Skin disinfectant containing disinfection and hemostasis composition and preparation method thereof

Abstract

The invention relates to the field of disinfectants, and provides a skin disinfectant containing a disinfection and hemostasis composition and a preparation method thereof.The skin disinfectant is prepared from, by weight, 60-80 parts of absolute ethyl alcohol, 15-25 parts of the disinfection and hemostasis composition, 0.5-3 parts of modified xanthan gum, 2-6 parts of a softening and moistening agent, 10-20 parts of a composite surfactant and 20-30 parts of deionized water, the composite surfactant is a mixture of dodecenyl succinic acid glucose ester and fatty alcohol-polyoxyethylene ether sulfate. The skin disinfectant provided by the invention has the characteristics of good mildness, stability and disinfection and hemostasis functions.

Description

Technical Field

[0001] The present invention relates to the field of disinfectants, and particularly to a skin disinfectant containing a disinfection and hemostasis composition and a preparation method thereof. Background Art

[0002] In recent years, people have paid more and more attention to protective measures such as sterilization and disinfection in daily life. Some disinfectant products for human skin, such as hand sanitizers, have emerged as the times require. Therefore, a composition with disinfection and hemostasis functions also has good application prospects in skin disinfectants.

[0003] Although adding a disinfection and hemostasis composition to a skin disinfectant can play a good role in sterilization and disinfection and promote the rapid healing of wounds, the skin disinfectant still has some higher requirements when used on human skin. For example, the skin disinfectant should have good mildness, which is particularly important for some people with sensitive skin. And for convenient and long-term storage, the skin disinfectant should also have good stability and emulsifying suspension ability to reduce adverse phenomena such as freeze-thaw when the temperature changes between high and low.

[0004] Patent CN 113599284B discloses a highly efficient and stable hand sanitizer and a preparation method thereof. The hand sanitizer includes a surfactant, an antibacterial agent, a thickener, a softener, a pH regulator, silicone oil and deionized water, and has a wide and efficient sterilization and disinfection effect, and can also effectively protect the skin and keep it moist and eliminate static electricity. However, the thickeners selected in this application include one or more of hydroxycellulose, carbomer, xanthan gum, hyaluronic acid, and carrageenan. Among them, xanthan gum is preferably used as the thickener in the examples. However, the dispersibility and high-temperature resistance of xanthan gum need to be improved, which may lead to poor stability of the hand sanitizer.

[0005] Therefore, there is an urgent need in the market for a skin disinfectant containing a disinfection and hemostasis composition with good mildness and stability. Summary of the Invention

[0006] Aiming at the problems existing in the prior art, the present invention synthesizes a skin disinfectant containing a disinfection and hemostasis composition from raw materials such as anhydrous ethanol, a disinfection and hemostasis composition, modified xanthan gum, a composite surfactant, etc., which has good mildness, stability and disinfection and hemostasis functions.

[0007] In order to achieve the above object, the technical solutions adopted by the present invention are as follows:

[0008] On the one hand, the present invention provides a skin disinfectant containing a disinfection and hemostasis composition, and the skin disinfectant comprises the following raw materials: 60-80 parts of absolute ethanol, 15-25 parts of the disinfection and hemostasis composition, 0.5-3 parts of modified xanthan gum, 2-6 parts of a softening agent, 10-20 parts of a composite surfactant, and 20-30 parts of deionized water, wherein the composite surfactant is a mixture of dodecenyl succinic acid glucose ester and fatty alcohol polyoxyethylene ether sulfate.

[0009] Preferably, the mass ratio of the dodecenyl succinic acid glucose ester to the fatty alcohol polyoxyethylene ether sulfate is 1:(0.5-0.8).

[0010] In some embodiments of the present invention, by weight parts, each part of the disinfection and hemostasis composition comprises the following raw materials: 30-50 parts of a composite antibacterial disinfectant, 1-5 parts of hydrogenated castor oil, 1-3 parts of Codonopsis pilosula, and 2-8 parts of a hemostatic traditional Chinese medicine component.

[0011] In some embodiments of the present invention, the composite antibacterial disinfectant is a mixture of triclosan and modified chitosan, and the mass ratio is 1:(1.5-2.5).

[0012] In some embodiments of the present invention, the preparation method of the modified chitosan comprises the following steps:

[0013] (1) Adding chitosan into an aqueous hydrochloric acid solution, stirring, adding absolute ethanol for precipitation, subjecting the precipitate to reduced-pressure suction filtration, washing, and drying to obtain chitosan hydrochloride for standby;

[0014] (2) Adding the chitosan hydrochloride obtained in step (1) into deionized water, stirring and then adding it into liquid paraffin, stirring at 50-60°C for 20-40 min, adding glutaraldehyde, stirring, washing, centrifuging, and drying to obtain chitosan hydrochloride microspheres for standby;

[0015] (3) Adding the chitosan hydrochloride microspheres obtained in step (2) into deionized water, stirring, adding dicyandiamide, heating to 120-140°C, stirring, cooling, subjecting to reduced-pressure distillation, precipitating the filtrate with absolute ethanol, washing, suction filtering, purifying, drying, and grinding the precipitate to obtain a product for standby;

[0016] (4) Mixing soy protein isolate powder and the product obtained in step (3), and ball milling to obtain modified chitosan.

[0017] Wherein, in step (2), the mass ratio of chitosan hydrochloride to glutaraldehyde is 1:(0.2-0.5); in step (3), the mass ratio of chitosan hydrochloride microspheres to dicyandiamide is 1:(0.3-0.7); in step (4), the mass ratio of the product to soy protein isolate powder is 1:(0.4-0.7).

[0018] In some embodiments of the present invention, the hemostatic traditional Chinese medicine component is a composition of Clausena lansium leaves and carbonized human hair, and the mass ratio is 1:(0.3 - 0.7).

[0019] In some embodiments of the present invention, the preparation method of the modified xanthan gum comprises the following steps:

[0020] (1) Add polyethylene glycol 15 - hydroxystearate to an ethanol aqueous solution, stir and then spray it on the surface of xanthan gum, dry, sieve, and obtain product 1 for standby;

[0021] (2) Mix product 1 obtained in step (1) with maltodextrin, and perform steam granulation to obtain product 2 for standby;

[0022] (3) Add product 2 obtained in step (2) to deionized water, stir, adjust the pH to 8 - 10, add polypropylene glycol diglycidyl ether while stirring, heat to 45 - 60 °C, stir, precipitate, wash, and dry to obtain the modified xanthan gum.

[0023] In some embodiments of the present invention, in step (1), the mass ratio of xanthan gum to polyethylene glycol 15 - hydroxystearate is 1:(0.5 - 0.9).

[0024] Preferably, in step (1), the mass ratio of xanthan gum to polyethylene glycol 15 - hydroxystearate is 1:0.6.

[0025] In some embodiments of the present invention, in step (2), the mass ratio of product 1 to maltodextrin is 1:(0.1 - 0.4).

[0026] Preferably, in step (2), the mass ratio of product 1 to maltodextrin is 1:0.2.

[0027] In some embodiments of the present invention, in step (3), the mass ratio of product 2 to polypropylene glycol diglycidyl ether is 1:(0.05 - 0.3).

[0028] Preferably, in step (3), the mass ratio of product 2 to polypropylene glycol diglycidyl ether is 1:0.1.

[0029] During the storage process of the disinfectant, it will experience the temperatures of all four seasons. Especially in winter in the north, the low temperature can reach minus ten or even twenty - odd degrees, which may cause the freeze - thaw phenomenon of the disinfectant during the high - low temperature change, seriously affecting the use effect of the disinfectant. The thickener xanthan gum has excellent emulsifying and suspending ability, which can effectively help improve the stability of the disinfectant. However, untreated xanthan gum has problems with poor dispersibility and its high - temperature resistance also needs to be improved.

[0030] On the one hand, the applicant sprays an ethanol aqueous solution of polyethylene glycol 15 - hydroxystearate on the surface of xanthan gum. Further, by controlling the ratio, product 1 and maltodextrin are combined through steam granulation to obtain product 2. The non - ionic surfactant polyethylene glycol 15 - hydroxystearate can adsorb on the surface of xanthan gum particles, shielding some hydrophilic groups of xanthan gum, changing the interfacial structure of its colloidal particles, and enabling better dispersion of xanthan gum particles. Maltodextrin forms an interaction force through hydroxyl groups and carboxyl groups on the surface of xanthan gum, thereby increasing the specific gravity of xanthan gum particles, effectively avoiding the problem of xanthan gum agglomeration, improving the dispersibility of xanthan gum, and maltodextrin has good water solubility and does not affect the performance of xanthan gum itself, enabling xanthan gum to have good water solubility, emulsifying and suspending ability while improving its dispersibility. On the other hand, the applicant introduces polypropylene glycol diglycidyl ether to cross - link and modify product 2. Certain cross - link points can be generated between polypropylene glycol diglycidyl ether and xanthan gum, thereby enhancing the thermal stability of xanthan gum.

[0031] In some embodiments of the present invention, the emollient is glycerol or hyaluronic acid.

[0032] In some embodiments of the present invention, the preparation method of the dodecenyl succinic acid glucose ester comprises the following steps:

[0033] Mix anhydrous glucose and deionized water and add them to a reaction vessel. Under the condition of 30 - 40 °C, while stirring, add an aqueous sodium hydroxide solution to adjust the pH = 8 - 8.5, stir for 20 - 40 min, add dodecenyl succinic anhydride, stir under the condition of pH = 8 - 8.5, adjust the pH = 5.5 - 6.5, stir, and freeze - dry to obtain dodecenyl succinic acid glucose ester.

[0034] In some embodiments of the present invention, the molar ratio of anhydrous glucose to dodecenyl succinic anhydride is 1:(0.1 - 0.45).

[0035] Preferably, the molar ratio of anhydrous glucose to dodecenyl succinic anhydride is 1:0.3.

[0036] The applicant uses anhydrous glucose and dodecenyl succinic anhydride as raw materials and controls the ratio between them to synthesize dodecenyl succinic acid glucose ester. The dodecenyl succinic acid glucose ester molecule contains a hydroxyl hydrophilic group and a long carbon - chain hydrophobic group and thus has the characteristics of a surfactant. Moreover, the synthesized sugar ester has the properties of being easy to rinse and mild to the skin, enabling the skin disinfectant prepared in this application to have the advantage of mild performance. Further, the applicant compounded dodecenyl succinic acid glucose ester and fatty alcohol polyoxyethylene ether sulfate to obtain a composite surfactant, which plays a role in synergistically reducing viscosity and foam, and improving mildness and ease of rinsing.

[0037] On the other hand, the present invention also provides a preparation method of a skin disinfectant containing a disinfection and hemostasis composition as described in the above technical solution, including the following steps:

[0038] S1. Mix the composite surfactant and the emollient, and stir at 40 - 60 °C for 5 - 10 min to obtain a mixture A for standby.

[0039] S2. Mix the modified xanthan gum, absolute ethanol, and deionized water, and stir to obtain a mixture B for standby.

[0040] S3. Add the mixture B to the mixture A, stir, add the disinfection and hemostasis composition, and stir to obtain the skin disinfectant containing the disinfection and hemostasis composition.

[0041] Compared with the prior art, the present invention has the following beneficial effects:

[0042] (1) The present invention synthesizes a skin disinfectant containing a disinfection and hemostasis composition with absolute ethanol, a disinfection and hemostasis composition, modified xanthan gum, a composite surfactant, etc. as raw materials. Through the synergistic effect among the components, the skin disinfectant has the characteristics of good mildness, stability, and disinfection and hemostasis functions.

[0043] (2) The present invention uses xanthan gum as a raw material, sprays an ethanol aqueous solution of polyethylene glycol 15 - hydroxystearate on its surface, and further controls the ratio to combine maltodextrin through steam granulation, and finally introduces polypropylene glycol diglycidyl ether for cross - linking modification to obtain modified xanthan gum, improving the dispersibility and thermal stability of xanthan gum.

[0044] (3) The present invention uses anhydrous glucose and dodecenyl succinic anhydride as raw materials, controls the ratio of the two to synthesize glucose dodecenyl succinate, and then compound the glucose dodecenyl succinate and fatty alcohol polyoxyethylene ether sulfate to obtain a composite surfactant, which has the characteristics of mildness to the skin and easy rinsing.

[0045] (4) The skin disinfectant prepared by the present invention has good mildness, stability, and disinfection and hemostasis functions, and can be widely applied to the field of disinfectants, having good commercial application value. Specific Embodiments

[0046] The following will illustrate the present invention in combination with specific implementation examples. It should be noted that the following examples are examples of the present invention, only used to illustrate the present invention, and not used to limit the present invention. Other combinations and various improvements within the concept of the present invention can be made without departing from the main idea or scope of the present invention.

[0047] In the following examples and comparative examples, except for modified xanthan gum and dodecenyl succinate glucose ester, the other compound monomers and related reagents used can be purchased from the market. Among them, polyethylene glycol 15-hydroxystearate was purchased from Beijing Taize Jiaye Technology Development Co., Ltd.; maltodextrin was purchased from Xi'an Musen Bioengineering Co., Ltd.; polypropylene glycol diglycidyl ether was purchased from Hubei Xinyuhong Biomedicine Technology Co., Ltd.; chitosan was purchased from Shaanxi Rankang Biotechnology Co., Ltd.; liquid paraffin was purchased from Xinji Haorui Petrochemical Co., Ltd.; soy protein isolate powder was purchased from Shanghai Zhongfeng Biotechnology Co., Ltd.; fatty alcohol polyoxyethylene ether sulfate was purchased from Hunan Lichen Aowei Industrial Co., Ltd.

[0048] Preparation Example 1

[0049] The synthesis method of modified xanthan gum A comprises the following steps:

[0050] (1) Add 6 g of polyethylene glycol 15-hydroxystearate to 30 ml of 50 wt% ethanol aqueous solution, stir for 30 min, and then spray evenly on the surface of 10 g of xanthan gum, dry at 80° C. for 12 h, and pass through a 200 mesh sieve to obtain product 1 for later use;

[0051] (2) 10 g of the product 1 of step (1) and 2 g of maltodextrin were mixed, and steam granulated (inlet air temperature 70° C., atomization pressure 0.4 Ma, atomization speed 25 mL / min) to obtain product 2 for later use;

[0052] (3) Add 10 g of the product 2 of step (2) to 100 ml of deionized water, stir for 40 min, add 1 mol / L sodium hydroxide aqueous solution to adjust the pH to 9, add 1 g of polypropylene glycol diglycidyl ether while stirring, heat to 50° C., stir for 10 h, add 70 wt % ethanol aqueous solution to precipitate the solid, wash with anhydrous ethanol three times, and dry at 60° C. for 24 h to obtain modified xanthan gum A.

[0053] Preparation Example 2

[0054] The specific implementation method of modified xanthan gum B is the same as that of modified xanthan gum A, except that in step (1), the mass of polyethylene glycol 15-hydroxystearate is replaced with 4.5 g.

[0055] Preparation Example 3

[0056] The specific implementation method of modified xanthan gum C is the same as that of modified xanthan gum A, except that in step (2), the mass of maltodextrin is replaced with 0.7 g.

[0057] Preparation Example 4

[0058] Modified xanthan gum D, the specific implementation method is the same as that of modified xanthan gum A, the difference is that: in step (3), the mass of polypropylene glycol diglycidyl ether is replaced by 0.3 g.

[0059] Preparation Example 5

[0060] The synthesis method of dodecenyl succinic acid glucose ester A includes the following steps:

[0061] Mix 0.1 mol of anhydrous glucose and 20 ml of deionized water and add them to a reaction vessel. At 35 °C, while stirring, add 5 wt% sodium hydroxide aqueous solution until pH = 8, stir for 30 min, add 0.03 mol of dodecenyl succinic anhydride, stir for 3 h under the condition of pH = 8, add 5 wt% hydrochloric acid aqueous solution to adjust pH = 6, stir for 15 min, freeze-dry at -40 °C for 12 h to obtain dodecenyl succinic acid glucose ester A.

[0062] Preparation Example 6

[0063] Dodecenyl succinic acid glucose ester B, the specific implementation method is the same as that of dodecenyl succinic acid glucose ester A, the difference is that: the molar amount of dodecenyl succinic anhydride is replaced by 0.008 mol.

[0064] Preparation Example 7

[0065] The synthesis method of modified chitosan includes the following steps:

[0066] (1) Add 10 g of chitosan to 50 ml of 30 wt% hydrochloric acid aqueous solution, stir for 1 h, add 40 ml of absolute ethanol for precipitation, carry out vacuum filtration on the precipitate, wash it 3 times with deionized water, and dry it at 60 °C for 12 h to obtain chitosan hydrochloride for standby;

[0067] (2) Add 10 g of the chitosan hydrochloride obtained in step (1) to 40 ml of deionized water, stir for 30 min, then add it to 50 g of liquid paraffin, stir at 55 °C for 30 min, add 3 g of glutaraldehyde, stir for 3 h, wash it 3 times successively with petroleum ether and isopropanol, centrifuge, and vacuum dry at 60 °C for 12 h to obtain chitosan hydrochloride microspheres for standby;

[0068] (3) Add 10 g of the chitosan hydrochloride microspheres obtained in step (2) to 50 ml of deionized water, stir for 30 min, add 4 g of dicyandiamide, heat to 130 °C, stir for 4 h, cool to room temperature, carry out vacuum distillation, precipitate the filtrate with 40 ml of absolute ethanol, wash the precipitate with deionized water, filter it, purify it by Soxhlet extraction with acetone, dry it at 60 °C for 12 h, and grind it to obtain the product for standby;

[0069] (4) Mix 5 g of soy protein isolate powder and 10 g of the product from step (3), and ball mill to obtain modified chitosan.

[0070] Preparation Example 8

[0071] The preparation method of the disinfection and hemostasis composition comprises the following steps:

[0072] Mix 40 g of the compound antibacterial disinfectant, 3 g of hydrogenated castor oil, 2 g of Codonopsis pilosula, and 5 g of the hemostatic traditional Chinese medicine components, stir for 15 min, and grind for 7 min to obtain the disinfection and hemostasis composition.

[0073] Among them, the compound antibacterial disinfectant is a mixture of triclosan and modified chitosan, with a mass ratio of 1:2; the hemostatic traditional Chinese medicine components are a composition of Clausena lansium leaves and human hair carbon, with a mass ratio of 1:0.5.

[0074] Example 1

[0075] A skin disinfectant containing the disinfection and hemostasis composition, by weight, the skin disinfectant comprises the following raw materials: 70 parts of absolute ethanol, 20 parts of the disinfection and hemostasis composition, 2 parts of modified xanthan gum A, 4 parts of glycerol, 15 parts of a compound surfactant, and 25 parts of deionized water. Among them, the compound surfactant is a mixture of dodecenyl succinic acid glucose ester A and fatty alcohol polyoxyethylene ether sulfate, with a mass ratio of 1:0.6.

[0076] In this embodiment, the preparation method of the skin disinfectant containing the disinfection and hemostasis composition comprises the following steps:

[0077] S1. Mix the compound surfactant and glycerol, and stir at 50 °C for 7 min to obtain mixture A for standby;

[0078] S2. Mix modified xanthan gum A, absolute ethanol, and deionized water, and stir for 30 min to obtain mixture B for standby;

[0079] S3. Add mixture B to mixture A, stir for 20 min, add the disinfection and hemostasis composition, and stir for 30 min to obtain the skin disinfectant containing the disinfection and hemostasis composition.

[0080] Example 2

[0081] A skin disinfectant containing the disinfection and hemostasis composition, by weight, the skin disinfectant comprises the following raw materials: 60 parts of absolute ethanol, 15 parts of the disinfection and hemostasis composition, 2 parts of modified xanthan gum A, 2 parts of hyaluronic acid, 10 parts of a compound surfactant, and 20 parts of deionized water. Among them, the compound surfactant is a mixture of dodecenyl succinic acid glucose ester A and fatty alcohol polyoxyethylene ether sulfate, with a mass ratio of 1:0.5.

[0082] In this embodiment, the preparation method of the skin disinfectant containing the disinfection and hemostasis composition comprises the following steps:

[0083] S1. Mix the composite surfactant and hyaluronic acid, and stir at 40 °C for 10 min to obtain a mixture A for standby;

[0084] S2. Mix the modified xanthan gum A, absolute ethanol and deionized water, and stir for 30 min to obtain a mixture B for standby;

[0085] S3. Add the mixture B to the mixture A, stir for 20 min, add the disinfection and hemostasis composition, and stir for 30 min to obtain the skin disinfectant containing the disinfection and hemostasis composition.

[0086] Example 3

[0087] A skin disinfectant containing a disinfection and hemostasis composition, by weight, the skin disinfectant comprises the following raw materials: 80 parts of absolute ethanol, 25 parts of the disinfection and hemostasis composition, 2 parts of modified xanthan gum A, 6 parts of glycerol, 20 parts of the composite surfactant, 30 parts of deionized water, wherein the composite surfactant is a mixture of dodecenyl succinic acid glucose ester A and fatty alcohol polyoxyethylene ether sulfate, and the mass ratio is 1:0.8.

[0088] In this embodiment, the preparation method of the skin disinfectant containing the disinfection and hemostasis composition comprises the following steps:

[0089] S1. Mix the composite surfactant and glycerol, and stir at 60 °C for 5 min to obtain a mixture A for standby;

[0090] S2. Mix the modified xanthan gum A, absolute ethanol and deionized water, and stir for 30 min to obtain a mixture B for standby;

[0091] S3. Add the mixture B to the mixture A, stir for 20 min, add the disinfection and hemostasis composition, and stir for 30 min to obtain the skin disinfectant containing the disinfection and hemostasis composition.

[0092] Example 4

[0093] A skin disinfectant containing a disinfection and hemostasis composition, by weight, the skin disinfectant comprises the following raw materials: 65 parts of absolute ethanol, 17 parts of the disinfection and hemostasis composition, 0.5 part of modified xanthan gum A, 3 parts of glycerol, 15 parts of the composite surfactant, 22 parts of deionized water, wherein the composite surfactant is a mixture of dodecenyl succinic acid glucose ester A and fatty alcohol polyoxyethylene ether sulfate, and the mass ratio is 1:0.6.

[0094] In this embodiment, the preparation method of the skin disinfectant containing the disinfection and hemostasis composition is the same as that in Embodiment 1.

[0095] Example 5

[0096] A skin disinfectant containing a disinfection and hemostasis composition. By weight, the skin disinfectant comprises the following raw materials: 75 parts of absolute ethanol, 22 parts of the disinfection and hemostasis composition, 3 parts of modified xanthan gum A, 5 parts of hyaluronic acid, 15 parts of a composite surfactant, and 27 parts of deionized water. Among them, the composite surfactant is a mixture of dodecenyl succinic acid glucose ester A and fatty alcohol polyoxyethylene ether sulfate, and the mass ratio is 1:0.6.

[0097] In this example, the preparation method of the skin disinfectant containing the disinfection and hemostasis composition is the same as that in Example 1.

[0098] Example 6

[0099] This example provides a skin disinfectant containing a disinfection and hemostasis composition and its preparation method. The specific implementation manner is the same as that in Example 1, except that modified xanthan gum B is used to replace modified xanthan gum A in equal amount.

[0100] Example 7

[0101] This example provides a skin disinfectant containing a disinfection and hemostasis composition and its preparation method. The specific implementation manner is the same as that in Example 1, except that modified xanthan gum C is used to replace modified xanthan gum A in equal amount.

[0102] Example 8

[0103] This example provides a skin disinfectant containing a disinfection and hemostasis composition and its preparation method. The specific implementation manner is the same as that in Example 1, except that modified xanthan gum D is used to replace modified xanthan gum A in equal amount.

[0104] Example 9

[0105] This example provides a skin disinfectant containing a disinfection and hemostasis composition and its preparation method. The specific implementation manner is the same as that in Example 1, except that dodecenyl succinic acid glucose ester B is used to replace dodecenyl succinic acid glucose ester A in equal amount.

[0106] Comparative Example 1

[0107] This comparative example provides a skin disinfectant containing a disinfection and hemostasis composition and its preparation method. The specific implementation manner is the same as that in Example 1, except that xanthan gum is used to replace modified xanthan gum A in equal amount.

[0108] Comparative Example 2

[0109] This comparative example provides a skin disinfectant containing a disinfection and hemostasis composition and its preparation method. The specific implementation manner is the same as that of Example 1, except that dodecenyl succinic acid glucose ester A is used to replace the composite surfactant in equal amounts.

[0110] Comparative Example 3

[0111] This comparative example provides a skin disinfectant containing a disinfection and hemostasis composition and its preparation method. The specific implementation manner is the same as that of Example 1, except that fatty alcohol polyoxyethylene ether sulfate is used to replace the composite surfactant in equal amounts.

[0112] Performance Test

[0113] The mildness and stability of the skin disinfectants of the above Examples 1-9 and Comparative Examples 1-3 were tested, and the test results are shown in Table 1.

[0114] (1) Mildness

[0115] The irritation of the skin disinfectants prepared in Examples 1-9 and Comparative Examples 1-3 to the skin was tested according to the "Disinfection Technical Specification".

[0116] (2) Stability

[0117] The skin disinfectants prepared in Examples 1-9 and Comparative Examples 1-3 were placed at 25°C for 10 days, then placed at -5°C for 24 hours, and then placed at 40°C for 24 hours, and then restored to room temperature to observe whether there were phenomena of stratification and precipitation, abnormal smell and color change.

[0118] Table 1

[0119]

[0120]

[0121] As can be seen from the data in Table 1, the skin disinfectant containing the disinfection and hemostasis composition in Examples 1-5 of the present invention as a whole has good mildness and stability. Among them, in Examples 6-8, the proportion of key components in the synthesis process of modified xanthan gum was changed, resulting in poor improvement of the dispersibility and thermal stability of modified xanthan gum, and further leading to a decrease in the stability of the skin disinfectant, but having no effect on mildness; in Example 9, the proportion between anhydrous glucose and dodecenyl succinic anhydride in the synthesis process of dodecenyl succinic acid glucoside was changed, resulting in by-products in the synthesis process of dodecenyl succinic acid glucoside, and further leading to a decrease in the mildness of the skin disinfectant, but having little effect on stability; in Comparative Example 1 and Comparative Examples 2-3, xanthan gum was used to equally replace modified xanthan gum A, and dodecenyl succinic acid glucoside A and fatty alcohol polyoxyethylene ether sulfate were used to equally replace the composite surfactant respectively. It was found through testing that the stability of the skin disinfectant in Comparative Example 1 showed poor results while having little effect on mildness, and the mildness of the skin disinfectant in Comparative Examples 1-2 showed poor results while having little effect on stability.

[0122] The bactericidal, disinfection and hemostasis properties of the skin disinfectants in Examples 1-5 above were tested, and the test results are shown in Table 2.

[0123] (1) Bactericidal and disinfection properties

[0124] Taking Escherichia coli as an example, the antibacterial rate of the skin disinfectant was tested. One loop of the slant culture of Escherichia coli was inoculated into the broth medium. After culturing at 37°C for 24 hours, 0.2 ml was taken from each and inoculated into 3 plate media. An equal amount of 1 ml of the skin disinfectant prepared in the above examples was respectively dropped into the 3 plate media; after acting for 3 minutes, the average antibacterial rate was detected, and the remaining operations all conformed to the "Disinfection Technical Specification".

[0125] (2) Hemostasis properties

[0126] Twelve healthy clean-grade New Zealand rabbits, half male and half female, with a body weight of 220±20 g, were evenly divided into 4 groups. After being anesthetized by intravenous injection of 2 wt% pentobarbital sodium at 35 mg / kg through the marginal ear vein and disinfected with 75 wt% medical alcohol, each group was scratched, and the wound depth and length were the same (depth 1 mm, length 1 cm). After allowing free bleeding for 5 s, the wound was disinfected with 75 wt% medical alcohol, and then the same amount of 2 g of the skin disinfectant prepared in the example was applied to the scratched part, and the wound hemostasis time of each group was observed, that is, the time from when the skin disinfectant was applied until the bleeding stopped.

[0127] Table 2

[0128]

[0129]

[0130] As can be seen from the data in Table 2, the skin disinfectants in Examples 1-5 of the present invention all have good bactericidal and hemostatic properties overall.

[0131] The above embodiments are only for illustrating the technical concept and characteristics of the present invention, and the purpose is to enable those who are familiar with this technology to understand the content of the present invention and implement it. However, the protection scope of the present invention cannot be limited thereby. Any equivalent changes or modifications made according to the spirit and essence of the present invention should be covered within the protection scope of the present invention.

Claims

1. A skin disinfectant containing a disinfecting and hemostatic composition, characterized in that: The skin disinfectant comprises the following raw materials by weight: 60-80 parts of anhydrous ethanol, 15-25 parts of a disinfecting hemostatic composition, 0.5-3 parts of modified xanthan gum, 2-6 parts of a softener, 10-20 parts of a composite surfactant, and 20-30 parts of deionized water, wherein the composite surfactant is a mixture of dodecenyl succinate glucose ester and fatty alcohol polyoxyethylene ether sulfate.

2. The skin disinfectant containing the disinfectant and hemostatic composition according to claim 1, characterized in that: Each portion of the disinfection and hemostasis composition comprises the following raw materials by weight: 30-50 parts of composite antibacterial disinfectant, 1-5 parts of hydrogenated castor oil, 1-3 parts of Codonopsis pilosula, and 2-8 parts of hemostatic Chinese medicine ingredients.

3. The skin disinfectant containing the disinfectant and hemostatic composition according to claim 1, characterized in that: The preparation method of the modified xanthan gum comprises the following steps: (1) adding polyethylene glycol 15-hydroxystearate to an ethanol aqueous solution, stirring and spraying the mixture on the surface of xanthan gum, drying and sieving to obtain product 1 for later use; (2) mixing the product 1 of step (1) with maltodextrin, and steam granulating the mixture to obtain a product 2 for later use; (3) Add the product 2 of step (2) into deionized water, stir, adjust the pH to 8-10, add polypropylene glycol diglycidyl ether while stirring, heat to 45-60° C., stir, precipitate, wash, and dry to obtain modified xanthan gum.

4. The skin disinfectant containing the disinfectant and hemostatic composition according to claim 3, characterized in that: In the step (1), the mass ratio of xanthan gum to polyethylene glycol 15-hydroxystearate is 1:(0.5-0.9).

5. The skin disinfectant containing the disinfectant and hemostatic composition according to claim 3, characterized in that: In the step (2), the mass ratio of product 1 to maltodextrin is 1:(0.1-0.4).

6. The skin disinfectant containing the disinfectant and hemostatic composition according to claim 3, characterized in that: In the step (3), the mass ratio of the product 2 to polypropylene glycol diglycidyl ether is 1:(0.05-0.3).

7. The skin disinfectant containing the disinfectant and hemostatic composition according to claim 1, characterized in that: The emollient is glycerin or hyaluronic acid.

8. The skin disinfectant containing the disinfectant and hemostatic composition according to claim 1, characterized in that: The preparation method of the dodecenyl succinate glucose ester comprises the following steps: Anhydrous glucose and deionized water are mixed and added to a reaction container. Under the condition of 30-40° C., sodium hydroxide aqueous solution is added while stirring to adjust the pH value to 8-8.

5. The mixture is stirred for 20-40 minutes. Dodecenyl succinic anhydride is added and stirred under the condition of pH value to 8-8.

5. The pH value is adjusted to 5.5-6.

5. The mixture is stirred and freeze-dried to obtain dodecenyl succinic acid glucose ester.

9. The skin disinfectant containing the disinfectant and hemostatic composition according to claim 8, characterized in that: The molar ratio of the anhydrous glucose to dodecenylsuccinic anhydride is 1:(0.1-0.45).

10. A method for preparing a skin disinfectant containing a disinfectant and hemostatic composition according to any one of claims 1 to 9, characterized in that: The following steps are involved: S1. Mix the composite surfactant and the emollient, and stir at 40-60° C. for 5-10 min to obtain a mixture A for later use; S2, mixing the modified xanthan gum, anhydrous ethanol and deionized water, stirring to obtain a mixture B for later use; S3. Add mixture B into mixture A, stir, add the disinfectant hemostatic composition, stir, and obtain a skin disinfectant containing the disinfectant hemostatic composition.

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