Hydrogen effervescent tablet and preparation method thereof

Abstract

The invention provides a hydrogen effervescent tablet and a preparation method thereof. The hydrogen effervescent tablet comprises the following components in percentage by mass: 7-15% of a hydrogen production matrix, 45-60% of a disintegrating agent, 0.5-2% of an adhesive and 40-50% of a filling agent, wherein the total mass percentage is 100%. The prepared hydrogen effervescent tablet has the advantages of being high in hydrogen content, short in disintegration time, low in moisture absorption mass fraction and the like, the hydrogen production and hydrogen locking capacity is good, the dissolution speed is high, the efficiency is high, the stability is good, and failure caused by moisture absorption is not likely to happen.

Description

Technical Field

[0001] The present invention belongs to the technical field of effervescent tablets, and particularly relates to a hydrogen effervescent tablet and a preparation method thereof. Background Art

[0002] Effervescent tablets are a new type of tablets that have been developed more in recent years. They use a mixture of organic acids and carbonates as disintegrants, and rapidly undergo a neutralization reaction in water to generate and release a large amount of carbon dioxide gas. They have the advantages of small volume, light weight, and easy to carry, and are suitable for the elderly and patients with swallowing difficulties. They are widely used in the research and development of domestic and foreign pharmaceutical preparations.

[0003] Effervescent tablets were initially applied in pharmaceuticals to help patients take them better and improve the drug effect. In addition to pharmaceutical effervescent tablets, in recent years, edible effervescent tablets, as a new type of solid beverage, have gradually entered the field of vision of consumers. The carbon dioxide released by the acid-base reaction after they are put into water can promote disintegration and fully release the nutritional components in the material particles. With the gradual improvement of the health awareness and health care awareness of the Chinese people, people increasingly value the nutritional and health care value of food. Therefore, how to apply effervescent tablets to products with edible and medicinal values still needs to be further explored.

[0004] Hydrogen has physical properties of being colorless, odorless, and non-toxic. It is the smallest gas molecule in nature, has an extremely low molecular weight, has a strong diffusion ability in the body, and can easily penetrate various biological membrane barriers of the body, so it can easily reach the internal structures of many biological macromolecules, such as any part of cells such as proteins, mitochondria, and fat molecules. With the continuous in-depth research on hydrogen medicine, there are reports in the prior art using hydrogen to treat in vitro inflammation, anti-aging and other problems, and currently good effects have been achieved. However, this method directly uses hydrogen gas as a treatment means, and the cost is relatively high. Therefore, how to reduce the cost to produce hydrogen from raw materials, and the hydrogen production content is high and the method is efficient and simple, is still one of the current research hotspots.

[0005] Aiming at the problems existing in the prior art, how to provide a hydrogen effervescent tablet with good hydrogen production and hydrogen locking ability, high efficiency, and good stability is an urgent problem to be solved by the present invention. Summary of the Invention

[0006] The purpose of the present invention is to provide a hydrogen effervescent tablet and a preparation method thereof to solve the problems raised in the above background art.

[0007] To achieve the above purpose, the present invention provides a hydrogen effervescent tablet, which is characterized in that, based on the total mass percentage of 100%, it contains the following components in mass percentage: 7-15% of hydrogen production matrix, 45-60% of disintegrant, 0.5-2% of binder, and 40-50% of filler;

[0008] The hydrogen production matrix is at least one of metallic elements or metal hydrides;

[0009] The binder is a composition of microcrystalline cellulose and modified microcrystalline cellulose.

[0010] As a further improvement, the metallic element is at least one of aluminum powder, magnesium powder, and zinc powder; the metal hydride is at least one of magnesium hydride, calcium hydride, and sodium borohydride.

[0011] To have a higher hydrogen content, preferably, the hydrogen production matrix is magnesium.

[0012] As a further improvement, the modified microcrystalline cellulose is prepared by reacting microcrystalline cellulose with stearic acid.

[0013] As a further improvement, the synthesis of the modified microcrystalline cellulose includes the following steps:

[0014] (1) Add microcrystalline cellulose and distilled water to a flask, stir and mix to obtain a suspension, and then add an organic solvent thereto, and perform ultrasonic treatment for 10 - 30 min;

[0015] (2) Add stearic acid to step (1), continue ultrasonic treatment for 10 - 30 min, and then stir and mix at 60 - 80 °C for 2 - 5 h. After the reaction ends, perform post-treatment to obtain the modified microcrystalline cellulose.

[0016] As a further improvement, the addition ratio of the microcrystalline cellulose to the modified microcrystalline cellulose is 2 - 5:1.

[0017] As a further improvement, the particle size of the microcrystalline cellulose is 50 - 100 μm, and the bulk density is 0.2 - 0.5 g / cm 3 .

[0018] As a further improvement, the disintegrant is at least one of citric acid, tartaric acid, fumaric acid, adipic acid, and malic acid; the filler is at least one of glucose, lactose, mannitol, maltodextrin, and starch.

[0019] To have a shorter disintegration time, preferably, the disintegrant is a complex of malic acid, tartaric acid, and adipic acid; to have a better filling effect, preferably, the filler is glucose.

[0020] As a further improvement, the hydrogen effervescent tablet further contains 0.5 - 2% of a desiccant, and the desiccant is at least one of anhydrous magnesium sulfate, anhydrous calcium chloride, anhydrous sodium sulfate, and anhydrous calcium sulfate.

[0021] To have a better drying effect, preferably, the desiccant is anhydrous magnesium sulfate.

[0022] The present invention provides a method for preparing a hydrogen bubble effervescent tablet, which is characterized by comprising the following steps:

[0023] (1) Mixing the hydrogen-generating precursor and the disintegrating agent according to mass percentage;

[0024] (2) The binder and filler are mixed and dried, and then added to step (1), sieved, and granulated to obtain a hydrogen bubble tablet.

[0025] The present invention also provides a method for preparing a hydrogen bubble effervescent tablet, which is characterized by comprising the following steps:

[0026] (1) Mixing the hydrogen-generating precursor and the disintegrating agent according to mass percentage;

[0027] (2) The binder, filler and desiccant are mixed and dried, and then added to the mixture in step (1), sieved, and granulated to obtain a hydrogen bubble tablet.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] The invention provides a hydrogen bubble vapour tablet and a preparation method thereof, so that the prepared hydrogen bubble vapour tablet has a higher hydrogen content, indicating that the hydrogen production and hydrogen locking capabilities are better, has a shorter disintegration time, indicating that the hydrogen bubble vapour tablet dissolves faster and has a higher efficiency, and has a lower moisture absorption mass fraction, indicating that the tablet has good stability and is not prone to moisture absorption and failure. DETAILED DESCRIPTION

[0030] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, but not to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0031] In the following examples, except for modified microcrystalline cellulose, the other compound monomers and related reagents used can be purchased from the market, among which microcrystalline cellulose was purchased from Shanghai Linchen Pharmaceutical Technology Co., Ltd. with model number KG-802, and glucose was purchased from Guangzhou Tianheng Technology New Materials Co., Ltd. with model number 225.

[0032] The synthesis of modified microcrystalline cellulose comprises the following steps:

[0033] (1) 4 g of microcrystalline cellulose and 40 mL of distilled water were added to a flask and stirred to obtain a suspension, and then 60 mL of anhydrous ethanol was added thereto and ultrasonically treated for 30 min;

[0034] (2) Add 4 g of stearic acid to step (1), continue ultrasonic treatment for 30 min, then stir and mix at 80 °C for 4 h. After the reaction is completed, centrifuge the solution with a refrigerated high-speed centrifuge, wash the precipitate with absolute ethanol, and finally dry it in a blast dryer at 50 °C for 12 hours to obtain modified microcrystalline cellulose.

[0035] The preparation methods of Examples 1-2 and Comparative Examples 1-3 include the following steps:

[0036] (1) Mix the hydrogen production matrix and disintegrant according to mass percentage;

[0037] (2) Mix the binder and filler and dry them at 50 °C, then add them to step (1), sieve through a 100-mesh sieve, and press and granulate to obtain a hydrogen effervescent tablet.

[0038] The preparation method of Example 3 includes the following steps:

[0039] (1) Mix the hydrogen production matrix and disintegrant according to mass percentage;

[0040] (2) Mix the binder, filler, and desiccant and dry them at 50 °C, then add them to step (1), sieve through a 100-mesh sieve, and press and granulate to obtain a hydrogen effervescent tablet.

[0041] The components and contents used in Examples 1-3 and Comparative Examples 1-3 are shown in Table 1 below:

[0042] Table 1

[0043]

[0044]

[0045] Perform hydrogen content, disintegration time, and stability tests on the hydrogen effervescent tablets prepared in Examples 1-3 and Comparative Examples 1-3. Among them, the weight of the effervescent tablet is 0.7 g, and the test methods are as follows:

[0046] Hydrogen content: Add the test sample to 100 mL of water, let it stand for 4 min, and use a hydrogen-rich test pen of model CT-8023 / CT-8023L to test the hydrogen concentration in the water;

[0047] Disintegration time: Put the test samples into test tubes containing 10 mL of pure water respectively, start timing, and shake the test tubes at the same time. Stop timing when the effervescent tablet is completely dissolved. This time is recorded as the disintegration time. Repeat 3 times and take the average value;

[0048] Stability test: Accurately weigh the test sample and place it in an environment with temperatures of 25°C and 40°C and a relative air humidity of 70% for 24 hours, then weigh it. Calculate the moisture absorption mass fraction; Moisture absorption mass fraction = (mass after moisture absorption - mass before moisture absorption) / mass before moisture absorption × 100%.

[0049] The test results are shown in Table 2 as follows:

[0050] Table 2

[0051]

[0052]

[0053] It can be seen from Example 2 and Comparative Examples 1-2 in Table 2 that compared with the hydrogen effervescent tablets prepared by using only microcrystalline cellulose or only modified microcrystalline cellulose as the binder, when using the composition of microcrystalline cellulose and modified microcrystalline cellulose as the binder, the prepared hydrogen effervescent tablets have a higher hydrogen content, a shorter disintegration time and a lower moisture absorption mass fraction, indicating that the hydrogen effervescent tablets have better hydrogen production and hydrogen locking capabilities, are not easily hygroscopic, and have stable performance.

[0054] It can be seen from Example 2 and Comparative Example 3 that when the ratio of the addition amounts of microcrystalline cellulose and modified microcrystalline cellulose is within a suitable range, the prepared hydrogen effervescent tablets have a higher hydrogen content, a shorter disintegration time and a lower moisture absorption mass fraction, indicating that the effervescent tablets have better binding performance, higher compactness between components, are not easily hygroscopic, and have stable performance, thus improving the hydrogen production and hydrogen locking capabilities.

[0055] It can be seen from the test results of Examples 1-3 that a kind of hydrogen effervescent tablet prepared by the preparation method provided by the present invention has a higher hydrogen content, indicating better hydrogen production and hydrogen locking capabilities, has a shorter disintegration time, indicating that the hydrogen effervescent tablet dissolves faster and has high efficiency, and has a lower moisture absorption mass fraction, indicating good stability and not being easily hygroscopic and causing failure.

[0056] The above embodiments are only used to illustrate the technical concept and characteristics of the present invention, and their purpose is to enable those who are familiar with this technology to understand the content of the present invention and implement it, and it cannot be used to limit the protection scope of the present invention. All equivalent changes or modifications made according to the spirit and essence of the present invention should be covered within the protection scope of the present invention.

Claims

1. A hydrogen bubble steaming sheet, characterized in that: The hydrogen bubble effervescent tablet comprises the following components in percentage by weight, based on the total weight percentage being 100%: 7-15% of a hydrogen-generating matrix, 45-60% of a disintegrant, 0.5-2% of a binder, and 40-50% of a filler; The hydrogen production matrix is ​​at least one of a metal element or a metal hydride; The binder is a combination of microcrystalline cellulose and modified microcrystalline cellulose.

2. A hydrogen gas bubble sheet according to claim 1, characterized in that: The metal element is at least one of aluminum powder, magnesium powder and zinc powder; the metal hydride is at least one of magnesium hydride, calcium hydride and sodium borohydride.

3. The hydrogen bubble steaming sheet according to claim 1, characterized in that: The modified microcrystalline cellulose is prepared by reacting microcrystalline cellulose and stearic acid.

4. The hydrogen bubble steaming sheet according to claim 1, characterized in that: The synthesis of the modified microcrystalline cellulose comprises the following steps: (1) adding microcrystalline cellulose and distilled water into a flask and stirring to obtain a suspension, then adding an organic solvent thereto and ultrasonically treating for 10-30 min; (2) adding stearic acid to step (1), continuing ultrasonic treatment for 10-30 min, then stirring and mixing at 60-80° C. for 2-5 h, completing the reaction, and post-treating to obtain modified microcrystalline cellulose.

5. The hydrogen bubble steaming sheet according to claim 1, characterized in that: The addition ratio of the microcrystalline cellulose to the modified microcrystalline cellulose is 2-5:

1.

6. The hydrogen bubble steaming sheet according to claim 1, characterized in that: The particle size of the microcrystalline cellulose is 50-100 μm, and the bulk density is 0.2-0.5 g / cm 3 .

7. The hydrogen bubble steaming sheet according to claim 1, characterized in that: The disintegrant is at least one of citric acid, tartaric acid, fumaric acid, adipic acid and malic acid; the filler is at least one of glucose, lactose, mannitol, maltodextrin and starch.

8. The hydrogen bubble steaming sheet according to claim 1, characterized in that: The hydrogen bubble vaporizing tablet further comprises 0.5-2% of a desiccant, wherein the desiccant is at least one of anhydrous magnesium sulfate, anhydrous calcium chloride, anhydrous sodium sulfate and anhydrous calcium sulfate.

9. The method for preparing a hydrogen gas bubble tablet according to any one of claims 1 to 7, characterized in that: The following steps are involved: (1) Mixing the hydrogen-generating precursor and the disintegrating agent according to mass percentage; (2) The binder and filler are mixed and dried, and then added to step (1), sieved, and granulated to obtain a hydrogen bubble tablet.

10. The method for preparing a hydrogen gas bubble sheet according to claim 8, characterized in that: The following steps are involved: (1) Mixing the hydrogen-generating precursor and the disintegrating agent according to mass percentage; (2) The binder, filler and desiccant are mixed and dried, and then added to the mixture in step (1), sieved, and granulated to obtain a hydrogen bubble tablet.

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