Antibacterial skin protection composition as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of skin care products, and particularly relates to an antibacterial skin protection composition as well as a preparation method and application thereof. The antibacterial skin protection composition provided by the invention is prepared from the following components in parts by mass: 10 to 25 parts of durian shell extraction essence, 3 to 12 parts of coconut oil, 2 to 5 parts of sorbitol, 3 to 8 parts of glycerol, 3 to 7 parts of polyvinyl alcohol, 2 to 3 parts of decamethylcyclopentanosiloxane, 6 to 12 parts of 1, 2-propylene glycol, 4 to 10 parts of hexadecanol and 3 to 9 parts of glyceryl monostearate. The durian shell extraction essence is obtained by sequentially carrying out heating reflux, cold-pressing extraction, water leaching and subcritical water extraction on durian shells. The antibacterial skin protection composition provided by the invention has good sterilizing and moisturizing effects, is mild and non-irritant, can emit natural and fresh fragrance, and meets the requirements of modern consumers on healthy skin care products.

Description

Technical Field

[0001] The present invention belongs to the technical field of skin care products, and particularly relates to an antibacterial skin protection composition, a preparation method thereof and an application thereof. Background Art

[0002] A large number of microbial communities are enriched on human skin, and these microorganisms include various microorganisms such as bacteria, fungi, viruses and parasites. These microbial populations are collectively referred to as skin flora. Under specific circumstances, such as when the human body's resistance declines or the skin is injured, some microorganisms in the skin flora may cause diseases. Moreover, the destructive effect of bacteria will lead to various bad conditions on the skin, such as damage to the skin barrier, making it vulnerable to external environmental physical factors such as wind chill, cold and heat, and biological factors such as microorganisms, and the water and electrolytes in the skin are also prone to evaporation or loss. Therefore, effective antibacterial while skin care is also the most important basic means of skin care and beauty.

[0003] Currently, in existing skin care cosmetics, the antibacterial components are usually chemically synthesized substances, such as antibiotics, which are irritating to the skin after long-term use. Summary of the Invention

[0004] The purpose of the present invention is to provide an antibacterial skin protection composition, a preparation method thereof and an application thereof. The antibacterial skin protection composition provided by the present invention uses durian shell essence as the main active ingredient, has good bactericidal and moisturizing effects, and is mild and non-irritating, meeting the needs of modern consumers for healthy skin care products.

[0005] In order to achieve the above purpose, the present invention provides the following technical solutions:

[0006] The present invention provides an antibacterial skin protection composition, comprising the following components in parts by mass:

[0007] 10 - 25 parts of durian shell extraction essence, 3 - 12 parts of coconut oil, 2 - 5 parts of sorbitol, 3 - 8 parts of glycerol, 3 - 7 parts of polyvinyl alcohol, 2 - 3 parts of decamethylcyclopentasiloxane, 6 - 12 parts of 1,2-propanediol, 4 - 10 parts of cetyl alcohol, 3 - 9 parts of glycerol monostearate;

[0008] The durian shell extraction essence is obtained by successively subjecting the durian shell to heating under reflux, cold pressing extraction, water leaching and subcritical water extraction.

[0009] Preferably, the preparation method of the durian shell extraction essence comprises the following steps:

[0010] The durian shell is heated under reflux with an ethanol-water solvent, and after solid-liquid separation, a pretreatment solution is obtained;

[0011] The pretreatment solution is successively concentrated, dried, and pulverized to obtain the pretreated durian shell powder;

[0012] The pretreated durian shell powder is subjected to cold pressing extraction to obtain a cold pressing extraction product;

[0013] The cold pressing extraction product is dissolved in water, and then successively subjected to subcritical water extraction and water removal to obtain the durian shell extraction essence.

[0014] Preferably, the volume content of ethanol in the ethanol-water solvent is 80-85%; the mass ratio of the durian shell to the ethanol-water solvent is 1-2:55; the temperature of the heating reflux is 95-105°C, and the time is 30-40 min.

[0015] Preferably, the drying temperature is 55-65°C; the moisture content of the dried product is 8-10%;

[0016] The particle size of the pretreated durian shell powder is 2-5 mm;

[0017] Preferably, the temperature of the cold pressing extraction is 30-36°C, the pressure is 20-25 MPa, and the time is 1-2 h.

[0018] Preferably, the mass ratio of the cold pressing extraction product to water is 1:8-16; the dissolution time is 2-6 h.

[0019] Preferably, the temperature of the subcritical water extraction is 35-42°C, the pressure is 22-35 MPa, and the time is 1-3 h.

[0020] Preferably, it further includes 40-50 parts of water.

[0021] The present invention provides a preparation method of the antibacterial skin protection composition described in the above technical solution, including the following steps:

[0022] The durian shell extract, coconut oil, and cetyl alcohol are mixed to obtain an oil phase;

[0023] Glycerol and 1,2-propanediol are mixed to obtain an aqueous phase;

[0024] The oil phase, aqueous phase, and the remaining components of the antibacterial skin protection composition are mixed to obtain a mixture;

[0025] The mixture is emulsified to prepare the antibacterial skin protection composition.

[0026] The present invention provides the application of the antibacterial skin protection composition described in the above technical solution or the antibacterial skin protection composition prepared by the preparation method described in the above technical solution in skin care products.

[0027] The present invention provides an antibacterial skin protection composition, comprising the following components in parts by mass: 10-25 parts of durian shell extraction essence, 3-12 parts of coconut oil, 2-5 parts of sorbitol, 3-8 parts of glycerol, 3-7 parts of polyvinyl alcohol, 2-3 parts of decamethylcyclopentasiloxane, 6-12 parts of 1,2-propanediol, 4-10 parts of cetyl alcohol, and 3-9 parts of glycerol monostearate; the durian shell extraction essence is obtained by subjecting durian shells to heat reflux, cold pressing extraction, water leaching, and subcritical water extraction in sequence. The antibacterial skin protection composition provided by the present invention uses durian shell essence as the main active ingredient, and is combined with coconut oil, sorbitol, glycerol, polyvinyl alcohol, decamethylcyclopentasiloxane, 1,2-propanediol, cetyl alcohol, and glycerol monostearate. At the same time, the mass ratio relationship between the above components is reasonably set, and the obtained composition product has a good bactericidal effect, and the pH value is appropriate, mild and non-irritating, and can emit a natural and fresh aroma, meeting the needs of modern consumers for healthy skin care products.

[0028] Moreover, the formula of the antibacterial skin protection composition provided by the present invention does not contain synthetic preservatives or fragrances, reflecting the concept of natural and additive-free, and meeting the needs of modern consumers for healthy skin care products. In addition, the present invention makes full use of durian shell resources, not only solving the problem of waste treatment, but also using the residues generated in the extraction process as soil compost, fuel or bioactive carbon, thereby improving soil quality. This practice realizes the maximum utilization of resources and makes a positive contribution to environmental protection.

[0029] Further, in the present invention, the preparation method of the durian shell extraction essence comprises the following steps: heating and refluxing the durian shells with an ethanol-water solvent, and performing solid-liquid separation to obtain a pretreatment solution; concentrating, drying, and pulverizing the pretreatment solution in sequence to obtain pretreated durian shell powder; subjecting the pretreated durian shell powder to cold pressing extraction to obtain a cold pressing extraction product; leaching the cold pressing extraction product with water, and then performing subcritical water extraction and water removal in sequence to obtain the durian shell extraction essence. By controlling the preparation method of the durian shell extraction essence, the obtained durian shell extraction essence contains various active components, including polysaccharides, flavonoids, alkaloids, phenolic compounds, etc., and can effectively optimize the pH value and antibacterial effect of the antibacterial skin protection composition. Specific Embodiments

[0030] The present invention provides an antibacterial skin protection composition, comprising the following components in parts by mass:

[0031] 10-25 parts of durian shell extraction essence, 3-12 parts of coconut oil, 2-5 parts of sorbitol, 3-8 parts of glycerol, 3-7 parts of polyvinyl alcohol, 2-3 parts of decamethylcyclopentasiloxane, 6-12 parts of 1,2-propanediol, 4-10 parts of cetyl alcohol, and 3-9 parts of glycerol monostearate;

[0032] The durian shell extraction essence is obtained by subjecting the durian shell to heat reflux, cold pressing extraction, water dissolution, and subcritical water extraction in sequence.

[0033] In the present invention, unless otherwise specified, all preparation raw materials / components are commercially available products well-known to those skilled in the art.

[0034] By mass, the antibacterial skin protection composition provided by the present invention comprises 10 to 25 parts of durian shell extraction essence, which can be 10 parts, 15 parts, 20 parts, or 25 parts in the examples. The durian shell extraction essence is obtained by subjecting the durian shell to heat reflux, cold pressing extraction, water dissolution, and subcritical water extraction in sequence.

[0035] In the present invention, the preparation method of the durian shell extraction essence preferably comprises the following steps:

[0036] Heat reflux the durian shell with an ethanol-water solvent, and obtain a pretreatment solution after solid-liquid separation;

[0037] Concentrate, dry, and pulverize the pretreatment solution in sequence to obtain durian shell pretreatment powder;

[0038] Subject the durian shell powder pretreatment powder to cold pressing extraction to obtain a cold pressing extraction product;

[0039] Dissolve the cold pressing extraction product in water, and then perform subcritical water extraction and water removal in sequence to obtain the durian shell extraction essence.

[0040] In the present invention, heat reflux the durian shell with an ethanol-water solvent, and obtain a pretreatment solution after solid-liquid separation. In the present invention, before the heat reflux, the present invention preferably performs pretreatment on the durian shell, and the pretreatment preferably comprises drying and cutting in sequence. The present invention has no special requirements for the specific implementation manner of the pretreatment. The volume content of ethanol in the ethanol-water solvent is preferably 80 to 85%. The mass ratio of the durian shell to the ethanol-water solvent is preferably 1 to 2:55, which can be 2:55 in the examples. The temperature of the heat reflux is preferably 95 to 105 °C, and the time is preferably 30 to 40 min.

[0041] In the present invention, the temperature of the heating reflux should not be too high. During the preparation of the essence extracted from durian shells, if the temperature of the heating reflux is too high, it will cause damage to the active ingredients: some active ingredients in the essence extracted from durian may be sensitive to temperature. If the reflux temperature is too high, these active ingredients may be damaged or decomposed, resulting in an unsatisfactory extraction effect. Moreover, when the temperature of the heating reflux is too high, reaction by-products will form: at high temperatures, some reaction by-products may form, especially if the reactants or raw materials contain unstable components. These by-products may compete with or interfere with the target extract during the extraction process, leading to incomplete extraction.

[0042] In the present invention, when the heating reflux time is too short: the active ingredients are not fully extracted, resulting in insufficient concentration of the active ingredients and poor antibacterial effect. When the heating reflux time is too long: the active ingredients may decompose due to long-term exposure to high temperature, oxygen or solvent, such as polyphenol oxidation and flavonoid degradation. In addition, more impurities may be extracted, interfering with the antibacterial effect or producing an antagonistic effect. At the same time, long-term extraction increases costs and may not be economical.

[0043] In the present invention, the solid-liquid separation is carried out on the material obtained after the heating reflux. The specific implementation manner of the solid-liquid separation is preferably filtration. The filtrate obtained by filtration is the pretreatment solution.

[0044] After obtaining the pretreatment solution, the present invention sequentially concentrates, dries and pulverizes the pretreatment solution to obtain the pretreated durian shell powder. In the present invention, the concentration is preferably vacuum concentration. The concentrated product is a paste. The present invention preferably dries the paste. The drying is preferably drying by baking, and the drying temperature is 55-65°C, which can be 60°C in the examples; the moisture content of the dried product is 8-10%. The present invention preferably pulverizes the dried product. The particle size of the pretreated durian shell powder is 2-5 mm.

[0045] After obtaining the pretreated durian shell powder, the present invention performs cold pressing extraction on the pretreated durian shell powder to obtain a cold pressing extraction product. In the present invention, the cold pressing extraction is preferably carried out in a cold pressing extraction device. The temperature of the cold pressing extraction is preferably 30-36°C, which can be 36°C in the examples, the pressure is preferably 20-25 MPa, which can be 25 MPa in the examples, and the time is preferably 1-2 h, which can be 2 h in the examples. By performing cold pressing extraction on the pretreated durian shell powder and controlling the operating conditions of the cold pressing extraction, the present invention can effectively release the nutrients in the durian shell, including its essence components.

[0046] After obtaining the cold pressing extraction product, the present invention dissolves the cold pressing extraction product in water, and then successively performs subcritical water extraction and water removal to obtain the durian shell extraction essence. In the present invention, the mass ratio of the cold pressing extraction product to water is preferably 1:8 to 16, and can be 1:10 in the examples. The temperature of the dissolution is preferably room temperature. The time of the dissolution is preferably 2 to 6 h, and can be 5 h in the examples. The subcritical water extraction is preferably carried out in a subcritical water extraction device. The temperature of the subcritical water extraction is preferably 35 to 42 °C, and can be 35 °C, 36 °C, 37 °C, 38 °C, 42 °C in the examples; the pressure is preferably 22 to 26.5 MPa, and can be 25 MPa in the examples; the time is preferably 1 to 3 h, and can be 2 h, 2.5 h or 3 h in the examples. In the present invention, too high a temperature of subcritical water extraction will cause the active ingredients of the durian shell to be destroyed. Oxidation reactions are more likely to occur.

[0047] In the present invention, the water removal preferably includes: successively performing vacuum distillation and water removal with anhydrous sodium sulfate on the solution obtained by subcritical water extraction. The pressure of the vacuum distillation is preferably 50 to 60 KPa. The temperature is preferably 75 to 80 °C, and the time is preferably 1 to 1.5 h.

[0048] The present invention uses durian shells as raw materials, and the obtained durian shell extraction essence is obtained from plant raw materials. This natural ingredient has much less allergenicity than products added with artificial chemical components. The antibacterial skin protection composition prepared by the present invention using the durian shell extraction essence can achieve multiple effects such as moisturizing, anti-aging, whitening and soothing, and at the same time, its mildness can also reduce the negative impact on the skin. The present invention uses the durian shell extraction essence to prepare an antibacterial skin protection composition, which can provide consumers with a more natural and mild skin care option.

[0049] Based on the durian shell extraction essence, the antibacterial skin protection composition provided by the present invention includes 3 to 12 parts of coconut oil, preferably 4 to 10 parts, and can be 5 parts in the examples. In the present invention, the functions of the coconut oil in the antibacterial skin protection composition include: moisturizing and nourishing, anti-aging and reducing damage, and soothing skin inflammation.

[0050] Based on the durian shell extraction essence, the antibacterial skin protection composition provided by the present invention includes 2 to 5 parts of sorbitol, preferably 2.5 to 4 parts, and can be 3 parts in the examples. In the present invention, the functions of the sorbitol in the antibacterial skin protection composition include: moisturizing, antioxidant and promoting skin barrier repair.

[0051] Based on the durian shell extract essence, the antibacterial skin protection composition provided by the present invention comprises 3 to 8 parts of glycerol, preferably 4 to 7 parts, and may be 6 parts in the examples. In the present invention, the role of the glycerol in the antibacterial skin protection composition includes: moisturizing.

[0052] Based on the durian shell extract essence, the antibacterial skin protection composition provided by the present invention comprises 3 to 7 parts of polyvinyl alcohol (PVA), preferably 4 to 6 parts, and may be 5 parts in the examples. In the present invention, the roles of the polyvinyl alcohol in the antibacterial skin protection composition include: moisturizing, antioxidant, preventing skin allergies, exfoliating, and improving skin condition.

[0053] Based on the durian shell extract essence, the antibacterial skin protection composition provided by the present invention comprises 2 to 3 parts of decamethylcyclopentasiloxane, and may be 2 parts in the examples. In the present invention, the roles of the decamethylcyclopentasiloxane in the antibacterial skin protection composition include: moisturizing, moisturizing, and protecting skin mucosa. In the present invention, the molecular formula of the decamethylcyclopentasiloxane is C 10 H 30 O5Si5.

[0054] Based on the durian shell extract essence, the antibacterial skin protection composition provided by the present invention comprises 6 to 12 parts of 1,2 - propanediol, preferably 6 to 10 parts, and may be 6 parts in the examples. In the present invention, the roles of the 1,2 - propanediol in the antibacterial skin protection composition include: moisturizer, antibacterial agent, and solvent.

[0055] Based on the durian shell extract essence, the antibacterial skin protection composition provided by the present invention comprises 4 to 10 parts of cetyl alcohol, preferably 5 to 8 parts, and may be 7 parts in the examples. In the present invention, the roles of the cetyl alcohol in the antibacterial skin protection composition include: emulsifying, thickening, and moisturizing.

[0056] Based on the durian shell extract essence, the antibacterial skin protection composition provided by the present invention comprises 3 to 9 parts of glyceryl monostearate, preferably 4 to 8 parts, and may be 5 parts in the examples. In the present invention, the roles of the glyceryl monostearate in the antibacterial skin protection composition include: moisturizing, emulsifying, stabilizing, and improving skin texture. In the present invention, the molecular formula of the glyceryl monostearate is C 21 H 42 O4.

[0057] Based on the durian shell extract essence, the antibacterial skin protection composition provided by the present invention preferably further comprises 40 to 50 parts of water, and may be 50 parts in the examples. In the present invention, the water is preferably deionized water. In the present invention, the role of the water in the antibacterial skin protection composition includes: solvent.

[0058] The present invention provides a method for preparing the antibacterial skin protection composition described in the above technical solution, comprising the following steps:

[0059] Mix the durian shell extract, coconut oil and cetyl alcohol to obtain an oil phase;

[0060] Mix glycerol and 1,2 - propanediol to obtain an aqueous phase;

[0061] Mix the oil phase, the aqueous phase and the remaining components of the antibacterial skin protection composition to obtain a mixture;

[0062] Emulsify the mixture to prepare the antibacterial skin protection composition.

[0063] The present invention mixes the durian shell extract, coconut oil and cetyl alcohol to obtain an oil phase. The present invention has no special requirements for the preparation process of the oil phase.

[0064] The present invention mixes glycerol and 1,2 - propanediol to obtain an aqueous phase. The present invention has no special requirements for the preparation process of the aqueous phase.

[0065] After obtaining the oil phase and the aqueous phase, the present invention mixes the oil phase, the aqueous phase and the remaining components of the antibacterial skin protection composition to obtain a mixture. In the present invention, the remaining components include glyceryl monostearate, polyvinyl alcohol (PVA), sorbitol and decamethylcyclopentasiloxane; preferably include glyceryl monostearate, polyvinyl alcohol (PVA), sorbitol, decamethylcyclopentasiloxane and water. The mixing of the oil phase, the aqueous phase and the remaining components of the antibacterial skin protection composition is preferably carried out under the conditions of heating and stirring, the temperature of the mixing is preferably 60 - 80 °C, and after the heating and stirring is completed, it is left to stand and cool to room temperature to obtain the mixture.

[0066] After obtaining the mixture, the present invention emulsifies the mixture to prepare the antibacterial skin protection composition. The emulsification treatment is preferably carried out in an emulsifier, and the rotation speed of the emulsification treatment is preferably 1000 - 2000 revolutions per minute. The present invention has no special requirements for the specific implementation manner of the emulsification.

[0067] The present invention provides the application of the antibacterial skin protection composition described in the above technical solution or the antibacterial skin protection composition prepared by the preparation method described in the above technical solution in skin care products.

[0068] In the present invention, the skin care product can specifically be a body lotion product.

[0069] In order to further illustrate the present invention, the technical solution provided by the present invention will be described in detail below in conjunction with examples, but they cannot be understood as limiting the protection scope of the present invention.

[0070] Example 1

[0071] This example provides a method for preparing the essence extracted from durian shells:

[0072] Step S1: Dry the durian shells and then cut them into small pieces. Mix an ethanol - water solvent with an ethanol volume content of 80 wt% with the dried durian shell pieces in a mass ratio of 55:2. Heat - reflux at 95°C for 40 min. Filter the material obtained after heat - reflux, concentrate the filtrate under reduced pressure to obtain a durian shell extract. Place the durian shell extract in an oven and dry it at 60°C until the moisture content drops to 8 wt%. Subsequently, use a pulverizer to grind it into a powder with a particle size of 2 mm to obtain durian shell extract powder.

[0073] Step S2: Place the durian shell extract powder obtained in the above step S1 in a cold - pressing extraction device. Set the temperature to 36°C, control the pressure at 25 MPa, and the extraction time is 2 h. This process can effectively release the nutrients in the durian shells, including its essence components, to obtain a cold - pressing extraction product.

[0074] Step S3: Mix the cold - pressing extraction product obtained in step S2 with water in a mass ratio of 1:10, then perform water leaching for 5 h, and then put it into a sub - critical water extraction device. Extract at 37°C and 25 MPa for 3 h to obtain a durian shell extract solution. Finally, subject the durian shell extract solution to reduced - pressure distillation (pressure is 50 KPa, temperature is 80°C, time is 1 h) and then dry it with anhydrous sodium sulfate to obtain the essence extracted from durian shells.

[0075] This example also provides an antibacterial body lotion product, which includes the following raw materials for preparation in parts by mass: 10 parts of the essence extracted from durian shells, 5 parts of coconut oil, 3 parts of sorbitol, 6 parts of glycerol, 5 parts of polyvinyl alcohol (PVA), 2 parts of decamethylcyclopentasiloxane, 6 parts of 1,2 - propanediol, 7 parts of cetyl alcohol, 5 parts of glycerol monostearate, and 50 parts of deionized water.

[0076] This example also provides a method for preparing an antibacterial body lotion product, which includes the following steps:

[0077] First, mix the essence extracted from durian shells with coconut oil and cetyl alcohol to form an oil phase; secondly, mix glycerol and 1,2 - propanediol to form an aqueous phase; after mixing the above - mentioned oil phase and aqueous phase, add glycerol monostearate, polyvinyl alcohol (PVA), sorbitol, decamethylcyclopentasiloxane, and deionized water. Heat and stir at 80°C and then cool and stand to form a mixture; finally, emulsify the mixture through an emulsifier until the mixture presents a uniform and delicate milky - white paste to obtain the antibacterial body lotion containing the essence extracted from durian shells.

[0078] Example 2

[0079] This embodiment provides a method for preparing a durian shell extract:

[0080] Step S1: Durian shell is dried and then cut into small pieces, and the ethanol water solvent with an ethanol volume content of 80wt% and the durian shell small pieces obtained after drying are mixed according to the mass ratio of the ethanol water solvent to the durian shell small pieces of 55:2, and heated to reflux for 40min under 95°C. The material obtained after heating and reflux is filtered, and the filtrate is concentrated under reduced pressure to obtain durian shell extract. The durian shell extract is placed in an oven and dried at 60°C until the moisture content is reduced to 8wt%, and then ground into a powder of 2mm using a pulverizer to obtain durian shell extract powder.

[0081] Step S2: The durian shell extract powder obtained in the above step S1 is placed in a cold press extraction device, the temperature is set to 36°C, the pressure is controlled at 25MPa, and the extraction time is 2h. This process can effectively release the nutrients in the durian shell, including its essence, to obtain a cold press extraction product.

[0082] Step S3: The cold-pressed extraction product obtained in step S2 is mixed with water in a mass ratio of 1:10, then soaked in water for 5 hours, and then placed in a subcritical water extraction device, extracted for 2 hours at 36°C and 25MPa to obtain a durian shell extract. Finally, the durian shell extract is vacuum distilled (pressure is 50KPa, temperature is 80°C, time is 1 hour) and then dried with anhydrous sodium sulfate to obtain a durian shell extract.

[0083] The present embodiment also provides an antibacterial body lotion product, comprising the following raw materials calculated in parts by mass: 15 parts of durian shell extract, 5 parts of coconut oil, 3 parts of sorbitol, 6 parts of glycerol, 5 parts of polyvinyl alcohol (PVA), 2 parts of decamethylcyclopentasiloxane, 6 parts of 1,2-propylene glycol, 7 parts of hexadecyl alcohol, 5 parts of glyceryl monostearate and 50 parts of deionized water.

[0084] This embodiment also provides a method for preparing an antibacterial body lotion product, comprising the following steps:

[0085] First, the durian shell extract is mixed with coconut oil and hexadecyl alcohol to prepare an oil phase; secondly, glycerol and 1,2-propylene glycol are mixed to prepare an aqueous phase; after mixing the above oil phase and aqueous phase, glyceryl monostearate, polyvinyl alcohol (PVA), sorbitol, decamethylcyclopentasiloxane and deionized water are added, and the mixture is heated and stirred at 80°C and then cooled and allowed to stand to form a mixture; finally, the mixture is emulsified by an emulsifier until the mixture presents a uniform and delicate milky white paste, thereby obtaining an antibacterial body lotion containing durian shell extract.

[0086] Example 3

[0087] This embodiment provides a method for preparing the essence extracted from durian shells:

[0088] Step S1: Dry the durian shells, then cut them into small pieces. Mix an ethanol-water solvent with an ethanol volume content of 80 wt% with the dried durian shell pieces in a mass ratio of 55:2, and heat under reflux at 95 °C for 40 min. Filter the material obtained after heating under reflux, concentrate the filtrate under reduced pressure to obtain a durian shell extract. Place the durian shell extract in an oven and dry it at 60 °C until the moisture content drops to 8 wt%, and then use a pulverizer to grind it into a powder with a particle size of 2 mm to obtain a durian shell extract powder.

[0089] Step S2: Place the durian shell extract powder obtained in the above step S1 in a cold pressing extraction device, set the temperature to 36 °C, control the pressure at 25 MPa, and the extraction time is 2 h. This process can effectively release the nutrients in the durian shells, including its essence components, to obtain a cold pressing extraction product.

[0090] Step S3: Mix the cold pressing extraction product obtained in step S2 with water in a mass ratio of 1:10, then perform water leaching for 5 h, put it into a subcritical water extraction device, and extract at 37 °C and 25 MPa for 2.5 h to obtain a durian shell extract solution. Finally, subject the durian shell extract solution to vacuum distillation (pressure is 50 KPa, temperature is 80 °C, time is 1 h), and then dry it with anhydrous sodium sulfate to obtain the essence extracted from durian shells.

[0091] This embodiment also provides an antibacterial body lotion product, which includes the following raw materials for preparation calculated by mass fraction: 20 parts of the essence extracted from durian shells, 5 parts of coconut oil, 3 parts of sorbitol, 6 parts of glycerol, 5 parts of polyvinyl alcohol (PVA), 2 parts of decamethylcyclopentasiloxane, 6 parts of 1,2 - propanediol, 7 parts of cetyl alcohol, 5 parts of glycerol monostearate, and 50 parts of deionized water.

[0092] This embodiment also provides a method for preparing an antibacterial body lotion product, which includes the following steps:

[0093] First, mix the essence extracted from durian shells with coconut oil and cetyl alcohol to form an oil phase; secondly, mix glycerol and 1,2 - propanediol to form an aqueous phase; after mixing the above oil phase and aqueous phase, add glycerol monostearate, polyvinyl alcohol (PVA), sorbitol, decamethylcyclopentasiloxane, and deionized water, heat and stir at 80 °C, then cool and stand to form a mixture; finally, emulsify the mixture through an emulsifier until the mixture presents a uniform and delicate milky white paste to obtain an antibacterial body lotion containing the essence extracted from durian shells.

[0094] Example 4

[0095] This embodiment provides a method for preparing the essence extracted from durian shells:

[0096] Step S1: Dry the durian shells, then cut them into small pieces. Mix an ethanol-water solvent with an ethanol volume content of 80 wt% with the small pieces of dried durian shells in a mass ratio of 55:2, and heat under reflux at 95 °C for 40 min. Filter the material obtained after heating under reflux, and concentrate the filtrate under reduced pressure to obtain a durian shell extract. Place the durian shell extract in an oven and dry it at 60 °C until the water content drops to 8 wt%, and then use a pulverizer to grind it into a powder with a particle size of 2 mm to obtain a durian shell extract powder.

[0097] Step S2: Place the durian shell extract powder obtained in the above step S1 in a cold pressing extraction device, set the temperature to 36 °C, control the pressure at 25 MPa, and the extraction time is 2 h. This process can effectively release the nutrients in the durian shells, including its essence components, to obtain a cold pressing extraction product.

[0098] Step S3: Mix the cold pressing extraction product obtained in step S2 with water in a mass ratio of 1:10, then carry out water leaching for 5 h, put it into a subcritical water extraction device, and extract for 3 h under the conditions of 42 °C and 25 MPa to obtain a durian shell extract solution. Finally, subject the durian shell extract solution to vacuum distillation (pressure is 50 KPa, temperature is 80 °C, time is 1 h) and then dry it with anhydrous sodium sulfate to obtain the essence extracted from durian shells.

[0099] This embodiment also provides an antibacterial body lotion product, which includes the following raw materials for preparation calculated by mass fraction: 25 parts of the essence extracted from durian shells, 5 parts of coconut oil, 3 parts of sorbitol, 6 parts of glycerol, 5 parts of polyvinyl alcohol (PVA), 2 parts of decamethylcyclopentasiloxane, 6 parts of 1,2 - propanediol, 7 parts of cetyl alcohol, 5 parts of glycerol monostearate, and 50 parts of deionized water.

[0100] This embodiment also provides a method for preparing an antibacterial body lotion product, which includes the following steps:

[0101] First, mix the essence extracted from durian shells with coconut oil and cetyl alcohol to form an oil phase; secondly, mix glycerol and 1,2 - propanediol to form an aqueous phase; after mixing the above oil phase and aqueous phase, add glycerol monostearate, polyvinyl alcohol (PVA), sorbitol, decamethylcyclopentasiloxane, and deionized water, heat and stir at 80 °C and then cool and stand to form a mixture; finally, emulsify the mixture through an emulsifier until the mixture presents a uniform and delicate milky white paste to prepare an antibacterial body lotion containing the essence extracted from durian shells.

[0102] Example 5

[0103] This embodiment provides a method for preparing the essence extracted from durian shells:

[0104] Step S1: Dry the durian shells, then cut them into small pieces. Mix an ethanol-water solvent with an ethanol volume content of 80 wt% with the dried durian shell pieces in a mass ratio of 55:2. Heat under reflux at 95 °C for 40 min. Filter the material obtained after heating under reflux, and concentrate the filtrate under reduced pressure to obtain a durian shell extract. Place the durian shell extract in an oven and dry it at 60 °C until the moisture content drops to 8 wt%. Subsequently, use a pulverizer to grind it into a powder with a particle size of 2 mm to obtain a durian shell extract powder.

[0105] Step S2: Place the durian shell extract powder obtained in the above step S1 in a cold pressing extraction device. Set the temperature to 36 °C, control the pressure at 25 MPa, and the extraction time is 2 h. This process can effectively release the nutrients in the durian shells, including its essence components, to obtain a cold pressing extraction product.

[0106] Step S3: Mix the cold pressing extraction product obtained in step S2 with water in a mass ratio of 1:10, then perform water leaching for 5 h, and then put it into a subcritical water extraction device. Extract at 36 °C and 25 MPa for 3 h to obtain a durian shell extract solution. Finally, subject the durian shell extract solution to vacuum distillation (pressure: 50 KPa, temperature: 80 °C, time: 1 h), and then dry it with anhydrous sodium sulfate to obtain the essence extracted from durian shells.

[0107] This embodiment also provides an antibacterial body lotion product, which includes the following raw materials for preparation calculated by mass fraction: 25 parts of the essence extracted from durian shells, 5 parts of coconut oil, 3 parts of sorbitol, 6 parts of glycerol, 5 parts of polyvinyl alcohol (PVA), 2 parts of decamethylcyclopentasiloxane, 6 parts of 1,2-propanediol, 7 parts of cetyl alcohol, 5 parts of glycerol monostearate, and 50 parts of deionized water.

[0108] This embodiment also provides a method for preparing an antibacterial body lotion product, which includes the following steps:

[0109] First, mix the essence extracted from durian shells with coconut oil and cetyl alcohol to form an oil phase; secondly, mix glycerol and 1,2-propanediol to form an aqueous phase; after mixing the above oil phase and aqueous phase, add glycerol monostearate, polyvinyl alcohol (PVA), sorbitol, decamethylcyclopentasiloxane, and deionized water. After heating and stirring at 80 °C, cool and let stand to form a mixture; finally, emulsify the mixture through an emulsifier until the mixture presents a uniform and delicate milky white paste to prepare an antibacterial body lotion containing the essence extracted from durian shells.

[0110] Comparative Example 1

[0111] The antibacterial body lotion provided in Comparative Example 1 is basically the same as that in Example 3, except that the amount of the durian shell extract added is 5 parts.

[0112] Comparative Example 2

[0113] The antibacterial body lotion provided in Comparative Example 2 is basically the same as that in Example 3, except that the amount of the durian shell extract added is 50 parts.

[0114] Comparative Example 3

[0115] The preparation method of the durian shell extract provided in Comparative Example 3 is basically the same as that in Example 3, except that the reflux temperature in Step S1 is 80°C.

[0116] Comparative Example 4

[0117] The preparation method of the durian shell extract provided in Comparative Example 4 is basically the same as that in Example 3, except that the reflux temperature in Step S1 is 120°C.

[0118] Comparative Example 5

[0119] The preparation method of the durian shell extract provided in Comparative Example 5 is basically the same as that in Example 3, except that in the subcritical water extraction equipment in Step S3, extraction is carried out for 0.5 h under the conditions of 37°C and 25 MPa.

[0120] Comparative Example 6

[0121] The preparation method of the durian shell extract provided in Comparative Example 6 is basically the same as that in Example 3, except that in the subcritical water extraction equipment in Step S3, extraction is carried out for 5 h under the conditions of 37°C and 25 MPa.

[0122] Test Example

[0123] The antibacterial body lotion products prepared in Examples 1 - 5 of the present invention and Comparative Examples 1 - 6 all passed the pH test and the antibacterial test.

[0124] (1) During the pH test of the antibacterial body lotion product, the operation is carried out according to the following steps:

[0125] First, pour the antibacterial body lotion product into a clean container. Immerse the pH meter into the body lotion, ensure that the probe covers enough liquid surface, and read the corresponding value. Compare the obtained result with the ideal pH range that the body lotion should have (usually around 5.5). The test results are shown in Table 1. Table 1 shows that the pH value of the product prepared in Example 3 is in the most ideal state, the pH values of the products prepared in Comparative Example 2, Comparative Example 3, and Comparative Example 5 are lower, and the pH value of the product prepared in Comparative Example 6 is higher.

[0126] Table 1 Comparison of pH Values of Products Prepared in Examples 1 - 5 and Comparative Examples 1 - 6

[0127]

[0128] As can be seen from the data in Table 1, the antibacterial body lotion product obtained in Example 3 has the best pH value effect. However, too high or too low temperature of heating under reflux has a certain impact on the effective components of durian extract, resulting in too high or too low pH value of the antibacterial body lotion product.

[0129] (2) During the bacteriostatic test, a composite solidified medium containing tryptic soy broth liquid medium (TSB) and mannitol salt agar (MSA) was prepared, and the method for forming a bacteriostatic zone is as follows:

[0130] First, pour 200 mL of deionized water into a conical flask, and add 5.2 g of TSB. After stirring well, add 15 g of sodium chloride and 5 g of mannitol salt agar (MSA) powder, and stir well.

[0131] For the sterilization process, the pipette tips and pipettes need to be wrapped with newspaper and placed in a steam sterilizer for 3 h at a high temperature of 130 °C. After the sterilization is completed, the pipette tips and pipettes need to be quickly placed in an oven to remove moisture and wait for them to cool before use.

[0132] Before performing the bacterial inoculation operation, first place the inoculation loop in the ultra-clean workbench and turn on the ultraviolet irradiator for irradiation for 1 h. Take out the staphylococcus strain from the -70 °C refrigerator, place it on an ice box and spray alcohol, then spray alcohol onto the culture medium and put it into the workbench. Burn the inoculation loop in the flame three times, and after cooling, dip a small amount of bacterial liquid onto the inoculation loop, and then inoculate it into the culture medium. Plug in the stopper, place the culture medium in a shaker and culture it for 24 h, and measure the concentration of bacteria to ensure that it reaches 10 6 ~10 8 CFU / mL before performing the bacterial spreading operation.

[0133] When starting the pour plate operation, first wait for the ultraviolet irradiation of the ultra-clean workbench for 30 min. Spray alcohol onto the hot composite solidified medium and disposable culture dishes, and place them in the ultra-clean workbench. Wait for the temperature to drop to 40 - 70 °C before starting the pour plate. Pour 10 - 15 mL of the culture medium into each plate. After it solidifies, invert the plate and place it in an incubator at 37.2 °C for 48 hours, and observe whether there is any contamination phenomenon.

[0134] Before performing the antibacterial zone operation, first place the sterilized pipette tips and pipettes in the laminar flow hood and irradiate them with ultraviolet light for 30 minutes. Subsequently, spray alcohol onto the bacterial liquid culture bottles, petri dishes, disposable spreading rods, sterilized filter paper discs, and forceps, and place them in the laminar flow hood. Use a pipette to aspirate 100 μL of the bacterial liquid onto the petri dish and spread it evenly with a spreading rod. Use forceps to pick up a filter paper disc with a diameter of 10 mm, soak it in the samples of Examples 1-5 and Comparative Examples 1-6, and then place it in the center of the bacterial plate and let it stand for absorption. After that, invert the culture plate and place it in an incubator at 37.2 °C for 48 hours. Take it out and observe, and use a ruler to measure the size of the antibacterial zone. The test results are shown in Table 2. The product prepared in Example 3 in Table 2 has the largest antibacterial zone size. Although the products prepared in Comparative Example 2 and Comparative Example 6 have relatively large antibacterial zone sizes, the pH values of the products prepared by the two are much lower.

[0135] Table 2 Comparison of the antibacterial zone sizes of the products prepared in Examples 1-5 and Comparative Examples 1-6

[0136]

[0137]

[0138] It can be seen from the test results in Table 1 and Table 2 that compared with Example 3: If too little durian shell extract essence is added (Comparative Example 1), causing the pH value of the body lotion to be too high (alkaline) within the normal range, it will damage the acidic protective film of the skin, resulting in discomfort symptoms such as dermatitis, skin redness, pain or burning sensation, dryness, and peeling. For consumers with particularly sensitive skin or certain skin problems such as eczema and psoriasis, the symptoms may be aggravated. If too much durian shell extract essence is added (Comparative Example 2), causing the pH value of the body lotion to be too low (acidic) within the normal range: it will cause skin discomfort, such as dryness, tightness, and allergic reactions. Extremely acidic products may cause burns to the skin, especially when used undiluted.

[0139] The reflux temperature in Comparative Example 4 was too high, resulting in the destruction of temperature-sensitive components in the durian shell extract essence, a decrease in the extraction rate, and an increase in the pH value, which may affect the stability and shelf life of the product. A too high pH value may lead to unstable emulsification, emulsion stratification, and damage to the product texture. At the same time, under high pH values, it is easy to cultivate some harmful microorganisms, affecting the shelf life of the product. The pH value of most skin care products is usually around 5.5 because the natural pH value of the human skin surface is about 4.7-5.75. If the pH value of a product is too low (too acidic) such as in Comparative Example 3, it may cause skin allergic reactions.

[0140] In the present invention, the antibacterial performance of the body lotion product is related to factors such as the level of pH value, the amount of durian shell extract essence, the reflux temperature, and the extraction time. The pH value is an important environmental factor that directly affects the growth and activity of bacteria. When the pH value decreases (becomes acidic), the growth of many bacteria will be inhibited, but there are also some specific types of bacteria that prefer an acidic environment. Certain phenolic substances and carbohydrate substances in the durian shell can inhibit the growth of specific types of microorganisms, but if the pH is too low, the effectiveness of these substances may be weakened. Within a certain range, increasing the amount of durian shell extract essence can indeed improve the antibacterial performance. However, when a certain concentration is reached, further increasing the addition amount will not significantly increase the antibacterial performance of the product and may have a negative impact on other properties. The reflux temperature in Comparative Example 3 is too low, resulting in low extraction efficiency of the durian shell extract essence; the reflux temperature in Comparative Example 4 is too high, which easily causes damage to the durian shell extract and reduces the extraction effect. Therefore, it is necessary to find an appropriate reflux temperature to maximize the protection and extraction of the active ingredients of the extract. The extraction time in subcritical water extraction in Comparative Example 5 is too short, and the extraction is incomplete, resulting in incomplete extraction of the active ingredients; the extraction time in subcritical water extraction in Comparative Example 6 is too long. In addition to increasing the cost, it may also damage the extract or decompose the active ingredients.

[0141] As can be seen from the above examples, the present invention verifies that the relationships among the antibacterial components, pH value, extraction time, temperature, etc. contained in the durian shell extract essence need to be considered comprehensively. It is necessary to ensure the maximum extraction of active ingredients while avoiding unnecessary cost and time waste. By optimizing the process of the durian shell extract essence, the obtained durian shell extract essence is used as the key composition of the antibacterial skin protection composition. The obtained antibacterial skin protection composition has good bactericidal and moisturizing effects, is mild and non-irritating, can emit a natural and fresh aroma, and meets the needs of modern consumers for healthy skin care products.

[0142] Although the above examples have described the present invention in detail, they are only a part of the embodiments of the present invention, not all embodiments. Other embodiments can also be obtained based on these embodiments without creative efforts, and these embodiments all fall within the protection scope of the present invention.

Claims

1. An antibacterial skin protection composition, characterized in that The composition includes the following components in parts by weight: 10-25 parts of durian shell extract, 3-12 parts of coconut oil, 2-5 parts of sorbitol, 3-8 parts of glycerin, 3-7 parts of polyvinyl alcohol, 2-3 parts of decamethylcyclopentasiloxane, 6-12 parts of 1,2-propylene glycol, 4-10 parts of hexadecyl alcohol, 3-9 parts of glyceryl monostearate; The durian shell extract is obtained by sequentially subjecting the durian shell to heating reflux, cold pressing extraction, water dissolution and subcritical water extraction.

2. The antibacterial skin protection composition according to claim 1, characterized in that The preparation method of the durian shell extract comprises the following steps: The durian shell is heated and refluxed with an ethanol-water solvent to obtain a pretreatment solution after solid-liquid separation; The pre-treated solution is sequentially concentrated, dried and crushed to obtain durian shell pre-treated powder; The durian shell powder pretreatment powder is subjected to cold pressing extraction to obtain a cold pressing extraction product; The cold-pressed extraction product is dissolved in water, and then subjected to subcritical water extraction and water removal in sequence to obtain the durian shell extract essence.

3. The antibacterial skin protection composition according to claim 2, characterized in that The volume content of ethanol in the ethanol-water solvent is 80-85%; the mass ratio of the durian shell to the ethanol-water solvent is 1-2:55; the heating reflux temperature is 95-105° C., and the time is 30-40 minutes.

4. The antibacterial skin protection composition according to claim 2, characterized in that The drying temperature is 55-65°C; the moisture content of the dried product is 8-10%; The particle size of the pretreated durian shell powder is 2 to 5 mm.

5. The antibacterial skin protection composition according to claim 2, characterized in that The temperature of the cold-press extraction is 30-36° C., the pressure is 20-25 MPa, and the time is 1-2 hours.

6. The antibacterial skin protection composition according to claim 2, characterized in that The mass ratio of the cold-pressed extraction product to water is 1:8-16; and the soaking time is 2-6 hours.

7. The antibacterial skin protection composition according to claim 2, characterized in that The subcritical water extraction is performed at a temperature of 35 to 42° C., a pressure of 22 to 26.5 MPa, and a time of 1 to 3 hours.

8. The antibacterial skin protection composition according to claim 1, characterized in that Also include 40 to 50 parts of water.

9. The method for preparing the antibacterial skin protection composition according to any one of claims 1 to 8, characterized in that: The following steps are involved: mixing durian shell extract, coconut oil and cetyl alcohol to obtain an oil phase; Mixing glycerol and 1,2-propylene glycol to obtain an aqueous phase; mixing the oil phase, the water phase and the remaining components of the antimicrobial skin protection composition to obtain a mixture; The mixture is emulsified to prepare the antibacterial skin protection composition.

10. The antibacterial skin protection composition according to any one of claims 1 to 8 Application of the composition or the antibacterial skin protection composition prepared by the preparation method according to claim 9 in skin care products.

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