Blood coagulation analyzer

Abstract

The invention discloses a blood coagulation analyzer which is characterized in that a reagent adding assembly is used for adding a reagent into a reaction cup at least containing a blood sample; the incubation assembly comprises a plurality of incubation bins and heaters arranged corresponding to the incubation bins, the incubation bins are used for placing reaction cups containing blood samples and reagents, and the heaters are used for heating the reaction cups to execute incubation actions; the first detection assembly and the second detection assembly respectively comprise a plurality of detection positions and optical detection elements, and the optical detection elements detect detection signals for analysis from the detection samples placed on the detection positions based on detection requirements of corresponding detection methodology; the transferring assembly is used for transferring the reaction cups at least partially placed in the incubation bin to a detection position; and a processor for analyzing the blood sample based on the detection signal. By adopting the blood coagulation analyzer, the problems that the blood coagulation analyzer is complex in structure and low in detection efficiency, and the channel difference exists between different fixed detection positions are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of coagulation analysis, and particularly to a coagulation analyzer. Background Art

[0002] The coagulation test items include three methodologies, namely the clotting method, the immunoturbidimetry method, and the colorimetric method. Based on the reaction principle, the immunoturbidimetry method and the colorimetric method usually adopt optical technical means to implement the three tests of the clotting method, the immunoturbidimetry method, and the colorimetric method.

[0003] In the prior art, common coagulation analyzers have low requirements for test efficiency. They usually include multiple fixed detection positions, and each fixed detection position is used to implement at least one coagulation test method. Usually, the fixed detection positions need to continuously detect multiple samples, and some of the detection items corresponding to the samples take a long time, so that some detection items need to wait for a long time to be detected, resulting in low detection efficiency. Therefore, only by increasing the number of fixed detection positions can the detection requirements be met. However, each fixed detection position needs to be configured with relevant components for optical detection corresponding to one or more coagulation test methods, which leads to a complex structure of the coagulation analyzer and the problem that there are differences in the detection components between different fixed detection positions, which may affect the detection results. Summary of the Invention

[0004] The embodiments of the present application provide a coagulation analyzer, and the solution of the present application solves the problems of high design difficulty, low detection efficiency, and channel differences in different fixed detection positions of the coagulation analyzer.

[0005] In a first aspect, an embodiment of the present application provides a coagulation analyzer, including a processor, a reagent adding component, an incubation component, a first detection component, a second detection component, and a transfer component; the reagent adding component is configured to add a reagent into a reaction cup containing at least a blood sample; the incubation component includes a plurality of incubation chambers and heaters provided corresponding to the incubation chambers, the incubation chambers are used to place the reaction cups containing the blood sample and the reagent, and the heaters are used to heat the reaction cups to perform an incubation action; the first detection component includes a plurality of first detection positions and a first optical detection element, wherein the first detection positions are used to place the reaction cups containing a first detection sample formulated from the blood sample and the reagent, and the first optical detection element detects a first detection signal for analysis from the first detection sample based on the detection requirements of the first detection methodology; the second detection component includes a plurality of second detection positions and a second optical detection element, wherein the second detection positions are used to place the reaction cups containing a second detection sample formulated from the blood sample and the reagent, and the second optical detection element detects a second detection signal for analysis from the second detection sample based on the detection requirements of the second detection methodology; the transfer component is configured to transfer at least some of the reaction cups placed in the incubation chambers to the first detection position or the second detection position; the processor analyzes the blood sample based on the first detection signal and the second detection signal respectively; wherein, there is relative movement between the first detection position and the first optical detection element, and / or there is relative movement between the second detection position and the second optical detection element.

[0006] It can be seen that in the embodiment of the present application, through the decoupled design of the detection components based on different detection methodologies, the first detection component and the second detection component are independently provided in the coagulation analyzer for respectively performing sample tests of the first detection methodology and the second detection methodology, reducing the detection design difficulty of the coagulation analyzer, improving the design flexibility, and being beneficial to improving the overall detection efficiency of multiple detection items; at the same time, there is relative movement between the detection positions and the optical detection elements in the first detection component and / or the second detection component, which is beneficial to eliminating channel differences and simplifying the structure.

[0007] Combined with the first aspect, in a possible embodiment, the coagulation analyzer further includes a third detection component, the third detection component includes a plurality of third detection positions and a third optical detection element, wherein the third detection positions are used to place the reaction cups containing a third detection sample formulated from the blood sample and the reagent, and the third optical detection element detects a third detection signal for analysis from the third detection sample based on the detection requirements of the third detection methodology; the transfer component is further configured to transfer at least some of the reaction cups placed in the incubation chambers to the third detection position; the processor further analyzes the blood sample based on the third detection signal.

[0008] In combination with the first aspect, in a possible embodiment, the second detection position is further used to place a reaction cup for containing a third detection sample prepared from a blood sample and a reagent, and the second optical detection element is further based on the detection requirements of the third detection methodology to detect a third detection signal for analysis from the third detection sample; the processor is further based on the third detection signal to perform analysis of the blood sample.

[0009] In combination with the first aspect, in a possible embodiment, the first optical detection element is based on the detection requirements of the first detection methodology and detects a first detection signal for analysis from the first detection sample at a first detection frequency; the second optical detection element is based on the detection requirements of the second detection methodology and detects a second detection signal for analysis from the second detection sample at a second detection frequency; wherein, the first detection frequency is greater than the second detection frequency.

[0010] It can be seen that in the embodiments of the present application, based on the different detection frequencies, the unified detection component is decoupled into different first detection components and second detection components, and only the corresponding detection efficiency needs to be followed for detection in the first detection component and the second detection component, thereby reducing the design difficulty of the coagulation analyzer and improving the overall detection efficiency of multiple detection items.

[0011] In combination with the first aspect, in a possible embodiment, the second detection component is arranged in the incubation component; the second detection position is multiplexed with at least part of the incubation chamber, the second optical detection element includes a second light source and a second optical detector, and the second light source and the second optical detector are arranged at relatively spaced intervals with respect to the multiplexed incubation chamber; wherein the multiplexed incubation chamber is only used for detection, or is used for incubation and detection at the same time; when the multiplexed incubation chamber passes through the emission area of the second light source, the emission light emitted by the second light source, after passing through the reaction cup placed in the multiplexed incubation chamber, is received by the second optical detector, thereby detecting a second detection signal or a third detection signal for analysis, wherein the multiplexed incubation chamber enters the emission area of the second light source according to a preset rotation period.

[0012] In combination with the first aspect, in a possible embodiment, the incubation component includes a support, both the second light source and the second optical detector are arranged on the support, and the multiplexed incubation chamber is provided with a first optical window and a second optical window; when the multiplexed incubation chamber passes through the emission area of the second light source, the emission light emitted by the second light source first enters the multiplexed incubation chamber through the first optical window, and then after passing through the reaction cup placed in the multiplexed incubation chamber, passes through the second optical window and is received by the second optical detector, thereby detecting a second detection signal or a third detection signal for analysis.

[0013] It can be seen that in the embodiments of the present application, by arranging the second detection component in the incubation component, it is beneficial to simplify the structure of the coagulation analyzer for the samples that need to be detected by the second detection component.

[0014] In combination with the first aspect, in a possible embodiment, the first detection component includes a first detection disk or a first detection track, and a first detection position is arranged in the first detection disk or the first detection track; the first optical detection element includes a first light source and a first optical detector, and the first light source and the first optical detector are arranged at intervals with respect to the first detection position; wherein, the first detection position enters the emission area of the first light source according to a preset moving period or rotation period; when the first detection position passes through the emission area of the first light source, the emission light emitted by the first light source, after passing through the reaction cup placed in the first detection position, is received by the first optical detector, so as to detect a first detection signal for analysis.

[0015] In combination with the first aspect, in a possible embodiment, the second detection component includes a second detection disk or a second detection track, and a second detection position is arranged in the second detection disk or the second detection track; the second optical detection element includes a second light source and a second optical detector, and the second light source and the second optical detector are arranged at intervals with respect to the second detection position; wherein, the second detection position enters the emission area of the second light source according to a preset moving period or rotation period; when the second detection position passes through the emission area of the second light source, the emission light emitted by the second light source, after passing through the reaction cup placed in the second detection position, is received by the second optical detector, so as to detect a second detection signal or a third detection signal for analysis.

[0016] In combination with the first aspect, in a possible embodiment, the first light source or the second light source is a multi-wavelength coupled light source; the emission light emitted by the multi-wavelength coupled light source is split after passing through the reaction cup, and the optical signals of each optical path after splitting are received by at least one optical detector, and the optical signals of at least part of the optical paths are detection signals for analysis.

[0017] It can be seen that in the embodiment of the present application, by using a multi-wavelength coupled light source to detect the sample, only one light source needs to be arranged in the detection component to realize the detection of the detection items corresponding to various detection methodologies, saving the optical elements required by the coagulation analyzer and simplifying the overall architecture of the coagulation analyzer.

[0018] In combination with the first aspect, in a possible embodiment, the first light source or the second light source is a single-wavelength light source; the emission light emitted by the single-wavelength light source is received by the optical detector after passing through the reaction cup, so as to detect a detection signal for analysis.

[0019] It can be seen that in the embodiment of the present application, by using a single-wavelength light source with a lower cost to detect the sample, the production cost of the coagulation analyzer is saved. Description of the Drawings

[0020] To more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the accompanying drawings required for the description of the embodiments. Obviously, the accompanying drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other accompanying drawings can be obtained based on these drawings.

[0021] Figure 1 It is a schematic structural diagram of a coagulation analyzer provided by an embodiment of the present application;

[0022] Figure 2 It is an example diagram of the detection task flow of a single reagent detection item and a double reagent detection item provided by an embodiment of the present application;

[0023] Figure 3 It is a schematic structural diagram of a second detection disk provided by an embodiment of the present application;

[0024] Figure 4A It is a schematic structural diagram of a second detection track provided by an embodiment of the present application;

[0025] Figure 4B It is a schematic structural diagram of another second detection track provided by an embodiment of the present application;

[0026] Figure 5 It is a schematic structural diagram of another coagulation analyzer provided by an embodiment of the present application;

[0027] Figure 6 It is a schematic diagram of the test process of a reusable incubation chamber provided by an embodiment of the present application;

[0028] Figure 7 It is a schematic structural diagram of yet another coagulation analyzer provided by an embodiment of the present application. Detailed implementation manners

[0029] To enable those skilled in the art to better understand the solutions of the present application, the following will clearly and completely describe the technical solutions in the embodiments of the present application in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, rather than all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope protected by the present application.

[0030] In the description, claims and the above-mentioned drawings of this application, terms such as "first", "second", etc. are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "comprising" and "having" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally further includes steps or units not listed, or optionally further includes other steps or units inherent to these processes, methods, products or devices.

[0031] Reference to "embodiment" herein means that a particular feature, structure or characteristic described in connection with the embodiment can be included in at least one embodiment of this application. The phrase appears in various places in the specification and does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0032] As used herein, the "coagulation method" refers to a method of simulating the coagulation conditions of physiological blood, adding specific reagents, initiating the blood agglutination reaction, converting fibrinogen in the suspected sample into cross-linked fibrin, and causing the test sample to coagulate. By continuously monitoring the changes in optical (such as absorbance), physical (such as viscosity), or electrical (such as current) characteristics of the reaction system during this process to determine the end point of the reaction, and using this as the conversion time of fibrinogen, a method for measuring the coagulation characteristics or fibrinolysis characteristics of a blood sample using this principle.

[0033] As used herein, the "colorimetric method", also known as the chromogenic substrate method, refers to a method in which an artificially synthesized compound with a specific cleavage site (such as phenylalanine-valine-arginine amide, Phe-Val-Arg) is combined with a chromogenic substance (such as p-nitroaniline - PNA) to form a specific substrate of an enzyme. Due to the presence or generation of an active enzyme in the test sample, the substrate is hydrolyzed and the chromogenic substance is released, causing a color change in the reaction system. The degree of color change is detected by colorimetry and is in a certain proportional relationship with the enzyme activity or the content of the test sample.

[0034] As used herein, the "immunoturbidimetry" refers to a method of using the specific binding characteristic between an antigen and an antibody, causing the test sample to bind to microparticles labeled with its specific antibody, resulting in a change in the turbidity of the reaction system, and quantitatively determining the test sample by detecting the change in its light intensity.

[0035] The embodiments of this application will be described below with reference to the drawings.

[0036] Please refer to Figure 1 , Figure 1A schematic structural diagram of a coagulation analyzer provided by an embodiment of the present application. The coagulation analyzer 100 therein includes a processor 101, a reagent adding assembly 102, an incubation assembly 103, a first detection assembly 104, a second detection assembly 105, and a transfer assembly 106.

[0037] The processor 101 is connected to the reagent adding assembly 102, the incubation assembly 103, the first detection assembly 104, the second detection assembly 105, and the transfer assembly 106. The processor 101 controls each component in the coagulation analyzer 100 to perform steps such as adding reagents, incubating, detecting, and transferring on the sample to achieve the analysis of the sample.

[0038] Optionally, if a microcontroller is built in each component, each component in the coagulation analyzer 100 controls the operation of each component through the microcontroller.

[0039] Among them, the reagent adding assembly 102 is used to add reagents into the reaction cup containing at least a blood sample. Specifically, the blood sample here specifically includes plasma and / or serum, and the reagent adding assembly will add one or more reagents into the reaction cup containing the blood sample according to the detection methodology corresponding to the detection item.

[0040] The type of reagent and the reagent adding order correspond to one of the clotting method, immunoturbidimetry, and colorimetry. That is to say, for detection items with different detection methodologies, different reagents need to be added, and the quantity or order of adding reagents may also be different. For example, the reagent adding assembly 102 can add the first reagent into the reaction cup containing only the blood sample; it can also add a new reagent into the reaction cup containing the blood sample and the reagent.

[0041] The incubation assembly 103 includes several incubation chambers and heaters provided corresponding to the incubation chambers. The incubation chambers are used to place the reaction cups containing at least the blood sample, and the heaters are used to heat the reaction cups placed in the incubation chambers to perform incubation operations on the blood samples or the blood samples added with reagents in the reaction cups.

[0042] Specifically, during the coagulation analysis process, the heaters in the incubation assembly 103 are required to simulate the physiological environment for the sample, eliminate interference factors, and standardize the reaction conditions to ensure the accuracy and reliability of the coagulation detection results. For samples corresponding to different detection methodologies, the incubation assembly 103 also incubates the blood samples according to different temperatures and heating durations.

[0043] Generally, after adding a blood sample to the reaction cup, it will be placed in the incubation component 103, and the incubation component 103 will incubate the reaction cup. After incubation, the reagent addition component 102 will add the first reagent to the reaction cup again; if no more reagents need to be added subsequently, the sample in the reaction cup can be directly detected at this time; if more reagents need to be added, the incubation component 103 will perform a second incubation on the reaction cup after adding the first reagent, and so on. Until all reagents are added and the test sample preparation is completed, the reaction cup can then be transferred to the detection component for detection.

[0044] Exemplarily, please refer to Figure 2 , Figure 2 which is an example diagram of the detection task flow for a single-reagent detection item and a double-reagent detection item provided by an embodiment of the present application. As Figure 2 shown, a single single-reagent detection item includes five action links: sample addition, incubation, addition of the first reagent (shown as adding R1 in the figure), detection, and cup discarding. As Figure 2 shown, a single double-reagent detection item includes seven action links: sample addition, first incubation, addition of the first reagent (shown as adding R1 in the figure), second incubation, addition of the second reagent (shown as adding R2 in the figure), detection, and cup discarding.

[0045] Furthermore, the coagulation analyzer 100 further includes a mixing component for mixing the blood sample and the reagent in the reaction cup. In some embodiments, the mixing component is configured near the reagent addition component 102 to promptly mix the blood sample and the reagent in the reaction cup after adding the reagent.

[0046] The first detection component 104 includes a plurality of first detection positions and a first optical detection element, where the first detection positions are used to place reaction cups containing the first detection samples formulated from the blood sample and the reagent, and the first optical detection element detects a first detection signal for analysis from the first detection sample based on the detection requirements of the first detection methodology.

[0047] Specifically, the first detection positions in the first detection component 104 are used to place the first detection samples corresponding to the first detection methodology, and the first detection samples are blood samples that have been added with the corresponding reagents and incubated and are corresponding to the first detection methodology.

[0048] Since the three detection methodologies for coagulation detection, the clotting method, the immunoturbidimetry method, and the colorimetric method, all use optical methods to detect samples. Therefore, a first optical detection element is configured in the first detection component 104.

[0049] The first optical detection element is used to detect the first detection sample placed at the first detection position based on the detection requirements of the first detection methodology, and obtain the first detection signal for analysis. The first detection methodology here is the coagulation method, immunoturbidimetry, or colorimetry.

[0050] In some embodiments, the first detection position further includes a heater for maintaining a constant temperature for the first detection sample when detecting the first detection sample.

[0051] The second detection component 105 includes a plurality of second detection positions and a second optical detection element. The second detection positions are used to place reaction cups containing the second detection samples prepared from blood samples and reagents. The second optical detection element detects the second detection signal for analysis from the second detection samples based on the detection requirements of the second detection methodology.

[0052] Specifically, the second detection component 105 includes a plurality of second detection positions and a second optical detection element.

[0053] The second detection positions are used to place the second detection samples corresponding to the second detection methodology. The second detection samples are blood samples that have been added with the corresponding reagents and incubated and are corresponding to the second detection methodology.

[0054] The second optical detection element is used to detect the second detection sample placed at the second detection position based on the detection requirements of the second detection methodology, and obtain the second detection signal for analysis. The second detection methodology here is the coagulation method, immunoturbidimetry, or colorimetry.

[0055] In some embodiments, the second detection position further includes a heater for maintaining a constant temperature for the second detection sample when detecting the second detection sample.

[0056] The first detection component 104 and the second detection component 105 here are respectively used to detect samples corresponding to different detection methodologies. In some embodiments, they are divided based on the detection frequency. For example, the first detection component 104 is used to detect samples corresponding to the coagulation method, while the second detection component 105 is used to detect samples corresponding to immunoturbidimetry. For example, the first detection component 104 is used to detect samples corresponding to the coagulation method, while the second detection component 105 is used to detect samples corresponding to colorimetry.

[0057] In some embodiments, the second detection position is further used to place reaction cups containing the third detection samples prepared from blood samples and reagents. The second optical detection element also detects the third detection signal for analysis from the third detection samples based on the detection requirements of the third detection methodology; the processor also analyzes the blood samples based on the third detection signal.

[0058] Specifically, in the embodiment of the present application, the second optical detection element is used to detect samples corresponding to the second detection methodology and the third detection methodology.

[0059] In some embodiments, the first detection methodology is coagulation method, the second detection methodology is immunoturbidimetry, and the third detection methodology is colorimetry. That is, the first detection component is used to detect blood samples corresponding to coagulation method; the second detection component is used to detect blood samples corresponding to immunoturbidimetry and colorimetry.

[0060] In some embodiments, the first optical detection element detects a first detection signal for analysis from a first detection sample at a first detection frequency based on the detection requirements of a first detection methodology; the second optical detection element detects a second detection signal for analysis from a second detection sample at a second detection frequency based on the detection requirements of a second detection methodology; wherein the first detection frequency is greater than the second detection frequency.

[0061] Specifically, in the embodiment of the present application, the first detection methodology is coagulation method, and the second detection methodology is immunoturbidimetry or colorimetry. This is because the detection frequency of coagulation method is much higher than the detection frequency of immunoturbidimetry and colorimetry, therefore, the detection items of coagulation method are implemented by the first detection component alone, while the detection frequencies of immunoturbidimetry and colorimetry are close, and both can be implemented by the second detection component, which is conducive to improving the overall detection efficiency, while also taking into account the need for simplified structural design.

[0062] It should be noted that in the coagulation method, immunoturbidimetry and colorimetry, there are different requirements for the frequency of obtaining the detection signal.

[0063] Among them, for the coagulation method, a higher detection frequency is required in the specific detection process; for example, the interval for each data collection is 100ms, or even lower.

[0064] In the detection process of immunoturbidimetry and colorimetry, an excessively high detection frequency is not required; for example, the interval between each data collection is several seconds or even tens of seconds.

[0065] Therefore, based on the detection requirements of the first detection methodology (ie, the coagulation method), the first optical detection element detects a first detection signal for analysis from the first detection sample corresponding to the first detection methodology at a first detection frequency.

[0066] Based on the detection requirements of the second detection methodology (i.e., immunoturbidimetry or colorimetry), the second optical detection element detects a second detection signal for analysis from a second detection sample corresponding to the second detection methodology at a second detection frequency, thereby enabling the processor 101 to analyze the coagulation ability and other related properties of the blood sample based on the second detection signal.

[0067] The second optical detection element also detects a third detection signal for analysis from a third detection sample corresponding to the colorimetric method (the third detection methodology in this example) based on the detection requirements of the colorimetric method, so that the processor 101 can analyze relevant properties such as the blood coagulation ability of the blood sample according to the third detection signal here.

[0068] It should be noted that the requirements for the detection frequency of immunoturbidimetry and colorimetry are relatively close (for example, the interval for collecting data each time described throughout the text is several seconds or even dozens of seconds, which can meet the requirements). Therefore, the detection items of the two detection methodologies can be integrated into the same detection component. The second detection frequency and the third detection frequency here are specifically the same value, the second detection frequency is an integer multiple of the third detection frequency, or the third detection frequency is an integer multiple of the second detection frequency.

[0069] In addition, the second detection sample and the third detection sample corresponding to the second detection methodology and the third detection methodology can also be detected in different detection components respectively, that is, the second detection sample is detected in the second detection component 105, and the third detection sample is detected in the third detection group.

[0070] The detection frequency mentioned in the text specifically refers to the frequency of collecting detection signals, that is, the number of times of collecting signals per unit time.

[0071] It can be seen that in the embodiment of the present application, based on different detection frequencies, the unified detection component is decoupled into different first detection components and second detection components. The first detection component and the second detection component only need to perform detections according to the corresponding detection efficiencies, thereby reducing the design difficulty of the coagulation analyzer and improving the overall detection efficiency of multiple detection items.

[0072] In addition, the first detection position in the first detection component 104 and the first optical detection element are relatively movable, and / or the second detection position in the second detection component 105 and the second optical detection element are relatively movable.

[0073] Specifically, in the first detection component 104 and the second detection component 105, at least one of the detection positions of the detection component and the optical detection element is relatively movable.

[0074] For the detection component where the detection position and the optical detection element are relatively movable, it specifically includes the case where the detection position is fixed and the corresponding optical detection element can move; or the optical detection element is fixed and the corresponding several detection positions can move; or both the optical detection element and several detection positions can move, etc.

[0075] Among them, if the detection positions are fixed and the corresponding optical detection elements can move, the detection assembly can detect the test samples at each detection position according to the detection frequency required by the corresponding detection methodology by moving the optical detection elements, so that it is not necessary to configure an optical detection element for each detection position in the coagulation analyzer.

[0076] If the optical detection elements are fixed, several corresponding detection positions can move. By moving the several corresponding detection positions, it is also possible to make the several detection positions sequentially enter the detection range of the optical detection elements in a cycle according to a preset speed, so that the optical detection elements detect the test samples at each detection position according to the detection frequency required by the corresponding detection methodology. It is not necessary to configure an optical detection element for each detection position.

[0077] If both the optical detection elements and several detection positions can move, it is possible to make the several detection positions sequentially enter the detection range of the optical detection elements in a cycle according to a preset speed by moving the several detection positions and / or the optical detection positions, so as to achieve detecting the test samples at each detection position according to the detection frequency required by the corresponding detection methodology.

[0078] It can be seen from the above three different configurations of relative movement between the optical detection elements and several detection positions that only one detection light source is needed in the detection assembly to detect all the test samples at several detection positions, which can not only eliminate the problem of channel difference caused by configuring multiple optical detection elements to detect different test samples, but also simplify the structure and save costs.

[0079] At the same time, several detection positions can also sequentially enter the operation ranges of components such as the reagent adding assembly 102 and the transfer assembly 106 in a cycle according to a preset moving speed, thereby reducing the operation distances of the reagent adding assembly 102 and the transfer assembly 106 during reagent addition or sample transfer. The reagent adding assembly 102 and the transfer assembly 106 only need to operate within a relatively short distance to achieve operations such as sample addition and transfer of the test samples, improving the detection efficiency of the coagulation analyzer.

[0080] In addition, it should be noted that if there is relative movement between the detection positions and the optical detection elements. The optical detection elements in the corresponding detection assembly need to be configured with a fixed detection light source and an optical detector for each detection position to detect the test samples at each detection position.

[0081] The transfer assembly 106 is used to transfer at least part of the reaction cups placed in the incubation chamber to the detection positions.

[0082] In some embodiments, the transfer assembly 106 is configured to transfer at least a part of the reaction cups placed in the incubation chamber to the first detection position or the second detection position, so that the first detection assembly 104 and the second detection assembly 105 can respectively detect the test samples in the reaction cups placed at the first detection position and the second detection position.

[0083] Further, the transfer assembly 106 is also configured to transfer the reaction cups to the sample addition position for sample addition; further, the transfer assembly 106 is also configured to transfer the reaction cups after sample addition or reagent addition to the incubation chamber for incubation; further, the transfer assembly 106 is also configured to transfer the reaction cups in the incubation chamber to the reagent addition position for reagent addition. In some embodiments, the transfer assembly 106 may include a plurality of grippers for performing transfer actions for different purposes respectively or at least taking into account multiple purposes; in some embodiments, when meeting the scheduling requirements, the transfer assembly 106 may also include only one gripper, and the same gripper is used to perform the transfer actions for the above purposes.

[0084] In some embodiments, the coagulation analyzer 100 further includes a reaction cup tray for placing empty reaction cups, and a sample addition assembly for adding blood samples to the empty reaction cups. The coagulation analyzer 100 further includes a first loading and unloading position, a first reagent addition position, a second loading and unloading position, and a second reagent addition position.

[0085] Exemplarily, in a detection process including steps such as sample addition, reagent addition, and incubation, the coagulation analyzer 100 specifically needs to perform the following steps:

[0086] Step 1: The transfer assembly 106 transfers the reaction cups from the reaction cup tray to the first loading and unloading position.

[0087] Step 2: The reaction cups are moved from the first loading and unloading position to the sample addition position, and the sample addition assembly adds blood samples to the reaction cups at the sample addition position.

[0088] Step 3: The transfer assembly 106 transfers the reaction cups from the sample addition position to the incubation chamber of the incubation assembly 103, so that the incubation assembly 103 performs the first incubation on the reaction cups.

[0089] Step 4: After the first incubation is completed, the transfer assembly 106 moves the reaction cups to the first reagent addition position, so that the reagent addition assembly 102 adds the first reagent to the reaction cups.

[0090] Step 5: The reaction cups are moved from the first reagent addition position to the second loading and unloading position.

[0091] Step 6: The transfer assembly 106 transfers the reaction cups with blood samples and reagents added at the second loading and unloading position to the mixing mechanism for mixing.

[0092] Step 7: If no other reagents need to be added, the transfer assembly 106 transfers the reaction cup to the first detection assembly 104 or the second detection assembly 105 for detection.

[0093] Step 8: If other reagents still need to be added, the transfer assembly 106 moves the reaction cup from the sample addition position to the incubation chamber of the incubation assembly 103, so that the incubation assembly 103 performs a second incubation on the reaction cup.

[0094] Step 9: After the second incubation is completed, the transfer assembly 106 transfers the reaction cup to the second reagent position. After the reagent addition assembly 102 adds the second reagent to the reaction cup, it is necessary to mix the reaction cup again (if more reagents need to be added after the second reagent addition, it is necessary to perform an incubation action again before adding the reagent). After all the reagents are added, the transfer assembly 106 transfers the incubated reaction cup to the first detection assembly 104 or the second detection assembly 105 for detection).

[0095] Step 10: After the detection is completed, the transfer assembly 106 performs a cup discarding process on the detected reaction cup.

[0096] It should be noted that when multiple blood samples need to be detected, the coagulation analyzer adds samples, reagents, transfers, incubates, detects, etc. according to the execution order and execution time preset for the detection methodology corresponding to each blood sample to implement the aforementioned Steps 1 - 10.

[0097] The processor 101 is configured to analyze the blood sample at least based on the first detection signal and the second detection signal.

[0098] In some embodiments, the processor 101 respectively obtains a plurality of data from the first detection signal and the second detection signal. Here, the first detection signal and the second detection signal are optical signals respectively detected by the first optical detection element and the second optical detection element according to the detection frequencies required by their respective corresponding detection methodologies. The processor also extracts the data to be used from different signals based on the requirements of the detection methodologies corresponding to different detection signals, so as to obtain the detection results of the detection samples corresponding to different detection methodologies.

[0099] Exemplarily, in the detection process corresponding to the immunocolorimetry method, the processor 101 obtains the data to be used from the optical signal of the corresponding detection sample, and then infers the change situation of the absorbance of the detection sample, and obtains the detection result of the corresponding detection sample according to the change situation of the absorbance of the detection sample.

[0100] During the detection process of the coagulation method, the processor 101 obtains the data to be used from the optical signals of the corresponding detection samples, and then infers the coagulation time of the detection samples, and obtains the detection results of the corresponding detection samples according to the coagulation time.

[0101] In some embodiments, the coagulation analyzer 100 further includes a third detection component. The third detection component includes a plurality of third detection positions and a third optical detection element. The third detection positions are used to place reaction cups containing third detection samples formulated from blood samples and reagents. The third optical detection element detects third detection signals available for analysis from the third detection samples based on the detection requirements of the third detection methodology; the transfer component is further configured to transfer at least some of the reaction cups placed in the incubation chamber to the third detection positions; the processor is further configured to analyze the blood samples based on the third detection signals.

[0102] Specifically, the third detection component is similar to the first detection component and the second detection component, and includes a plurality of third detection positions and a third optical detection element. For the relevant description of the detection process of the third detection sample, please refer to the relevant descriptions of the first detection sample and the second detection sample above, and will not be repeated here.

[0103] In some embodiments, the processor 101 respectively obtains a plurality of data from the first detection signal, the second detection signal, and the third detection signal. Here, the first detection signal, the second detection signal, and the third detection signal are optical signals respectively detected by the first optical detection element, the second optical detection element, and the third optical detection element according to the detection frequencies required by their respective corresponding detection methodologies. The processor also extracts the data to be used from different signals based on the requirements of the detection methodologies corresponding to different detection signals, so as to obtain the detection results of the detection samples corresponding to different detection methodologies.

[0104] Exemplarily, during the detection process corresponding to the turbidimetry method, the processor 101 obtains the data to be used from the optical signals of the corresponding detection samples, and then infers the change in the absorbance of the detection samples, and obtains the detection results of the corresponding detection samples according to the change in the absorbance of the detection samples.

[0105] In the embodiments of the present application, each detection component corresponds to a detection methodology. Exemplarily, for example, the first detection component is used to detect blood samples corresponding to the coagulation method; the second detection component is used to detect blood samples corresponding to the immunoturbidimetry method; the third detection component is used to detect blood samples corresponding to the colorimetry method.

[0106] In some embodiments, the third detection position and the third optical detection element are fixed.

[0107] In some other embodiments, there is relative movement between the third detection position and the third optical detection element, which is conducive to simplifying the structure and reducing costs. For example, the third detection position is fixed, and the corresponding third optical detection element can move. For example, the third optical detection element is fixed, and several corresponding third detection positions can move. For example, both the third optical detection element and several third detection positions can move, etc. For a detailed description of the relatively moving third detection position and third optical detection element, please refer to the relevant descriptions of the relatively moving first detection position and first optical detection element, and the relatively moving second detection position and second optical detection element, which will not be elaborated here.

[0108] In some embodiments, the second detection component includes a second detection disk or a second detection track, and a second detection position is arranged in the second detection disk or the second detection track; the second optical detection element includes a second light source and a second optical detector, and the second light source and the second optical detector are arranged at intervals relative to the second detection position; wherein, the second detection position enters the emission area of the second light source according to a preset moving period or rotation period; when the second detection position passes through the emission area of the second light source, the emission light emitted by the second light source, after passing through the reaction cup placed in the second detection position, is received by the second optical detector, so as to detect a second detection signal or a third detection signal available for analysis.

[0109] Specifically, in the embodiments of the present application, the second detection position is movable and the second optical detection element is fixed. The second detection position moves through the second detection disk or the second detection track, and the second detection position enters the emission area of the second light source according to a preset moving period or rotation period, so as to realize the relative movement between the second detection position and the second optical detection element.

[0110] After the second detection position enters the emission area of the second light source. The emission light emitted by the second light source, after passing through the reaction cup placed in the second detection position, is received by the second optical detector, so as to detect a second detection signal or a third detection signal available for analysis.

[0111] The following content will describe the second detection component including the second detection disk:

[0112] Exemplarily, please refer to Figure 3 , Figure 3 which is a schematic structural diagram of a second detection disk provided by an embodiment of the present application. Among them, the second detection component 105 includes a second detection disk 1051, a second light source 1052, a second optical detector 1053, and a second detection position 1054. The second light source 1052 and the second optical detector 1053 belong to the second optical elements.

[0113] Among them, several second detection positions 1054 are arranged on the second detection disk 1051. For the convenience of description, inFigure 3 In the illustrated example, only five second detection positions 1054 are shown. In an actual second detection disc 1051, more or fewer second detection positions 1054 are provided.

[0114] The second detection disc 1051 is configured to drive the second detection positions 1054 to enter the emission region of the second light source 1052 according to a preset rotation period. When a second detection position 1054 passes through the emission region of the second light source 1052, the emitted light from the second light source 1052, after passing through a reaction cup (including a second detection sample or a third detection sample) placed in the second detection position 1054, is received by the second optical detector 1053, thereby detecting a second detection signal or a third detection signal available for analysis.

[0115] In some embodiments, the second detection disc 1051 rotates at a first speed so that the transfer assembly 106 places a reaction cup in the second detection position 1054 or removes a reaction cup from the second detection position 1054.

[0116] The second detection disc 1051 rotates at a second speed so that a plurality of second detection positions 1054 can enter the emission region of the second light source 1052 according to a preset frequency.

[0117] Specifically, when the transfer assembly 106 needs to place a reaction cup in the second detection position 1054 or transfer a reaction cup from the second detection position 1054, the second detection disc 1051 rotates at the first speed. The first speed here is based on the transfer assembly. If the transfer range of the transfer assembly can cover all the second detection positions 1054, the first speed here can be set to 0.

[0118] The second speed here is determined based on the second detection methodology and the third detection methodology. The second detection disc 1051 rotates at the second speed so that a plurality of second detection positions can enter the emission region of the second light source according to a preset frequency, and the preset frequency here meets the detection frequency requirements of the second detection methodology and the third detection methodology.

[0119] The following content will describe a second detection component including a second detection track:

[0120] Exemplarily, please refer to Figure 4A , Figure 4A which is a schematic structural diagram of a second detection track provided by an embodiment of the present application. Among them, the second detection component 105 includes a second detection track 1055, a second light source 1052, a second optical detector 1053, and a second detection position 1054. The second light source 1052 and the second optical detector 1053 belong to second optical elements.

[0121] It can be seen that the second detection track 1055 moves at a moving speed, which can drive the second detection position 1054 to enter the emission area of the second light source 1052 at a frequency required by the corresponding detection methodology. When the second detection position 1054 passes through the emission area of the second light source 1052, the emission light emitted by the second light source 1052 passes through the reaction cup placed in the second detection position 1054 and is received by the second optical detector 1053, so as to detect the second detection signal or the third detection signal available for analysis according to the corresponding frequency.

[0122] For ease of explanation Figure 4A Only 12 second detection positions 1054 are shown. In actual applications, there may be more or fewer second detection positions 1054.

[0123] Optionally, please refer to Figure 4B , Figure 4B which is a schematic structural diagram of another second detection track provided by an embodiment of the present application. It can be seen that the second detection track 1055 drives the second detection position 1054 to enter the emission areas of multiple second light sources 1052 successively at a predetermined moving speed, so that the detection samples on each second detection position 1054 can be detected at a preset frequency. When the second detection position 1054 enters the emission area of any second light source 1052, the emission light emitted by the second light source 1052 passes through the reaction cup placed in the second detection position 1054 and is then received by the corresponding second optical detector 1053, so as to detect the second detection signal or the third detection signal available for analysis.

[0124] Meanwhile, under this structure, a plurality of second optical detection elements including the second light source 1052 and the second optical detector 1053 need to be arranged on the second detection track 1055 at a preset interval (the two second optical detection elements shown here are only examples) to meet the detection frequency requirements of the second detection methodology or the third detection methodology.

[0125] Figure 4A and Figure 4B the second detection track 1055 shown can also move at a third speed and a fourth speed respectively.

[0126] The second detection track 1055 moves at a third speed so that the transfer assembly 106 places the reaction cup on the second detection position 1054 or removes the reaction cup from the second detection position 1054.

[0127] The second detection track 1055 rotates at a fourth speed so that a plurality of second detection positions 1054 can enter the emission area of the second light source 1052 at a preset frequency.

[0128] For the detailed description of the third speed, please refer to the detailed description of the first speed. For the detailed description of the fourth speed, please refer to the detailed description of the second speed, which will not be elaborated here.

[0129] Optionally, the first detection component includes a first detection disk or a first detection track, and a first detection position is arranged inside the first detection disk or the first detection track; the first optical detection element includes a first light source and a first optical detector, and the first light source and the first optical detector are arranged at intervals relative to the first detection position; wherein, the first detection position enters the emission area of the first light source according to a preset moving period or rotation period; when the first detection position passes through the emission area of the first light source, the emission light emitted by the first light source, after passing through the reaction cup placed in the first detection position, is received by the first optical detector, so as to detect the first detection signal available for analysis.

[0130] Optionally, the third detection component includes a third detection disk or a third detection track, and a third detection position is arranged inside the third detection disk or the third detection track; the third optical detection element includes a third light source and a third optical detector, and the third light source and the third optical detector are arranged at intervals relative to the third detection position; wherein, the third detection position enters the emission area of the third light source according to a preset moving period or rotation period; when the third detection position passes through the emission area of the third light source, the emission light emitted by the third light source, after passing through the reaction cup placed in the third detection position, is received by the third optical detector, so as to detect the third detection signal available for analysis.

[0131] Similar to the internal structure of the second detection component, the first detection component can also include a first detection disk or a first detection track to realize the relative movement of the first detection position and the first optical detection element, and the third detection component can also include a third detection disk or a third detection track to realize the relative movement of the third detection position and the third optical detection element. The operation mode of the first detection disk or the first detection track in the first detection component, the operation mode of the third detection disk or the third detection track in the third detection component and the detailed description please refer to the relevant description of the second detection disk or the second detection track of the second detection component, which will not be elaborated here. In some embodiments, when the detection throughput is satisfied, the first detection position and the first optical detection element in the first detection component are fixed, for example, in a fixed position manner.

[0132] It can be seen that in the embodiments of the present application, through the decoupled design of detection components based on different detection methodologies, the first detection component and the second detection component are independently arranged in the coagulation analyzer for sample testing of the first detection methodology and the second detection methodology respectively, reducing the detection design difficulty of the coagulation analyzer, improving the design flexibility, and being conducive to improving the overall detection efficiency of multiple detection items. At the same time, the detection positions in the first detection component and / or the second detection component are relatively movable with respect to the optical detection elements, which is conducive to eliminating channel differences, simplifying the structure, and reducing costs.

[0133] The above embodiments of the application describe a coagulation analyzer with an independent arrangement between an incubation component and a second detection component. Based on this, on the premise that the second detection component is arranged inside the incubation component, the embodiments of the present application also provide another structure of the coagulation analyzer. Please refer to Figure 5 , Figure 5 FIG. 7 is a schematic structural diagram of another coagulation analyzer provided by the embodiments of the present application, where the coagulation analyzer 500 includes a processor 501, a reagent adding component 502, an incubation component 503, a first detection component 504, a second detection component 505, and a transfer component 506.

[0134] For the detailed description of the processor 501, the reagent adding component 502, the first detection component 504, and the transfer component 506, please refer to Figure 1 the relevant content, which will not be elaborated here.

[0135] Among them, the second detection component 505 is arranged inside the incubation component 503. The second detection component 505 includes a plurality of second detection positions and second optical detection elements, and the second detection positions are multiplexed with at least part of the incubation chambers.

[0136] Among them, the multiplexed incubation chambers are only used for detection, or are used for incubation and detection at the same time. In some embodiments, the incubation component 503 includes at least one multiplexed incubation chamber and ordinary incubation chambers. The multiplexed incubation chambers have both incubation and detection functions, while the ordinary incubation chambers that are not multiplexed with the second detection positions are only used for incubation. When the transfer component transfers the reaction cups for detection, it is necessary to transfer the reaction cups to the multiplexed incubation chambers, and when transferring the reaction cups for incubation, the reaction cups can be transferred to the multiplexed incubation chambers or ordinary incubation chambers. In some embodiments, the incubation component 503 includes ordinary incubation chambers and multiplexed incubation chambers, and the multiplexed incubation chambers are only used for detection. Then, when the transfer component transfers the reaction cups for detection, it is necessary to transfer the reaction cups to the multiplexed incubation chambers inside the incubation component 503, and when transferring the reaction cups for incubation, the reaction cups can be transferred to the ordinary incubation chambers.

[0137] The following will take the example where all the incubation chambers in the incubation tray are reusable incubation chambers, and the reusable incubation chambers are used for incubation and detection simultaneously. The reusable incubation chambers can be used to perform the incubation of blood samples and reagents corresponding to the first detection methodology, the incubation of blood samples and reagents corresponding to the second detection methodology, and can also be used for the detection of the second detection samples. After the incubation is completed on the reusable incubation chamber, the transfer component 506 is required to transfer the first detection sample to the reagent addition position to add and mix the final reagent, and then transfer it to the first detection position of the first detection component 504. After the incubation of the second detection sample is completed on the reusable incubation chamber, the transfer component 506 is required to transfer the second detection sample to the reagent addition position to add and mix the final reagent, and then transfer it back to the reusable incubation chamber of the incubation tray. The second light source and the second optical detector of the second detection component 505 can directly detect the second detection sample in the reusable incubation chamber.

[0138] In some embodiments, if the second detection component is used to detect the second detection sample and the third detection sample simultaneously, for the description of the specific transfer, incubation and detection processes of the third detection sample, please refer to the relevant description of the second detection sample and will not be elaborated here.

[0139] The second optical detection element includes a second light source and a second optical detector, and the second light source and the second optical detector are arranged at a relative interval with respect to the reusable incubation chamber. Specifically, it means that the second light source and the second optical detector are configured on the external bearing frame (such as the support described later) of the reusable incubation chamber in a spatially separated structure, and the two are arranged opposite to each other in the first direction and form an optical path. Specifically, the emission optical axis of the second light source and the receiving optical axis of the second optical detector are coaxially aligned or have a certain angle in three-dimensional space, and the relative interval is not less than the lateral dimension of the incubation chamber, so that the emission light generated by the second light source can pass through the reaction cup in the incubation chamber and be captured by the second optical detector.

[0140] Furthermore, the relative interval setting includes, but is not limited to, mechanical configurations such as horizontal symmetric distribution, vertical staggered distribution or specific inclination distribution. The core feature is that a non-coplanar spatial separation relationship is formed between the light source and the detector, and a precise optical alignment mechanism is used to ensure that the effective transmission path of the detection beam passes through the sample detection area.

[0141] In addition, the reusable incubation chamber and the second light source are relatively movable. The incubation component 503 moves the reusable incubation chamber containing the second detection sample through the emission area of the second light source, so that the emission light emitted by the second light source passes through the reaction cup placed in the reusable incubation chamber and is received by the second optical detector. Thus, the second detection signal available for analysis is detected, where the reusable incubation chamber enters the emission area of the second light source according to a preset rotation period.

[0142] The reusable incubation chamber and the second light source are relatively moved specifically through mechanisms such as the second detection disc or the detection track described above.

[0143] In some embodiments, the incubation component includes a support, the second light source and the second optical detector are both arranged on the support, and the reusable incubation chamber is provided with a first optical window and a second optical window; when the reusable incubation chamber passes through the emission area of the second light source, the emission light emitted by the second light source first enters the reusable incubation chamber through the first optical window, then passes through the reaction cup placed in the reusable incubation chamber, and then passes through the second optical window and is received by the second optical detector, so as to detect the second detection signal or the third detection signal available for analysis.

[0144] Specifically, please refer to Figure 6 , Figure 6 FIG. is a schematic diagram of a test process of a reusable incubation chamber provided by an embodiment of the present application, which includes a support 5031, a second light source 5032, a second optical detector 5033, a reusable incubation chamber 5034, a first optical window 5035, and a second optical window 5036.

[0145] As Figure 6 shown, when the reusable incubation chamber 5034 passes through the emission area of the second light source 5032, the emission light emitted by the second light source 5032 enters the reusable incubation chamber 5034 through the first optical window 5035, then passes through the reaction cup placed in the reusable incubation chamber 5034, and finally passes through the second optical window 5036 and is received by the second optical detector 5033. In order to measure the second detection signal or the third detection signal available for analysis.

[0146] Further, the structure shown in Figure 6 may also exist in the first detection component, the second detection component, and the third detection component. The first detection component, the second detection component, and the third detection component can also realize their respective sample detections through the same structure shown in Figure 6 shown.

[0147] Optionally, a second optical detector 5033 is respectively configured on the wall of each reusable incubation chamber. Each time the reusable incubation chamber or the second detection position passes through the emission area of the light source, the optical detector configured on the wall of the reusable incubation chamber or the detection position can receive the emission light emitted by the light source, so as to obtain an available analysis detection signal.

[0148] Optionally, on the premise that an optical detector is respectively configured on the wall of each reusable incubation chamber. In the incubation component, only the reusable incubation chamber and the detection position need to be provided with structures similar to the first optical window 5035 and the second optical window 5036 for corresponding optical tests.

[0149] For the samples in the reaction cups in the incubation chamber, the incubation component 503 only needs to perform incubation operations on them and does not need to perform optical tests. Therefore, there is no need to set up structures similar to the first optical window 5035 and the second optical window 5036 on the incubation chamber.

[0150] It can be seen that in the embodiment of the present application, by arranging the second detection component inside the incubation component, for the samples that need to be detected by the second detection component, it is beneficial to simplify the structure of the coagulation analyzer and reduce the volume.

[0151] In some possible embodiments, the first light source or the second light source is a multi-wavelength coupled light source; the emitted light emitted by the multi-wavelength coupled light source is split after passing through the reaction cup, and the optical signals of each optical path after splitting are received by at least one optical detector, and the optical signals of at least part of the optical paths are detection signals available for analysis.

[0152] Specifically, in this embodiment, the first light source, the second light source or the third light source is a multi-wavelength coupled light source. The optical detectors specifically include a first optical detector, a second optical detector, and a third optical detector. The detection signals specifically include a first detection signal, a second detection signal, and a third detection signal.

[0153] When the light source (such as the first light source, the second light source, and the third light source) is a multi-wavelength coupled light source. During the detection process, after the emitted light is generated from the light source and passes through the reaction cup, it is split by a grating or an optical fiber + filter, and is decoupled into multiple single-wavelength lights, and each path will be collected by an optical detector (including the first optical detector, the second optical detector, or the third optical detector).

[0154] The processor then selects the detection signals of the corresponding paths for analysis according to the requirements of the detection methodology corresponding to the currently detected sample, so as to eliminate the channel difference of the optical channels.

[0155] Exemplarily, the second detection component is used to detect samples of immunoturbidimetry and colorimetry. Immunoturbidimetry requires a light source with a wavelength of 565 nm, and colorimetry requires a light source with a wavelength of 405 nm.

[0156] The multi-wavelength coupled second light source here can emit coupled light including at least wavelengths of 405 nm and 565 nm.

[0157] The transfer component places the detection samples corresponding to immunoturbidimetry and the detection samples corresponding to colorimetry on two second detection positions, so that in a single detection, the second light source can simultaneously or separately emit emitted light including wavelengths of 565 nm and 405 nm to irradiate the detection samples corresponding to immunoturbidimetry and the detection samples corresponding to colorimetry.

[0158] After the emitted light is generated from the light source and passes through the reaction cuvette, it is split by a grating or an optical fiber + filter, and decoupled into single-wavelength light with wavelengths of 565 nm and 405 nm.

[0159] For the test sample corresponding to the immunoturbidimetry assay, the processor selects the detection signal of the 565 nm wavelength path to analyze the corresponding test result. For the test sample corresponding to the colorimetric assay, the processor selects the detection signal of the 405 nm wavelength path to analyze the corresponding test result.

[0160] In addition, it should be noted that each optical detector is used to receive light of a corresponding wavelength. Therefore, in the case where the light source is a multi-wavelength coupled light source, one light source corresponds to multiple optical detectors, or one light source corresponds to an array-type optical detector, and multiple optical detectors or an array-type optical detector are used to receive the optical data corresponding to all wavelength light sources in the multi-wavelength coupled light source.

[0161] Each light source and the corresponding optical detector are installed at the first irradiation angle or the second irradiation angle, where the first irradiation angle corresponds to the transmission method and the second irradiation angle corresponds to the scattering method.

[0162] The installation angle of the light source and the corresponding optical detector is determined based on the corresponding detection methodology.

[0163] It should be noted that immunocolorimetry and turbidimetry are more suitable for the transmission method, while the coagulation method can use either the transmission method or the scattering method.

[0164] Therefore, if the test sample to be detected by the light source and the corresponding optical detector corresponds to immunocolorimetry or turbidimetry, it is installed at the first irradiation angle to achieve the best detection effect for immunocolorimetry and turbidimetry; if the test sample to be detected by the light source and the corresponding optical detector corresponds to the coagulation method, it is installed at the first irradiation angle or the second irradiation angle, and the specific irradiation angle to be selected can be determined after obtaining the test signal through actual detection tests to achieve the best detection effect for the coagulation method.

[0165] It can be seen that in the embodiment of the present application, by using a multi-wavelength coupled light source to detect the sample, only one light source needs to be set in the detection component to achieve the detection corresponding to multiple detection methodologies, saving the optical components required for the coagulation analyzer and simplifying the overall architecture of the coagulation analyzer.

[0166] It can be seen that in the embodiment of the present application, by using a single-wavelength light source with a lower cost to detect the sample, the production cost of the coagulation analyzer is saved.

[0167] Specifically, in this embodiment, the first light source, the second light source, or the third light source is a single-wavelength light source. The optical detector specifically includes a first optical detector, a second optical detector, and a third optical detector, and the detection signals specifically include a first detection signal, a second detection signal, and a third detection signal.

[0168] It should be noted that in various commonly used detection methodologies, the colorimetric method generally requires a light source with a wavelength of 405 nm, the immunoturbidimetry method generally requires a light source with a wavelength of 575 nm or 800 nm, and the coagulation method generally requires a light source with a wavelength of 405 nm or 660 nm or 800 nm.

[0169] Therefore, in the embodiments of the present application, since the first detection component and the third detection component only need to detect the samples corresponding to the first detection methodology, at least one single-wavelength light source that supports any one of the wavelengths required by the corresponding detection methodology can be included in the first detection component and the third detection component at least.

[0170] For the second detection component, there is a case where the samples corresponding to the second detection methodology and the third detection methodology need to be detected. If the light source wavelengths required by the second detection methodology and the third detection methodology are different, at least two single-wavelength second light sources that support different wavelengths are included in the second detection component.

[0171] Exemplarily, the second detection component includes a single-wavelength second light source that supports a wavelength of 405 nm corresponding to the second detection methodology, and a single-wavelength second light source that supports a wavelength of 575 nm corresponding to the third detection methodology. The single-wavelength second light source that supports a wavelength of 405 nm is used to detect the second detection sample corresponding to the second detection methodology; the single-wavelength second light source that supports a wavelength of 575 nm is used to detect the third detection sample corresponding to the third detection methodology.

[0172] When the second detection sample corresponding to the second detection methodology enters the detection range of these two second light sources, the processor then acquires the detection signal of the 405-nm wavelength path as the second detection signal of the second detection sample.

[0173] Relatively, if the third detection sample of the third detection methodology is being detected, the processor then acquires the detection signal of the 575-nm wavelength path as the second detection signal of the third detection sample.

[0174] It can be seen that in the embodiments of the present application, by using a single-wavelength light source with a lower cost to detect the samples, the production cost of the coagulation analyzer is saved.

[0175] The above embodiments describe a coagulation analyzer in which a second detection component is disposed inside an incubation component. Based on this, on the premise that the second detection component includes a second detection disk or a second detection track, the embodiments of the present application further provide a structure of a coagulation analyzer.

[0176] Please refer to Figure 7 , Figure 7 which is a schematic structural diagram of another coagulation analyzer provided by the embodiments of the present application. The coagulation analyzer 700 includes: a processor 701, a reagent adding component 702, an incubation component 703, a first detection component 704, a transfer component 705, and a second detection component.

[0177] Here, only the connection relationship between the processor 701 and the first detection component 704 and the incubation component 703 is shown. In fact, the processor 701 is also connected to the reagent adding component 702, the incubation component 703, and the transfer component 705 to control Figure 7 the reagent adding component 702, the incubation component 703, and the transfer component 705 shown in

[0178] For a detailed description of the processor 701, the reagent adding component 702, and the transfer component 705, please refer to Figure 1 the relevant content, which will not be elaborated here.

[0179] The second detection component is disposed inside the incubation component 703. The second detection component includes a plurality of second detection positions and a second optical detection element 7052. Among them, the plurality of second detection positions are multiplexed with the incubation chambers, and the incubation chambers multiplexed with the second detection positions are called multiplexed incubation chambers 7051. The multiplexed incubation chambers 7051 and the second optical detection element 7052 are disposed on the incubation component 703.

[0180] For the sake of convenience of description, in Figure 7 the example shown, only three multiplexed incubation chambers 7051 are shown in the incubation component 703. There may be more or fewer multiplexed incubation chambers 7051 provided on the incubation component 703. And in Figure 7 the example shown, all the incubation chambers in the incubation component 703 are multiplexed incubation chambers. In actual applications, only some of the incubation chambers may be multiplexed with the second detection positions.

[0181] The incubation component 703 further includes an incubation disk 7053. The incubation disk 7053 is used to drive the multiplexed incubation chambers 7051 to move, so as to move the empty multiplexed incubation chambers 7051 to a position close to the transfer component 705, or move the multiplexed incubation chambers 7051 containing the incubated reaction cups to a position close to the transfer component 705, so that the transfer component 705 can transfer the reaction cups.

[0182] When a second test sample or a third test sample to be detected is placed on the reusable incubation chamber 7051, the incubation tray 7053 can also rotate at a preset rotation speed, so that the reusable incubation chamber 7051 can enter the emission area of the second light source of the second optical detection element 7052 at a preset frequency. When the reusable incubation chamber 7051 passes through the emission area of the second light source, the emitted light from the second light source, after passing through the reaction cup placed in the reusable incubation chamber 7051, is received by the second optical detector of the second optical detection element 7052, thereby detecting a second test signal or a third test signal for analysis.

[0183] In some embodiments, the incubation tray 7053 rotates at a first speed to enable the transfer assembly 705 to place the reaction cup on the reusable incubation chamber 7051 or remove the reaction cup from the reusable incubation chamber 7051; the incubation tray 7053 rotates at a second speed to enable a plurality of reusable incubation chambers 7051 to enter the emission area of the second light source in the second optical detection element 7052 at a preset frequency for detection.

[0184] Specifically, for the case where the incubation tray 7053 rotates at the first speed:

[0185] When the transfer assembly 705 needs to place the reaction cup on the reusable incubation chamber 7051 or transfer the reaction cup from the reusable incubation chamber 7051, the incubation tray 7053 rotates at the first speed. The first speed is set based on the transfer assembly. If the transfer range of the transfer assembly can cover all the reusable incubation chambers 7051.

[0186] Further, when the transfer assembly 705 needs to place the reaction cup on the reusable incubation chamber 7051, the incubation tray 7053 rotates at the first speed to move an empty reusable incubation chamber 7051 close to the transfer assembly 705; or when the transfer assembly 705 needs to remove the reaction cup from the reusable incubation chamber 7051, the incubation tray 7053 rotates at the first speed to move the reusable incubation chamber 7051 where a reaction cup to be removed is located close to the transfer assembly 705. At other times, the incubation tray 7053 can rotate at a constant speed lower than the first speed or remain stationary.

[0187] For the case where the incubation tray 7053 rotates at the second speed:

[0188] The second speed here is determined based on the second detection methodology and the third detection methodology. The incubation tray 7053 rotates at the second speed to enable a plurality of reusable incubation chambers 7051 to enter the emission area of the second light source at a preset frequency. The preset frequency meets the detection frequency requirements of the second detection methodology and the third detection methodology. The first speed and the second speed can be the same or different.

[0189] It should be further noted that during the rotation of the incubation tray 7053 at the second speed, if the detection sample to be detected is placed in the reusable incubation chamber 7051, it can enter the emission area of the second light source at a preset frequency for detection. For the reusable incubation chamber 7051 without the detection sample to be detected, the reagent addition component 702, the transfer component 705, and the incubation component 703 can also perform operations such as reagent addition, transfer, and incubation on the reaction cups in the reusable incubation chamber 7051 without interfering with the detection samples being detected.

[0190] Optionally, the incubation tray 7053 here can also be replaced with an incubation track. For relevant descriptions, please refer to the relevant descriptions of the second detection tray and the second detection track above, and will not be elaborated here.

[0191] From the coagulation analyzer in the above application embodiments, it can be seen that the decoupled design of the detection components based on different detection methodologies reduces the detection design difficulty of the coagulation analyzer, improves the design flexibility, and increases the detection efficiency of some detection items. The detection positions in the first detection component and / or the second detection component and the optical detection element are relatively movable, eliminating the channel difference. Based on different detection frequencies, the unified detection component is decoupled into different first detection components and second detection components, reducing the design difficulty of the coagulation analyzer and improving the detection efficiency. The second detection component is arranged in the incubation component, further simplifying the structure of the coagulation analyzer. The use of a multi-wavelength coupled light source further simplifies the overall architecture of the coagulation analyzer. The use of a single-wavelength light source saves the production cost of the coagulation analyzer and improves the processing efficiency of coagulation analysis.

[0192] It should be understood that in the description of this application, unless otherwise specified, " / " indicates that the objects associated before and after are in an "or" relationship. For example, A / B can represent A or B; where A and B can be singular or plural. Also, in the description of this application, unless otherwise specified, "a plurality of" means two or more than two. "At least one (item)" or its similar expressions refer to any combination of these items, including any combination of a single item or plural items. For example, at least one (item) of a, b, or c can represent: a, b, c, a - b, a - c, b - c, or a - b - c, where a, b, and c can be single or multiple. Additionally, for the convenience of clearly describing the technical solutions of the embodiments of this application, in the embodiments of this application, terms such as "first" and "second" are used to distinguish the same items or similar items with basically the same functions and roles. Those skilled in the art can understand that the terms "first", "second", etc. do not limit the quantity and execution order, and the terms "first", "second", etc. do not necessarily mean different. At the same time, in the embodiments of this application, words such as "exemplary" or "for example" are used to indicate examples, illustrations, or explanations. Any embodiment or design solution described as "exemplary" or "for example" in the embodiments of this application should not be construed as being more preferred or having more advantages than other embodiments or design solutions. Rather, the use of words such as "exemplary" or "for example" is intended to present relevant concepts in a specific manner for easy understanding.

[0193] As described above, it is only the specific implementation manner of the embodiments of this application, but the protection scope of the embodiments of this application is not limited thereto. Any change or replacement within the technical scope disclosed in the embodiments of this application should be covered by the protection scope of the embodiments of this application. Therefore, the protection scope of the embodiments of this application should be subject to the protection scope of the claims.

[0194] The device embodiments described above are merely illustrative. The units and modules described as separate components may or may not be physically separated. Additionally, some or all of the units and modules can be selected according to actual needs to achieve the purpose of the solutions of this embodiment. A person of ordinary skill in the art can understand and implement it without creative efforts.

[0195] The above description is only the specific implementation manner of this application. It should be noted that for those of ordinary skill in the art of this technology, without departing from the principle of this application, several improvements and refinements can be made, and these improvements and refinements should also be regarded as within the protection scope of this application.

Claims

1. A coagulation analyzer, characterized in that, It includes a processor, a reagent adding component, an incubation component, a first detection component, a second detection component and a transfer component; The reagent adding component is used to add reagents into a reaction cup containing at least a blood sample; The incubation component includes a number of incubation chambers and heaters provided corresponding to the incubation chambers. The incubation chambers are used to place the reaction cups containing the blood sample and the reagents, and the heaters are used to heat the reaction cups to perform an incubation action; The first detection component includes a number of first detection positions and a first optical detection element. The first detection positions are used to place the reaction cups containing a first detection sample formulated from the blood sample and the reagents. The first optical detection element detects a first detection signal for analysis from the first detection sample based on the detection requirements of a first detection methodology; The second detection component includes a number of second detection positions and a second optical detection element. The second detection positions are used to place the reaction cups containing a second detection sample formulated from the blood sample and the reagents. The second optical detection element detects a second detection signal for analysis from the second detection sample based on the detection requirements of a second detection methodology; The transfer component is used to transfer at least part of the reaction cups placed in the incubation chambers to the first detection position or the second detection position; The processor analyzes the blood sample respectively based on the first detection signal and the second detection signal; Wherein, there is relative movement between the first detection position and the first optical detection element, and / or there is relative movement between the second detection position and the second optical detection element.

2. The coagulation analyzer according to claim 1, wherein It further includes a third detection component. The third detection component includes a number of third detection positions and a third optical detection element. The third detection positions are used to place the reaction cups containing a third detection sample formulated from the blood sample and the reagents. The third optical detection element detects a third detection signal for analysis from the third detection sample based on the detection requirements of a third detection methodology; The transfer component is further used to transfer at least part of the reaction cups placed in the incubation chambers to the third detection position; The processor further analyzes the blood sample based on the third detection signal.

3. The coagulation analyzer according to claim 1, wherein The second detection position is further used to place the reaction cups containing the third detection sample formulated from the blood sample and the reagents. The second optical detection element further detects a third detection signal for analysis from the third detection sample based on the detection requirements of the third detection methodology; The processor further analyzes the blood sample based on the third detection signal.

4. The coagulation analyzer according to any one of claims 1-3, characterized in that, The first optical detection element detects a first detection signal for analysis from the first detection sample at a first detection frequency based on the detection requirements of the first detection methodology; The second optical detection element detects a second detection signal for analysis from the second detection sample at a second detection frequency based on the detection requirements of the second detection methodology; Wherein, the first detection frequency is greater than the second detection frequency.

5. The coagulation analyzer according to claim 1 or 3 or 4, characterized in that, The second detection component is arranged inside the incubation component; the second detection position shares at least part of the incubation chamber, and the second optical detection element includes a second light source and a second optical detector, and the second light source and the second optical detector are arranged at intervals relative to the shared incubation chamber; wherein the shared incubation chamber is only used for detection, or is used for incubation and detection simultaneously; When the shared incubation chamber passes through the emission area of the second light source, the emission light emitted by the second light source, after passing through the reaction cup placed in the shared incubation chamber, is received by the second optical detector, so as to detect a second detection signal or a third detection signal for analysis, wherein the shared incubation chamber enters the emission area of the second light source according to a preset rotation period.

6. The coagulation analyzer according to claim 5, characterized in that, The incubation component includes a support, and both the second light source and the second optical detector are arranged on the support, and the shared incubation chamber is provided with a first optical window and a second optical window; When the shared incubation chamber passes through the emission area of the second light source, the emission light emitted by the second light source first enters the shared incubation chamber through the first optical window, then passes through the reaction cup placed in the shared incubation chamber, and then passes through the second optical window and is received by the second optical detector, so as to detect a second detection signal or a third detection signal for analysis.

7. The coagulation analyzer according to claim 1 or 3 or 4, characterized in that, The first detection component includes a first detection disc or a first detection track, and the first detection position is arranged inside the first detection disc or the first detection track; the first optical detection element includes a first light source and a first optical detector, and the first light source and the first optical detector are arranged at intervals relative to the first detection position; wherein, the first detection position enters the emission area of the first light source according to a preset movement period or rotation period; When the first detection position passes through the emission area of the first light source, the emission light emitted by the first light source, after passing through the reaction cup placed in the first detection position, is received by the first optical detector, so as to detect a first detection signal for analysis.

8. The coagulation analyzer according to claim 1 or 3 or 4, characterized in that, The second detection component includes a second detection disc or a second detection track, and the second detection position is arranged inside the second detection disc or the second detection track; the second optical detection element includes a second light source and a second optical detector, and the second light source and the second optical detector are arranged at intervals relative to the second detection position; wherein, the second detection position enters the emission area of the second light source according to a preset movement period or rotation period; When the second detection position passes through the emission area of the second light source, the emission light emitted by the second light source, after passing through the reaction cup placed in the second detection position, is received by the second optical detector, so as to detect a second detection signal or a third detection signal for analysis.

9. The coagulation analyzer according to claim 5 or 7 or 8, characterized in that, The first light source or the second light source is a multi-wavelength coupled light source; The emitted light from the multi-wavelength coupled light source is split after passing through the reaction cuvette, and the optical signals of each optical path after splitting are received by at least one optical detector, wherein the optical signals of at least part of the optical paths are detection signals available for analysis.

10. The coagulation analyzer according to claim 5 or 7 or 8, characterized in that, The first light source or the second light source is a single-wavelength light source; The emitted light from the single-wavelength light source is received by the optical detector after passing through the reaction cuvette, so as to detect the detection signal available for analysis.

Images