Synergistic pesticide composition and method of making same

Abstract

The invention provides a synergistic pesticide composition and a manufacturing method thereof, and particularly provides a synergistic pesticide composition which can improve crop pesticide resistance management and effectively control plant pathogenic fungi and harmful arthropods under the condition that the dosage is low and an active compound with a lower concentration is included. And meanwhile, the compound has enhanced activity and wider active spectrum on harmful pests. The synergistic pesticide composition comprises A) a pyrazole pesticide, B) a thiourea pesticide and C) a pesticide selected from the group of pesticides or fungicides.

Description

Technical Field

[0001] The present invention relates to a synergistic pesticide composition comprising A) a pyrazole insecticide, B) a thiourea insecticide, and C) a pesticide selected from the group consisting of insecticides or fungicides. Background Art

[0002] Traditionally, preventive methods for pest control have been crop rotation between different crops and planting pest - and disease - free rootstocks. These methods are neither cost - effective nor efficient.

[0003] Determining suitable pesticide combinations and their respective dosages is a complex process that faces many challenges, including antagonism between pesticides, dosage determination, and the development of resistance.

[0004] There is a current need for effective pesticide compositions to overcome one or more deficiencies related to the development of resistance, limited target pests, arthropods with specific feeding mechanisms, high dosage ranges, pesticide application frequency, soil and planting site degradation, crop damage, and crop yield.

[0005] The compositions of the present invention effectively control and protect plants from harmful arthropods and fungal diseases that attack various crops and plants, and contribute to increasing the yield of treated plants. The compositions of the present invention can also improve the quality of plants related to the size, color, appearance, and / or shape of plant parts and plant products. When the compositions or formulations of the present invention are used to control harmful arthropods and fungal diseases, they can also extend the storage life, maintain product quality, increase post - harvest life, and protect against post - harvest losses.

[0006] CN103609576A relates to a compound pesticide composition and its preparation method, and discloses a binary composition of tolfenpyrad and diafenthiuron.

[0007] CN103271051A discloses a tolfenpyrad - diafenthiuron binary compound insecticide composition.

[0008] WO2011144593A1 discloses a binary composition consisting of pyraclostrobin and another insecticide.

[0009] The present disclosure aims to solve the above problems and provides a ternary synergistic pesticide composition comprising A) a pyrazole insecticide, B) a thiourea insecticide, and C) a pesticide selected from the group consisting of insecticides or fungicides.

[0010] Object of the Invention

[0011] For effective resistance management and effective control of phytopathogenic fungi and harmful arthropods at the lowest possible application rates, one aspect of the present invention is to provide a composition which, while reducing the total amount of active compounds applied, has enhanced activity and a broader activity spectrum against harmful pests and is particularly suitable for specific conditions. Summary of the Invention

[0012] The present invention provides a synergistic pesticide composition which is capable of improving crop resistance management and effectively controlling phytopathogenic fungi and harmful arthropods while using low doses and including lower concentrations of active compounds, and at the same time has enhanced activity and a broader activity spectrum against harmful pests.

[0013] It has been found that this object is achieved by a synergistic pesticide composition which comprises A) a pyrazole insecticide, B) a thiourea insecticide and C) a pesticide selected from the group consisting of insecticides or fungicides. Detailed Description of the Invention

[0014] In describing the embodiments of the present invention, specific terms are used for the sake of clarity. However, the present invention is not intended to be limited to the specific terms selected, and it should be understood that each specific term includes all technical equivalents of similar methods of operation for achieving similar purposes.

[0015] As used herein, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. As used herein, the terms "comprising", "including", "having", "containing", "involving", etc. are understood to mean including but not limited to. The terms "preferred" and "preferably" refer to embodiments of the present invention which may provide certain advantages in certain circumstances. As used herein, the term "about" should be construed to mean "approximately" or "reasonably close" and any statistically insignificant variations therefrom. As used herein, the term "at least" indicates that a number or quantity is the smallest or minimum possible, and larger numbers or quantities are also possible.

[0016] The recitation of numerical ranges herein is merely intended to serve as a shorthand method of referring individually to each separate numerical value falling within the range. Unless otherwise indicated herein, each separate value is incorporated into the specification as if it were individually recited herein.

[0017] Unless otherwise indicated herein or clearly contradicted by context, all methods described herein can be performed in any suitable order. The use of any and all examples or exemplary language (e.g., "such as") provided herein for certain embodiments of the present invention is merely intended to better illuminate the present invention and does not constitute a limitation on the scope of the present invention otherwise claimed.

[0018] The term "control" means the elimination of the pathogen under study. 100% control means the complete elimination of the pathogen. The terms "composition" and "formulation" are used interchangeably and have a similar meaning. The terms "plant" and "crop" are used interchangeably.

[0019] In a preferred embodiment, the present invention relates to a synergistic pesticidal composition comprising A) a pyrazole insecticide, B) a thiourea insecticide, and C) at least one pesticide selected from the group consisting of insecticides or fungicides.

[0020] In a preferred embodiment, the present invention relates to a synergistic pesticidal composition comprising A) tolfenpyrad, B) diafenthiuron, and C) at least one pesticide selected from the group consisting of insecticides or fungicides.

[0021] In one embodiment, the present invention provides a synergistic pesticidal composition comprising A) a pyrazole insecticide, B) a thiourea insecticide, and C) at least one additional insecticide or fungicide selected from the group consisting of:

[0022] C (1) Synthetic pyrethroids selected from the group consisting of bifenthrin, lambda-cyhalothrin, cypermethrin, deltamethrin, etofenprox, fenpropathrin;

[0023] C (2) Neonicotinoid insecticides selected from the group consisting of acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam;

[0024] C (3) Chordotonal organ modulator insecticides selected from the group consisting of flonicamid or pymetrozine;

[0025] C (4) Compounds of unknown or non-specific mode of action (mite growth inhibitors) selected from the group consisting of clofentezine, hexythiazox, etoxazole;

[0026] C(5) Mitochondrial complex I electron transport inhibitors METI acaricides, selected from the group including fenazaquin, fenpyroximate, pyrimidifen, pyridaben;

[0027] C (6) Lipid synthesis inhibitor tetronic acid derivatives, selected from the group including spirodiclofen, spiromesifen;

[0028] C (7) Ryanodine receptor modulators, selected from the group including diamides, flubendiamide;

[0029] C (8) Antibiotic fungicides, selected from the group including kasugamycin, polyoxins;

[0030] C (9) Strobilurin fungicides, selected from the group including azoxystrobin, kresoxim-methyl, picoxystrobin, pyraclostrobin, trifloxystrobin;

[0031] C (10) Aromatic fungicides, including chlorothalonil;

[0032] C (11) Carbamate fungicides, including thiophanate-methyl;

[0033] C (12)Triazole fungicides, selected from the group consisting of cyproconazole, difenoconazole, epoxiconazole, flusilazole, hexaconazole, ipconazole, myclobutanil, penconazole, propiconazole, prothioconazole, tebuconazole, tetraconazole, triadimefon;

[0034] C (13) Copper fungicides, selected from the group consisting of copper hydroxide, copper oxychloride, copper sulfate;

[0035] C (14) GABA-gated chloride channel allosteric modulator insecticides, selected from the group consisting of fluxametamide, isocycloseram;

[0036] C (15) Sulfoxamine insecticides, including sulfoxaflor;

[0037] C (16) Chitin synthesis inhibitor insecticides, selected from the group consisting of bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron;

[0038] C (17) Inorganic fungicides, including sulfur;

[0039] C (18) Dithio-carbamate fungicides, including propineb;

[0040] C (19)Anilino - pyrimidine fungicides, selected from the group consisting of cyprodinil, mepanipyrim, pyrimethanil;

[0041] C (20) Phenylurea fungicides, including pencycuron.

[0042] In a preferred embodiment, the present invention provides a method for preparing a synergistic composition, the composition comprising A) tolfenpyrad, B) diafenthiuron, C) at least one additional insecticide or fungicide selected from C1 - C20, and one or more inert excipients.

[0043] In one embodiment, the composition of the present invention comprises component (A) a pyrazole insecticide in the range of 1% to 15% w / w of the composition; (B) a thiourea insecticide in the range of 1% to 20% w / w of the composition; and (C) at least one pesticide in the range of 0.1% to 60% w / w of the composition.

[0044] In one embodiment, the composition of the present invention comprises component (A) tolfenpyrad, which accounts for 1% to 15%; component (B) diafenthiuron, which accounts for 1% to 20%; and component (C) at least one insecticide or fungicide selected from C1 to C20, which accounts for 0.1% to 60%.

[0045] In a preferred embodiment, the present invention provides a method for protecting plant propagation materials, plants, plant parts, and / or plant organs growing at a later time point from pest damage by applying the pesticidal composition of the present invention to the plant propagation materials.

[0046] In one embodiment, the composition of the present invention can be applied by any of the following methods:

[0047] · Foliar spraying / spraying

[0048] · Soil irrigation

[0049] · By drip irrigation

[0050] · Nursery application

[0051] · Mixing into the soil or other plant growth media in protected cultivation (greenhouse, screen house, plastic greenhouse).

[0052] Applying the composition of the present invention can improve the health status, yield, plant vigor, and quality of plants, and enhance their tolerance to biotic stress. The improvement of plant health status not only stems from the reduction of pest pressure, but also from the improvement of complex physiological and metabolic reactions, such as the activation of the plant's own natural defense system. Therefore, even in the absence of pest pressure, the health status of plants will be improved.

[0053] Therefore, in a preferred embodiment of the method according to the present invention, the health status of plants will be improved regardless of the presence or absence of biotic stress factors.

[0054] In a preferred embodiment of the present invention, the yield of plants treated according to the method for protecting plant propagation materials of the present invention will increase synergistically. The increase in yield includes an increase in plant weight, plant height, and biomass (such as higher total fresh weight (FW), higher grain yield, etc.).

[0055] In one embodiment, the composition of the present invention can enhance plant vigor, which includes improvements in plant growth, plant development, appearance, plant uprightness (reduction of plant lodging / reverse lodging), greener leaves, and reduced diseases.

[0056] In a preferred embodiment, the quality of plants treated according to the method of the present invention is synergistically improved, and the quality improvement includes improvements in the characteristics of plants or their products: better fruit color, better leaf color, stronger storage capacity, and higher processing performance of harvested products.

[0057] Another indicator of plant condition is the tolerance or resistance of plants to biotic stress factors. Biotic stress, especially long-term biotic stress, can have a harmful impact on plants. Biotic stress is caused by living organisms, while abiotic stress is caused by environmental extremes, for example.

[0058] In one embodiment of the present invention, the pesticide composition can be formulated into a suspension concentrate (SC), a suspoemulsion (SE), a water-dispersible granule (WDG or WG), a wettable powder (WP), and a dry flowable (DF).

[0059] In one embodiment of the present invention, the content range of the active ingredient in the composition is 10 w / w% to 60 w / w%; the content range of the inactive excipient in the composition is 40 w / w% to 90 w / w%.

[0060] In one embodiment of the present invention, the pesticide composition includes one or more inactive excipients selected from the following groups: surfactants, including dispersants, wetting agents, emulsifiers; antifreezes; defoamers; antibacterial agents; anti-settling agents or viscosity regulators or rheology modifiers; fillers; pH regulators.

[0061] The most commonly used surfactants include dispersants, wetting agents, emulsifiers, and are selected from the group consisting of: Ethylan NS500 LQ (polyalkoxylated butyl ether), sodium naphthalene sulfonate formaldehyde condensate, Agrilan 1015 (alkoxylated phosphate ester), Rhodacal N (sodium salt of naphthalene sulfonic acid formaldehyde condensate), sodium salt of alkyl naphthalene sulfonic acid formaldehyde condensate, sodium lignosulfonate, mixture of salts of condensation products of naphthalene sulfonic acid and benzenesulfonic acid, tri styryl phenol polyoxyethylene ether phosphate ester, fatty alcohol polyoxyethylene ether, alkyl polyoxyethylene ether, ethylene oxide - propylene oxide block copolymers (EO - PO block copolymers), acrylic acid graft copolymers or mixtures thereof, alkyl naphthalene sulfonates, ethoxylated derivatives of styrenated phenols, styrene acrylic copolymers, Lissapol BN200, Taurate - sodium N - methyl N Acyl, alkyl sulfonates, Geropon SC213 (potassium polycarboxylate), sodium dodecyl sulfate, Lissapol BN200 (anionic blend), Lissapol D (anionic blend), alkoxylated surfactants, sulfosuccinates, Rodacal 60BE (calcium salt of linear dodecylbenzene sulfonic acid in ethylhexanol solution), alkyl phenol ethoxylate, nonylphenol polyoxyethylene ether, octylphenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, lauryl myristyl alcohol polyoxyethylene ether, cetearyl alcohol polyoxyethylene ether, cetyl alcohol polyoxyethylene ether, stearyl alcohol polyoxyethylene ether, behenyl alcohol polyoxyethylene ether, fatty acid polyoxyethylene ether, stearic acid polyoxyethylene ether, oleic acid polyoxyethylene ether, coconut fatty acid polyoxyethylene ether, ethoxylated fatty alcohol phosphate esters, fatty alcohol phosphate polyoxyethylene ethers, polyethylene glycol stearate, fatty alcohol phosphate polyoxyethylene ethers, synthetic alcohol phosphate polyoxyethylene ethers, alkyl phenol sulfate polyoxyethylene ethers, fatty alcohol sulfate polyoxyethylene ethers, alkyl phenol polypropylene oxide ethers, fatty alcohol polypropylene oxide ethers, synthetic alcohol polypropylene oxide ethers, calcium salt of alkyl benzene sulfonic acid, TSP ethoxylate, fatty alcohol polyoxyethylene ether phosphate, naphthalene sulphonates condensate, phenol sulphonates condensate or mixtures thereof;

[0062] The antifreeze is selected from the group consisting of tri - hydroxyl propane, propylene glycol, glycerol, glycerin, ethylene glycol, propylene glycol methyl ether, diethylene glycol, dipropylene glycol, butylene glycol or mixtures thereof;

[0063] The defoamer is selected from the group including polydimethylsiloxane, 2-octanol, oleic acid, paraffin wax, amide wax, sulfonated oil, organic phosphate ester, silicone oil, mineral oil, alkyl polyacrylate, EO / PO-based defoamer (including polyethylene glycol, polypropylene glycol or their mixture);

[0064] The antibacterial agent is selected from the group including 1,2-benzisothiazol-3-(2H)-one, 1,2-benzisothiazolin-3-one, formaldehyde, 3-trimethoxysilylpropyl dimethyloctadecyl ammonium chloride, triclosan, trichlorocarbanilide, 0,10-oxybisphenoxarine (OBPA), propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, sodium p-hydroxybenzoate, methyl p-hydroxybenzoate, biocide containing sodium benzoate, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, p-hydroxybenzoate or their mixture;

[0065] The rheology modifier or anti-settling agent or viscosity regulator is selected from the group including xanthan gum, gum arabic, gum ghatti, gum tragacanth, guar gum, Aerosil, fumed silica, cellulose (such as methylcellulose, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxyethyl cellulose), polyacrylate, clay, polyamide, glue powder, polyacrylate, polyvinyl alcohol and polyethylene oxide or their mixture;

[0066] The pH regulator is selected from the group including: all buffer solutions, such as sodium hydroxide and dipotassium hydrogen phosphate solution, acetic acid and sodium acetate, ammonia water and ammonium chloride, citric acid, benzoic acid, salicylic acid, hydrochloric acid, phosphoric acid, sodium citrate, soda ash, calcium carbonate, acetic acid or their mixture;

[0067] The filler is selected from the group including china clay, lactose monohydrate, precipitated silica, corn starch, kaolin, ammonium sulfate, sodium citrate, diatomaceous earth, deionized (DM) water or their mixture.

[0068] In one embodiment, the crops and plants that can be processed by the present invention include selected genetically modified varieties or hybrid varieties or conventional varieties of rice, cotton, wheat, corn, sugarcane, soybeans, peanuts, sunflowers, mustard, rapeseed, castor beans, mung beans, black beans, chickpeas, red beans, horse beans, peas, cluster beans, eggplants, cabbages, cauliflowers, okra, onions, tomatoes, potatoes, peppers, garlic, cucumbers and melons, turnips, apples, bananas, citrus fruits, grapes, guavas, mangoes, papayas, pineapples, pomegranates, sapodillas, tea, coffee, turmeric, ginger, cumin, black pepper, moringa, coconuts, mint, roses, marigolds.

[0069] In one embodiment of the present invention, the pesticidal composition of the present invention can control harmful arthropods such as rice leafhopper (Nephotettix nigropictus), brown planthopper (Nilaparvata lugen), white-backed planthopper (rice whitebacked plant hopper), apple mealybug (Phenococcus aceris), black citrus aphid (Toxoptera aurantii), olive black scale (Saissetia oleae), cabbage aphid (Brevicoryne brassicae, Lipaphis erysimi), red scale (Aonidiella aurantii), citrus mealybug (Planococcus citri), cotton aphid (Aphis gossypii), cotton leafhopper (Amrasca biguttula), cotton mealybug (Planococcus spp. and Pseudococcus spp.), cotton stainer (Dysdercus suturellus), cotton whitefly (Bemisia tabaci), Rudbeckia aphid (Uroleucon spp.), grape mealybug (Pseudococcus maritimus), greenhouse whitefly (Trialeurodes vaporariorum spp.), papaya mealybug (Pracoccus marginatus), sugarcane mealybug (Saccharicoccus sacchari), potato aphid (Myzus persicae), potato leafhopper (Empoasca fabae), cotton whitefly (Bemisia tabaci), woolly apple aphid (Eriosoma lanigerum), yellow scale (Aonidiella citrine); Lepidoptera, armyworm (Mythimna unipuncta), striped stem borer (Chilo suppressalis), beet armyworm (Spodoptera exigua), black cutworm (Agrotis ipsilon), cotton bollworm (Helicoverpa spp.)、Trichoplusia ni, Cydia pomonella, Plutella xylostella, Pieris rapae, Pectinophora gossypiella, Diatraea saccharalis, Heliothis virescens, Helicoverpa zea, Scirpophaga incertulas, Earias vittella, Cnaphalocrocis medinalis, Sesamia spp., Spodoptera litura; Coleoptera, e.g., Amphicerus spp., Diabrotica balteata, Anthonomus grandis, Altica chalybea; Orthoptera, e.g., Gryllotalpa spp., Locusta spp., and Schistocerca spp.; from Thysanoptera, e.g., Frankliniella spp., Thrips palmi, Thrips tabaci, and Scirtothrips dorsalis; Hemiptera, e.g., Dysdercus spp., Leptocorisa spp.; Hymenoptera, e.g., Solenopsis spp.; Diptera, e.g., Antherigona soccata, Dacus spp., Liriomyza spp., Melanagromyza spp.; Acarina, e.g., Aceria mangiferae, Brevipalpus spp., Eriophyes spp., Oligonychus mangiferus, Oligonychus punicae, Panonychus citri, Panonychus ulmi, Polyphagotarsonemus latus, Tarsonemus spp.)、Two-spotted spider mite (Tetranychus urticae), Carmine spider mite (Tetranychus cinnabarinus).

[0070] The present invention can also prevent and control diseases, such as Albugo spp. (white rust), Alternaria spp. (alternaria leaf spot), Ascochyta spp., Blumeria spp., Botrytis cinerea (gray mold), Cercospora spp. (cercospora leaf spot), Cladosporium spp. (leaf mold), Claviceps purpurea (ergot disease), Helminthosporium spp. (brown spot of rice), Colletotrichum spp. (anthracnose), Corynespora cassiicola (leaf spot), Diaporthe spp. (pod blight), Drechslera spp. (brown spot), Elsinoe spp. (anthracnose of grape), Entyloma oryzae (leaf smut), Erysiphe spp. (powdery mildew), complex disease of cereal discoloration; Guignardia bidwellii (black rot of grape), Hemileia spp. (coffee rust), Macrophomina phaseolina (root and stem rot), Microsphaera diffusa (powdery mildew), Mycosphaerella spp., Mycosphaerella fijiensis (black leaf spot of banana), Peronospora spp. (downy mildew), Phakopsora pachyrhizi (rust of soybean), Phomopsis spp. (leaf spot), Physoderma maydis (brown spot of corn), Phytophthora spp. (late blight); Plasmodiophora brassicae (clubroot), Plasmopara spp. (downy mildew), Podosphaera spp. (powdery mildew); Pseudocercosporella herpotrichoides (eyespot of wheat), Puccinia spp. (rust), Pyricularia spp. (rice blast); Ramularia spp., Botrytis cinerea (gray mold); Rhizoctonia spp. (sheath blight); Sarocladium oryzae (sheath rot); Septoria spp. (Septoria leaf spot); Uncinula spp. (powdery mildew); Setospaeria spp. (leaf blight); Sphacelotheca spp. (smut); Sphaerotheca fuliginea (powdery mildew); Spongospora subterranea (powdery scab); Urocystis spp. (flag smut); Uromyces spp. (rust); Ustilago spp. (loose smut), Venturia spp. (scab).

[0071] Manufacturing method of the preparation of the present invention

[0072] Manufacturing method of suspension emulsion (SE)

[0073]

[0074]

[0075] Example 1: Suspension emulsion (SE) of 11% tolfenpyrad + 14.3% diafenthiuron + 5.3% bifenthrin

[0076] Preparation

[0077]

[0078] The SE preparation can be applied at the following doses:

[0079]

[0080] Manufacturing method of water dispersible granules (WG)

[0081]

[0082] Example 2: Water dispersible granules (WG) of 12.5% tolfenpyrad + 15% diafenthiuron + 2.5% dinotefuran

[0083] Preparation

[0084]

[0085] The WG preparation can be applied at this dose:

[0086]

[0087] Manufacturing method of suspension concentrate (SC)

[0088]

[0089]

[0090] Example 3: Suspension concentrate (SC) of 10.4% tolfenpyrad + 14.3% diafenthiuron + 3.3% hexythiazox

[0091] Preparation

[0092] Chemical composition Percentage (% w / w) Tolfenpyrad active ingredient 10.4 Pesticide Diafenthiuron active ingredient 14.3 Pesticide Hexythiazox active ingredient 3.3 Pesticide Ethoxylated derivative of styrenated phenol 2.0 Emulsifier Acrylic acid graft copolymer 1.5 Surfactant Sodium salt of alkyl naphthalene sulfonic acid formaldehyde condensate 3.0 Dispersant Silicone defoamer 0.5 Defoamer 1,2 - benzisothiazolin - 3 - one 0.1 Biocide Trihydroxypropane 10 Antifreeze Xanthan gum powder 0.20 Rheology modifier DM water Appropriate amount Filler Total 100.00

[0093] The SC formulation can be administered at this dose.

[0094]

[0095] Manufacturing method of wettable powder (WP)

[0096]

[0097] Example 4: Wettable powder (WP) preparation of 6.8% tolfenpyrad + 9.0% diafenthiuron + 4.3% pyraclostrobin

[0098] Ingredient Percentage (w / w) Tolfenpyrad technical 6.8 Pesticide Diafenthiuron technical 9.0 Pesticide Pyraclostrobin technical 4.3 Pesticide Alkyl naphthalene sulfonate 10 Dispersant Alkyl sulfonate 2 Wetting agent Precipitated silica 30 Filler China clay 37.9 Filler Total 100

[0099] The WP formulation can be administered at this dose.

[0100]

[0101] Manufacturing method of dry flowable (DF)

[0102]

[0103]

[0104] Example 5: Dry flowable (DF) preparation of 9% tolfenpyrad + 12% diafenthiuron + 9.0% tebuconazole

[0105] Ingredient Example 1 Tolfenpyrad 9.0 Pesticide Diafenthiuron 12.0 Pesticide Tebuconazole 9.0 Pesticide Mixture of salts of condensation products of naphthalene sulfonic acid and benzenesulfonic acid 12.0 Dispersant Sodium lignosulfonate 10.0 Disperse Silicone defoamer 2.00 Defoamer Corn starch 30 Filler China clay Appropriate amount Filler Total 100

[0106] The DF formulation can be administered at this dose.

[0107]

[0108] Those skilled in the art can modify the process for preparing the synergistic plant protection composition of the present invention accordingly based on the knowledge of manufacturing the formulation. However, all such changes and modifications are still covered by the scope of protection of the present invention.

[0109] The following formulations in the table below are manufactured using different excipients according to the present invention in accordance with the above manufacturing steps.

[0110] Table of preferred mixtures (Active ingredient A = tolfenpyrad; Active ingredient B = diafenthiuron)

[0111]

[0112]

[0113]

[0114] Biological Examples

[0115] The synergistic activity of the compositions of the present invention was studied through various biological experiments carried out in the field. In different series of experiments, the control effects on target pests and pathogenic diseases, the influence on crop greening, and the influence on yield were studied.

[0116] Field experiment method: The field trials were conducted in commercial farmlands in high-incidence areas of naturally occurring harmful arthropods and plant pathogenic diseases. The test site was located in Maharashtra state, India. The tests were carried out using conventional research methods. In the test fields, the crops were treated by standard foliar treatment methods according to the specified treatment methods and their dosages as described below. Using standard observation methods, the timely observation data of the test fields were recorded, including the control rates of insects and diseases, the influence on crop greening, and the influence on yield.

[0117] A synergistic effect exists as long as the action of the combination of active ingredients is greater than the sum of the actions of each component alone. Therefore, the synergistically effective amount or the effective amount of a synergistic composition or combination refers to the amount that exhibits higher insecticidal activity than the sum of the insecticidal activities of each individual component.

[0118] The synergistic effect was calculated using the method of Colby and Weeds (1967).

[0119] Colby formula

[0120] Expected efficacy (EE) = X + Y + Z - (XY + YZ + XZ) / 100 + (X * Y * Z) / 10000

[0121] Wherein,

[0122] E = the expected control percentage of a mixture of the specified dosages of three products A, B, and C.

[0123] X = the observed control percentage of product A.

[0124] Y = the observed control percentage of product B.

[0125] Z = the observed control percentage of product C.

[0126] When the combined observed disease control percentage (E) is greater than the expected percentage, it can be inferred that the combination has a synergistic effect. When the combined observed disease control percentage is equal to the expected percentage, only an additive effect can be inferred; while when the combined observed weed control percentage is lower than the expected percentage, it can be inferred that the combination has an antagonistic effect.

[0127] Ratio = Observed control % / Expected control %

[0128] A ratio of O / E > 1 implies observed synergy.

[0129] Field trials were conducted on the synergistic mixtures of tolfenpyrad + diafenthiuron + bifenthrin, tolfenpyrad + diafenthiuron + hexythiazox, tolfenpyrad + diafenthiuron + pyraclostrobin, and tolfenpyrad + diafenthiuron + tebuconazole of the present invention on cotton, soybean, and eggplant crops to evaluate their biocontrol effects against piercing-sucking arthropods and phytopathogenic diseases damaging the crops.

[0130] Using the following formula, the disease control percentage (PDI) was recorded 7 days and 15 days after application:

[0131]

[0132] Field trial 1 - Synergistic effect of the composition of the present invention - 11.0% tolfenpyrad + 14.3% diafenthiuron + bifenthrin 5.3% - SE and 12.5% tolfenpyrad + 15.0% diafenthiuron + 2.5% dinotefuran - WG

[0133] Field trials were conducted to test whether there is a synergistic effect when tolfenpyrad + diafenthiuron + bifenthrin is used alone and in combination in the form of a suspo-emulsion (SE), and when tolfenpyrad + diafenthiuron + dinotefuran is used alone and in combination in the form of a water-dispersible granule (WG) at the preferred mass ratio (w / w) of the present invention.

[0134] Crop: Cotton Treatment: 7 Plot size: 10x5 square meters Variety: RASI 558BT Number of replicates: 3 Row spacing: 90cm x 60cm Crop growth stage at spraying: Mid-flowering (75 days after sowing)

[0135] Location: Shirpur, Maharashtra

[0136] Application method: Foliar spraying using a sprayer equipped with a hollow cone nozzle

[0137] Agronomic measures: Fertilization, irrigation, intertillage, and weeding were carried out according to crop requirements.

[0138] Table 1: Synergistic activity against thrips

[0139]

[0140] # The values are the averages of three repetitions

[0141] Observation result : It can be seen from the field trial data in Table 1 that, compared with the products used alone and the untreated control group, the preferred formulation in the form of a suspo-emulsion of T1 - 11.0% tolfenpyrad + 14.3% diafenthiuron + 5.3% bifenthrin showed a synergistic effect in the control activity against thrips from the 5th day to the 15th day. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3 to T5).

[0142] It can be seen that, compared with the products used alone and the untreated control group, the preferred formulation in the form of a water-dispersible granule of T2 - 12.5% tolfenpyrad + 15.0% diafenthiuron + 2.5% dinotefuran also showed a synergistic effect in the control activity against thrips from the 5th day to the 15th day. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3, T4 and T6).

[0143] Although the preferred compositions T1 and T2 use fewer active ingredients, they showed better control activity against thrips on cotton.

[0144] Table 2: Effects of different treatments on the health and yield of cotton crops

[0145]

[0146] # The values are the averages of three repetitions, and values with different superscript letters are significantly different. The numbers in parentheses represent the percentage increase compared to the untreated group. The chlorophyll content (expressed as the measured SPAD value) will increase proportionally to the content of nitrogen (an important plant nutrient) in the leaves. For a specific plant variety, a higher SPAD value indicates a healthier plant.

[0147] Observation result : It can be seen from the field trial data in Table 2 that, compared with the single-drug treatment groups and the untreated control group of cotton crops, the preferred formulation in the form of a suspo-emulsion of T1 - 11.0% tolfenpyrad + 14.3% diafenthiuron + 5.3% bifenthrin showed significant improvement in crop health, yield and crop greening. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3 to T5).

[0148] It was observed that the total yield of cotton crops increased by about 17.7%. Further observation found that the combined insecticides of the present invention were at least about 3 times more effective than the crops treated with biocides alone. Although the preferred composition uses fewer active ingredients, it showed better effects in crop health, yield and crop greening.

[0149] It can be seen that, compared with the single-application treatment group and the untreated control group of soybean and cotton crops, the preferred formulation in the form of water-dispersible granules of T2 - 12.5% tolfenpyrad + 15.0% diafenthiuron + 2.5% dinotefuran showed significant improvement in terms of crop health, yield, and crop greening. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3, T4, and T6). Although the preferred composition uses a smaller number of active ingredients, it shows better effects in terms of crop health, yield, and crop greening.

[0150] It was observed that the total yield of cotton crops increased by approximately 18.8%. Further observation found that the combined insecticide of the present invention is at least about 3 times more effective than the crops treated with biocides alone. It was observed that the seed cotton yields (kg / ha) at harvest of T1 and T2 both increased by approximately 15% compared with the crops treated with biocides alone.

[0151] Regarding the greening effect, it is worth noting that the chlorophyll content of T1 and T2 increased from the 5th day to the 15th day. Compared with single-application treatment, the preferred combined insecticide is significantly effective in promoting crop greening.

[0152] Table 3: Antagonistic activity against thrips

[0153]

[0154] # Values are the average of three replicates, DAA - days after application

[0155] Observation result : In Table 3, the active ingredient concentration and dosage rate of treatment T1 - 0.72% tolfenpyrad + 0.94% diafenthiuron + 0.34% bifenthrin w / w (suspension emulsion) are not within the preferred range of the present invention.

[0156] In Table 3, the active ingredient concentration and dosage rate of treatment T2 - 0.90% tolfenpyrad + 0.92% diafenthiuron + 0.18% dinotefuran (water-dispersible granules) are not within the preferred range of the present invention.

[0157] It was observed that treatments T1 and T2 did not show any significant improvement in the control activity of cotton plants against thrips.

[0158] It can be concluded that when the SE formulation of tolfenpyrad + diafenthiuron + bifenthrin and the WG formulation of tolfenpyrad + diafenthiuron + dinotefuran exceed the preferred w / w ratio, they will not show a synergistic effect in controlling cotton thrips. The observed effect is antagonistic.

[0159] Field trial 2 - Synergistic effect of the composition of the present invention - 10.4% tolfenpyrad + 14.3% diafenthiuron + hexythiazox 3.3% - SC

[0160] Field trials were conducted to test whether there is a synergistic effect when tolfenpyrad + diafenthiuron + pyridaben are used alone and in combination in the form of a suspension concentrate (SC) at the preferred w / w ratios of the present invention. Crop: Eggplant Treatments: 5 Plot size: 10 x 5 square meters Variety: Manjiri Number of replicates: 4 Row spacing: 90 cm x 60 cm

[0161] Growth stage of the crop at the time of spraying: Mid-flowering stage (85 days after planting)

[0162] Location: Narayangaon, Maharashtra

[0163] Application method: Foliar spraying using a sprayer equipped with a hollow cone nozzle Agronomic measures: Fertilization, irrigation, intertillage, and weeding were carried out according to the crop requirements.

[0164] Table 4: Synergistic activity against whiteflies

[0165]

[0166] # Values are the average of four replicates, DAA - Days after application

[0167] Observation result : From the field trial data in Table 4, it can be seen that compared with the products used alone and the untreated control group, the preferred formulation T1 - a suspension concentrate of 10.4% tolfenpyrad + 14.3% diafenthiuron + 3.3% pyridaben showed a synergistic effect in the control activity against whiteflies from the 5th day to the 15th day. The dosage of the active ingredients in the preferred composition is less than that of the products T2 - T4 used alone. Although the preferred composition uses a smaller amount of active ingredients, it showed better control activity against whiteflies on eggplants.

[0168] Table 5: Synergistic activity against spider mites

[0169]

[0170] # Values are the average of four replicates, DAA - Days after application

[0171] Observation result : From the field trial data in Table 5, it can be seen that compared with the products used alone and the untreated control group, the preferred formulation T1 - a suspension concentrate of 10.4% tolfenpyrad + 14.3% diafenthiuron + 3.3% pyridaben showed a synergistic effect in the control activity against spider mites from the 5th day to the 15th day. The dosage of the active ingredients in the preferred composition is less than that of the products used alone. Although the preferred composition uses a smaller amount of active ingredients, it showed better control activity against spider mites on eggplants.

[0172] Table 6: Effects of Different Treatments on the Health Status and Yield of Eggplant Crops

[0173]

[0174]

[0175] # Values with different superscript letters are significantly different. The numbers in parentheses are the percentage increases compared to the untreated group. The chlorophyll content (expressed as the measured SPAD value) will increase proportionally with the nitrogen content (an important plant nutrient) in the leaves. For a specific plant variety, a higher SPAD value indicates a healthier plant.

[0176] Observation result : From the field trial data in Table 6, compared with the single-agent treatment group and the untreated control group of eggplant crops, the preferred formulation in the form of a suspension concentrate of T1 - 10.4% tolfenpyrad + 14.3% diafenthiuron + 3.3% hexythiazox showed significant improvement in crop health status, yield, and crop greening. The dosage of the active ingredients in the preferred composition is less than that of the products used alone. Although the preferred composition uses a smaller number of active ingredients, it shows better effects in terms of crop health status, yield, and crop greening.

[0177] It was observed that the total yield of the eggplant crops increased by approximately 12.3%. Further observation found that the combined insecticide of the present invention has an effect at least about 2 - 3 times higher than that of the crops treated with biocides alone.

[0178] Regarding the greening effect, it is worth noting that the chlorophyll increased from the 5th day to the 15th day. Compared with the single-agent treatment, the preferred combined insecticide has a significant effect in promoting crop greening.

[0179] Table 7: Antagonistic Activity against Whiteflies

[0180]

[0181]

[0182] # Values are the averages of four replicates, DAA - days after application

[0183] Observation result : In Table 7, the active ingredient concentration and dosage rate of treatment T1 (suspension concentrate) of 0.84% tolfenpyrad + 0.94% diafenthiuron + 0.22% hexythiazox are not within the preferred range of the present invention. It was observed that treatment T1 did not achieve any significant improvement in the control activity of whiteflies on eggplant plants.

[0184] It can be concluded that when the SC formulation of tolfenpyrad + diafenthiuron + hexythiazox exceeds the preferred w / w ratio, it will not exhibit a synergistic effect in controlling whiteflies on eggplants. The observed effect is antagonism.

[0185] Table 8: Antagonistic activity against spider mites

[0186]

[0187] # Values are the average of four replicates, DAA - days after application

[0188] Observation result : In Table 8, the active ingredient concentration and dosage rate of treatment T1 - 0.84% tolfenpyrad + 0.94% diafenthiuron + 0.22% hexythiazox (suspension concentrate) are not within the preferred range of the present invention. From the field trial data given in Table 8, it can be observed that treatment T1 did not achieve any significant improvement in the control activity against spider mites on eggplant plants.

[0189] It can be concluded that when the SC formulation of tolfenpyrad + diafenthiuron + hexythiazox exceeds the preferred w / w ratio, it will not exhibit a synergistic effect in controlling spider mites on eggplants. The observed effect is antagonism.

[0190] Field trial 3 - Synergistic effect of the composition of the present invention - 6.8% tolfenpyrad + 9.0% diafenthiuron + pyraclostrobin 4.3% - WP and 9.0% tolfenpyrad + 12.0% diafenthiuron + 9.0% tebuconazole - DF

[0191] Field trials were conducted to test whether there is a synergistic effect when tolfenpyrad + diafenthiuron + pyraclostrobin are used alone and in combination as a wettable powder (WP).

[0192] In addition, whether there is a synergistic effect when tolfenpyrad + diafenthiuron + tebuconazole are used alone and in combination in the form of a dry flowable (DF) at the preferred w / w ratio of the present invention was also tested. Crop: Soybean Treatment: 7 Plot size: 10x5 square meters Variety: JS 335 Number of replicates: 3 Row spacing: 45 cm

[0193] Growth stage of the crop at the time of spraying: Mid - flowering (45 days after sowing)

[0194] Location: Indore, Madhya Pradesh

[0195] Application method: Foliar spraying using a sprayer equipped with a hollow - cone nozzle

[0196] Agronomic measures: Fertilization, irrigation, inter - tillage, and weeding were carried out according to the crop requirements.

[0197] Table 9: Synergistic data against whiteflies

[0198]

[0199]

[0200] # The value is the average of four repetitions

[0201] Observation result : It can be seen from the field trial data in Table 9 that, compared with the products used alone and the untreated control group, the wettable powder form of the preferred formulation T1 - 6.8% tolfenpyrad + 9.0% diafenthiuron + 4.3% pyraclostrobin showed a synergistic effect in the control activity against whiteflies from the 5th day to the 15th day. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3 to T5).

[0202] It can be seen from the field trial data in Table 9 that, compared with the products used alone and the untreated control group, the dry flowable form of the preferred formulation T2 - 9.0% tolfenpyrad + 12.0% diafenthiuron + 9.0% tebuconazole showed a synergistic effect in the control activity against whiteflies from the 5th day to the 15th day. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3, T4 and T6).

[0203] It can be concluded that although the preferred compositions T1 and T2 use fewer active ingredients, they showed better control activity against whiteflies on soybeans.

[0204] Table 10: Synergistic activity against anthracnose

[0205]

[0206]

[0207] # The value is the average of three repetitions, and values with different superscript letters are significantly different

[0208] Observation result : It can be seen from the T1 field trial data in Table 10 that, compared with the products used alone and the untreated control group, the wettable powder form of the preferred formulation tolfenpyrad 6.8% + diafenthiuron 9.0% + pyraclostrobin 4.3% showed a synergistic effect in the control activity against anthracnose from the 7th day to the 15th day. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3 to T5).

[0209] As can be seen from Table 10, compared with the products used alone and the untreated control group, the wettable powder form of the preferred formulation T2 - 9.0% Tolfenpyrad + 12.0% Diafenthiuron + 9.0% Tebuconazole showed a synergistic effect in the control activity against anthracnose from the 7th day to the 15th day. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3, T4 and T6). Although the preferred composition uses a smaller number of active ingredients, it showed better control activity against anthracnose on soybeans.

[0210] Table 11: Effects of different treatments on the health status and yield of soybean crops

[0211]

[0212]

[0213] # Values are the average of three replicates, * Values with different superscript letters are significantly different

[0214] Observation result : From the field trial data in Table 11, compared with the single - drug treatment group and the untreated control group of soybean crops, the wettable powder form of the preferred formulation T1 - 6.8% Tolfenpyrad + 9.0% Diafenthiuron + 4.3% Pyraclostrobin showed significant improvement in crop health status, yield and crop regreening. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3 to T5). Although the preferred composition uses a smaller number of active ingredients, it showed better effects in crop health status, yield and crop regreening.

[0215] From the T2 field trial data in Table 11, compared with the single - drug treatment group and the untreated control group of soybean crops, the dry - flowable powder form of the preferred formulation 9.0% Tolfenpyrad + 12.0% Diafenthiuron + 9.0% Tebuconazole showed significant improvement in crop health status, yield and crop regreening. The dosage of the active ingredients in the preferred composition is less than that of the products used alone (T3, T4 and T6). Although the preferred composition uses a smaller number of active ingredients, it showed better effects in crop health status, yield and crop regreening.

[0216] It was further noted that the wettable powder form of the preferred formulation T2 - 6.8% Tolfenpyrad + 9.0% Diafenthiuron + 4.3% Pyraclostrobin increased the overall yield of soybean crops by approximately 14.04%. Further observation found that the combined insecticide of the present invention was at least about 4 times more effective than the crops treated with biocides alone.

[0217] In Table 11, it can be observed that the preferred formulation T2 - Tolfenpyrad 9.0% + Diafenthiuron 12.0% + Tebuconazole 9.0% in the dry suspension concentrate state increased the overall yield of soybean crops by approximately 13.12%. Further observation revealed that the combined insecticide of the present invention was at least about 4 times more effective compared to the crops treated with biocides alone.

[0218] Regarding the greening effect, as can be seen in Table 11, the preferred formulation T1 - Tolfenpyrad 6.8% + Diafenthiuron 9.0% + Pyraclostrobin 4.3% in wettable powder form and the preferred formulation T2 - Tolfenpyrad 9.0% + Diafenthiuron 12.0% + Tebuconazole 9.0% in dry suspension concentrate state showed an increase in chlorophyll content from the 5th day to the 15th day. Compared with the treatment with single agents, the preferred combined insecticide was significantly effective in promoting the greening of crops.

[0219] Table 12: Antagonistic activity against whiteflies on soybean crops

[0220]

[0221] # Values are the average of three replicates

[0222] Observation result : In Table 12, the active ingredient concentration and dosage rate of treatment T1 - Tolfenpyrad 0.78% + Diafenthiuron 0.94% + Pyraclostrobin 0.48% w / w (wettable powder) were not within the preferred range of the present invention. It was observed that treatment T1 did not achieve any significant improvement in the control activity of whiteflies on soybean crops.

[0223] In Table 12, the active ingredient concentration and dosage rate of treatment T2 - Tolfenpyrad 0.76% + Diafenthiuron 0.92% + Tebuconazole 0.87% (dry suspension concentrate) were not within the preferred range of the present invention. It was observed that treatment T2 did not achieve any significant improvement in the control activity of whiteflies on soybean crops.

[0224] It can be concluded that when the WP formulation of Tolfenpyrad + Diafenthiuron + Diafenthiuron and the DF formulation of Tolfenpyrad + Diafenthiuron + Tebuconazole exceed the preferred w / w ratio, they will not show a synergistic effect in controlling whiteflies on soybean crops. The observed effect is antagonistic.

[0225] Table 13: Antagonistic activity against anthracnose on soybean crops

[0226]

[0227]

[0228] # Values are the average of three replicates

[0229] Observation result: In Table 13, the active ingredient concentrations and dosage rates of the suspension concentrate formulation of Treatment T1 - 0.78% tolfenpyrad + 0.94% diafenthiuron + 0.48% pyraclostrobin w / w are not within the preferred range of the present invention. It can be observed from Table 13 that Treatment T1 did not achieve any significant improvement in the control activity of soybean crops against anthracnose.

[0230] It was further observed that the active ingredient concentrations and dosage rates of T2 - 0.76% tolfenpyrad + 0.92% diafenthiuron + 0.87% tebuconazole (dry flowable) are not within the preferred range of the present invention. It was observed that Treatment T2 did not achieve any significant improvement in the control activity of soybean crops against anthracnose.

[0231] It can be concluded that when the WP formulations of tolfenpyrad + diafenthiuron + pyraclostrobin and the DF formulations of tolfenpyrad + diafenthiuron + tebuconazole exceed the preferred w / w ratio, they will not exhibit a synergistic effect in controlling anthracnose in soybean crops. The observed effect is antagonistic.

[0232] Storage stability experimental data

[0233] A 14 - day stability test was conducted on the preferred compositions of the present invention. The data collected is presented in tabular form as follows.

[0234] Table 14 - Storage Stability - 11.0% tolfenpyrad + 14.3% diafenthiuron + 5.3% bifenthrin SE formulation

[0235]

[0236]

[0237] Observation result : Even at 7 days and 14 days, the degradation of the composition is minimal. The SE formulation type formulation [Example 1] of the composition 11.0% tolfenpyrad + 14.3% diafenthiuron + 5.3% bifenthrin showed stable characteristics within 14 days.

[0238] Table 15 - Storage Stability - 12.5% tolfenpyrad + 15.0% diafenthiuron + 2.5% dinotefuran WG formulation

[0239]

[0240] Observation result : Even at 7 days and 14 days, the degradation of the composition is minimal. The [Example 2] of the WG composition 12.5% tolfenpyrad + 15.0% diafenthiuron + 2.5% dinotefuran showed stable characteristics within 14 days.

[0241] Table 16 - Storage Stability - Tolfenpyrad 10.4% + Diafenthiuron 14.3% + Hexythiazox 3.3% SC formulation

[0242]

[0243] Observation result : Even at 7 days and 14 days, the degradation of the composition is minimal. The composition of tolfenpyrad 10.4% + diafenthiuron 14.3% + hexythiazox 3.3% SC formulation [Example 3] exhibits stable characteristics within 14 days.

[0244] Table 17 - Storage Stability - Tolfenpyrad 6.8% + Diafenthiuron 9.0% + Pyraclostrobin 4.3% WP formulation

[0245]

[0246]

[0247] Observation result : Even at 7 days and 14 days, the degradation of the composition is minimal. The composition of tolfenpyrad 6.8% + diafenthiuron 9.0% + pyraclostrobin 4.3% WP formulation [Example 4] exhibits stable characteristics within 14 days.

[0248] Table 18 - Storage Stability - Tolfenpyrad 9.0% + Diafenthiuron 12.0% + Tebuconazole 9.0% DF formulation

[0249]

[0250] Observation result : Even at 7 days and 14 days, the degradation of the composition is minimal. The composition of tolfenpyrad 9.0% + diafenthiuron 12.0% + tebuconazole 9.0% DF formulation [Example 5] exhibits stable characteristics within 14 days.

[0251] The synergistic pesticide composition of the present invention can exhibit excellent control effects on plant diseases at low doses and eliminates the concern of chemical damage to beneficial plants. Therefore, the present invention is extremely useful in the industry.

Claims

1. A synergistic pesticide composition for use on crops, comprising active ingredients: A) a pyrazole insecticide, B) a thiourea insecticide and C) at least one pesticide selected from the group consisting of insecticides or fungicides.

2. The composition according to claim 1, wherein (A) the pyrazole insecticide is present in the composition in the range of 1% to 15% w / w, (B) the thiourea insecticide is present in the composition in the range of 1% to 20% w / w, and (C) at least one pesticide is present in the composition in the range of 0.1% to 60% w / w.

3. The composition according to claim 1, wherein The pyrazole insecticide is tolfenpyrad, and the thiourea insecticide is diafenthiuron.

4. The composition according to claim 1, wherein The active ingredient (C) includes one or more of the following: C (1) Synthetic pyrethroids selected from the group consisting of bifenthrin, lambda-cyhalothrin, cypermethrin, deltamethrin, ethomethrin, cypermethrin; C (2) A neonicotinoid insecticide selected from the group consisting of acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, and thiamethoxam; C (3) A chord organ modulator insecticide selected from the group consisting of flonicamid or pymetrozine; C (4) Compounds of unknown or non-specific mode of action (mite growth inhibitors) selected from the group consisting of clofentezine, hexythiazox, etoxazole; C (5) Mitochondrial complex I electron transport inhibitor METI acaricide selected from the group consisting of fenazaquin, fenpyraclostrobin, pyrimidifen, and pyridaben; C (6) A lipid synthesis inhibitor, a tetronic acid derivative, selected from the group consisting of spirodiclofen and spiromesifen; C (7) A nicotinic acid receptor modulator selected from the group consisting of diamides and flubendiamide; C (8) Antibiotic fungicides selected from the group consisting of kasugamycin and polyoxin; C (9) A strobilurin fungicide selected from the group consisting of azoxystrobin, kresoxim-methyl, picoxystrobin, pyraclostrobin, trifloxystrobin; C (10) Aromatic fungicides, including chlorothalonil; C (11) Carbamate fungicides, including thiophanate-methyl; C (12) A triazole fungicide selected from the group consisting of cyproconazole, difenoconazole, epoxiconazole, flusilazole, hexaconazole, ipconazole, myclobutanil, penconazole, propiconazole, prothioconazole, tebuconazole, tetrafluconazole, and triadimefon; C (13) Copper fungicides selected from the group consisting of copper hydroxide, copper oxychloride, copper sulfate; C (14) A GABA-gated chloride channel allosteric modulator insecticide selected from the group consisting of fluoxetine and isoxathiapiprolin; C (15) sulfoxamine insecticides, including sulfoxaflor; C (16) Chitin synthesis inhibitor insecticides selected from the group consisting of bistrifluanuron, chlorfluazuron, diflubenzuron, flufenoxuron, flufenoxuron, hexaflumuron, lufenuron, flufenoxuron, perfluanid, flubendiamide, fluazifop-urea; C (17) Inorganic fungicides, including sulfur; C (18) dithiocarbamate fungicides, including propineb; C (19) Anilinopyrimidine fungicide selected from the group consisting of cyprodinil, pyraclostrobin, pyrimethanil; C (20) Phenylurea fungicides, including pencycuron.

5. The composition according to claim 1, wherein The combination of active ingredients is selected from the group comprising: i. (A) Tolfenpyrad, (B) Difenocarb, (C) Dinotefuran ii. (A) Tolfenpyrad, (B) Difenothiocarb, (C) Bifenthrin iii. (A) Tolfenpyrad, (B) Difenocarb, (C) Hexathiazolin iv. (A) Tolfenpyrad, (B) Diafenthiuron, (C) Pyraclostrobin v. (A) Tolfenpyrad, (B) Difenacarb, (C) Tebuconazole vi. (A) Tolfenpyrad, (B) Difenocarb, (C) Difenoconazole vii. (A) Tolfenpyrad, (B) Difenocarb, (C) Thiophanate-methyl viii. (A) Tolfenpyrad, (B) Difenacarb, (C) Fenpyrad ix. (A) Tolfenpyrad, (B) Difenocarb, (C) Copper oxychloride x. (A) Tolfenpyrad, (B) Difenocarb, (C) Chlorothalonil xi. (A) Tolfenpyrad, (B) Diafenthiuron, (C) Kasugamycin xii. (A) Tolfenpyrad, (B) Difenocarb, (C) Spiromefetzil xiii. (A) Tolfenpyrad, (B) Difenacarb, (C) Flufenacetyl urea xiv. (A) Tolfenpyrad, (B) Difenacarb, (C) Pymetrozine xv. (A) Tolfenpyrad, (B) Difenocarb, (C) Thiamethoxam xvi. (A) Tolfenpyrad, (B) Difenacarb, (C) Flonac xvii. (A) Tolfenpyrad, (B) Difenacarb, (C) Clothianidin xviii. (A) Tolfenpyrad, (B) Difenacarb, (C) Imidacloprid xix. (A) Tolfenpyrad, (B) Difenothiocarb, (C) Lambda-cyhalothrin xx. (A) Tolfenpyrad, (B) Difenothiocarb, (C) Cypermethrin xxi. (A) Tolfenpyrad, (B) Difenocarb, (C) Acetamiprid xxii. (A) Tolfenpyrad, (B) Difenocarb, (C) Ethioxazole xxiii. (A) Tolfenpyrad, (B) Difenocarb, (C) Proparg xxiv. (A) Tolfenpyrad, (B) Difenocarb, (C) Flubendiamide xxv. (A) Tolfenpyrad, (B) Difenacarb, (C) Fluoxetine xxvi. (A) Tolfenpyrad, (B) Difenacarb, (C) Isofenacil xxvii. (A) Tolfenpyrad, (B) Difenacarb, (C) Sulfoxaflor xxviii. (A) Tolfenpyrad, (B) Difenocarb, (C) Sulfur xxix. (A) Tolfenpyrad, (B) Difenocarb, (C) Propineb xxx. (A) Tolfenpyrad, (B) Difenocarb, (C) Myclobutanil xxxi. (A) Tolfenpyrad, (B) Difenacarb, (C) Pencycuron xxxii. (A) Tolfenpyrad, (B) Difenocarb, (C) Acynonapyr xxxiii. (A) Tolfenpyrad, (B) Diafenthiuron, (C) Azoxystrobin xxxiv. (A) Tolfenpyrad, (B) Difenacarb, (C) Trifloxystrobin xxxv.(A) Tolfenpyrad, (B) Butafenthiuron, (C) Fenazaquin.

6. The composition according to claim 1, wherein The composition comprises one or more inactive excipients selected from the group consisting of: surfactants, including dispersants, wetting agents, emulsifiers; antifreeze agents; defoamers; antimicrobial agents; anti-settling agents, viscosity modifiers, rheology modifiers; fillers; and pH adjusters.

7. The composition according to claim 6, wherein The active ingredient is present in the composition in a range of 10 w / w% to 60 w / w%; and the inactive excipient is present in the composition in a range of 40 w / w% to 90 w / w%.

8. The composition according to claim 6, wherein The dispersant, wetting agent, and emulsifier are selected from the group consisting of Ethylan NS500LQ (polyalkoxylated butyl ether), sodium naphthalenesulfonate formaldehyde condensate, Agrilan 1015 (alkoxylated phosphate ester), Rhodacal N (naphthalenesulfonic acid formaldehyde condensate sodium salt), alkylnaphthalenesulfonic acid formaldehyde condensate sodium salt, sodium lignin sulfonate, a mixture of salts of naphthalenesulfonic acid and benzenesulfonic acid condensation products, tristyrylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether, alkyl polyoxyethylene ether; ethylene oxide-propylene oxide block copolymer, acrylic acid graft copolymer or a mixture thereof, alkylnaphthalenesulfonate, ethoxylated derivatives of styrenated phenol, styrene acrylic acid copolymer, Lissapol BN200, sodium N-methyl-N-acyl taurate, alkyl sulfonate, Geropon SC213 (polycarboxylic acid potassium salt), sodium lauryl sulfate, Lissapol BN200 (anionic blend), Lissapol D (anionic blend), alkoxylated surfactants, sulfosuccinates, Rodacal 60BE (linear calcium salt of dodecylbenzene sulfonate in ethylhexanol solution), alkylphenol polyoxyethylene ethers, nonylphenol polyoxyethylene ethers, octylphenol polyoxyethylene ethers, fatty alcohol polyoxyethylene ethers, lauryl myristyl alcohol polyoxyethylene ethers, cetearyl alcohol polyoxyethylene ethers, hexadecyl alcohol polyoxyethylene ethers, stearyl alcohol polyoxyethylene ethers, behenyl alcohol polyoxyethylene ethers, fatty acid polyoxyethylene ethers, stearic acid polyoxyethylene ethers, oleic acid polyoxyethylene ethers, coconut fatty acid polyoxyethylene ethers, alkylphenol phosphoric acid Ester polyoxyethylene ether, fatty alcohol phosphate polyoxyethylene ether, polyethylene glycol stearate, fatty alcohol phosphate polyoxyethylene ether, synthetic alcohol phosphate polyoxyethylene ether, alkylphenol sulfate polyoxyethylene ether, fatty alcohol sulfate polyoxyethylene ether, alkylphenol polypropylene oxide ether, fatty alcohol polypropylene oxide ether, synthetic alcohol polypropylene oxide ether, alkylbenzene sulfonic acid calcium salt, TSP ethoxylate, fatty alcohol polyoxyethylene ether phosphate, naphthalenesulfonate condensate, phenolsulfonate condensate or a mixture thereof; The antifreeze agent is selected from the group consisting of trihydroxypropane, propylene glycol, glycerine, glycerol, ethylene glycol, propylene glycol methyl ether, diethylene glycol, dipropylene glycol, butylene glycol or a mixture thereof; The defoaming agent is selected from the group including polydimethylsiloxane, 2-octanol, oleic acid, paraffin, amide wax, sulfonated oil, organic phosphate, silicone oil, mineral oil, alkyl polyacrylate, EO / PO based defoaming agent (including polyethylene glycol, polypropylene glycol or mixture thereof); The antimicrobial agent is selected from the group consisting of 1,2-benzisothiazol-3-(2H)-one, 1,2-benzisothiazolin-3-one, formaldehyde, 3-trimethoxysilylpropyldimethyloctadecyl ammonium chloride, triclosan, trichlorotrioxide diphenol, 0,10-oxybisbenzoxazine (OBPA), propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, p-hydroxybenzoic acid sodium salt, methyl p-hydroxybenzoate, a biocide containing sodium benzoate, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, p-hydroxybenzoic acid esters or mixtures thereof; The rheology modifier or anti-settling agent or viscosity modifier is selected from the group consisting of xanthan gum, gum arabic, gum ghatti, gum tragacanth, guar gum, Aerosil, fumed silica, cellulose such as methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxyethyl cellulose, polyacrylate, clay, polyamide, gum powder, polyacrylate, polyvinyl alcohol and polyethylene oxide or mixtures thereof; The filler is selected from the group consisting of china clay, lactose monohydrate, precipitated silica, corn starch, kaolin, ammonium sulfate, sodium citrate, diatomaceous earth, deionized (DM) water or a mixture thereof; and The pH adjuster is selected from the group comprising: all buffer solutions, such as (sodium hydroxide and dipotassium hydrogen phosphate solution) acetic acid and sodium acetate, ammonia and ammonium chloride, citric acid, benzoic acid, salicylic acid, hydrochloric acid, phosphoric acid, sodium citrate, soda ash, calcium carbonate, acetic acid or a mixture thereof.

9. The synergistic composition according to claim 1, wherein: The dosage forms of the composition include suspension concentrate (SC), suspoemulsion (SE), water dispersible granules (WDG or WG), wettable powder (WP) and dry suspension concentrate (DF).

10. A method for preparing a synergistic pesticide composition for application to crops, the method comprising: The active ingredient is added to one or more inactive excipients in a synergistically effective concentration to form a mixture; wherein, The active ingredients include: A) a pyrazole insecticide, B) a thiourea insecticide, and C) at least one pesticide selected from the group consisting of insecticides or fungicides; and The inactive excipients include: a group of surfactants, including dispersants, wetting agents, emulsifiers; antifreeze agents; defoamers; antibacterial agents; anti-settling agents, viscosity regulators, rheology modifiers; fillers; and pH regulators.

11. The method according to claim 10, wherein: The pesticide composition prepared by the method has the following dosage forms: suspension concentrate (SC), suspoemulsion (SE), water dispersible granules (WDG or WG), wettable powder (WP) and dry suspension concentrate (DF).

12. The method according to claim 11, wherein: A method for preparing a suspoemulsion pesticide composition comprises: (a) preparing a solution by adding an excipient mixture including a rheology modifier, a biocide, and a defoaming agent to deionized water; (b) preparing an aqueous phase by mixing and homogenizing the pyrazole component (A) and the thiourea insecticide component (B) with an excipient mixture including an antifreeze agent, a dispersant, a biocide, a defoaming agent, and a pH adjuster; (c) preparing an organic phase by mixing component (C) with a dispersant and heating until a clear solution is observed, mixing an emulsifier into the solution and homogenizing; (d) adding the organic phase to the aqueous phase to form a mixture, and stirring the mixture under heating conditions; (e) adding a defoaming agent and deionized water to the mixture of step (d), and grinding the mixture; (f) adding a defoaming agent to the ground mixture of step (e); (g) adding the solution of step (a) to the mixture of step (f) to obtain a suspoemulsion composition.

13. The method according to claim 11, wherein: A method for preparing a water-dispersible granular pesticide composition comprises: (a) mixing a mixture of active ingredients (A), (B) and (C) with excipients including dispersants, wetting agents, defoaming agents and fillers; (b) homogenizing the mixture of step (a); (c) grinding the mixture of step (b) into powder; (d) adding deionized water to the powder to prepare a dough-like material; (e) extruding the dough-like material into granules; (f) drying the granules to form water dispersible granules.

14. The method according to claim 11, wherein: A method for preparing a suspension pesticide composition comprises: (a) preparing a solution by adding an excipient mixture including a rheology modifier, a biocide, and a defoaming agent to deionized water; (b) adding an emulsifier, an antifreeze agent and a dispersant into deionized water and homogenizing; (c) adding active ingredients (A), (B) and (C) to excipients and homogenizing to obtain a slurry; (d) adding a defoaming agent to the slurry of step (c) and grinding; (e) adding a defoaming agent to the ground mixture of step (d); (f) adding the solution of step (a) to the mixture of step (e) to obtain a suspension composition.

15. The method according to claim 11, wherein: A wettable powder pesticide composition is prepared, the method comprising: (a) preparing a mixture of active ingredients (A), (B) and (C) and excipients including dispersants, wetting agents and fillers; (b) uniformly blending the mixture of step (a); (c) grinding the mixture blended in step (b) into powder; (d) homogenizing the powder of step (c) to obtain a wettable powder composition.

16. The method according to claim 11, wherein: A dry suspension pesticide composition is prepared, the method comprising: (a) preparing a mixture of active ingredients (A), (B) and (C) and excipients including dispersants, defoamers and fillers; (b) uniformly blending the mixture of step (a); (c) grinding the blended mixture of step (b) and spray drying to obtain micronized particles of dry suspension.

17. The method according to claim 10, wherein: (A) the pyrazole insecticide is present in the composition in the range of 1% to 15% w / w, (B) the thiourea insecticide is present in the composition in the range of 1% to 20% w / w, and (C) at least one pesticide is present in the composition in the range of 0.1% to 60% w / w.

18. The method according to claim 10, wherein: The pyrazole insecticide is tolfenpyrad, and the thiourea insecticide is diafenthiuron.

19. The method according to claim 10, wherein: The active ingredient (C) includes one or more of the following: C (1) Synthetic pyrethroids selected from the group consisting of bifenthrin, lambda-cyhalothrin, cypermethrin, deltamethrin, ethomethrin, cypermethrin; C (2) A neonicotinoid insecticide selected from the group consisting of acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, and thiamethoxam; C (3) A chord organ modulator insecticide selected from the group consisting of flonicamid or pymetrozine; C (4) Compounds with unknown or non-specific modes of action (mite growth inhibitors) selected from the group consisting of clofentezine, hexythiazox, etoxazole; C (5) Mitochondrial complex I electron transport inhibitor METI acaricide selected from the group consisting of fenazaquin, fenpyraclostrobin, pyrimidifen, and pyridaben; C (6) A lipid synthesis inhibitor, a tetronic acid derivative, selected from the group consisting of spirodiclofen and spiromesifen; C (7) Nicotinic acid receptor modulators selected from the group consisting of diamides and flubendiamide; C (8) Antibiotic fungicides selected from the group consisting of kasugamycin and polyoxin; C (9) A strobilurin fungicide selected from the group consisting of azoxystrobin, kresoxim-methyl, picoxystrobin, pyraclostrobin, trifloxystrobin; C (10) Aromatic fungicides, including chlorothalonil; C (11) Carbamate fungicides, including thiophanate-methyl; C (12) A triazole fungicide selected from the group consisting of cyproconazole, difenoconazole, epoxiconazole, flusilazole, hexaconazole, ipconazole, myclobutanil, penconazole, propiconazole, prothioconazole, tebuconazole, tetrafluconazole, and triadimefon; C (13) Copper fungicides selected from the group consisting of copper hydroxide, copper oxychloride, copper sulfate; C (14) A GABA-gated chloride channel allosteric modulator insecticide selected from the group consisting of fluoxetine and isoxathiapiprolin; C (15) sulfoxamine insecticides, including sulfoxaflor; C (16) Chitin synthesis inhibitor insecticides selected from the group consisting of bistrifluanuron, chlorfluazuron, diflubenzuron, flufenoxuron, flufenoxuron, hexaflumuron, lufenuron, flufenoxuron, perfluanid, flubendiamide, fluazifop-urea; C (17) Inorganic fungicides, including sulfur; C (18) dithiocarbamate fungicides, including propineb; C (19) Anilinopyrimidine fungicide selected from the group consisting of cyprodinil, pyraclostrobin, pyrimethanil; C (20) Phenylurea fungicides, including pencycuron.

20. The method according to claim 10, wherein: The combination of active ingredients is selected from the group comprising: i. Tolfenpyrad, (B) diafenthiuron, (C) dinotefuran ii. (A) Tolfenpyrad, (B) Difenothiocarb, (C) Bifenthrin iii. (A) Tolfenpyrad, (B) Difenocarb, (C) Hexathiazolin iv. (A) Tolfenpyrad, (B) Diafenthiuron, (C) Pyraclostrobin v. (A) Tolfenpyrad, (B) Difenacarb, (C) Tebuconazole vi. (A) Tolfenpyrad, (B) Difenocarb, (C) Difenoconazole vii. (A) Tolfenpyrad, (B) Difenocarb, (C) Thiophanate-methyl viii. (A) Tolfenpyrad, (B) Difenacarb, (C) Fenpyrad ix. (A) Tolfenpyrad, (B) Difenocarb, (C) Copper oxychloride x. (A) Tolfenpyrad, (B) Difenocarb, (C) Chlorothalonil xi. (A) Tolfenpyrad, (B) Diafenthiuron, (C) Kasugamycin xii. (A) Tolfenpyrad, (B) Difenocarb, (C) Spiromefetzil xiii. (A) Tolfenpyrad, (B) Difenacarb, (C) Flufenacetyl urea xiv. (A) Tolfenpyrad, (B) Difenacarb, (C) Pymetrozine xv. (A) Tolfenpyrad, (B) Difenocarb, (C) Thiamethoxam xvi. (A) Tolfenpyrad, (B) Difenacarb, (C) Flonac xvii. (A) Tolfenpyrad, (B) Diafenthiuron, (C) Clothianidin xviii. (A) Tolfenpyrad, (B) Diafenthiuron, (C) Imidacloprid xix. (A) Tolfenpyrad, (B) Difenothiocarb, (C) Lambda-cyhalothrin xx. (A) Tolfenpyrad, (B) Difenothiocarb, (C) Cypermethrin xxi. (A) Tolfenpyrad, (B) Difenocarb, (C) Acetamiprid xxii.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Ethioxazole xxiii.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Propargite xxiv.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Flubendiamide xxv.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Fluoxathiapiprolin xxvi.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Isoxafenamide xxvii.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Flufenoxathiapiprolin xxviii.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Sulfur xxix.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Propineb xxx.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Myclobutanilxxxi.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Pencycuronxxxii.(A) Tolfenpyrad, (B) Diafenthiuron, (C) Acynonapyr xxxiii. (A) Tolfenpyrad, (B) Diafenthiuron, (C) Azoxystrobin xxxiv. (A) Tolfenpyrad, (B) Difenacarb, (C) Trifloxystrobin xxxv.(A) Tolfenpyrad, (B) Butafenthiuron, (C) Fenazaquin.

21. The method according to claim 10, wherein: The active ingredient is present in the composition in a range of 10 w / w% to 60 w / w%; and the inactive excipient is present in the composition in a range of 40 w / w% to 90 w / w%.

22. The method according to claim 10, wherein: The dispersant, wetting agent, and emulsifier are selected from the group consisting of Ethylan NS500LQ (polyalkoxylated butyl ether), sodium naphthalenesulfonate formaldehyde condensate, Agrilan 1015 (alkoxylated phosphate ester), Rhodacal N (naphthalenesulfonic acid formaldehyde condensate sodium salt), alkylnaphthalenesulfonic acid formaldehyde condensate sodium salt, sodium lignin sulfonate, a mixture of salts of naphthalenesulfonic acid and benzenesulfonic acid condensation products, tristyrylphenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether, alkyl polyoxyethylene ether; ethylene oxide-propylene oxide block copolymer, acrylic acid graft copolymer or a mixture thereof, alkylnaphthalenesulfonate, ethoxylated derivatives of styrenated phenol, styrene acrylic acid copolymer, Lissapol BN200, sodium N-methyl-N-acyl taurate, alkyl sulfonate, Geropon SC213 (polycarboxylic acid potassium salt), sodium lauryl sulfate, Lissapol BN200 (anionic blend), Lissapol D (anionic blend), alkoxylated surfactants, sulfosuccinates, Rodacal 60BE (linear calcium salt of dodecylbenzene sulfonate in ethylhexanol solution), alkylphenol polyoxyethylene ethers, nonylphenol polyoxyethylene ethers, octylphenol polyoxyethylene ethers, fatty alcohol polyoxyethylene ethers, lauryl myristyl alcohol polyoxyethylene ethers, cetearyl alcohol polyoxyethylene ethers, hexadecyl alcohol polyoxyethylene ethers, stearyl alcohol polyoxyethylene ethers, behenyl alcohol polyoxyethylene ethers, fatty acid polyoxyethylene ethers, stearic acid polyoxyethylene ethers, oleic acid polyoxyethylene ethers, coconut fatty acid polyoxyethylene ethers, alkylphenol phosphoric acid Ester polyoxyethylene ether, fatty alcohol phosphate polyoxyethylene ether, polyethylene glycol stearate, fatty alcohol phosphate polyoxyethylene ether, synthetic alcohol phosphate polyoxyethylene ether, alkylphenol sulfate polyoxyethylene ether, fatty alcohol sulfate polyoxyethylene ether, alkylphenol polypropylene oxide ether, fatty alcohol polypropylene oxide ether, synthetic alcohol polypropylene oxide ether, alkylbenzene sulfonic acid calcium salt, TSP ethoxylate, fatty alcohol polyoxyethylene ether phosphate, naphthalenesulfonate condensate, phenolsulfonate condensate or a mixture thereof; The antifreeze agent is selected from the group consisting of trihydroxypropane, propylene glycol, glycerine, glycerol, ethylene glycol, propylene glycol methyl ether, diethylene glycol, dipropylene glycol, butylene glycol or a mixture thereof; The defoaming agent is selected from the group including polydimethylsiloxane, 2-octanol, oleic acid, paraffin, amide wax, sulfonated oil, organic phosphate, silicone oil, mineral oil, alkyl polyacrylate, EO / PO based defoaming agent (including polyethylene glycol, polypropylene glycol or mixture thereof); The antimicrobial agent is selected from the group consisting of 1,2-benzisothiazol-3-(2H)-one, 1,2-benzisothiazolin-3-one, formaldehyde, 3-trimethoxysilylpropyldimethyloctadecyl ammonium chloride, triclosan, trichlorotrioxide diphenol, 0,10-oxybisbenzoxazine (OBPA), propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, p-hydroxybenzoic acid sodium salt, methyl p-hydroxybenzoate, a biocide containing sodium benzoate, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, p-hydroxybenzoic acid esters or mixtures thereof; The rheology modifier or anti-settling agent or viscosity modifier is selected from the group consisting of xanthan gum, gum arabic, gum ghatti, gum tragacanth, guar gum, Aerosil, fumed silica, cellulose such as methyl cellulose, hydroxyethyl cellulose, carboxymethyl cellulose, methyl hydroxyethyl cellulose, polyacrylate, clay, polyamide, gum powder, polyacrylate, polyvinyl alcohol and polyethylene oxide or mixtures thereof; The filler is selected from the group consisting of china clay, lactose monohydrate, precipitated silica, corn starch, kaolin, ammonium sulfate, sodium citrate, diatomaceous earth, deionized (DM) water or a mixture thereof; and The pH adjuster is selected from the group comprising: all buffer solutions, such as (sodium hydroxide and dipotassium hydrogen phosphate solution) acetic acid and sodium acetate, ammonia and ammonium chloride, citric acid, benzoic acid, salicylic acid, hydrochloric acid, phosphoric acid, sodium citrate, soda ash, calcium carbonate, acetic acid or a mixture thereof.

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