ECMO automatic blood gas analysis device and method

Abstract

The invention discloses an ECMO automatic blood gas analysis device. The ECMO automatic blood gas analysis device comprises an ECMO module, a sampling module and a blood gas analysis module, the ECMO module is composed of a vein tube, a centrifugal pump, an oxygenator and an artery tube which are sequentially connected in series, the liquid inlet end of the vein tube is connected with the vein of a patient, and the liquid outlet end of the artery tube is connected with the artery of the patient to form a blood circulation loop; the blood gas analysis module is communicated with the arterial duct through a sampling tube so as to obtain to-be-detected blood from the arterial duct; the blood gas analysis module is used for detecting blood gas analysis parameters of the to-be-detected blood sample and analyzing a detection result to judge whether the blood internal environment related data of the to-be-detected blood sample is abnormal or not; the sampling module is arranged on the sampling tube and is used for acquiring a blood sample to be detected from an arterial duct and conveying the blood sample to be detected to the blood gas analysis module; a blood sample is directly extracted from a blood circulation loop of ECMO, and automatic detection and analysis are performed through the blood gas analysis module, so that real-time monitoring of blood gas of an ECMO patient is realized.

Description

Technical Field

[0001] The present invention relates to the technical field related to ECMO, and particularly to an ECMO automatic blood gas analysis device and method. Background Art

[0002] ECMO (Extracorporeal Membrane Oxygenation) is an extracorporeal life support technology widely used in intensive care, usually for patients with severe respiratory failure or heart failure. When the cardiopulmonary function of a patient is severely impaired, ECMO can supply oxygen to the blood and remove carbon dioxide from the blood through an external machine, thereby replacing the functions of the heart and lungs and maintaining the vital signs of the patient.

[0003] Although ECMO plays a crucial role in the treatment of critically ill patients, its application depends on the accurate monitoring of the patient's blood parameters, especially blood gas analysis; blood gas analysis is an important indicator for monitoring the blood acid-base, oxygenation, and ventilation status of ECMO patients, and can help doctors evaluate the treatment effect of patients and adjust ECMO parameters.

[0004] However, during the current ECMO treatment process, blood gas analysis usually relies on manual operations, requiring doctors to regularly collect blood samples and send them to the laboratory for analysis, which is a cumbersome and time-consuming process; and there may be a time delay in this process, resulting in a lag in the assessment of the patient's condition and affecting timely treatment decisions.

[0005] Therefore, the real-time blood gas monitoring for ECMO patients has become a pain point in clinical applications; in order to improve the efficiency and accuracy of ECMO treatment, an automated, real-time, and accurate blood gas analysis technology is urgently needed. Summary of the Invention

[0006] The purpose of the present invention is to provide an ECMO automatic blood gas analysis device and method, which can perform real-time blood gas analysis on ECMO patients to solve the technical problems existing in the prior art.

[0007] To solve the above technical problems, the present invention specifically provides the following technical solutions:

[0008] An ECMO automatic blood gas analysis device, comprising an ECMO module, a sampling module and a blood gas analysis module; the ECMO module consists of a centrifugal pump and an oxygenator, wherein the inlet end of the centrifugal pump is connected to the vein of the patient through a venous tube, and the outlet end of the oxygenator is connected to the artery of the patient through an arterial tube to form a blood circulation loop; the blood gas analysis module is connected to the arterial tube through a sampling tube to obtain the blood to be tested from the arterial tube; the blood gas analysis module is used to detect the blood gas analysis parameters of the blood sample to be tested and analyze the detection results to determine whether the data related to the blood internal environment of the blood sample to be tested is abnormal; the sampling module is arranged on the sampling tube, and the sampling module is used to obtain the blood sample to be tested from the arterial tube and transport the blood sample to be tested to the blood gas analysis module.

[0009] Further, the sampling module includes a one-way valve and a sampling pump connected in series on the sampling tube.

[0010] Further, the sampling module further includes an anticoagulation component for injecting heparin into the sampling tube to prevent the blood sample to be tested from coagulating.

[0011] Further, the blood gas analysis parameters include one or more parameters of conventional sodium, chlorine, potassium, calcium, arterial oxygen partial pressure, arterial carbon dioxide partial pressure, lactic acid, PH, bicarbonate, hemoglobin and oxygen saturation.

[0012] Further, the blood gas analysis module is communicatively connected to a control module for sending the analysis result to the control module; the control module is communicatively connected to a plurality of intravenous infusion pumps. If the data related to the blood internal environment is abnormal, the control module controls the intravenous infusion pumps to pump the corresponding drugs into the vein of the patient to correct the disorder of the patient's blood internal environment.

[0013] Further, an oxygen flow meter is provided on the venous tube, and the oxygen flow meter is communicatively connected to the control module. The control module controls the oxygenator to adjust the oxygen concentration and oxygen flow according to the parameters related to oxygen supply and oxygen consumption fed back by the oxygen flow meter.

[0014] Further, the control module is communicatively connected to the sampling module and outputs a sampling instruction to the sampling module for controlling the time and blood volume of obtaining the blood sample to be tested.

[0015] Further, the control module is in two-way communication connection with the blood gas analysis module, so that the blood gas analysis module not only sends the analysis result to the control module, but also the control module outputs a detection and analysis instruction to the blood gas analysis module after the sampling module transports the blood sample to be tested to the blood gas analysis module.

[0016] To solve the above technical problems, the present invention further provides the following technical solutions:

[0017] An ECMO automatic blood gas analysis method, based on an ECMO module, the ECMO module is composed of a venous tube, a centrifugal pump, an oxygenator, and an arterial tube connected in series in sequence. Among them, the inlet end of the venous tube is connected to the vein of the patient, and the outlet end of the arterial tube is connected to the artery of the patient to form a blood circulation loop; it includes the following steps:

[0018] Step 001, the control module outputs a sampling instruction to the sampling module, and the sampling module starts to extract a blood sample from the arterial tube and transports the blood sample to the blood gas analysis module;

[0019] Step 002, the control module outputs a detection and analysis instruction to the blood gas analysis module, and the blood gas analysis module starts to detect the blood gas analysis parameters of the blood sample and analyze the detection results, and sends the analysis results to the control module;

[0020] Step 003, the control module receives the analysis results from the blood gas analysis module. If the blood gas analysis parameters are abnormal, the control module controls the venous infusion pump to pump or the medical staff manually pumps the corresponding drug into the vein of the patient to correct the disorder of the patient's blood internal environment;

[0021] At the same time, the control module also receives the blood oxygen supply and oxygen consumption of the blood about to enter the oxygenator fed back by the oxygen flow meter located on the venous tube, and controls the oxygenator to adjust the oxygen concentration and oxygen flow rate so that the blood oxygen supply and oxygen consumption of the blood entering the arterial tube from the oxygenator meet the requirements;

[0022] Step 004, the control module periodically outputs a sampling instruction to the sampling module to repeat the above steps.

[0023] The present invention has the following beneficial effects compared with the prior art:

[0024] The ECMO automatic blood gas analysis device provided by the present invention is integrated with a conventional ECMO device, directly extracts a blood sample from the blood circulation loop of the ECMO, and performs automatic detection and analysis through the blood gas analysis module to realize real-time monitoring of the blood gas of ECMO patients.

[0025] Furthermore, when the device detects abnormal data related to the blood internal environment of ECMO patients, it can pump relevant drugs to adjust the balance, greatly shortening the reaction time of medical staff.

[0026] The present invention also provides an ECMO automatic blood gas analysis method. Through a preset control program, the blood circulating outside the ECMO device is periodically sampled to detect the blood gas of the ECMO patient in real time, and data feedback is performed. When the detected data is abnormal, the doctor is prompted to take corresponding measures, or relevant corresponding measures are directly taken. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only exemplary, and for those of ordinary skill in the art, without creative efforts, other implementation drawings can be obtained based on the provided drawings.

[0028] Figure 1 Control flowchart for blood gas analysis of the ECMO automatic blood gas analysis device;

[0029] Figure 2 Control flowchart for self-energy feedback of the ECMO automatic blood gas analysis device;

[0030] Figure 3 Control flowchart for real-time detection of the ECMO automatic blood gas analysis device.

[0031] Among them, 1 - ECMO module, 2 - sampling module, 3 - blood gas analysis module, 4 - venous tube, 5 - arterial tube, 6 - control module;

[0032] 11 - centrifugal pump, 12 - oxygenator;

[0033] 21 - sampling tube, 22 - one-way valve, 23 - sampling pump;

[0034] 61 - venous infusion pump, 62 - oxygen flowmeter. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0035] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0036] As Figure 1 shown, the present invention provides an implementation of an ECMO automatic blood gas analysis device, including an ECMO module 1, a sampling module 2, and a blood gas analysis module 3.

[0037] In this embodiment, the ECMO module 1 can select a conventional ECMO system. Therefore, the structure of the ECMO module 1 is not limited.

[0038] For the convenience of explaining the ECMO automatic blood gas analysis device, in this embodiment, an example of the ECMO module 1 is given as shown in the figure:

[0039] The ECMO module 1 is composed of a centrifugal pump 11 and an oxygenator 12. Among them, the liquid inlet end of the centrifugal pump 11 is connected to the patient's vein through a venous tube 4, and the liquid outlet end of the oxygenator 12 is connected to the patient's artery through an arterial tube 5 to form a blood circulation loop.

[0040] The patient is intubated in the vein, and the venous blood is drawn out of the body through the centrifugal pump 11, oxygenated by the oxygenator 12 to become arterial blood, and the arterial blood is then transfused back into the patient's body through the arterial tube 5; the oxygenator 12 is used to temporarily replace the function of the lungs during extracorporeal circulation, perform gas exchange on the blood, discharge carbon dioxide and absorb oxygen.

[0041] During ECMO treatment, with the changes in oxygen supply and oxygen consumption of organ tissues, it affects the homeostasis of the patient's blood internal environment. It is necessary to evaluate the patient's oxygen supply and oxygen consumption, as well as the changes in the blood internal environment, including acid-base balance and electrolyte levels, which is crucial for the treatment of the patient.

[0042] The blood gas analysis module 3 is connected to the arterial tube 5 through a sampling tube 21 to obtain the blood to be tested from the arterial tube 5; the blood gas analysis module 3 is used to detect the blood gas analysis parameters of the blood sample to be tested and analyze the test results to determine whether the data related to the blood internal environment of the blood sample to be tested is abnormal.

[0043] In this embodiment, the blood gas analysis module 3 can be a blood gas analyzer or a biochemical analyzer, as long as it is a detection device that can detect the state of the blood internal environment and has the function of sending data information outward.

[0044] Furthermore, the blood gas analysis parameters include one or more of the parameters such as conventional sodium, chlorine, potassium, calcium, arterial oxygen partial pressure, arterial carbon dioxide partial pressure, lactate, PH, bicarbonate, hemoglobin, and oxygen saturation.

[0045] The sampling module 2 is arranged on the sampling tube 21. The sampling module 2 is used to obtain the blood sample to be tested from the arterial tube 5 and transport the blood sample to be tested to the blood gas analysis module 3.

[0046] In this embodiment, an example of the sampling module 2 is provided as shown in the figure;

[0047] The sampling module 2 includes a one-way valve 22 and a sampling pump 23 connected in series on the sampling tube 21. The sampling pump 23 is used to extract blood from the arterial tube 5 into the blood gas analysis module 3. The one-way valve 22 is used to ensure that the blood can only flow in one direction, prevent blood from flowing back, avoid the risk of infection, and at the same time, ensure the purity and accuracy of the detected blood sample.

[0048] Furthermore, the sampling module 2 further includes an anticoagulation component for injecting heparin into the sampling tube 21 to prevent the blood sample to be detected from coagulating and blocking the sampling tube 21 and the blood gas analysis module 3. Preferably, the position of the anticoagulation component on the sampling tube 21 is in the outlet direction of the one-way valve 22.

[0049] The ECMO automatic blood gas analysis device provided by this embodiment can obtain blood samples in real time and analyze them quickly, improving the efficiency of data collection and processing, reducing the interference of human factors, and thus improving the accuracy of diagnosis.

[0050] And it reduces the dependence on manual operations, reduces the time and energy required for manual sampling, processing, analysis, etc., thus saving a large amount of working time for medical staff and enabling them to focus more on other urgent medical tasks.

[0051] Furthermore, through more accurate and timely blood gas detection, doctors can identify the clinical changes of patients in the shortest time and quickly adjust the treatment strategy; this helps to improve the ECMO treatment effect and increase the survival rate of patients, especially in critically ill patients, which is particularly important.

[0052] In this embodiment, the ECMO automatic blood gas analysis device also has data storage and remote monitoring functions. It can be connected to the hospital internal system. Doctors can view the blood gas data of patients in real time through a dedicated device or the APP on the mobile terminal, perform trend analysis, and issue medical orders when necessary; this not only facilitates medical staff to make decisions, but also enables multi-disciplinary consultations or remote expert guidance, further improving the treatment effect.

[0053] At the same time, it can also record the long-term blood gas changes of patients, provide valuable historical data for subsequent diagnosis, treatment and follow-up, and provide support for medical staff for long-term management.

[0054] In this embodiment, the ECMO automatic blood gas analysis device includes a display screen for displaying the analysis results of the blood gas analysis module 3 in real time in front of the hospital bed to achieve rapid feedback. If the analysis results are abnormal, a warning sound will be emitted to prompt medical staff to take corresponding measures; for example, when blood acid-base imbalance is detected, it will prompt medical staff to operate the intravenous infusion pump 61 to manually pump the corresponding drug into the patient's vein, which can provide real-time support for clinical decisions.

[0055] Through real-time blood gas data feedback, the ECMO device can also dynamically adjust working parameters, such as oxygen flow rate, pump speed, etc.; for example, if the analysis result shows that the patient's PaO2 is too low, the system can automatically adjust the oxygen flow rate of the ECMO; making the treatment plan more personalized and precise, and being able to reduce the potential risks of the patient during the treatment process. Especially in critically ill patients who need close monitoring, the ability to adjust the plan in real time is crucial.

[0056] In this embodiment, to further improve the response efficiency of medical plan adjustment, the following embodiments are provided to achieve intelligent feedback on blood gas analysis results, such as Figure 2 shown:

[0057] The blood gas analysis module 3 is communicatively connected to the control module 6 for sending the analysis result to the control module 6; the control module 6 is communicatively connected to a plurality of intravenous infusion pumps 61. If the data related to the blood internal environment is abnormal, the control module 6 controls the corresponding intravenous infusion pump 61 to pump drugs into the patient's vein to correct the disorder of the patient's blood internal environment.

[0058] Furthermore, an oxygen flow meter 62 is provided on the venous tube 4. The oxygen flow meter 62 is communicatively connected to the control module 6. The control module 6 controls the oxygenator 12 to adjust the oxygen concentration and oxygen flow rate according to the parameters related to oxygen supply and oxygen consumption in the blood fed back by the oxygen flow meter 62, so that the oxygen saturation of the arterial blood formed after being processed by the oxygenator 12 meets the requirements.

[0059] In this embodiment, the ECMO automatic blood gas analysis device is mainly used for real-time detection of the blood gas of ECMO patients. However, real-time detection in the true sense is unrealistic and meaningless. Therefore, intermittent detection is adopted in this embodiment to feedback the detection results in real time to achieve real-time monitoring; to achieve the above purpose, the following embodiments are provided, such as Figure 3 shown:

[0060] The control module 6 is communicatively connected to the sampling module 2 and outputs a sampling instruction to the sampling module 2 after a certain time interval, mainly for controlling the time and blood volume for obtaining the blood sample to be detected.

[0061] The control module 6 is in bidirectional communication connection with the blood gas analysis module 3, so that the blood gas analysis module 3 not only sends the analysis result to the control module 6, but also the control module 6 outputs a detection and analysis instruction to the blood gas analysis module 3 after the sampling module 2 transports the blood sample to be detected to the blood gas analysis module 3.

[0062] The present invention further provides an implementation manner of an ECMO automatic blood gas analysis method. Based on the ECMO module 1, the ECMO module 1 is composed of a venous tube 4, a centrifugal pump 11, an oxygenator 12, and an arterial tube 5 connected in series in sequence. Among them, the liquid inlet end of the venous tube 4 is connected to the vein of the patient, and the liquid outlet end of the arterial tube 5 is connected to the artery of the patient, forming a blood circulation loop.

[0063] The ECMO automatic blood gas analysis method includes the following steps:

[0064] Step 001, the control module 6 outputs a sampling instruction to the sampling module 2. The sampling module starts to extract a blood sample from the arterial tube 5 and transports the blood sample to the blood gas analysis module 3.

[0065] Among them, the control module 6 uses a conventional PLC controller.

[0066] Step 002, the control module 6 outputs a detection and analysis instruction to the blood gas analysis module 3. The blood gas analysis module 3 starts to detect the blood gas analysis parameters of the blood sample and analyze the detection results, and sends the analysis results to the control module 6 to achieve real-time blood gas monitoring.

[0067] The blood gas analysis module 3 can be a blood gas analyzer or a biochemical analyzer, as long as it is a detection device that can detect the internal environment state of the blood and has the function of sending data information outward.

[0068] The blood gas analysis parameters include one or more of the parameters of conventional sodium, chlorine, potassium, calcium, arterial oxygen partial pressure, arterial carbon dioxide partial pressure, lactate, PH, bicarbonate, hemoglobin, and blood oxygen saturation.

[0069] Step 003, the control module 6 receives the analysis results from the blood gas analysis module 3. If the blood gas analysis parameters are abnormal, the control module 6 controls the corresponding venous infusion pump 61 to pump drugs into the vein of the patient or manually pumps the corresponding drugs into the vein of the patient by the medical staff to correct the disorder of the internal environment of the patient's blood.

[0070] Step 004, after a certain period of time, the control module 6 continues to output a sampling instruction to the sampling module 2 and repeats the above steps.

[0071] Step 005, while performing real-time blood gas monitoring, the oxygen flowmeter on the venous tube 4 feeds back the oxygen supply and oxygen consumption of the blood about to enter the oxygenator 12 to the control module 6 in real time. The control module 6 controls the oxygenator 12 to adjust the oxygen concentration and oxygen flow according to the relevant data so that the blood oxygen saturation of the blood entering the arterial tube 5 from the oxygenator 12 meets the requirements.

[0072] The above embodiments are only exemplary embodiments of the present application and are not intended to limit the present application. The protection scope of the present application is defined by the claims. Those skilled in the art can make various modifications or equivalent substitutions within the essence and protection scope of the present application, and such modifications or equivalent substitutions should also be regarded as falling within the protection scope of the present application.

Claims

1. An ECMO automatic blood gas analysis device, characterized in that: It comprises an ECMO module (1), a sampling module (2) and a blood gas analysis module (3); The ECMO module (1) is composed of a centrifugal pump (11) and an oxygenator (12), wherein the liquid inlet end of the centrifugal pump (11) is connected to the patient's vein through a venous tube (4), and the liquid outlet end of the oxygenator (12) is connected to the patient's artery through an arterial tube (5), thereby forming a blood circulation loop; The blood gas analysis module (3) is connected to the arterial tube (5) via a sampling tube (21) to obtain blood to be tested from the arterial tube (5); the blood gas analysis module (3) is used to test blood gas analysis parameters on the blood sample to be tested, and analyze the test results to determine whether the blood internal environment related data of the blood sample to be tested is abnormal; The sampling module (2) is arranged on the sampling tube (21), and the sampling module (2) is used to obtain the blood sample to be tested from the arterial tube (5), and transport the blood sample to be tested to the blood gas analysis module (3).

2. The ECMO automatic blood gas analyzer according to claim 1, characterized in that: The sampling module (2) comprises a one-way valve (22) and a sampling pump (23) which are connected in series on a sampling tube (21).

3. The ECMO automatic blood gas analyzer according to claim 1, characterized in that: The sampling module (2) also includes an anticoagulation component for injecting heparin into the sampling tube (21) to prevent the blood sample to be tested from clotting.

4. The ECMO automatic blood gas analyzer according to claim 1, characterized in that: The blood gas analysis parameters include one or more parameters of conventional sodium, chloride, potassium, calcium, arterial oxygen partial pressure, arterial carbon dioxide partial pressure, lactate, pH, bicarbonate, hemoglobin and blood oxygen saturation.

5. The ECMO automatic blood gas analyzer according to claim 1, characterized in that: The blood gas analysis module (3) is communicatively connected to a control module (6) for sending the analysis results to the control module (6); the control module (6) is communicatively connected to a plurality of intravenous infusion pumps (61); if the data related to the blood internal environment is abnormal, the control module (6) controls the corresponding intravenous infusion pumps (61) to pump drugs into the patient's veins to correct the disorder in the patient's blood internal environment.

6. The ECMO automatic blood gas analyzer according to claim 5, characterized in that: The venous tube (4) is provided with an oxygen flow meter (62), and the oxygen flow meter (62) is in communication connection with the control module (6). The control module (6) controls the oxygenator (12) to adjust the blood oxygen saturation of the blood in the arterial tube (5) according to the oxygen supply and oxygen consumption related parameters fed back by the oxygen flow meter (62).

7. The ECMO automatic blood gas analyzer according to claim 1, characterized in that: The control module (6) is in communication connection with the sampling module (2) and outputs a sampling instruction to the sampling module (2) for controlling the time and blood volume of obtaining the blood sample to be tested.

8. The ECMO automatic blood gas analyzer according to claim 1, characterized in that: The control module (6) is bidirectionally connected to the blood gas analysis module (3), so that the blood gas analysis module (3) not only sends the analysis results to the control module (6), but also outputs detection and analysis instructions to the blood gas analysis module (3) after the sampling module (2) delivers the blood sample to be detected to the blood gas analysis module (3).

9. An ECMO automatic blood gas analysis method, based on an ECMO module (1), wherein the ECMO module (1) is composed of a venous tube (4), a centrifugal pump (11), an oxygenator (12) and an arterial tube (5) connected in series, wherein: The liquid inlet end of the venous tube (4) is connected to the patient's vein, and the liquid outlet end of the arterial tube (5) is connected to the patient's artery, so as to form a blood circulation loop; It is characterized by comprising the following steps: Step 001, the control module (6) outputs a sampling instruction to the sampling module (2), and the sampling module starts to extract a blood sample from the arterial tube (5) and transmits the blood sample to the blood gas analysis module (3); Step 002, the control module (6) outputs a detection and analysis instruction to the blood gas analysis module (3), and the blood gas analysis module (3) starts to detect blood gas analysis parameters on the blood sample, analyzes the detection results, and sends the analysis results to the control module (6) to achieve real-time blood gas monitoring; Step 003, the control module (6) receives the analysis result from the blood gas analysis module (3), and if the blood gas analysis parameter is abnormal, the control module (6) controls the corresponding intravenous infusion pump (61) to pump the drug into the patient's vein or the medical staff manually pumps the corresponding drug into the patient's vein to correct the disorder in the patient's blood environment; Step 004, the control module (6) periodically outputs a sampling instruction to the sampling module (2) to repeat the above steps; Step 005, while carrying out real-time blood gas monitoring, the oxygen flowmeter on the venous tube (4) feeds back the blood oxygen supply and oxygen consumption of the blood about to enter the oxygenator (12) to the control module (6) in real time, and the control module (6) controls the oxygenator (12) to adjust the oxygen concentration and oxygen flow according to the relevant data, so that the blood oxygen saturation of the blood entering the arterial tube (5) from the oxygenator (12) meets the requirements.

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