A traditional Chinese medicine composition for treating renal clear cell carcinoma, a preparation method and application thereof

Abstract

The application discloses a traditional Chinese medicine composition for treating renal clear cell carcinoma and a preparation method and application thereof, and belongs to the technical field of medicines. The traditional Chinese medicine composition provided by the application comprises ginseng, astragalus, atractylodes, poria cocos, herba impatiens, oldenlandia, zedoary, dogwood fruit, ligustrum lucidum and prunella vulgaris. The traditional Chinese medicine composition provided by the application is scientific and reasonable in combination, can support healthy qi and eliminate pathogenic factors, clear heat and resolve toxins, activate blood and resolve stasis, and soften and resolve hard masses. The clinical experimental results show that the traditional Chinese medicine composition provided by the application can effectively treat renal clear cell carcinoma, and the treatment efficiency is better than that of the targeted drug sorafenib; and the medicine is safe, has no obvious toxic and side effects, and performs well in improving patient's traditional Chinese medicine syndromes, improving the quality of life and reducing the level of tumor markers. The application provides a new idea and method for treating renal clear cell carcinoma, and has significant clinical significance and important popularization value.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of medicine, in particular to a traditional Chinese medicine composition for treating renal clear cell carcinoma and a preparation method and application thereof. BACKGROUND

[0002] Renal clear cell carcinoma is the most common pathological type of renal carcinoma, accounting for 70-80% of renal carcinoma. Renal clear cell carcinoma has high invasiveness and metastasis, and early symptoms are not obvious. Most patients are in the advanced stage when diagnosed, and the prognosis is poor. At present, surgical resection is the main treatment for renal clear cell carcinoma, but for patients with advanced or metastatic renal clear cell carcinoma, the surgical effect is limited and often accompanied by serious complications. In recent years, targeted therapy and immunotherapy have made some progress in the treatment of renal clear cell carcinoma, but these treatment methods have problems such as high cost and large side effects, which limit their widespread application.

[0003] Traditional Chinese medicine has a long history and rich experience in the treatment of tumors. Its holistic concept and treatment principle of syndrome differentiation provide a new way of thinking and method for the treatment of renal clear cell carcinoma. Traditional Chinese medicine can improve the quality of life and survival rate of patients by strengthening the body resistance, regulating the body's immune function, and reducing symptoms. Therefore, it is of great clinical significance to develop an effective traditional Chinese medicine composition for treating renal clear cell carcinoma. SUMMARY

[0004] The purpose of the present application is to provide a traditional Chinese medicine composition for treating renal clear cell carcinoma and a preparation method and application thereof, to solve the problems existing in the prior art. The traditional Chinese medicine composition provided by the present application is reasonably matched and can effectively treat renal clear cell carcinoma, and is safe and has no obvious toxic and side effects.

[0005] To achieve the above-mentioned purpose, the present application provides the following solutions:

[0006] The present application provides a traditional Chinese medicine composition for treating renal clear cell carcinoma, which comprises the following raw material components by weight:

[0007] Radix ginseng 10-15 parts, Radix astragali 15-20 parts, Rhizoma atractylodis 10-15 parts, Poria cocos 10-15 parts, Hedyotis diffusa 15-20 parts, Oldenlandia diffusa 15-20 parts, Curcuma zedoaria 10-15 parts, Fructus corni 10-15 parts, Ligustri lucidi Fructus 10-15 parts and Prunella vulgaris 10-15 parts.

[0008] Preferably, the following raw material components are included by weight:

[0009] Radix ginseng 12 parts, Radix astragali 18 parts, Rhizoma atractylodis 12 parts, Poria cocos 12 parts, Hedyotis diffusa 18 parts, Oldenlandia diffusa 18 parts, Curcuma zedoaria 12 parts, Fructus corni 12 parts, Ligustri lucidi Fructus 12 parts and Prunella vulgaris 12 parts.

[0010] Ginseng: sweet, slightly bitter, warm. Spleen, lung, heart, kidney. Has a large tonic, pulse, solid, tonic spleen and lungs, blood, calm the mind and wisdom. In the party as the monarch, for the tonic, enhance the body's resistance, positive.

[0011] Radix Astragali: sweet, slightly warm. Spleen, lung. Has a tonic, Wei, solid, water, swelling, poison, muscle efficiency. In the party as the minister, help ginseng tonic, enhance the body's immune function, while water, swelling, reduce the symptoms of edema caused by tumors.

[0012] Atractylodes: bitter, sweet, warm. Spleen, stomach. Has a spleen, gas, dry, water efficiency. In the party as the minister, spleen, enhance the function of the stomach, promote the source of blood, for the positive and evil.

[0013] Poria: sweet, mild, flat. Heart, spleen, kidney. Has a water, wet, spleen, heart. In the party as the minister, water, wet, reduce the symptoms of water and wet caused by tumors, while spleen, heart, improve the patient's mental state.

[0014] Herba Dendrodii: bitter, pungent, cold. Lungs, liver, kidney. Has a heat, detoxification, blood, water efficiency. In the party as a drug, heat, detoxification, blood, water, directly to the pathological characteristics of the tumor, inhibit tumor growth.

[0015] Herba Hedyotis Diffusae: bitter, sweet, cold. Lungs, liver, large intestine. Has a heat, detoxification, wet, anti-cancer effect. In the party as a drug, with half a branch of the role of synergy, enhance the heat, detoxification, anti-cancer effect.

[0016] Rhizoma Zedoariae: bitter, pungent, warm. Liver, spleen. Has a gas, blood, accumulation, pain. In the party as a drug, gas, blood, accumulation, improve the symptoms of gas and blood caused by tumors, promote the dispersion of tumors.

[0017] Cornus: sour, astringent, slightly warm. Liver, kidney. Has a tonic, liver and kidney, astringent efficiency. In the party as a drug, tonic, liver and kidney, enhance the body's positive, while astringent, prevent the leakage of essence.

[0018] Fructus Ligustri Lucidi: sweet, bitter, cool. Liver, kidney. Has a tonic, liver and kidney, clear liver, eyes. In the party as a drug, tonic, liver and kidney, enhance the body's positive.

[0019] Folium Lycii: bitter, pungent, cold. Liver, gallbladder. Has a clear liver, scattered, the efficiency. In the party as a drug, clear liver, scattered, improve the symptoms of liver fire caused by tumors, while the drug into the liver, enhance the overall efficacy of the prescription.

[0020] The application further provides a preparation method of the traditional Chinese medicine composition, comprising the following steps:

[0021] The raw material components of the traditional Chinese medicine composition are weighed, mixed, soaked with water, heated to boiling, kept to micro-boiling decoction, filtered, and the filtrate and the residue are collected respectively;

[0022] The residue is added with water, heated to boiling, kept to micro-boiling decoction, filtered, and the secondary filtrate is collected, and the filtrate and the secondary filtrate are combined, so that the traditional Chinese medicine composition is obtained.

[0023] Preferably, the soaking time is 30-60 min.

[0024] Preferably, the time for keeping to micro-boiling decoction is 20-30 min.

[0025] The application further provides an application of the traditional Chinese medicine composition in preparation of a medicine for treating renal clear cell carcinoma.

[0026] The application further provides a medicine for treating renal clear cell carcinoma, wherein the medicine takes the traditional Chinese medicine composition as a main raw material.

[0027] Preferably, the medicine further comprises a pharmaceutically acceptable excipient.

[0028] Preferably, the dosage form of the medicine is any one of a decoction, a pill, a plaster, a granule and a tablet.

[0029] Preferably, the dosage form of the medicine is a decoction.

[0030] The application discloses the following technical effects:

[0031] I. Strengthening body resistance and treating both symptoms and root causes

[0032] The traditional Chinese medicine composition of the application takes ginseng and astragalus as monarch and minister drugs to enhance the disease resistance of the body; meanwhile, takes Kadsura japonica and Sarcandra glabra as auxiliary drugs with the effects of clearing heat and resolving toxins and anticancer to directly treat the pathological characteristics of tumors. This scheme of treating both symptoms and root causes can not only improve the clinical symptoms of patients, but also effectively inhibit the growth and metastasis of tumors.

[0033] II. High safety and no obvious toxic side effects

[0034] Compared with targeted therapy and immunotherapy, the traditional Chinese medicine composition of the application has no obvious toxic side effects in the treatment process, and the patient has good tolerance. This shows that the traditional Chinese medicine composition can improve the survival rate of patients while significantly improving the quality of life of patients, and has high clinical application value.

[0035] III. Multi-target action mechanism

[0036] The traditional Chinese medicine composition of this invention, through the synergistic action of multiple active ingredients, exerts multiple benefits, including immunomodulation, anti-inflammatory, antioxidant, tumor cell proliferation inhibition, and apoptosis induction. For example, saponins in ginseng can enhance immune function, while flavonoids in Scutellaria barbata and Hedyotis diffusa have significant anti-cancer activity. This multi-target mechanism of action gives it a unique advantage in the treatment of clear cell renal cell carcinoma.

[0037] 4. Significant clinical efficacy

[0038] In clinical validation, the total effective rate in the treatment group reached 75.00%, significantly higher than the 58.33% in the control group (P < 0.05). Furthermore, the treatment group demonstrated significant advantages in improving TCM symptoms, enhancing quality of life, and reducing tumor marker levels. These results demonstrate that the Chinese medicine composition of the present invention has high clinical value in the treatment of clear cell renal cell carcinoma. DETAILED DESCRIPTION

[0039] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0040] It should be understood that the terms described herein are intended only to describe particular embodiments and are not intended to limit the present invention. In addition, for numerical ranges herein, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. The intermediate value within any stated value or stated range, and each smaller range between any other stated value or intermediate value within the stated range, is also encompassed within the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded within the scope.

[0041] Unless otherwise indicated, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art. Although only preferred methods and materials are described herein, any methods and materials similar or equivalent to those described herein may also be used in the practice or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of any conflict with any incorporated document, the contents of this specification shall prevail.

[0042] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments described herein without departing from the scope or spirit of the invention. Other embodiments will be apparent to those skilled in the art from the description of the invention. The description and examples are intended to be illustrative only.

[0043] As used herein, "comprise", "comprising", "having", "including", "contain", "containing", "include" and the like are open-ended terms that are intended to mean including but not limited to.

[0044] The compatibility of the traditional Chinese medicine composition prescription of the present application follows the treatment principle of "strengthening the body resistance and eliminating pathogenic factors" in traditional Chinese medicine. In the prescription, ginseng, astragalus, atractylodes, and poria are the monarch and ministerial drugs, which tonify the body resistance and enhance the body's resistance to disease. Half branch orchid, white flower snake grass, zedoary, dogwood, ligustrum fruit, and summer grass are the auxiliary drugs, which clear heat and resolve toxins, remove blood stasis and resolve mass, and directly treat the pathological characteristics of tumors. Strengthening the body resistance without leaving pathogenic factors, eliminating pathogenic factors without damaging the body resistance, achieving the purpose of strengthening the body resistance and eliminating pathogenic factors, and resisting cancer and eliminating tumors. The prescription not only focuses on tonifying the body resistance and enhancing the body's resistance to disease (treating the root cause), but also focuses on clearing heat and resolving toxins, removing blood stasis, and improving the clinical symptoms of patients (treating the symptoms). Through the treatment of both the root and the branch, the overall treatment effect is achieved.

[0045] Ginseng as the monarch drug of the prescription contains various active ingredients such as ginsenosides (Rg3, Rh2, etc.), which can significantly enhance the immune function of the body, improve the activity of T cells, B cells, and natural killer cells (NK cells), and enhance the body's immune surveillance and clearance ability of tumor cells. Rg3 can inhibit tumor cell angiogenesis and reduce tumor nutrition supply, thereby inhibiting tumor growth. Astragalus polysaccharide in astragalus can enhance the activity of macrophages and T cells, promote the secretion of cytokines (such as IL-2, TNF-α), and thereby enhance the body's immune response. Atractylodes and poria have the effects of regulating immunity, anti-inflammation, and antioxidant, which can improve the internal environment of the body, reduce the inflammatory response caused by tumors, and enhance the overall resistance of the body. Half branch orchid and white flower snake grass contain various anticancer active ingredients such as flavonoids and polysaccharides, which can inhibit the proliferation of tumor cells, induce tumor cell apoptosis, and have antioxidant and anti-inflammatory effects, thereby reducing the oxidative stress damage caused by tumors. Zedoary alcohol in zedoary has a significant anti-tumor effect, which can inhibit the growth and metastasis of tumor cells, induce tumor cell apoptosis, and has anti-inflammatory and immune regulation effects. Summer grass as the auxiliary drug of the prescription contains summer grass polysaccharide and flavonoids, which can inhibit the proliferation of tumor cells, induce tumor cell apoptosis, and have anti-inflammatory and antioxidant effects, thereby reducing the inflammatory response caused by tumors.

[0046] Example 1

[0047] A traditional Chinese medicine composition for treating renal clear cell carcinoma, comprising the following raw materials: ginseng 12g, astragalus 18g, atractylodes 12g, poria 12g, half branch orchid 18g, white flower snake grass 18g, zedoary 12g, dogwood 12g, ligustrum fruit 12g, and summer grass 12g.

[0048] Preparation method: the above raw medicine is mixed together, put into the medicine jar, add 552ml water to immerse, soak for 45min, after heating to boiling, keep micro-boiling decoction for 25min, filter, get filtrate A and filter residue; add 276ml water to immerse in filter residue, after heating to boiling, keep micro-boiling decoction for 25min, filter, get filtrate B, combine filtrate A and filtrate B, mix evenly, which is the traditional Chinese medicine composition for treating renal clear cell carcinoma.

[0049] Example 2

[0050] A traditional Chinese medicine composition for treating renal clear cell carcinoma, comprising the following raw materials: 10g of ginseng, 15g of astragalus, 10g of white atractylodes, 10g of poria, 15g of hemipilose, 15g of belamcanda, 10g of curcuma, 10g of dogwood fruit, 10g of ligustrum fruit, and 10g of prunella.

[0051] Preparation method: the above raw medicine is mixed together, put into the medicine jar, add 460ml water to immerse, soak for 30min, after heating to boiling, keep micro-boiling decoction for 20min, filter, get filtrate A and filter residue; add 230ml water to immerse in filter residue, after heating to boiling, keep micro-boiling decoction for 20min, filter, get filtrate B, combine filtrate A and filtrate B, mix evenly, which is the traditional Chinese medicine composition for treating renal clear cell carcinoma.

[0052] Example 3

[0053] A traditional Chinese medicine composition for treating renal clear cell carcinoma, comprising the following raw materials: 15g of ginseng, 20g of astragalus, 15g of white atractylodes, 15g of poria, 20g of hemipilose, 20g of belamcanda, 15g of curcuma, 15g of dogwood fruit, 15g of ligustrum fruit, and 15g of prunella.

[0054] Preparation method: the above raw medicine is mixed together, put into the medicine jar, add 660ml water to immerse, soak for 60min, after heating to boiling, keep micro-boiling decoction for 30min, filter, get filtrate A and filter residue; add 330ml water to immerse in filter residue, after heating to boiling, keep micro-boiling decoction for 30min, filter, get filtrate B, combine filtrate A and filtrate B, mix evenly, which is the traditional Chinese medicine composition for treating renal clear cell carcinoma.

[0055] Comparative example 1

[0056] A traditional Chinese medicine composition for treating renal clear cell carcinoma, which is different from example 1 only in that ginseng is replaced by radix codonopsis and astragalus is replaced by ganoderma in the raw materials.

[0057] Comparative example 2

[0058] A traditional Chinese medicine composition for treating renal clear cell carcinoma, which is different from example 1 only in that hemipilose is replaced by rhizoma davidine in the raw materials.

[0059] Comparative Example 3

[0060] A traditional Chinese medicine composition for treating renal clear cell carcinoma, which differs from Example 1 only in that the raw materials of the traditional Chinese medicine composition are: Herba Hedyotis Diffusae 20 g, Herba Belamcanda 20 g, Rhizoma Atractylodis Macrocephalae 12 g, Poria Cocos 12 g, Curcuma Aromatica 12 g, Fructus Corni 12 g, Ligustri Lucidi Fructus 12 g, and Prunella Vulgaris 12 g.

[0061] Effect verification example 1

[0062] 1. Case data

[0063] 120 cases of renal clear cell carcinoma patients were selected, all of which were patients diagnosed as renal clear cell carcinoma by pathological examination after kidney cancer surgery in a certain third-grade class-A hospital. They were randomly divided into a treatment group and a control group, with 60 cases in each group. The treatment group was given the traditional Chinese medicine composition prepared in Example 1 of the application, and the control group was given western medicine treatment. There was no significant difference in age, gender, and disease condition between the two groups, and they were comparable.

[0064] 2. Diagnostic criteria

[0065] 2.1 Western medicine diagnostic criteria:

[0066] According to the TNM staging standard for renal cancer formulated by the International Anti-Cancer Alliance (UICC), combined with the results of imaging examination (such as CT, MRI, etc.) and pathological examination, it was diagnosed as renal clear cell carcinoma.

[0067] 2.2 TCM syndrome diagnostic criteria:

[0068] According to the syndrome differentiation type of renal cancer in “Traditional Chinese Medicine Oncology”, it was diagnosed as kidney deficiency and blood stasis.

[0069] Main symptoms: lumbago, lumbago, lassitude, sallow complexion, purple tongue or ecchymosis, and pulse.

[0070] Secondary symptoms: dizziness, tinnitus, insomnia, and dreaminess.

[0071] 3. Treatment plan

[0072] Treatment group: Take the traditional Chinese medicine composition prepared in Example 1 of the application, 1 dose per day, taken in the morning and evening, and continuously taken for 3 months as a course of treatment.

[0073] Control group: According to the specific condition of the patient, give the targeted therapy drug sorafenib, and the treatment cycle is 3 months.

[0074] 4. Efficacy evaluation criteria

[0075] 4.1 Short-term efficacy: According to the Response Evaluation Criteria in Solid Tumors (RECIST 1.1 version), it is divided into complete remission (CR), partial remission (PR), stable (SD), and progression (PD).

[0076] Efficiency = (CR + PR) / total number of cases x 100%.

[0077] 4.2 TCM syndrome efficacy: according to the Guiding Principles for Clinical Research on New Drugs of Traditional Chinese Medicine, the TCM syndrome efficacy index = (pre-treatment score - post-treatment score) / pre-treatment score x 100% is calculated by the nimodipine method.

[0078] Cure: TCM syndrome efficacy index ≥ 95%;

[0079] Marked effectiveness: TCM syndrome efficacy index ≥ 70%;

[0080] Effectiveness: TCM syndrome efficacy index ≥ 30%;

[0081] Ineffectiveness: TCM syndrome efficacy index < 30%.

[0082] 5. Treatment results

[0083] According to the above treatment regimen, 120 patients with renal clear cell carcinoma were treated by oral administration of the traditional Chinese medicine composition prepared in Example 1 of the present application and the western medicine targeted drug sorafenib in the treatment group and the control group, respectively. The efficacy was counted after 1 course of treatment. The specific results are as follows:

[0084] Table 1: Recent efficacy statistics of each group

[0085] Group Cases Complete remission Partial remission Stable Progression Effective rate / % Treatment group 60 5 40 10 5 75.00 Control group 60 3 32 15 10 58.33

[0086] Table 1 shows that the total effective rate of the treatment group is 75.00%, which is significantly higher than that of the control group (58.33%) (P < 0.05), indicating that the traditional Chinese medicine composition of the present application has a significant advantage in inhibiting tumor growth.

[0087] Table 2: TCM syndrome efficacy statistics of each group

[0088]

[0089]

[0090] Table 3: Changes in TCM syndrome scores before and after treatment

[0091] Group Pre-treatment score (mean ± SD) Post-treatment score (mean ± SD) Difference (mean ± SD) P value Treatment group 20.5±3.2 5.8±2.1 14.7±1.8 <0.05 Control group 20.3±3.1 10.2±2.5 10.1±1.6 <0.05

[0092] As can be seen from Tables 2 and 3, the TCM syndrome effective rate of the treatment group is 83.33%, which is significantly higher than that of the control group (66.67%) (P < 0.05), indicating that the traditional Chinese medicine composition of the present application has a significant effect on improving the TCM syndrome of patients.

[0093] Table 4: Changes in quality of life scores before and after treatment

[0094] Group Pre-treatment score (mean ± SD) Post-treatment score (mean ± SD) Difference (mean ± SD) P value Treatment group 65.2±7.8 85.6±2.1 20.4±3.2 <0.05 Control group 64.8±8.1 75.3±7.2 10.5±2.8 <0.05

[0095] According to the results in Table 4, the quality of life score of the treatment group after treatment is significantly higher than that of the control group (P<0.05), indicating that the traditional Chinese medicine composition of the application can significantly improve the quality of life of patients.

[0096] Table 5 Changes in tumor markers (CEA, CA19-9) before and after treatment

[0097]

[0098] The results in Table 5 show that the levels of tumor markers change: the levels of CEA and CA19-9 in the treatment group after treatment significantly decrease, and are better than those in the control group (P<0.05), indicating that the traditional Chinese medicine composition of the application has a significant effect on inhibiting tumor activity.

[0099] Example 2 for verifying effect

[0100] Select 60 patients with renal clear cell carcinoma, give the traditional Chinese medicine composition prepared in Comparative Example 1 for treatment, and the treatment regimen and efficacy determination criteria are the same as those in the treatment group in Example 1 for verifying effect.

[0101] Table 6 Recent efficacy

[0102] Cases Complete remission Partial remission Stable Progression Effective rate / % 60 2 28 18 12 50.00

[0103] Table 7 TCM syndrome efficacy

[0104] Cases Recovery Marked effectiveness Effectiveness Ineffectiveness TCM syndrome effective rate / % 60 4 12 22 22 63.33

[0105] Table 8 TCM syndrome score

[0106]

[0107]

[0108] Table 9 Quality of life score

[0109] Pre-treatment score (mean ± SD) Post-treatment score (mean ± SD) Difference (mean ± SD) P value 65.1±8.2 77.2±7.5 12.1±3.7 <0.05

[0110] Table 10 Changes in tumor marker levels

[0111]

[0112] In Example 2 for verifying effect, the traditional Chinese medicine composition of Comparative Example 1 is significantly lower than the traditional Chinese medicine composition of Example 1 of the application in terms of recent efficacy in treating renal clear cell carcinoma, TCM syndrome efficacy, improvement in quality of life, and reduction in tumor marker levels, indicating that its efficacy is relatively weak, further confirming the scientificity of the compatibility of each medicinal material in the traditional Chinese medicine composition of the application and the importance of the synergistic effect.

[0113] In conclusion, the traditional Chinese medicine composition has significant clinical effect in treating renal clear cell carcinoma, the compatibility follows the treatment principle of TCM'strengthening healthy energy and eliminating pathogenic factors', and the combination of tonifying healthy energy and clearing heat and resolving stasis achieves treating both symptoms and root causes. According to the clinical verification result, the total effective rate of the treatment group is significantly higher than that of the control group, and the treatment group has obvious advantages in improving TCM syndromes, improving the quality of life and reducing the level of tumor markers.

[0114] The above-described embodiments are only used to describe the preferred modes of the present application, and are not used to limit the scope of the present application, and various modifications and improvements to the technical solutions of the present application made by those skilled in the art without departing from the design spirit of the present application shall fall within the protection scope of the present application defined by the claims.

Claims

1. Use of a traditional Chinese medicine composition in the preparation of a medicament for treating renal clear cell carcinoma, characterized in that: The Chinese medicine composition is composed of the following raw materials in parts by weight: 12 parts of ginseng, 18 parts of astragalus, 12 parts of atractylodes, 12 parts of tuckahoe, 18 parts of scutellaria barbata, 18 parts of oldenlandia diffusa, 12 parts of zedoaria, 12 parts of cornus officinalis, 12 parts of glossy privet fruit and 12 parts of selfheal.

2. A Chinese medicine composition for treating renal clear cell carcinoma, characterized in that: By weight, it is composed of the following raw materials: 12 parts of ginseng, 18 parts of astragalus, 12 parts of atractylodes, 12 parts of tuckahoe, 18 parts of scutellaria barbata, 18 parts of oldenlandia diffusa, 12 parts of zedoaria, 12 parts of cornus officinalis, 12 parts of glossy privet fruit and 12 parts of selfheal.

3. A method for preparing the Chinese medicine composition according to claim 2, characterized in that: The following steps are involved: Weighing the raw material components of the traditional Chinese medicine composition, mixing them evenly, soaking them in water, heating them to boiling, decocting them while maintaining a slight boiling, filtering them, and collecting the filtrate and filter residue respectively; Add water to the filter residue, heat to boiling, maintain a slight boiling point, filter, collect a secondary filtrate, and combine the filtrate and the secondary filtrate to obtain the traditional Chinese medicine composition.

4. The preparation method according to claim 3, wherein The soaking time is 30-60 minutes.

5. The preparation method according to claim 3, wherein The time for maintaining the slight boiling is 20-30 minutes.

6. A drug for treating renal clear cell carcinoma, characterized in that: The medicine uses the traditional Chinese medicine composition according to claim 2 as the main raw material.

7. The drug according to claim 6, characterized in that Pharmaceutically acceptable excipients are also included.

8. The drug according to claim 7, wherein The dosage form of the medicine is any one of decoction, pill, paste, granule and tablet.

9. The drug according to claim 8, wherein The dosage form of the medicine is decoction.

Images