Traditional Chinese medicine composition and application thereof in preparation of medicine for preventing and / or treating insomnia

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition and application thereof in preparation of medicines for preventing and / or treating insomnia. The traditional Chinese medicine composition comprises the following traditional Chinese medicine components: honey-fried licorice roots, malt, Chinese dates, lily bulbs, lotus seeds, longan aril, spina date seeds, hawthorn fruits and kudzuvine roots. The traditional Chinese medicine composition further comprises fructus gardeniae, raw oyster shells and peach kernels. Researches show that the composition has a good effect of preventing and / or treating insomnia; therefore, the application of the compound in preparing the medicine for preventing and / or treating insomnia has important application value.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition and its application in the preparation of a drug for preventing and / or treating insomnia. Background Art

[0002] Insomnia is one of the most common forms of sleep disorders, characterized by frequent and persistent difficulty in falling asleep or maintaining sleep. Good sleep is essential for people to participate in various activities. With the development of society, the pace of life and work pressure of people have increased, and the incidence of insomnia is also rising and showing a trend of younger age.

[0003] Currently, the clinical treatment of insomnia mainly includes three methods: traditional Chinese medicine treatment, sedative-hypnotic drug treatment, and cognitive behavioral therapy. Insomnia cognitive therapy has not been widely applied in China due to reasons such as long treatment cycle, slow onset of effect, and high cost. Although sedative-hypnotic drugs have a relatively fast onset of effect and convenient treatment, they may also cause a series of adverse reactions such as drowsiness, delirium, behavioral disorders, and drug addiction. Traditional Chinese medicine has a long history and unique advantages in the treatment of insomnia, which can be traced back to the diagnosis and treatment of diseases such as "restless sleep" and "inability to close eyes" in "Huangdi Neijing". Many traditional Chinese medicine classics also record classic prescriptions for treating insomnia. The theory of traditional Chinese medicine believes that insomnia is caused by the imbalance of yin and yang, mostly caused by exogenous factors, internal injuries, diet, long-term illness, or congenital constitution. Traditional Chinese medicine summarizes insomnia into 9 categories according to the pathogenesis, such as liver depression transforming into fire, yin deficiency and fire hyperactivity, phlegm-heat disturbing internally, heart-kidney disharmony, heart-spleen deficiency, heart-gallbladder qi deficiency, stomach qi disharmony, heart fire flaming, and blood stasis obstruction. Traditional Chinese medicine treatment pays attention to the overall concept, balances yin and yang in the body through syndrome differentiation and treatment, and restores the normal waking and sleeping rhythm.

[0004] In summary, providing a traditional Chinese medicine with the function of preventing and / or treating insomnia has the application value of traditional Chinese medicine. Summary of the Invention

[0005] In order to overcome at least one technical problem existing in the prior art, the present invention provides a traditional Chinese medicine composition and its application in the preparation of a drug for preventing and / or treating insomnia.

[0006] The present invention first provides a traditional Chinese medicine composition, which comprises the following traditional Chinese medicine components: roasted licorice, malt, jujube, lily, lotus seed, longan aril, wild jujube seed, hawthorn, and kudzu root.

[0007] The inventor found in the research that a traditional Chinese medicine composition containing roasted licorice, malt, jujube, lily, lotus seed, longan aril,

[0008] wild jujube seed,

[0009] hawthorn, and kudzu root has a good effect on preventing and / or treating insomnia.

[0010] Preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0011] Roasted Licorice Root 5 - 40 parts, Fructus Hordei Germinatus 5 - 30 parts, Fructus Jujubae 5 - 30 parts, Bulbus Lilii 5 - 30 parts, Semen Nelumbinis 10 - 30 parts, Arillus Longan 5 - 30 parts, Semen Ziziphi Spinosae 5 - 30 parts, Fructus Crataegi 5 - 20 parts, Radix Puerariae 5 - 20 parts.

[0012] More preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0013] Roasted Licorice Root 10 - 30 parts, Fructus Hordei Germinatus 5 - 20 parts, Fructus Jujubae 5 - 20 parts, Bulbus Lilii 5 - 20 parts, Semen Nelumbinis 10 - 30 parts, Arillus Longan 5 - 20 parts, Semen Ziziphi Spinosae 10 - 30 parts, Fructus Crataegi 5 - 20 parts, Radix Puerariae 5 - 20 parts.

[0014] Most preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0015] Roasted Licorice Root 15 parts, Fructus Hordei Germinatus 10 parts, Fructus Jujubae 10 parts, Bulbus Lilii 10 parts, Semen Nelumbinis 15 parts, Arillus Longan 10 parts, Semen Ziziphi Spinosae 15 parts, Fructus Crataegi 10 parts, Radix Puerariae 10 parts;

[0016] or Roasted Licorice Root 10 parts, Fructus Hordei Germinatus 5 parts, Fructus Jujubae 5 parts, Bulbus Lilii 5 parts, Semen Nelumbinis 10 parts, Arillus Longan 5 parts, Semen Ziziphi Spinosae 10 parts, Fructus Crataegi 5 parts, Radix Puerariae 5 parts;

[0017] or Roasted Licorice Root 20 parts, Fructus Hordei Germinatus 15 parts, Fructus Jujubae 15 parts, Bulbus Lilii 15 parts, Semen Nelumbinis 20 parts, Arillus Longan 15 parts, Semen Ziziphi Spinosae 20 parts, Fructus Crataegi 20 parts, Radix Puerariae 20 parts.

[0018] More preferably, the traditional Chinese medicine composition further comprises Gardenia Fruit, Raw Oyster and Peach Kernel.

[0019] The inventor further found in the research that adding Gardenia Fruit, Raw Oyster and Peach Kernel to the traditional Chinese medicine composition containing Roasted Licorice Root, Fructus Hordei Germinatus, Fructus Jujubae, Bulbus Lilii, Semen Nelumbinis,

[0020] Arillus Longan,

[0021] Semen Ziziphi Spinosae, Fructus Crataegi and Radix Puerariae can further significantly improve the preventive and / or therapeutic effect of the traditional Chinese medicine composition on insomnia; making the traditional Chinese medicine composition have an excellent preventive and / or therapeutic effect on insomnia.

[0022] The inventor also found in further research that in the traditional Chinese medicine composition containing Roasted Licorice Root, Fructus Hordei Germinatus, Fructus Jujubae, Bulbus Lilii, Semen Nelumbinis, Arillus Longan

[0023] In the traditional Chinese medicine composition of meat, semen ziziphi spinosae, hawthorn and pueraria lobata, gardenia jasminoides, raw oyster and peach kernel must be further added simultaneously to further significantly enhance the preventive and / or therapeutic effect on insomnia of the traditional Chinese medicine composition; however, merely adding a single one of gardenia jasminoides, raw oyster or peach kernel cannot further significantly enhance the preventive and / or therapeutic effect on insomnia of the traditional Chinese medicine composition. Adding gardenia jasminoides, raw oyster and peach kernel simultaneously to the traditional Chinese medicine composition containing roasted licorice root, malt, Chinese date, lily, lotus seed, longan aril, semen ziziphi spinosae, hawthorn and pueraria lobata can synergistically enhance the preventive and / or therapeutic effect on liver injury of the composition.

[0024] More preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0025] Roasted licorice root 5-40 parts, malt 5-30 parts, Chinese date 5-30 parts, lily 5-30 parts, lotus seed 10-30 parts, longan aril 5-30 parts, semen ziziphi spinosae 5-30 parts, gardenia jasminoides 5-60 parts, raw oyster 5-20 parts, peach kernel 5-20 parts, hawthorn 5-20 parts, pueraria lobata 5-20 parts.

[0026] Even more preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0027] Roasted licorice root 10-30 parts, malt 5-20 parts, Chinese date 5-20 parts, lily 5-20 parts, lotus seed 10-30 parts, longan aril 5-20 parts, semen ziziphi spinosae 10-30 parts, gardenia jasminoides 10-40 parts, raw oyster 5-20 parts, peach kernel 5-20 parts, hawthorn 5-20 parts, pueraria lobata 5-20 parts.

[0028] Most preferably, the traditional Chinese medicine composition comprises the following traditional Chinese medicine components in parts by weight:

[0029] Roasted licorice root 15 parts, malt 10 parts, Chinese date 10 parts, lily 10 parts, lotus seed 15 parts, longan aril 10 parts, semen ziziphi spinosae 15 parts, gardenia jasminoides 30 parts, raw oyster 10 parts, peach kernel 10 parts, hawthorn 10 parts, pueraria lobata 10 parts;

[0030] Or, roasted licorice root 10 parts, malt 5 parts, Chinese date 5 parts, lily 5 parts, lotus seed 10 parts, longan aril 5 parts, semen ziziphi spinosae 10 parts, gardenia jasminoides 20 parts, raw oyster 5 parts, peach kernel 5 parts, hawthorn 5 parts, pueraria lobata 5 parts;

[0031] Or, roasted licorice root 20 parts, malt 15 parts, Chinese date 15 parts, lily 15 parts, lotus seed 20 parts, longan aril 15 parts, semen ziziphi spinosae 20 parts, gardenia jasminoides 60 parts, raw oyster 20 parts, peach kernel 20 parts, hawthorn 20 parts, pueraria lobata 20 parts.

[0032] The present invention also provides an application of the above traditional Chinese medicine composition in the preparation of a drug for preventing and / or treating insomnia.

[0035] Preferably, the drug uses the extract or extract prepared from the above traditional Chinese medicine composition as the active ingredient.

[0036] Preferably, the extract is prepared by the following method:

[0037] Extract the above traditional Chinese medicine composition with a solvent to obtain the extract.

[0038] Preferably, the extract is prepared by the following method:

[0039] Extract the above traditional Chinese medicine composition with a solvent to obtain the extract; concentrate and dry the extract to obtain the extract.

[0040] Preferably, the solvent is water, alcohol or an aqueous solution of alcohol.

[0041] Preferably, the alcohol is ethanol or methanol.

[0042] Preferably, the extraction is heating and decocting, and the decocting time is 1 - 3h.

[0043] Preferably, the extraction refers to heating and reflux extraction, and the extraction time is 1 - 3h.

[0044] Preferably, the weight dosage of the solvent is 5 - 15 times the total weight of the traditional Chinese medicine raw materials.

[0045] Preferably, the drug dosage form is granules, capsules, ointments, tablets, concentrated pills or oral liquid preparations.

[0046] Beneficial effects: The present invention provides a brand-new traditional Chinese medicine composition. Research shows that this composition has

[0047] a good effect in preventing and / or treating insomnia; therefore, using it to prepare drugs for preventing and / or treating insomnia has important application value.

[0048] In the optimal formula of the present invention, licorice, malt, and Chinese date are used as the "sovereign herbs", implying the famous traditional Chinese medicine formula for relieving depression, "Gancao Dazao Decoction". This formula nourishes the heart and soothes the mind, relieves the liver and eases urgency, and treats "Zangzao syndrome", which is manifested as emotional restlessness, insomnia, crying sadly from time to time, or mood swings, abnormal speech and behavior, and other emotional diseases. Lily, lotus seed, and oyster are used as assistants. Lily enters the heart meridian, can nourish yin and clear the heart, and soothe the mind. It is the main herb for treating "Lily disease" with heart yin consumption and restlessness of the mind in "Synopsis of the Golden Chamber". Lotus seed nourishes the heart blood, benefits the kidney qi, connects the heart and kidney, and soothes the mind. Oyster is salty, cold, and heavy in nature, with the effect of suppressing the hyperactive mind and calming the nerves, treating restlessness of the mind, insomnia, and dreaminess. Longan aril, wild jujube seed, and gardenia fruit jointly assist in calming the nerves. Longan aril nourishes the heart and spleen, and nourishes blood and soothes the mind; wild jujube seed nourishes the heart yin, benefits the liver blood, and soothes the mind; gardenia fruit purges heart fire and relieves vexation and soothes the mind. Peach kernel, hawthorn, and kudzu root promote blood circulation and remove blood stasis to dredge the meridians. Peach kernel enters the heart and liver meridians, and is good at dredging blood stasis; hawthorn enters the liver meridian, can promote qi and blood circulation, activate blood circulation and remove blood stasis, and modern research shows that it can dilate the coronary artery and increase coronary blood flow; kudzu root promotes the rising of yang qi, and modern research shows that it can dilate coronary blood vessels and cerebral blood vessels, increase coronary blood flow and cerebral blood flow, and improve cerebral blood supply, thus helping to soothe the mind and relieve depression. In summary, using it to treat insomnia has very good effects. Detailed implementation manners

[0049] The following specific examples are used to further explain the present invention, but the examples do not limit the present invention in any form.

[0050] Example 1 Traditional Chinese medicine composition

[0051] Take 15 parts of roasted licorice, 10 parts of malt, 10 parts of Chinese date, 10 parts of lily, 15 parts of lotus seed, 10 parts of longan aril, 15 parts of wild jujube seed, 10 parts of hawthorn, and 10 parts of kudzu root, and mix them evenly to obtain the traditional Chinese medicine composition.

[0052] The "parts" mentioned in this example, as well as the following examples and comparative examples, refer to "parts by weight".

[0053] Example 2 Traditional Chinese medicine composition

[0054] Take 10 parts of roasted licorice, 5 parts of malt, 5 parts of Chinese date, 5 parts of lily, 10 parts of lotus seed, 5 parts of longan aril, 10 parts of wild jujube seed, 5 parts of hawthorn, and 5 parts of kudzu root, and mix them evenly to obtain the traditional Chinese medicine composition.

[0055] Example 3 Traditional Chinese medicine composition

[0056] Take 20 parts of roasted licorice, 15 parts of malt, 15 parts of Chinese date, 15 parts of lily, 20 parts of lotus seed, 15 parts of longan aril, 20 parts of wild jujube seed, 20 parts of hawthorn, and 20 parts of kudzu root, and mix them evenly to obtain the traditional Chinese medicine composition.

[0057] Example 4 Traditional Chinese medicine composition

[0058] Take 15 parts of roasted licorice root, 10 parts of malt, 10 parts of Chinese date, 10 parts of lily, 15 parts of lotus seed, 10 parts of longan aril, 15 parts of wild jujube seed, 30 parts of gardenia fruit, 10 parts of raw oyster, 10 parts of peach kernel, 10 parts of hawthorn fruit, and 10 parts of kudzu root. After mixing evenly, the described traditional Chinese medicine composition is obtained.

[0059] Traditional Chinese Medicine Composition of Example 5

[0060] Take 10 parts of roasted licorice root, 5 parts of malt, 5 parts of Chinese date, 5 parts of lily, 10 parts of lotus seed, 5 parts of longan aril, 10 parts of wild jujube seed, 20 parts of gardenia fruit, 5 parts of raw oyster, 5 parts of peach kernel, 5 parts of hawthorn fruit, and 5 parts of kudzu root. After mixing evenly, the described traditional Chinese medicine composition is obtained.

[0061] Traditional Chinese Medicine Composition of Example 6

[0062] Take 20 parts of roasted licorice root, 15 parts of malt, 15 parts of Chinese date, 15 parts of lily, 20 parts of lotus seed, 15 parts of longan aril, 20 parts of wild jujube seed, 60 parts of gardenia fruit, 20 parts of raw oyster, 20 parts of peach kernel, 20 parts of hawthorn fruit, and 20 parts of kudzu root. After mixing evenly, the described traditional Chinese medicine composition is obtained.

[0063] Traditional Chinese Medicine Composition of Comparative Example 1

[0064] Take 15 parts of roasted licorice root, 10 parts of malt, 10 parts of Chinese date, 10 parts of lily, 15 parts of lotus seed, 10 parts of longan aril, 15 parts of wild jujube seed, 30 parts of gardenia fruit, 10 parts of hawthorn fruit, and 10 parts of kudzu root. After mixing evenly, the described traditional Chinese medicine composition is obtained.

[0065] Traditional Chinese Medicine Composition of Comparative Example 2

[0066] Take 15 parts of roasted licorice root, 10 parts of malt, 10 parts of Chinese date, 10 parts of lily, 15 parts of lotus seed, 10 parts of longan aril, 15 parts of wild jujube seed, 10 parts of raw oyster, 10 parts of hawthorn fruit, and 10 parts of kudzu root. After mixing evenly, the described traditional Chinese medicine composition is obtained.

[0067] Traditional Chinese Medicine Composition of Comparative Example 3

[0068] Take 15 parts of roasted licorice root, 10 parts of malt, 10 parts of Chinese date, 10 parts of lily, 15 parts of lotus seed, 10 parts of longan aril, 15 parts of wild jujube seed, 10 parts of peach kernel, 10 parts of hawthorn fruit, and 10 parts of kudzu root. After mixing evenly, the described traditional Chinese medicine composition is obtained.

[0069] Experimental Example 1

[0070] Wild-type AB strain zebrafish, 5 days after fertilization, were used for the evaluation test of the therapeutic effect of the traditional Chinese medicine composition of the present invention on insomnia. The zebrafish were raised in a zebrafish breeding system and fed with Artemia nauplii regularly in the morning and afternoon. The breeding water temperature was (28.5±0.5)°C, the conductivity was (500±50) μS / cm, the pH value was 7.5±0.5, and the photoperiod was 14 h of light and 10 h of darkness. One afternoon before collecting the embryos, healthy adult wild-type zebrafish were selected, paired at a male-female ratio of 1:1 and placed in a breeding tank, and the male and female zebrafish were separated by a partition. After the light was turned on the next morning, the partition was removed, and the embryos were collected after 1 h of free mating. After the embryos were collected, they were washed and selected, and then an appropriate amount of culture medium was added, and they were incubated in a biochemical incubator at (28.5±0.5)°C for later use.

[0071] A blank control group, a model group, a drug group, and a melatonin group were set up. 96 wild-type AB strain zebrafish 5 days after fertilization were selected and placed in a 24-well plate. One zebrafish was treated in each well (experimental group), and the volume of each well was 100 μL. Melatonin or the test drug was co-treated with caffeine, and after 24 h of light exposure, 8 zebrafish were selected from each group and transferred to a 96-well plate, 1 zebrafish per well. The statistical analysis results of the relative activity were used to evaluate the efficacy of the traditional Chinese medicine composition on caffeine- and light-induced insomnia in zebrafish.

[0072] Detection index: Detect the movement distance of zebrafish embryos to evaluate the efficacy of the formula of this patent on caffeine- and light-induced insomnia in zebrafish; the detection results are shown in Table 1.

[0073] The preparation methods of the drugs tested in Drug Groups 1-5 are as follows: The traditional Chinese medicine compositions described in Example 1, Example 4, and Comparative Examples 1-3 were respectively taken, and 10 times the total weight of the traditional Chinese medicine composition of water was added, and reflux extraction was carried out at 100°C for 1 h. After the extraction was completed, the extract was concentrated and dried to obtain an extract; the extracts obtained by extracting each traditional Chinese medicine composition were used as test drugs.

[0074] Table 1. Statistical results table of zebrafish embryo movement distance

[0075]

[0076] It can be seen from the experimental results in Table 1 that the movement distance of zebrafish embryos in the model group was much higher than that in the blank control group; this indicates that the model was successfully established.

[0077] It can be seen from the experimental results in Table 1 that the movement distance of zebrafish embryos in Drug Group 1 was significantly lower than that in the model

[0078] group; this shows that: the traditional Chinese medicine composition of the present invention containing Glycyrrhizae Radix Praeparata, Fructus Hordei Germinatus, Fructus Jujubae, Bulbus Lilii, Semen Nelumbinis, Arillus Longan, Semen Ziziphi Spinosae, Fructus Crataegi, and Radix Puerariae has a good effect on preventing and / or treating insomnia.

[0079] It can be seen from the experimental results in Table 1 that the moving distance of zebrafish embryos in Drug Group 2 is further significantly lower

[0080] than that in

[0081] Drug Group 1 and also lower than that in the melatonin group; this indicates that: further adding Gardenia jasminoides Ellis, Concha Ostreae, and Semen Persicae to the traditional Chinese medicine composition containing Glycyrrhizae Radix Preparata, Fructus Hordei Germinatus, Fructus Jujubae, Bulbus Lilii, Semen Nelumbinis, Arillus Longan, Semen Ziziphi Spinosae, Fructus Crataegi, and Radix Puerariae can further significantly enhance the preventive and / or therapeutic effects of the traditional Chinese medicine composition on insomnia; making the traditional Chinese medicine composition have very excellent preventive and / or therapeutic effects on insomnia.

[0082] It can be seen from the experimental results in Table 1 that, compared with Drug Group 1, although the moving distance of zebrafish embryos in Drug Groups 3 - 4 has decreased, the decrease amplitude is not large and is much smaller than that in Drug Group 2; this indicates that: it is necessary to further add Gardenia jasminoides Ellis, Concha Ostreae, and Semen Persicae simultaneously to the traditional Chinese medicine composition containing Glycyrrhizae Radix Preparata, Fructus Hordei Germinatus, Fructus Jujubae, Bulbus Lilii, Semen Nelumbinis, Arillus Longan, Semen Ziziphi Spinosae, Fructus Crataegi, and Radix Puerariae to further significantly enhance the preventive and / or therapeutic effects of the traditional Chinese medicine composition on insomnia; however, simply adding a single Gardenia jasminoides Ellis, Concha Ostreae, or Semen Persicae cannot further significantly enhance the preventive and / or therapeutic effects of the traditional Chinese medicine composition on insomnia. Further adding Gardenia jasminoides Ellis, Concha Ostreae, and Semen Persicae simultaneously to the traditional Chinese medicine composition containing Glycyrrhizae Radix Preparata, Fructus Hordei Germinatus, Fructus Jujubae, Bulbus Lilii, Semen Nelumbinis, Arillus Longan, Semen Ziziphi Spinosae, Fructus Crataegi, and Radix Puerariae can synergistically enhance the preventive and / or therapeutic effects of the composition on liver injury.

Claims

1. A Chinese medicine composition, characterized in that: It contains the following Chinese medicinal ingredients: roasted licorice, malt, jujube, lily, lotus seed, longan pulp, spinach seed, hawthorn and kudzu root.

2. The Chinese medicine composition according to claim 1, characterized in that: Contains the following Chinese medicine components in parts by weight: 5-40 parts of roasted licorice root, 5-30 parts of malt, 5-30 parts of jujube, 5-30 parts of lily, 10-30 parts of lotus seeds, 5-30 parts of longan pulp, 5-30 parts of sour jujube kernel, 5-20 parts of hawthorn, and 5-20 parts of kudzu root.

3. The Chinese medicine composition according to claim 1, characterized in that Contains the following Chinese medicine components in parts by weight: 15 parts of roasted liquorice root, 10 parts of malt, 10 parts of jujube, 10 parts of lily, 15 parts of lotus seeds, 10 parts of longan pulp, 15 parts of spiny jujube seeds, 10 parts of hawthorn, and 10 parts of kudzu root; Or 10 parts of roasted liquorice root, 5 parts of malt, 5 parts of jujube, 5 parts of lily, 10 parts of lotus seeds, 5 parts of longan pulp, 10 parts of spiny jujube seeds, 5 parts of hawthorn, and 5 parts of kudzu root; Or 20 parts of roasted liquorice, 15 parts of malt, 15 parts of jujube, 15 parts of lily, 20 parts of lotus seeds, 15 parts of longan pulp, 20 parts of spinach jujube seeds, 20 parts of hawthorn, and 20 parts of kudzu root.

4. The Chinese medicine composition according to claim 1, characterized in that: The traditional Chinese medicine composition also contains gardenia, raw oyster and peach kernel.

5. The Chinese medicine composition according to claim 4, characterized in that: Contains the following Chinese medicine components in parts by weight: 5-40 parts of roasted licorice root, 5-30 parts of malt, 5-30 parts of jujube, 5-30 parts of lily, 10-30 parts of lotus seeds, 5-30 parts of longan pulp, 5-30 parts of spinach kernel, 5-60 parts of gardenia, 5-20 parts of raw oyster, 5-20 parts of peach kernel, 5-20 parts of hawthorn, and 5-20 parts of kudzu root.

6. The Chinese medicine composition according to claim 5, characterized in that: Contains the following Chinese medicine components in parts by weight: 10-30 parts of roasted licorice root, 5-20 parts of malt, 5-20 parts of jujube, 5-20 parts of lily, 10-30 parts of lotus seeds, 5-20 parts of longan pulp, 10-30 parts of spiny jujube kernel, 10-40 parts of gardenia, 5-20 parts of raw oyster, 5-20 parts of peach kernel, 5-20 parts of hawthorn, and 5-20 parts of kudzu root.

7. The Chinese medicine composition according to claim 5, characterized in that: Contains the following Chinese medicine components in parts by weight: 15 parts of roasted liquorice root, 10 parts of malt, 10 parts of jujube, 10 parts of lily, 15 parts of lotus seed, 10 parts of longan pulp, 15 parts of spiny jujube kernel, 30 parts of gardenia, 10 parts of raw oyster, 10 parts of peach kernel, 10 parts of hawthorn, 10 parts of kudzu root; Or, 10 parts of roasted liquorice root, 5 parts of malt, 5 parts of jujube, 5 parts of lily, 10 parts of lotus seed, 5 parts of longan pulp, 10 parts of spiny jujube kernel, 20 parts of gardenia, 5 parts of raw oyster, 5 parts of peach kernel, 5 parts of hawthorn, 5 parts of kudzu root; Or, 20 parts of roasted liquorice, 15 parts of malt, 15 parts of jujube, 15 parts of lily, 20 parts of lotus seeds, 15 parts of longan pulp, 20 parts of spiny jujube seeds, 60 parts of gardenia, 20 parts of raw oysters, 20 parts of peach kernels, 20 parts of hawthorns, and 20 parts of kudzu roots.

8. Use of the traditional Chinese medicine composition according to any one of claims 1 to 7 in the preparation of a medicament for preventing and / or treating insomnia.

9. The use according to claim 8, characterized in that: The medicine uses the extract or extract obtained by using the above-mentioned Chinese medicine composition as raw material as the effective ingredient.

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