Chromatographic column filling device

Abstract

The present invention relates to the field of chromatography analysis technology, and discloses a chromatography column filling device, comprising a chromatography column body and a support seat, wherein the top of the chromatography column body is provided with a feed end, the bottom of the chromatography column body is provided with a discharge end, and the discharge end is provided with a valve; a power mechanism, a Y-axis mechanism, a metering plate mechanism and a stacking mechanism are provided in the chromatography column body; the power mechanism is connected to the Y-axis mechanism, the Y-axis mechanism is connected to the stacking mechanism, and the metering plate mechanism is arranged on the Y-axis mechanism; the Y-axis mechanism comprises an upper connecting column, which is connected to the power mechanism, a guide rotating cylinder is provided at the bottom of the upper connecting column, a guide groove is provided on the upper surface of the guide rotating cylinder, a bottom connecting cylinder is provided at the bottom of the guide rotating cylinder, an outer lifting column is provided on the outer side of the guide rotating cylinder, and limit rods are provided on both sides of the upper portion of the outer lifting column. Beneficial effects: It solves the trouble and labor required for manual operation in the existing process, improves the filling efficiency, and at the same time does not require additional vibration devices on the periphery, thus solving the problem of complex structure.

Description

Technical Field

[0001] The present invention relates to the technical field of chromatography analysis, in particular to a chromatography column filling device. Background Art

[0002] Chromatography is a separation and analysis method, with separation being its core. Therefore, the chromatographic column, which performs this function, is the heart of the chromatographic system. Many factors influence the performance of a chromatographic column, including the properties and shape of the chromatographic packing, as well as its particle size and uniformity. The more uniform the packing, the less longitudinal diffusion, and the higher the column efficiency. Therefore, proper column filling is crucial.

[0003] To increase the filling rate of a chromatographic column, a short stick is typically used to continuously tap the column during the filling process, thereby promoting the filling of the filler within the column. This process undoubtedly increases the workload of the operator and has low filling efficiency. Furthermore, while external vibration devices are currently being used to tap the column to promote filling, this undoubtedly increases the total area and cost, and the structure of the column filling device with the additional vibration device becomes complicated, resulting in poor filling results. Summary of the Invention

[0004] The technical task of the present invention is to provide a chromatographic column filling device to solve the above problems.

[0005] The technical solution of the present invention is achieved as follows:

[0006] The chromatographic column filling device comprises a chromatographic column body and a bracket seat, the top of the chromatographic column body is provided with a feed end, the bottom of the chromatographic column body is provided with a discharge end, and the discharge end is provided with a valve; the chromatographic column body is provided with a power mechanism, a Y-axis mechanism, a metering plate mechanism and a stacking mechanism; the power mechanism is connected to the Y-axis mechanism, the Y-axis mechanism is connected to the stacking mechanism, and the metering plate mechanism is arranged on the Y-axis mechanism; the Y-axis mechanism comprises an upper connecting column, the upper connecting column is connected to the power mechanism, the bottom of the upper connecting column is provided with a guide rotating cylinder, the upper surface of the guide rotating cylinder is provided with a guide groove 1, the bottom of the guide rotating cylinder is provided with a bottom connecting cylinder, the outer side of the guide rotating cylinder is provided with an outer lifting column, the upper corresponding sides of the outer lifting column are provided with limit rods, the inner end of the limit rod is located in the guide groove 1, the bottom of the outer lifting column is provided with a lower connecting column, the lower connecting column is connected to the metering plate mechanism, the bottom connecting cylinder passes through the lower connecting column, and the bottom connecting cylinder is connected to the stacking mechanism.

[0007] Preferably, a first buffer block is provided on the chromatographic column body, a second buffer block is provided on the chromatographic column body at the bottom of the first buffer block, a third buffer block is provided at the lower part of the chromatographic column body, and the bracket seat is fixed on the third buffer block.

[0008] Preferably, the power mechanism is arranged at the feed end, and the power mechanism includes a rotating end block, which is embedded in the inner wall of the first buffer block. The rotating end block is provided with inner wall gear teeth, and the upper part of the upper connecting column is provided with an outer gear sleeve that engages with the inner wall gear teeth.

[0009] Preferably, an inner groove is provided on the inner wall of the second buffer block, and matching sliders are provided on the corresponding two sides of the inner groove, and the sides of the sliders away from the inner groove are respectively fixed on the side edges of the corresponding limit rods.

[0010] Preferably, a through-connected blanking channel is provided inside the upper connecting column, the guide rotating cylinder and the bottom connecting cylinder, and the bottom connecting cylinder passes through the metering plate mechanism.

[0011] Preferably, the metering plate mechanism includes a metering plate, a baffle plate is provided on the side of the metering plate, a metering base plate is provided on the bottom of the baffle plate, and a plurality of metering holes are provided on the metering plate and the metering base plate, and the metering holes are located inside the bottom connecting tube.

[0012] Preferably, the stacking mechanism includes an outer rotating cylinder, a hollow plate 1 is provided on the top of the outer rotating cylinder, the top of the hollow plate 1 is connected to the bottom of the bottom connecting cylinder, an inner lifting column is provided inside the outer rotating cylinder, a hollow plate 2 is provided on the top of the inner lifting column, a return spring is provided at the top center of the hollow plate 2, and the top of the return spring is fixed at the bottom center of the hollow plate 1; a plurality of limit columns are provided on the upper surface of the inner lifting column, and a guide groove 2 is provided on the inner wall of the outer rotating cylinder to cooperate with the limit columns.

[0013] Preferably, a cavity column is provided in the lower part of the third buffer block, and several discharge holes are provided at the top and bottom of the cavity column, the lower discharge holes correspond to the upper discharge holes, and several ropes are provided at the bottom of the cavity column, and a rubber ball is provided at the bottom of the ropes.

[0014] Compared with the prior art, the advantages and positive effects of the present invention are:

[0015] 1. The filling device includes a power mechanism, a Y-axis mechanism, a metering plate mechanism and a stacking mechanism. A power mechanism is provided at the feed port of the chromatographic column, the power mechanism is connected to the Y-axis mechanism, and the Y-axis mechanism is connected to the metering plate mechanism. When the power mechanism is running, it will drive the Y-axis mechanism and the metering plate mechanism to move downward as a whole, and transport the filler downward by generating a downward motion trajectory. During the transportation process, the filler is controlled to be not too large under the monitoring of the metering plate. At the same time, the Y-axis direction of the chromatographic column is kept from tilting during the filling operation. As the power mechanism is running, the filler forms a downward motion trajectory, and the vertical gravity generated squeezes the stacking mechanism arranged below the chromatographic column. The stacking mechanism is formed into a superposition under the action of force. After the superposition, the multiple rubber balls arranged below are caused to collide with each other under the action of inertia force. After the collision, the inner wall thereof is subjected to vibration force, and the generated vibration realizes filling, thereby solving the trouble and labor required for manual operation in the existing method, improving the filling efficiency, and solving the problem of complex structure without the need for additional vibration device around.

[0016] 2. After the Y-axis mechanism is running, the guide drum will rotate. The rotational motion will bring up the filler entering inside, and the filler will be transported downward along the rotation trajectory, providing a certain conveying motion and extrusion effect. After the guide drum rotates, it will bring up and down the external lifting column, and the external lifting column will bring up and down the metering plate mechanism connected below. After the metering plate mechanism hits the outer drum downward, the outer drum will generate vibration force. After the outer drum receives the vibration force, the residual force generated will affect the inner wall of the chromatographic column body, thereby improving the filling effect.

[0017] 3. The several metering holes on the metering plate and the metering bottom plate are set correspondingly. When the filler falling from above enters the metering hole, it will be squeezed inside under the influence of the metering hole. In this way, the amount of filler falling down will be controlled. When the outer lifting column moves up and down, it will bring the metering plate mechanism to continuously hit the stacking mechanism below. Under the vibration hammer force generated by the impact movement, the filler confined in the metering hole will fall down, which has a buffering and vibration effect on the falling material.

[0018] 4. Driven by the guide drum, the stacking mechanism causes the outer drum to rotate, and the outer drum drives the inner lifting column to achieve lifting motion, thereby causing the inner lifting column to hit the cavity column below. The cavity column is subjected to vibration force, and the rubber balls below will collide with each other, causing them to continuously hammer the inner wall of the chromatographic column.

[0019] 5. The chromatographic column here is a C18 chromatographic column, and the C18 chromatographic column is the material used in the kit for FDG synthesis. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 is a schematic diagram of the overall structure according to an embodiment of the present invention;

[0022] Figure 2 is a general cross-sectional view according to an embodiment of the present invention;

[0023] Figure 3 is a schematic diagram of the connection structure between the outer lifting column and the stacking mechanism according to an embodiment of the present invention;

[0024] Figure 4 is a schematic diagram of the Y-axis mechanism structure according to an embodiment of the present invention;

[0025] Figure 5 2. It is a schematic structural diagram of a guide drum according to an embodiment of the present invention;

[0026] Figure 6 is an exploded view of the connection between the Y-axis mechanism and the stacking mechanism according to an embodiment of the present invention;

[0027] Figure 7 is a schematic diagram of the structure of an inner lifting column according to an embodiment of the present invention;

[0028] Figure 8 is a schematic structural diagram of an outer drum according to an embodiment of the present invention;

[0029] Figure 9 2 is a schematic diagram of the unfolded structure of the outer drum according to an embodiment of the present invention.

[0030] In the picture:

[0031] 1. Chromatographic column body; 2. Bracket; 3. Feed end; 4. Discharge end; 5. Power mechanism; 6. Y-axis mechanism; 7. Measuring plate mechanism; 8. Lamination mechanism; 9. Upper connecting column; 10. Guide cylinder; 11. Guide groove 1; 12. Bottom connecting cylinder; 13. External lifting column; 14. Limit rod; 15. Lower connecting column; 16. First buffer block; 17. Second buffer block; 18. Third buffer block; 19. Rotating end Block; 20, inner wall gear; 21, outer gear sleeve; 22, inner slide; 23, slider; 24, baffle plate; 25, metering bottom plate; 26, metering plate; 27, metering hole; 28, outer rotating cylinder; 29, hollow plate one; 30, inner lifting column; 31, hollow plate two; 32, reset spring; 33, limit column; 34, guide groove two; 35, cavity column; 36, discharge hole; 37, rope; 38, rubber ball. DETAILED DESCRIPTION

[0032] In order to more clearly understand the above-mentioned objects, features and advantages of the present invention, the present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that, in the absence of conflict, the embodiments of the present application and the features therein can be combined with each other.

[0033] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0034] According to an embodiment of the present invention, Figures 1-9 Shown in:

[0035] The present invention provides a chromatographic column filling device, comprising a chromatographic column body 1 and a support base 2. The top of the chromatographic column body 1 is provided with a feed end 3, the bottom of the chromatographic column body 1 is provided with a discharge end 4, and the discharge end 4 is provided with a valve; a power mechanism 5, a Y-axis mechanism 6, a metering plate mechanism 7 and a stacking mechanism 8 are provided in the chromatographic column body 1; the power mechanism 5 is connected to the Y-axis mechanism 6, the Y-axis mechanism 6 is connected to the stacking mechanism 8, and the metering plate mechanism 7 is arranged on the Y-axis mechanism 6; the Y-axis mechanism 6 includes an upper connecting column 9, which is connected to the power mechanism 5, A guide drum 10 is provided at the bottom of the upper connecting column 9, a guide groove 11 is provided on the upper surface of the guide drum 10, a bottom connecting drum 12 is provided at the bottom of the guide drum 10, an outer lifting column 13 is provided on the outside of the guide drum 10, and limit rods 14 are provided on both sides of the upper part of the outer lifting column 13. The inner end of the limit rod 14 is located in the guide groove 11, and a lower connecting column 15 is provided at the bottom of the outer lifting column 13. The lower connecting column 15 is connected to the metering plate mechanism 7, and the bottom connecting drum 12 passes through the lower connecting column 15, and the bottom connecting drum 12 is connected to the stacking mechanism 8.

[0036] Among them, the chromatographic column body 1 is provided with a first buffer block 16, the bottom of the first buffer block 16 is located on the chromatographic column body 1 and a second buffer block 17 is provided, the lower part of the chromatographic column body 1 is provided with a third buffer block 18, the bracket seat 2 is fixed on the third buffer block 18, the power mechanism 5 is arranged at the feed end 3, the power mechanism 5 includes a rotating end block 19, the rotating end block 19 is embedded in the inner wall of the first buffer block 16, the rotating end block 19 is provided with an inner wall gear 20, the upper part of the upper connecting column 9 is provided with an outer gear sleeve 21 engaged with the inner wall gear 20, the inner wall of the second buffer block 17 is provided with an inner groove 22, and the corresponding two sides of the inner groove 22 are provided with matching sliders 23, and the slider 23 is fixed on the side of the corresponding limit rod 14 away from the inner groove 22. The upper connecting column 9, the guide rotating cylinder 10, and the bottom connecting cylinder 12 are provided with a through-connected blanking channel, and the bottom connecting cylinder 12 runs through the metering plate mechanism 7.

[0037] In addition, the metering plate mechanism 7 includes a metering plate 26, a baffle plate 24 is provided on the side of the metering plate 26, a metering bottom plate 25 is provided at the bottom of the baffle plate 24, and a plurality of metering holes 27 are provided on the metering plate 26 and the metering bottom plate 25. The metering hole 27 is located at the internal position of the bottom connecting cylinder 12. The stacking mechanism 8 includes an outer rotating cylinder 28, a hollow plate 29 is provided on the top of the outer rotating cylinder 28, and the top of the hollow plate 29 is connected to the bottom of the bottom connecting cylinder 12. An inner lifting column 30 is provided inside the outer rotating cylinder 28, and a hollow plate 21 is provided on the top of the inner lifting column 30. A return spring 32 is provided at the top center of the second 31, and the top of the return spring 32 is fixed at the bottom center of the hollow plate 1 29; a plurality of limit columns 33 are provided on the upper surface of the inner lifting column 30, and a guide groove 2 34 is provided on the inner wall of the outer rotating cylinder 28 to cooperate with the limit columns 33; a cavity column 35 is provided at the lower inner part of the third buffer block 18, and a plurality of discharge holes 36 are provided at the top and bottom of the cavity column 35, and the lower discharge hole 36 corresponds to the upper discharge hole 36; a plurality of ropes 37 are provided at the bottom of the cavity column 35, and a rubber ball 38 is provided at the bottom of the rope 37.

[0038] The cavity column 35 is arranged in the lower part of the third buffer block 18, and the outer rotating cylinder 28 is located above the third buffer block 18. The top of the outer rotating cylinder 28 is connected to the bottom of the bottom connecting cylinder 12, and the top of the bottom connecting cylinder 12 is connected to the bottom of the guide rotating cylinder 10. The upper part of the guide rotating cylinder 10 is provided with an outer gear sleeve 21, and the outer gear sleeve 21 is connected to the power mechanism 5. The drive of the power mechanism 5 can be achieved by providing an outer gear on the outside of the rotating end block 19, and a meshing gear is provided on the side of the outer gear. The drive shaft of the gear can be connected to a driver, and the driver is connected to the chromatographic column body 1 through a bracket. It is also possible to directly rotate the rotating end block 19 with the help of an external force. After the rotating end block 19 rotates, it will drive the internal outer gear sleeve 21, further driving the outer rotating cylinder 28 to rotate.

[0039] There is a certain distance between the metering plate 26 and the metering bottom plate 25, and a material blocking plate 24 is provided on the side of the metering plate 26 and the metering bottom plate 25, so that a cavity is formed inside. The metering hole 27 on the metering plate 26 corresponds to the metering hole 27 on the metering bottom plate 25, so that the path through the top and bottom is in a diameter state. After the filler enters the metering hole 27, there are certain limitations.

[0040] The apertures of the hollow holes on the hollow plate 1 29 and the hollow plate 2 31 are larger than the aperture of the metering hole 27 , and the apertures of the discharge holes 36 provided at the top and bottom of the cavity column 35 are larger than the apertures of the hollow plate 1 29 and the hollow plate 2 31 .

[0041] Detailed usage and effects of this embodiment:

[0042] When the filler enters the upper connecting column 9 from the feeding end 3, it is transported downward along the blanking channel formed inside the upper connecting column 9, the guide drum 10, and the bottom connecting cylinder 12. During the transportation process, the rotating end block 19 is driven. When the rotating end block 19 rotates, the inner wall gear 20 of the inner wall of the rotating end block 19 carries the meshing outer gear sleeve 21. After the outer gear sleeve 21 rotates, it will drive the upper connecting column 9 inserted in the middle. The upper connecting column 9 drives the guide drum 10 connected to the bottom. After the guide drum 10 rotates, the guide groove 11 on the upper side will drive the internal matching limit rod 14, and the limit rod 14 will slide along the track of the guide groove 11, thereby causing the outer lifting column 13 to move up and down. When the guide drum 10 rotates, the filler flowing inside will generate centrifugal motion with the rotation, increasing the blanking speed, and carrying the filler into the metering hole 27 below. Under the influence of the metering hole 27, the quantity control effect is achieved. As a result, when the outer lifting column 13 is lifted and lowered, it presses the metering plate mechanism 7 downward together, and the metering plate mechanism 7 hits the hollow plate 1 29. After the metering plate 26 and the metering bottom plate 25 are vibrated, the filler in the metering hole 27 will be filled downward under the action of the vibration. At the same time, when the guide drum 10 rotates, the bottom connecting drum 12 connected to the bottom is driven to rotate together. After the bottom connecting drum 12 rotates, the guide groove 2 34 on the inner wall will carry the internal sliding limit column 33, and the limit column 33 will rise and fall along the trajectory of the guide groove 2 34. At this time, the inner lifting column 30 will move up and down inside the outer drum 28. After the inner lifting column 30 moves up and down, it will continuously hit the cavity column 35. After the cavity column 35 is subjected to the up and down impact movement, the rubber balls 38 connected at the bottom will collide with each other and continuously hit the inner wall of the chromatographic column body 1. After the inner wall is hit, the filler falling inside will be compacted under the vibration.

[0043] The above specific embodiments will allow those skilled in the art to easily implement the present invention. However, it should be understood that the present invention is not limited to the above specific embodiments. Based on the disclosed embodiments, those skilled in the art can arbitrarily combine different technical features to implement different technical solutions.

Claims

1. A chromatographic column filling device, characterized in that It comprises a chromatographic column body (1) and a support base (2), wherein the top of the chromatographic column body (1) is provided with a feed end (3), the bottom of the chromatographic column body (1) is provided with a discharge end (4), and a valve is provided on the discharge end (4); The chromatographic column body (1) is provided with a power mechanism (5), a Y-axis mechanism (6), a metering plate mechanism (7) and a stacking mechanism (8); The power mechanism (5) is connected to the Y-axis mechanism (6), the Y-axis mechanism (6) is connected to the lamination mechanism (8), and the metering plate mechanism (7) is arranged on the Y-axis mechanism (6); The Y-axis mechanism (6) includes an upper connecting column (9), which is connected to the power mechanism (5), a guide rotating cylinder (10) is provided at the bottom of the upper connecting column (9), a guide groove (11) is provided on the upper surface of the guide rotating cylinder (10), a bottom connecting cylinder (12) is provided at the bottom of the guide rotating cylinder (10), an outer lifting column (13) is provided on the outer side of the guide rotating cylinder (10), and limiting rods (14) are provided on both sides of the upper portion of the outer lifting column (13), the inner end of the limiting rod (14) is located in the guide groove (11), a lower connecting column (15) is provided at the bottom of the outer lifting column (13), the lower connecting column (15) is connected to the metering plate mechanism (7), the bottom connecting cylinder (12) passes through the lower connecting column (15), and the bottom connecting cylinder (12) is connected to the stacking mechanism (8); The chromatographic column body (1) is provided with a first buffer block (16), the bottom of the first buffer block (16) is located on the chromatographic column body (1), and a second buffer block (17) is provided on the chromatographic column body (1). The lower part of the chromatographic column body (1) is provided with a third buffer block (18), and the bracket seat (2) is fixed on the third buffer block (18). The stacking mechanism (8) includes an outer rotating cylinder (28), the top of the outer rotating cylinder (28) is provided with a hollow plate 1 (29), the top of the hollow plate 1 (29) is connected to the bottom of the bottom connecting cylinder (12), the inner lifting column (30) is provided with a hollow plate 2 (31) on the top of the inner lifting column (30), and the top of the hollow plate 2 (31) is connected to the bottom of the bottom connecting cylinder (12). A return spring (32) is provided at the center of the inner part, and the top of the return spring (32) is fixed at the bottom center of the hollow plate (29); a plurality of limit columns (33) are provided on the upper surface of the inner lifting column (30), and a guide groove (34) is provided on the inner wall of the outer rotating cylinder (28) to match the limit columns (33). A cavity column (35) is provided at the lower part of the third buffer block (18), and a plurality of discharge holes (36) are provided at the top and bottom of the cavity column (35), and the lower discharge hole (36) corresponds to the upper discharge hole (36). A plurality of ropes (37) are provided at the bottom of the cavity column (35), and a rubber ball (38) is provided at the bottom of the rope (37).

2. A chromatographic column filling device according to claim 1, characterized in that, The power mechanism (5) is arranged at the feed end (3), and the power mechanism (5) includes a rotating end block (19), the rotating end block (19) is embedded in the inner wall of the first buffer block (16), the inner wall gear teeth (20) are provided inside the rotating end block (19), and the upper part of the upper connecting column (9) is provided with an outer gear sleeve (21) meshing with the inner wall gear teeth (20).

3. A chromatographic column filling device according to claim 1, characterized in that, An inner groove (22) is provided on the inner wall of the second buffer block (17), and matching sliders (23) are provided on corresponding two sides of the inner groove (22). The side of the slider (23) away from the inner groove (22) is fixed on the side of the corresponding limit rod (14).

4. A chromatographic column filling device according to claim 1, characterized in that, A through-connected blanking channel is provided inside the upper connecting column (9), the guide rotating cylinder (10), and the bottom connecting cylinder (12), and the bottom connecting cylinder (12) passes through the metering plate mechanism (7).

5. A chromatographic column filling device according to claim 1, characterized in that, The metering plate mechanism (7) includes a metering plate (26), a material blocking plate (24) is provided on the side of the metering plate (26), a metering base plate (25) is provided at the bottom of the material blocking plate (24), and a plurality of metering holes (27) are provided on both the metering plate (26) and the metering base plate (25), and the metering holes (27) are located inside the bottom connecting cylinder (12).

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