Plasma exchange technology simulation training teaching device

Abstract

The invention discloses a plasma exchange technology simulation training teaching device which comprises a blood driving module, a replacement liquid storage tank, a simulation blood vessel, a first liquid storage tank, a second liquid storage tank, a plasma separator, a plasma component separator and a waste liquid storage tank. The blood driving module is used for driving the simulated blood conveyed in the first liquid storage tank to the plasma separator, the plasma separator is used for separating the conveyed simulated blood into plasma components and cell components, and the plasma component separator is used for separating the conveyed plasma into target cells and waste liquid; the displacement liquid storage tank is used for directly conveying displacement liquid to the second liquid storage tank; the side wall of the simulated blood vessel is provided with a visual flow velocity identification assembly; the blood driving module is connected with the first liquid storage tank and is used for driving the blood in the first liquid storage tank into the simulated blood vessel; and the displacement liquid storage tank is communicated with the second liquid storage tank. The plasma exchange technology simulation training teaching device can meet the training requirements of trainees on blood exchange.

Description

Technical Field

[0001] The present invention specifically relates to a simulation training teaching device for plasma exchange technology. Background Art

[0002] The simulation training teaching equipment for plasma exchange technology is a training tool for simulating the plasma exchange process, aiming to help medical staff familiarize themselves with and master the operation process and precautions of plasma exchange technology, so as to improve the safety and effectiveness in actual operation. Plasma exchange technology plays an important role in the treatment of various diseases, such as myasthenia gravis, multiple organ failure, rare diseases, etc. However, the indications, contraindications and treatment plans for different diseases vary, which requires the training content to be comprehensive and accurate, and at the same time be able to be personalized according to the specific situation of the patient. However, this technology is complex. Plasma exchange technology involves multiple operation steps and equipment use, such as double-filtration plasmapheresis (DFPP), etc. These technologies require operators to have solid professional knowledge and skills, including the proficient operation of equipment such as plasma separators and plasma component separators, as well as the ability to prevent and handle possible complications during the treatment process. At the same time, serious complications such as hypotension, hypovolemia, infection, and vascular embolism may occur during plasma exchange, requiring operators to have good clinical thinking and judgment abilities, coordination and organization abilities, and emergency handling abilities. Therefore, the difficulty in training plasma exchange technology lies in its complexity, professionalism, and high requirements for the comprehensive quality of operators. To overcome these difficulties, a systematic training plan, rich practical experience, and continuous educational support are needed. Currently, there is no teaching equipment specifically for this project on the market. Summary of the Invention

[0003] Aiming at the deficiencies of the existing technology, the technical problem to be solved by the present invention is to provide a simulation training teaching device for plasma exchange technology to meet the training needs of trainees for blood exchange.

[0004] To achieve the above object, the present invention is implemented by the following technical solutions: A simulation training teaching device for plasma exchange technology, comprising:

[0005] Comprising a blood driving module, a replacement fluid storage tank, and a first liquid storage tank, a second liquid storage tank, a plasma separator, a plasma component separator, and a waste liquid storage tank connected through an elastically compressible transparent simulated blood vessel;

[0006] The blood driving module is used to drive the simulated blood in the first liquid storage tank to the plasma separator, and the driving speed of the blood driving module is adjustable. The plasma separator is used to separate the transported simulated blood into plasma components and cell components. The plasma component separator is used to separate the transported plasma into target cells and waste liquid, and transport the target cells back to the second liquid storage tank and the waste liquid to the waste liquid storage tank. The replacement liquid storage tank is used to directly transport the replacement liquid to the second liquid storage tank; the side wall of the simulated blood vessel is provided with a visual flow rate marking component; the blood driving module is connected to the first liquid storage tank and is used to drive the blood in the first liquid storage tank into the simulated blood vessel, and the driving speed of the blood driving module is adjustable;

[0007] The replacement liquid storage tank is communicated with the second liquid storage tank through an independent pipeline.

[0008] Further, the visual flow rate marking component includes an ultraviolet light-excitable fluorescent coating coated on the inner wall of the simulated blood vessel and annular scale markings arranged at intervals along the outer surface of the simulated blood vessel.

[0009] Further, the blood driving module includes a piston plate slidably arranged in the tank body and a linear motion driving source, and the linear motion driving source is connected to the piston plate and is used to drive the piston plate to move up and down.

[0010] Further, the plasma separator includes a housing, a filter membrane assembly and a centrifugal rotation driving component. The filter membrane assembly is rotatably arranged in the housing, and divides the inner cavity of the housing into an inner separation cavity and a replacement cavity. The first liquid storage tank is communicated with the separation cavity, the replacement cavity is communicated with the second liquid storage tank, and the centrifugal rotation driving component is connected to the filter membrane assembly and is used to drive the filter membrane assembly to rotate at a high speed.

[0011] Further, the centrifugal rotation driving component includes a first transmission gear, a rotation driving source and a second transmission gear. The first transmission gear is sleeved and fixed outside the filter membrane assembly. The second transmission gear is rotatably arranged in the housing and meshes with the first transmission gear. The rotation driving source is arranged outside the housing, and the rotation driving source is connected to the second transmission gear and is used to drive the second transmission gear to rotate.

[0012] Further, the linear motion driving source includes a belt drive assembly, a third transmission gear, a fourth transmission gear, and a screw rod. The screw rod vertically inserts into the first liquid storage tank from the top of the first liquid storage tank, is rotatably connected to the piston plate, and is slidably connected to the top of the first liquid storage tank. The third transmission gear is sleeved on the screw rod, is threadedly connected to the screw rod, and is rotatably connected to the top of the first liquid storage tank. The fourth transmission gear can rotate the top of the first liquid storage tank and meshes with the third transmission gear. The rotary driving source drives the fourth transmission gear to rotate through the belt drive assembly.

[0013] Further, it further includes a flow rate control module, which is connected to the simulated blood vessel and is used to control the blood flow rate in the simulated blood vessel.

[0014] Further, the flow rate control module includes a rotary power source, a three-stage speed-changing gear set, and an eccentric cam. The three-stage speed-changing gear includes a main driving gear, an intermediate gear, and an output gear, and the transmission ratios between the main driving gear, the intermediate gear, and the output gear gradually increase. The eccentric cam is fixedly installed at the end of the output gear shaft, and the outer edge of the cam is always in contact with the outer wall of the simulated blood vessel. The rotary power source is connected to the main driving gear and is used to drive the main driving gear to rotate.

[0015] Advantages of the present invention:

[0016] When the above plasma exchange technology simulation training teaching device is in use, the blood driving module pumps the simulated blood in the first liquid storage tank into the plasma separator. The plasma separator separates the transported plasma into plasma components and cell components. The cell components enter the second liquid storage tank through the simulated blood vessel. The plasma components enter the plasma component separator and are separated into target cells and waste liquid. The target cells flow into the second liquid storage tank, and the waste liquid flows into the waste liquid storage tank. The replacement liquid flows into the second liquid storage tank through an independent pipeline. During the training process, the blood flow rate can be observed through the visual flow rate marking component, and the driving speed of the blood driving module can be adjusted through the blood driving module as needed. Thus, it is convenient for students to carry out simulation training. Description of the Drawings

[0017] In order to more clearly illustrate the specific embodiments of the present invention, the drawings required for use in the specific embodiments will be briefly introduced below. In all the drawings, the elements or parts do not necessarily draw according to the actual ratio.

[0018] Figure 1 Schematic diagram of a plasma exchange technology simulation training teaching device provided by an embodiment of the present invention;

[0019] Figure 2 For Figure 1Schematic diagram of the flow rate control module in the plasma exchange technology simulation training teaching device shown;

[0020] Figure 3 is Figure 1 Assembly schematic diagram of the plasma separator and the blood drive module in the plasma exchange technology simulation training teaching device shown;

[0021] Reference numerals:

[0022] 100, first liquid storage tank; 200, second liquid storage tank; 300, plasma separator; 310, outer shell; 320, filter membrane assembly; 330, centrifugal rotation drive assembly; 331, rotation drive source; 332, first transmission gear; 333, second transmission gear; 400, plasma component separator; 500, waste liquid storage tank; 600, replacement liquid storage tank; 700, blood drive module; 710, piston plate; 720, linear motion drive source; 721, belt drive assembly; 722, third transmission gear; 723, fourth transmission gear; 724, screw; 800, flow rate control module; 810, rotational power source; 820, three-stage speed reduction gear set; 830, eccentric cam; 900, centrifugal feedback module; 910, dial; 920, elastic member; 930, slider. Detailed implementation manners

[0023] To make the above objects, features and advantages of the present invention more obvious and understandable, the following will describe the detailed implementation manners of the present invention in conjunction with the accompanying drawings. Many specific details are set forth in the following description in order to fully understand the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the connotation of the present invention. Therefore, the present invention is not limited by the specific implementations disclosed below.

[0024] Please refer to Figures 1 to 3 , the present invention provides a plasma exchange technology simulation training teaching device, including a blood drive module 700, a replacement liquid storage tank 600, and a first liquid storage tank 100, a second liquid storage tank 200, a plasma separator 300, a plasma component separator 400, and a waste liquid storage tank 500 connected through an elastically compressible transparent simulated blood vessel. In specific implementation, the simulated blood vessel can be made of silica gel material, and its elastic modulus is 0.5 - 1.2 MPa. The simulated blood can be composed of the following components: a glycerol aqueous solution with a mass fraction of 60 - 70%, 5 - 8% of sodium carboxymethylcellulose, and 0.1 - 0.3% of iron oxide red dye, with a viscosity of 3.5 - 4.5 mPa·s (25°C) and a density of 1.05 - 1.10 g / cm 3 , and it can contain fluorescent tracer particles therein.

[0025] The blood driving module 700 is used to drive the simulated blood in the first liquid storage tank 100 to the plasma separator 300, and the driving speed of the blood driving module 700 is adjustable. The plasma separator 300 is used to separate the incoming simulated blood into plasma components and cell components. The plasma component separator 400 is used to separate the incoming plasma into target cells and waste liquid, and convey the target cells back to the second liquid storage tank 200 and the waste liquid to the waste liquid storage tank 500. The replacement liquid storage tank 600 is used to directly convey the replacement liquid to the second liquid storage tank 200. The side wall of the simulated blood vessel is provided with a visual flow rate marking component; the blood driving module 700 is connected to the first liquid storage tank 100 and is used to drive the blood in the first liquid storage tank 100 into the simulated blood vessel, and the driving speed of the blood driving module 700 is adjustable. The replacement liquid storage tank 600 is communicated with the second liquid storage tank 200 through an independent pipeline.

[0026] During use, the blood driving module 700 pumps the simulated blood in the first liquid storage tank 100 into the plasma separator 300. The plasma separator 300 separates the incoming plasma into plasma components and cell components. The cell components enter the second liquid storage tank 200 through the simulated blood vessel. The plasma components enter the plasma component separator 400 and are separated into target cells and waste liquid. The target cells flow into the second liquid storage tank 200, and the waste liquid flows into the waste liquid storage tank 500. The replacement liquid flows into the second liquid storage tank 200 through an independent pipeline. During the training process, the flow rate of the blood can be observed through the visual flow rate marking component, and the driving speed of the blood driving module 700 can be adjusted through the blood driving module 700 as needed. Thus, it is convenient for students to carry out simulation training.

[0027] In this embodiment, the visual flow rate marking component includes a UV light-excitable fluorescent coating coated on the inner wall of the simulated blood vessel and annular scale markings arranged at intervals along the outer surface of the simulated blood vessel.

[0028] In specific implementation, the fluorescent layer can be composed of a UV-curable fluorescent nano-coating (excitation wavelength 365 nm), the coating thickness is 50 μm, and a spiral flow channel marking is formed along the axial direction of the blood vessel. The annular scale markings can adopt annular laser etching scales (accuracy ±0.1 mm), the spacing is 5 mm ±0.5 mm, and the scale depth is 0.2 mm and filled with a reflective material.

[0029] Under the irradiation of ultraviolet light, the fluorescent layer shows the laminar boundary layer morphology of the fluid. The operator judges the flow rate distribution (laminar flow / turbulent flow) by comparing the distortion degree of the spiral marking, and calculates the average flow rate through the time of the fluorescent particles passing between adjacent scales (t = ΔL / ΔT).

[0030] By adopting this method, the flow rate of the blood can be intuitively reflected, which is convenient for a deeper understanding and operation of blood replacement.

[0031] In this embodiment, the blood driving module 700 includes a piston plate 710 slidably disposed in the tank and a linear motion driving source 720. The linear motion driving source 720 is connected to the piston plate 710 and is used to drive the piston plate 710 to move up and down to squeeze out the blood. In specific implementation, a blood replenishing device may also be provided on the first liquid storage tank 100 to replenish the first liquid storage tank 100 with blood at any time.

[0032] In this embodiment, the plasma separator 300 includes a housing 310, a filter membrane assembly 320, and a centrifugal rotation driving assembly 330. The filter membrane assembly 320 is rotatably disposed in the housing 310, dividing the inner cavity of the housing 310 into an inner separation chamber and a replacement chamber. The first liquid storage tank 100 is communicated with the separation chamber, and the replacement chamber is communicated with the second liquid storage tank 200. The centrifugal rotation driving assembly 330 is connected to the filter membrane assembly 320 and is used to drive the filter membrane assembly 320 to rotate at a high speed.

[0033] Specifically, the centrifugal rotation driving assembly 330 includes a first transmission gear 332, a rotation driving source 331, and a second transmission gear 333. The first transmission gear 332 is sleeved and fixed outside the filter membrane assembly 320. The second transmission gear 333 is rotatably disposed in the housing 310 and meshes with the first transmission gear 332. The rotation driving source 331 is disposed outside the housing 310, and the rotation driving source 331 is connected to the second transmission gear 333 and is used to drive the second transmission gear 333 to rotate.

[0034] During use, when the rotation driving source 331 is started, the filter membrane assembly 320 can be driven to rotate through the first transmission gear 332 and the second transmission gear 333 to perform centrifugal separation on the blood.

[0035] In this embodiment, the linear motion driving source 720 includes a belt transmission assembly 721, a third transmission gear 722, a fourth transmission gear 723, and a screw 724. The screw 724 is vertically inserted into the first liquid storage tank 100 from the top of the first liquid storage tank 100 and is rotatably connected to the piston plate 710, and is slidably connected to the top of the first liquid storage tank 100. The third transmission gear 722 is sleeved on the screw 724, is threadedly connected to the screw 724, and is rotatably connected to the top of the first liquid storage tank 100. The fourth transmission gear 723 is rotatably disposed on the top of the first liquid storage tank 100 and meshes with the third transmission gear 722. The rotation driving source 331 drives the fourth transmission gear 723 to rotate through the belt transmission assembly 721.

[0036] When the rotary drive source 331 is started, the screw 724 can be driven to rotate through the belt drive assembly 721, the third transmission gear 722, and the fourth transmission gear 723, thereby achieving the purpose of pushing the piston plate 710 to move. Of course, in other embodiments, the linear motion drive source 720 can also be in other forms, such as directly driving the piston plate 710 to move through a telescopic rod.

[0037] At the same time, by adopting this method, the blood pumping speed and the centrifugal speed can be matched, which can improve the replacement effect.

[0038] As a more effective implementation, the device also includes a centrifugal feedback module 900, which includes a dial 910, an elastic member 920 and a slider 930. The dial 910 is sleeved and fixed on the power output shaft of the rotating drive source 331. A plurality of concentric circles marked with numbers are arranged at intervals on the dial 910. The dial 910 is provided with a slide groove extending radially from the center of the circle. The sliding block can be slidably engaged in the slide groove. The elastic member 920 is arranged along the slide groove, and the two ends are respectively connected to the center of the slider 930 and the dial 910.

[0039] When in use, when the dial 910 rotates at high speed along with the power output shaft of the rotating drive source 331, under the action of centrifugal force, the slider 930 moves outward along the slide groove. The operator only needs to observe the scale position corresponding to the slider 930 to intuitively know the speed of rotation of the filter membrane assembly 320 at this time.

[0040] As another preferred implementation, the device further includes a flow rate control module 800 connected to the simulated blood vessel for controlling the blood flow rate in the simulated blood vessel.

[0041] Specifically, the flow rate control module 800 includes a rotational power source 810, a three-stage speed-changing gear set 820 and an eccentric cam 830. The three-stage speed-changing gear set 820 includes a main drive gear, an intermediate gear and an output gear, and the transmission ratio among the main drive gear, the intermediate gear and the output gear gradually decreases. The eccentric cam 830 is fixedly installed at the shaft end of the output gear, and the outer edge of the cam is always in contact with the outer wall of the simulated blood vessel. The rotational power source 810 is connected to the main drive gear for driving the main drive gear to rotate.

[0042] During use, when the rotary power source 810 is started, the eccentric cam 830 is driven to rotate, and the outer edge of the eccentric cam 830 squeezes the simulated blood vessel, which can change the cross-sectional area of ​​the simulated blood vessel, thereby changing the blood flow rate.

[0043] The training steps using the above device are:

[0044] 1. Pour simulated blood into the first liquid storage tank 100 and start the rotary drive source 331;

[0045] 2. Blood enters the plasma separator 300 through the simulated blood vessels. Observe the fluorescence flow rate marker and adjust the rotation speed of the rotation drive source 331.

[0046] 3. Open the replacement fluid storage tank 600, adjust the replenishment rate of the replacement fluid, and synchronously adjust the cam compression amount to maintain stable blood pressure, then the replacement simulation can be carried out.

[0047] 4. By artificially creating a pipeline embolism, the trainee implements emergency treatment.

[0048] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some or all of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention, and they should all be covered by the scope of the claims and the description of the present invention.

Claims

1. A plasma exchange technology simulation training teaching device, characterized in that It includes a blood driving module, a replacement fluid storage tank, a first liquid storage tank, a second liquid storage tank, a plasma separator, a plasma component separator, and a waste liquid storage tank connected through an elastically compressible transparent simulated blood vessel; The blood driving module is used to drive the simulated blood in the first liquid storage tank to the plasma separator, and the driving speed of the blood driving module is adjustable. The plasma separator is used to separate the incoming simulated blood into plasma components and cell components. The plasma component separator is used to separate the incoming plasma into target cells and waste liquid, and transport the target cells back to the second liquid storage tank and the waste liquid to the waste liquid storage tank. The replacement fluid storage tank is used to directly transport the replacement fluid to the second liquid storage tank; A visual flow rate marking component is provided on the side wall of the simulated blood vessel; The blood driving module is connected to the first liquid storage tank for driving the blood in the first liquid storage tank into the simulated blood vessel, and the driving speed of the blood driving module is adjustable; The replacement fluid storage tank is communicated with the second liquid storage tank through an independent pipeline.

2. The plasma exchange technology simulation training teaching device according to claim 1, characterized in that, The visual flow rate marking component includes an ultraviolet light-excitable fluorescent coating coated on the inner wall of the simulated blood vessel and annular scale markings arranged at intervals along the outer surface of the simulated blood vessel.

3. The plasma exchange technology simulation training teaching device according to claim 1, wherein, The blood driving module includes a piston plate slidably arranged in the tank body and a linear motion driving source connected to the piston plate for driving the piston plate to move up and down.

4. The plasma exchange technology simulation training teaching device according to claim 3, wherein, The plasma separator includes a housing, a filter membrane assembly, and a centrifugal rotation driving component. The filter membrane assembly is rotatably arranged in the housing, dividing the inner cavity of the housing into an inner separation cavity and a replacement cavity. The first liquid storage tank is communicated with the separation cavity, the replacement cavity is communicated with the second liquid storage tank, and the centrifugal rotation driving component is connected to the filter membrane assembly for driving the filter membrane assembly to rotate at a high speed.

5. The plasma exchange technology simulation training teaching device according to claim 4, characterized in that, The centrifugal rotation driving component includes a first transmission gear, a rotation driving source, and a second transmission gear. The first transmission gear is sleeved and fixed outside the filter membrane assembly. The second transmission gear is rotatably arranged in the housing and meshes with the first transmission gear. The rotation driving source is arranged outside the housing and is connected to the second transmission gear for driving the second transmission gear to rotate.

6. The plasma exchange technology simulation training teaching device according to claim 5, characterized in that, The linear motion driving source includes a belt transmission component, a third transmission gear, a fourth transmission gear, and a screw rod. The screw rod vertically inserts into the first liquid storage tank from the top of the first liquid storage tank and is rotatably connected to the piston plate, and is slidably connected to the top of the first liquid storage tank. The third transmission gear is sleeved on the screw rod, is threadedly connected to the screw rod, and is rotatably connected to the top of the first liquid storage tank. The fourth transmission gear is rotatably arranged at the top of the first liquid storage tank and meshes with the third transmission gear. The rotation driving source drives the fourth transmission gear to rotate through the belt transmission component.

7. The plasma exchange technology simulation training teaching device according to claim 1, characterized in that, It further includes a flow rate control module connected to the simulated blood vessel for controlling the blood flow rate in the simulated blood vessel.

8. The plasma exchange technology simulation training teaching device according to claim 7, characterized in that, The flow rate control module includes a rotary power source, a three-stage speed-changing gear set, and an eccentric cam. The three-stage speed-changing gear set includes a main driving gear, an intermediate gear, and an output gear, and the transmission ratios between the main driving gear, the intermediate gear, and the output gear gradually increase. The eccentric cam is fixedly installed at the shaft end of the output gear, and the outer edge of the cam is always in contact with the outer wall of the simulated blood vessel. The rotary power source is connected to the main driving gear and is used to drive the main driving gear to rotate.

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