A device for concentrating a raw material of deferasirox

Abstract

The present application relates to the technical field of concentration, and particularly relates to a concentration device for preparing deferasirox raw material, which comprises a box and other components, a liquid storage area and a concentration area are arranged in the box in an up-down mode, the liquid storage area and the concentration area are connected through at least one pipeline, at least one liquid inlet is arranged on the pipeline, a vacuum pump is connected to the outer wall of the concentration area, a second temperature control rod is arranged in the concentration area, at least one concentration cylinder is arranged in the concentration area, and the concentration cylinder is connected with the pipeline. The concentration device is provided with a box, a concentration cylinder and a first spiral blade, the boiling point of the solution is reduced through a vacuum environment, multiple concentration cylinders are arranged for high-temperature concentration, the originally equal amount of solution is divided into multiple groups for high-temperature concentration, the time of high-temperature concentration is shortened, partial active components are prevented from being damaged by heat, then low-temperature concentration is adopted in the last stage of concentration, the temperature is further reduced to ensure that the heat-sensitive components in the solution remain stable, and finally high-concentration deferasirox raw material solution is obtained.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of concentration, in particular to a concentration device for preparing delferirone raw materials. BACKGROUND

[0002] Delferirone is the first conventional oral iron chelator approved by the US FDA, especially suitable for patients over 2 years old with excessive iron overload due to blood transfusion. In Europe, delferirone is listed as the first-line treatment drug for patients with thalassemia iron overload over 6 years old. In the synthesis process of delferirone, the concentration of some intermediates or reaction solutions in the solution is low, which may need to be concentrated by solvent evaporation and other methods to improve the reaction efficiency and ensure the smooth progress of subsequent reactions.

[0003] The existing concentration device, such as the patent with the authorization announcement number CN222195920U, discloses a concentration device for drug production, which can scrape the drug residues on the inner wall bottom to avoid residues. However, the solution may be heated for a long time at high temperature, which can easily cause excessive heating of the material, thereby affecting the chemical stability of delferirone at high temperature and causing product degradation. In view of this, the present application proposes a concentration device for preparing delferirone raw materials to solve the above technical problems. SUMMARY

[0004] In order to overcome the technical problems mentioned in the background art, the present application provides a concentration device for preparing delferirone raw materials.

[0005] The technical scheme is as follows: a concentration device for preparing delferirone raw materials, comprising a box body, a liquid storage area and a concentration area are arranged inside the box body, the liquid storage area and the concentration area are connected in communication by at least one pipeline, at least one liquid inlet is arranged on the pipeline, a lifting plate is sealingly and slidably connected in the liquid storage area, the lifting plate is driven to slide up and down by a first driving assembly, a vacuum pump is connected to the outer side wall of the concentration area, a second temperature control rod is arranged in the concentration area;

[0006] A concentration cylinder is arranged in the concentration area, the concentration cylinder is connected in communication with the pipeline, the concentration cylinder comprises a cylinder cover fixed to the top surface of the concentration area, a rotating cylinder is rotatably connected to the bottom surface of the cylinder cover, the rotating cylinder is driven to rotate by a second driving assembly, a bottom cover is arranged at the lower end of the rotating cylinder, the bottom cover is driven to seal or unseal the rotating cylinder by a third driving assembly, a stirring assembly and a heating cavity are arranged in the rotating cylinder, a first temperature control rod is arranged in the heating cavity, and the temperature of the first temperature control rod is higher than that of the second temperature control rod;

[0007] A filter assembly is installed in the concentration area and located directly below the concentration cylinder.

[0008] As a further preferred, the liquid storage area is divided into a first liquid inlet area and a second liquid inlet area by a partition, the first liquid inlet area and the second liquid inlet area are respectively provided with a first liquid inlet pipe and a second liquid inlet pipe on the side wall, the first liquid inlet pipe and the second liquid inlet pipe are respectively provided with a valve body, the first liquid inlet area and the second liquid inlet area are respectively provided with a lifting plate in a sealed sliding connection, the lifting plate is driven to slide up and down by a corresponding first driving assembly, two liquid inlet openings are symmetrically arranged on the pipe, and the two liquid inlet openings are respectively located in the first liquid inlet area and the second liquid inlet area, and a first spiral blade is fixedly connected to the lower end of the pipe.

[0009] As a further preferred, the stirring assembly comprises a fixed rod fixedly connected to the middle of the bottom surface of the cylinder cover, the pipe penetrates through the cylinder cover and extends into the interior of the rotating cylinder, the fixed rod is arranged in a gap with the lower end of the rotating cylinder, the fixed rod is uniformly provided with a second bevel gear, the rotating cylinder is uniformly provided with a first rotating rod in a rotating connection, the first rotating rod is fixedly connected with a stirring rod, the first rotating rod is fixedly connected with a first bevel gear at one end close to the second bevel gear, and the first bevel gear and the second bevel gear are in meshing connection.

[0010] As a further preferred, the liquid storage area and the concentration area are connected by at least two pipes, at least two concentration cylinders are arranged in the concentration area, the second driving assembly comprises a second driving motor arranged on the outer side wall of the concentration area, a fourth bevel gear is fixedly connected to the output shaft of the second driving motor, a third bevel gear meshing with the fourth bevel gear is arranged on one of the rotating cylinders, a driving gear is arranged on the rotating cylinder, and the adjacent two driving gears are in meshing connection.

[0011] As a further preferred, the third driving assembly comprises a first driving motor arranged on the outer side wall of the concentration area, and a second rotating rod is rotatably connected in the concentration area and fixedly connected with the bottom cover.

[0012] As a further preferred, the filtering assembly comprises a pull-out box in a sliding connection in the concentration area, the pull-out box is located directly below the concentration cylinder, a filter plate is in a sliding connection on the pull-out box, an elastic member is arranged between the filter plate and the pull-out box, at least one bottom cover is fixedly connected with a pressing rod, a special-shaped plate matched with the pressing rod is arranged on the top surface of the filter plate, and the special-shaped plate is in a "concave" shape.

[0013] As a further preferred, a mounting plate is fixedly connected in the concentration area, the front and rear sides of the mounting plate are in a slope shape, the middle part is in a circular arc shape, a driving rod is rotatably connected to the circular arc part of the mounting plate in the concentration area, a second spiral blade is fixedly connected to the side wall of the driving rod, the driving rod is connected with the output shaft of the second driving motor through a synchronous belt component, a second temperature control rod is arranged between the front and rear sides of the mounting plate and the inner wall of the concentration area, and a liquid outlet is arranged on the side of the concentration area away from the synchronous belt component.

[0014] As a further preferred scheme, the gas treatment assembly is further included, and at least two groups of gas treatment assemblies are installed on the top surface of the box, one of which is communicated with the vacuum pump, and the remaining gas treatment assemblies are communicated with the pipeline, the gas treatment assembly comprises a sealing cylinder fixed on the top surface of the box, and a gas outlet and a first gas inlet are arranged at the upper end and the lower end of the sealing cylinder respectively, a valve body is installed on the gas outlet, the first gas inlet is communicated with the corresponding pipeline or vacuum pump, a treatment box is slidably connected in the sealing cylinder, a semicircular limiting protrusion is arranged on the upper portion of the treatment box, and an activated carbon plate is slidably connected between the limiting protrusion and the treatment box, a second gas inlet is arranged on the bottom of the treatment box and communicated with the first gas inlet, a third rotating rod is rotatably connected in the second gas inlet, a rotating fan blade is fixed on the bottom of the third rotating rod, a scraping rod is fixed on the top of the third rotating rod, the scraping rod is in contact with the bottom of the activated carbon plate, and a check valve is installed at the liquid inlet.

[0015] As a further preferred scheme, the fixing rod and the driving rod are hollow, and the first temperature control rod and the second temperature control rod are respectively installed in the fixing rod and the driving rod.

[0016] As a further preferred scheme, an operation screen is further installed on the outer wall of the box, and the operation screen is electrically connected with all the electrical elements.

[0017] The present application has the following advantages: the present application is provided with a box, a concentration cylinder and a first spiral blade, the boiling point of the solution is reduced in a vacuum environment, a plurality of concentration cylinders are provided for high-temperature concentration, the same amount of solution is divided into multiple groups for high-temperature concentration, the time of high-temperature concentration is shortened, and partial active ingredients are prevented from being destroyed by heat, then low-temperature concentration is carried out in the last stage of concentration, the heat-sensitive components in the solution are ensured to be stable by further reducing the temperature, the solution is further concentrated, and finally a high-concentration deferasirox raw material solution is obtained. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is a structural schematic diagram of the present application.

[0019] Figure 2 It is another structural schematic diagram of the present application.

[0020] Figure 3 It is a sectional view of the present application.

[0021] Figure 4 It is a sectional view of the box, the partition plate and the lifting plate and other components of the present application.

[0022] Figure 5 It is a sectional view of the pipeline and the first spiral blade of the present application.

[0023] Figure 6 It is a sectional view of the concentration cylinder and other components of the present application.

[0024] Figure 7 The cross-sectional view of the stirring assembly and other components of the present application.

[0025] Figure 8 The schematic view of the concentrating cylinder, filter assembly and mounting plate and other components of the present application.

[0026] Figure 9 Another schematic view of the concentrating cylinder, filter assembly and mounting plate and other components of the present application.

[0027] Figure 10 The first state view of the bottom cover, extrusion rod and special-shaped plate of the present application.

[0028] Figure 11 The second state view of the bottom cover, extrusion rod and special-shaped plate of the present application.

[0029] Figure 12 The cross-sectional view of the gas processing assembly of the present application.

[0030] Figure 13 The schematic view of the activated carbon plate, scraping rod and processing box and other components of the present application.

[0031] Wherein: 1 - box, 11 - liquid storage area, 111 - first liquid inlet area, 112 - second liquid inlet area, 12 - concentration area, 13 - first liquid inlet pipe, 14 - second liquid inlet pipe, 15 - liquid outlet, 21 - pipeline, 211 - liquid inlet, 22 - lifting plate, 23 - vacuum pump, 24 - second temperature control rod, 25 - concentrating cylinder, 251 - cylinder cover, 252 - rotating cylinder, 2521 - heating cavity, 253 - bottom cover, 26 - first temperature control rod, 27 - first helical blade, 28 - partition plate, 31 - fixed rod, 32 - second bevel gear, 33 - first rotating rod, 34 - stirring rod, 35 - first bevel gear, 41 - second drive motor, 42 - fourth bevel gear, 43 - third bevel gear, 44 - drive gear, 51 - first drive motor, 52 - second rotating rod, 61 - pull-out box, 62 - filter plate, 63 - elastic member, 64 - extrusion rod, 65 - special-shaped plate, 71 - mounting plate, 72 - drive rod, 73 - second helical blade, 74 - synchronous belt component, 81 - sealing cylinder, 811 - first air inlet, 812 - air outlet, 82 - processing box, 821 - limiting protrusion, 822 - second air inlet, 83 - activated carbon plate, 84 - third rotating rod, 85 - rotating fan blade, 86 - scraping rod, 91 - operation screen, 92 - electric push rod. DETAILED DESCRIPTION

[0032] The application will be further described in connection with the specific embodiments. It needs to be pointed out that unless otherwise explicitly specified and limited, the terms such as setting, installing, connecting, and linking should be understood in a broad sense. For example, it can be fixed connection, detachable connection, or integral connection; it can be mechanical connection, or electrical connection; it can be direct connection, or indirect connection through intermediate medium; it can be internal connection of two elements. For ordinary skilled in the art, the specific meaning of the above terms in the application can be understood according to the specific circumstances.

[0033] A kind of concentrated device for preparing deferasirox raw material, as shown in Figures 1-13 The box 1 is provided with a liquid storage area 11 and a concentration area 12 from top to bottom. The liquid storage area 11 is divided into a first liquid inlet area 111 and a second liquid inlet area 112 by a partition 28. The side walls of the first liquid inlet area 111 and the second liquid inlet area 112 are respectively provided with a first liquid inlet pipe 13 and a second liquid inlet pipe 14. The first liquid inlet pipe 13 and the second liquid inlet pipe 14 are respectively provided with a valve body, which is an electromagnetic valve. The valve body is used to open or close the passage of the first liquid inlet pipe 13 and the second liquid inlet pipe 14. The first liquid inlet area 111 is filled with a deferasirox raw material solution, and the second liquid inlet area 112 is filled with an auxiliary material (such as a pH regulator) to help optimize the concentration process and improve product quality. The first liquid inlet area 111 and the second liquid inlet area 112 are respectively provided with a lifting plate 22 which is connected in a sealed sliding manner. The lifting plate 22 is driven to slide up and down by a corresponding first driving assembly. The first driving assembly is an electric push rod 92 installed on the top surface of the box 1. The extension rod of the electric push rod 92 is fixedly connected with the corresponding lifting plate 22. In other embodiments, a lifting device can be used to achieve the same effect. The liquid storage area 11 and the concentration area 12 are connected by five pipes 21. The five pipes 21 are evenly distributed. Two liquid inlets 211 are symmetrically arranged on the pipe 21. The two liquid inlets 211 are respectively located in the first liquid inlet area 111 and the second liquid inlet area 112. The liquid level in the first liquid inlet area 111 and the second liquid inlet area 112 is lower than the liquid inlets 211. A first spiral blade 27 is fixedly connected to the lower end of the pipe 21. When the solution in the first liquid inlet area 111 and the second liquid inlet area 112 flows from the liquid storage area 11 to the concentration area 12, the first spiral blade 27 can mix the two solutions, so that they can be more fully contacted, which helps the auxiliary material to play a better role, optimizes the concentration process, and improves the product quality.

[0034] A vacuum pump 23 is communicated with the outer wall of the concentration area 12, a second temperature control rod 24 is arranged in the concentration area 12, five concentration cylinders 25 are installed in the concentration area 12, the concentration cylinder 25 is communicated with the corresponding pipeline 21, the concentration cylinder 25 comprises a cylinder cover 251 fixed on the top surface of the concentration area 12, a rotating cylinder 252 is rotatably connected to the bottom surface of the cylinder cover 251, the rotating cylinder 252 is driven to rotate by a second driving assembly, a bottom cover 253 is arranged at the lower end of the rotating cylinder 252, the bottom cover 253 is driven to realize the sealing or non-sealing of the rotating cylinder 252 by a third driving assembly, a stirring assembly and a heating cavity 2521 are arranged in the rotating cylinder 252, a first temperature control rod 26 is arranged in the heating cavity 2521, the first temperature control rod 26 is installed on the bottom surface of the cylinder cover 251, the temperature of the first temperature control rod 26 is higher than that of the second temperature control rod 24, and a filtering assembly is installed in the concentration area 12 and located directly below the concentration cylinder 25;

[0035] Therefore, when concentration is needed, first, the valve body on the first liquid inlet pipe 13 and the second liquid inlet pipe 14 is closed, then the third driving assembly is started, so that the bottom cover 253 is not sealed with the rotating cylinder 252, and then the storage area 11 and the concentration area 12 are communicated, then the vacuum pump 23 is used to vacuum the inside of the box 1, so as to reduce the pressure in the box 1, then the third driving assembly is started, so that the bottom cover 253 is sealed with the rotating cylinder 252, the storage area 11 and the concentration area 12 are not communicated, the valve body on the first liquid inlet pipe 13 and the second liquid inlet pipe 14 is opened, and then the deferasirox raw material solution and the auxiliary material solution are respectively injected into the first liquid inlet area 111 and the second liquid inlet area 112 through the first liquid inlet pipe 13 and the second liquid inlet pipe 14, the liquid level of the two solutions is lower than the liquid inlet 211, after the liquid surface is calm, the first driving assembly is started, that is, the electric push rod 92 is started, the telescopic rod of the electric push rod 92 is retracted, so that the lifting plate 22 moves upward, and then the solution in the first liquid inlet area 111 and the second liquid inlet area 112 is lifted, so that the liquid level is higher than the liquid inlet 211, and then the solution flows into the pipe 21, the height and the rate at which the lifting plate 22 is lifted by the electric push rod 92 are controlled, so that the speed and the flow of the solution entering the pipe 21 can be controlled, so that the raw material and the auxiliary material can be optimally matched, and the activity and the stability of the final product can be ensured, after the two solutions enter the pipe 21, the two solutions flow downward freely under the action of gravity, and the two solutions are stirred and mixed by the first spiral blade 27 in the flowing process, so that the two solutions can be more fully contacted, and the auxiliary material can better play a role, and finally the two solutions are combined into a new solution and fall into the concentration cylinder 25, then the first temperature control rod 26 is started for high-temperature heating, and then the new solution is high-temperature concentrated in the rotating cylinder 252, because the high-temperature concentration is in a relative vacuum environment, the boiling point of the solution is lowered, the first temperature control rod 26 strictly controls the temperature, so that the temperature is in a proper range and is not too high, and the high-temperature concentration time is short, so that the degradation of some heat-sensitive components (for example, some active pharmaceutical ingredients) can be avoided, so that when the high-temperature concentration is performed, some volatile substances are removed first, so that the volume of the solution is reduced, and then some solid impurities are precipitated, then the third driving assembly is started, so that the bottom cover 253 is not sealed with the rotating cylinder 252, the solution in the concentration cylinder 25 falls into the concentration area 12, the precipitated solid impurities are filtered out by the filtering assembly, and the solution falls into the bottom of the concentration area 12, the second temperature control rod 24 is started to heat the solution at low temperature, so that the solution is low-temperature concentrated in the concentration area 12, and the concentration effect is further improved, and finally the high-concentration deferasirox raw material solution is obtained, so that the boiling point of the solution is lowered by the vacuum environment, a plurality of concentration cylinders 25 are arranged for high-temperature concentration, the same amount of solution is divided into a plurality of groups for high-temperature concentration, the high-temperature concentration time is shortened, and some active components are prevented from being damaged by heat, then the low-temperature concentration is performed in the last stage of the concentration, and the temperature is further lowered to ensure that the heat-sensitive components in the solution remain stable,The solution is further concentrated, and finally a high-concentration deferasirox raw material solution is obtained.

[0036] Further, in order to make the effect of high-temperature concentration better, the stirring assembly comprises a fixed rod 31 fixedly connected to the middle part of the bottom surface of the cylinder cover 251, the pipeline 21 penetrates through the cylinder cover 251 and extends into the interior of the rotating cylinder 252, the fixed rod 31 is arranged in a gap with the lower end of the rotating cylinder 252, the second bevel gear 32 is uniformly distributed on the fixed rod 31, the first rotating rod 33 is uniformly distributed and rotationally connected in the rotating cylinder 252, the stirring rod 34 is fixedly connected to the first rotating rod 33, the first bevel gear 35 is fixedly connected to one end of the first rotating rod 33 close to the second bevel gear 32, and the first bevel gear 35 is meshed with the second bevel gear 32; the second driving assembly comprises a second driving motor 41 mounted on the outer side wall of the concentration area 12, a fourth bevel gear 42 is fixedly connected to the output shaft of the second driving motor 41, one of the rotating cylinders 252 is provided with a third bevel gear 43 meshed with the fourth bevel gear 42, and a driving gear 44 is mounted on the rotating cylinder 252; adjacent two driving gears 44 are meshed with each other. As can be seen, the second driving motor 41 is started, the output shaft of the second driving motor 41 drives the fourth bevel gear 42 to rotate, the fourth bevel gear 42 drives the third bevel gear 43 to rotate through meshing transmission, and then drives the rotating cylinder 252 to rotate, the rotating cylinder 252 drives the first rotating rod 33 to rotate around the fixed rod 31, and then the first bevel gear 35 rotates around the second bevel gear 32, and the first bevel gear 35 is meshed with the second bevel gear 32, so that the first bevel gear 35 rotates, the first bevel gear 35 rotates to drive the first rotating rod 33 to rotate, and then the first rotating rod 33 drives the stirring rod 34 to rotate. In this way, the first rotating rod 33 keeps stirring the solution in the horizontal direction, and at the same time, the stirring rod 34 forms a vortex in the vertical direction, providing bidirectional stirring, breaking the layers of the solution, so that the bottom solution can exchange with the upper solution. In this way, not only the uniformity of the solution is improved, but also the contact area between the solution and the heat source is increased, so as to accelerate heat transfer and improve the efficiency of the high-temperature concentration process. At the same time, it can ensure that the substances in the rotating cylinder 252 are fully mixed, effectively avoid the formation of dead zones or areas not stirred in the solution, and avoid the unevenness of the concentration process.

[0037] The third driving assembly comprises a first driving motor 51 mounted on the outer side wall of the concentration area 12, and a second rotating rod 52 rotationally connected in the concentration area 12 and fixedly connected to the bottom cover 253. As can be seen, the first driving motor 51 is started, and then the output shaft of the first driving motor 51 drives the second rotating rod 52 to rotate, and then the second rotating rod 52 drives the bottom cover 253 to rotate, so that the bottom cover 253 can be sealed or unsealed with the rotating cylinder 252.

[0038] Furthermore, to remove solid impurities from the liquid after high-temperature concentration, the filter assembly includes a pull-out box 61 slidably connected within the concentration zone 12. The pull-out box 61 is located directly below the concentration cylinder 25. A filter plate 62 is slidably connected to the pull-out box 61. An elastic element 63, specifically a spring, is provided between the filter plate 62 and the pull-out box 61. Extrusion rods 64 are fixedly connected to the bottom covers 253 on both sides. A shaped plate 65, which cooperates with the extrusion rods 64, is installed on the top surface of the filter plate 62. The shaped plate 65 is U-shaped. Therefore, when the bottom cover 253 is opened, the extrusion rods 64 on the bottom cover 253 will extrude the shaped plate 65, thereby causing the shaped plate 65 to move the filter plate 62 up and down. Figure 10 As shown, the filter plate 62 then compresses the elastic element 63, causing the elastic element 63 to store elastic potential energy. Since the irregular plate 65 is U-shaped, when the extrusion rod 64 moves to the middle of the irregular plate 65, the elastic element 63 releases its elastic potential energy, causing the filter plate 62 to reset. This allows the filter plate 62 to vibrate once. As the extrusion rod 64 continues to rotate, it will compress the irregular plate 65 again, causing the filter plate 62 to vibrate again. This prevents solid impurities from clogging the filter plate 62 and prevents the accumulation of solid impurities.

[0039] Furthermore, a mounting plate 71 is fixedly connected within the concentration zone 12. The mounting plate 71 has sloping sides and an arc-shaped center. A drive rod 72 is rotatably connected within the concentration zone 12 at the arc-shaped part of the mounting plate 71. A second spiral blade 73 is fixedly connected to the side wall of the drive rod 72. The drive rod 72 is connected to the output shaft of the second drive motor 41 via a synchronous belt component 74. A second temperature control rod 24 is installed between the mounting plate 71 and the inner wall of the concentration zone 12. An outlet 15 is provided on the side of the concentration zone 12 away from the synchronous belt component 74. Thus, when the solution falls into the concentration zone 12, it will fall directly into the arc-shaped area of ​​the mounting plate 71. When the output shaft of the second drive motor 41 rotates, it drives the drive rod 72 to rotate via the synchronous belt component 74. In turn, the drive rod 72 drives the second spiral blade 73 to rotate, thereby continuously stirring the solution and conveying it to the outlet 15. At the same time, the second temperature control rod 24 is activated to concentrate the solution at a low temperature.

[0040] Further, in order to treat the concentrated gas, the gas treatment assembly is further included, six groups of gas treatment assemblies are installed on the top surface of the box 1, one of the gas treatment assemblies is communicated with the vacuum pump 23, and the remaining gas treatment assemblies are communicated with the pipeline 21, the gas treatment assembly comprises a sealing cylinder 81 fixedly connected to the top surface of the box 1, an air outlet 812 and a first air inlet 811 are arranged at the upper and lower ends of the sealing cylinder 81 respectively, a valve body is installed on the air outlet 812, the first air inlet 811 is communicated with the corresponding pipeline 21 or the vacuum pump 23, a treatment box 82 is slidably connected in the sealing cylinder 81, a semicircular limiting protrusion 821 is arranged on the upper portion of the treatment box 82, an activated carbon plate 83 is slidably connected between the limiting protrusion 821 and the treatment box 82, a second air inlet 822 is arranged on the bottom of the treatment box 82, the second air inlet 822 is communicated with the first air inlet 811, a third rotating rod 84 is rotatably connected in the second air inlet 822, a rotating fan blade 85 is fixedly connected to the bottom of the third rotating rod 84, a scraping rod 86 is fixedly connected to the top of the third rotating rod 84, the scraping rod 86 is in contact with the bottom of the activated carbon plate 83, and a one-way valve is installed at the liquid inlet 211, so that the concentrated gas enters the sealing cylinder 81 from the first air inlet 811 and the second air inlet 822, the activated carbon plate 83 can adsorb the concentrated gas, and then the filtered gas flows into the outside through the air outlet 812, when the gas flows, the rotating fan blade 85 rotates, then the third rotating rod 84 rotates driven by the rotating fan blade 85, and then the scraping rod 86 rotates driven by the third rotating rod 84, the scraping rod 86 can clean the bottom surface of the activated carbon plate 83, so as to prevent the adsorbed material from blocking the holes on the activated carbon plate 83, and the limiting protrusion 821 can prevent the gas from blowing the activated carbon plate 83, so that the activated carbon plate 83 shakes up and down, and the replacement of the activated carbon plate 83 is more convenient.

[0041] Further, the fixing rod 31 and the driving rod 72 are hollow, and the first temperature control rod 26 and the second temperature control rod 24 are respectively installed in the fixing rod 31 and the driving rod 72, so that the concentration effect is better.

[0042] Further, the operation screen 91 is further installed on the outer side wall of the box 1, and the operation screen 91 is electrically connected with all the electrical elements, so that the staff can operate conveniently.

[0043] The above merely shows the specific implementation of the present application, but the protection scope of the present application is not limited to this, any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the present application, which should be covered in the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.

Claims

1. A device for concentrating a raw material of deferasirox, characterized by: The application relates to a liquid concentration device, which comprises a box (1), a liquid storage area (11) and a concentration area (12) arranged in the box (1) in a vertical mode, at least one pipeline (21) is arranged between the liquid storage area (11) and the concentration area (12) to realize communication, at least one liquid inlet (211) is arranged on the pipeline (21), a lifting plate (22) is sealingly and slidably connected in the liquid storage area (11), the lifting plate (22) is driven by a first driving assembly to realize vertical sliding, a vacuum pump (23) is arranged on the outer side wall of the concentration area (12), a second temperature control rod (24) is arranged in the concentration area (12); At least one concentration cylinder (25) is arranged in the concentration area (12), the concentration cylinder (25) is communicated with the pipeline (21), the concentration cylinder (25) comprises a cylinder cover (251) fixed on the top surface of the concentration area (12), a rotating cylinder (252) is rotatably connected to the bottom surface of the cylinder cover (251), the rotating cylinder (252) is driven to rotate by a second driving assembly, a bottom cover (253) is arranged at the lower end of the rotating cylinder (252), the bottom cover (253) is driven by a third driving assembly to realize sealing or non-sealing of the rotating cylinder (252), a stirring assembly and a heating cavity (2521) are arranged in the rotating cylinder (252), a first temperature control rod (26) is arranged in the heating cavity (2521), the temperature of the first temperature control rod (26) is higher than that of the second temperature control rod (24); A filtering assembly is arranged in the concentration area (12) and located directly below the concentration cylinder (25); The liquid storage area (11) is divided into a first liquid inlet area (111) and a second liquid inlet area (112) by a partition plate (28), a first liquid inlet pipe (13) and a second liquid inlet pipe (14) are arranged on the side walls of the first liquid inlet area (111) and the second liquid inlet area (112) respectively, valve bodies are arranged on the first liquid inlet pipe (13) and the second liquid inlet pipe (14), lifting plates (22) are sealingly and slidably connected in the first liquid inlet area (111) and the second liquid inlet area (112), the lifting plates (22) are driven by corresponding first driving assemblies to realize vertical sliding, two liquid inlets (211) are symmetrically arranged on the pipeline (21) and located in the first liquid inlet area (111) and the second liquid inlet area (112) respectively, and a first spiral blade (27) is fixedly connected to the lower end of the pipeline (21); At least two pipelines (21) are arranged between the liquid storage area (11) and the concentration area (12) to realize communication, at least two concentration cylinders (25) are arranged in the concentration area (12), the second driving assembly comprises a second driving motor (41) arranged on the outer side wall of the concentration area (12), a fourth helical gear (42) is fixedly connected to the output shaft of the second driving motor (41), a third helical gear (43) meshing with the fourth helical gear (42) is arranged on one of the rotating cylinders (252), driving gears (44) are arranged on the rotating cylinders (252), and the adjacent two driving gears (44) are meshed with each other. The filter assembly comprises a pull-out box (61) slidably connected in the concentration area (12), the pull-out box (61) is located directly below the concentration cylinder (25), a filter plate (62) is slidably connected on the pull-out box (61), an elastic member (63) is arranged between the filter plate (62) and the pull-out box (61), at least one bottom cover (253) is fixedly connected with an extrusion rod (64), a special-shaped plate (65) is mounted on the top surface of the filter plate (62) and matched with the extrusion rod (64), and the special-shaped plate (65) is in a "concave" shape; The installation plate (71) is fixedly connected in the concentration area (12), the front and rear sides of the installation plate (71) are inclined, the middle part is arc-shaped, a drive rod (72) is rotatably connected in the arc-shaped part of the installation plate (71) in the concentration area (12), a second spiral blade (73) is fixedly connected on the side wall of the drive rod (72), the drive rod (72) is connected with the output shaft of the second drive motor (41) through a synchronous belt component (74), a second temperature control rod (24) is mounted between the front and rear sides of the installation plate (71) and the inner wall of the concentration area (12), and a liquid outlet (15) is arranged on the side of the concentration area (12) away from the synchronous belt component (74); The gas treatment assembly is further arranged on the top surface of the box body (1), one of the gas treatment assemblies is communicated with the vacuum pump (23), and the remaining gas treatment assemblies are communicated with the pipeline (21), the gas treatment assembly comprises a sealing cylinder (81) fixedly connected on the top surface of the box body (1), gas outlets (812) and first air inlets (811) are arranged at the upper and lower ends of the sealing cylinder (81) respectively, a valve body is mounted on the gas outlet (812), the first air inlet (811) is communicated with the corresponding pipeline (21) or vacuum pump (23), a treatment box (82) is slidably connected in the sealing cylinder (81), a semicircular limiting protrusion (821) is arranged on the upper portion of the treatment box (82), an activated carbon plate (83) is slidably connected between the limiting protrusion (821) and the treatment box (82), a second air inlet (822) is arranged on the bottom of the treatment box (82), the second air inlet (822) is communicated with the first air inlet (811), a third rotating rod (84) is rotatably connected in the second air inlet (822), a rotating fan blade (85) is fixedly connected to the bottom of the third rotating rod (84), a scraping rod (86) is fixedly connected to the top of the third rotating rod (84), the scraping rod (86) is in contact with the bottom of the activated carbon plate (83), and a check valve is mounted at the liquid inlet (211).

2. A device for concentrating deferasirox raw material according to claim 1, characterized in that: The stirring assembly comprises a fixed rod (31) fixed in the middle of the bottom surface of the barrel cover (251), the pipeline (21) penetrates through the barrel cover (251) and extends into the inside of the rotating barrel (252), the fixed rod (31) is arranged in a gap with the lower end of the rotating barrel (252), the fixed rod (31) is uniformly distributed with second bevel gears (32), the rotating barrel (252) is uniformly distributed and rotationally connected with first rotating rods (33), the first rotating rods (33) are fixed with stirring rods (34), one end of the first rotating rod (33) close to the second bevel gear (32) is fixed with a first bevel gear (35), and the first bevel gear (35) is meshed with the second bevel gear (32).

3. A device for concentrating deferasirox raw material as claimed in claim 1, characterized in that: The third driving assembly comprises a first driving motor (51) installed on the outer side wall of the concentration area (12), and a second rotating rod (52) rotationally connected in the concentration area (12), and the second rotating rod (52) is fixed with the bottom cover (253).

4. A device for concentrating deferasirox raw material as claimed in claim 1, wherein: The fixed rod (31) and the driving rod (72) are both hollow, and the first temperature control rod (26) and the second temperature control rod (24) are respectively installed in the fixed rod (31) and the driving rod (72).

5. A device for concentrating deferasirox raw material as claimed in claim 1, wherein: The box body (1) is further provided with an operation screen (91) on the outer side wall, and the operation screen (91) is electrically connected with all the electric elements.

Images