a tail seat is provided at the proximal end. The tail seat is provided with at least three interfaces. The first channel, the second channel and the wire channel extend along the first direction and are connected to the interfaces.

[0015] In an embodiment of the present application, in the expanded state, along the direction towards the proximal end, the diameter of the balloon gradually decreases.

[0016] In an embodiment of the present application, a balloon is disposed at the distal end. The balloon has a dilated state and a collapsed state. In the collapsed state, the balloon contracts at the distal end of the implantation portion to reduce the volume of the balloon. A second cannula is disposed at the distal end and sleeved outside the balloon, thereby maintaining the balloon in the collapsed state and reducing the size of the implantator in a direction perpendicular to the first direction. A first cannula is disposed at the distal end and sleeved outside the second cannula. A storage space is formed between the side of the second cannula facing away from the balloon and the first cannula for accommodating the biofilm. The second cannula separates the biofilm and the balloon, reducing direct contact between the biofilm and the balloon. The biofilm is sleeved outside the second cannula. During the process of the distal end of the implantator extending into the uterus, protected by the first cannula, it is convenient for the balloon of the implantator and the biofilm to enter the uterine cavity through the hysteroscopic treatment channel or directly through the external vagina and cervix, reducing the contact between the biofilm and the implantation channel or the body, reducing the contamination of the biofilm, and achieving the purpose of aseptic protection. At the same time, the biofilm is implanted into the endometrial defect site of the uterine cavity, reducing mechanical irritation and damage to the cervix and uterine cavity of the entry channel. One end of the first cannula facing away from the proximal end is provided with a first opening, and one end of the second cannula facing away from the proximal end is provided with a second opening. After the first cannula, the second cannula, the biofilm, and the balloon extend into the uterus, the first cannula and the second cannula are moved in the direction towards the proximal end. The first opening is for passing the balloon and the biofilm, and the second opening is for passing the balloon, leaving the balloon and the biofilm in the uterine cavity. The balloon is converted from the collapsed state to the dilated state in the uterine cavity. The volume of the balloon in the dilated state is larger than that in the collapsed state. The balloon is converted from the collapsed state to the dilated state to push and unfold the biofilm, and the balloon in the dilated state is used to support the biofilm, attaching the biofilm to the damaged area of the uterine inner wall, realizing non-invasive transplantation of the biofilm to the damaged site of the uterine inner wall. In the initial stage of implanting the biofilm, the biofilm adheres tightly to the damaged tissue, thereby improving the success rate of non-invasive transplantation of the biofilm. At the same time, placing the balloon in the dilated state in the uterine cavity for a certain period of time during treatment can improve the problem of intrauterine adhesion. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Other features, objects, and advantages of the present application will become more apparent by reading the following detailed description of non-limiting embodiments with reference to the accompanying drawings, in which like or similar reference numerals represent like or similar features.

[0018] Figure 1 is a schematic structural diagram of an endometrial implantator provided by an embodiment of the present application;

[0019] Figure 2 is a schematic structural diagram of another endometrial implantator provided by an embodiment of the present application;

[0020] Figure 3 is a schematic structural diagram of an implantation portion provided by an embodiment of the present application;

[0021] Figure 4 It is a schematic structural diagram of an implantation part and a balloon in a retracted state provided by an embodiment of the present application;

[0022] Figure 5 It is a schematic structural diagram of an implantation part and a balloon in a dilated state provided by an embodiment of the present application;

[0023] Figure 6 It is a schematic structural diagram of a first cannula provided by an embodiment of the present application;

[0024] Figure 7 It is a schematic structural diagram of a second cannula provided by an embodiment of the present application;

[0025] Figure 8 It is a schematic partial structural diagram of an endometrial implantor provided by an embodiment of the present application;

[0026] Figure 9a It is a schematic partial structural diagram of another endometrial implantor provided by an embodiment of the present application;

[0027] Figure 9b It is Figure 9a The cross-sectional view at point A in

[0028] Figure 9c It is Figure 9a The cross-sectional view at point B in

[0029] Figure 10 It is a schematic diagram of a biofilm in an unfolded state provided by an embodiment of the present application;

[0030] Figure 11 It is Figure 10 The winding state diagram of the biofilm in

[0031] Figure 12 It is Figure 10 The winding state diagram of the biofilm in

[0032] Figure 13 It is a schematic diagram of another biofilm in an unfolded state provided by an embodiment of the present application;

[0033] Figure 14 It is Figure 13 The winding state diagram of the biofilm in

[0034] Figure 15 It is a schematic partial structural diagram of another endometrial implantor provided by an embodiment of the present application;

[0035] Figure 16 It is a schematic partial structural diagram of another endometrial implantor provided by an embodiment of the present application;

[0036] Figure 17 It is Figure 16 The cross-sectional view at point A in

[0037] Figure 18 It is a schematic structural diagram of a casing connection part provided by an embodiment of the present application;

[0038] Figure 19 It is a partial structural schematic diagram of another endometrial implant provided by an embodiment of the present application;

[0039] Figure 20 It is a schematic structural diagram of a locking part provided by an embodiment of the present application;

[0040] Figure 21 It is a schematic structural diagram of a locking handle provided by an embodiment of the present application;

[0041] Figure 22 It is a schematic structural diagram of a tailstock provided by an embodiment of the present application;

[0042] Figure 23 It is another partial structural schematic diagram of the tailstock provided by an embodiment of the present application;

[0043] Figure 24 It is yet another partial structural schematic diagram of the tailstock provided by an embodiment of the present application;

[0044] Figure 25 It is a schematic structural diagram of a check valve provided by an embodiment of the present application;

[0045] Figure 26 It is another schematic structural diagram of a check valve provided by an embodiment of the present application;

[0046] Figure 27 It is a schematic structural diagram of the proximal end of an implant part provided by an embodiment of the present application.

[0047] Explanation of reference numerals: 10, biofilm; 11, hanging hole; 100, implant part; 110, proximal end; 120, distal end; 130, chute; 140, first channel; 141, first through hole; 150, second channel; 151, second through hole; 160, positioning probe; 170, wire channel; 200, balloon; 300, first casing; 310, first opening; 320, sealing flap; 330, first buttonhole; 400, second casing; 410, second opening; 420, second buttonhole; 500, casing connection part; 510, locking end; 511, connection part; 512, locking part; 513, locking handle; 514, locking piece; 515, inner wall; 520, connection end; 521, first casing buckle; 522, second casing buckle; 600, tailstock; 610, interface; 611, first interface; 612, second interface; 613, wire interface; 614, first slider; 620, check valve; 621, inlet part; 622, duckbill part; X, first direction. Detailed Implementation Modes

[0048] The features and exemplary embodiments of various aspects of the present application will be described in detail below. In the following detailed description, many specific details are set forth in order to provide a thorough understanding of the present application. However, it will be apparent to those skilled in the art that the present application may be practiced without some of these specific details. The following description of the embodiments is only intended to provide a better understanding of the present application by showing examples of the present application. In the drawings and the following description, at least some of the well-known structures and technologies are not shown in order to avoid unnecessarily obscuring the present application; and, for clarity, the dimensions of some structures may be exaggerated. In addition, the features, structures, or characteristics described below may be combined in any suitable manner in one or more embodiments.

[0049] In the description of the present application, it should be noted that unless otherwise specified, the meaning of "a plurality of" is two or more; the orientation or positional relationships indicated by the terms "upper", "lower", "left", "right", "inner", "outer", etc. are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as a limitation of the present application. In addition, the terms "first", "second", etc. are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0050] The orientation terms appearing in the following description are all the directions shown in the drawings and do not limit the specific structure of the embodiments of the present application. In the description of the present application, it should also be noted that unless otherwise clearly specified and limited, the terms "mounted", "connected" should be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be directly connected or indirectly connected. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0051] As Figures 1 to 9cAs shown, an endometrial implant provided by an embodiment of the present application includes: an implantation portion 100, a balloon 200, and a first sleeve 300. The implantation portion 100 extends along a first direction X. The implantation portion 100 includes a proximal end 110 and a distal end 120 that are oppositely arranged along the first direction X; the balloon 200 is arranged at the distal end 120; a second sleeve 400 is arranged at the distal end 120 and sleeved outside the balloon 200. The first sleeve 300 is arranged at the distal end 120 and sleeved outside the second sleeve 400. A storage space is formed by a gap between the side of the second sleeve 400 facing away from the balloon 200 and the first sleeve 300. The storage space is used to accommodate a biofilm 10. The balloon 200 has a collapsed state and an expanded state. The balloon 200 is used to support the biofilm 10 in the expanded state. The first sleeve 300 and the second sleeve 400 are movably arranged in the direction towards the proximal end 110. A first opening 310 is provided at one end of the first sleeve 300 facing away from the proximal end 110, and a second opening 410 is provided at one end of the second sleeve 400 facing away from the proximal end 110. The first opening 310 is used to pass through the balloon 200 and the biofilm 10, and the second opening 410 is used to pass through the balloon 200.

[0052] In this embodiment, the balloon 200 is arranged at the distal end 120. The balloon 200 has an expanded state and a collapsed state, as Figure 1 and Figure 4As shown, when the balloon 200 is in the collapsed state, the balloon 200 shrinks at the distal end 120 of the implantation portion 100 to reduce the volume of the balloon 200. The second sleeve 400 is disposed at the distal end 120 and sleeved outside the balloon 200, thereby holding the balloon 200 in the collapsed state and reducing the dimension of the implantator along the direction perpendicular to the first direction X. The first sleeve 300 is disposed at the distal end 120 and sleeved outside the second sleeve 400. A storage space is formed by spacing between the side of the second sleeve 400 facing away from the balloon 200 and the first sleeve 300 for accommodating the biofilm 10. The second sleeve 400 spaces apart the biofilm 10 and the balloon 200, reducing the direct contact between the biofilm 10 and the balloon 200. The biofilm 10 is sleeved outside the second sleeve 400. During the process of the distal end 120 of the implantator extending into the uterus, protected by the first sleeve 300, it is convenient for the balloon 200 of the implantator and the biofilm 10 to enter the uterine cavity through the hysteroscopic treatment channel or directly through the outer vagina and cervix, reducing the contact between the biofilm and the implantation channel or the body, and reducing the contamination of the biofilm, achieving the purpose of aseptic protection. Through the treatment channel of the operative hysteroscope or the vagina and cervix, the biofilm 10 is implanted into the endometrial defect site of the uterine cavity. One end of the first sleeve 300 facing away from the proximal end 110 is provided with a first opening 310, and one end of the second sleeve 400 facing away from the proximal end 110 is provided with a second opening 410. After the first sleeve 300, the second sleeve 400, the biofilm 10 and the balloon 200 extend into the uterine cavity, the first sleeve 300 and the second sleeve 400 are moved along the direction towards the proximal end 110. The first opening 310 is for passing the balloon 200 and the biofilm 10, and the second opening 410 is for passing the balloon 200, leaving the balloon 200 and the biofilm 10 exposed in the uterine cavity. As Figure 5 As shown, the balloon 200 is converted from the collapsed state to the expanded state in the uterus. The volume of the balloon 200 in the expanded state is larger than that in the collapsed state. The balloon 200 is converted from the collapsed state to the expanded state to push and unfold the biofilm 10. The balloon 200 in the expanded state is used to support the biofilm 10, attaching the biofilm 10 to the damaged area of the uterine inner wall, realizing non-invasive transplantation. In the initial stage of implanting the biofilm 10, the biofilm 10 is closely attached to the damaged tissue, thereby improving the success rate of non-invasive transplantation of the biofilm. And placing the balloon in the expanded state in the uterine cavity for a certain time during the treatment can improve the problem of intrauterine adhesion.

[0053] The implantation portion 100 extends along the first direction X, and the dimension of the implantation portion 100 along the direction perpendicular to the first direction X is small, so that the implantator can implant the biofilm 10 into the endometrial injury site through the hysteroscopic treatment channel under hysteroscopic assistance.

[0054] Optionally, the diameter of the first cannula 300 is 4 mm to 6.5 mm, so that the side of the applicator near the distal end 120 can enter the uterus through the treatment channel of the hysteroscope. The diameter of the first cannula 300 can be 4 mm, 4.5 mm, 5 mm, 5.5 mm, 6 mm, 6.5 mm, etc.

[0055] Optionally, the diameter of the first cannula 300 is 4 mm to 10 mm, so that the side of the applicator near the distal end 120 can directly enter the uterine cavity through the cervix. The diameter of the first cannula 300 can be 4 mm, 4.5 mm, 5 mm, 5.5 mm, 6 mm, 6.5 mm, 7 mm, 8 mm, 9 mm, 10 mm, etc.

[0056] As Figure 9b shown, in some alternative embodiments, the applicator further includes a biofilm 10, the biofilm 10 is located between the first cannula 300 and the second cannula 400, and the biofilm 10 is wound around the side of the second cannula 400 facing away from the balloon 200.

[0057] In these alternative embodiments, the biofilm 10 is wound around the side of the second cannula 400 facing away from the balloon 200. After the second cannula 400 moves in the direction towards the proximal end 110, the biofilm 10 is located on the circumferential side of the balloon 200, so that the balloon 200 can push and unfold the biofilm 10. The biofilm 10 contracts within the first cannula 300. The first cannula 300 can fix the biofilm 10 on the side of the second cannula 400 facing away from the balloon 200, and the first cannula 300 can keep the biofilm 10 in a contracted state, which is beneficial to reducing the volume of the applicator, and thus passing through the treatment channel of the operative hysteroscope; or directly implanting the biofilm 10 into the endometrial defect site of the uterine cavity through the vagina and cervix, avoiding friction between the biofilm 10 and the human implantation tract.

[0058] As Figures 9a to 14 shown, in some alternative embodiments, a hanging hole 11 is provided at one end of the biofilm 10 facing away from the proximal end 110, and the hanging hole 11 is sleeved on the distal end 120 and located on the side of the balloon 200 facing away from the proximal end 110.

[0059] In these alternative embodiments, a hanging hole 11 is provided at one end of the biofilm 10 facing away from the proximal end 110. The hanging hole 11 is sleeved on the distal end 120 of the implantation portion 100 to fix the relative position between the biofilm 10 and the implantation portion 100, improving the accuracy of the implantation position of the biofilm 10. The hanging hole 11 is sleeved on the distal end 120 and is located on the side of the balloon 200 facing away from the proximal end 110. When the balloon 200 is converted from the collapsed state to the expanded state, the balloon 200 can push the biofilm 10 in the direction away from the proximal end 110, and at this time, the distal end 120 of the implantation portion 100 disengages from the hanging hole 11. The hanging hole 11 of the biofilm 10 does not affect the repair effect of the biofilm 10 implanted in the endometrium. The hanging hole 11 will soon be filled with newly formed endometrial tissue, and the hanging hole 11 is conducive to the climbing of newly formed endometrial cells and tissues on the biofilm 10, facilitating the combination of the biofilm 10 with the endometrium.

[0060] Optionally, as Figure 1 , Figure 3 and Figures 10 to 14 shown, when the balloon 200 is converted from the collapsed state to the expanded state, at least a part of the side of the balloon 200 facing away from the proximal end 110 moves in the direction away from the proximal end 110 to press the biofilm 10 to move in the direction away from the proximal end 110, so that the hanging hole 11 and the distal end 120 of the implantation portion 100 are spaced apart along the first direction X, causing the hanging hole 11 to disengage from the implantation portion 100, thereby enabling the biofilm 10 to be unfolded.

[0061] Optionally, as Figures 10 to 14 shown, the number of the hanging holes 11 can be one or more. When the number of the hanging holes 11 is multiple, the multiple hanging holes 11 are sequentially sleeved on the proximal end 110 of the implantation portion 100, so that the biofilm 10 is sequentially and orderly wound around and mounted on the distal end 120 of the implantation portion. When the balloon 200 expands, the biofilm 10 can be smoothly pushed out, and then the expanded balloon 200 will cause the biofilm 10 to open according to the winding and stacking order, facilitating the smooth unfolding of the implanted biofilm 10 and flattening it against the inner wall of the uterine cavity.

[0062] Optionally, as Figure 13 and Figure 14 shown, the biofilm 10 is circular, the hanging hole 11 is provided at the center of the biofilm 10, and the circular biofilm 10 surrounds the second sleeve 400. When the balloon 200 is in the expanded state, it can support the biofilm 10 at the end of the implantor facing away from the proximal end 110, and the biofilm 10 adheres to the side of the endometrium close to the uterine fundus. Among them, Figure 13 is the unfolded state of the biofilm 10, Figure 14 is the wound state of the biofilm 10.

[0063] Optionally, as Figures 10 to 12As shown, the biofilm 10 is rectangular, and a plurality of hanging holes 11 are arranged side by side on one side of the biofilm 10. The rectangular biofilm 10 surrounds the second sleeve 400, and the plurality of hanging holes 11 are located at one end of the implantation part 100 away from the proximal end 110 and are sequentially sleeved on the distal end 120 of the implantation part 100. When the balloon 200 is in the expanded state, the biofilm 10 is pushed out in the direction away from the proximal end 110, and the distal end 120 of the implantation part 100 sequentially disengages from the plurality of hanging holes 11. The biofilm 10 unfolds and is located on one side of the balloon 200 perpendicular to the first direction X and fits with the endometrium. Figure 10 is the unfolded state of the biofilm 10, Figure 11 and Figure 12 is the wound state of the biofilm 10.

[0064] Different shapes of the biofilm 10 and different distributions of the hanging holes 11 are located in different positions in the uterus after unfolding, so as to be able to fit different parts of the uterus, so that the biofilm 10 can be accurately implanted into the damaged part of the uterus.

[0065] Such as Figure 1 、 Figure 2 and Figures 15 to 19 As shown, in some alternative embodiments, the inserter further includes a sleeve connection part 500. The sleeve connection part 500 includes a locking end 510 and a connection end 520 that are connected to each other. The connection end 520 is arranged on the side of the locking end 510 facing the distal end 120. The first sleeve 300 and the second sleeve 400 are connected to the connection end 520. The locking end 510 is sleeved on one side of the proximal end 110 of the implantation part 100. The locking end 510 includes a locked state and a movable state; in the locked state, the locking end 510 is locked to the implantation part 100, and the first sleeve 300 and the second sleeve 400 are fixed to the distal end 120. In the movable state, the locking end 510 is spaced from the implantation part 100, and the sleeve connection part 500 is movably arranged along the first direction X to drive the first sleeve 300 and the second sleeve 400 to be movably arranged along the first direction X.

[0066] In these alternative embodiments, the cannula connection portion 500 includes a locking end 510 and a connection end 520 that are connected to each other. The connection end 520 is disposed on a side of the locking end 510 facing the distal end 120 to facilitate the connection of the first cannula 300 and the second cannula 400. The locking end 510 includes a locked state and a movable state. In the locked state, the locking end 510 is locked to the implant portion 100, and the first cannula 300 and the second cannula 400 are connected to the locking end 510 through the connection end 520, so that the first cannula 300 and the second cannula 400 are fixed to the distal end 120, fixing the positions of the first cannula 300 and the second cannula 400 during the use of the implantor. In the movable state, the locking end 510 is spaced apart from the implant portion 100, and the cannula connection portion 500 is movably disposed along the first direction X, that is, the locking end 510 and the connection end 520 are movably disposed along the first direction X, so as to drive the first cannula 300 and the second cannula 400 to be movably disposed along the first direction X, driving the first cannula 300 and the second cannula 400 to move toward the proximal end 110 to expose the balloon 200 and the biofilm 10.

[0067] Optionally, as Figures 15 to 21 shown, the locking end 510 includes a connection portion 511, a locking portion 512, and a locking handle 513 that are sequentially disposed along a direction away from the distal end 120. The connection portion 511 is connected between the connection end 520 and the locking portion 512. The locking portion 512 includes a plurality of locking pieces 514 disposed around the implant portion 100. The locking pieces 514 are located on a side of the locking portion 512 facing the locking handle 513. The locking handle 513 is provided with an inner side wall 515 surrounding the peripheral side of the locking pieces 514. Along the direction away from the distal end 120, the diameter of the opening formed by enclosing the inner side wall 515 gradually decreases. The locking handle 513 is threadedly connected to the locking portion 512. When the locking handle 513 is rotated to move the locking handle 513 in a direction close to the distal end 120, the inner side wall 515 abuts against the locking pieces 514 so that the locking pieces 514 abut against the implant portion 100, so that the locking portion 512 is locked to the implant portion 100, and the locking end 510 is in the locked state. When the locking handle 513 is rotated to move the locking handle 513 in a direction away from the distal end 120, the locking pieces 514 move in a direction away from the implant portion 100 so that the locking pieces 514 are spaced apart from the implant portion 100, so that the locking end 510 is in the movable state.

[0068] As Figure 5 、 Figure 8 and Figure 16As shown, in some alternative embodiments, a chute 130 extending in the first direction X is provided on the outer sidewall of the implanting portion 100. The connecting end 520 is slidably connected to the chute 130. On the side of the connecting end 520 facing away from the chute 130, a first sleeve buckle 521 and a second sleeve buckle 522 are provided. The first sleeve 300 is connected to the first sleeve buckle 521, and the second sleeve 400 is connected to the second sleeve buckle 522. The first sleeve buckle 521 is provided on the side of the second sleeve buckle 522 facing the proximal end 110.

[0069] In these alternative embodiments, the connecting end 520 is slidably connected to the chute 130, so that the connecting end 520 can move along the first direction X, improving the problem of the connecting end 520 rotating relative to the implanting portion 100, thereby reducing the probability of relative rotation of the first sleeve 300 and the second sleeve 400 relative to the implanting portion 100, reducing the influence of the first sleeve 300 and the second sleeve 400 on the position and winding state of the biofilm 10, and enhancing the position accuracy of the biofilm 10 attached to the inner wall of the uterus. On the side of the connecting end 520 facing away from the chute 130, a first sleeve buckle 521 and a second sleeve buckle 522 are provided. The first sleeve buckle 521 is provided on the side of the second sleeve buckle 522 facing the proximal end 110. The first sleeve 300 is located outside the second sleeve 400. The connection of the second sleeve 400 to the second sleeve buckle 522 enables the second sleeve 400 not to block the first sleeve buckle 521, so that the first sleeve 300 can be connected to the first sleeve buckle 521. The first sleeve 300 includes a first buckle eye 330 sleeved on the first sleeve buckle 521, and the second sleeve 400 includes a second buckle eye 420 sleeved on the second sleeve buckle 522.

[0070] As Figure 6 shown, in some alternative embodiments, a plurality of sealing flaps 320 are connected to the end of the first sleeve 300 facing away from the proximal end 110. Adjacent two sealing flaps 320 are adhesively bonded to each other by gelatin to seal the first opening 310.

[0071] In these alternative embodiments, the plurality of sealing flaps 320 are sequentially connected to the first sleeve 300 to seal the first opening 310, thereby reducing the risk of biofilm 10 contamination. Adjacent two sealing flaps 320 are adhesively bonded to each other by gelatin. The gelatin dissolves after contacting human body fluid, and the adhesion between the sealing flaps 320 fails to open the first opening 310 for the balloon 200 and the biofilm 10. Gelatin is easily absorbed by the human body, thereby reducing the damage to the human body.

[0072] Optionally, as Figure 6 shown, the plurality of sealing flaps 320 are sequentially connected to form a tip on the side facing away from the proximal end 110, thereby facilitating the inserter to pass through the cervix and into the uterine cavity.

[0073] As Figure 9a 、 Figure 9b and Figure 9cAs shown, in some alternative embodiments, the implanting portion 100 is provided with a first channel 140, a second channel 150, a first through hole 141, and a second through hole 151. The first through hole 141 communicates with the balloon 200 and the first channel 140 to fill the balloon 200 with a medium through the first channel 140. The second through hole 151 communicates with the second channel 150 and the storage space.

[0074] In these alternative embodiments, the medium enters the balloon 200 through the first channel 140 and the first through hole 141 to convert the balloon 200 from a collapsed state to an expanded state. The medium is retained within the balloon 200 so that the balloon 200 presses the biofilm 10 against the defect site on the inner wall of the uterus for a certain period of time, improving the implantation efficiency and success rate of the biofilm 10. After the operation, the medium within the balloon 200 is released through the first channel 140 and the first through hole 141, causing the volume of the balloon 200 to decrease so that the balloon 200 can exit the cervical orifice and detach from the uterus. The medium can be a liquid or a gas. When the medium is a liquid, it can reduce the internal pressure of the balloon 200 and improve the safety and reliability of the implanting portion 100. The second through hole 151 communicates with the storage space between the first sleeve 300 and the second channel 150. By injecting a stem cell culture solution or a growth factor solvent, etc. into the second channel 150, the stem cell culture solution or the growth factor solvent, etc. enters the first sleeve 300 through the second through hole 151, and the stem cell culture solution or the growth factor solvent, etc. seeps into the storage space between the first sleeve 300 and the second sleeve 400 and thus penetrates the biofilm 10. The first sleeve 300 and the second sleeve 400 form a relatively independent space for accommodating the stem cell culture solution or the growth factor solvent, enabling the stem cell culture solution or the growth factor solvent to fully infiltrate the biofilm 10. The stem cell culture solution can promote endometrial regeneration. Factors such as vascular endothelial growth factor in the stem cell culture solution can promote the formation of new blood vessels, providing the necessary blood supply for endometrial regeneration. The anti-inflammatory factors in the stem cell culture solution can regulate the local immune environment, reduce the inflammatory response, and are beneficial to tissue repair. The growth factors in the stem cell culture solution can promote the proliferation and differentiation of endometrial cells and accelerate endometrial regeneration. Alternatively, mesenchymal stem cells or endometrial stem cells are filled into the uterine cavity implanting membrane through the second channel 150 and the second through hole 151 to promote endometrial regeneration. The second channel 150 and the second through hole 151 can also be injected with a bioadhesive for tissue adhesion, hemostasis, and wound repair of the biofilm 10, etc.

[0075] Optionally, a guide wire is further provided within the second channel 150. The guide wire disposed within the second channel 150 can enhance the rigidity of the implanting portion 100 to facilitate the inserter to extend into the uterus through the cervical orifice. The material of the guide wire can include titanium alloy.

[0076] Optionally, as Figure 6As shown, two adjacent sealing flaps 320 are adhesively bonded to each other by gelatin, and stem cell culture medium or growth factor solvent can dissolve the gelatin to open the first opening 310.

[0077] As Figure 1 shown, in some alternative embodiments, the implantor further includes a positioning probe 160 disposed at one end of the implanting portion 100 away from the proximal end 110. The implanting portion 100 is further provided with a wire channel 170, and a wire connecting the positioning probe 160 is disposed in the wire channel 170.

[0078] In these alternative embodiments, the positioning probe 160 is used to position the implanting position, improving the accuracy of the implanting position of the biofilm 10. Optionally, under the assistance of a hysteroscope, the damaged position is visually located and magnetic powder is injected to establish a magnetic field positioning and tracing target point. The positioning probe 160 is disposed at the distal end 120 and can be a magnetic control probe. Under the magnetic field navigation, the biofilm 10 is accurately attached to the damaged part, improving the success rate of implantation. The implanting portion 100 is further provided with a wire channel 170, and a wire connecting the positioning probe 160 is disposed in the wire channel 170, so that the positioning probe 160 is electrically connected to the power supply of the magnetic control navigation system and the signal processing device through the wire.

[0079] As Figure 22 and Figure 23 shown, in some alternative embodiments, the proximal end 110 is provided with a tailstock 600. The tailstock 600 is provided with at least three interfaces 610, and the first channel 140, the second channel 150, and the wire channel 170 extend along the first direction X and are connected to the interfaces 610.

[0080] In these alternative embodiments, the tailstock 600 is connected to the proximal end 110 of the implanting portion 100. The tailstock 600 is provided with at least three interfaces 610, and the three interfaces 610 are respectively connected to the first channel 140, the second channel 150, and the wire channel 170. The first channel 140, the second channel 150, and the wire channel 170 extend along the first direction X and are connected to the interfaces 610. The interfaces 610 include a first interface 611, a second interface 612, and a wire interface 613. The first interface 611 communicates with the first channel 140, and the medium enters the first channel 140 through the first interface 611. The second interface 612 communicates with the second channel 150, and the wire interface 613 is connected to the wire channel 170.

[0081] Optionally, as Figures 24 to 26 shown, a check valve 620 is disposed in at least one of the first interface 611 and the second interface 612. The check valve 620 can allow the fluid to enter the first channel 140 or the second channel 150 through the interface 610, reducing the backflow of the fluid from the first channel 140 and the second channel 150 to the first interface 611 and the second interface 612.

[0082] Optionally, as Figure 25 and Figure 26 shown, the check valve 620 has an inlet portion 621 and a duckbill portion 622. The diameter of the duckbill portion 622 gradually decreases in the direction away from the inlet portion 621, and the material of the duckbill portion 622 is elastic. The duckbill portion 622 can pass the liquid flowing from the inlet portion 621 to the duckbill portion 622, and the duckbill portion 622 can prevent the liquid in the first channel 140 or the second channel 150 from flowing through the duckbill portion 622 to the inlet portion 621.

[0083] Optionally, as Figure 27 shown, the first channel 140, the second channel 150, and the wire channel 170 extend along the first direction X and penetrate through the proximal end 110 of the implantation portion 100 to communicate with the interface 610.

[0084] Optionally, as Figure 23 shown, the tailstock 600 is provided with a first slider 614. The first slider 614 is disposed on the side of the slide rail away from the distal end 120, so that the tailstock 600 is fixed to the implantation portion 100, reducing the risk of the tailstock 600 rotating relative to the implantation portion 100, so as to ensure that the first interface 611 communicates with the first channel 140, the second interface 612 communicates with the second channel 150, and the wire interface 613 is connected to the wire channel 170.

[0085] As Figure 5 shown, in some alternative embodiments, in the expanded state, the diameter of the balloon 200 gradually decreases in the direction towards the proximal end 110.

[0086] In these alternative embodiments, when the balloon 200 is located in the uterine cavity, one end of the balloon 200 away from the proximal end 110 is close to the uterine fundus, and one end of the balloon 200 towards the proximal end 110 is close to the cervix. In the expanded state, the diameter of the balloon 200 gradually decreases in the direction towards the proximal end 110, so that the balloon 200 adapts to the shape inside the uterus.

[0087] Optionally, in the expanded state, the diameter of the side of the balloon 200 away from the proximal end 110 is 20 mm to 35 mm, specifically, it can be 20 mm, 22 mm, 25 mm, 30 mm, 33 mm, 35 mm, etc. The diameter of the side of the balloon 200 towards the proximal end 110 is 10 mm to 15 mm, specifically, it can be 10 mm, 12 mm, 14 mm, 15 mm, etc.

[0088] Optionally, in the expanded state, the length of the balloon 200 along the first direction X is 60 mm to 80 mm, specifically, it can be 60 mm, 65 mm, 70 mm, 75 mm, 80 mm, etc.

[0089] Optionally, the material of the implantation part 100 includes polypropylene. Polypropylene has high strength, good chemical corrosion resistance, and certain elasticity.

[0090] Although the present application has been described with reference to the preferred embodiments, various modifications can be made to it and components therein can be replaced with equivalents without departing from the scope of the present application. In particular, as long as there is no structural conflict, the technical features mentioned in each embodiment can be combined in any way. The present application is not limited to the specific embodiments disclosed in the text, but includes all technical solutions falling within the scope of the claims.

Claims

1. An endometrial implant, characterized in that: include: An implant portion extending along a first direction, the implant portion comprising a proximal end and a distal end oppositely disposed along the first direction; a balloon, disposed at the distal end; A second sleeve, disposed at the distal end and sleeved on the outside of the balloon; The first sleeve is arranged at the distal end and sleeved on the outside of the second sleeve. The second sleeve is spaced apart from the first sleeve on a side away from the balloon to form a storage space. The storage space is used to accommodate the biofilm. The balloon has a folded state and an expanded state. The balloon is used to support the biofilm in the expanded state. The first sleeve and the second sleeve are movably arranged toward the proximal direction. The first sleeve is provided with a first opening at one end away from the proximal end. The first opening is used to pass the balloon and the biofilm. The second sleeve is provided with a second opening at one end away from the proximal end. The second opening is used to pass the balloon.

2. The implanter according to claim 1, characterized in that The implanter further comprises the biofilm, which is located between the first sleeve and the second sleeve, and is wound around a side of the second sleeve away from the balloon.

3. The implanter according to claim 2, characterized in that A hanging hole is arranged at one end of the biofilm away from the proximal end, and the hanging hole is sleeved on the distal end and located at a side of the balloon away from the proximal end.

4. The implanter according to claim 3, characterized in that The balloon is converted from the folded state to the expanded state, and at least a part of the balloon moves away from the proximal direction on one side thereof to press the biofilm to move away from the proximal direction, so that the hanging hole and the distal end of the implant part are spaced apart along the first direction.

5. The implanter according to claim 1, characterized in that The implanter further comprises a sleeve connecting portion, the sleeve connecting portion comprises a locking end and a connecting end connected to each other, the connecting end is arranged at a side of the locking end facing the distal end, the first sleeve and the second sleeve are connected to the connecting end, the locking end is sleeved at a side of the proximal end of the implant part, and the locking end comprises a locking state and an active state; In the locked state, the locking end is locked to the implant part, and the first sleeve and the second sleeve are fixed to the distal end. In the active state, the locking end is spaced apart from the implant part, and the sleeve connecting part is movably arranged along the first direction to drive the first sleeve and the second sleeve to be movably arranged along the first direction.

6. The implanter according to claim 5, characterized in that The outer wall of the implant part is provided with a slide groove extending along the first direction, the connecting end is slidably connected to the slide groove, and the side of the connecting end away from the slide groove is provided with a first sleeve buckle and a second sleeve buckle, the first sleeve is connected to the first sleeve buckle, the second sleeve is connected to the second sleeve buckle, and the first sleeve buckle is provided on the side of the second sleeve buckle facing the proximal end.

7. The implanter according to claim 1, characterized in that A plurality of sealing flaps are connected to the end of the first sleeve away from the proximal end, and two adjacent sealing flaps are bonded to each other by gelatin to seal the first opening.

8. The implanter according to claim 1, characterized in that The implant part is provided with a first channel, a second channel, a first through hole and a second through hole. The first through hole connects the balloon and the first channel so as to fill the medium into the balloon through the first channel. The second through hole connects the second channel and the storage space.

9. The implanter according to claim 8, characterized in that The implanter further comprises a positioning probe, which is arranged at an end of the implant part away from the proximal end. The implant part is also provided with a wire channel, in which a wire connected to the positioning probe is arranged.

10. The implanter according to claim 9, characterized in that The proximal end is provided with a tailstock, and the tailstock is provided with at least three interfaces. The first channel, the second channel, and the wire channel extend along the first direction and connect the interfaces.

11. The implanter according to claim 1, characterized in that: In the expanded state, the diameter of the balloon gradually decreases along the proximal direction.

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