Anti-wrinkle firming cosmetic composition containing hydroxypropyl tetrahydropyrantriol and preparation method of anti-wrinkle firming cosmetic composition

Abstract

The invention relates to the technical field of skin care, in particular to an anti-wrinkle firming cosmetic composition containing hydroxypropyl tetrahydropyrantriol and a preparation method thereof, and the anti-wrinkle firming cosmetic composition containing hydroxypropyl tetrahydropyrantriol comprises the following components: hydroxypropyl tetrahydropyrantriol subjected to specific modification treatment, acetyl hexapeptide-8, a plant extract, sodium hyaluronate, glycerol, xanthan gum, an emulsifying agent, a thickening agent and a preservative; and the balance of deionized water. After the hydroxypropyl tetrahydropyrantriol is subjected to nano-carrier loading modification treatment, the stability of the hydroxypropyl tetrahydropyrantriol is remarkably improved, and the hydroxypropyl tetrahydropyrantriol composition can play an important role in promoting the generation of protein polysaccharide in an extracellular matrix, increasing the skin compactness, stimulating aged cells, regulating cell behaviors, smoothing fine lines, fading pigmented spots and the like in the composition. By introducing acetyl hexapeptide-8, muscle contraction can be effectively reduced, then generation of wrinkles is reduced, and the acetyl hexapeptide-8 plays a key role in the anti-wrinkle aspect.

Description

Technical Field

[0001] The invention relates to the technical field of skin care, in particular to an anti-wrinkle and firming cosmetic composition containing hydroxypropyl tetrahydropyrantriol and a preparation method thereof. Background Art

[0002] With the development of society and the improvement of people's living standards, women pay more and more attention to skin care.

[0003] As the largest organ in the human body, the skin is not only a natural barrier for the body, but also an important external organ that shows personal health and charm. Especially for modern women, due to the influence of many factors such as dry environment and aging, the skin gradually develops a series of aging problems such as dryness, sagging, increased wrinkles, and dullness, which makes their demand for efficient and safe skin care products more urgent.

[0004] Hydroxypropyl tetrahydropyrantriol, also known as phosphenein, has attracted much attention in the field of skin care since it was developed by Lancome in 2006. It is a glycoprotein mixture made of xylose, which shows unique efficacy in skin care. After entering the skin, it can promote the production and construction of proteoglycans in the extracellular matrix. These proteoglycans are like gel-like protein networks, which can not only absorb a large amount of water, make the matrix gel-like, increase the firmness of cells and skin, but also serve as a channel for repair molecules to pass. At the same time, it can also re-stimulate aging cells, regulate the communication and dynamic behavior between cells, and then smooth fine lines, hide pores, and lighten pigment spots, comprehensively improving skin quality and achieving an effect similar to photorejuvenation.

[0005] However, in practical applications, hydroxypropyl tetrahydropyrantriol has some problems. When it is directly added to cosmetics, external factors such as temperature and illumination will have an impact on it, causing glycosidic bond cleavage, thereby greatly reducing the active effect. In addition, it is difficult to be evenly dispersed in conventional cosmetics, which not only affects the stability of the product, but also makes it impossible to give full play to its efficacy, limiting its widespread application in the field of cosmetics.

[0006] Therefore, it is of great practical significance to develop a cosmetic composition that can overcome these problems and give full play to the skin care effect of hydroxypropyl tetrahydropyrantriol. Summary of the invention

[0007] In view of the problems existing in the prior art, the present invention provides an anti-wrinkle and firming cosmetic composition containing hydroxypropyl tetrahydropyrantriol and a preparation method thereof.

[0008] To achieve the above object, the present invention provides the following technical solutions: An anti-wrinkle and firming cosmetic composition containing hydroxypropyl tetrahydropyrantriol, comprising the following components by weight percentage: 2%-3% of hydroxypropyltetrahydropyrantriol after specific modification treatment; 0.8%-1.2% of acetyl hexapeptide-8; 2%-3% of plant extract; 0.1%-0.3% of sodium hyaluronate; 8%-10% of glycerol; 0.2%-0.8% of xanthan gum; 1%-3% of emulsifier, and the emulsifier is a mixture of polysorbate 80 and glyceryl stearate in a mass ratio of (2-3):1; 0.5%-1% of thickener, and the thickener is carbomer; 0.1%-0.3% of preservative, and the preservative is phenoxyethanol; The balance is deionized water. As a further technical solution, the hydroxypropyltetrahydropyrantriol after specific modification treatment is obtained by loading hydroxypropyltetrahydropyrantriol with a nanocarrier; Among them, the nanocarrier is liposome. As a further technical solution, the specific steps of the preparation method of hydroxypropyltetrahydropyrantriol after specific modification treatment are as follows: Dissolve phospholipid and cholesterol in chloroform, an organic solvent, in a mass ratio of (3-5):1, and under the water bath condition of 40-50 °C, use a rotary evaporator to evaporate the solvent to form a film; Then add an aqueous solution containing hydroxypropyltetrahydropyrantriol for hydration, and the hydration temperature is controlled at 30-40 °C for 1-2 hours; Subsequently, perform ultrasonic treatment, the ultrasonic power is 200-300 W, and the ultrasonic time is 10-15 minutes. After rotary evaporation and drying, it is obtained; The mass fraction of the aqueous solution containing hydroxypropyltetrahydropyrantriol is 5-6%; The volume ratio of chloroform to the aqueous solution containing hydroxypropyltetrahydropyrantriol is 1:2. As a further technical solution, the plant extract includes asiaticoside, purslane extract and chamomile extract, among which asiaticoside accounts for 30%-50% of the total mass of the plant extract, purslane extract accounts for 30%-40%, and the balance is chamomile extract. As a further technical solution, the preparation method of asiaticoside is as follows: Wash and dry the centella asiatica raw material, crush it to 60-80 meshes, and adopt the supercritical carbon dioxide extraction method. The extraction pressure is 20-30 MPa, the extraction temperature is 40-50 °C, the entrainer is an ethanol aqueous solution with a volume fraction of 50%-60%, the extraction time is 2-3 hours, and after extraction, it is separated and purified by a macroporous adsorption resin column, and an ethanol aqueous solution with a volume fraction of 30%-40% is used as the eluent. Collect the eluent and concentrate it to obtain asiaticoside extract. As a further technical solution, the preparation method of the purslane extract is as follows: Wash the purslane raw materials, freeze-dry them, and then crush them to 80-100 mesh. Use the enzymatic hydrolysis method for extraction, add a mixed enzyme solution of cellulase and pectinase with a mass fraction of 0.8%-1%, with an enzymatic hydrolysis temperature of 45-55°C, a pH value of 4.5-5.5, and an enzymatic hydrolysis time of 1-2 hours. Then, perform ultrasonic-assisted extraction with an ultrasonic power of 150-200W and an ultrasonic time of 20-30 minutes. The extract is centrifuged and concentrated to obtain the purslane extract; Cellulase and pectinase are mixed in a mass ratio of 2:1. As a further technical solution, the preparation method of the chamomile extract is as follows: Wash the chamomile raw materials, dry them in the shade, and then crush them to 50-70 mesh. Use the subcritical water extraction method with an extraction temperature of 120-130°C, an extraction pressure of 3-5MPa, and an extraction time of 10-15 minutes. After extraction, it is concentrated under reduced pressure to obtain the chamomile extract. The method for an anti-wrinkle and firming cosmetic composition containing propyltetrahydropyrantriol includes the following steps: Add sodium hyaluronate, glycerol, and xanthan gum to an appropriate amount of water, and stir at 40-45°C for 30-40 minutes until completely dissolved to obtain an auxiliary material solution; Add the modified propyltetrahydropyrantriol and the mixed plant extract to the auxiliary material solution, and homogenize with a homogenizer at a rotation speed of 10000-12000r / min for 20-25 minutes; Add acetyl hexapeptide-8 to the homogenized product and stir evenly. As a further technical solution, during the process of adding sodium hyaluronate, glycerol, and xanthan gum to dissolve in an appropriate amount of water, an emulsifier and a thickener are added simultaneously, and during the stirring process, first stir at a rotation speed of 500-600r / min for 10-15 minutes to preliminarily disperse the emulsifier, and then increase the rotation speed to 1000-1200r / min to stir for the remaining time. As a further technical solution, after adding acetyl hexapeptide-8 and stirring evenly, perform vacuum degassing treatment on the obtained product, control the vacuum degree at -0.08MPa, and the degassing time is 10-15 minutes, and then perform aseptic filling.

[0009] Compared with the prior art, the beneficial effects of the present invention are as follows: After the propyltetrahydropyrantriol is modified by nano-carrier loading in the present invention, its stability is significantly improved, and it can play an important role in promoting the generation of proteoglycans in the extracellular matrix in the composition, increasing skin firmness, stimulating aging cells, regulating cell behavior, reducing fine lines, and fading pigment spots.

[0010] By introducing acetyl hexapeptide-8, muscle contraction can be effectively reduced, thereby reducing the generation of wrinkles and playing a key role in anti-wrinkle.

[0011] The present invention introduces a special plant extract. Through the combination of asiaticoside, purslane extract and chamomile extract, it can synergistically exert the effects of anti - inflammation, soothing and repairing the skin. Among them, asiaticoside helps to promote the synthesis of skin collagen, enhancing the elasticity and toughness of the skin; purslane extract can reduce skin inflammatory reactions and relieve skin allergy symptoms; chamomile extract has the effect of calming the skin and improving skin sensitivity.

[0012] The introduction of sodium hyaluronate can absorb and retain a large amount of water, increasing the water content of the skin and keeping the skin in a moist state.

[0013] In the cosmetic composition of the present invention, each component cooperates with each other to form a synergistic system. Propylhydroxytetrahydropyrantriol and acetyl hexapeptide - 8 play anti - wrinkle roles from different perspectives. The former reduces wrinkles by promoting the generation of extracellular matrix and regulating cell behavior, and the latter reduces wrinkles by reducing muscle contraction. The two work together to enhance the anti - wrinkle effect. Multiple components in the plant extract synergistically anti - inflame, soothe and repair the skin, and together with the anti - wrinkle components, improve the overall skin condition. Sodium hyaluronate and glycerol jointly moisturize, providing sufficient water for the skin and keeping the skin moist, which is beneficial for other active ingredients to play their roles better. Xanthan gum, emulsifier and thickener cooperate with each other to ensure the stability and texture uniformity of the product, enabling each component to exist stably in the product and being convenient for use.

[0014] Liposomes are used as nanocarriers to load propylhydroxytetrahydropyrantriol. Liposomes are bilayer membrane structures composed of phospholipids and cholesterol, etc., and propylhydroxytetrahydropyrantriol is encapsulated therein. This structure can provide a physical barrier for propylhydroxytetrahydropyrantriol, reducing its direct contact with factors such as temperature and light in the external environment, thereby reducing the risk of glycosidic bond cleavage and improving its stability. At the same time, the bilayer structure of liposomes is similar to the skin cell membrane, which helps to improve the skin permeability of propylhydroxytetrahydropyrantriol, making it easier to enter skin cells to play its role. Description of the Drawings

[0015] Figure 1 It is a graph showing the change in skin elasticity. Detailed Embodiments

[0016] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts belong to the scope of protection of the present invention.

[0017] The propyltetrahydropyranyl glucoside used in the present invention is obtained by being loaded and processed by a nanocarrier, and the nanocarrier is a liposome. This treatment can improve the stability and skin permeability of propyltetrahydropyranyl glucoside, enabling it to better exert its anti-wrinkle and firming effects. Acetyl hexapeptide-8 can reduce muscle contraction, thereby reducing the generation of wrinkles. The asiaticoside, purslane extract, and chamomile extract in the plant extract act synergistically to have the effects of anti-inflammation, soothing, and repairing the skin. Sodium hyaluronate can increase the water content of the skin, making the skin more moisturized. Glycerin is a commonly used moisturizer, xanthan gum can be used as a thickening and stabilizing agent, the emulsifier can make the oil-water system more stable, the thickening agent can adjust the viscosity of the product, and the preservative can ensure the quality and safety of the product during use.

[0018] Raw material preparation Preparation of propyltetrahydropyranyl glucoside with specific modification treatment Dissolve phospholipid and cholesterol in chloroform, an organic solvent, according to a mass ratio of (3 - 5):1. Under a water bath environment of 40 - 50 °C, use a rotary evaporator to evaporate the solvent to form a uniform thin film. This thin film provides a good basis for the subsequent hydration process. Then, add an aqueous solution containing propyltetrahydropyranyl glucoside with a mass fraction of 5 - 6% for hydration, control the hydration temperature at 30 - 40 °C, and the time at 1 - 2 hours. The hydration process enables the aqueous solution containing propyltetrahydropyranyl glucoside to fully contact with the phospholipid-cholesterol thin film to form a liposome structure. Subsequently, perform ultrasonic treatment with an ultrasonic power of 200 - 300 W and an ultrasonic time of 10 - 15 minutes to make the liposome more uniform and stable. Finally, obtain the propyltetrahydropyranyl glucoside with specific modification treatment through rotary evaporation and drying. Among them, the volume ratio of chloroform to the aqueous solution containing propyltetrahydropyranyl glucoside is 1:2.

[0019] Plant extract preparation Preparation of asiaticoside: Wash and dry the centella asiatica raw materials, and then crush them to 60 - 80 meshes. Use the supercritical carbon dioxide extraction method. Under the conditions of an extraction pressure of 20 - 30 MPa and an extraction temperature of 40 - 50 °C, use an ethanol aqueous solution with a volume fraction of 50 - 60% as an entrainer and extract for 2 - 3 hours. The supercritical carbon dioxide extraction method has the advantages of high selectivity, high extraction efficiency, and no organic solvent residues. After extraction, separate and purify through a macroporous adsorption resin column, use an ethanol aqueous solution with a volume fraction of 30 - 40% as an eluent, collect the eluent and concentrate it to obtain the asiaticoside extract.

[0020] Preparation of purslane extract: Wash the purslane raw materials, freeze-dry them, and then crush them to 80-100 mesh. Use the enzymatic hydrolysis method for extraction, add a mixed enzyme solution of cellulase and pectinase with a mass fraction of 0.8-1% (cellulase and pectinase are mixed in a mass ratio of 2:1), the enzymatic hydrolysis temperature is 45-55 °C, the pH value is 4.5-5.5, and enzymatically hydrolyze for 1-2 hours. The enzymatic hydrolysis method can specifically decompose the plant cell wall and improve the extraction rate of active ingredients. Then perform ultrasonic-assisted extraction, the ultrasonic power is 150-200W, the ultrasonic time is 20-30 minutes, and the extract is centrifuged, separated, and concentrated to obtain the purslane extract.

[0021] Preparation of chamomile extract: Wash the chamomile raw materials, dry them in the shade, and then crush them to 50-70 mesh. Use the subcritical water extraction method, under the conditions of an extraction temperature of 120-130 °C and an extraction pressure of 3-5 MPa, extract for 10-15 minutes. The subcritical water extraction method utilizes the special properties of water under specific conditions and can efficiently extract the active ingredients in plants. After extraction, it is concentrated under reduced pressure to obtain the chamomile extract.

[0022] Preparation of cosmetic composition The present invention provides an anti-wrinkle and firming cosmetic composition containing hydroxypropyltetrahydropyrantriol and its preparation method. The specific steps are as follows: Preparation of auxiliary material solution: Add sodium hyaluronate, glycerol, and xanthan gum to an appropriate amount of water, and at the same time add an emulsifier (a mixture of polysorbate 80 and glyceryl stearate in a mass ratio of (2-3):1) and a thickener (carbomer). First, stir at a speed of 500-600 r / min for 10-15 minutes to preliminarily disperse the emulsifier, and then increase the speed to 1000-1200 r / min and stir at 40-45 °C for 30-40 minutes until completely dissolved to obtain the auxiliary material solution.

[0023] Homogenization treatment: Add the modified hydroxypropyltetrahydropyrantriol and the mixed plant extract (madecassoside, purslane extract, and chamomile extract, where madecassoside accounts for 30%-50% of the total mass of the plant extract, purslane extract accounts for 30%-40%, and the balance is chamomile extract) to the auxiliary material solution, and homogenize with a homogenizer at a speed of 10000-12000 r / min for 20-25 minutes to make each component fully mixed and uniform.

[0024] Add acetyl hexapeptide-8: Add acetyl hexapeptide-8 (0.8%-1.2%) to the homogenized product and stir evenly.

[0025] Vacuum degassing and filling: Perform vacuum degassing treatment on the obtained product, control the vacuum degree at -0.08 MPa, and the degassing time is 10-15 minutes to remove the bubbles in the product and improve the stability of the product. Then perform aseptic filling to ensure the quality and safety of the product.

[0026] The following are specific examples Example 1 The embodiment of the present invention provides a preparation method of an anti-wrinkle and firming cosmetic composition containing propyltetrahydropyrantriol, and the steps are as follows: Raw material preparation Preparation of specifically modified propyltetrahydropyrantriol: Dissolve phospholipid and cholesterol in chloroform at a mass ratio of 3:1. Under the condition of a water bath at 40 °C, use a rotary evaporator to evaporate the solvent to form a film. Add an aqueous solution containing 5% propyltetrahydropyrantriol for hydration, with a hydration temperature of 30 °C and a time of 1 hour. Subsequently, perform ultrasonic treatment with a power of 200 W and a time of 10 minutes, and after rotary evaporation and drying, obtain specifically modified propyltetrahydropyrantriol.

[0027] Preparation of plant extracts Preparation of asiaticoside: Wash and dry the centella asiatica raw material, crush it to 60 mesh, and use the supercritical carbon dioxide extraction method with an extraction pressure of 20 MPa, an extraction temperature of 40 °C, an entrainer of an ethanol aqueous solution with a volume fraction of 50%, and an extraction time of 2 hours. After extraction, separate and purify it through a macroporous adsorption resin column, use an ethanol aqueous solution with a volume fraction of 30% as the eluent, collect the eluate and concentrate it to obtain asiaticoside extract.

[0028] Preparation of portulaca oleracea extract: Wash and freeze-dry the portulaca oleracea raw material, crush it to 80 mesh, and use the enzymatic hydrolysis method for extraction. Add a mixed enzyme solution of 0.8% cellulase and pectinase (cellulase and pectinase are mixed in a mass ratio of 2:1), with an enzymatic hydrolysis temperature of 45 °C, a pH value of 4.5, and an enzymatic hydrolysis time of 1 hour. Then perform ultrasonic-assisted extraction with a power of 150 W and a time of 20 minutes, and the extract is centrifuged, separated, and concentrated to obtain portulaca oleracea extract.

[0029] Preparation of chamomile extract: Wash and air-dry the chamomile raw material, crush it to 50 mesh, and use the subcritical water extraction method with an extraction temperature of 120 °C, an extraction pressure of 3 MPa, and an extraction time of 10 minutes. After extraction, concentrate it under reduced pressure to obtain chamomile extract.

[0030] Preparation of cosmetic composition Preparation of auxiliary solution: Add 0.1% sodium hyaluronate, 8% glycerol, 0.2% xanthan gum to an appropriate amount of water, and at the same time add 1% emulsifier (polysorbate 80 and glyceryl stearate are mixed in a mass ratio of 2:1) and 0.5% thickener (carbomer). First, stir at a speed of 500 r / min for 10 minutes to preliminarily disperse the emulsifier, then increase the speed to 1000 r / min and stir at 40 °C for 30 minutes until completely dissolved to obtain the auxiliary solution.

[0031] Homogenization treatment: Add 2% of specifically modified propyltetrahydropyrantriol and a mixed plant extract (made up of 30% asiaticoside by mass of the total plant extract, 30% purslane extract, and 40% chamomile extract) to the auxiliary material solution, and homogenize for 20 minutes at a rotational speed of 10,000 r / min using a homogenizer.

[0032] Add acetyl hexapeptide-8: Add 0.8% of acetyl hexapeptide-8 to the homogenized product and stir evenly.

[0033] Vacuum degassing and filling: Subject the obtained product to vacuum degassing treatment, control the vacuum degree at -0.08 MPa, and the degassing time is 10 minutes, then carry out aseptic filling.

[0034] Example 2 The embodiment of the present invention provides a preparation method of an anti-wrinkle and firming cosmetic composition containing propyltetrahydropyrantriol, and the steps are as follows: Raw material preparation Preparation of specifically modified propyltetrahydropyrantriol: Dissolve phospholipids and cholesterol in chloroform at a mass ratio of 4:1, and under the water bath condition of 45 °C, use a rotary evaporator to evaporate the solvent to form a film. Add an aqueous solution containing 5.5% of propyltetrahydropyrantriol for hydration, the hydration temperature is 35 °C, and the time is 1.5 hours. Subsequently, carry out ultrasonic treatment, the ultrasonic power is 250 W, and the ultrasonic time is 12 minutes. After rotary evaporation and drying, obtain specifically modified propyltetrahydropyrantriol.

[0035] Preparation of plant extract Preparation of asiaticoside: Wash and dry the centella asiatica raw material, crush it to 70 meshes, and adopt the supercritical carbon dioxide extraction method. The extraction pressure is 25 MPa, the extraction temperature is 45 °C, the entrainer is an ethanol aqueous solution with a volume fraction of 55%, and the extraction time is 2.5 hours. After extraction, separate and purify through a macroporous adsorption resin column, use an ethanol aqueous solution with a volume fraction of 35% as the eluent, collect the eluent and concentrate to obtain asiaticoside extract.

[0036] Preparation of purslane extract: Wash and freeze-dry the purslane raw material, crush it to 90 meshes, and adopt the enzymatic hydrolysis method for extraction. Add a mixed enzyme solution of 0.9% by mass of cellulase and pectinase (cellulase and pectinase are mixed at a mass ratio of 2:1), the enzymatic hydrolysis temperature is 50 °C, the pH value is 5, and the enzymatic hydrolysis time is 1.5 hours. Then carry out ultrasonic-assisted extraction, the ultrasonic power is 175 W, and the ultrasonic time is 25 minutes. The extract is centrifuged and concentrated to obtain purslane extract.

[0037] Preparation of chamomile extract: After washing and air-drying chamomile raw materials, they are crushed to 60 mesh. Using the subcritical water extraction method, the extraction temperature is 125 °C, the extraction pressure is 4 MPa, and the extraction time is 12 minutes. After extraction, chamomile extract is obtained by vacuum concentration.

[0038] Preparation of cosmetic composition Preparation of auxiliary material solution: 0.2% sodium hyaluronate, 9% glycerol, and 0.5% xanthan gum are added to an appropriate amount of water. At the same time, 2% emulsifier (polysorbate 80 and glyceryl stearate are mixed at a mass ratio of 2.5:1) and 0.7% thickener (carbomer) are added. First, stir at a speed of 550 r / min for 12 minutes to preliminarily disperse the emulsifier, and then increase the speed to 1100 r / min and stir at 42 °C for 35 minutes until completely dissolved to obtain the auxiliary material solution.

[0039] Homogenization treatment: 2.5% of specifically modified propyltetrahydropyrantriol and a mixed plant extract (madecassoside accounts for 40% of the total mass of the plant extract, purslane extract accounts for 35%, and chamomile extract accounts for 25%) are added to the auxiliary material solution, and homogenized with a homogenizer at a speed of 11000 r / min for 22 minutes.

[0040] Add acetyl hexapeptide-8: Add 1% acetyl hexapeptide-8 to the homogenized product and stir evenly.

[0041] Vacuum degassing and filling: The obtained product is subjected to vacuum degassing treatment, the vacuum degree is controlled at -0.08 MPa, and the degassing time is 12 minutes, and then aseptic filling is carried out.

[0042] Example 3 The embodiment of the present invention provides a preparation method of an anti-wrinkle and firming cosmetic composition containing propyltetrahydropyrantriol, and the steps are as follows: Raw material preparation Preparation of specifically modified propyltetrahydropyrantriol: Phospholipid and cholesterol are dissolved in chloroform at a mass ratio of 5:1. Under the water bath condition of 50 °C, a rotary evaporator is used to evaporate the solvent to form a film. An aqueous solution containing 6% propyltetrahydropyrantriol is added for hydration, the hydration temperature is 40 °C, and the time is 2 hours. Subsequently, ultrasonic treatment is carried out, the ultrasonic power is 300 W, and the ultrasonic time is 15 minutes. After rotary evaporation and drying, specifically modified propyltetrahydropyrantriol is obtained.

[0043] Plant extract preparation Preparation of asiaticoside: Wash and dry the centella asiatica raw materials, then crush them to 80 mesh. Use the supercritical carbon dioxide extraction method with an extraction pressure of 30 MPa, an extraction temperature of 50 °C, an entrainer of an ethanol aqueous solution with a volume fraction of 60%, and an extraction time of 3 hours. After extraction, separate and purify through a macroporous adsorption resin column, use an ethanol aqueous solution with a volume fraction of 40% as the eluent, collect the eluent and concentrate to obtain the asiaticoside extract.

[0044] Preparation of portulaca oleracea extract: Wash and freeze-dry the portulaca oleracea raw materials, then crush them to 100 mesh. Use the enzymatic hydrolysis method for extraction, add a mixed enzyme solution of 1% (by mass) cellulase and pectinase (cellulase and pectinase are mixed in a mass ratio of 2:1), with an enzymatic hydrolysis temperature of 55 °C, a pH value of 5.5, and an enzymatic hydrolysis time of 2 hours. Then perform ultrasonic-assisted extraction with an ultrasonic power of 200 W and an ultrasonic time of 30 minutes. The extract is separated by centrifugation and concentrated to obtain the portulaca oleracea extract.

[0045] Preparation of chamomile extract: Wash and air-dry the chamomile raw materials, then crush them to 70 mesh. Use the subcritical water extraction method with an extraction temperature of 130 °C, an extraction pressure of 5 MPa, an extraction time of 15 minutes, and after extraction, concentrate under reduced pressure to obtain the chamomile extract.

[0046] Preparation of cosmetic composition Preparation of auxiliary material solution: Add 0.3% sodium hyaluronate, 10% glycerol, 0.8% xanthan gum to an appropriate amount of water, and at the same time add 3% emulsifier (polysorbate 80 and glyceryl stearate are mixed in a mass ratio of 3:1) and 1% thickener (carbomer). First, stir at a speed of 600 r / min for 15 minutes to preliminarily disperse the emulsifier, then increase the speed to 1200 r / min and stir at 45 °C for 40 minutes until completely dissolved to obtain the auxiliary material solution.

[0047] Homogenization treatment: Add 3% of specifically modified propyltetrahydropyrantriol and a mixed plant extract (asiaticoside accounts for 50% of the total mass of the plant extract, portulaca oleracea extract accounts for 40%, and chamomile extract accounts for 10%) to the auxiliary material solution, and homogenize with a homogenizer at a speed of 12000 r / min for 25 minutes.

[0048] Add acetyl hexapeptide-8: Add 1.2% acetyl hexapeptide-8 to the homogenized product and stir evenly.

[0049] Vacuum degassing and filling: Perform vacuum degassing treatment on the obtained product, control the vacuum degree at -0.08 MPa, and the degassing time is 15 minutes, and then perform aseptic filling.

[0050] Control example Comparative Example 1: It is different from Example 1 in that the specifically modified propyltetrahydropyrantriol is not added, and the rest of the technical solutions remain unchanged.

[0051] Comparative Example 2: It is different from Example 1 in that the plant extract is not added, and the rest of the technical solutions remain unchanged.

[0052] Comparative Example 3: It is different from Example 1 in that acetyl hexapeptide-8 is not added, and the rest of the technical solutions remain unchanged.

[0053] Experiment: Anti-wrinkle effect test experiment Female volunteers were randomly selected, aged between 30 and 50 years old, and with obvious wrinkles on the face. The volunteers were randomly divided into 6 groups, with 4 people in each group, and they used the cosmetic compositions of Examples 1-3 and Comparative Examples 1-3 respectively, once in the morning and once in the evening every day for 8 consecutive weeks, and the daily dosage difference did not exceed 0.1 g. Before use, after 4 weeks of use, and after 8 weeks of use, a skin tester was used to measure the depth and area of the facial wrinkles of the volunteers.

[0054] The results are shown in the following table: Table 1

[0055] From the data in Table 1, it can be seen that for the cosmetic compositions of Examples 1-3, after 4 weeks and 8 weeks of use, both the wrinkle depth and area were significantly reduced, indicating that adding specifically modified propyltetrahydropyrantriol, plant extract, and acetyl hexapeptide-8 can effectively improve the anti-wrinkle effect of the cosmetics.

[0056] Skin moisturizing effect test experiment Female volunteers were randomly selected, aged between 20 and 40 years old, with healthy skin. The volunteers were randomly divided into 6 groups, with 4 people in each group, and they used the cosmetic compositions of Examples 1-3 and Comparative Examples 1-3 respectively, once in the morning and once in the evening every day for 4 consecutive weeks, and the daily dosage difference did not exceed 0.1 g. Before use, after 2 weeks of use, and after 4 weeks of use, a skin moisture tester was used to measure the moisture content of the volunteers' skin. The results are shown in the following table: Table 2

[0057] From the data in Table 2, it can be seen that for the cosmetic compositions of Examples 1-3, after 2 weeks and 4 weeks of use, the skin moisture content was significantly increased, indicating that long-term use of the products of the examples can effectively improve the skin moisturizing effect.

[0058] For further testing, the skin elasticity of the volunteers in Example 1 and Comparative Example 1 during the skin moisturizing effect test experiment was tracked weekly. The skin elasticity was detected by a skin elasticity tester. As Figure 1 shown, it can be seen that the skin elasticity after using the product of Example 1 has been significantly improved.

[0059] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific embodiments described. Obviously, many modifications and variations can be made according to the content of this specification.

Claims

1. An anti-wrinkle and firming cosmetic composition containing hydroxypropyltetrahydropyrantriol, characterized in that, By weight percentage, it contains the following components: Hydroxypropyltetrahydropyrantriol subjected to specific modification treatment: 2% - 3%; Acetyl hexapeptide - 8: 0.8% - 1.2%; Plant extract: 2% - 3%; Sodium hyaluronate: 0.1% - 0.3%; Glycerol: 8% - 10%; Xanthan gum: 0.2% - 0.8%; Emulsifier: 1% - 3%, and the emulsifier is a mixture of polysorbate 80 and glyceryl stearate in a mass ratio of (2 - 3):1; Thickener: 0.5% - 1%, and the thickener is carbomer; Preservative: 0.1% - 0.3%, and the preservative is phenoxyethanol; The balance is deionized water.

2. The anti-wrinkle and firming cosmetic composition containing hydroxypropyltetrahydropyrantriol according to claim 1, characterized in that, The hydroxypropyltetrahydropyrantriol subjected to specific modification treatment is obtained by loading hydroxypropyltetrahydropyrantriol with a nanocarrier; Among them, the nanocarrier is liposome.

3. The anti-wrinkle and firming cosmetic composition containing hydroxypropyltetrahydropyrantriol according to claim 2, characterized in that, The specific steps of the preparation method of hydroxypropyltetrahydropyrantriol subjected to specific modification treatment are as follows: Dissolve phospholipid and cholesterol in chloroform, an organic solvent, in a mass ratio of (3 - 5):1, and under the water bath condition of 40 - 50 °C, use a rotary evaporator to evaporate the solvent to form a film; then add an aqueous solution containing hydroxypropyltetrahydropyrantriol for hydration, control the hydration temperature at 30 - 40 °C, and the time is 1 - 2 hours; subsequently, perform ultrasonic treatment, the ultrasonic power is 200 - 300 W, the ultrasonic time is 10 - 15 minutes, and after rotary evaporation and drying, it is obtained; The mass fraction of the aqueous solution containing hydroxypropyltetrahydropyrantriol is 5 - 6%; The volume ratio of chloroform to the aqueous solution containing hydroxypropyltetrahydropyrantriol is 1:

2.

4. The anti-wrinkle and firming cosmetic composition containing hydroxypropyltetrahydropyrantriol according to claim 1, characterized in that, The plant extract includes asiaticoside, purslane extract, and chamomile extract, among which asiaticoside accounts for 30% - 50% of the total mass of the plant extract, purslane extract accounts for 30% - 40%, and the balance is chamomile extract.

5. The anti-wrinkle and firming cosmetic composition containing hydroxypropyltetrahydropyrantriol according to claim 4, characterized in that, The preparation method of asiaticoside is as follows: Wash and dry the centella asiatica raw material, crush it to 60 - 80 mesh, adopt the supercritical carbon dioxide extraction method, the extraction pressure is 20 - 30 MPa, the extraction temperature is 40 - 50 °C, the entrainer is an ethanol aqueous solution with a volume fraction of 50% - 60%, the extraction time is 2 - 3 hours, and after extraction, it is separated and purified by a macroporous adsorption resin column, using an ethanol aqueous solution with a volume fraction of 30% - 40% as the eluent, collect the eluent and concentrate to obtain the asiaticoside extract.

6. The anti-wrinkle and firming cosmetic composition containing hydroxypropyltetrahydropyrantriol according to claim 4, characterized in that, The preparation method of purslane extract is as follows: Wash and freeze - dry the purslane raw material, crush it to 80 - 100 mesh, adopt enzymatic hydrolysis extraction, add a mixed enzyme solution of cellulase and pectinase with a mass fraction of 0.8% - 1%, the enzymatic hydrolysis temperature is 45 - 55 °C, the pH value is 4.5 - 5.5, the enzymatic hydrolysis time is 1 - 2 hours, then perform ultrasonic - assisted extraction, the ultrasonic power is 150 - 200 W, the ultrasonic time is 20 - 30 minutes, and the extract is centrifuged, separated, and concentrated to obtain the purslane extract; Cellulase and pectinase are mixed in a mass ratio of 2:

1.

7. The anti-wrinkle and firming cosmetic composition containing hydroxypentyltetrahydropyrantriol according to claim 4, characterized in that The preparation method of the chamomile extract is as follows: Wash and air-dry the chamomile raw materials, then crush them to 50-70 mesh. Use the subcritical water extraction method, with an extraction temperature of 120-130 °C, an extraction pressure of 3-5 MPa, and an extraction time of 10-15 minutes. After extraction, obtain the chamomile extract by vacuum concentration.

8. A method for preparing an anti-wrinkle and firming cosmetic composition containing propyltetrahydropyrantriol according to any one of claims 1-7, characterized in that, It includes the following steps: Add sodium hyaluronate, glycerol, and xanthan gum into an appropriate amount of water, and stir at 40-45 °C for 30-40 minutes until completely dissolved to obtain an auxiliary material solution. Add the modified hydroxypropyltetrahydropyrantriol and the mixed plant extract into the auxiliary material solution, and homogenize with a homogenizer at a rotation speed of 10000-12000 r / min for 20-25 minutes. Add acetyl hexapeptide-8 to the homogenized product and stir evenly.

9. The preparation method according to claim 8, wherein During the process of adding sodium hyaluronate, glycerol, and xanthan gum to dissolve in an appropriate amount of water, add an emulsifier and a thickener at the same time. During the stirring process, first stir at a rotation speed of 500-600 r / min for 10-15 minutes to preliminarily disperse the emulsifier, and then increase the rotation speed to 1000-1200 r / min to stir for the remaining time.

10. The preparation method according to claim 8, characterized in that, After adding acetyl hexapeptide-8 and stirring evenly, perform vacuum degassing treatment on the obtained product, control the vacuum degree at -0.08 MPa, and the degassing time is 10-15 minutes. Then perform aseptic filling.

Images