Tobacco alkaloid embedding material as well as preparation method and application thereof

Abstract

The invention provides a tobacco alkaloid embedding material as well as a preparation method and application thereof. The tobacco alkaloid embedding material comprises the following components: a filling agent, tobacco alkaloid or salt thereof, a binding agent and a dispersing agent, the binder comprises a combination of at least two of pectin, konjac glucomannan, beta-cyclodextrin, xanthan gum, Arabic gum, guar gum, carrageenan or sodium alginate; the dispersing agent comprises a combination of at least two of calcium hydrophosphate, stearamide, glyceryl distearate, lecithin, magnesium stearate or calcium chloride. The tobacco alkaloid embedding material provided by the invention is safe in component, long-term uniform slow release of the tobacco alkaloid or the salt thereof in the oral cavity is realized through the synergistic effect of the binder and the dispersing agent, long-term and mild physiological satisfaction is provided for consumers, and the preparation method is simple to operate and suitable for large-scale production.

Description

Technical Field

[0001] The present invention belongs to the technical field of tobacco alkaloid products, and particularly relates to a tobacco alkaloid embedding material, a preparation method thereof, and an application thereof. Background Art

[0002] Existing oral tobacco is usually placed between the upper lip and the gum and gradually releases through the cellulose in the bag. However, consumers need to tightly close their lips, which is inconvenient for speaking on the one hand and affects aesthetics on the other hand. If the oral tobacco is directly placed in the mouth, a large amount of saliva penetrates into the inside of the bag, causing the tobacco alkaloids to be rapidly extracted, and the amount of tobacco alkaloids instantaneously absorbed by the human body is too large, resulting in adverse symptoms such as dizziness and vomiting.

[0003] CN119185163A discloses a nicotine bag for transoral mucosal absorption and a preparation method thereof. The nicotine bag includes nicotine particles, at least one liquid-containing bursting bead, and a non-woven fabric bag. The nicotine particles and the bursting beads are encapsulated in the non-woven fabric bag. The number of bursting beads contained in each non-woven fabric bag is 1 to 3. When the nicotine particles are dry particles, the particle size is 1 - 1000 microns, and the moisture content ranges from 1% - 10% (W / W). When they are wet particles, the particle size is 1 - 1000 microns, and the moisture content ranges from 5% - 15% (W / W). When they are oily particles, the particle size is 1 - 1000 microns, and the moisture content ranges from 1% - 10% (W / W). When they are pellet particles, the particle size is 30 - 2500 microns, and the moisture content ranges from 1% - 10% (W / W). Its composition is complex and the release rate is too fast.

[0004] CN116419682A discloses a bag composition, which contains a nicotine-ion exchange resin combination and an inorganic divalent cation, but still has a relatively fast nicotine release.

[0005] Therefore, it is necessary to develop a tobacco alkaloid embedding material to achieve long-term and slow release of tobacco alkaloids in the mouth. Summary of the Invention

[0006] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide a tobacco alkaloid embedding material, a preparation method thereof, and an application thereof. The tobacco alkaloid embedding material provided by the present invention has safe components. Through the synergistic effect of the binder and the dispersant, long-term and uniform slow release of tobacco alkaloids or their salts in the mouth is achieved, providing consumers with a long-lasting and gentle physiological satisfaction. The preparation method is simple to operate and suitable for large-scale production.

[0007] To achieve the purpose of this invention, the present invention adopts the following technical solutions:

[0008] In the first aspect, the present invention provides a tobacco alkaloid embedding material, and the components of the tobacco alkaloid embedding material include a filler, a tobacco alkaloid or its salt, a binder, and a dispersant;

[0009] The binder includes a combination of at least two of pectin, konjac gum, β-cyclodextrin, xanthan gum, arabic gum, guar gum, carrageenan or sodium alginate; the dispersant includes a combination of at least two of calcium hydrogen phosphate, stearamide, glycerol distearate, lecithin, magnesium stearate or calcium chloride.

[0010] The tobacco alkaloid embedding composition provided by the present invention has safe components. Through the synergistic effect of the binder and the dispersant, the long-term and uniform slow release of tobacco alkaloids or their salts in the oral cavity is realized, and it has a better sensory evaluation effect, providing consumers with a long-lasting and mild physiological satisfaction.

[0011] Preferably, the components of the tobacco alkaloid embedding composition include 30-50 parts by weight of a filler, 1-20 parts by weight of a tobacco alkaloid or its salt, 20-30 parts by weight of a binder, and 1-5 parts by weight of a dispersant.

[0012] The weight parts of the filler can be 30 parts, 32 parts, 34 parts, 36 parts, 38 parts, 40 parts, 42 parts, 44 parts, 46 parts, 48 parts or 50 parts, etc.

[0013] The weight parts of the tobacco alkaloid or its salt can be 1 part, 3 parts, 5 parts, 8 parts, 10 parts, 13 parts, 15 parts, 18 parts or 20 parts, etc.

[0014] The weight parts of the binder can be 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30 parts, etc.

[0015] The weight parts of the dispersant can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5 parts, etc.

[0016] Other specific point values within the above numerical ranges can be selected and will not be elaborated one by one here.

[0017] When the components in the present invention are within the above proportional ranges, the long-term slow release effect of the tobacco alkaloid or its salt in the oral cavity is better.

[0018] Preferably, the tobacco alkaloid includes any one or a combination of at least two of nicotine, nornicotine, anatabine or anabaseine; the tobacco alkaloid salt includes any one or a combination of at least two of the citrate, malate, tartrate, salicylate or hydrochloride of the tobacco alkaloid.

[0019] The tobacco alkaloid salts are less irritating than tobacco alkaloids. The present invention can achieve the long-acting sustained release of tobacco alkaloids or their salts commonly used in the art. The type of tobacco alkaloids or their salts has no effect on the sustained release effect. The tobacco alkaloid salts include tobacco alkaloid salts formed by the reaction of acids commonly used in the art and tobacco alkaloids.

[0020] The nicotine in the present invention can be prepared by a common method in the art, and the obtained tobacco alkaloid primary extract contains 90-95% nicotine and 5-10% nornicotine, anatabine and anabasine. The primary extract is further purified to obtain purified nicotine. The embedded material of the present invention can coat various types of tobacco alkaloids (any one of nicotine, nornicotine, anatabine or anabasine or a combination of at least two), and the type of tobacco alkaloid does not affect the sustained-release effect.

[0021] Preferably, the binder comprises pectin, konjac gum and β-cyclodextrin.

[0022] The pectin, konjac gum and beta-cyclodextrin in the binder of the present invention have a synergistic effect, and the three can work together to form a better embedding network structure, further promoting the long-term uniform sustained release of tobacco alkaloids or salts thereof in the oral cavity.

[0023] Preferably, the dispersant comprises calcium hydrogen phosphate, stearamide and glyceryl distearate.

[0024] The calcium hydrogen phosphate, stearamide and distearic acid glyceryl in the dispersant of the present invention have a synergistic dispersion and synergistic effect, and the three can synergistically form a better embedding network structure, further promoting the long-term uniform sustained release of tobacco alkaloids or salts thereof in the oral cavity.

[0025] Preferably, the filler comprises any one of bean dregs, coffee dregs, tea dregs, fruit peel dregs or wine dregs, or a combination of at least two of them.

[0026] The present invention uses food residues (safe and edible) as fillers, realizes waste utilization, turns waste into treasure, and saves production components. The types of fillers include but are not limited to bean dregs, coffee residues, tea residues, fruit peel residues or wine lees. The bean dregs are the residues filtered after preparing soybean milk, the tea residues are the residues after brewing tea leaves, the coffee residues are the residues after grinding and brewing coffee beans, and the wine lees are the residues after brewing wine. The present invention can prepare tobacco alkaloid embedded materials with different natural flavors according to the properties of the food residues.

[0027] Preferably, the tobacco alkaloid embedding material further comprises 10-20 parts of flavoring agent by weight.

[0028] The weight proportions of the flavoring agent may be 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts or 20 parts, etc.

[0029] Other specific point values within the above numerical ranges can be selected and will not be elaborated one by one here.

[0030] Preferably, the flavoring agent includes any one or a combination of at least two of edible salt, maltose, fructose, glucose, sucrose, sucralose, saccharin, aspartame, sodium cyclamate or acesulfame potassium.

[0031] The present invention can add flavoring agents common in the art to prepare tobacco alkaloid inclusion complexes with unique flavors according to personal preferences.

[0032] Preferably, the components of the tobacco alkaloid inclusion complex further include 1-10 parts by weight of edible oil.

[0033] The parts by weight of the edible oil can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts, etc.

[0034] Other specific point values within the above numerical ranges can be selected and will not be elaborated one by one here.

[0035] Preferably, the edible oil includes any one or a combination of at least two of butter, soybean oil, corn oil, peanut oil, olive oil, rapeseed oil, sunflower seed oil or sesame oil.

[0036] In a second aspect, the present invention provides a preparation method of a tobacco alkaloid inclusion complex as described in the first aspect, and the preparation method includes:

[0037] (1) Mix the filler and the tobacco alkaloid or its salt with water, let it stand, and obtain a mixture;

[0038] (2) Mix the mixture obtained in step (1) with a binder and a dispersant with water, granulate, and dry to obtain the tobacco alkaloid inclusion complex.

[0039] The preparation method of the tobacco alkaloid inclusion complex provided by the present invention is simple to operate and suitable for large-scale production.

[0040] Preferably, in step (1), the preparation process of the tobacco alkaloid salt includes: mixing the tobacco alkaloid with an acidity regulator, and adjusting the pH value to 5-6 to obtain the tobacco alkaloid salt.

[0041] The specific point values in 5-6 can be 5, 5.1, 5.2, 5.3, 5.4, 5.5, 5.6, 5.7, 5.8, 5.9 or 6, etc.

[0042] Preferably, the acidity regulator includes any one or a combination of at least two of aqueous citric acid solution, aqueous malic acid solution, aqueous tartaric acid solution, aqueous salicylic acid solution or aqueous hydrochloric acid solution.

[0043] Preferably, in step (1), the mixing method is stirring.

[0044] Preferably, the mixing time is 10 - 30 min, for example, it can be 10 min, 12 min, 14 min, 16 min, 18 min, 20 min, 22 min, 24 min, 26 min, 28 min or 30 min, etc.

[0045] Preferably, the static temperature is 40 - 50 °C, for example, it can be 40 °C, 41 °C, 42 °C, 43 °C, 44 °C, 45 °C, 46 °C, 47 °C, 48 °C, 49 °C or 50 °C, etc.; the static time is 2 - 4 h, for example, it can be 2 h, 2.2 h, 2.4 h, 2.6 h, 2.8 h, 3 h, 3.2 h, 3.4 h, 3.6 h, 3.8 h or 4 h, etc.

[0046] Other specific point values within the above numerical ranges can be selected and will not be elaborated one by one here.

[0047] Preferably, after static, it further includes the steps of freeze - drying and grinding into powder.

[0048] Preferably, in step (2), the mixing method is stirring.

[0049] Preferably, during the mixing process, flavoring agents and edible oil are also added.

[0050] Preferably, the drying method is drying in an oven.

[0051] Preferably, the drying temperature is 40 - 60 °C, for example, it can be 40 °C, 42 °C, 44 °C, 46 °C, 48 °C, 50 °C, 52 °C, 54 °C, 56 °C, 58 °C or 60 °C, etc.; the drying time is 1 - 3 h, for example, it can be 1 h, 1.2 h, 1.4 h, 1.6 h, 1.8 h, 2 h, 2.2 h, 2.4 h, 2.6 h, 2.8 h or 3 h, etc.

[0052] Other specific point values within the above numerical ranges can be selected and will not be elaborated one by one here.

[0053] In the third aspect, the present invention provides an application of the tobacco alkaloid inclusion complex as described in the first aspect in the preparation of oral tobacco.

[0054] The tobacco alkaloid inclusion complex provided by the present invention can be directly encapsulated in a non - woven fabric bag and used as oral tobacco.

[0055] Compared with the prior art, the present invention has the following beneficial effects:

[0056] The tobacco alkaloid embedding composition provided by the present invention is safe in composition. Through the synergistic effect of the binder and the dispersant, a suitable embedding network structure is constructed to achieve the long-term uniform slow release of tobacco alkaloids or their salts in the oral cavity, with a better sensory smoking evaluation effect, providing consumers with a long-lasting and gentle physiological satisfaction. The preparation method is simple in operation and suitable for large-scale production. Detailed Embodiments

[0057] To further illustrate the technical means and effects adopted by the present invention, the following further describes the technical solution of the present invention in combination with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0058] For those not specifying specific techniques or conditions in the embodiments, they shall be carried out according to the techniques or conditions described in the literature in this field or according to the product specifications. For the reagents or instruments not indicating the manufacturer, they are all conventional products that can be obtained through regular channels of commercial purchase.

[0059] The sources of the materials used in the following detailed embodiments are as follows:

[0060] Raw material name Purchasing manufacturer Model Pectin Sinopharm Chemical Reagent Co., Ltd. CAS No.: 9000-65-5 Konjac gum Sinopharm Chemical Reagent Co., Ltd. CAS No.: 37220-17-0 β-Cyclodextrin Sinopharm Chemical Reagent Co., Ltd. CAS No.: 7585-39-9

[0061] Preparation Example 1

[0062] This preparation example provides a nicotine, and its preparation method includes the following steps: extracting nicotine from tobacco by ultrasonic-assisted extraction method, specifically weighing 500 g of tobacco powder, adding 12.5 L of 0.5% sodium hydroxide solution, placing it in an ultrasonic cleaning device for extraction for 1 h, filtering out the extract, extracting the filtered extract, and performing vacuum distillation to remove the solvent after extraction to obtain the nicotine.

[0063] Example 1

[0064] This example provides a tobacco alkaloid embedding composition, which includes the following components in parts by weight:

[0065]

[0066] Its preparation method is as follows:

[0067] (1) Mix nicotine with a citric acid aqueous solution, adjust the pH value to 5.5 to obtain nicotine salt; add the filler and nicotine salt to water and stir for 20 min, let it stand at 45 °C for 3 h, freeze-dry and grind into powder to obtain a mixture;

[0068] (2) Add water to stir the mixture obtained in step (1) with the binder, dispersant, flavoring agent and edible oil, granulate, and dry at 50 °C for 2 h to obtain the tobacco alkaloid embedding composition.

[0069] Example 2

[0070] This embodiment provides a tobacco alkaloid inclusion complex, which comprises the following components by weight:

[0071]

[0072] The preparation method thereof is as follows:

[0073] (1) Mix nicotine with an aqueous solution of malic acid, adjust the pH value to 5 to obtain nicotine salt; stir the filler and nicotine salt with water for 10 min, let stand at 40 °C for 4 h, freeze-dry and grind into powder to obtain a mixture;

[0074] (2) Stir the mixture obtained in step (1) with a binder, a dispersant, a flavoring agent and edible oil with water, granulate, and dry at 40 °C for 3 h to obtain the tobacco alkaloid inclusion complex.

[0075] Example 3

[0076] This embodiment provides a tobacco alkaloid inclusion complex, which comprises the following components by weight:

[0077]

[0078]

[0079] The preparation method thereof is as follows:

[0080] (1) Mix nicotine with an aqueous solution of tartaric acid, adjust the pH value to 6 to obtain nicotine salt; stir the filler and nicotine salt with water for 30 min, let stand at 50 °C for 2 h, freeze-dry and grind into powder to obtain a mixture;

[0081] (2) Stir the mixture obtained in step (1) with a binder, a dispersant, a flavoring agent and edible oil with water, granulate, and dry at 60 °C for 1 h to obtain the tobacco alkaloid inclusion complex.

[0082] Example 4

[0083] This embodiment provides a tobacco alkaloid inclusion complex, which is only different from Example 1 in that: "8 parts of pectin, 10 parts of konjac gum and 7 parts of β-cyclodextrin" in the binder is replaced with "8 parts of xanthan gum, 10 parts of arabic gum and 7 parts of guar gum", and other raw materials and steps remain unchanged.

[0084] Example 5

[0085] This embodiment provides a tobacco alkaloid inclusion complex, which is only different from Example 1 in that: "2 parts of calcium hydrogen phosphate, 1 part of stearamide and 1 part of glycerol distearate" in the dispersant is replaced with "2 parts of lecithin, 1 part of magnesium stearate and 1 part of calcium chloride", and other raw materials and steps remain unchanged.

[0086] Example 6

[0087] This example provides a tobacco alkaloid inclusion complex. The difference from Example 1 is only that pectin is not added, and its reduced amount is proportionally distributed to the other two components of the binder, while other raw materials and steps remain unchanged.

[0088] Example 7

[0089] This example provides a tobacco alkaloid inclusion complex. The difference from Example 1 is only that konjac glucomannan is not added, and its reduced amount is proportionally distributed to the other two components of the binder, while other raw materials and steps remain unchanged.

[0090] Example 8

[0091] This example provides a tobacco alkaloid inclusion complex. The difference from Example 1 is only that β-cyclodextrin is not added, and its reduced amount is proportionally distributed to the other two components of the binder, while other raw materials and steps remain unchanged.

[0092] Example 9

[0093] This example provides a tobacco alkaloid inclusion complex. The difference from Example 1 is only that calcium hydrogen phosphate is not added, and its reduced amount is proportionally distributed to the other two components of the dispersant, while other raw materials and steps remain unchanged.

[0094] Example 10

[0095] This example provides a tobacco alkaloid inclusion complex. The difference from Example 1 is only that stearamide is not added, and its reduced amount is proportionally distributed to the other two components of the dispersant, while other raw materials and steps remain unchanged.

[0096] Example 11

[0097] This example provides a tobacco alkaloid inclusion complex. The difference from Example 1 is only that glyceryl distearate is not added, and its reduced amount is proportionally distributed to the other two components of the dispersant, while other raw materials and steps remain unchanged.

[0098] Comparative Example 1

[0099] This comparative example provides a tobacco alkaloid inclusion complex. The difference from Example 1 is only that the binder is not added, and its reduced amount is proportionally distributed to the components of the dispersant, while other raw materials and steps remain unchanged.

[0100] Comparative Example 2

[0101] This comparative example provides a tobacco alkaloid inclusion complex, and the difference from Example 1 is only that: no dispersant is added, and the reduced amount is proportionally distributed to each component of the binder, and other raw materials and steps remain unchanged.

[0102] Comparative Example 3

[0103] This comparative example provides a tobacco alkaloid inclusion complex, and the difference from Example 1 is only that: in the binder, "8 parts of pectin, 10 parts of konjac gum and 7 parts of β-cyclodextrin" are replaced with "5 parts of pectin, 5 parts of konjac gum and 5 parts of β-cyclodextrin", and in the dispersant, "2 parts of calcium hydrogen phosphate, 1 part of stearamide and 1 part of glycerol distearate" are replaced with "3 parts of calcium hydrogen phosphate, 3 parts of stearamide and 2 parts of glycerol distearate", and other raw materials and steps remain unchanged.

[0104] Comparative Example 4

[0105] This comparative example provides a tobacco alkaloid inclusion complex, and the difference from Example 1 is only that: in the binder, "8 parts of pectin, 10 parts of konjac gum and 7 parts of β-cyclodextrin" are replaced with "12 parts of pectin, 13 parts of konjac gum and 10 parts of β-cyclodextrin", and in the dispersant, "2 parts of calcium hydrogen phosphate, 1 part of stearamide and 1 part of glycerol distearate" are replaced with "0.2 parts of calcium hydrogen phosphate, 0.1 part of stearamide and 0.2 parts of glycerol distearate", and other raw materials and steps remain unchanged.

[0106] Comparative Example 5

[0107] This comparative example provides a commercially available nicotine lozenge.

[0108] Test Example 1

[0109] (1) Test samples: Tobacco alkaloid inclusion complexes prepared in Examples 1-11 and Comparative Examples 1-4, and the commercially available nicotine lozenge provided in Comparative Example 5;

[0110] (2) Test method: First, prepare a simulated oral solution (phosphate buffer solution with a pH of 7.4), and set the temperature to 37°C; put the tobacco alkaloid inclusion complex into a reaction tube containing the simulated oral solution, and shake the reaction tube once every 1 minute, and test the tobacco alkaloid content at 0 min, 5 min, 10 min, 30 min, 60 min, and 90 min. The tobacco alkaloid content is tested by the standard HPLC method, and 3 samples are tested at each time point as parallel experiments;

[0111] (3) Test results: As shown in Table 1, the tobacco alkaloid inclusion complex provided by the present invention has safe components and has a better sustained-release effect compared with commercially available products. The binder and the dispersant cooperate with each other, and at a specific ratio, a good embedding structure is constructed to achieve the long-term and uniform sustained release of tobacco alkaloids in the oral cavity. Pectin, konjac gum and β-cyclodextrin in the binder have a synergistic effect, and the embedding network constructed by them is more suitable for the long-term sustained release of tobacco alkaloids compared with other binders. Calcium hydrogen phosphate, stearamide and glycerol distearate in the dispersant have a synergistic effect, and the embedding network constructed by them is more suitable for the long-term sustained release of tobacco alkaloids compared with other dispersants.

[0112] Table 1

[0113]

[0114] Test Example 2

[0115] (1) Test samples: The tobacco alkaloid inclusion complexes prepared in Examples 1-11 and Comparative Examples 1-4, and the commercially available nicotine oral tobacco provided in Comparative Example 5.

[0116] (2) Test method: Organize relevant smoking evaluation experts. The smoking evaluators should be sober-minded and have highly sensitive senses. Before smoking evaluation, they should avoid drinking alcohol or eating strongly stimulating foods. The smoking evaluation environment should be quiet, with appropriate temperature and humidity, the temperature is 18-25 °C, and the relative humidity is 55-70%. It should have good ventilation conditions. The smoking evaluators place the samples in their mouths and score the sensory smoking evaluation according to the scoring rules shown in Table 2. 20 smoking evaluators conduct a double-blind test. If at least 15 people among the smoking evaluators have the same evaluation result for a certain evaluation item, the evaluation result is recognized, otherwise the result is considered invalid and the evaluation is carried out again. The final evaluation result takes the average value. The higher the score, the better the smoking evaluation effect.

[0117] Table 2

[0118]

[0119] (3) Test results: As shown in Table 3, the tobacco alkaloid inclusion complex provided by the present invention has safe components and has better sensory smoking evaluation quality compared with commercially available products. The binder and the dispersant cooperate with each other, and at a specific ratio, the long-term and uniform sustained release of tobacco alkaloids in the oral cavity is achieved, and it has better sensory smoking evaluation quality. Pectin, konjac gum and β-cyclodextrin in the binder have a synergistic effect, and the embedding network constructed by them is more suitable for the long-term sustained release of tobacco alkaloids compared with other binders, and it has better sensory smoking evaluation quality. Calcium hydrogen phosphate, stearamide and glycerol distearate in the dispersant have a synergistic effect, and the embedding network constructed by them is more suitable for the long-term sustained release of tobacco alkaloids compared with other dispersants, and it has better sensory smoking evaluation quality.

[0120] Table 3

[0121]

[0122]

[0123] The applicant declares that the present invention uses the above embodiments to illustrate a tobacco alkaloid inclusion and its preparation method and application, but the present invention is not limited to the above embodiments, that is, it does not mean that the present invention must rely on the above embodiments to be implemented. Those skilled in the art should understand that any improvement to the present invention, the equivalent replacement of each raw material of the product of the present invention, the addition of auxiliary components, the selection of specific methods, etc. all fall within the protection scope and the disclosure scope of the present invention.

[0124] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0125] In addition, it should be noted that in the above specific embodiments, the various specific technical features described can be combined in any suitable manner without conflict. To avoid unnecessary repetition, the present invention will not separately describe various possible combination methods.

Claims

1. A tobacco alkaloid inclusion, characterized in that, The components of the tobacco alkaloid inclusion complex include a filler, a tobacco alkaloid or its salt, a binder, and a dispersant; The binder includes a combination of at least two of pectin, konjac gum, β-cyclodextrin, xanthan gum, gum arabic, guar gum, carrageenan, or sodium alginate; the dispersant includes a combination of at least two of calcium hydrogen phosphate, stearamide, glyceryl distearate, lecithin, magnesium stearate, or calcium chloride.

2. The tobacco alkaloid inclusion complex according to claim 1, wherein The components of the tobacco alkaloid inclusion complex, by weight, include 30 - 50 parts of a filler, 1 - 20 parts of a tobacco alkaloid or its salt, 20 - 30 parts of a binder, and 1 - 5 parts of a dispersant.

3. The tobacco alkaloid inclusion complex according to claim 1 or 2, characterized in that, The tobacco alkaloid includes any one or a combination of at least two of nicotine, nornicotine, anatabine, or anabaseine; the tobacco alkaloid salt includes any one or a combination of at least two of the citrate, malate, tartrate, salicylate, or hydrochloride of the tobacco alkaloid.

4. The tobacco alkaloid inclusion complex according to any one of claims 1-3, characterized in that, The binder includes pectin, konjac gum, and β-cyclodextrin; Preferably, the dispersant includes calcium hydrogen phosphate, stearamide, and glyceryl distearate.

5. The tobacco alkaloid inclusion complex according to any one of claims 1-4, characterized in that, The filler includes any one or a combination of at least two of soybean dregs, coffee grounds, tea dregs, fruit peel dregs, or distillers' grains; Preferably, the components of the tobacco alkaloid inclusion complex, by weight, further include 10 - 20 parts of a flavoring agent; Preferably, the flavoring agent includes any one or a combination of at least two of edible salt, maltose, fructose, glucose, sucrose, sucralose, saccharin, aspartame, sodium cyclamate, or acesulfame potassium; Preferably, the components of the tobacco alkaloid inclusion complex, by weight, further include 1 - 10 parts of edible oil; Preferably, the edible oil includes any one or a combination of at least two of butter, soybean oil, corn oil, peanut oil, olive oil, rapeseed oil, sunflower oil, or sesame oil.

6. The preparation method of the tobacco alkaloid inclusion complex according to any one of claims 1-5, characterized in that, The preparation method includes: (1) Mix the filler with the tobacco alkaloid or its salt in water, let it stand, and obtain a mixture; (2) Mix the mixture obtained in step (1) with the binder and the dispersant in water, granulate, and dry to obtain the tobacco alkaloid inclusion complex.

7. The preparation method according to claim 6, characterized in that, In step (1), the preparation process of the tobacco alkaloid salt includes: mixing the tobacco alkaloid with an acidity regulator, adjusting the pH value to 5 - 6, and obtaining the tobacco alkaloid salt; Preferably, the acidity regulator includes any one or a combination of at least two of an aqueous solution of citric acid, an aqueous solution of malic acid, an aqueous solution of tartaric acid, an aqueous solution of salicylic acid, or an aqueous solution of hydrochloric acid.

8. The preparation method according to claim 6, wherein In step (1), the mixing method is stirring; Preferably, the mixing time is 10 - 30 min; Preferably, the standing temperature is 40 - 50 °C, and the standing time is 2 - 4 h; Preferably, after standing, it further includes the steps of freeze-drying and grinding into powder.

9. The preparation method according to claim 6, characterized in that, In step (2), the mixing method is stirring; Preferably, during the mixing process, a flavoring agent and edible oil are further added; Preferably, the drying method is drying by baking; Preferably, the drying temperature is 40 - 60 °C, and the drying time is 1 - 3 h.

10. Use of the tobacco alkaloid inclusion complex according to any one of claims 1 - 5 in the preparation of a mouth tobacco.

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